Ligand: 1RS

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4F08A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4F08A O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.4218 13.4486 ABAminus -118.75, 17.84 -162.68, 140.07 -138.8, 36.17 302.12, 78.28 -60.82, -32.25 in-in in 8.3468 Saltbr-in 2.9601 HRD-in -65.4, -47.08 70.33, 4.13 in-in-in SNCiii in-in ActLoopNT-in 2.7158 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.27, 131.17 APE9-dihe-in -120.61, 142.32 APE8-dihe-in -71.84, 61.3 APE8-rot-na 27.63 APE67-dihe-in -74.77, -5.24 -55.3, -29.19 APE12-dist-na 12.333 APE11-dist-na 13.3974 APE10-dist-na 12.8567 APE9-dist-in 7.9556 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 A 302.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4f08 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4F08B O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.5157 13.4196 ABAminus -124.31, 17.64 -159.69, 141.63 -138.77, 37.19 300.52, 77.4 -63.7, -27.82 in-in in 8.3342 Saltbr-in 2.9166 HRD-in -64.42, -45.84 68.41, 15.3 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.79, 144.81 APE9-dihe-in -113.89, 127.58 APE8-dihe-in -71.3, 63.33 APE8-rot-na 27.17 APE67-dihe-in -75.09, -5.44 -57.05, -30.14 APE12-dist-na 8.1199 APE11-dist-na 9.253 APE10-dist-na 11.287 APE9-dist-in 7.9318 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 B 302.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4f08 TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 1RS

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4F08A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4F08A O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.4218 13.4486 ABAminus -118.75, 17.84 -162.68, 140.07 -138.8, 36.17 302.12, 78.28 -60.82, -32.25 in-in in 8.3468 Saltbr-in 2.9601 HRD-in -65.4, -47.08 70.33, 4.13 in-in-in SNCiii in-in ActLoopNT-in 2.7158 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.27, 131.17 APE9-dihe-in -120.61, 142.32 APE8-dihe-in -71.84, 61.3 APE8-rot-na 27.63 APE67-dihe-in -74.77, -5.24 -55.3, -29.19 APE12-dist-na 12.333 APE11-dist-na 13.3974 APE10-dist-na 12.8567 APE9-dist-in 7.9556 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 A 302.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4f08 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4F08B O60674 843 1132 1132.0 1RS:1201 Type1 Inactive DFGin 6.5157 13.4196 ABAminus -124.31, 17.64 -159.69, 141.63 -138.77, 37.19 300.52, 77.4 -63.7, -27.82 in-in in 8.3342 Saltbr-in 2.9166 HRD-in -64.42, -45.84 68.41, 15.3 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.79, 144.81 APE9-dihe-in -113.89, 127.58 APE8-dihe-in -71.3, 63.33 APE8-rot-na 27.17 APE67-dihe-in -75.09, -5.44 -57.05, -30.14 APE12-dist-na 8.1199 APE11-dist-na 9.253 APE10-dist-na 11.287 APE9-dist-in 7.9318 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.82 0.214 0.241 B 302.0 290.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4f08 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 1RS

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name