STE_MAP2K3 (Dual specificity mitogen-activated protein kinase kinase 3)

Total number of chains: 2
Active chains: 2
Uniprot: MP2K3_HUMAN
Kinase Domain Residues: 64 - 325
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P46734-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K3 AF-P46734-K1A P46734 56 333 347.0 No_ligand No_ligand Active DFGin 6.1397 13.5458 BLAminus -145.76, 178.54 61.59, 68.14 -87.24, 10.44 309.02, 111.54 -66.26, -18.65 in-na in 7.5351 Saltbr-na 2.6701 HRD-in -75.88, -43.67 68.28, 5.0 na-in-in SNCaii in-in ActLoopNT-in 2.8724 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -73.88, 154.34 APE9-dihe-na 89.45, 170.23 APE8-dihe-in -78.17, 118.36 APE8-rot-na 198.27 APE67-dihe-in -66.34, -22.95 -48.99, -44.42 APE12-dist-in 12.7257 APE11-dist-in 10.5239 APE10-dist-in 5.429 APE9-dist-in 3.4055 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[64, 325]] 1.0 AF-P46734-K1 STE_MAP2K3_HUMAN STE 4.4e-85 291.1 3.0 257.0 255.0 207 208 209 211 213 93 110 114 187 189 188 190.0 250 234 229 228 227 226 225 224 223 141 Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3 AF-P46734-K3A P46734 56 333 347.0 No_ligand No_ligand Active DFGin 5.8823 13.2188 BLAminus -147.94, -177.7 61.33, 64.58 -84.29, 4.15 306.66, 110.61 -62.81, -14.99 in-na in 7.7593 Saltbr-na 2.7009 HRD-in -75.89, -41.74 68.62, -4.86 na-in-in SNCaii in-in ActLoopNT-in 2.8806 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -108.71, 131.9 APE9-dihe-na 114.74, 163.05 APE8-dihe-in -75.07, 111.88 APE8-rot-na 195.58 APE67-dihe-in -62.56, -26.04 -43.45, -44.98 APE12-dist-in 12.7703 APE11-dist-in 10.6268 APE10-dist-in 5.3908 APE9-dist-in 3.5296 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[64, 325]] 1.0 AF-P46734-K3 STE_MAP2K3_HUMAN STE 4.4e-85 291.1 3.0 257.0 255.0 207 208 209 211 213 93 110 114 187 189 188 190.0 250 234 229 228 227 226 225 224 223 141 Dual specificity mitogen-activated protein kinase kinase 3

STE_MAP2K3 (Dual specificity mitogen-activated protein kinase kinase 3)

Total number of chains: 2
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P46734-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP2K3 MP2K3_HUMAN AF-P46734-K1A P46734 56 333 347.0 No_ligand No_ligand Active DFGin 6.1397 13.5458 BLAminus -145.76, 178.54 61.59, 68.14 -87.24, 10.44 309.02, 111.54 -66.26, -18.65 in-na in 7.5351 Saltbr-na 2.6701 HRD-in -75.88, -43.67 68.28, 5.0 na-in-in SNCaii in-in ActLoopNT-in 2.8724 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -73.88, 154.34 APE9-dihe-na 89.45, 170.23 APE8-dihe-in -78.17, 118.36 APE8-rot-na 198.27 APE67-dihe-in -66.34, -22.95 -48.99, -44.42 APE12-dist-in 12.7257 APE11-dist-in 10.5239 APE10-dist-in 5.429 APE9-dist-in 3.4055 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[64, 325]] 1.0 AF-P46734-K1 Homo sapiens STE_MAP2K3_HUMAN STE 4.4e-85 291.1 3.0 257.0 255.0 207 208 209 211 213 93 110 114 187 189 188 190.0 250 234 229 228 227 226 225 224 223 141 Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3 MP2K3_HUMAN AF-P46734-K3A P46734 56 333 347.0 No_ligand No_ligand Active DFGin 5.8823 13.2188 BLAminus -147.94, -177.7 61.33, 64.58 -84.29, 4.15 306.66, 110.61 -62.81, -14.99 in-na in 7.7593 Saltbr-na 2.7009 HRD-in -75.89, -41.74 68.62, -4.86 na-in-in SNCaii in-in ActLoopNT-in 2.8806 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -108.71, 131.9 APE9-dihe-na 114.74, 163.05 APE8-dihe-in -75.07, 111.88 APE8-rot-na 195.58 APE67-dihe-in -62.56, -26.04 -43.45, -44.98 APE12-dist-in 12.7703 APE11-dist-in 10.6268 APE10-dist-in 5.3908 APE9-dist-in 3.5296 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 27 27 0 [[64, 325]] 1.0 AF-P46734-K3 Homo sapiens STE_MAP2K3_HUMAN STE 4.4e-85 291.1 3.0 257.0 255.0 207 208 209 211 213 93 110 114 187 189 188 190.0 250 234 229 228 227 226 225 224 223 141 Dual specificity mitogen-activated protein kinase kinase 3

STE_MAP2K3 (Dual specificity mitogen-activated protein kinase kinase 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name