TKL_RIPK4 (Receptor-interacting serine/threonine-protein kinase 4)

Total number of chains: 2
Active chains: 2
Family: TKL
Uniprot: RIPK4_HUMAN
Kinase Domain Residues: 22 - 285
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P57078-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P57078-K1A 14 293 832.0 No_ligand No_ligand Active DFGin 5.757 14.264 BLAminus -136.07, 175.34 62.97, 75.59 -93.63, 14.29 285.31, 79.66 -57.29, -36.14 in-in in 8.451 Saltbr-in 2.788 HRD-in -79.76, -42.9 65.09, -8.81 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.71, 154.12 APE9-dihe-na 88.06, 171.5 APE8-dihe-in -80.68, 110.48 APE8-rot-in 308.84 APE67-dihe-in -62.3, -15.99 -46.97, -42.78 APE12-dist-in 12.371 APE11-dist-in 12.45 APE10-dist-in 6.511 APE9-dist-in 4.09 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[20, 282]] 1.0 AF-P57078-K1 TKL_RIPK4_HUMAN TKL 3.4e-73 252.5 4 260 257 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
AF-P57078-K3A 14 293 832.0 No_ligand No_ligand Active DFGin 5.579 14.292 BLAminus -139.26, 176.23 65.02, 70.19 -91.25, 10.91 287.13, 82.1 -53.86, -43.4 in-in in 8.445 Saltbr-in 2.776 HRD-in -82.82, -41.92 66.27, -6.25 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.46, 125.58 APE9-dihe-na 88.08, 179.11 APE8-dihe-in -86.33, 111.75 APE8-rot-in 306.48 APE67-dihe-in -63.0, -22.25 -46.56, -40.5 APE12-dist-in 11.111 APE11-dist-in 11.822 APE10-dist-in 6.484 APE9-dist-in 3.777 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[20, 282]] 1.0 AF-P57078-K3 TKL_RIPK4_HUMAN TKL 3.4e-73 252.5 4 260 257 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4

TKL_RIPK4 (Receptor-interacting serine/threonine-protein kinase 4)

Total number of chains: 7
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 100.0% AF-P57078-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK4_HUMAN AF-P57078-K1A P57078 14 293 832.0 No_ligand No_ligand Active DFGin 5.757 14.264 BLAminus -136.07, 175.34 62.97, 75.59 -93.63, 14.29 285.31, 79.66 -57.29, -36.14 in-in in 8.451 Saltbr-in 2.788 HRD-in -79.76, -42.9 65.09, -8.81 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.71, 154.12 APE9-dihe-na 88.06, 171.5 APE8-dihe-in -80.68, 110.48 APE8-rot-in 308.84 APE67-dihe-in -62.3, -15.99 -46.97, -42.78 APE12-dist-in 12.371 APE11-dist-in 12.45 APE10-dist-in 6.511 APE9-dist-in 4.09 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[20, 282]] 1.0 AF-P57078-K1 Homo sapiens TKL_RIPK4_HUMAN TKL 3.4e-73 252.5 4 260 257 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_HUMAN AF-P57078-K3A P57078 14 293 832.0 No_ligand No_ligand Active DFGin 5.579 14.292 BLAminus -139.26, 176.23 65.02, 70.19 -91.25, 10.91 287.13, 82.1 -53.86, -43.4 in-in in 8.445 Saltbr-in 2.776 HRD-in -82.82, -41.92 66.27, -6.25 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.46, 125.58 APE9-dihe-na 88.08, 179.11 APE8-dihe-in -86.33, 111.75 APE8-rot-in 306.48 APE67-dihe-in -63.0, -22.25 -46.56, -40.5 APE12-dist-in 11.111 APE11-dist-in 11.822 APE10-dist-in 6.484 APE9-dist-in 3.777 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[20, 282]] 1.0 AF-P57078-K3 Homo sapiens TKL_RIPK4_HUMAN TKL 3.4e-73 252.5 4 260 257 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.031 14.764 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.646 Saltbr-in 2.482 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.204 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.458 APE9-dist-out 11.387 D143N None None XRAY 2.65 0.204 0.248 A 342 263 17 0 0 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNJA Q9ERK0 10 289 786.0 2V9:401 Type1 Inactive DFGin 5.26 14.664 BLAminus -127.8, -174.68 60.62, 84.85 -99.96, 17.65 286.18, 74.24 -54.52, -35.7 in-in in 8.996 Saltbr-in 2.85 HRD-in -77.0, -51.72 66.97, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.967 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -159.19 APE9-dihe-na -75.21, -3.62 APE8-dihe-out -71.73, -9.01 APE8-rot-out 66.05 APE67-dihe-in -63.24, -28.73 -58.74, -34.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.185 APE9-dist-out 11.743 D143N None None XRAY 2.55 0.221 0.252 A 342 264 16 0 0 14 [[19, 285]] 1.0 5wnj Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.357 14.572 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.778 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.665 APE9-dist-out 11.709 D143N None None XRAY 2.5 0.224 0.256 A 342 262 17 0 0 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNMA Q9ERK0 10 289 786.0 VX6:402 Type1 Inactive DFGin 5.319 15.019 BLAminus -138.47, -173.35 66.95, 80.24 -100.95, 14.98 287.3, 82.71 -66.01, -27.94 in-in in 8.863 Saltbr-in 3.123 HRD-in -74.82, -52.55 67.3, 1.99 in-in-out SNCiio in-out ActLoopNT-in 3.169 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -172.61 APE9-dihe-na -73.45, -0.59 APE8-dihe-out -73.9, -0.77 APE8-rot-out 64.59 APE67-dihe-in -62.49, -30.21 -58.8, -36.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.162 APE9-dist-out 12.275 D143N None None XRAY 2.6 0.23 0.264 A 342 263 17 0 0 15 [[19, 285]] 1.0 5wnm Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNKA Q9ERK0 10 288 786.0 B6J:402 Type1.5_Back Inactive DFGin 5.256 15.171 BLAminus -137.28, 178.62 66.12, 79.02 -94.27, 22.97 288.71, 82.14 -63.85, -29.75 in-in in 9.039 Saltbr-in 2.899 HRD-in -77.2, -54.76 66.83, 7.58 in-in-out SNCiio in-out ActLoopNT-in 3.112 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -156.44 APE9-dihe-na -80.82, 15.15 APE8-dihe-out -95.14, 12.77 APE8-rot-out 81.95 APE67-dihe-in -55.32, -32.41 -60.65, -34.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.49 APE9-dist-out 13.089 D143N None None XRAY 3.11 0.228 0.272 A 342 263 16 0 0 14 [[19, 285]] 1.0 5wnk Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4

TKL_RIPK4 (Receptor-interacting serine/threonine-protein kinase 4)

Total number of chains: 5
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 5WNJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.031 14.764 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.646 Saltbr-in 2.482 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.204 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.458 APE9-dist-out 11.387 D143N None None XRAY 2.65 0.204 0.248 A 342 263 17 0 0 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNJA Q9ERK0 10 289 786.0 2V9:401 Type1 Inactive DFGin 5.26 14.664 BLAminus -127.8, -174.68 60.62, 84.85 -99.96, 17.65 286.18, 74.24 -54.52, -35.7 in-in in 8.996 Saltbr-in 2.85 HRD-in -77.0, -51.72 66.97, 3.03 in-in-out SNCiio in-out ActLoopNT-in 2.967 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -159.19 APE9-dihe-na -75.21, -3.62 APE8-dihe-out -71.73, -9.01 APE8-rot-out 66.05 APE67-dihe-in -63.24, -28.73 -58.74, -34.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.185 APE9-dist-out 11.743 D143N None None XRAY 2.55 0.221 0.252 A 342 264 16 0 0 14 [[19, 285]] 1.0 5wnj Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNLA Q9ERK0 10 288 786.0 STU:401 Type1 Inactive DFGin 5.357 14.572 BLAminus -134.03, 174.48 63.33, 81.72 -96.92, 21.29 289.3, 76.96 -59.26, -33.93 in-in in 8.778 Saltbr-in 2.733 HRD-in -81.33, -54.8 69.56, 11.14 in-in-out SNCiio in-out ActLoopNT-in 3.066 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 144.67 APE9-dihe-na 85.9, -57.36 APE8-dihe-out -63.74, -13.96 APE8-rot-out 59.65 APE67-dihe-in -59.52, -31.71 -58.84, -41.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.665 APE9-dist-out 11.709 D143N None None XRAY 2.5 0.224 0.256 A 342 262 17 0 0 14 [[19, 285]] 1.0 5wnl Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNMA Q9ERK0 10 289 786.0 VX6:402 Type1 Inactive DFGin 5.319 15.019 BLAminus -138.47, -173.35 66.95, 80.24 -100.95, 14.98 287.3, 82.71 -66.01, -27.94 in-in in 8.863 Saltbr-in 3.123 HRD-in -74.82, -52.55 67.3, 1.99 in-in-out SNCiio in-out ActLoopNT-in 3.169 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -172.61 APE9-dihe-na -73.45, -0.59 APE8-dihe-out -73.9, -0.77 APE8-rot-out 64.59 APE67-dihe-in -62.49, -30.21 -58.8, -36.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.162 APE9-dist-out 12.275 D143N None None XRAY 2.6 0.23 0.264 A 342 263 17 0 0 15 [[19, 285]] 1.0 5wnm Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
RIPK4_MOUSE 5WNKA Q9ERK0 10 288 786.0 B6J:402 Type1.5_Back Inactive DFGin 5.256 15.171 BLAminus -137.28, 178.62 66.12, 79.02 -94.27, 22.97 288.71, 82.14 -63.85, -29.75 in-in in 9.039 Saltbr-in 2.899 HRD-in -77.2, -54.76 66.83, 7.58 in-in-out SNCiio in-out ActLoopNT-in 3.112 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -156.44 APE9-dihe-na -80.82, 15.15 APE8-dihe-out -95.14, 12.77 APE8-rot-out 81.95 APE67-dihe-in -55.32, -32.41 -60.65, -34.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.49 APE9-dist-out 13.089 D143N None None XRAY 3.11 0.228 0.272 A 342 263 16 0 0 14 [[19, 285]] 1.0 5wnk Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4