Ligand: 0NH

Total number of chains: 7
Active chains: 4
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 57.1% 4E4MA
DFGin ABAminus 3 42.9% 4E4LD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR JAK1-2 JAK1_HUMAN 4E4LA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LB 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LD 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
TYR JAK2-2 JAK2_HUMAN 4E4MA 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MB 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4MD 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4E4ME 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2

Ligand: 0NH

Total number of chains: 7
Active chains: 4
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 57.1% 4E4MA
DFGin ABAminus 3 42.9% 4E4LD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR JAK1-2 JAK1_HUMAN 4E4LA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-2 JAK1_HUMAN 4E4LB 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK1-2 JAK1_HUMAN 4E4LD 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 4E4MA 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 4E4MB 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 4E4MD 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-2 JAK2_HUMAN 4E4ME 2.25 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0NH Type1 835 - 1132 0 PTR1007,PTR1008 None Tyrosine-protein kinase JAK2 Homo sapiens

Ligand: 0NH

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism