TYR_TYK2-1 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 42
Active chains: 0
Family: TYR
Uniprot: TYK2_HUMAN
Kinase Domain Residues: 589 - 868
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 42 100.0% 8S9AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
5C03A 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.384 13.105 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.794 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.833 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.251 APE10-dist-na 16.457 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
5C03B 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.517 12.886 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.709 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.957 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.635 APE11-dist-na 12.304 APE10-dist-na 16.484 APE9-dist-out 11.221 None None None XRAY 1.9 0.183 0.218 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7AX4A 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.507 12.805 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.556 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.662 APE11-dist-na 12.284 APE10-dist-na 16.464 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7AX4B 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.488 12.776 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.496 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.325 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.807 APE11-dist-na 12.32 APE10-dist-na 16.542 APE9-dist-out 11.793 None None None XRAY 2.12 0.186 0.229 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S98A 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.353 12.698 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.676 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.77 APE11-dist-na 12.368 APE10-dist-na 16.501 APE9-dist-out 11.633 None None CSO808 XRAY 1.87 0.226 0.274 A 295 256 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S98B 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.339 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.696 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.466 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.967 APE11-dist-na 12.261 APE10-dist-na 16.539 APE9-dist-out 11.738 None None CSO808 XRAY 1.87 0.226 0.274 B 295 259 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S98C 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.558 12.819 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.615 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.572 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.932 APE11-dist-na 12.277 APE10-dist-na 16.512 APE9-dist-out 11.862 None None CSO808 XRAY 1.87 0.226 0.274 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S99A 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.399 12.782 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.659 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.33 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.928 APE11-dist-na 12.29 APE10-dist-na 16.586 APE9-dist-out 11.761 None None None XRAY 1.71 0.191 0.225 A 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S99B 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.443 12.614 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.557 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.426 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.909 APE11-dist-na 12.186 APE10-dist-na 16.471 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S99C 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.462 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.588 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.173 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.738 APE11-dist-na 12.432 APE10-dist-na 16.544 APE9-dist-out 11.684 None None None XRAY 1.71 0.191 0.225 C 295 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S9AA 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S9AB 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8S9AC 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
5TKDA 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.513 12.63 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.163 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.69 APE11-dist-na 12.22 APE10-dist-na 16.406 APE9-dist-out 11.578 None None None XRAY 1.92 0.193 0.215 A 298 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
5TKDB 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.534 12.489 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.422 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.666 APE11-dist-na 12.184 APE10-dist-na 16.381 APE9-dist-out 11.457 None None None XRAY 1.92 0.193 0.215 B 298 247 41 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
3ZONA 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.368 12.762 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.655 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.36 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.31 APE10-dist-na 16.62 APE9-dist-out 11.977 None None None XRAY 2.15 0.217 0.268 A 335 261 33 0 0 0 [[589, 868], [897, 1171]] 2.0 3zon TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZRA 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.777 12.781 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.435 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.095 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.712 APE11-dist-na 12.195 APE10-dist-na 16.359 APE9-dist-out 11.553 None None None XRAY 2.56 0.19 0.229 A 317 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZRB 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.794 12.735 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.371 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.164 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.706 APE11-dist-na 12.223 APE10-dist-na 16.378 APE9-dist-out 11.55 None None None XRAY 2.56 0.19 0.229 B 317 259 30 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
4WOVA 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.612 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.434 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.472 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.865 APE11-dist-na 12.155 APE10-dist-na 16.373 APE9-dist-out 11.62 None None None XRAY 1.8 0.193 0.214 A 317 258 32 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
4WOVB 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.375 12.564 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.386 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.54 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.828 APE11-dist-na 12.112 APE10-dist-na 16.313 APE9-dist-out 11.656 None None None XRAY 1.8 0.193 0.214 B 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NSLA 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.447 12.627 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.45 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.722 APE11-dist-na 12.197 APE10-dist-na 16.413 APE9-dist-out 11.7 None None None XRAY 2.15 0.203 0.213 A 317 251 37 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NSLB 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.466 12.543 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.423 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.241 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.667 APE11-dist-na 12.177 APE10-dist-na 16.391 APE9-dist-out 11.568 None None None XRAY 2.15 0.203 0.213 B 317 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZEA 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.517 12.327 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.127 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.814 APE11-dist-na 12.241 APE10-dist-na 16.458 APE9-dist-out 11.439 None None None XRAY 1.96 0.197 0.227 A 317 250 38 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZEB 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.51 12.331 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.336 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.073 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.732 APE11-dist-na 12.151 APE10-dist-na 16.38 APE9-dist-out 11.416 None None None XRAY 1.96 0.197 0.227 B 317 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZFA 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.6 12.671 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.401 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.808 APE11-dist-na 12.262 APE10-dist-na 16.517 APE9-dist-out 11.623 None None None XRAY 2.39 0.205 0.231 A 317 247 42 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZFB 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.67 12.598 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.372 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.752 APE11-dist-na 12.229 APE10-dist-na 16.478 APE9-dist-out 11.555 None None None XRAY 2.39 0.205 0.231 B 317 248 41 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZHA 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.406 12.772 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.775 APE11-dist-na 12.229 APE10-dist-na 16.47 APE9-dist-out 11.317 None None None XRAY 2.73 0.193 0.215 A 317 249 39 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZHB 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.599 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.376 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.308 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.735 APE11-dist-na 12.216 APE10-dist-na 16.437 APE9-dist-out 11.269 None None None XRAY 2.73 0.193 0.215 B 317 249 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZPA 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.216 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.307 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.154 APE9-dist-out 11.555 None None None XRAY 2.35 0.191 0.238 A 317 259 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZPB 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.457 12.377 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.288 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.247 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.773 APE11-dist-na 12.02 APE10-dist-na 16.21 APE9-dist-out 11.556 None None None XRAY 2.35 0.191 0.238 B 317 260 29 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZQA 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.504 12.4 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.039 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.881 APE11-dist-na 12.092 APE10-dist-na 16.368 APE9-dist-out 11.72 None None None XRAY 2.11 0.199 0.237 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
6NZQB 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.552 12.37 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.958 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.442 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.911 APE11-dist-na 12.088 APE10-dist-na 16.439 APE9-dist-out 11.694 None None None XRAY 2.11 0.199 0.237 B 317 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7K7OA 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.366 12.565 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.266 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.181 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.765 APE11-dist-na 12.088 APE10-dist-na 16.266 APE9-dist-out 11.763 None None None XRAY 2.82 0.181 0.252 A 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7K7OB 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.723 12.247 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.923 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.628 APE11-dist-na 12.199 APE10-dist-na 16.268 APE9-dist-out 11.283 None None None XRAY 2.82 0.181 0.252 B 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7K7QA 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.543 12.533 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.281 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.398 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.824 APE11-dist-na 12.119 APE10-dist-na 16.488 APE9-dist-out 11.802 None None None XRAY 2.27 0.191 0.215 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
7K7QB 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.528 12.484 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.264 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.785 APE11-dist-na 12.127 APE10-dist-na 16.459 APE9-dist-out 11.701 None None None XRAY 2.27 0.191 0.215 B 317 251 38 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8TB5A 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.575 12.828 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.628 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.033 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.966 APE11-dist-na 12.452 APE10-dist-na 16.637 APE9-dist-out 11.819 None None None XRAY 2.32 0.187 0.243 A 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8TB5B 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.354 12.83 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.655 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.02 APE11-dist-na 12.281 APE10-dist-na 16.5 APE9-dist-out 11.726 None None None XRAY 2.32 0.187 0.243 B 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8TB6A 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.519 12.918 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.757 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.67 APE11-dist-na 12.214 APE10-dist-na 16.343 APE9-dist-out 11.339 None None None XRAY 1.96 0.195 0.236 A 326 263 33 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
8TB6B 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.575 12.834 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.746 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.116 APE10-dist-na 16.334 APE9-dist-out 11.431 None None None XRAY 1.96 0.195 0.236 B 326 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
5C01A 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.494 12.953 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.86 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.035 APE11-dist-na 12.558 APE10-dist-na 16.715 APE9-dist-out 11.348 None None None XRAY 2.15 0.197 0.24 A 342 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
5C01B 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.99 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.846 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.989 APE11-dist-na 12.592 APE10-dist-na 16.738 APE9-dist-out 11.636 None None None XRAY 2.15 0.197 0.24 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

TYR_TYK2-1 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 42
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 42 100.0% 8S9AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYK2_HUMAN 5C03A P29597 579 869 1187.0 AGS:901 ATPlike Pseudo DFGin 7.384 13.105 None -83.93, 173.19 -65.21, 161.12 -79.17, -4.85 20.2, 153.73 66.68, -148.85 in-na in 9.794 Saltbr-na 999.0 HRD-in -90.34, -65.69 85.25, 3.79 na-out-out SNCaoo out-out ActLoopNT-out 7.833 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.44, -38.84 APE9-dihe-out -63.06, -21.54 APE8-dihe-out -87.7, -1.06 APE8-rot-na 196.81 APE67-dihe-out -97.84, 8.94 -69.26, 133.75 APE12-dist-na 10.117 APE11-dist-na 12.251 APE10-dist-na 16.457 APE9-dist-out 11.202 None None None XRAY 1.9 0.183 0.218 A 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5C03B P29597 580 870 1187.0 AGS:901 ATPlike Pseudo DFGin 7.517 12.886 None -71.74, 164.11 -66.43, 161.04 -81.86, 0.59 24.73, 148.49 67.14, -147.92 in-na in 9.709 Saltbr-na 999.0 HRD-in -90.78, -63.58 88.98, 2.52 na-out-out SNCaoo out-out ActLoopNT-out 7.957 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.24, -42.55 APE9-dihe-out -56.38, -27.94 APE8-dihe-out -85.13, -4.16 APE8-rot-na 194.3 APE67-dihe-out -97.21, 10.32 -66.64, 134.88 APE12-dist-na 9.635 APE11-dist-na 12.304 APE10-dist-na 16.484 APE9-dist-out 11.221 None None None XRAY 1.9 0.183 0.218 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c03 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7AX4A P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.507 12.805 None -76.81, 166.44 -58.43, 152.23 -70.05, -8.8 24.77, 146.14 76.34, -154.15 in-na in 9.556 Saltbr-na 999.0 HRD-in -86.69, -61.89 82.12, 4.68 na-out-out SNCaoo out-out ActLoopNT-out 8.232 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.65, -45.17 APE9-dihe-out -58.59, -27.02 APE8-dihe-out -78.56, -9.63 APE8-rot-na 222.71 APE67-dihe-out -95.98, 6.87 -68.07, 131.63 APE12-dist-na 9.662 APE11-dist-na 12.284 APE10-dist-na 16.464 APE9-dist-out 11.658 None None None XRAY 2.12 0.186 0.229 A 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7AX4B P29597 579 868 1187.0 NM7:2000 Type1 Pseudo DFGin 7.488 12.776 None -74.88, 165.0 -57.44, 152.12 -71.28, -8.27 25.03, 145.7 75.91, -154.77 in-na in 9.496 Saltbr-na 999.0 HRD-in -85.26, -61.54 83.16, 3.63 na-out-out SNCaoo out-out ActLoopNT-out 8.325 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.51, -41.43 APE9-dihe-out -63.74, -26.18 APE8-dihe-out -77.76, -6.82 APE8-rot-na 221.04 APE67-dihe-out -90.97, 8.23 -71.21, 136.1 APE12-dist-na 9.807 APE11-dist-na 12.32 APE10-dist-na 16.542 APE9-dist-out 11.793 None None None XRAY 2.12 0.186 0.229 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 7ax4 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.353 12.698 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.676 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.115 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.77 APE11-dist-na 12.368 APE10-dist-na 16.501 APE9-dist-out 11.633 None None CSO808 XRAY 1.87 0.226 0.274 A 295 256 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.339 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.696 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.466 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.967 APE11-dist-na 12.261 APE10-dist-na 16.539 APE9-dist-out 11.738 None None CSO808 XRAY 1.87 0.226 0.274 B 295 259 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.558 12.819 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.615 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.572 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.932 APE11-dist-na 12.277 APE10-dist-na 16.512 APE9-dist-out 11.862 None None CSO808 XRAY 1.87 0.226 0.274 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S99A P29597 578 868 1187.0 ZS3:901 Type1 Pseudo DFGin 7.399 12.782 None -62.82, 155.3 -51.38, 147.9 -74.24, -0.55 28.63, 142.53 65.17, -151.12 in-na in 9.659 Saltbr-na 999.0 HRD-in -82.17, -60.98 83.64, 7.23 na-out-out SNCaoo out-out ActLoopNT-out 8.33 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -62.74, -38.21 APE9-dihe-out -59.13, -29.8 APE8-dihe-out -88.76, 1.4 APE8-rot-na 298.32 APE67-dihe-out -97.29, 12.8 -68.06, 135.28 APE12-dist-na 9.928 APE11-dist-na 12.29 APE10-dist-na 16.586 APE9-dist-out 11.761 None None None XRAY 1.71 0.191 0.225 A 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S99B P29597 579 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.443 12.614 None -56.5, 153.96 -51.89, 147.7 -74.35, -1.31 29.46, 140.64 65.58, -151.37 in-na in 9.557 Saltbr-na 999.0 HRD-in -80.48, -58.61 84.39, 4.19 na-out-out SNCaoo out-out ActLoopNT-out 8.426 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.04, -40.63 APE9-dihe-out -58.98, -25.02 APE8-dihe-out -89.21, 1.32 APE8-rot-na 294.34 APE67-dihe-out -101.31, 17.67 -66.15, 136.61 APE12-dist-na 9.909 APE11-dist-na 12.186 APE10-dist-na 16.471 APE9-dist-out 11.849 None None None XRAY 1.71 0.191 0.225 B 295 261 29 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S99C P29597 578 867 1187.0 ZS3:901 Type1 Pseudo DFGin 7.462 12.589 None -61.71, 157.01 -52.78, 147.81 -73.85, -0.24 30.37, 137.25 70.68, -153.5 in-na in 9.588 Saltbr-na 999.0 HRD-in -82.08, -63.18 88.21, 6.86 na-out-out SNCaoo out-out ActLoopNT-out 8.173 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.66, -43.16 APE9-dihe-out -54.27, -29.75 APE8-dihe-out -91.84, 3.24 APE8-rot-na 295.26 APE67-dihe-out -102.57, 13.29 -66.4, 134.15 APE12-dist-na 9.738 APE11-dist-na 12.432 APE10-dist-na 16.544 APE9-dist-out 11.684 None None None XRAY 1.71 0.191 0.225 C 295 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 8s99 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5TKDA P29597 581 866 1187.0 7GL:901 Type1 Pseudo DFGin 7.513 12.63 None -67.32, 165.44 -61.21, 150.11 -77.85, 2.5 30.62, 144.39 70.23, -152.17 in-na in 9.487 Saltbr-na 999.0 HRD-in -86.12, -60.06 82.4, 7.11 na-out-out SNCaoo out-out ActLoopNT-out 8.163 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.41, -39.74 APE9-dihe-out -61.67, -21.18 APE8-dihe-out -86.78, -7.05 APE8-rot-na 289.65 APE67-dihe-out -93.06, 5.59 -69.25, 133.26 APE12-dist-na 9.69 APE11-dist-na 12.22 APE10-dist-na 16.406 APE9-dist-out 11.578 None None None XRAY 1.92 0.193 0.215 A 298 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5TKDB P29597 581 867 1187.0 7GL:901 Type1 Pseudo DFGin 7.534 12.489 None -66.93, 165.19 -61.5, 149.63 -77.96, 1.32 30.48, 144.44 72.41, -154.16 in-na in 9.422 Saltbr-na 999.0 HRD-in -86.72, -59.64 79.99, 10.31 na-out-out SNCaoo out-out ActLoopNT-out 8.029 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.45, -40.77 APE9-dihe-out -60.64, -23.02 APE8-dihe-out -86.44, -3.61 APE8-rot-na 200.95 APE67-dihe-out -92.39, 6.26 -73.47, 133.63 APE12-dist-na 9.666 APE11-dist-na 12.184 APE10-dist-na 16.381 APE9-dist-out 11.457 None None None XRAY 1.92 0.193 0.215 B 298 247 41 0 0 0 [[589, 868], [897, 1171]] 2.0 5tkd Homo sapiens TYR_TYK2-1_HUMAN TYR 4.2e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 3ZONA P29597 577 870 1187.0 IK1:1871 Type1 Pseudo DFGin 7.368 12.762 None -83.03, 173.2 -63.77, 153.55 -76.54, -5.77 26.47, 146.49 67.78, -154.99 in-na in 9.655 Saltbr-na 999.0 HRD-in -77.23, -57.87 87.41, -1.46 na-out-out SNCaoo out-out ActLoopNT-out 8.36 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.01, -48.69 APE9-dihe-out -50.14, -31.16 APE8-dihe-out -81.83, -2.56 APE8-rot-na 292.76 APE67-dihe-out -91.8, 2.07 -66.27, 133.13 APE12-dist-na 10.153 APE11-dist-na 12.31 APE10-dist-na 16.62 APE9-dist-out 11.977 None None None XRAY 2.15 0.217 0.268 A 335 261 33 0 0 0 [[589, 868], [897, 1171]] 2.0 3zon Homo sapiens TYR_TYK2-1_HUMAN TYR 6.5e-60 208.7 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZRA P29597 578 867 1187.0 LAJ:901 Type1 Pseudo DFGin 7.777 12.781 None -69.45, 168.07 -65.99, 154.27 -73.6, -4.41 23.84, 151.16 77.17, -140.45 in-na in 9.435 Saltbr-na 999.0 HRD-in -82.75, -62.0 89.42, -4.52 na-out-out SNCaoo out-out ActLoopNT-out 8.095 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.36, -40.74 APE9-dihe-out -63.5, -26.3 APE8-dihe-out -83.27, -1.28 APE8-rot-na 205.99 APE67-dihe-out -86.49, -0.68 -74.39, 134.15 APE12-dist-na 9.712 APE11-dist-na 12.195 APE10-dist-na 16.359 APE9-dist-out 11.553 None None None XRAY 2.56 0.19 0.229 A 317 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZRB P29597 580 868 1187.0 LAJ:901 Type1 Pseudo DFGin 7.794 12.735 None -69.51, 167.49 -66.18, 155.4 -74.3, -4.56 23.99, 151.21 77.6, -139.58 in-na in 9.371 Saltbr-na 999.0 HRD-in -85.74, -61.72 89.77, -6.44 na-out-out SNCaoo out-out ActLoopNT-out 8.164 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.72, -41.32 APE9-dihe-out -63.03, -22.95 APE8-dihe-out -84.92, -4.81 APE8-rot-na 227.24 APE67-dihe-out -86.54, 0.37 -71.84, 134.55 APE12-dist-na 9.706 APE11-dist-na 12.223 APE10-dist-na 16.378 APE9-dist-out 11.55 None None None XRAY 2.56 0.19 0.229 B 317 259 30 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzr Homo sapiens TYR_TYK2-1_HUMAN TYR 3e-60 209.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4WOVA P29597 580 869 1187.0 3SM:901 Type1 Pseudo DFGin 7.414 12.612 None -81.79, 172.74 -64.96, 152.2 -79.14, 3.8 29.41, 144.45 64.39, -148.74 in-na in 9.434 Saltbr-na 999.0 HRD-in -91.37, -57.71 81.66, 1.38 na-out-out SNCaoo out-out ActLoopNT-out 8.472 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.89, -40.33 APE9-dihe-out -59.96, -25.88 APE8-dihe-out -82.28, -6.26 APE8-rot-na 203.31 APE67-dihe-out -93.77, 1.64 -65.5, 131.41 APE12-dist-na 9.865 APE11-dist-na 12.155 APE10-dist-na 16.373 APE9-dist-out 11.62 None None None XRAY 1.8 0.193 0.214 A 317 258 32 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 4WOVB P29597 580 867 1187.0 3SM:901 Type1 Pseudo DFGin 7.375 12.564 None -82.96, 174.29 -64.97, 150.22 -78.54, 4.38 29.82, 144.02 64.16, -150.45 in-na in 9.386 Saltbr-na 999.0 HRD-in -91.0, -57.11 81.71, 1.86 na-out-out SNCaoo out-out ActLoopNT-out 8.54 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.69, -39.07 APE9-dihe-out -62.22, -22.21 APE8-dihe-out -86.45, -3.31 APE8-rot-na 190.55 APE67-dihe-out -96.7, 6.38 -71.04, 134.12 APE12-dist-na 9.828 APE11-dist-na 12.112 APE10-dist-na 16.313 APE9-dist-out 11.656 None None None XRAY 1.8 0.193 0.214 B 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 4wov Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NSLA P29597 581 866 1187.0 KZJ:901 Type1 Pseudo DFGin 7.447 12.627 None -65.67, 163.1 -59.9, 147.3 -72.43, 0.95 25.4, 149.24 71.0, -150.31 in-na in 9.45 Saltbr-na 999.0 HRD-in -79.19, -61.15 86.61, -0.76 na-out-out SNCaoo out-out ActLoopNT-out 8.317 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.34, -39.28 APE9-dihe-out -63.02, -22.39 APE8-dihe-out -82.22, -10.35 APE8-rot-na 292.93 APE67-dihe-out -91.53, -2.04 -67.32, 133.05 APE12-dist-na 9.722 APE11-dist-na 12.197 APE10-dist-na 16.413 APE9-dist-out 11.7 None None None XRAY 2.15 0.203 0.213 A 317 251 37 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NSLB P29597 581 867 1187.0 KZJ:901 Type1 Pseudo DFGin 7.466 12.543 None -65.53, 162.68 -58.2, 146.74 -72.38, 1.37 25.74, 148.82 71.06, -152.3 in-na in 9.423 Saltbr-na 999.0 HRD-in -80.39, -61.97 87.32, -2.61 na-out-out SNCaoo out-out ActLoopNT-out 8.241 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -66.57, -38.38 APE9-dihe-out -63.64, -23.52 APE8-dihe-out -84.88, -4.11 APE8-rot-na 200.51 APE67-dihe-out -91.36, -1.36 -71.83, 133.14 APE12-dist-na 9.667 APE11-dist-na 12.177 APE10-dist-na 16.391 APE9-dist-out 11.568 None None None XRAY 2.15 0.203 0.213 B 317 248 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nsl Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZEA P29597 581 863 1187.0 L8Y:901 Type1 Pseudo DFGin 7.517 12.327 None -67.15, 165.53 -62.27, 154.27 -78.2, -0.61 28.22, 144.21 70.11, -150.04 in-na in 9.308 Saltbr-na 999.0 HRD-in -90.68, -61.1 81.57, 5.39 na-out-out SNCaoo out-out ActLoopNT-out 8.127 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.25, -36.4 APE9-dihe-out -64.18, -24.4 APE8-dihe-out -85.3, -4.22 APE8-rot-na 196.84 APE67-dihe-out -93.12, 7.25 -69.65, 135.35 APE12-dist-na 9.814 APE11-dist-na 12.241 APE10-dist-na 16.458 APE9-dist-out 11.439 None None None XRAY 1.96 0.197 0.227 A 317 250 38 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZEB P29597 580 867 1187.0 L8Y:901 Type1 Pseudo DFGin 7.51 12.331 None -67.31, 165.25 -60.76, 154.35 -79.17, -0.55 28.55, 143.7 69.96, -145.72 in-na in 9.336 Saltbr-na 999.0 HRD-in -88.53, -60.87 81.08, 6.03 na-out-out SNCaoo out-out ActLoopNT-out 8.073 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.94, -35.62 APE9-dihe-out -64.8, -24.24 APE8-dihe-out -85.49, -3.91 APE8-rot-na 196.79 APE67-dihe-out -92.3, 6.8 -70.0, 135.83 APE12-dist-na 9.732 APE11-dist-na 12.151 APE10-dist-na 16.38 APE9-dist-out 11.416 None None None XRAY 1.96 0.197 0.227 B 317 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 6nze Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZFA P29597 580 865 1187.0 L91:901 Type1 Pseudo DFGin 7.6 12.671 None -71.29, 168.26 -64.87, 155.03 -75.86, -3.47 25.03, 153.09 77.38, -149.91 in-na in 9.401 Saltbr-na 999.0 HRD-in -80.34, -62.67 82.96, 5.24 na-out-out SNCaoo out-out ActLoopNT-out 8.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.48, -39.01 APE9-dihe-out -62.83, -25.44 APE8-dihe-out -82.23, -7.85 APE8-rot-na 215.68 APE67-dihe-out -92.43, 5.04 -68.27, 132.64 APE12-dist-na 9.808 APE11-dist-na 12.262 APE10-dist-na 16.517 APE9-dist-out 11.623 None None None XRAY 2.39 0.205 0.231 A 317 247 42 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZFB P29597 580 867 1187.0 L91:901 Type1 Pseudo DFGin 7.67 12.598 None -70.84, 168.4 -64.97, 153.82 -75.67, -2.7 25.33, 152.34 77.04, -149.81 in-na in 9.372 Saltbr-na 999.0 HRD-in -81.43, -61.17 83.19, 3.8 na-out-out SNCaoo out-out ActLoopNT-out 8.112 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.59, -38.89 APE9-dihe-out -62.81, -25.28 APE8-dihe-out -84.37, -2.23 APE8-rot-na 213.59 APE67-dihe-out -91.99, 5.73 -72.88, 133.85 APE12-dist-na 9.752 APE11-dist-na 12.229 APE10-dist-na 16.478 APE9-dist-out 11.555 None None None XRAY 2.39 0.205 0.231 B 317 248 41 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzf Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZHA P29597 581 866 1187.0 L9A:4000 Type1 Pseudo DFGin 7.406 12.772 None -62.74, 170.7 -72.48, 150.15 -70.83, -2.83 23.35, 152.01 73.55, -152.26 in-na in 9.497 Saltbr-na 999.0 HRD-in -83.24, -60.86 86.7, -4.43 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.05, -35.12 APE9-dihe-out -65.62, -29.8 APE8-dihe-out -77.88, -5.55 APE8-rot-na 294.99 APE67-dihe-out -89.76, 4.67 -72.08, 133.72 APE12-dist-na 9.775 APE11-dist-na 12.229 APE10-dist-na 16.47 APE9-dist-out 11.317 None None None XRAY 2.73 0.193 0.215 A 317 249 39 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZHB P29597 580 867 1187.0 L9A:4000 Type1 Pseudo DFGin 7.436 12.599 None -60.73, 169.6 -71.23, 150.14 -70.46, -1.47 23.31, 151.91 71.77, -152.11 in-na in 9.376 Saltbr-na 999.0 HRD-in -83.11, -60.28 86.79, -5.89 na-out-out SNCaoo out-out ActLoopNT-out 8.308 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.38, -35.33 APE9-dihe-out -65.44, -29.63 APE8-dihe-out -78.49, -5.17 APE8-rot-na 295.66 APE67-dihe-out -89.42, 4.66 -71.76, 134.2 APE12-dist-na 9.735 APE11-dist-na 12.216 APE10-dist-na 16.437 APE9-dist-out 11.269 None None None XRAY 2.73 0.193 0.215 B 317 249 40 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzh Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZPA P29597 580 869 1187.0 LB7:901 Type1 Pseudo DFGin 7.454 12.358 None -74.98, 168.42 -62.51, 146.95 -73.8, -0.03 29.8, 144.9 77.36, -162.45 in-na in 9.216 Saltbr-na 999.0 HRD-in -77.18, -62.62 87.16, 3.67 na-out-out SNCaoo out-out ActLoopNT-out 8.307 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.98, -44.81 APE9-dihe-out -54.69, -25.84 APE8-dihe-out -83.74, 2.24 APE8-rot-na 279.61 APE67-dihe-out -91.79, -3.26 -74.14, 129.81 APE12-dist-na 9.758 APE11-dist-na 11.986 APE10-dist-na 16.154 APE9-dist-out 11.555 None None None XRAY 2.35 0.191 0.238 A 317 259 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZPB P29597 580 868 1187.0 LB7:901 Type1 Pseudo DFGin 7.457 12.377 None -74.39, 168.01 -61.52, 147.56 -74.66, 0.45 29.5, 145.4 75.25, -161.58 in-na in 9.288 Saltbr-na 999.0 HRD-in -77.4, -62.3 87.31, 3.57 na-out-out SNCaoo out-out ActLoopNT-out 8.247 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -56.49, -45.45 APE9-dihe-out -54.3, -24.89 APE8-dihe-out -83.35, -4.08 APE8-rot-na 280.62 APE67-dihe-out -91.28, -1.02 -71.12, 130.29 APE12-dist-na 9.773 APE11-dist-na 12.02 APE10-dist-na 16.21 APE9-dist-out 11.556 None None None XRAY 2.35 0.191 0.238 B 317 260 29 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzp Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZQA P29597 580 867 1187.0 LB4:4000 Type1 Pseudo DFGin 7.504 12.4 None -72.22, 171.6 -66.25, 148.31 -74.94, 3.34 30.76, 143.31 66.4, -168.53 in-na in 9.039 Saltbr-na 999.0 HRD-in -79.47, -65.7 83.13, 11.6 na-out-out SNCaoo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.2, -35.07 APE9-dihe-out -63.1, -22.48 APE8-dihe-out -87.78, -5.31 APE8-rot-na 268.32 APE67-dihe-out -91.66, 0.19 -69.75, 131.87 APE12-dist-na 9.881 APE11-dist-na 12.092 APE10-dist-na 16.368 APE9-dist-out 11.72 None None None XRAY 2.11 0.199 0.237 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 6NZQB P29597 580 868 1187.0 LB4:4000 Type1 Pseudo DFGin 7.552 12.37 None -70.99, 170.41 -64.59, 148.83 -75.35, 4.18 30.96, 143.54 65.3, -166.93 in-na in 8.958 Saltbr-na 999.0 HRD-in -80.49, -65.88 83.34, 10.69 na-out-out SNCaoo out-out ActLoopNT-out 8.442 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.78, -35.63 APE9-dihe-out -62.43, -22.89 APE8-dihe-out -87.56, -5.29 APE8-rot-na 268.51 APE67-dihe-out -92.56, 0.73 -69.67, 131.53 APE12-dist-na 9.911 APE11-dist-na 12.088 APE10-dist-na 16.439 APE9-dist-out 11.694 None None None XRAY 2.11 0.199 0.237 B 317 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 6nzq Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7K7OA P29597 580 867 1187.0 VZJ:901 Type1 Pseudo DFGin 7.366 12.565 None -66.43, 170.03 -67.36, 143.81 -70.91, 1.79 25.53, 145.85 78.47, -152.75 in-na in 9.266 Saltbr-na 999.0 HRD-in -75.49, -66.33 85.17, 12.8 na-out-out SNCaoo out-out ActLoopNT-out 8.181 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.32, -40.35 APE9-dihe-out -58.15, -35.87 APE8-dihe-out -71.09, -6.29 APE8-rot-na 289.01 APE67-dihe-out -84.78, -2.19 -73.46, 133.77 APE12-dist-na 9.765 APE11-dist-na 12.088 APE10-dist-na 16.266 APE9-dist-out 11.763 None None None XRAY 2.82 0.181 0.252 A 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7K7OB P29597 580 868 1187.0 VZJ:901 Type1 Pseudo DFGin 7.723 12.247 None -71.51, -175.68 -81.24, 151.01 -79.84, 4.8 35.04, 138.85 72.06, -152.96 in-na in 9.264 Saltbr-na 999.0 HRD-in -101.81, -60.3 88.52, -5.44 na-out-out SNCaoo out-out ActLoopNT-out 8.923 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.95, -43.16 APE9-dihe-out -55.55, -22.53 APE8-dihe-out -85.45, 0.22 APE8-rot-na 226.83 APE67-dihe-out -83.49, -4.03 -76.46, 136.55 APE12-dist-na 9.628 APE11-dist-na 12.199 APE10-dist-na 16.268 APE9-dist-out 11.283 None None None XRAY 2.82 0.181 0.252 B 317 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7o Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7K7QA P29597 580 867 1187.0 VZG:901 Type1 Pseudo DFGin 7.543 12.533 None -69.2, 167.5 -63.98, 154.51 -77.3, 7.34 29.56, 146.11 63.89, -146.65 in-na in 9.281 Saltbr-na 999.0 HRD-in -79.96, -60.41 88.18, -6.56 na-out-out SNCaoo out-out ActLoopNT-out 8.398 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.8, -37.69 APE9-dihe-out -61.19, -23.02 APE8-dihe-out -86.96, -5.2 APE8-rot-na 283.59 APE67-dihe-out -89.93, 5.32 -68.44, 135.46 APE12-dist-na 9.824 APE11-dist-na 12.119 APE10-dist-na 16.488 APE9-dist-out 11.802 None None None XRAY 2.27 0.191 0.215 A 317 256 33 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 7K7QB P29597 580 868 1187.0 VZG:901 Type1 Pseudo DFGin 7.528 12.484 None -69.63, 166.47 -62.41, 154.32 -76.74, 6.87 29.05, 146.64 63.93, -146.22 in-na in 9.264 Saltbr-na 999.0 HRD-in -80.84, -60.47 88.54, -6.14 na-out-out SNCaoo out-out ActLoopNT-out 8.387 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.52, -36.89 APE9-dihe-out -61.37, -23.14 APE8-dihe-out -89.62, -0.64 APE8-rot-na 285.2 APE67-dihe-out -89.84, 4.92 -69.09, 135.18 APE12-dist-na 9.785 APE11-dist-na 12.127 APE10-dist-na 16.459 APE9-dist-out 11.701 None None None XRAY 2.27 0.191 0.215 B 317 251 38 0 0 0 [[589, 868], [897, 1171]] 2.0 7k7q Homo sapiens TYR_TYK2-1_HUMAN TYR 5.4e-60 208.9 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8TB5A P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.575 12.828 None -72.9, 166.16 -62.82, 156.7 -75.2, -1.8 19.44, 155.05 65.85, -157.21 in-na in 9.628 Saltbr-na 999.0 HRD-in -77.18, -55.68 90.86, -17.89 na-out-out SNCaoo out-out ActLoopNT-out 8.033 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.91, -37.05 APE9-dihe-out -64.82, -24.45 APE8-dihe-out -87.22, -2.73 APE8-rot-na 294.55 APE67-dihe-out -99.67, 13.88 -62.74, 133.89 APE12-dist-na 9.966 APE11-dist-na 12.452 APE10-dist-na 16.637 APE9-dist-out 11.819 None None None XRAY 2.32 0.187 0.243 A 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8TB5B P29597 580 868 1187.0 ZOQ:902 Type1 Pseudo DFGin 7.354 12.83 None -69.46, 162.15 -62.48, 155.25 -75.42, -2.04 28.22, 143.07 66.45, -159.8 in-na in 9.655 Saltbr-na 999.0 HRD-in -80.42, -58.38 87.54, 2.75 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.71, -36.16 APE9-dihe-out -65.57, -18.78 APE8-dihe-out -89.43, 3.6 APE8-rot-na 301.67 APE67-dihe-out -95.11, 8.54 -67.3, 136.04 APE12-dist-na 10.02 APE11-dist-na 12.281 APE10-dist-na 16.5 APE9-dist-out 11.726 None None None XRAY 2.32 0.187 0.243 B 326 257 32 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb5 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8TB6A P29597 572 869 1187.0 ZOI:901 Type1 Pseudo DFGin 7.519 12.918 None -70.48, 163.05 -64.31, 156.7 -77.96, 2.63 25.15, 152.72 70.88, -150.51 in-na in 9.757 Saltbr-na 999.0 HRD-in -88.04, -58.25 80.3, 7.16 na-out-out SNCaoo out-out ActLoopNT-out 8.005 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.83, -38.13 APE9-dihe-out -58.13, -23.83 APE8-dihe-out -87.03, -4.8 APE8-rot-na 225.26 APE67-dihe-out -95.58, 10.52 -67.22, 136.28 APE12-dist-na 9.67 APE11-dist-na 12.214 APE10-dist-na 16.343 APE9-dist-out 11.339 None None None XRAY 1.96 0.195 0.236 A 326 263 33 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 8TB6B P29597 580 867 1187.0 ZOI:901 Type1 Pseudo DFGin 7.575 12.834 None -75.19, 161.88 -63.62, 154.56 -77.31, 0.0 28.4, 144.85 69.85, -142.97 in-na in 9.746 Saltbr-na 999.0 HRD-in -86.92, -60.13 92.81, -6.33 na-out-out SNCaoo out-out ActLoopNT-out 8.229 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -58.54, -39.0 APE9-dihe-out -57.31, -25.9 APE8-dihe-out -87.7, -3.61 APE8-rot-na 309.71 APE67-dihe-out -99.75, 10.76 -63.68, 135.57 APE12-dist-na 9.794 APE11-dist-na 12.116 APE10-dist-na 16.334 APE9-dist-out 11.431 None None None XRAY 1.96 0.195 0.236 B 326 254 35 0 0 0 [[589, 868], [897, 1171]] 2.0 8tb6 Homo sapiens TYR_TYK2-1_HUMAN TYR 5.9e-60 208.8 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5C01A P29597 580 868 1187.0 UNL:901 Type1 Pseudo DFGin 7.494 12.953 None -78.77, 168.17 -59.3, 158.84 -78.02, -0.56 29.95, 141.01 70.43, -143.96 in-na in 9.86 Saltbr-na 999.0 HRD-in -88.89, -66.71 89.22, 5.88 na-out-out SNCaoo out-out ActLoopNT-out 8.02 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.06, -43.56 APE9-dihe-out -60.5, -24.62 APE8-dihe-out -84.02, 0.04 APE8-rot-na 309.1 APE67-dihe-out -102.6, 18.85 -65.89, 133.72 APE12-dist-na 10.035 APE11-dist-na 12.558 APE10-dist-na 16.715 APE9-dist-out 11.348 None None None XRAY 2.15 0.197 0.24 A 342 258 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYK2_HUMAN 5C01B P29597 579 869 1187.0 UNL:901 Type1 Pseudo DFGin 7.503 12.99 None -83.69, 167.93 -60.38, 156.97 -77.3, 1.6 26.16, 146.38 64.95, -141.34 in-na in 9.846 Saltbr-na 999.0 HRD-in -91.02, -62.48 85.42, 13.36 na-out-out SNCaoo out-out ActLoopNT-out 8.054 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.57, -43.79 APE9-dihe-out -56.12, -28.45 APE8-dihe-out -84.03, 3.14 APE8-rot-na 209.42 APE67-dihe-out -101.1, 17.13 -74.09, 134.94 APE12-dist-na 9.989 APE11-dist-na 12.592 APE10-dist-na 16.738 APE9-dist-out 11.636 None None None XRAY 2.15 0.197 0.24 B 342 260 31 0 0 0 [[589, 868], [897, 1171]] 2.0 5c01 Homo sapiens TYR_TYK2-1_HUMAN TYR 7e-60 208.6 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

TYR_TYK2-1 (Non-receptor tyrosine-protein kinase TYK2)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name