CMGC_HIPK3 (Homeodomain-interacting protein kinase 3)

Total number of chains: 4
Active chains: 2
Uniprot: HIPK3_HUMAN
Kinase Domain Residues: 197 - 525
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% AF-Q9H422-K1A
DFGin ABAminus 1 25.0% 7O7JA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9H422-K1A 189 533 1215.0 No_ligand No_ligand Active DFGin 7.487 14.041 BLAminus -125.77, 176.15 61.94, 65.98 -75.37, 19.77 293.02, 92.39 -65.47, -27.21 in-in in 8.668 Saltbr-in 2.687 HRD-in -71.68, -44.73 63.82, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.24, 170.51 APE9-dihe-na 62.88, 149.25 APE8-dihe-in -66.73, 137.77 APE8-rot-in 294.87 APE67-dihe-in -67.11, -20.38 -54.57, -41.77 APE12-dist-in 10.319 APE11-dist-in 11.232 APE10-dist-in 7.388 APE9-dist-in 3.099 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[197, 525]] 1.0 AF-Q9H422-K1 CMGC_HIPK3_HUMAN CMGC 9e-92 313.4 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
AF-Q9H422-K3A 189 533 1215.0 No_ligand No_ligand Active DFGin 7.23 13.911 BLAminus -130.4, 177.71 58.91, 63.77 -70.14, 17.77 295.94, 97.42 -66.3, -25.05 in-in in 8.666 Saltbr-in 2.713 HRD-in -73.64, -43.92 65.7, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.88, 161.33 APE9-dihe-na 61.68, 144.54 APE8-dihe-in -63.24, 138.57 APE8-rot-in 290.89 APE67-dihe-in -61.08, -16.33 -48.36, -60.09 APE12-dist-in 10.221 APE11-dist-in 11.052 APE10-dist-in 7.545 APE9-dist-in 3.238 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[197, 525]] 1.0 AF-Q9H422-K3 CMGC_HIPK3_HUMAN CMGC 9e-92 313.4 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
7O7JA 184 551 1215.0 6ZV:900 Type1 Inactive DFGin 6.769 12.814 ABAminus -150.57, 19.86 -126.49, 140.14 -135.48, -1.44 295.28, 99.99 -58.01, -8.59 in-in in 9.192 Saltbr-in 3.33 HRD-in -71.19, -60.02 89.21, -9.2 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -150.61, 30.48 APE9-dihe-na -155.74, 169.72 APE8-dihe-in -79.02, 130.55 APE8-rot-out 217.49 APE67-dihe-in -54.17, -15.73 -52.69, -52.23 APE12-dist-in 11.969 APE11-dist-in 10.888 APE10-dist-in 6.751 APE9-dist-in 3.571 None PTR359 PTR359 XRAY 2.81 0.247 0.273 A 404 368 0 0 0 0 [[197, 525]] 1.0 7o7j CMGC_HIPK3_HUMAN CMGC 1.6e-91 312.7 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
7O7IA 184 550 1215.0 No_ligand No_ligand Inactive DFGin 7.114 13.483 BLAminus -128.23, -178.45 62.59, 77.66 -92.85, 15.22 293.07, 86.84 -63.42, -10.5 in-in in 8.97 Saltbr-in 2.536 HRD-in -80.89, -42.96 62.27, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.94, -84.91 APE9-dihe-na -64.45, 175.75 APE8-dihe-in -66.17, 147.74 APE8-rot-out 195.44 APE67-dihe-in -63.88, -21.95 -63.83, -47.27 APE12-dist-in 13.708 APE11-dist-in 11.875 APE10-dist-in 7.864 APE9-dist-in 3.382 None PTR359 PTR359 XRAY 2.5 0.246 0.275 A 404 367 0 0 0 0 [[197, 525]] 1.0 7o7i CMGC_HIPK3_HUMAN CMGC 1.6e-91 312.7 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3

CMGC_HIPK3 (Homeodomain-interacting protein kinase 3)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% AF-Q9H422-K1A
DFGin ABAminus 1 25.0% 7O7JA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
HIPK3_HUMAN AF-Q9H422-K1A Q9H422 189 533 1215.0 No_ligand No_ligand Active DFGin 7.487 14.041 BLAminus -125.77, 176.15 61.94, 65.98 -75.37, 19.77 293.02, 92.39 -65.47, -27.21 in-in in 8.668 Saltbr-in 2.687 HRD-in -71.68, -44.73 63.82, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.24, 170.51 APE9-dihe-na 62.88, 149.25 APE8-dihe-in -66.73, 137.77 APE8-rot-in 294.87 APE67-dihe-in -67.11, -20.38 -54.57, -41.77 APE12-dist-in 10.319 APE11-dist-in 11.232 APE10-dist-in 7.388 APE9-dist-in 3.099 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[197, 525]] 1.0 AF-Q9H422-K1 Homo sapiens CMGC_HIPK3_HUMAN CMGC 9e-92 313.4 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
HIPK3_HUMAN AF-Q9H422-K3A Q9H422 189 533 1215.0 No_ligand No_ligand Active DFGin 7.23 13.911 BLAminus -130.4, 177.71 58.91, 63.77 -70.14, 17.77 295.94, 97.42 -66.3, -25.05 in-in in 8.666 Saltbr-in 2.713 HRD-in -73.64, -43.92 65.7, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.88, 161.33 APE9-dihe-na 61.68, 144.54 APE8-dihe-in -63.24, 138.57 APE8-rot-in 290.89 APE67-dihe-in -61.08, -16.33 -48.36, -60.09 APE12-dist-in 10.221 APE11-dist-in 11.052 APE10-dist-in 7.545 APE9-dist-in 3.238 None None None AF2 -1.0 1.0 1.0 A 345 345 0 0 0 0 [[197, 525]] 1.0 AF-Q9H422-K3 Homo sapiens CMGC_HIPK3_HUMAN CMGC 9e-92 313.4 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
HIPK3_HUMAN 7O7JA Q9H422 184 551 1215.0 6ZV:900 Type1 Inactive DFGin 6.769 12.814 ABAminus -150.57, 19.86 -126.49, 140.14 -135.48, -1.44 295.28, 99.99 -58.01, -8.59 in-in in 9.192 Saltbr-in 3.33 HRD-in -71.19, -60.02 89.21, -9.2 in-in-out SNCiio in-out ActLoopNT-in 3.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -150.61, 30.48 APE9-dihe-na -155.74, 169.72 APE8-dihe-in -79.02, 130.55 APE8-rot-out 217.49 APE67-dihe-in -54.17, -15.73 -52.69, -52.23 APE12-dist-in 11.969 APE11-dist-in 10.888 APE10-dist-in 6.751 APE9-dist-in 3.571 None PTR359 PTR359 XRAY 2.81 0.247 0.273 A 404 368 0 0 0 0 [[197, 525]] 1.0 7o7j Homo sapiens CMGC_HIPK3_HUMAN CMGC 1.6e-91 312.7 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3
HIPK3_HUMAN 7O7IA Q9H422 184 550 1215.0 No_ligand No_ligand Inactive DFGin 7.114 13.483 BLAminus -128.23, -178.45 62.59, 77.66 -92.85, 15.22 293.07, 86.84 -63.42, -10.5 in-in in 8.97 Saltbr-in 2.536 HRD-in -80.89, -42.96 62.27, 14.44 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -138.94, -84.91 APE9-dihe-na -64.45, 175.75 APE8-dihe-in -66.17, 147.74 APE8-rot-out 195.44 APE67-dihe-in -63.88, -21.95 -63.83, -47.27 APE12-dist-in 13.708 APE11-dist-in 11.875 APE10-dist-in 7.864 APE9-dist-in 3.382 None PTR359 PTR359 XRAY 2.5 0.246 0.275 A 404 367 0 0 0 0 [[197, 525]] 1.0 7o7i Homo sapiens CMGC_HIPK3_HUMAN CMGC 1.6e-91 312.7 1 301 301 343 344 345 347 349 226 241 245 319 321 320 322 381 369 364 363 362 361 360 359 358 276 Homeodomain-interacting protein kinase 3

CMGC_HIPK3 (Homeodomain-interacting protein kinase 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name