Ligand: 585 (Tamatinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3FQSA
DFGin None 1 50.0% 3PIYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.59 14.805 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.6 Saltbr-out 6.166 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.12 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.754 APE11-dist-na 17.73 APE10-dist-na 12.439 APE9-dist-out 8.177 None None None XRAY 2.55 0.228 0.295 A 274 262 6 0 0 0 [[402, 653]] 1.0 3piy TYR_BTK_HUMAN TYR 6.3e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR SYK KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-in 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 585 (Tamatinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3FQSA
DFGin None 1 50.0% 3PIYA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 3PIYA Q06187 391 658 659.0 585:1 Type1 Inactive DFGin 6.59 14.805 None -86.48, 116.32 -39.12, -55.85 -103.57, 159.77 292.78, 91.05 -55.45, 135.27 out-out out 10.6 Saltbr-out 6.166 HRD-in -82.22, -47.83 77.57, -19.27 out-out-out SNCooo out-out ActLoopNT-out 14.12 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -101.57, 20.38 APE9-dihe-in -77.53, 136.74 APE8-dihe-in -77.13, 67.95 APE8-rot-na 32.82 APE67-dihe-in -63.75, -20.32 -55.08, -51.26 APE12-dist-na 17.754 APE11-dist-na 17.73 APE10-dist-na 12.439 APE9-dist-out 8.177 None None None XRAY 2.55 0.228 0.295 A 274 262 6 0 0 0 [[402, 653]] 1.0 3piy Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR SYK KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus -130.1, -168.06 51.07, 81.04 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-in 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: 585 (Tamatinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name