Ligand: 5W2

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6VNLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNLA O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.3265 13.7702 ABAminus -119.32, -0.49 -140.7, 133.57 -134.25, 25.52 297.74, 87.39 -65.79, -22.82 in-in in 8.3964 Saltbr-in 2.695 HRD-in -67.09, -49.12 77.88, -9.34 in-in-in SNCiii in-in ActLoopNT-in 2.7725 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.51, 153.05 APE9-dihe-in -134.74, 140.01 APE8-dihe-in -75.65, 76.24 APE8-rot-na 30.79 APE67-dihe-in -80.53, -2.68 -63.26, -24.89 APE12-dist-na 9.5451 APE11-dist-na 10.9349 APE10-dist-na 12.071 APE9-dist-in 7.6759 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLB O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.2668 13.7032 ABAminus -120.39, -1.24 -140.56, 133.69 -134.27, 25.09 300.22, 88.0 -65.36, -23.57 in-in in 8.3499 Saltbr-in 2.4854 HRD-in -66.32, -49.37 78.14, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.03, 146.85 APE9-dihe-in -140.64, 128.61 APE8-dihe-in -81.75, 76.62 APE8-rot-na 30.24 APE67-dihe-in -80.98, -3.76 -62.39, -26.5 APE12-dist-na 8.5061 APE11-dist-na 9.9406 APE10-dist-na 8.9713 APE9-dist-in 6.9887 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 B 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLC O60674 842 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.0339 13.4464 ABAminus -118.65, -2.25 -143.32, 137.65 -132.09, 28.15 298.49, 86.48 -64.1, -24.5 in-in in 8.5872 Saltbr-in 2.6291 HRD-in -67.65, -48.53 76.35, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.8291 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.17, 150.96 APE9-dihe-in -134.19, 139.06 APE8-dihe-in -75.25, 71.72 APE8-rot-na 30.81 APE67-dihe-in -79.64, -2.96 -65.81, -24.18 APE12-dist-na 13.3697 APE11-dist-na 12.5418 APE10-dist-na 13.3206 APE9-dist-out 8.4582 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 C 308.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLD O60674 843 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.1249 13.445 ABAminus -118.2, -3.11 -143.32, 139.15 -131.54, 28.79 298.46, 86.52 -63.72, -23.5 in-in in 8.4533 Saltbr-in 2.4992 HRD-in -67.45, -48.99 77.0, -9.54 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.97, 152.24 APE9-dihe-in -132.29, 144.67 APE8-dihe-in -70.93, 73.22 APE8-rot-na 30.09 APE67-dihe-in -80.02, -3.29 -64.41, -24.13 APE12-dist-na 13.607 APE11-dist-na 12.4315 APE10-dist-na 13.3928 APE9-dist-out 8.0449 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 D 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 5W2

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6VNLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNLA O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.3265 13.7702 ABAminus -119.32, -0.49 -140.7, 133.57 -134.25, 25.52 297.74, 87.39 -65.79, -22.82 in-in in 8.3964 Saltbr-in 2.695 HRD-in -67.09, -49.12 77.88, -9.34 in-in-in SNCiii in-in ActLoopNT-in 2.7725 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.51, 153.05 APE9-dihe-in -134.74, 140.01 APE8-dihe-in -75.65, 76.24 APE8-rot-na 30.79 APE67-dihe-in -80.53, -2.68 -63.26, -24.89 APE12-dist-na 9.5451 APE11-dist-na 10.9349 APE10-dist-na 12.071 APE9-dist-in 7.6759 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLB O60674 840 1132 1132.0 5W2:61201 Type1 Inactive DFGin 6.2668 13.7032 ABAminus -120.39, -1.24 -140.56, 133.69 -134.27, 25.09 300.22, 88.0 -65.36, -23.57 in-in in 8.3499 Saltbr-in 2.4854 HRD-in -66.32, -49.37 78.14, -8.52 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.03, 146.85 APE9-dihe-in -140.64, 128.61 APE8-dihe-in -81.75, 76.62 APE8-rot-na 30.24 APE67-dihe-in -80.98, -3.76 -62.39, -26.5 APE12-dist-na 8.5061 APE11-dist-na 9.9406 APE10-dist-na 8.9713 APE9-dist-in 6.9887 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 B 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLC O60674 842 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.0339 13.4464 ABAminus -118.65, -2.25 -143.32, 137.65 -132.09, 28.15 298.49, 86.48 -64.1, -24.5 in-in in 8.5872 Saltbr-in 2.6291 HRD-in -67.65, -48.53 76.35, -9.72 in-in-out SNCiio in-out ActLoopNT-in 2.8291 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -78.17, 150.96 APE9-dihe-in -134.19, 139.06 APE8-dihe-in -75.25, 71.72 APE8-rot-na 30.81 APE67-dihe-in -79.64, -2.96 -65.81, -24.18 APE12-dist-na 13.3697 APE11-dist-na 12.5418 APE10-dist-na 13.3206 APE9-dist-out 8.4582 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 C 308.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNLD O60674 843 1131 1132.0 5W2:61201 Type1 Inactive DFGin 6.1249 13.445 ABAminus -118.2, -3.11 -143.32, 139.15 -131.54, 28.79 298.46, 86.52 -63.72, -23.5 in-in in 8.4533 Saltbr-in 2.4992 HRD-in -67.45, -48.99 77.0, -9.54 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.97, 152.24 APE9-dihe-in -132.29, 144.67 APE8-dihe-in -70.93, 73.22 APE8-rot-na 30.09 APE67-dihe-in -80.02, -3.29 -64.41, -24.13 APE12-dist-na 13.607 APE11-dist-na 12.4315 APE10-dist-na 13.3928 APE9-dist-out 8.0449 None PTR1007 PTR1007 XRAY 2.4 0.218 0.257 D 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnl Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 5W2

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name