CAMK_MARK1 (Serine/threonine-protein kinase MARK1)

Total number of chains: 12
Active chains: 2
Family: CAMK
Uniprot: MARK1_HUMAN
Kinase Domain Residues: 60 - 311
Spatial label Dihedral label Number of Chains Percent Representative
None None 8 66.7% 2HAKE
DFGin BLAminus 4 33.3% AF-Q9P0L2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9P0L2-K1A 52 319 795.0 No_ligand No_ligand Active DFGin 6.625 14.547 BLAminus -122.98, 175.78 56.96, 74.47 -82.32, 16.31 287.99, 81.42 -61.89, -29.97 in-in in 9.419 Saltbr-in 2.672 HRD-in -80.47, -47.8 64.59, 7.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 160.03 APE9-dihe-na 92.74, 171.97 APE8-dihe-in -71.38, 130.98 APE8-rot-in 280.72 APE67-dihe-in -65.29, -22.67 -52.54, -38.97 APE12-dist-in 8.628 APE11-dist-in 10.932 APE10-dist-in 5.135 APE9-dist-in 3.448 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K1 CAMK_MARK1_HUMAN CAMK 4.5e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
AF-Q9P0L2-K3A 52 319 795.0 No_ligand No_ligand Active DFGin 6.299 14.455 BLAminus -124.46, 174.9 53.8, 76.93 -79.51, 14.6 286.75, 85.5 -59.82, -27.14 in-in in 9.352 Saltbr-in 2.668 HRD-in -83.94, -45.21 65.05, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.32, -179.8 APE9-dihe-na 99.63, 167.85 APE8-dihe-in -79.1, 124.28 APE8-rot-in 299.06 APE67-dihe-in -64.9, -22.13 -51.43, -39.55 APE12-dist-in 8.264 APE11-dist-in 11.214 APE10-dist-in 5.7 APE9-dist-in 3.223 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K3 CAMK_MARK1_HUMAN CAMK 4.5e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
6C9DA 53 795 795.0 No_ligand No_ligand Inactive DFGin 6.909 14.466 BLAminus -130.25, 175.17 52.56, 70.96 -76.16, 26.89 291.73, 78.45 -62.38, -38.33 in-in in 9.346 Saltbr-in 2.538 HRD-in -85.07, -52.72 70.59, 5.86 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.61, -27.45 APE9-dihe-na -75.42, -174.1 APE8-dihe-in -73.96, 141.96 APE8-rot-out 209.65 APE67-dihe-in -60.87, -23.67 -60.78, -46.82 APE12-dist-in 8.048 APE11-dist-in 10.367 APE10-dist-in 4.747 APE9-dist-in 3.395 T215E,K761S,R764S None None XRAY 2.499 0.206 0.251 A 459 425 0 0 0 0 [[60, 311]] 1.0 6c9d CAMK_MARK1_HUMAN CAMK 5.9e-96 326.8 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
6C9DB 53 795 795.0 No_ligand No_ligand Inactive DFGin 6.936 14.688 BLAminus -129.09, 172.57 53.34, 71.8 -74.34, 27.05 292.24, 74.28 -63.26, -38.97 in-in in 9.687 Saltbr-in 3.452 HRD-in -83.24, -51.44 70.59, 6.77 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.09, -27.5 APE9-dihe-na -76.1, -176.83 APE8-dihe-in -72.41, 141.66 APE8-rot-out 209.6 APE67-dihe-in -58.16, -26.49 -60.51, -42.44 APE12-dist-in 8.365 APE11-dist-in 10.775 APE10-dist-in 4.923 APE9-dist-in 3.358 T215E,K761S,R764S None None XRAY 2.499 0.206 0.251 B 459 422 0 0 0 0 [[60, 311]] 1.0 6c9d CAMK_MARK1_HUMAN CAMK 5.9e-96 326.8 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKA 55 371 795.0 No_ligand No_ligand Inactive None 14.23 21.479 None -136.2, 129.3 59.38, 36.71 -66.46, 118.42 181.86, 31.47 88.64, 11.96 in-out in 9.869 Saltbr-out 6.089 HRD-out -104.22, 4.09 -147.4, 168.26 out-out-out SNCooo out-out ActLoopNT-out 13.189 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -101.42 APE8-dihe-in -129.52, 140.71 APE8-rot-out 56.48 APE67-dihe-out -51.78, -25.66 -54.26, 147.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 17.087 None None None XRAY 2.6 0.214 0.29 A 328 309 8 0 0 8 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKB 53 371 795.0 No_ligand No_ligand Inactive None 13.758 21.207 None -139.18, 116.16 75.9, 39.73 -67.64, 126.71 172.85, 29.02 81.81, 9.74 out-out out 10.261 Saltbr-out 5.311 HRD-out -85.27, -93.83 -46.24, 172.42 out-out-none SNCoon out-none ActLoopNT-out 12.229 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 B 328 279 36 0 0 18 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKC 53 371 795.0 No_ligand No_ligand Inactive None 13.79 21.269 None -130.58, 141.5 63.56, 24.92 -66.4, 116.33 173.41, 34.7 92.18, 0.6 out-out out 10.181 Saltbr-out 6.419 HRD-out -115.66, -9.05 -140.44, 146.87 out-out-none SNCoon out-none ActLoopNT-out 13.305 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.72, -4.53 999.0, 116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 C 328 310 9 0 0 9 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKD 54 371 795.0 No_ligand No_ligand Inactive None 13.584 21.261 None -110.84, 133.2 68.62, 39.68 -70.03, 115.89 175.89, 36.0 79.21, 3.81 out-out out 10.343 Saltbr-out 6.02 HRD-out -92.77, 3.76 -159.04, 156.32 out-out-none SNCoon out-none ActLoopNT-out 12.729 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -83.21, 10.59 999.0, 39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 D 328 309 9 0 0 9 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKE 54 371 795.0 No_ligand No_ligand Inactive None 13.851 21.49 None -137.02, 128.22 72.29, 22.66 -49.86, 108.34 181.74, 18.88 97.36, 5.36 out-out out 10.535 Saltbr-out 5.291 HRD-out -90.62, -1.58 -155.38, 151.73 out-out-out SNCooo out-out ActLoopNT-out 12.822 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.85, -15.22 APE9-dihe-na -82.15, -31.67 APE8-dihe-out -108.57, -11.7 APE8-rot-out 34.72 APE67-dihe-in -70.84, -1.88 -58.73, -26.66 APE12-dist-out 14.563 APE11-dist-out 18.861 APE10-dist-out 21.378 APE9-dist-out 16.383 None None None XRAY 2.6 0.214 0.29 E 328 318 0 0 0 0 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKF 54 371 795.0 No_ligand No_ligand Inactive None 13.711 20.639 None -131.21, 137.08 60.34, 30.23 -59.56, 117.2 178.23, 31.91 86.87, -8.61 out-out out 10.057 Saltbr-out 6.503 HRD-out -102.11, -12.63 -138.93, 156.98 out-out-out SNCooo out-out ActLoopNT-out 12.316 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.89, 34.25 APE9-dihe-na 76.84, -78.57 APE8-dihe-in -95.43, 133.76 APE8-rot-in 305.41 APE67-dihe-out -65.62, -8.44 -70.8, 151.85 APE12-dist-out 14.239 APE11-dist-out 19.28 APE10-dist-out 20.151 APE9-dist-out 15.981 None None None XRAY 2.6 0.214 0.29 F 328 318 0 0 0 0 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKG 55 371 795.0 No_ligand No_ligand Inactive None 13.869 21.375 None -148.32, 130.06 69.43, 32.01 -73.81, 98.7 175.37, 35.78 118.9, -22.81 in-out in 9.971 Saltbr-out 5.237 HRD-out -100.43, -36.08 -111.48, -155.41 out-out-out SNCooo out-out ActLoopNT-out 12.141 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.33 APE8-rot-in 253.64 APE67-dihe-out -47.77, 6.56 -101.52, 143.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 G 328 297 20 0 0 10 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
2HAKH 54 371 795.0 No_ligand No_ligand Inactive None 14.207 21.16 None -136.83, 137.16 62.15, 42.58 -77.54, 119.42 169.7, 25.4 79.11, 4.89 out-out out 10.088 Saltbr-out 5.008 HRD-out -90.14, -19.23 -134.33, 161.46 out-out-none SNCoon out-none ActLoopNT-out 12.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 H 328 277 41 0 0 17 [[60, 311]] 1.0 2hak CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1

CAMK_MARK1 (Serine/threonine-protein kinase MARK1)

Total number of chains: 12
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
None None 8 66.7% 2HAKE
DFGin BLAminus 4 33.3% AF-Q9P0L2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK1_HUMAN AF-Q9P0L2-K1A Q9P0L2 52 319 795.0 No_ligand No_ligand Active DFGin 6.625 14.547 BLAminus -122.98, 175.78 56.96, 74.47 -82.32, 16.31 287.99, 81.42 -61.89, -29.97 in-in in 9.419 Saltbr-in 2.672 HRD-in -80.47, -47.8 64.59, 7.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 160.03 APE9-dihe-na 92.74, 171.97 APE8-dihe-in -71.38, 130.98 APE8-rot-in 280.72 APE67-dihe-in -65.29, -22.67 -52.54, -38.97 APE12-dist-in 8.628 APE11-dist-in 10.932 APE10-dist-in 5.135 APE9-dist-in 3.448 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K1 Homo sapiens CAMK_MARK1_HUMAN CAMK 4.5e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN AF-Q9P0L2-K3A Q9P0L2 52 319 795.0 No_ligand No_ligand Active DFGin 6.299 14.455 BLAminus -124.46, 174.9 53.8, 76.93 -79.51, 14.6 286.75, 85.5 -59.82, -27.14 in-in in 9.352 Saltbr-in 2.668 HRD-in -83.94, -45.21 65.05, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.32, -179.8 APE9-dihe-na 99.63, 167.85 APE8-dihe-in -79.1, 124.28 APE8-rot-in 299.06 APE67-dihe-in -64.9, -22.13 -51.43, -39.55 APE12-dist-in 8.264 APE11-dist-in 11.214 APE10-dist-in 5.7 APE9-dist-in 3.223 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K3 Homo sapiens CAMK_MARK1_HUMAN CAMK 4.5e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 6C9DA Q9P0L2 53 795 795.0 No_ligand No_ligand Inactive DFGin 6.909 14.466 BLAminus -130.25, 175.17 52.56, 70.96 -76.16, 26.89 291.73, 78.45 -62.38, -38.33 in-in in 9.346 Saltbr-in 2.538 HRD-in -85.07, -52.72 70.59, 5.86 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.61, -27.45 APE9-dihe-na -75.42, -174.1 APE8-dihe-in -73.96, 141.96 APE8-rot-out 209.65 APE67-dihe-in -60.87, -23.67 -60.78, -46.82 APE12-dist-in 8.048 APE11-dist-in 10.367 APE10-dist-in 4.747 APE9-dist-in 3.395 T215E,K761S,R764S None None XRAY 2.499 0.206 0.251 A 459 425 0 0 0 0 [[60, 311]] 1.0 6c9d Homo sapiens CAMK_MARK1_HUMAN CAMK 5.9e-96 326.8 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 6C9DB Q9P0L2 53 795 795.0 No_ligand No_ligand Inactive DFGin 6.936 14.688 BLAminus -129.09, 172.57 53.34, 71.8 -74.34, 27.05 292.24, 74.28 -63.26, -38.97 in-in in 9.687 Saltbr-in 3.452 HRD-in -83.24, -51.44 70.59, 6.77 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -111.09, -27.5 APE9-dihe-na -76.1, -176.83 APE8-dihe-in -72.41, 141.66 APE8-rot-out 209.6 APE67-dihe-in -58.16, -26.49 -60.51, -42.44 APE12-dist-in 8.365 APE11-dist-in 10.775 APE10-dist-in 4.923 APE9-dist-in 3.358 T215E,K761S,R764S None None XRAY 2.499 0.206 0.251 B 459 422 0 0 0 0 [[60, 311]] 1.0 6c9d Homo sapiens CAMK_MARK1_HUMAN CAMK 5.9e-96 326.8 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKA Q9P0L2 55 371 795.0 No_ligand No_ligand Inactive None 14.23 21.479 None -136.2, 129.3 59.38, 36.71 -66.46, 118.42 181.86, 31.47 88.64, 11.96 in-out in 9.869 Saltbr-out 6.089 HRD-out -104.22, 4.09 -147.4, 168.26 out-out-out SNCooo out-out ActLoopNT-out 13.189 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -101.42 APE8-dihe-in -129.52, 140.71 APE8-rot-out 56.48 APE67-dihe-out -51.78, -25.66 -54.26, 147.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 17.087 None None None XRAY 2.6 0.214 0.29 A 328 309 8 0 0 8 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKB Q9P0L2 53 371 795.0 No_ligand No_ligand Inactive None 13.758 21.207 None -139.18, 116.16 75.9, 39.73 -67.64, 126.71 172.85, 29.02 81.81, 9.74 out-out out 10.261 Saltbr-out 5.311 HRD-out -85.27, -93.83 -46.24, 172.42 out-out-none SNCoon out-none ActLoopNT-out 12.229 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 B 328 279 36 0 0 18 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKC Q9P0L2 53 371 795.0 No_ligand No_ligand Inactive None 13.79 21.269 None -130.58, 141.5 63.56, 24.92 -66.4, 116.33 173.41, 34.7 92.18, 0.6 out-out out 10.181 Saltbr-out 6.419 HRD-out -115.66, -9.05 -140.44, 146.87 out-out-none SNCoon out-none ActLoopNT-out 13.305 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.72, -4.53 999.0, 116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 C 328 310 9 0 0 9 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKD Q9P0L2 54 371 795.0 No_ligand No_ligand Inactive None 13.584 21.261 None -110.84, 133.2 68.62, 39.68 -70.03, 115.89 175.89, 36.0 79.21, 3.81 out-out out 10.343 Saltbr-out 6.02 HRD-out -92.77, 3.76 -159.04, 156.32 out-out-none SNCoon out-none ActLoopNT-out 12.729 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -83.21, 10.59 999.0, 39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 D 328 309 9 0 0 9 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKE Q9P0L2 54 371 795.0 No_ligand No_ligand Inactive None 13.851 21.49 None -137.02, 128.22 72.29, 22.66 -49.86, 108.34 181.74, 18.88 97.36, 5.36 out-out out 10.535 Saltbr-out 5.291 HRD-out -90.62, -1.58 -155.38, 151.73 out-out-out SNCooo out-out ActLoopNT-out 12.822 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.85, -15.22 APE9-dihe-na -82.15, -31.67 APE8-dihe-out -108.57, -11.7 APE8-rot-out 34.72 APE67-dihe-in -70.84, -1.88 -58.73, -26.66 APE12-dist-out 14.563 APE11-dist-out 18.861 APE10-dist-out 21.378 APE9-dist-out 16.383 None None None XRAY 2.6 0.214 0.29 E 328 318 0 0 0 0 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKF Q9P0L2 54 371 795.0 No_ligand No_ligand Inactive None 13.711 20.639 None -131.21, 137.08 60.34, 30.23 -59.56, 117.2 178.23, 31.91 86.87, -8.61 out-out out 10.057 Saltbr-out 6.503 HRD-out -102.11, -12.63 -138.93, 156.98 out-out-out SNCooo out-out ActLoopNT-out 12.316 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.89, 34.25 APE9-dihe-na 76.84, -78.57 APE8-dihe-in -95.43, 133.76 APE8-rot-in 305.41 APE67-dihe-out -65.62, -8.44 -70.8, 151.85 APE12-dist-out 14.239 APE11-dist-out 19.28 APE10-dist-out 20.151 APE9-dist-out 15.981 None None None XRAY 2.6 0.214 0.29 F 328 318 0 0 0 0 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKG Q9P0L2 55 371 795.0 No_ligand No_ligand Inactive None 13.869 21.375 None -148.32, 130.06 69.43, 32.01 -73.81, 98.7 175.37, 35.78 118.9, -22.81 in-out in 9.971 Saltbr-out 5.237 HRD-out -100.43, -36.08 -111.48, -155.41 out-out-out SNCooo out-out ActLoopNT-out 12.141 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.33 APE8-rot-in 253.64 APE67-dihe-out -47.77, 6.56 -101.52, 143.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 G 328 297 20 0 0 10 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
MARK1_HUMAN 2HAKH Q9P0L2 54 371 795.0 No_ligand No_ligand Inactive None 14.207 21.16 None -136.83, 137.16 62.15, 42.58 -77.54, 119.42 169.7, 25.4 79.11, 4.89 out-out out 10.088 Saltbr-out 5.008 HRD-out -90.14, -19.23 -134.33, 161.46 out-out-none SNCoon out-none ActLoopNT-out 12.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.214 0.29 H 328 277 41 0 0 17 [[60, 311]] 1.0 2hak Homo sapiens CAMK_MARK1_HUMAN CAMK 9.3e-97 329.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1

CAMK_MARK1 (Serine/threonine-protein kinase MARK1)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name