TYR_ERBB4 (Receptor tyrosine-protein kinase erbB-4)

Total number of chains: 11
Active chains: 2
Uniprot: ERBB4_HUMAN
Kinase Domain Residues: 718 - 976
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 54.5% 2R4BA
DFGin BLAminus 5 45.5% AF-Q15303-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERBB4 AF-Q15303-K1A Q15303 710 984 1308.0 No_ligand No_ligand Active DFGin 6.5155 13.7887 BLAminus -138.58, -178.06 63.23, 62.34 -82.1, 16.3 299.44, 94.38 -63.43, -22.7 in-in in 8.4406 Saltbr-in 2.7283 HRD-in -75.71, -42.14 68.03, -17.75 in-in-in SNCiii in-in ActLoopNT-in 2.8425 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.12, 129.58 APE9-dihe-in -120.85, 138.26 APE8-dihe-in -78.89, 66.42 APE8-rot-na 35.42 APE67-dihe-in -68.26, -13.31 -43.94, -39.74 APE12-dist-na 11.2579 APE11-dist-na 9.5857 APE10-dist-na 10.6702 APE9-dist-in 7.0097 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[718, 976]] 1.0 AF-Q15303-K1 TYR_ERBB4_HUMAN TYR 6.2e-92 313.5 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 AF-Q15303-K3A Q15303 710 984 1308.0 No_ligand No_ligand Active DFGin 6.1069 13.9606 BLAminus -144.12, -174.08 64.76, 67.05 -86.64, 13.15 303.01, 98.51 -61.55, -26.65 in-in in 8.7156 Saltbr-in 2.7394 HRD-in -75.89, -41.62 66.66, -9.65 in-in-in SNCiii in-in ActLoopNT-in 2.8599 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.55, 124.4 APE9-dihe-in -129.35, 153.9 APE8-dihe-in -79.47, 68.03 APE8-rot-na 37.65 APE67-dihe-in -68.69, -13.4 -46.24, -36.17 APE12-dist-na 11.499 APE11-dist-na 9.903 APE10-dist-na 10.7107 APE9-dist-in 6.4175 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[718, 976]] 1.0 AF-Q15303-K3 TYR_ERBB4_HUMAN TYR 6.2e-92 313.5 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BCEA Q15303 703 991 1308.0 No_ligand No_ligand Inactive DFGin 6.0916 14.4355 BLAminus -135.99, -161.87 58.5, 65.48 -92.84, 14.19 300.5, 106.96 -58.68, -27.31 in-in in 9.315 Saltbr-in 3.0193 HRD-in -68.09, -45.14 71.02, -10.91 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -126.43, 37.46 APE9-dihe-in -60.63, 140.48 APE8-dihe-in -70.41, 138.16 APE8-rot-na 25.54 APE67-dihe-in -73.08, -10.08 -65.38, -24.14 APE12-dist-na 999.0 APE11-dist-na 6.7444 APE10-dist-na 9.2015 APE9-dist-in 4.9388 None None None XRAY 2.5 0.198 0.251 A 328.0 285.0 4 30 28 2 [[718, 976]] 1.0 3bce TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BCEB Q15303 703 993 1308.0 No_ligand No_ligand Inactive DFGin 6.1958 14.43 BLAminus -142.17, -168.34 59.33, 68.86 -94.24, 18.37 306.31, 104.41 -53.43, -33.51 in-out in 9.3342 Saltbr-out 4.3001 HRD-in -56.3, -51.6 73.77, -8.26 out-in-in SNCoii in-in ActLoopNT-in 2.7951 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 63.14 APE9-dihe-in -67.59, 140.47 APE8-dihe-in -58.71, 139.03 APE8-rot-na 20.16 APE67-dihe-in -73.54, -5.61 -69.18, -26.8 APE12-dist-na 999.0 APE11-dist-na 6.5244 APE10-dist-na 9.3842 APE9-dist-in 4.8922 None None None XRAY 2.5 0.198 0.251 B 328.0 286.0 5 30 28 2 [[718, 976]] 1.0 3bce TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BCEC Q15303 703 990 1308.0 No_ligand No_ligand Inactive DFGin 6.2842 14.3357 BLAminus -139.34, -169.98 72.61, 58.98 -85.97, 21.67 314.92, 93.62 -53.56, -43.33 in-out in 9.3689 Saltbr-out 4.2744 HRD-in -67.32, -52.25 76.29, -9.03 out-in-in SNCoii in-in ActLoopNT-in 2.8843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.44, 67.91 APE9-dihe-in -67.32, 138.65 APE8-dihe-in -64.36, 136.49 APE8-rot-na 19.89 APE67-dihe-in -70.04, -7.66 -66.17, -25.36 APE12-dist-na 999.0 APE11-dist-na 6.5181 APE10-dist-na 9.3896 APE9-dist-in 4.7144 None None None XRAY 2.5 0.198 0.251 C 328.0 286.0 2 30 28 2 [[718, 976]] 1.0 3bce TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BBWA Q15303 708 991 1308.0 No_ligand No_ligand Inactive DFGin 6.0738 13.0734 BLBplus -127.54, 175.95 65.72, 20.39 -67.87, 137.16 37.62, 79.68 60.16, 23.67 out-out out 14.1039 Saltbr-out 15.0287 HRD-in -62.44, -52.25 83.05, -11.24 out-out-none SNCoon out-none ActLoopNT-out 7.0404 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 50.31 APE8-rot-na 26.37 APE67-dihe-in -69.72, -5.68 -66.64, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.305 0.354 A 328.0 268.0 16 30 16 14 [[718, 976]] 1.0 3bbw TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BBWB Q15303 708 998 1308.0 No_ligand No_ligand Inactive DFGin 6.1544 13.0578 BLBplus -125.64, 179.61 65.63, 18.58 -69.05, 136.5 35.98, 80.62 64.15, 18.09 out-out out 14.1625 Saltbr-out 15.058 HRD-in -62.94, -50.36 84.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 7.1027 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.42 APE8-rot-na 29.99 APE67-dihe-in -69.34, -5.46 -67.52, -43.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.305 0.354 B 328.0 275.0 16 30 16 14 [[718, 976]] 1.0 3bbw TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 2R4BA Q15303 694 991 1308.0 GW7:1 Type1.5_Back Inactive DFGin 4.8884 13.7643 BLBplus -131.45, 171.83 72.48, 18.96 -72.29, 139.7 46.29, 78.43 96.99, -38.5 out-out out 12.4712 Saltbr-out 12.4472 HRD-in -72.41, -53.35 83.43, -17.46 out-out-out SNCooo out-out ActLoopNT-out 6.626 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.99, -22.63 APE9-dihe-in -79.79, 147.87 APE8-dihe-in -66.33, 125.88 APE8-rot-na 22.44 APE67-dihe-in -72.84, -10.87 -47.99, -38.08 APE12-dist-na 16.1637 APE11-dist-na 12.7639 APE10-dist-na 9.1884 APE9-dist-in 5.4581 None None None XRAY 2.4 0.209 0.263 A 321.0 292.0 6 30 30 0 [[718, 976]] 1.0 2r4b TYR_ERBB4_HUMAN TYR 1.1e-91 312.8 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 2R4BB Q15303 694 991 1308.0 GW7:1 Type1.5_Back Inactive DFGin 4.9841 13.6997 BLBplus -129.8, 173.21 73.77, 11.79 -69.91, 143.8 45.64, 81.74 93.59, -37.44 out-out out 12.5298 Saltbr-out 12.2339 HRD-in -79.37, -52.03 82.87, -19.74 out-out-out SNCooo out-out ActLoopNT-out 6.5003 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.32, -24.68 APE9-dihe-in -77.32, 145.71 APE8-dihe-in -64.77, 128.36 APE8-rot-na 23.01 APE67-dihe-in -77.58, -10.73 -52.3, -32.59 APE12-dist-na 16.1561 APE11-dist-na 12.8936 APE10-dist-na 9.2532 APE9-dist-in 5.4477 None None None XRAY 2.4 0.209 0.263 B 321.0 291.0 7 30 30 0 [[718, 976]] 1.0 2r4b TYR_ERBB4_HUMAN TYR 1.1e-91 312.8 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BBTB Q15303 708 998 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.3878 13.2905 BLBplus -127.16, 173.3 66.25, 23.71 -69.76, 136.77 43.82, 86.88 52.5, 43.04 out-out out 14.0397 Saltbr-out 15.3219 HRD-in -81.46, -41.77 86.97, -19.99 out-out-none SNCoon out-none ActLoopNT-out 6.9601 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.83 APE8-rot-na 22.98 APE67-dihe-in -74.99, -6.22 -53.46, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 B 328.0 274.0 16 30 16 14 [[718, 976]] 1.0 3bbt TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 3BBTD Q15303 709 988 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.7877 13.6387 BLBplus -120.15, 168.79 64.17, 29.05 -72.9, 132.71 41.75, 86.79 49.44, 51.55 out-out out 14.4078 Saltbr-out 15.8396 HRD-in -78.17, -59.42 94.63, -3.9 out-out-none SNCoon out-none ActLoopNT-out 7.615 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 43.72 APE8-rot-na 29.87 APE67-dihe-in -73.55, -7.87 -60.37, -33.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 D 328.0 259.0 21 30 14 16 [[718, 976]] 1.0 3bbt TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4

TYR_ERBB4 (Receptor tyrosine-protein kinase erbB-4)

Total number of chains: 11
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 6 54.5% 2R4BA
DFGin BLAminus 5 45.5% AF-Q15303-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ERBB4 ERBB4_HUMAN AF-Q15303-K1A Q15303 710 984 1308.0 No_ligand No_ligand Active DFGin 6.5155 13.7887 BLAminus -138.58, -178.06 63.23, 62.34 -82.1, 16.3 299.44, 94.38 -63.43, -22.7 in-in in 8.4406 Saltbr-in 2.7283 HRD-in -75.71, -42.14 68.03, -17.75 in-in-in SNCiii in-in ActLoopNT-in 2.8425 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.12, 129.58 APE9-dihe-in -120.85, 138.26 APE8-dihe-in -78.89, 66.42 APE8-rot-na 35.42 APE67-dihe-in -68.26, -13.31 -43.94, -39.74 APE12-dist-na 11.2579 APE11-dist-na 9.5857 APE10-dist-na 10.6702 APE9-dist-in 7.0097 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[718, 976]] 1.0 AF-Q15303-K1 Homo sapiens TYR_ERBB4_HUMAN TYR 6.2e-92 313.5 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN AF-Q15303-K3A Q15303 710 984 1308.0 No_ligand No_ligand Active DFGin 6.1069 13.9606 BLAminus -144.12, -174.08 64.76, 67.05 -86.64, 13.15 303.01, 98.51 -61.55, -26.65 in-in in 8.7156 Saltbr-in 2.7394 HRD-in -75.89, -41.62 66.66, -9.65 in-in-in SNCiii in-in ActLoopNT-in 2.8599 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.55, 124.4 APE9-dihe-in -129.35, 153.9 APE8-dihe-in -79.47, 68.03 APE8-rot-na 37.65 APE67-dihe-in -68.69, -13.4 -46.24, -36.17 APE12-dist-na 11.499 APE11-dist-na 9.903 APE10-dist-na 10.7107 APE9-dist-in 6.4175 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 30 30 0 [[718, 976]] 1.0 AF-Q15303-K3 Homo sapiens TYR_ERBB4_HUMAN TYR 6.2e-92 313.5 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BCEA Q15303 703 991 1308.0 No_ligand No_ligand Inactive DFGin 6.0916 14.4355 BLAminus -135.99, -161.87 58.5, 65.48 -92.84, 14.19 300.5, 106.96 -58.68, -27.31 in-in in 9.315 Saltbr-in 3.0193 HRD-in -68.09, -45.14 71.02, -10.91 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -126.43, 37.46 APE9-dihe-in -60.63, 140.48 APE8-dihe-in -70.41, 138.16 APE8-rot-na 25.54 APE67-dihe-in -73.08, -10.08 -65.38, -24.14 APE12-dist-na 999.0 APE11-dist-na 6.7444 APE10-dist-na 9.2015 APE9-dist-in 4.9388 None None None XRAY 2.5 0.198 0.251 A 328.0 285.0 4 30 28 2 [[718, 976]] 1.0 3bce Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BCEB Q15303 703 993 1308.0 No_ligand No_ligand Inactive DFGin 6.1958 14.43 BLAminus -142.17, -168.34 59.33, 68.86 -94.24, 18.37 306.31, 104.41 -53.43, -33.51 in-out in 9.3342 Saltbr-out 4.3001 HRD-in -56.3, -51.6 73.77, -8.26 out-in-in SNCoii in-in ActLoopNT-in 2.7951 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 63.14 APE9-dihe-in -67.59, 140.47 APE8-dihe-in -58.71, 139.03 APE8-rot-na 20.16 APE67-dihe-in -73.54, -5.61 -69.18, -26.8 APE12-dist-na 999.0 APE11-dist-na 6.5244 APE10-dist-na 9.3842 APE9-dist-in 4.8922 None None None XRAY 2.5 0.198 0.251 B 328.0 286.0 5 30 28 2 [[718, 976]] 1.0 3bce Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BCEC Q15303 703 990 1308.0 No_ligand No_ligand Inactive DFGin 6.2842 14.3357 BLAminus -139.34, -169.98 72.61, 58.98 -85.97, 21.67 314.92, 93.62 -53.56, -43.33 in-out in 9.3689 Saltbr-out 4.2744 HRD-in -67.32, -52.25 76.29, -9.03 out-in-in SNCoii in-in ActLoopNT-in 2.8843 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.44, 67.91 APE9-dihe-in -67.32, 138.65 APE8-dihe-in -64.36, 136.49 APE8-rot-na 19.89 APE67-dihe-in -70.04, -7.66 -66.17, -25.36 APE12-dist-na 999.0 APE11-dist-na 6.5181 APE10-dist-na 9.3896 APE9-dist-in 4.7144 None None None XRAY 2.5 0.198 0.251 C 328.0 286.0 2 30 28 2 [[718, 976]] 1.0 3bce Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BBWA Q15303 708 991 1308.0 No_ligand No_ligand Inactive DFGin 6.0738 13.0734 BLBplus -127.54, 175.95 65.72, 20.39 -67.87, 137.16 37.62, 79.68 60.16, 23.67 out-out out 14.1039 Saltbr-out 15.0287 HRD-in -62.44, -52.25 83.05, -11.24 out-out-none SNCoon out-none ActLoopNT-out 7.0404 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 50.31 APE8-rot-na 26.37 APE67-dihe-in -69.72, -5.68 -66.64, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.305 0.354 A 328.0 268.0 16 30 16 14 [[718, 976]] 1.0 3bbw Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BBWB Q15303 708 998 1308.0 No_ligand No_ligand Inactive DFGin 6.1544 13.0578 BLBplus -125.64, 179.61 65.63, 18.58 -69.05, 136.5 35.98, 80.62 64.15, 18.09 out-out out 14.1625 Saltbr-out 15.058 HRD-in -62.94, -50.36 84.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 7.1027 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.42 APE8-rot-na 29.99 APE67-dihe-in -69.34, -5.46 -67.52, -43.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 4.0 0.305 0.354 B 328.0 275.0 16 30 16 14 [[718, 976]] 1.0 3bbw Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 2R4BA Q15303 694 991 1308.0 GW7:1 Type1.5_Back Inactive DFGin 4.8884 13.7643 BLBplus -131.45, 171.83 72.48, 18.96 -72.29, 139.7 46.29, 78.43 96.99, -38.5 out-out out 12.4712 Saltbr-out 12.4472 HRD-in -72.41, -53.35 83.43, -17.46 out-out-out SNCooo out-out ActLoopNT-out 6.626 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.99, -22.63 APE9-dihe-in -79.79, 147.87 APE8-dihe-in -66.33, 125.88 APE8-rot-na 22.44 APE67-dihe-in -72.84, -10.87 -47.99, -38.08 APE12-dist-na 16.1637 APE11-dist-na 12.7639 APE10-dist-na 9.1884 APE9-dist-in 5.4581 None None None XRAY 2.4 0.209 0.263 A 321.0 292.0 6 30 30 0 [[718, 976]] 1.0 2r4b Homo sapiens TYR_ERBB4_HUMAN TYR 1.1e-91 312.8 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 2R4BB Q15303 694 991 1308.0 GW7:1 Type1.5_Back Inactive DFGin 4.9841 13.6997 BLBplus -129.8, 173.21 73.77, 11.79 -69.91, 143.8 45.64, 81.74 93.59, -37.44 out-out out 12.5298 Saltbr-out 12.2339 HRD-in -79.37, -52.03 82.87, -19.74 out-out-out SNCooo out-out ActLoopNT-out 6.5003 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.32, -24.68 APE9-dihe-in -77.32, 145.71 APE8-dihe-in -64.77, 128.36 APE8-rot-na 23.01 APE67-dihe-in -77.58, -10.73 -52.3, -32.59 APE12-dist-na 16.1561 APE11-dist-na 12.8936 APE10-dist-na 9.2532 APE9-dist-in 5.4477 None None None XRAY 2.4 0.209 0.263 B 321.0 291.0 7 30 30 0 [[718, 976]] 1.0 2r4b Homo sapiens TYR_ERBB4_HUMAN TYR 1.1e-91 312.8 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BBTB Q15303 708 998 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.3878 13.2905 BLBplus -127.16, 173.3 66.25, 23.71 -69.76, 136.77 43.82, 86.88 52.5, 43.04 out-out out 14.0397 Saltbr-out 15.3219 HRD-in -81.46, -41.77 86.97, -19.99 out-out-none SNCoon out-none ActLoopNT-out 6.9601 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.83 APE8-rot-na 22.98 APE67-dihe-in -74.99, -6.22 -53.46, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 B 328.0 274.0 16 30 16 14 [[718, 976]] 1.0 3bbt Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4
ERBB4 ERBB4_HUMAN 3BBTD Q15303 709 988 1308.0 FMM:60091 Type1.5_Back Inactive DFGin 5.7877 13.6387 BLBplus -120.15, 168.79 64.17, 29.05 -72.9, 132.71 41.75, 86.79 49.44, 51.55 out-out out 14.4078 Saltbr-out 15.8396 HRD-in -78.17, -59.42 94.63, -3.9 out-out-none SNCoon out-none ActLoopNT-out 7.615 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 43.72 APE8-rot-na 29.87 APE67-dihe-in -73.55, -7.87 -60.37, -33.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.253 0.289 D 328.0 259.0 21 30 14 16 [[718, 976]] 1.0 3bbt Homo sapiens TYR_ERBB4_HUMAN TYR 1.2e-91 312.7 2.0 259.0 258.0 860 861 862 864 866 751 768 772 840 842 841 843.0 902 890 885 884 883 882 881 880 879 797 Receptor tyrosine-protein kinase erbB-4

TYR_ERBB4 (Receptor tyrosine-protein kinase erbB-4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name