Ligand: 5WE

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 6X3OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 6X3NA Q06187 392 659 659.0 ULV:701,5WE:702 Type1,Allosteric Inactive DFGin 4.8348 13.7977 BLBplus -128.18, -176.06 44.41, 34.78 -60.88, 111.95 32.8, 95.06 63.47, 33.77 out-out out 11.6687 Saltbr-out 11.8984 HRD-in -66.13, -43.52 63.4, 23.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -10.53 APE9-dihe-in -64.61, 137.44 APE8-dihe-in -75.97, 67.43 APE8-rot-na 33.99 APE67-dihe-in -69.55, -8.99 -53.26, -46.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.6731 APE9-dist-in 7.8964 None None None XRAY 1.95 0.215 0.242 A 271.0 254.0 14 29 15 14 [[402, 653]] 1.0 6x3n TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBOA Q06187 392 659 659.0 5WH:1001,5WE:1002 Type1.5_Back,Allosteric Inactive DFGin 4.9335 14.0794 BLBplus -127.34, -179.25 51.08, 30.68 -63.41, 107.22 34.59, 90.39 57.28, 50.21 out-out out 11.9542 Saltbr-out 14.2301 HRD-in -61.25, -46.68 71.35, -12.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.03, 2.31 APE9-dihe-in -65.0, 140.35 APE8-dihe-in -74.92, 62.27 APE8-rot-na 32.17 APE67-dihe-in -71.92, -9.91 -51.18, -45.3 APE12-dist-na 999.0 APE11-dist-na 17.4062 APE10-dist-na 13.1956 APE9-dist-out 8.1123 None None None XRAY 1.894 0.212 0.236 A 271.0 255.0 13 29 16 13 [[402, 653]] 1.0 5fbo TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6X3OA Q06187 395 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2723 14.2227 BLBplus -137.77, 172.12 61.73, 21.35 -60.85, 127.83 37.95, 92.24 73.87, -6.38 out-out out 15.17 Saltbr-out 16.0811 HRD-in -75.67, -53.5 81.79, -14.06 out-out-out SNCooo out-out ActLoopNT-out 8.4586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.73, 7.42 APE9-dihe-in -70.0, 142.33 APE8-dihe-in -75.39, 64.77 APE8-rot-na 34.47 APE67-dihe-in -69.38, -11.52 -56.58, -43.22 APE12-dist-na 16.806 APE11-dist-na 18.6039 APE10-dist-na 13.6409 APE9-dist-out 8.5906 None None None XRAY 1.9 0.181 0.213 A 271.0 265.0 0 29 29 0 [[402, 653]] 1.0 6x3o TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6X3OB Q06187 393 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2875 14.0893 BLBplus -138.35, 171.76 61.86, 21.21 -60.49, 128.12 38.08, 92.33 72.6, -5.67 out-out out 15.3768 Saltbr-out 16.6794 HRD-in -75.8, -53.34 80.45, -11.96 out-out-out SNCooo out-out ActLoopNT-out 8.3968 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.41, 10.63 APE9-dihe-in -69.48, 144.31 APE8-dihe-in -76.78, 65.24 APE8-rot-na 34.23 APE67-dihe-in -70.15, -10.73 -56.21, -43.96 APE12-dist-na 16.68 APE11-dist-na 18.4631 APE10-dist-na 13.5744 APE9-dist-out 8.483 None None None XRAY 1.9 0.181 0.213 B 271.0 267.0 0 29 29 0 [[402, 653]] 1.0 6x3o TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK

Ligand: 5WE

Total number of chains: 6
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 100.0% 6X3OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 6X3NA Q06187 392 659 659.0 ULV:701,5WE:702 Type1,Allosteric Inactive DFGin 4.8348 13.7977 BLBplus -128.18, -176.06 44.41, 34.78 -60.88, 111.95 32.8, 95.06 63.47, 33.77 out-out out 11.6687 Saltbr-out 11.8984 HRD-in -66.13, -43.52 63.4, 23.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -10.53 APE9-dihe-in -64.61, 137.44 APE8-dihe-in -75.97, 67.43 APE8-rot-na 33.99 APE67-dihe-in -69.55, -8.99 -53.26, -46.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.6731 APE9-dist-in 7.8964 None None None XRAY 1.95 0.215 0.242 A 271.0 254.0 14 29 15 14 [[402, 653]] 1.0 6x3n Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBOA Q06187 392 659 659.0 5WH:1001,5WE:1002 Type1.5_Back,Allosteric Inactive DFGin 4.9335 14.0794 BLBplus -127.34, -179.25 51.08, 30.68 -63.41, 107.22 34.59, 90.39 57.28, 50.21 out-out out 11.9542 Saltbr-out 14.2301 HRD-in -61.25, -46.68 71.35, -12.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.03, 2.31 APE9-dihe-in -65.0, 140.35 APE8-dihe-in -74.92, 62.27 APE8-rot-na 32.17 APE67-dihe-in -71.92, -9.91 -51.18, -45.3 APE12-dist-na 999.0 APE11-dist-na 17.4062 APE10-dist-na 13.1956 APE9-dist-out 8.1123 None None None XRAY 1.894 0.212 0.236 A 271.0 255.0 13 29 16 13 [[402, 653]] 1.0 5fbo Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6X3OA Q06187 395 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2723 14.2227 BLBplus -137.77, 172.12 61.73, 21.35 -60.85, 127.83 37.95, 92.24 73.87, -6.38 out-out out 15.17 Saltbr-out 16.0811 HRD-in -75.67, -53.5 81.79, -14.06 out-out-out SNCooo out-out ActLoopNT-out 8.4586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -109.73, 7.42 APE9-dihe-in -70.0, 142.33 APE8-dihe-in -75.39, 64.77 APE8-rot-na 34.47 APE67-dihe-in -69.38, -11.52 -56.58, -43.22 APE12-dist-na 16.806 APE11-dist-na 18.6039 APE10-dist-na 13.6409 APE9-dist-out 8.5906 None None None XRAY 1.9 0.181 0.213 A 271.0 265.0 0 29 29 0 [[402, 653]] 1.0 6x3o Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6X3OB Q06187 393 659 659.0 ULY:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2875 14.0893 BLBplus -138.35, 171.76 61.86, 21.21 -60.49, 128.12 38.08, 92.33 72.6, -5.67 out-out out 15.3768 Saltbr-out 16.6794 HRD-in -75.8, -53.34 80.45, -11.96 out-out-out SNCooo out-out ActLoopNT-out 8.3968 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -114.41, 10.63 APE9-dihe-in -69.48, 144.31 APE8-dihe-in -76.78, 65.24 APE8-rot-na 34.23 APE67-dihe-in -70.15, -10.73 -56.21, -43.96 APE12-dist-na 16.68 APE11-dist-na 18.4631 APE10-dist-na 13.5744 APE9-dist-out 8.483 None None None XRAY 1.9 0.181 0.213 B 271.0 267.0 0 29 29 0 [[402, 653]] 1.0 6x3o Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK

Ligand: 5WE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name