STE_MAP3K4 (Mitogen-activated protein kinase kinase kinase 4)

Total number of chains: 2
Active chains: 1
Uniprot: M3K4_HUMAN
Kinase Domain Residues: 1343 - 1601
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q9Y6R4-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K4 AF-Q9Y6R4-K3A Q9Y6R4 1335 1608 1608.0 No_ligand No_ligand Active DFGin 6.1532 13.956 BLAminus -137.4, -165.83 54.14, 61.99 -75.01, 10.39 302.43, 97.75 -63.44, -26.42 in-in in 9.3124 Saltbr-in 2.8918 HRD-in -76.2, -44.74 67.68, -6.25 in-in-in SNCiii in-in ActLoopNT-in 2.9514 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 151.28 APE9-dihe-na 123.24, 178.94 APE8-dihe-in -92.97, 124.8 APE8-rot-in 302.29 APE67-dihe-in -65.05, -17.33 -50.31, -38.33 APE12-dist-in 9.0294 APE11-dist-in 11.4515 APE10-dist-in 5.4871 APE9-dist-in 3.1116 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 32 32 0 [[1343, 1601]] 1.0 AF-Q9Y6R4-K3 STE_MAP3K4_HUMAN STE 1.8e-78 269.3 1.0 257.0 257.0 1480 1481 1482 1484 1486 1372 1390 1394 1460 1462 1461 1463.0 1527 1512 1507 1506 1505 1504 1503 1502 1501 1420 Mitogen-activated protein kinase kinase kinase 4
MAP3K4 AF-Q9Y6R4-K1A Q9Y6R4 1335 1608 1608.0 No_ligand No_ligand Inactive DFGin 6.1705 14.2853 BLAminus -141.02, -166.79 54.3, 70.41 -82.88, 14.66 294.95, 82.53 -58.3, -27.51 in-in in 9.7182 Saltbr-in 3.0601 HRD-in -83.91, -45.18 64.02, 10.01 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -69.49, 141.27 APE9-dihe-na -48.4, 177.08 APE8-dihe-in -60.24, 127.2 APE8-rot-in 300.39 APE67-dihe-in -59.1, -20.89 -48.87, -33.17 APE12-dist-in 11.8097 APE11-dist-out 6.4272 APE10-dist-in 7.5361 APE9-dist-in 4.0385 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 32 32 0 [[1343, 1601]] 1.0 AF-Q9Y6R4-K1 STE_MAP3K4_HUMAN STE 1.8e-78 269.3 1.0 257.0 257.0 1480 1481 1482 1484 1486 1372 1390 1394 1460 1462 1461 1463.0 1527 1512 1507 1506 1505 1504 1503 1502 1501 1420 Mitogen-activated protein kinase kinase kinase 4

STE_MAP3K4 (Mitogen-activated protein kinase kinase kinase 4)

Total number of chains: 2
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-Q9Y6R4-K3A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K3A Q9Y6R4 1335 1608 1608.0 No_ligand No_ligand Active DFGin 6.1532 13.956 BLAminus -137.4, -165.83 54.14, 61.99 -75.01, 10.39 302.43, 97.75 -63.44, -26.42 in-in in 9.3124 Saltbr-in 2.8918 HRD-in -76.2, -44.74 67.68, -6.25 in-in-in SNCiii in-in ActLoopNT-in 2.9514 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.25, 151.28 APE9-dihe-na 123.24, 178.94 APE8-dihe-in -92.97, 124.8 APE8-rot-in 302.29 APE67-dihe-in -65.05, -17.33 -50.31, -38.33 APE12-dist-in 9.0294 APE11-dist-in 11.4515 APE10-dist-in 5.4871 APE9-dist-in 3.1116 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 32 32 0 [[1343, 1601]] 1.0 AF-Q9Y6R4-K3 Homo sapiens STE_MAP3K4_HUMAN STE 1.8e-78 269.3 1.0 257.0 257.0 1480 1481 1482 1484 1486 1372 1390 1394 1460 1462 1461 1463.0 1527 1512 1507 1506 1505 1504 1503 1502 1501 1420 Mitogen-activated protein kinase kinase kinase 4
MAP3K4 M3K4_HUMAN AF-Q9Y6R4-K1A Q9Y6R4 1335 1608 1608.0 No_ligand No_ligand Inactive DFGin 6.1705 14.2853 BLAminus -141.02, -166.79 54.3, 70.41 -82.88, 14.66 294.95, 82.53 -58.3, -27.51 in-in in 9.7182 Saltbr-in 3.0601 HRD-in -83.91, -45.18 64.02, 10.01 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -69.49, 141.27 APE9-dihe-na -48.4, 177.08 APE8-dihe-in -60.24, 127.2 APE8-rot-in 300.39 APE67-dihe-in -59.1, -20.89 -48.87, -33.17 APE12-dist-in 11.8097 APE11-dist-out 6.4272 APE10-dist-in 7.5361 APE9-dist-in 4.0385 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 32 32 0 [[1343, 1601]] 1.0 AF-Q9Y6R4-K1 Homo sapiens STE_MAP3K4_HUMAN STE 1.8e-78 269.3 1.0 257.0 257.0 1480 1481 1482 1484 1486 1372 1390 1394 1460 1462 1461 1463.0 1527 1512 1507 1506 1505 1504 1503 1502 1501 1420 Mitogen-activated protein kinase kinase kinase 4

STE_MAP3K4 (Mitogen-activated protein kinase kinase kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name