TYR_EPHA4 (Ephrin type-A receptor 4)

Total number of chains: 2
Active chains: 2
Uniprot: EPHA4_HUMAN
Kinase Domain Residues: 621 - 880
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P54764-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA4 AF-P54764-K1A P54764 613 888 986.0 No_ligand No_ligand Active DFGin 5.9022 14.2641 BLAminus -136.02, -177.75 55.96, 67.44 -82.43, 11.79 296.92, 90.7 -59.41, -32.01 in-in in 8.048 Saltbr-in 2.7194 HRD-in -77.94, -43.64 67.32, -13.72 in-in-in SNCiii in-in ActLoopNT-in 2.8894 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.85, 134.35 APE9-dihe-in -118.41, 129.06 APE8-dihe-in -76.32, 80.51 APE8-rot-na 34.24 APE67-dihe-in -67.4, -12.21 -41.27, -53.91 APE12-dist-na 11.6458 APE11-dist-na 9.4063 APE10-dist-na 9.8372 APE9-dist-in 6.167 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[621, 880]] 1.0 AF-P54764-K1 TYR_EPHA4_HUMAN TYR 1.3e-109 371.4 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 AF-P54764-K3A P54764 613 888 986.0 No_ligand No_ligand Active DFGin 5.8311 14.2043 BLAminus -145.55, -176.42 64.18, 64.33 -82.38, 8.56 298.75, 99.88 -58.94, -32.73 in-in in 8.1832 Saltbr-in 2.68 HRD-in -79.52, -48.14 68.07, -8.04 in-in-in SNCiii in-in ActLoopNT-in 2.9324 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.44, 147.11 APE9-dihe-in -133.28, 142.81 APE8-dihe-in -79.8, 78.49 APE8-rot-na 35.46 APE67-dihe-in -64.4, -25.03 -40.89, -46.86 APE12-dist-na 12.1238 APE11-dist-na 9.7126 APE10-dist-na 10.1851 APE9-dist-in 5.953 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[621, 880]] 1.0 AF-P54764-K3 TYR_EPHA4_HUMAN TYR 1.3e-109 371.4 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4

TYR_EPHA4 (Ephrin type-A receptor 4)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 50.0% AF-P54764-K1A
DFGin None 3 50.0% 2Y6OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA4 EPHA4_HUMAN AF-P54764-K1A P54764 613 888 986.0 No_ligand No_ligand Active DFGin 5.9022 14.2641 BLAminus -136.02, -177.75 55.96, 67.44 -82.43, 11.79 296.92, 90.7 -59.41, -32.01 in-in in 8.048 Saltbr-in 2.7194 HRD-in -77.94, -43.64 67.32, -13.72 in-in-in SNCiii in-in ActLoopNT-in 2.8894 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.85, 134.35 APE9-dihe-in -118.41, 129.06 APE8-dihe-in -76.32, 80.51 APE8-rot-na 34.24 APE67-dihe-in -67.4, -12.21 -41.27, -53.91 APE12-dist-na 11.6458 APE11-dist-na 9.4063 APE10-dist-na 9.8372 APE9-dist-in 6.167 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[621, 880]] 1.0 AF-P54764-K1 Homo sapiens TYR_EPHA4_HUMAN TYR 1.3e-109 371.4 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_HUMAN AF-P54764-K3A P54764 613 888 986.0 No_ligand No_ligand Active DFGin 5.8311 14.2043 BLAminus -145.55, -176.42 64.18, 64.33 -82.38, 8.56 298.75, 99.88 -58.94, -32.73 in-in in 8.1832 Saltbr-in 2.68 HRD-in -79.52, -48.14 68.07, -8.04 in-in-in SNCiii in-in ActLoopNT-in 2.9324 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.44, 147.11 APE9-dihe-in -133.28, 142.81 APE8-dihe-in -79.8, 78.49 APE8-rot-na 35.46 APE67-dihe-in -64.4, -25.03 -40.89, -46.86 APE12-dist-na 12.1238 APE11-dist-na 9.7126 APE10-dist-na 10.1851 APE9-dist-in 5.953 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 31 31 0 [[621, 880]] 1.0 AF-P54764-K3 Homo sapiens TYR_EPHA4_HUMAN TYR 1.3e-109 371.4 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2Y6MA Q03137 609 891 986.0 No_ligand No_ligand Inactive DFGin 6.0821 15.1035 None -124.48, -160.87 67.79, 62.91 -108.47, 999.0 294.78, 105.52 999.0, 999.0 in-in in 8.2842 Saltbr-in 3.23 HRD-in -72.28, -48.83 78.34, -12.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.74 APE8-rot-na 31.74 APE67-dihe-in -75.57, -4.4 -48.65, -50.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.176 0.203 A 291.0 262.0 21 31 10 21 [[621, 880]] 1.0 2y6m Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2XYUA Q03137 612 891 986.0 Q9G:1898 Type1.5_Back Inactive DFGin 6.3198 15.1855 None -125.63, -157.19 61.91, 64.04 -108.95, 999.0 298.3, 101.76 999.0, 999.0 in-out in 8.6238 Saltbr-out 3.6792 HRD-in -75.11, -49.97 80.15, -19.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -122.04 APE8-dihe-in -73.35, 87.97 APE8-rot-na 33.09 APE67-dihe-in -58.55, -20.01 -45.52, -53.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5889 None None None XRAY 2.117 0.192 0.23 A 285.0 260.0 20 31 11 20 [[621, 880]] 1.0 2xyu Mus musculus TYR_EPHA4_MOUSE TYR 1.5e-109 371.3 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2HELA Q03137 613 888 986.0 No_ligand No_ligand None DFGin 5.6319 15.2767 BLAminus -122.71, -163.93 50.59, 80.11 -100.69, 24.95 290.62, 104.83 -61.55, -35.21 in-in in 8.7535 Saltbr-in 2.8418 HRD-in -65.41, -48.34 69.11, 2.02 in-in-none SNCiin in-none ActLoopNT-in 3.1358 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 109.14 APE9-dihe-in -101.32, 124.1 APE8-dihe-in -48.65, 124.73 APE8-rot-na 325.85 APE67-dihe-in -68.37, -4.99 -63.84, -41.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4913 APE9-dist-in 5.5509 Y596F,Y602F,Y742A None None XRAY 2.35 0.209 0.248 A 306.0 256.0 20 31 17 14 [[621, 880]] 1.0 2hel Mus musculus TYR_EPHA4_MOUSE TYR 8.3e-109 368.8 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4

TYR_EPHA4 (Ephrin type-A receptor 4)

Total number of chains: 4
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 75.0% 2Y6OA
DFGin BLAminus 1 25.0% 2HELA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EPHA4 EPHA4_MOUSE 2Y6MA Q03137 609 891 986.0 No_ligand No_ligand Inactive DFGin 6.0821 15.1035 None -124.48, -160.87 67.79, 62.91 -108.47, 999.0 294.78, 105.52 999.0, 999.0 in-in in 8.2842 Saltbr-in 3.23 HRD-in -72.28, -48.83 78.34, -12.81 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.74 APE8-rot-na 31.74 APE67-dihe-in -75.57, -4.4 -48.65, -50.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.176 0.203 A 291.0 262.0 21 31 10 21 [[621, 880]] 1.0 2y6m Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2Y6OA Q03137 609 891 986.0 1N1:1892 Type1 Inactive DFGin 6.5237 15.3156 None -125.69, -163.2 68.45, 65.65 -111.22, 999.0 295.37, 106.51 999.0, 999.0 in-in in 8.2042 Saltbr-in 2.6896 HRD-in -74.99, -48.94 76.82, -16.04 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.47 APE8-dihe-in -69.65, 86.1 APE8-rot-na 27.26 APE67-dihe-in -78.79, 0.73 -48.0, -50.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6377 None None None XRAY 1.543 0.181 0.201 A 291.0 263.0 20 31 11 20 [[621, 880]] 1.0 2y6o Mus musculus TYR_EPHA4_MOUSE TYR 1.6e-109 371.2 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2XYUA Q03137 612 891 986.0 Q9G:1898 Type1.5_Back Inactive DFGin 6.3198 15.1855 None -125.63, -157.19 61.91, 64.04 -108.95, 999.0 298.3, 101.76 999.0, 999.0 in-out in 8.6238 Saltbr-out 3.6792 HRD-in -75.11, -49.97 80.15, -19.41 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -122.04 APE8-dihe-in -73.35, 87.97 APE8-rot-na 33.09 APE67-dihe-in -58.55, -20.01 -45.52, -53.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.5889 None None None XRAY 2.117 0.192 0.23 A 285.0 260.0 20 31 11 20 [[621, 880]] 1.0 2xyu Mus musculus TYR_EPHA4_MOUSE TYR 1.5e-109 371.3 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4
EPHA4 EPHA4_MOUSE 2HELA Q03137 613 888 986.0 No_ligand No_ligand None DFGin 5.6319 15.2767 BLAminus -122.71, -163.93 50.59, 80.11 -100.69, 24.95 290.62, 104.83 -61.55, -35.21 in-in in 8.7535 Saltbr-in 2.8418 HRD-in -65.41, -48.34 69.11, 2.02 in-in-none SNCiin in-none ActLoopNT-in 3.1358 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 109.14 APE9-dihe-in -101.32, 124.1 APE8-dihe-in -48.65, 124.73 APE8-rot-na 325.85 APE67-dihe-in -68.37, -4.99 -63.84, -41.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.4913 APE9-dist-in 5.5509 Y596F,Y602F,Y742A None None XRAY 2.35 0.209 0.248 A 306.0 256.0 20 31 17 14 [[621, 880]] 1.0 2hel Mus musculus TYR_EPHA4_MOUSE TYR 8.3e-109 368.8 1.0 261.0 261.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 4