Ligand: 0NV

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4E6QA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK2-2 JAK2_HUMAN 4E6QA 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E6QB 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2

Ligand: 0NV

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4E6QA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK2-2 JAK2_HUMAN 4E6QA 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 4E6QB 1.948 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao 0NV Type1 835 - 1132 0 PTR1007,PTR1008 Q853R,Y931F,D939E Tyrosine-protein kinase JAK2 Homo sapiens

Ligand: 0NV

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism