Ligand: 0X2

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4GFMA
DFGin BLAminus 1 50.0% 4GFOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4GFMA O60674 840 1130 1132.0 0X2:1201 Type1 Inactive DFGin 6.2178 13.6172 ABAminus -121.44, -7.12 -143.9, 139.81 -132.81, 29.99 295.23, 86.37 -67.0, -21.6 in-in in 8.4202 Saltbr-in 3.0645 HRD-in -69.73, -44.15 65.44, -8.11 in-in-in SNCiii in-in ActLoopNT-in 2.7184 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 128.5 APE9-dihe-in -126.85, 127.41 APE8-dihe-in -79.98, 73.49 APE8-rot-na 29.58 APE67-dihe-in -75.78, -2.18 -60.58, -27.16 APE12-dist-na 10.9516 APE11-dist-na 9.7162 APE10-dist-na 9.9268 APE9-dist-in 7.0287 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.171 0.242 A 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4gfm TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 4GFOA P29597 890 1176 1187.0 0X2:61206 Type1 Inactive DFGin 6.5446 13.8153 BLAminus -119.78, -165.53 41.83, 76.86 -90.36, 18.77 286.1, 84.92 -57.97, -31.66 in-out in 8.5061 Saltbr-out 3.8229 HRD-in -83.33, -51.5 65.48, 12.02 out-in-in SNCoii in-in ActLoopNT-in 2.9222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 60.25 APE9-dihe-in -120.27, 150.37 APE8-dihe-in -75.99, 77.21 APE8-rot-na 30.46 APE67-dihe-in -74.83, -3.18 -56.44, -30.73 APE12-dist-na 11.8084 APE11-dist-na 11.2748 APE10-dist-na 9.4613 APE9-dist-in 5.8911 D1023N None None XRAY 2.3 0.237 0.287 A 302.0 270.0 17 31 31 0 [[589, 868], [897, 1171]] 2.0 4gfo TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: 0X2

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 4GFMA
DFGin BLAminus 1 50.0% 4GFOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4GFMA O60674 840 1130 1132.0 0X2:1201 Type1 Inactive DFGin 6.2178 13.6172 ABAminus -121.44, -7.12 -143.9, 139.81 -132.81, 29.99 295.23, 86.37 -67.0, -21.6 in-in in 8.4202 Saltbr-in 3.0645 HRD-in -69.73, -44.15 65.44, -8.11 in-in-in SNCiii in-in ActLoopNT-in 2.7184 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.82, 128.5 APE9-dihe-in -126.85, 127.41 APE8-dihe-in -79.98, 73.49 APE8-rot-na 29.58 APE67-dihe-in -75.78, -2.18 -60.58, -27.16 APE12-dist-na 10.9516 APE11-dist-na 9.7162 APE10-dist-na 9.9268 APE9-dist-in 7.0287 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.3 0.171 0.242 A 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4gfm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.3 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 4GFOA P29597 890 1176 1187.0 0X2:61206 Type1 Inactive DFGin 6.5446 13.8153 BLAminus -119.78, -165.53 41.83, 76.86 -90.36, 18.77 286.1, 84.92 -57.97, -31.66 in-out in 8.5061 Saltbr-out 3.8229 HRD-in -83.33, -51.5 65.48, 12.02 out-in-in SNCoii in-in ActLoopNT-in 2.9222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 60.25 APE9-dihe-in -120.27, 150.37 APE8-dihe-in -75.99, 77.21 APE8-rot-na 30.46 APE67-dihe-in -74.83, -3.18 -56.44, -30.73 APE12-dist-na 11.8084 APE11-dist-na 11.2748 APE10-dist-na 9.4613 APE9-dist-in 5.8911 D1023N None None XRAY 2.3 0.237 0.287 A 302.0 270.0 17 31 31 0 [[589, 868], [897, 1171]] 2.0 4gfo Homo sapiens TYR_TYK2-2_HUMAN TYR 2.2e-81 278.9 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: 0X2

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name