TYR_JAK1-1 (Tyrosine-protein kinase JAK1)

Total number of chains: 4
Active chains: 0
Uniprot: JAK1_HUMAN
Kinase Domain Residues: 583 - 847
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 100.0% 4L00B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK1-1 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.7918 12.0795 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.5433 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.9539 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.3413 APE11-dist-na 11.7555 APE10-dist-na 15.957 APE9-dist-out 11.1256 V658F None None XRAY 1.9 0.204 0.233 A 304.0 274.0 12 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.8232 11.8723 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.8926 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.2987 APE11-dist-na 11.6951 APE10-dist-na 15.8459 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304.0 274.0 11 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.9117 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.5606 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.9607 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.4963 APE11-dist-na 11.8801 APE10-dist-na 16.1265 APE9-dist-out 11.1634 None None None XRAY 1.8 0.171 0.203 A 304.0 277.0 10 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.8723 11.9738 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.9735 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.3701 APE11-dist-na 11.8496 APE10-dist-na 15.9108 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304.0 278.0 8 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1

TYR_JAK1-1 (Tyrosine-protein kinase JAK1)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 100.0% 4L00B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK1-1 JAK1_HUMAN 4L01A P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.7918 12.0795 None -73.75, -179.09 -73.9, 162.14 -73.89, -15.61 344.71, 28.42 67.96, -153.13 in-na in 9.5433 Saltbr-na 999.0 HRD-in -87.9, -71.89 94.16, -0.24 na-out-out SNCaoo out-out ActLoopNT-out 7.9539 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.86, -39.57 APE9-dihe-out -58.05, -29.58 APE8-dihe-out -81.67, -7.08 APE8-rot-na 199.85 APE67-dihe-out -101.51, 19.28 -61.73, 134.72 APE12-dist-na 9.3413 APE11-dist-na 11.7555 APE10-dist-na 15.957 APE9-dist-out 11.1256 V658F None None XRAY 1.9 0.204 0.233 A 304.0 274.0 12 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 JAK1_HUMAN 4L01B P23458 565 849 1154.0 No_ligand No_ligand Pseudo DFGin 6.8232 11.8723 None -76.74, -176.42 -72.49, 166.45 -77.53, -11.38 359.0, 15.1 69.24, -153.25 in-na in 8.8926 Saltbr-na 999.0 HRD-in -86.59, -73.54 93.9, -0.47 na-out-out SNCaoo out-out ActLoopNT-out 8.016 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -57.69, -39.64 APE9-dihe-out -57.55, -28.87 APE8-dihe-out -85.94, -3.15 APE8-rot-na 200.27 APE67-dihe-out -99.61, 21.88 -63.69, 136.29 APE12-dist-na 9.2987 APE11-dist-na 11.6951 APE10-dist-na 15.8459 APE9-dist-out 11.03 V658F None None XRAY 1.9 0.204 0.233 B 304.0 274.0 11 24 24 0 [[583, 847], [875, 1151]] 2.0 4l01 Homo sapiens TYR_JAK1-1_HUMAN TYR 9.9e-61 211.3 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 JAK1_HUMAN 4L00A P23458 564 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.9117 11.988 None -76.07, -177.45 -75.3, 165.45 -78.74, -7.85 349.06, 24.36 63.89, -153.3 in-na in 9.5606 Saltbr-na 999.0 HRD-in -93.36, -71.42 93.51, 0.78 na-out-out SNCaoo out-out ActLoopNT-out 7.9607 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -60.21, -40.39 APE9-dihe-out -55.79, -30.01 APE8-dihe-out -85.56, 0.43 APE8-rot-na 187.12 APE67-dihe-out -101.03, 20.07 -69.52, 138.76 APE12-dist-na 9.4963 APE11-dist-na 11.8801 APE10-dist-na 16.1265 APE9-dist-out 11.1634 None None None XRAY 1.8 0.171 0.203 A 304.0 277.0 10 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1
JAK1-1 JAK1_HUMAN 4L00B P23458 565 850 1154.0 No_ligand No_ligand Pseudo DFGin 6.8723 11.9738 None -78.39, -173.09 -77.68, 164.49 -74.46, -8.56 347.77, 22.41 63.58, -153.63 in-na in 8.9735 Saltbr-na 999.0 HRD-in -90.15, -72.75 94.75, 3.66 na-out-out SNCaoo out-out ActLoopNT-out 7.929 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.66, -39.95 APE9-dihe-out -56.84, -31.4 APE8-dihe-out -81.07, -3.08 APE8-rot-na 200.04 APE67-dihe-out -104.62, 20.8 -63.46, 134.32 APE12-dist-na 9.3701 APE11-dist-na 11.8496 APE10-dist-na 15.9108 APE9-dist-out 11.081 None None None XRAY 1.8 0.171 0.203 B 304.0 278.0 8 24 24 0 [[583, 847], [875, 1151]] 2.0 4l00 Homo sapiens TYR_JAK1-1_HUMAN TYR 5.2e-61 212.2 2.0 260.0 259.0 738 739 740 742 744 622 638 642 711 713 712 714.0 775 762 757 756 755 754 753 752 751 668 Tyrosine-protein kinase JAK1

TYR_JAK1-1 (Tyrosine-protein kinase JAK1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name