CMGC_SRPK1 (SRSF protein kinase 1)

Total number of chains: 17
Active chains: 9
Family: CMGC
Uniprot: SRPK1_HUMAN
Kinase Domain Residues: 80 - 653
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 94.1% AF-Q96SB4-K1A
DFGin ABAminus 1 5.9% 5MY8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
1WBPA 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.093 14.484 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.616 Saltbr-in 3.534 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.421 APE11-dist-in 10.401 APE10-dist-in 7.455 APE9-dist-in 2.973 None None None XRAY 2.4 0.228 0.247 A 397 350 22 0 0 0 [[80, 653]] 1.0 1wbp CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
AF-Q96SB4-K1A 72 655 655.0 No_ligand No_ligand Active DFGin 5.973 13.522 BLAminus -137.47, 170.76 58.1, 67.72 -72.16, 18.75 278.92, 68.58 -65.71, -24.32 in-in in 8.949 Saltbr-in 2.685 HRD-in -75.3, -32.74 59.66, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.16, 170.06 APE9-dihe-na 63.26, 134.21 APE8-dihe-in -59.55, 141.9 APE8-rot-in 297.36 APE67-dihe-in -71.04, -14.77 -42.92, -52.14 APE12-dist-in 12.691 APE11-dist-in 10.547 APE10-dist-in 7.556 APE9-dist-in 3.092 None None None AF2 -1.0 1.0 1.0 A 584 584 0 0 0 0 [[80, 653]] 1.0 AF-Q96SB4-K1 CMGC_SRPK1_HUMAN CMGC 1.3e-138 467.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
AF-Q96SB4-K3A 72 655 655.0 No_ligand No_ligand Active DFGin 5.91 13.541 BLAminus -132.1, 177.62 57.12, 71.14 -79.34, 17.2 282.1, 75.67 -63.65, -27.59 in-in in 8.971 Saltbr-in 2.704 HRD-in -75.81, -31.81 67.91, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.76, 171.43 APE9-dihe-na 61.31, 131.01 APE8-dihe-in -56.69, 141.29 APE8-rot-in 299.79 APE67-dihe-in -68.19, -14.94 -50.79, -44.23 APE12-dist-in 12.361 APE11-dist-in 10.403 APE10-dist-in 7.535 APE9-dist-in 3.232 None None None AF2 -1.0 1.0 1.0 A 584 584 0 0 0 0 [[80, 653]] 1.0 AF-Q96SB4-K3 CMGC_SRPK1_HUMAN CMGC 1.3e-138 467.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
7PQSA 66 655 655.0 80H:60601 Type1 Active DFGin 6.006 13.872 BLAminus -127.8, -178.15 48.65, 81.95 -87.95, 18.8 267.02, 74.25 -68.56, -13.7 in-in in 9.456 Saltbr-in 2.647 HRD-in -64.0, -47.52 70.22, -0.34 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.91, 162.84 APE9-dihe-na 78.77, 142.25 APE8-dihe-in -66.81, 145.98 APE8-rot-in 300.52 APE67-dihe-in -63.88, -18.78 -43.23, -59.52 APE12-dist-in 12.718 APE11-dist-in 10.461 APE10-dist-in 7.497 APE9-dist-in 3.023 None None None XRAY 2.2 0.201 0.236 A 383 351 22 0 0 0 [[80, 653]] 1.0 7pqs CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
7PQSB 66 655 655.0 80H:60503 Type1 Active DFGin 6.009 13.857 BLAminus -128.6, -177.14 47.47, 80.86 -86.65, 18.25 267.95, 73.5 -68.18, -14.49 in-in in 9.452 Saltbr-in 2.644 HRD-in -63.44, -47.45 70.47, 0.57 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.34, 161.25 APE9-dihe-na 80.67, 141.76 APE8-dihe-in -65.64, 144.79 APE8-rot-in 300.57 APE67-dihe-in -62.69, -19.34 -42.72, -60.07 APE12-dist-in 12.754 APE11-dist-in 10.404 APE10-dist-in 7.492 APE9-dist-in 3.038 None None None XRAY 2.2 0.201 0.236 B 383 351 22 0 0 0 [[80, 653]] 1.0 7pqs CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
7ZKSA 67 655 655.0 IXQ:701 Type1 Active DFGin 5.922 13.832 BLAminus -124.07, 176.36 61.15, 67.29 -81.69, 19.05 282.89, 92.77 -70.66, -18.4 in-in in 9.663 Saltbr-in 2.732 HRD-in -60.32, -44.65 68.64, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.52, 164.81 APE9-dihe-na 71.13, 145.06 APE8-dihe-in -73.4, 143.68 APE8-rot-in 291.25 APE67-dihe-in -76.74, -22.26 -39.85, -46.81 APE12-dist-in 12.629 APE11-dist-in 10.535 APE10-dist-in 7.481 APE9-dist-in 3.099 None None None XRAY 2.28 0.245 0.29 A 387 348 22 0 0 0 [[80, 653]] 1.0 7zks CMGC_SRPK1_HUMAN CMGC 1.8e-139 470.0 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
4WUAA 69 655 655.0 3UL:701 Type1 Active DFGin 6.102 14.135 BLAminus -127.41, -171.15 54.73, 65.78 -81.43, 11.78 270.61, 76.74 -66.88, -14.14 in-in in 9.476 Saltbr-in 3.448 HRD-in -65.66, -44.4 71.86, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.69, 169.15 APE9-dihe-na 71.35, 146.29 APE8-dihe-in -69.47, 139.21 APE8-rot-in 296.34 APE67-dihe-in -67.85, -19.35 -35.93, -58.81 APE12-dist-in 12.772 APE11-dist-in 10.523 APE10-dist-in 7.58 APE9-dist-in 3.048 None None None XRAY 2.0 0.199 0.236 A 401 344 25 0 0 0 [[80, 653]] 1.0 4wua CMGC_SRPK1_HUMAN CMGC 2e-139 469.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
5XV7A 67 655 655.0 EMH:705 Type1 Active DFGin 5.995 13.966 BLAminus -124.46, -177.25 65.64, 63.97 -83.12, 15.14 272.88, 70.82 -65.18, -13.48 in-in in 9.59 Saltbr-in 2.926 HRD-in -71.11, -43.72 78.74, -4.15 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.29, 164.0 APE9-dihe-na 73.39, 140.72 APE8-dihe-in -72.68, 146.09 APE8-rot-in 298.82 APE67-dihe-in -70.15, -17.54 -41.94, -55.9 APE12-dist-in 12.772 APE11-dist-in 10.486 APE10-dist-in 7.606 APE9-dist-in 3.05 None None None XRAY 2.32 0.213 0.238 A 372 350 22 0 0 0 [[80, 653]] 1.0 5xv7 CMGC_SRPK1_HUMAN CMGC 1.1e-138 467.4 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
5MXXA 56 655 655.0 W4A:701 Type1 Active DFGin 5.977 14.189 BLAminus -117.74, -175.37 55.98, 72.09 -86.99, 11.79 273.83, 86.12 -60.63, -21.63 in-in in 9.209 Saltbr-in 2.975 HRD-in -71.08, -46.72 78.08, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.86, 168.59 APE9-dihe-na 76.28, 126.73 APE8-dihe-in -50.41, 144.32 APE8-rot-in 293.68 APE67-dihe-in -70.94, -15.39 -51.89, -47.56 APE12-dist-in 12.738 APE11-dist-in 10.148 APE10-dist-in 7.396 APE9-dist-in 3.163 None None None XRAY 1.75 0.175 0.205 A 399 361 22 0 0 0 [[80, 653]] 1.0 5mxx CMGC_SRPK1_HUMAN CMGC 9.4e-139 467.6 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
5MY8A 64 655 655.0 RXZ:724 Type1 Inactive DFGin 5.962 13.842 ABAminus -122.04, -29.62 -98.53, 98.95 -96.5, 16.27 273.03, 55.03 -66.84, -13.73 in-in in 9.198 Saltbr-in 2.945 HRD-in -70.3, -48.47 74.15, -9.5 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.15, 161.89 APE9-dihe-na 79.84, 140.15 APE8-dihe-in -69.93, 140.53 APE8-rot-in 296.54 APE67-dihe-in -70.56, -18.82 -39.68, -56.02 APE12-dist-in 12.76 APE11-dist-in 10.597 APE10-dist-in 7.655 APE9-dist-in 3.147 None None None XRAY 1.7 0.166 0.2 A 383 355 19 0 0 0 [[80, 653]] 1.0 5my8 CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
3BEGA 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.846 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.999 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.995 APE11-dist-in 10.441 APE10-dist-in 7.835 APE9-dist-in 3.062 None None None XRAY 2.9 0.24 0.298 A 381 348 21 0 0 0 [[80, 653]] 1.0 3beg CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
1WAKA 63 655 655.0 No_ligand No_ligand Inactive DFGin 6.205 14.675 BLAminus -123.0, -174.54 53.6, 68.83 -86.08, 19.05 272.45, 68.37 -61.63, -18.59 in-out in 9.935 Saltbr-out 4.386 HRD-in -70.54, -43.03 69.99, -4.62 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 167.9 APE9-dihe-na 70.72, 141.75 APE8-dihe-in -70.88, 141.01 APE8-rot-in 287.67 APE67-dihe-in -64.98, -18.19 -31.46, -62.63 APE12-dist-in 12.722 APE11-dist-in 10.369 APE10-dist-in 7.526 APE9-dist-in 3.114 None None None XRAY 1.73 0.198 0.218 A 397 353 21 0 0 0 [[80, 653]] 1.0 1wak CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
7DD1A 67 655 655.0 No_ligand No_ligand Inactive DFGin 6.087 14.461 BLAminus -126.87, 176.64 64.43, 66.57 -85.53, 15.97 273.29, 78.5 -65.27, -18.19 in-out in 9.846 Saltbr-out 4.308 HRD-in -64.64, -50.12 78.41, -7.9 out-in-in SNCoii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.14, 163.04 APE9-dihe-na 78.77, 142.36 APE8-dihe-in -68.04, 142.24 APE8-rot-in 297.31 APE67-dihe-in -67.62, -16.97 -42.36, -56.41 APE12-dist-in 12.774 APE11-dist-in 10.458 APE10-dist-in 7.547 APE9-dist-in 3.027 None None None XRAY 2.05 0.182 0.221 A 398 351 20 0 0 0 [[80, 653]] 1.0 7dd1 CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
6FADA 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.22 15.136 BLAminus -122.93, 179.12 57.38, 61.42 -78.03, 19.0 277.69, 78.02 -68.08, -18.77 in-out in 9.929 Saltbr-out 5.699 HRD-in -65.55, -50.38 76.6, 9.52 out-in-out SNCoio in-out ActLoopNT-in 3.046 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.2, 171.46 APE9-dihe-na 71.78, 143.02 APE8-dihe-in -86.05, 154.67 APE8-rot-out 81.2 APE67-dihe-in -62.54, -19.42 -41.68, -58.38 APE12-dist-in 12.82 APE11-dist-in 10.988 APE10-dist-in 7.672 APE9-dist-in 3.138 None None None XRAY 2.801 0.201 0.257 A 618 356 245 0 0 0 [[80, 653]] 1.0 6fad CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
6FADB 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.232 14.986 BLAminus -113.6, 174.2 60.21, 87.3 -102.47, 28.18 286.78, 61.47 -69.13, -15.83 in-out in 9.748 Saltbr-out 4.624 HRD-in -75.61, -45.96 73.19, 8.23 out-in-out SNCoio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.25, 164.85 APE9-dihe-na 73.22, 157.16 APE8-dihe-in -99.01, 141.77 APE8-rot-out 60.06 APE67-dihe-in -66.35, -13.73 -20.25, -68.69 APE12-dist-in 12.617 APE11-dist-in 10.907 APE10-dist-in 7.75 APE9-dist-in 3.18 None None None XRAY 2.801 0.201 0.257 B 618 356 245 0 0 0 [[80, 653]] 1.0 6fad CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
6FADC 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.517 15.295 BLAminus -123.52, -178.15 55.08, 85.74 -104.19, 20.56 276.3, 81.28 -67.88, -18.36 in-out in 9.967 Saltbr-out 5.558 HRD-in -74.58, -44.68 71.07, 8.29 out-in-in SNCoii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.77, 164.16 APE9-dihe-na 77.72, 151.02 APE8-dihe-in -86.55, 133.38 APE8-rot-in 273.9 APE67-dihe-in -62.07, -14.6 -22.9, -73.33 APE12-dist-in 12.691 APE11-dist-in 10.719 APE10-dist-in 7.639 APE9-dist-in 3.236 None None None XRAY 2.801 0.201 0.257 C 618 359 242 0 0 0 [[80, 653]] 1.0 6fad CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
6FADD 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.377 15.33 BLAminus -119.7, -178.47 48.47, 81.81 -91.0, 13.61 274.63, 34.06 -64.49, -20.18 out-out out 10.194 Saltbr-out 5.179 HRD-in -73.88, -47.0 76.16, 9.55 out-in-in SNCoii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.69, 159.48 APE9-dihe-na 80.31, 146.18 APE8-dihe-in -75.32, 143.12 APE8-rot-in 297.81 APE67-dihe-in -63.2, -18.62 -40.87, -60.1 APE12-dist-in 12.786 APE11-dist-in 10.624 APE10-dist-in 7.756 APE9-dist-in 3.164 None None None XRAY 2.801 0.201 0.257 D 618 356 245 0 0 0 [[80, 653]] 1.0 6fad CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1

CMGC_SRPK1 (SRSF protein kinase 1)

Total number of chains: 17
Active chains: 9
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 16 94.1% AF-Q96SB4-K1A
DFGin ABAminus 1 5.9% 5MY8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SRPK1_HUMAN 1WBPA Q96SB4 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.093 14.484 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.616 Saltbr-in 3.534 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.421 APE11-dist-in 10.401 APE10-dist-in 7.455 APE9-dist-in 2.973 None None None XRAY 2.4 0.228 0.247 A 397 350 22 0 0 0 [[80, 653]] 1.0 1wbp Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN AF-Q96SB4-K1A Q96SB4 72 655 655.0 No_ligand No_ligand Active DFGin 5.973 13.522 BLAminus -137.47, 170.76 58.1, 67.72 -72.16, 18.75 278.92, 68.58 -65.71, -24.32 in-in in 8.949 Saltbr-in 2.685 HRD-in -75.3, -32.74 59.66, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.16, 170.06 APE9-dihe-na 63.26, 134.21 APE8-dihe-in -59.55, 141.9 APE8-rot-in 297.36 APE67-dihe-in -71.04, -14.77 -42.92, -52.14 APE12-dist-in 12.691 APE11-dist-in 10.547 APE10-dist-in 7.556 APE9-dist-in 3.092 None None None AF2 -1.0 1.0 1.0 A 584 584 0 0 0 0 [[80, 653]] 1.0 AF-Q96SB4-K1 Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.3e-138 467.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN AF-Q96SB4-K3A Q96SB4 72 655 655.0 No_ligand No_ligand Active DFGin 5.91 13.541 BLAminus -132.1, 177.62 57.12, 71.14 -79.34, 17.2 282.1, 75.67 -63.65, -27.59 in-in in 8.971 Saltbr-in 2.704 HRD-in -75.81, -31.81 67.91, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.76, 171.43 APE9-dihe-na 61.31, 131.01 APE8-dihe-in -56.69, 141.29 APE8-rot-in 299.79 APE67-dihe-in -68.19, -14.94 -50.79, -44.23 APE12-dist-in 12.361 APE11-dist-in 10.403 APE10-dist-in 7.535 APE9-dist-in 3.232 None None None AF2 -1.0 1.0 1.0 A 584 584 0 0 0 0 [[80, 653]] 1.0 AF-Q96SB4-K3 Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.3e-138 467.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 7PQSA Q96SB4 66 655 655.0 80H:60601 Type1 Active DFGin 6.006 13.872 BLAminus -127.8, -178.15 48.65, 81.95 -87.95, 18.8 267.02, 74.25 -68.56, -13.7 in-in in 9.456 Saltbr-in 2.647 HRD-in -64.0, -47.52 70.22, -0.34 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.91, 162.84 APE9-dihe-na 78.77, 142.25 APE8-dihe-in -66.81, 145.98 APE8-rot-in 300.52 APE67-dihe-in -63.88, -18.78 -43.23, -59.52 APE12-dist-in 12.718 APE11-dist-in 10.461 APE10-dist-in 7.497 APE9-dist-in 3.023 None None None XRAY 2.2 0.201 0.236 A 383 351 22 0 0 0 [[80, 653]] 1.0 7pqs Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 7PQSB Q96SB4 66 655 655.0 80H:60503 Type1 Active DFGin 6.009 13.857 BLAminus -128.6, -177.14 47.47, 80.86 -86.65, 18.25 267.95, 73.5 -68.18, -14.49 in-in in 9.452 Saltbr-in 2.644 HRD-in -63.44, -47.45 70.47, 0.57 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.34, 161.25 APE9-dihe-na 80.67, 141.76 APE8-dihe-in -65.64, 144.79 APE8-rot-in 300.57 APE67-dihe-in -62.69, -19.34 -42.72, -60.07 APE12-dist-in 12.754 APE11-dist-in 10.404 APE10-dist-in 7.492 APE9-dist-in 3.038 None None None XRAY 2.2 0.201 0.236 B 383 351 22 0 0 0 [[80, 653]] 1.0 7pqs Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 7ZKSA Q96SB4 67 655 655.0 IXQ:701 Type1 Active DFGin 5.922 13.832 BLAminus -124.07, 176.36 61.15, 67.29 -81.69, 19.05 282.89, 92.77 -70.66, -18.4 in-in in 9.663 Saltbr-in 2.732 HRD-in -60.32, -44.65 68.64, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.52, 164.81 APE9-dihe-na 71.13, 145.06 APE8-dihe-in -73.4, 143.68 APE8-rot-in 291.25 APE67-dihe-in -76.74, -22.26 -39.85, -46.81 APE12-dist-in 12.629 APE11-dist-in 10.535 APE10-dist-in 7.481 APE9-dist-in 3.099 None None None XRAY 2.28 0.245 0.29 A 387 348 22 0 0 0 [[80, 653]] 1.0 7zks Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.8e-139 470.0 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 4WUAA Q96SB4 69 655 655.0 3UL:701 Type1 Active DFGin 6.102 14.135 BLAminus -127.41, -171.15 54.73, 65.78 -81.43, 11.78 270.61, 76.74 -66.88, -14.14 in-in in 9.476 Saltbr-in 3.448 HRD-in -65.66, -44.4 71.86, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.69, 169.15 APE9-dihe-na 71.35, 146.29 APE8-dihe-in -69.47, 139.21 APE8-rot-in 296.34 APE67-dihe-in -67.85, -19.35 -35.93, -58.81 APE12-dist-in 12.772 APE11-dist-in 10.523 APE10-dist-in 7.58 APE9-dist-in 3.048 None None None XRAY 2.0 0.199 0.236 A 401 344 25 0 0 0 [[80, 653]] 1.0 4wua Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 5XV7A Q96SB4 67 655 655.0 EMH:705 Type1 Active DFGin 5.995 13.966 BLAminus -124.46, -177.25 65.64, 63.97 -83.12, 15.14 272.88, 70.82 -65.18, -13.48 in-in in 9.59 Saltbr-in 2.926 HRD-in -71.11, -43.72 78.74, -4.15 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.29, 164.0 APE9-dihe-na 73.39, 140.72 APE8-dihe-in -72.68, 146.09 APE8-rot-in 298.82 APE67-dihe-in -70.15, -17.54 -41.94, -55.9 APE12-dist-in 12.772 APE11-dist-in 10.486 APE10-dist-in 7.606 APE9-dist-in 3.05 None None None XRAY 2.32 0.213 0.238 A 372 350 22 0 0 0 [[80, 653]] 1.0 5xv7 Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.1e-138 467.4 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 5MXXA Q96SB4 56 655 655.0 W4A:701 Type1 Active DFGin 5.977 14.189 BLAminus -117.74, -175.37 55.98, 72.09 -86.99, 11.79 273.83, 86.12 -60.63, -21.63 in-in in 9.209 Saltbr-in 2.975 HRD-in -71.08, -46.72 78.08, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.86, 168.59 APE9-dihe-na 76.28, 126.73 APE8-dihe-in -50.41, 144.32 APE8-rot-in 293.68 APE67-dihe-in -70.94, -15.39 -51.89, -47.56 APE12-dist-in 12.738 APE11-dist-in 10.148 APE10-dist-in 7.396 APE9-dist-in 3.163 None None None XRAY 1.75 0.175 0.205 A 399 361 22 0 0 0 [[80, 653]] 1.0 5mxx Homo sapiens CMGC_SRPK1_HUMAN CMGC 9.4e-139 467.6 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 5MY8A Q96SB4 64 655 655.0 RXZ:724 Type1 Inactive DFGin 5.962 13.842 ABAminus -122.04, -29.62 -98.53, 98.95 -96.5, 16.27 273.03, 55.03 -66.84, -13.73 in-in in 9.198 Saltbr-in 2.945 HRD-in -70.3, -48.47 74.15, -9.5 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.15, 161.89 APE9-dihe-na 79.84, 140.15 APE8-dihe-in -69.93, 140.53 APE8-rot-in 296.54 APE67-dihe-in -70.56, -18.82 -39.68, -56.02 APE12-dist-in 12.76 APE11-dist-in 10.597 APE10-dist-in 7.655 APE9-dist-in 3.147 None None None XRAY 1.7 0.166 0.2 A 383 355 19 0 0 0 [[80, 653]] 1.0 5my8 Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 3BEGA Q96SB4 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.846 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.999 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.995 APE11-dist-in 10.441 APE10-dist-in 7.835 APE9-dist-in 3.062 None None None XRAY 2.9 0.24 0.298 A 381 348 21 0 0 0 [[80, 653]] 1.0 3beg Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 1WAKA Q96SB4 63 655 655.0 No_ligand No_ligand Inactive DFGin 6.205 14.675 BLAminus -123.0, -174.54 53.6, 68.83 -86.08, 19.05 272.45, 68.37 -61.63, -18.59 in-out in 9.935 Saltbr-out 4.386 HRD-in -70.54, -43.03 69.99, -4.62 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 167.9 APE9-dihe-na 70.72, 141.75 APE8-dihe-in -70.88, 141.01 APE8-rot-in 287.67 APE67-dihe-in -64.98, -18.19 -31.46, -62.63 APE12-dist-in 12.722 APE11-dist-in 10.369 APE10-dist-in 7.526 APE9-dist-in 3.114 None None None XRAY 1.73 0.198 0.218 A 397 353 21 0 0 0 [[80, 653]] 1.0 1wak Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 7DD1A Q96SB4 67 655 655.0 No_ligand No_ligand Inactive DFGin 6.087 14.461 BLAminus -126.87, 176.64 64.43, 66.57 -85.53, 15.97 273.29, 78.5 -65.27, -18.19 in-out in 9.846 Saltbr-out 4.308 HRD-in -64.64, -50.12 78.41, -7.9 out-in-in SNCoii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.14, 163.04 APE9-dihe-na 78.77, 142.36 APE8-dihe-in -68.04, 142.24 APE8-rot-in 297.31 APE67-dihe-in -67.62, -16.97 -42.36, -56.41 APE12-dist-in 12.774 APE11-dist-in 10.458 APE10-dist-in 7.547 APE9-dist-in 3.027 None None None XRAY 2.05 0.182 0.221 A 398 351 20 0 0 0 [[80, 653]] 1.0 7dd1 Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 6FADA Q96SB4 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.22 15.136 BLAminus -122.93, 179.12 57.38, 61.42 -78.03, 19.0 277.69, 78.02 -68.08, -18.77 in-out in 9.929 Saltbr-out 5.699 HRD-in -65.55, -50.38 76.6, 9.52 out-in-out SNCoio in-out ActLoopNT-in 3.046 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.2, 171.46 APE9-dihe-na 71.78, 143.02 APE8-dihe-in -86.05, 154.67 APE8-rot-out 81.2 APE67-dihe-in -62.54, -19.42 -41.68, -58.38 APE12-dist-in 12.82 APE11-dist-in 10.988 APE10-dist-in 7.672 APE9-dist-in 3.138 None None None XRAY 2.801 0.201 0.257 A 618 356 245 0 0 0 [[80, 653]] 1.0 6fad Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 6FADB Q96SB4 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.232 14.986 BLAminus -113.6, 174.2 60.21, 87.3 -102.47, 28.18 286.78, 61.47 -69.13, -15.83 in-out in 9.748 Saltbr-out 4.624 HRD-in -75.61, -45.96 73.19, 8.23 out-in-out SNCoio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.25, 164.85 APE9-dihe-na 73.22, 157.16 APE8-dihe-in -99.01, 141.77 APE8-rot-out 60.06 APE67-dihe-in -66.35, -13.73 -20.25, -68.69 APE12-dist-in 12.617 APE11-dist-in 10.907 APE10-dist-in 7.75 APE9-dist-in 3.18 None None None XRAY 2.801 0.201 0.257 B 618 356 245 0 0 0 [[80, 653]] 1.0 6fad Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 6FADC Q96SB4 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.517 15.295 BLAminus -123.52, -178.15 55.08, 85.74 -104.19, 20.56 276.3, 81.28 -67.88, -18.36 in-out in 9.967 Saltbr-out 5.558 HRD-in -74.58, -44.68 71.07, 8.29 out-in-in SNCoii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.77, 164.16 APE9-dihe-na 77.72, 151.02 APE8-dihe-in -86.55, 133.38 APE8-rot-in 273.9 APE67-dihe-in -62.07, -14.6 -22.9, -73.33 APE12-dist-in 12.691 APE11-dist-in 10.719 APE10-dist-in 7.639 APE9-dist-in 3.236 None None None XRAY 2.801 0.201 0.257 C 618 359 242 0 0 0 [[80, 653]] 1.0 6fad Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
SRPK1_HUMAN 6FADD Q96SB4 55 655 655.0 No_ligand No_ligand Inactive DFGin 6.377 15.33 BLAminus -119.7, -178.47 48.47, 81.81 -91.0, 13.61 274.63, 34.06 -64.49, -20.18 out-out out 10.194 Saltbr-out 5.179 HRD-in -73.88, -47.0 76.16, 9.55 out-in-in SNCoii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.69, 159.48 APE9-dihe-na 80.31, 146.18 APE8-dihe-in -75.32, 143.12 APE8-rot-in 297.81 APE67-dihe-in -63.2, -18.62 -40.87, -60.1 APE12-dist-in 12.786 APE11-dist-in 10.624 APE10-dist-in 7.756 APE9-dist-in 3.164 None None None XRAY 2.801 0.201 0.257 D 618 356 245 0 0 0 [[80, 653]] 1.0 6fad Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-138 466.8 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1

CMGC_SRPK1 (SRSF protein kinase 1)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name