Ligand: 5JG

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% 6ZCRA
DFGin ABAminus 1 25.0% 5E1EB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 5E1EB P23458 865 1154 1154.0 5JG:1201 Type1 Inactive DFGin 6.6155 13.7027 ABAminus -133.31, 28.19 -149.71, 114.81 -114.53, 26.1 291.32, 84.42 -63.72, -24.05 in-in in 7.7649 Saltbr-in 2.7841 HRD-in -74.91, -42.75 64.28, 0.85 in-in-out SNCiio in-out ActLoopNT-in 2.8012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.64, 38.4 APE9-dihe-in -74.25, 132.21 APE8-dihe-in -79.08, 75.2 APE8-rot-na 22.34 APE67-dihe-in -75.56, -2.49 -52.66, -36.06 APE12-dist-na 10.8574 APE11-dist-na 13.3108 APE10-dist-na 10.0385 APE9-dist-in 6.8736 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 B 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5E1EA P23458 865 1154 1154.0 5JG:1202 Type1 Inactive DFGin 6.6436 13.9325 BLAminus -119.33, -177.28 50.16, 87.79 -101.77, 31.05 290.94, 82.42 -65.82, -24.94 in-in in 7.8719 Saltbr-in 2.7937 HRD-in -75.04, -43.37 64.83, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.8156 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.99, 41.3 APE9-dihe-in -73.96, 132.79 APE8-dihe-in -79.05, 75.13 APE8-rot-na 22.09 APE67-dihe-in -75.65, -2.64 -52.7, -35.87 APE12-dist-na 10.9808 APE11-dist-na 12.9477 APE10-dist-na 10.1677 APE9-dist-in 6.9083 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 A 290.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR SYK KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcr TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcu TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 5JG

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% 6ZCRA
DFGin ABAminus 1 25.0% 5E1EB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 5E1EB P23458 865 1154 1154.0 5JG:1201 Type1 Inactive DFGin 6.6155 13.7027 ABAminus -133.31, 28.19 -149.71, 114.81 -114.53, 26.1 291.32, 84.42 -63.72, -24.05 in-in in 7.7649 Saltbr-in 2.7841 HRD-in -74.91, -42.75 64.28, 0.85 in-in-out SNCiio in-out ActLoopNT-in 2.8012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.64, 38.4 APE9-dihe-in -74.25, 132.21 APE8-dihe-in -79.08, 75.2 APE8-rot-na 22.34 APE67-dihe-in -75.56, -2.49 -52.66, -36.06 APE12-dist-na 10.8574 APE11-dist-na 13.3108 APE10-dist-na 10.0385 APE9-dist-in 6.8736 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 B 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5E1EA P23458 865 1154 1154.0 5JG:1202 Type1 Inactive DFGin 6.6436 13.9325 BLAminus -119.33, -177.28 50.16, 87.79 -101.77, 31.05 290.94, 82.42 -65.82, -24.94 in-in in 7.8719 Saltbr-in 2.7937 HRD-in -75.04, -43.37 64.83, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.8156 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.99, 41.3 APE9-dihe-in -73.96, 132.79 APE8-dihe-in -79.05, 75.13 APE8-rot-na 22.09 APE67-dihe-in -75.65, -2.64 -52.7, -35.87 APE12-dist-na 10.9808 APE11-dist-na 12.9477 APE10-dist-na 10.1677 APE9-dist-in 6.9083 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 A 290.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR SYK KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcr Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.6911 14.6157 BLAminus -131.25, -174.99 58.52, 82.29 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.0047 Saltbr-in 2.9213 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.8035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7148 None None None XRAY 1.73 0.189 0.218 A 299.0 264.0 9 31 27 4 [[370, 628]] 1.0 6zcu Homo sapiens TYR_SYK_HUMAN TYR 6.1e-90 307.0 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 5JG

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name