CAMK_GCN2 (eIF-2-alpha kinase GCN2)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name

CAMK_GCN2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 16 88.9% 1ZXEC
None None 2 11.1% 9F58A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GCN2_YEAST 9F58A P15442 206 527 1659.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.1 0.285 999.0 A 1659 322 0 0 0 0 [[292, 527], [599, 981]] 2.0 9f58 Saccharomyces cerevisiae CAMK_GCN2-1_YEAST CAMK 3.3e-10 209.4 39 251 500 852 853 854 856 858 628 758 762 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 9F58C P15442 594 978 1659.0 No_ligand No_ligand Inactive None 999.0 14.86 None -153.62, -178.92 52.27, 68.71 -64.57, 153.09 287.38, 72.42 -79.76, 63.95 none-none none 999.0 Saltbr-none 999.0 HRD-in -74.65, -44.74 79.34, -34.92 none-out-out SNCnoo out-out ActLoopNT-out 9.643 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.23, -43.8 APE9-dihe-na -57.02, -42.12 APE8-dihe-out -71.25, -37.36 APE8-rot-in 298.65 APE67-dihe-in -73.54, -26.81 -68.51, -12.19 APE12-dist-out 18.94 APE11-dist-out 17.973 APE10-dist-out 21.441 APE9-dist-out 12.834 None None None EM 3.1 0.285 999.0 C 1659 259 129 0 0 11 [[292, 527], [599, 981]] 2.0 9f58 Saccharomyces cerevisiae CAMK_GCN2-2_YEAST CAMK 3.3e-10 209.4 39 251 500 852 853 854 856 858 628 758 762 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.436 13.948 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.661 Saltbr-out 11.057 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.502 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.603 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.825 Saltbr-out 9.799 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.754 R794G None None XRAY 2.0 0.235 0.279 B 303 247 40 0 0 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.41 14.106 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.801 Saltbr-out 11.502 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.833 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.094 None None None XRAY 2.75 0.208 0.27 A 303 268 32 0 0 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.558 14.184 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.647 Saltbr-out 11.162 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.788 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303 251 36 0 0 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY4A P15442 594 996 1659.0 No_ligand No_ligand Inactive DFGin 6.491 14.097 BLBminus -141.2, -168.71 50.41, 53.15 -56.12, 143.03 285.1, 70.54 -79.15, 125.91 out-out out 12.51 Saltbr-out 10.784 HRD-in -68.18, -49.57 79.73, -18.97 out-out-none SNCoon out-none ActLoopNT-out 8.528 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.13, -21.97 999.0, -50.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 1.95 0.224 0.252 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy4 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY4B P15442 594 983 1659.0 No_ligand No_ligand Inactive DFGin 6.671 13.911 BLBminus -136.37, -167.89 43.68, 56.87 -54.78, 149.56 283.72, 66.61 -91.38, 122.84 out-out out 12.619 Saltbr-out 10.316 HRD-in -71.84, -50.38 77.58, -14.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 113.27 APE9-dihe-na 109.31, -50.65 APE8-dihe-out -87.68, -28.39 APE8-rot-out 178.05 APE67-dihe-in -65.74, -33.72 -57.79, -23.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.391 APE9-dist-out 11.943 R794G None None XRAY 1.95 0.224 0.252 B 303 247 40 0 0 28 [[292, 527], [599, 981]] 2.0 1zy4 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCA P15442 594 989 1659.0 No_ligand No_ligand Inactive DFGin 6.79 13.778 BLBminus -131.7, -171.67 47.61, 66.73 -71.22, 151.39 283.38, 67.64 -92.99, 59.26 out-out out 12.721 Saltbr-out 11.448 HRD-in -61.12, -52.58 78.37, -10.71 out-out-out SNCooo out-out ActLoopNT-out 8.873 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 163.15 APE9-dihe-na 169.01, -31.7 APE8-dihe-out -64.24, -42.14 APE8-rot-in 320.94 APE67-dihe-in -60.78, -34.66 -75.99, -5.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.299 APE9-dist-out 12.538 None None None XRAY 3.0 0.234 0.299 A 303 259 34 0 0 25 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCB P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.286 13.84 BLBminus -128.3, 178.61 53.63, 71.1 -67.59, 146.84 289.82, 65.34 -75.2, 122.9 out-out out 12.852 Saltbr-out 8.902 HRD-in -62.83, -58.71 82.99, 2.24 out-out-out SNCooo out-out ActLoopNT-out 9.45 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.12 APE8-dihe-out -124.2, -2.55 APE8-rot-out 44.97 APE67-dihe-in -75.72, -16.29 -90.7, 5.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 None None None XRAY 3.0 0.234 0.299 B 303 252 36 0 0 25 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCC P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.442 13.706 BLBminus -164.97, -173.6 69.91, 38.41 -55.84, 134.83 280.23, 73.01 -81.91, 98.97 out-out out 12.592 Saltbr-out 10.781 HRD-in -70.78, -55.63 77.67, -5.04 out-out-out SNCooo out-out ActLoopNT-out 8.202 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 151.36 APE9-dihe-na -129.88, -43.57 APE8-dihe-out -62.46, -13.29 APE8-rot-in 301.73 APE67-dihe-in -63.88, -15.68 -54.56, -44.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.623 APE9-dist-out 11.627 None None None XRAY 3.0 0.234 0.299 C 303 269 30 0 0 24 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCD P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.415 14.103 BLBminus -142.95, 175.22 76.84, 37.68 -54.42, 130.1 304.7, 74.41 -74.91, 124.96 out-out out 12.473 Saltbr-out 10.389 HRD-in -68.74, -41.54 67.58, 6.01 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 116.72 APE9-dihe-na -105.19, -3.34 APE8-dihe-out -77.61, -14.62 APE8-rot-in 292.44 APE67-dihe-in -78.43, -12.4 -66.46, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.283 APE9-dist-out 13.181 None None None XRAY 3.0 0.234 0.299 D 303 254 34 0 0 24 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEA P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.731 13.991 BLBminus -135.69, -163.98 52.63, 47.23 -57.26, 148.51 284.51, 67.67 -90.84, 106.35 out-out out 12.802 Saltbr-out 11.043 HRD-in -60.87, -54.83 82.07, -8.69 out-out-out SNCooo out-out ActLoopNT-out 8.314 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -122.65, 72.87 APE9-dihe-na -78.52, 1.43 APE8-dihe-out -74.81, -37.5 APE8-rot-in 311.83 APE67-dihe-in -66.15, -28.76 -73.04, -8.0 APE12-dist-none 999.0 APE11-dist-out 23.068 APE10-dist-out 19.168 APE9-dist-out 13.201 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 A 303 267 32 0 0 24 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEB P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.578 14.343 BLBminus -133.64, -171.27 59.44, 48.41 -57.18, 145.55 282.87, 71.2 -81.95, 122.89 out-out out 12.57 Saltbr-out 10.759 HRD-in -66.25, -50.56 74.49, -7.9 out-out-out SNCooo out-out ActLoopNT-out 8.443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.15 APE8-dihe-in -81.18, 56.78 APE8-rot-in 305.81 APE67-dihe-in -65.95, -22.86 -104.17, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.819 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 B 303 250 38 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEC P15442 594 996 1659.0 No_ligand No_ligand Inactive DFGin 6.631 14.005 BLBminus -140.81, -170.61 61.82, 52.71 -63.46, 141.24 284.51, 68.02 -80.44, 128.18 out-out out 12.6 Saltbr-out 10.843 HRD-in -63.6, -54.02 76.44, -4.27 out-out-out SNCooo out-out ActLoopNT-out 8.567 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -79.68, -1.91 APE9-dihe-na -69.9, -28.44 APE8-dihe-out -60.52, -37.01 APE8-rot-in 269.18 APE67-dihe-in -63.46, -18.24 -66.48, -21.41 APE12-dist-out 22.948 APE11-dist-out 17.53 APE10-dist-out 19.92 APE9-dist-out 13.091 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 C 303 273 27 0 0 21 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXED P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.475 14.239 BLBminus -132.88, -166.48 55.17, 49.6 -57.94, 149.72 283.03, 71.97 -88.33, 117.34 out-out out 12.63 Saltbr-out 10.825 HRD-in -66.09, -51.22 73.99, -11.55 out-out-out SNCooo out-out ActLoopNT-out 8.511 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -9.91 APE8-dihe-out -129.05, -15.97 APE8-rot-in 296.94 APE67-dihe-in -63.08, -28.52 -75.45, -13.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.531 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 D 303 254 34 0 0 24 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEE P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.835 14.042 BLBminus -136.07, -176.85 59.72, 59.59 -68.51, 145.74 288.07, 60.68 -79.17, 136.46 out-out out 12.853 Saltbr-out 11.074 HRD-in -67.5, -51.12 66.29, 10.84 out-out-out SNCooo out-out ActLoopNT-out 9.43 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.17 APE8-dihe-out -157.73, -16.58 APE8-rot-out 179.72 APE67-dihe-in -76.27, -21.96 -88.03, 36.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.562 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 E 303 262 37 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEF P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.83 14.492 BLBminus -147.27, -170.16 47.23, 63.77 -67.31, 146.65 282.2, 63.95 -73.34, 124.35 out-out out 12.547 Saltbr-out 13.274 HRD-in -61.07, -55.66 80.12, -5.22 out-out-out SNCooo out-out ActLoopNT-out 8.793 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -49.66 APE9-dihe-na -99.84, -38.0 APE8-dihe-out -81.29, -15.23 APE8-rot-out 176.44 APE67-dihe-in -62.3, -21.2 -74.4, -15.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.637 APE9-dist-out 13.386 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 F 303 247 41 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2

CAMK_GCN2 (eIF-2-alpha kinase GCN2)

Total number of chains: 18
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 16 88.9% 1ZXEC
None None 2 11.1% 9F58A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GCN2_YEAST 9F58A P15442 206 527 1659.0 No_ligand No_ligand Inactive None 999.0 999.0 None 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-none 999.0, 999.0 999.0, 999.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.1 0.285 999.0 A 1659 322 0 0 0 0 [[292, 527], [599, 981]] 2.0 9f58 Saccharomyces cerevisiae CAMK_GCN2-1_YEAST CAMK 3.3e-10 209.4 39 251 500 852 853 854 856 858 628 758 762 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 9F58C P15442 594 978 1659.0 No_ligand No_ligand Inactive None 999.0 14.86 None -153.62, -178.92 52.27, 68.71 -64.57, 153.09 287.38, 72.42 -79.76, 63.95 none-none none 999.0 Saltbr-none 999.0 HRD-in -74.65, -44.74 79.34, -34.92 none-out-out SNCnoo out-out ActLoopNT-out 9.643 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -57.23, -43.8 APE9-dihe-na -57.02, -42.12 APE8-dihe-out -71.25, -37.36 APE8-rot-in 298.65 APE67-dihe-in -73.54, -26.81 -68.51, -12.19 APE12-dist-out 18.94 APE11-dist-out 17.973 APE10-dist-out 21.441 APE9-dist-out 12.834 None None None EM 3.1 0.285 999.0 C 1659 259 129 0 0 11 [[292, 527], [599, 981]] 2.0 9f58 Saccharomyces cerevisiae CAMK_GCN2-2_YEAST CAMK 3.3e-10 209.4 39 251 500 852 853 854 856 858 628 758 762 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.436 13.948 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.661 Saltbr-out 11.057 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.502 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.603 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.825 Saltbr-out 9.799 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.754 R794G None None XRAY 2.0 0.235 0.279 B 303 247 40 0 0 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.41 14.106 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.801 Saltbr-out 11.502 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.833 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.094 None None None XRAY 2.75 0.208 0.27 A 303 268 32 0 0 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.558 14.184 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.647 Saltbr-out 11.162 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.788 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303 251 36 0 0 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY4A P15442 594 996 1659.0 No_ligand No_ligand Inactive DFGin 6.491 14.097 BLBminus -141.2, -168.71 50.41, 53.15 -56.12, 143.03 285.1, 70.54 -79.15, 125.91 out-out out 12.51 Saltbr-out 10.784 HRD-in -68.18, -49.57 79.73, -18.97 out-out-none SNCoon out-none ActLoopNT-out 8.528 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.13, -21.97 999.0, -50.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 1.95 0.224 0.252 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy4 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZY4B P15442 594 983 1659.0 No_ligand No_ligand Inactive DFGin 6.671 13.911 BLBminus -136.37, -167.89 43.68, 56.87 -54.78, 149.56 283.72, 66.61 -91.38, 122.84 out-out out 12.619 Saltbr-out 10.316 HRD-in -71.84, -50.38 77.58, -14.2 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 113.27 APE9-dihe-na 109.31, -50.65 APE8-dihe-out -87.68, -28.39 APE8-rot-out 178.05 APE67-dihe-in -65.74, -33.72 -57.79, -23.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.391 APE9-dist-out 11.943 R794G None None XRAY 1.95 0.224 0.252 B 303 247 40 0 0 28 [[292, 527], [599, 981]] 2.0 1zy4 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCA P15442 594 989 1659.0 No_ligand No_ligand Inactive DFGin 6.79 13.778 BLBminus -131.7, -171.67 47.61, 66.73 -71.22, 151.39 283.38, 67.64 -92.99, 59.26 out-out out 12.721 Saltbr-out 11.448 HRD-in -61.12, -52.58 78.37, -10.71 out-out-out SNCooo out-out ActLoopNT-out 8.873 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 163.15 APE9-dihe-na 169.01, -31.7 APE8-dihe-out -64.24, -42.14 APE8-rot-in 320.94 APE67-dihe-in -60.78, -34.66 -75.99, -5.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.299 APE9-dist-out 12.538 None None None XRAY 3.0 0.234 0.299 A 303 259 34 0 0 25 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCB P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.286 13.84 BLBminus -128.3, 178.61 53.63, 71.1 -67.59, 146.84 289.82, 65.34 -75.2, 122.9 out-out out 12.852 Saltbr-out 8.902 HRD-in -62.83, -58.71 82.99, 2.24 out-out-out SNCooo out-out ActLoopNT-out 9.45 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.12 APE8-dihe-out -124.2, -2.55 APE8-rot-out 44.97 APE67-dihe-in -75.72, -16.29 -90.7, 5.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 None None None XRAY 3.0 0.234 0.299 B 303 252 36 0 0 25 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCC P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.442 13.706 BLBminus -164.97, -173.6 69.91, 38.41 -55.84, 134.83 280.23, 73.01 -81.91, 98.97 out-out out 12.592 Saltbr-out 10.781 HRD-in -70.78, -55.63 77.67, -5.04 out-out-out SNCooo out-out ActLoopNT-out 8.202 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 151.36 APE9-dihe-na -129.88, -43.57 APE8-dihe-out -62.46, -13.29 APE8-rot-in 301.73 APE67-dihe-in -63.88, -15.68 -54.56, -44.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.623 APE9-dist-out 11.627 None None None XRAY 3.0 0.234 0.299 C 303 269 30 0 0 24 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZYCD P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.415 14.103 BLBminus -142.95, 175.22 76.84, 37.68 -54.42, 130.1 304.7, 74.41 -74.91, 124.96 out-out out 12.473 Saltbr-out 10.389 HRD-in -68.74, -41.54 67.58, 6.01 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 116.72 APE9-dihe-na -105.19, -3.34 APE8-dihe-out -77.61, -14.62 APE8-rot-in 292.44 APE67-dihe-in -78.43, -12.4 -66.46, -9.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.283 APE9-dist-out 13.181 None None None XRAY 3.0 0.234 0.299 D 303 254 34 0 0 24 [[292, 527], [599, 981]] 2.0 1zyc Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEA P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.731 13.991 BLBminus -135.69, -163.98 52.63, 47.23 -57.26, 148.51 284.51, 67.67 -90.84, 106.35 out-out out 12.802 Saltbr-out 11.043 HRD-in -60.87, -54.83 82.07, -8.69 out-out-out SNCooo out-out ActLoopNT-out 8.314 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -122.65, 72.87 APE9-dihe-na -78.52, 1.43 APE8-dihe-out -74.81, -37.5 APE8-rot-in 311.83 APE67-dihe-in -66.15, -28.76 -73.04, -8.0 APE12-dist-none 999.0 APE11-dist-out 23.068 APE10-dist-out 19.168 APE9-dist-out 13.201 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 A 303 267 32 0 0 24 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEB P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.578 14.343 BLBminus -133.64, -171.27 59.44, 48.41 -57.18, 145.55 282.87, 71.2 -81.95, 122.89 out-out out 12.57 Saltbr-out 10.759 HRD-in -66.25, -50.56 74.49, -7.9 out-out-out SNCooo out-out ActLoopNT-out 8.443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.15 APE8-dihe-in -81.18, 56.78 APE8-rot-in 305.81 APE67-dihe-in -65.95, -22.86 -104.17, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.819 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 B 303 250 38 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEC P15442 594 996 1659.0 No_ligand No_ligand Inactive DFGin 6.631 14.005 BLBminus -140.81, -170.61 61.82, 52.71 -63.46, 141.24 284.51, 68.02 -80.44, 128.18 out-out out 12.6 Saltbr-out 10.843 HRD-in -63.6, -54.02 76.44, -4.27 out-out-out SNCooo out-out ActLoopNT-out 8.567 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -79.68, -1.91 APE9-dihe-na -69.9, -28.44 APE8-dihe-out -60.52, -37.01 APE8-rot-in 269.18 APE67-dihe-in -63.46, -18.24 -66.48, -21.41 APE12-dist-out 22.948 APE11-dist-out 17.53 APE10-dist-out 19.92 APE9-dist-out 13.091 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 C 303 273 27 0 0 21 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXED P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.475 14.239 BLBminus -132.88, -166.48 55.17, 49.6 -57.94, 149.72 283.03, 71.97 -88.33, 117.34 out-out out 12.63 Saltbr-out 10.825 HRD-in -66.09, -51.22 73.99, -11.55 out-out-out SNCooo out-out ActLoopNT-out 8.511 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -9.91 APE8-dihe-out -129.05, -15.97 APE8-rot-in 296.94 APE67-dihe-in -63.08, -28.52 -75.45, -13.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.531 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 D 303 254 34 0 0 24 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEE P15442 594 995 1659.0 No_ligand No_ligand Inactive DFGin 6.835 14.042 BLBminus -136.07, -176.85 59.72, 59.59 -68.51, 145.74 288.07, 60.68 -79.17, 136.46 out-out out 12.853 Saltbr-out 11.074 HRD-in -67.5, -51.12 66.29, 10.84 out-out-out SNCooo out-out ActLoopNT-out 9.43 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 26.17 APE8-dihe-out -157.73, -16.58 APE8-rot-out 179.72 APE67-dihe-in -76.27, -21.96 -88.03, 36.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.562 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 E 303 262 37 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
GCN2_YEAST 1ZXEF P15442 594 984 1659.0 No_ligand No_ligand Inactive DFGin 6.83 14.492 BLBminus -147.27, -170.16 47.23, 63.77 -67.31, 146.65 282.2, 63.95 -73.34, 124.35 out-out out 12.547 Saltbr-out 13.274 HRD-in -61.07, -55.66 80.12, -5.22 out-out-out SNCooo out-out ActLoopNT-out 8.793 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -49.66 APE9-dihe-na -99.84, -38.0 APE8-dihe-out -81.29, -15.23 APE8-rot-out 176.44 APE67-dihe-in -62.3, -21.2 -74.4, -15.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.637 APE9-dist-out 13.386 D835N None MSE645,MSE775,MSE788,MSE839,MSE889,MSE908,MSE918,MSE926,MSE951 XRAY 2.6 0.204 0.252 F 303 247 41 0 0 25 [[292, 527], [599, 981]] 2.0 1zxe Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 8.3e-44 160.8 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2