Ligand: 07J (Infigratinib, Truseltiq)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 100.0% 3TT0A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 3TT0A P11362 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.254 13.639 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.915 Saltbr-in 3.106 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.614 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.102 APE11-dist-na 19.47 APE10-dist-na 16.731 APE9-dist-out 11.071 C584S None None XRAY 2.8 0.207 0.261 A 382 305 0 0 0 0 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3TT0B P11362 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.382 13.307 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.848 Saltbr-in 3.041 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382 272 33 0 0 17 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: 07J (Infigratinib, Truseltiq)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 100.0% 3TT0A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 3TT0A P11362 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.254 13.639 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.915 Saltbr-in 3.106 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.614 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.102 APE11-dist-na 19.47 APE10-dist-na 16.731 APE9-dist-out 11.071 C584S None None XRAY 2.8 0.207 0.261 A 382 305 0 0 0 0 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3TT0B P11362 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.382 13.307 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.848 Saltbr-in 3.041 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382 272 33 0 0 17 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: 07J (Infigratinib, Truseltiq)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name