TYR_ZAP70 (Tyrosine-protein kinase ZAP-70)

Total number of chains: 5
Active chains: 2
Uniprot: ZAP70_HUMAN
Kinase Domain Residues: 337 - 595
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% AF-P43403-K1A
DFGin BLAplus 2 40.0% 2OZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ZAP70 AF-P43403-K1A P43403 329 603 619.0 No_ligand No_ligand Active DFGin 6.1878 14.4197 BLAminus -137.98, 179.44 59.55, 78.1 -93.01, 15.77 290.18, 85.07 -60.01, -36.22 in-in in 8.3628 Saltbr-in 2.6988 HRD-in -76.89, -45.73 61.88, -0.21 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.02 APE9-dihe-in -91.5, 142.64 APE8-dihe-in -76.17, 66.29 APE8-rot-na 35.97 APE67-dihe-in -69.86, -18.7 -49.71, -32.12 APE12-dist-na 13.3382 APE11-dist-na 9.9543 APE10-dist-na 10.3959 APE9-dist-in 6.7938 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 31 31 0 [[338, 595]] 1.0 AF-P43403-K1 TYR_ZAP70_HUMAN TYR 2.1e-90 308.5 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 AF-P43403-K3A P43403 329 603 619.0 No_ligand No_ligand Active DFGin 6.0917 14.3211 BLAminus -143.27, -178.47 58.96, 69.92 -83.21, 12.6 291.81, 90.1 -58.13, -35.44 in-in in 8.2775 Saltbr-in 2.7119 HRD-in -75.54, -48.5 65.02, 2.01 in-in-in SNCiii in-in ActLoopNT-in 2.9178 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.24, 90.31 APE9-dihe-in -102.47, 145.15 APE8-dihe-in -75.42, 63.45 APE8-rot-na 38.13 APE67-dihe-in -71.05, -17.75 -50.73, -29.5 APE12-dist-na 13.6053 APE11-dist-na 10.0293 APE10-dist-na 10.3186 APE9-dist-in 6.7286 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 31 31 0 [[338, 595]] 1.0 AF-P43403-K3 TYR_ZAP70_HUMAN TYR 2.1e-90 308.5 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.4492 14.6547 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.5451 Saltbr-in 2.6048 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.9844 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.4853 APE11-dist-na 13.5249 APE10-dist-na 14.7003 APE9-dist-out 9.0998 None None None XRAY 2.3 0.217 0.271 A 287.0 276.0 3 31 31 0 [[338, 595]] 1.0 1u59 TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.8971 12.8886 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.1822 Saltbr-out 12.4812 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5295 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613.0 538.0 14 31 17 14 [[338, 595]] 1.0 2ozo TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.9276 12.4383 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.1129 Saltbr-out 13.9854 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.2697 D461N None None XRAY 3.0 0.213 0.287 A 614.0 543.0 17 31 14 17 [[338, 595]] 1.0 4k2r TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

TYR_ZAP70 (Tyrosine-protein kinase ZAP-70)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% AF-P43403-K1A
DFGin BLAplus 2 40.0% 2OZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ZAP70 ZAP70_HUMAN AF-P43403-K1A P43403 329 603 619.0 No_ligand No_ligand Active DFGin 6.1878 14.4197 BLAminus -137.98, 179.44 59.55, 78.1 -93.01, 15.77 290.18, 85.07 -60.01, -36.22 in-in in 8.3628 Saltbr-in 2.6988 HRD-in -76.89, -45.73 61.88, -0.21 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 86.02 APE9-dihe-in -91.5, 142.64 APE8-dihe-in -76.17, 66.29 APE8-rot-na 35.97 APE67-dihe-in -69.86, -18.7 -49.71, -32.12 APE12-dist-na 13.3382 APE11-dist-na 9.9543 APE10-dist-na 10.3959 APE9-dist-in 6.7938 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 31 31 0 [[338, 595]] 1.0 AF-P43403-K1 Homo sapiens TYR_ZAP70_HUMAN TYR 2.1e-90 308.5 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 ZAP70_HUMAN AF-P43403-K3A P43403 329 603 619.0 No_ligand No_ligand Active DFGin 6.0917 14.3211 BLAminus -143.27, -178.47 58.96, 69.92 -83.21, 12.6 291.81, 90.1 -58.13, -35.44 in-in in 8.2775 Saltbr-in 2.7119 HRD-in -75.54, -48.5 65.02, 2.01 in-in-in SNCiii in-in ActLoopNT-in 2.9178 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.24, 90.31 APE9-dihe-in -102.47, 145.15 APE8-dihe-in -75.42, 63.45 APE8-rot-na 38.13 APE67-dihe-in -71.05, -17.75 -50.73, -29.5 APE12-dist-na 13.6053 APE11-dist-na 10.0293 APE10-dist-na 10.3186 APE9-dist-in 6.7286 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 31 31 0 [[338, 595]] 1.0 AF-P43403-K3 Homo sapiens TYR_ZAP70_HUMAN TYR 2.1e-90 308.5 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 ZAP70_HUMAN 1U59A P43403 328 606 619.0 STU:60100 Type1 Inactive DFGin 6.4492 14.6547 BLAminus -132.39, 179.54 60.68, 79.94 -93.24, 26.52 286.21, 85.42 -61.36, -30.97 in-in in 8.5451 Saltbr-in 2.6048 HRD-in -75.34, -52.46 82.3, -36.8 in-in-out SNCiio in-out ActLoopNT-in 2.9844 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -109.77, 150.26 APE9-dihe-in -93.67, 137.73 APE8-dihe-in -75.36, 68.87 APE8-rot-na 32.83 APE67-dihe-in -59.55, -7.44 -43.09, -46.01 APE12-dist-na 14.4853 APE11-dist-na 13.5249 APE10-dist-na 14.7003 APE9-dist-out 9.0998 None None None XRAY 2.3 0.217 0.271 A 287.0 276.0 3 31 31 0 [[338, 595]] 1.0 1u59 Homo sapiens TYR_ZAP70_HUMAN TYR 2.5e-90 308.2 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 ZAP70_HUMAN 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.8971 12.8886 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.1822 Saltbr-out 12.4812 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5295 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613.0 538.0 14 31 17 14 [[338, 595]] 1.0 2ozo Homo sapiens TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
ZAP70 ZAP70_HUMAN 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.9276 12.4383 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.1129 Saltbr-out 13.9854 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.2697 D461N None None XRAY 3.0 0.213 0.287 A 614.0 543.0 17 31 14 17 [[338, 595]] 1.0 4k2r Homo sapiens TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

TYR_ZAP70 (Tyrosine-protein kinase ZAP-70)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name