CAMK_MARK4 (MAP/microtubule affinity-regulating kinase 4)

Total number of chains: 5
Active chains: 2
Uniprot: MARK4_HUMAN
Kinase Domain Residues: 59 - 310
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q96L34-K1A
DFGin BLBtrans 1 20.0% 8XFLA
DFGin None 1 20.0% 5ES1A
None None 1 20.0% 8XFLB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK4 AF-Q96L34-K1A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.6104 14.5155 BLAminus -122.78, 175.62 57.43, 75.4 -83.51, 15.79 288.38, 81.6 -61.42, -29.89 in-in in 9.4033 Saltbr-in 2.676 HRD-in -81.36, -46.98 64.62, 5.83 in-in-in SNCiii in-in ActLoopNT-in 2.9054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 160.83 APE9-dihe-na 91.36, 178.14 APE8-dihe-in -82.25, 129.5 APE8-rot-in 305.11 APE67-dihe-in -65.1, -22.7 -52.5, -39.41 APE12-dist-in 8.6594 APE11-dist-in 10.9359 APE10-dist-in 5.1039 APE9-dist-in 3.3866 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[59, 310]] 1.0 AF-Q96L34-K1 CAMK_MARK4_HUMAN CAMK 1.1e-96 328.9 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 AF-Q96L34-K3A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.2676 14.5021 BLAminus -124.44, 174.67 54.29, 75.08 -77.96, 14.05 285.8, 83.65 -59.86, -26.8 in-in in 9.4143 Saltbr-in 2.713 HRD-in -85.11, -44.75 64.68, -2.73 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.5, 179.0 APE9-dihe-na 103.89, 166.78 APE8-dihe-in -78.31, 124.02 APE8-rot-in 298.22 APE67-dihe-in -65.41, -21.73 -51.15, -39.73 APE12-dist-in 8.312 APE11-dist-in 11.2027 APE10-dist-in 5.7134 APE9-dist-in 3.2046 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[59, 310]] 1.0 AF-Q96L34-K3 CAMK_MARK4_HUMAN CAMK 1.1e-96 328.9 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 8XFLA Q96L34 54 370 752.0 No_ligand No_ligand Inactive DFGin 10.4917 18.8793 BLBtrans -123.54, 158.64 55.11, 20.99 -76.15, 106.53 186.05, 100.9 110.14, -9.7 out-out out 11.4427 Saltbr-out 7.7625 HRD-in -68.78, -51.6 63.63, 5.58 out-out-none SNCoon out-none ActLoopNT-out 9.6302 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.09, -45.47 999.0, -44.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.21 0.27 A 327.0 299.0 18 27 16 11 [[59, 310]] 1.0 8xfl CAMK_MARK4_HUMAN CAMK 2.3e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 5ES1A Q96L34 54 370 752.0 5RC:64000 Type1 Inactive DFGin 7.2886 14.3491 None -110.73, 167.87 94.58, -106.37 80.67, 9.01 291.5, 96.97 -62.77, -44.52 in-in in 9.1567 Saltbr-in 3.05 HRD-in -47.94, -47.33 60.65, 3.33 in-in-none SNCiin in-none ActLoopNT-in 3.2249 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.88 APE8-rot-none 999.0 APE67-dihe-in -54.77, -17.8 -67.3, -52.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.243 0.311 A 328.0 304.0 13 27 14 13 [[59, 310]] 1.0 5es1 CAMK_MARK4_HUMAN CAMK 2.4e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 8XFLB Q96L34 54 370 752.0 No_ligand No_ligand Inactive None 11.1363 18.7475 None -126.86, 158.08 54.89, 16.95 -83.94, 106.07 181.25, 82.91 106.86, 3.55 out-out out 11.5101 Saltbr-out 10.9748 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.21 0.27 B 327.0 278.0 39 27 9 18 [[59, 310]] 1.0 8xfl CAMK_MARK4_HUMAN CAMK 2.3e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4

CAMK_MARK4 (MAP/microtubule affinity-regulating kinase 4)

Total number of chains: 5
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 40.0% AF-Q96L34-K1A
DFGin BLBtrans 1 20.0% 8XFLA
DFGin None 1 20.0% 5ES1A
None None 1 20.0% 8XFLB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK4 MARK4_HUMAN AF-Q96L34-K1A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.6104 14.5155 BLAminus -122.78, 175.62 57.43, 75.4 -83.51, 15.79 288.38, 81.6 -61.42, -29.89 in-in in 9.4033 Saltbr-in 2.676 HRD-in -81.36, -46.98 64.62, 5.83 in-in-in SNCiii in-in ActLoopNT-in 2.9054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 160.83 APE9-dihe-na 91.36, 178.14 APE8-dihe-in -82.25, 129.5 APE8-rot-in 305.11 APE67-dihe-in -65.1, -22.7 -52.5, -39.41 APE12-dist-in 8.6594 APE11-dist-in 10.9359 APE10-dist-in 5.1039 APE9-dist-in 3.3866 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[59, 310]] 1.0 AF-Q96L34-K1 Homo sapiens CAMK_MARK4_HUMAN CAMK 1.1e-96 328.9 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 MARK4_HUMAN AF-Q96L34-K3A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.2676 14.5021 BLAminus -124.44, 174.67 54.29, 75.08 -77.96, 14.05 285.8, 83.65 -59.86, -26.8 in-in in 9.4143 Saltbr-in 2.713 HRD-in -85.11, -44.75 64.68, -2.73 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.5, 179.0 APE9-dihe-na 103.89, 166.78 APE8-dihe-in -78.31, 124.02 APE8-rot-in 298.22 APE67-dihe-in -65.41, -21.73 -51.15, -39.73 APE12-dist-in 8.312 APE11-dist-in 11.2027 APE10-dist-in 5.7134 APE9-dist-in 3.2046 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[59, 310]] 1.0 AF-Q96L34-K3 Homo sapiens CAMK_MARK4_HUMAN CAMK 1.1e-96 328.9 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 MARK4_HUMAN 8XFLA Q96L34 54 370 752.0 No_ligand No_ligand Inactive DFGin 10.4917 18.8793 BLBtrans -123.54, 158.64 55.11, 20.99 -76.15, 106.53 186.05, 100.9 110.14, -9.7 out-out out 11.4427 Saltbr-out 7.7625 HRD-in -68.78, -51.6 63.63, 5.58 out-out-none SNCoon out-none ActLoopNT-out 9.6302 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.09, -45.47 999.0, -44.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.21 0.27 A 327.0 299.0 18 27 16 11 [[59, 310]] 1.0 8xfl Homo sapiens CAMK_MARK4_HUMAN CAMK 2.3e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 MARK4_HUMAN 5ES1A Q96L34 54 370 752.0 5RC:64000 Type1 Inactive DFGin 7.2886 14.3491 None -110.73, 167.87 94.58, -106.37 80.67, 9.01 291.5, 96.97 -62.77, -44.52 in-in in 9.1567 Saltbr-in 3.05 HRD-in -47.94, -47.33 60.65, 3.33 in-in-none SNCiin in-none ActLoopNT-in 3.2249 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.88 APE8-rot-none 999.0 APE67-dihe-in -54.77, -17.8 -67.3, -52.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.243 0.311 A 328.0 304.0 13 27 14 13 [[59, 310]] 1.0 5es1 Homo sapiens CAMK_MARK4_HUMAN CAMK 2.4e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
MARK4 MARK4_HUMAN 8XFLB Q96L34 54 370 752.0 No_ligand No_ligand Inactive None 11.1363 18.7475 None -126.86, 158.08 54.89, 16.95 -83.94, 106.07 181.25, 82.91 106.86, 3.55 out-out out 11.5101 Saltbr-out 10.9748 HRD-none 999.0, 999.0 999.0, 999.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.21 0.27 B 327.0 278.0 39 27 9 18 [[59, 310]] 1.0 8xfl Homo sapiens CAMK_MARK4_HUMAN CAMK 2.3e-96 328.0 1.0 256.0 256.0 198 199 200 202 204 88 106 110 178 180 179 181.0 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4

CAMK_MARK4 (MAP/microtubule affinity-regulating kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name