TYR_EPHB3 (Ephrin type-B receptor 3)

Total number of chains: 6
Active chains: 2
Uniprot: EPHB3_HUMAN
Kinase Domain Residues: 633 - 894
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 66.7% 5L6PA
DFGin BLAminus 2 33.3% AF-P54753-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHB3 AF-P54753-K1A P54753 625 902 998.0 No_ligand No_ligand Active DFGin 5.7493 14.1527 BLAminus -140.36, 179.42 61.35, 72.48 -85.75, 11.94 298.24, 98.38 -58.34, -35.37 in-in in 7.9026 Saltbr-in 2.642 HRD-in -78.07, -44.57 68.31, -14.24 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.19, 128.25 APE9-dihe-in -133.93, 131.98 APE8-dihe-in -78.19, 81.64 APE8-rot-na 36.59 APE67-dihe-in -68.62, -12.96 -41.31, -53.28 APE12-dist-na 13.4759 APE11-dist-na 9.6581 APE10-dist-na 8.3858 APE9-dist-in 5.9374 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 33 33 0 [[633, 894]] 1.0 AF-P54753-K1 TYR_EPHB3_HUMAN TYR 1.9e-105 357.8 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 AF-P54753-K3A P54753 625 902 998.0 No_ligand No_ligand Active DFGin 5.7954 13.8156 BLAminus -144.45, -175.24 63.81, 65.98 -85.57, 9.01 304.03, 103.13 -59.04, -32.59 in-in in 7.9266 Saltbr-in 2.6712 HRD-in -82.82, -48.98 67.74, -9.37 in-in-in SNCiii in-in ActLoopNT-in 2.9356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.11, 140.47 APE9-dihe-in -137.08, 148.64 APE8-dihe-in -76.58, 77.54 APE8-rot-na 36.57 APE67-dihe-in -65.03, -24.4 -39.42, -48.94 APE12-dist-na 14.2568 APE11-dist-na 10.4432 APE10-dist-na 10.1077 APE9-dist-in 5.936 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 33 33 0 [[633, 894]] 1.0 AF-P54753-K3 TYR_EPHB3_HUMAN TYR 1.9e-105 357.8 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 3ZFYA P54753 632 905 998.0 No_ligand No_ligand Inactive DFGin 5.9131 13.19 None -135.83, 169.47 -155.99, -162.71 44.27, 31.84 325.27, 124.04 -167.07, 999.0 in-out in 8.962 Saltbr-out 5.099 HRD-in -71.74, -46.97 81.22, -17.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -13.43 APE9-dihe-in -122.1, 118.82 APE8-dihe-in -85.89, 93.62 APE8-rot-na 31.88 APE67-dihe-in -62.28, -23.15 -49.62, -53.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3289 None None None XRAY 2.2 0.226 0.252 A 298.0 260.0 14 33 25 8 [[633, 894]] 1.0 3zfy TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 3ZFYB P54753 631 905 998.0 No_ligand No_ligand Inactive DFGin 5.9266 13.1757 None -135.57, 169.17 -156.18, -162.85 44.96, 29.53 325.58, 124.75 -172.35, 999.0 in-none in 8.9457 Saltbr-none 999.0 HRD-in -70.36, -48.08 82.24, -17.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.99 APE9-dihe-in -120.26, 118.85 APE8-dihe-in -85.02, 93.24 APE8-rot-na 32.99 APE67-dihe-in -63.33, -22.58 -50.36, -52.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3566 None None None XRAY 2.2 0.226 0.252 B 298.0 255.0 20 33 25 8 [[633, 894]] 1.0 3zfy TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 5L6OA P54753 632 905 998.0 6P6:1001 Type1 Inactive DFGin 6.3789 12.358 None -136.06, 179.55 -169.33, 167.09 62.02, 34.74 338.03, 114.42 -115.47, -169.51 in-in in 8.878 Saltbr-in 3.5045 HRD-in -65.56, -50.53 79.19, -13.37 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.45, 139.28 APE9-dihe-in -128.33, 129.52 APE8-dihe-in -85.6, 95.79 APE8-rot-na 29.74 APE67-dihe-in -63.86, -27.48 -56.29, -41.16 APE12-dist-na 21.3818 APE11-dist-na 17.7016 APE10-dist-na 13.8374 APE9-dist-in 6.5576 A899P None None XRAY 1.88 0.19 0.206 A 298.0 267.0 7 33 29 4 [[633, 894]] 1.0 5l6o TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 5L6PA P54753 632 905 998.0 6P8:1001 Type1 Inactive DFGin 6.9132 13.5082 None -121.71, 172.7 -177.55, 159.52 60.86, 39.03 330.37, 109.09 -99.35, -138.53 in-out in 8.77 Saltbr-out 3.6125 HRD-in -66.38, -48.41 77.7, -5.2 out-out-in SNCooi out-in ActLoopNT-out 19.8833 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.16, 144.59 APE9-dihe-in -127.94, 122.91 APE8-dihe-in -84.6, 92.12 APE8-rot-na 31.43 APE67-dihe-in -59.89, -19.8 -39.97, -57.64 APE12-dist-na 20.9448 APE11-dist-na 17.4017 APE10-dist-na 14.0235 APE9-dist-in 6.299 A899P None None XRAY 2.26 0.206 0.232 A 298.0 274.0 0 33 33 0 [[633, 894]] 1.0 5l6p TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3

TYR_EPHB3 (Ephrin type-B receptor 3)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 66.7% 5L6PA
DFGin BLAminus 2 33.3% AF-P54753-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHB3 EPHB3_HUMAN AF-P54753-K1A P54753 625 902 998.0 No_ligand No_ligand Active DFGin 5.7493 14.1527 BLAminus -140.36, 179.42 61.35, 72.48 -85.75, 11.94 298.24, 98.38 -58.34, -35.37 in-in in 7.9026 Saltbr-in 2.642 HRD-in -78.07, -44.57 68.31, -14.24 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -59.19, 128.25 APE9-dihe-in -133.93, 131.98 APE8-dihe-in -78.19, 81.64 APE8-rot-na 36.59 APE67-dihe-in -68.62, -12.96 -41.31, -53.28 APE12-dist-na 13.4759 APE11-dist-na 9.6581 APE10-dist-na 8.3858 APE9-dist-in 5.9374 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 33 33 0 [[633, 894]] 1.0 AF-P54753-K1 Homo sapiens TYR_EPHB3_HUMAN TYR 1.9e-105 357.8 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 EPHB3_HUMAN AF-P54753-K3A P54753 625 902 998.0 No_ligand No_ligand Active DFGin 5.7954 13.8156 BLAminus -144.45, -175.24 63.81, 65.98 -85.57, 9.01 304.03, 103.13 -59.04, -32.59 in-in in 7.9266 Saltbr-in 2.6712 HRD-in -82.82, -48.98 67.74, -9.37 in-in-in SNCiii in-in ActLoopNT-in 2.9356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.11, 140.47 APE9-dihe-in -137.08, 148.64 APE8-dihe-in -76.58, 77.54 APE8-rot-na 36.57 APE67-dihe-in -65.03, -24.4 -39.42, -48.94 APE12-dist-na 14.2568 APE11-dist-na 10.4432 APE10-dist-na 10.1077 APE9-dist-in 5.936 None None None AF2 -1.0 1.0 1.0 A 278.0 278.0 0 33 33 0 [[633, 894]] 1.0 AF-P54753-K3 Homo sapiens TYR_EPHB3_HUMAN TYR 1.9e-105 357.8 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 EPHB3_HUMAN 3ZFYA P54753 632 905 998.0 No_ligand No_ligand Inactive DFGin 5.9131 13.19 None -135.83, 169.47 -155.99, -162.71 44.27, 31.84 325.27, 124.04 -167.07, 999.0 in-out in 8.962 Saltbr-out 5.099 HRD-in -71.74, -46.97 81.22, -17.57 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -13.43 APE9-dihe-in -122.1, 118.82 APE8-dihe-in -85.89, 93.62 APE8-rot-na 31.88 APE67-dihe-in -62.28, -23.15 -49.62, -53.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3289 None None None XRAY 2.2 0.226 0.252 A 298.0 260.0 14 33 25 8 [[633, 894]] 1.0 3zfy Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 EPHB3_HUMAN 3ZFYB P54753 631 905 998.0 No_ligand No_ligand Inactive DFGin 5.9266 13.1757 None -135.57, 169.17 -156.18, -162.85 44.96, 29.53 325.58, 124.75 -172.35, 999.0 in-none in 8.9457 Saltbr-none 999.0 HRD-in -70.36, -48.08 82.24, -17.0 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -16.99 APE9-dihe-in -120.26, 118.85 APE8-dihe-in -85.02, 93.24 APE8-rot-na 32.99 APE67-dihe-in -63.33, -22.58 -50.36, -52.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3566 None None None XRAY 2.2 0.226 0.252 B 298.0 255.0 20 33 25 8 [[633, 894]] 1.0 3zfy Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 EPHB3_HUMAN 5L6OA P54753 632 905 998.0 6P6:1001 Type1 Inactive DFGin 6.3789 12.358 None -136.06, 179.55 -169.33, 167.09 62.02, 34.74 338.03, 114.42 -115.47, -169.51 in-in in 8.878 Saltbr-in 3.5045 HRD-in -65.56, -50.53 79.19, -13.37 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.45, 139.28 APE9-dihe-in -128.33, 129.52 APE8-dihe-in -85.6, 95.79 APE8-rot-na 29.74 APE67-dihe-in -63.86, -27.48 -56.29, -41.16 APE12-dist-na 21.3818 APE11-dist-na 17.7016 APE10-dist-na 13.8374 APE9-dist-in 6.5576 A899P None None XRAY 1.88 0.19 0.206 A 298.0 267.0 7 33 29 4 [[633, 894]] 1.0 5l6o Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3
EPHB3 EPHB3_HUMAN 5L6PA P54753 632 905 998.0 6P8:1001 Type1 Inactive DFGin 6.9132 13.5082 None -121.71, 172.7 -177.55, 159.52 60.86, 39.03 330.37, 109.09 -99.35, -138.53 in-out in 8.77 Saltbr-out 3.6125 HRD-in -66.38, -48.41 77.7, -5.2 out-out-in SNCooi out-in ActLoopNT-out 19.8833 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.16, 144.59 APE9-dihe-in -127.94, 122.91 APE8-dihe-in -84.6, 92.12 APE8-rot-na 31.43 APE67-dihe-in -59.89, -19.8 -39.97, -57.64 APE12-dist-na 20.9448 APE11-dist-na 17.4017 APE10-dist-na 14.0235 APE9-dist-in 6.299 A899P None None XRAY 2.26 0.206 0.232 A 298.0 274.0 0 33 33 0 [[633, 894]] 1.0 5l6p Homo sapiens TYR_EPHB3_HUMAN TYR 2.4e-105 357.5 2.0 261.0 260.0 775 776 777 779 781 665 682 686 755 757 756 758.0 820 808 803 802 801 800 799 798 797 712 Ephrin type-B receptor 3

TYR_EPHB3 (Ephrin type-B receptor 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name