CMGC_CDK1 (Cyclin-dependent kinase 1)

Total number of chains: 21
Active chains: 2
Family: CMGC
Uniprot: CDK1_HUMAN
Kinase Domain Residues: 4 - 287
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 57.1% AF-P06493-K1A
DFGin BLBplus 9 42.9% 6GU7C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P06493-K1A 1 295 297.0 No_ligand No_ligand Active DFGin 6.847 14.996 BLAminus -139.46, 178.29 52.45, 65.36 -78.13, 16.97 282.4, 71.41 -61.2, -32.43 in-in in 8.809 Saltbr-in 2.805 HRD-in -77.44, -45.62 60.61, 16.97 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 160.63 APE9-dihe-na 62.12, 128.41 APE8-dihe-in -55.43, 135.09 APE8-rot-in 300.46 APE67-dihe-in -65.75, -22.53 -44.64, -45.33 APE12-dist-in 13.029 APE11-dist-in 10.298 APE10-dist-in 6.728 APE9-dist-in 3.25 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[4, 287]] 1.0 AF-P06493-K1 CMGC_CDK1_HUMAN CMGC 2.5e-87 299.0 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
AF-P06493-K3A 1 295 297.0 No_ligand No_ligand Active DFGin 6.661 14.775 BLAminus -136.25, 174.16 56.21, 68.41 -78.41, 13.79 282.1, 76.96 -57.67, -37.4 in-in in 8.906 Saltbr-in 2.754 HRD-in -78.74, -51.17 63.01, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.62, 156.97 APE9-dihe-na 60.42, 132.47 APE8-dihe-in -59.3, 134.64 APE8-rot-in 299.65 APE67-dihe-in -64.68, -25.41 -41.99, -46.73 APE12-dist-in 12.754 APE11-dist-in 9.875 APE10-dist-in 6.565 APE9-dist-in 3.434 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[4, 287]] 1.0 AF-P06493-K3 CMGC_CDK1_HUMAN CMGC 2.5e-87 299.0 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
9SKQA 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.143 16.032 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.716 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.685 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.703 APE11-dist-in 10.027 APE10-dist-in 7.071 APE9-dist-in 3.731 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302 286 0 0 0 0 [[4, 287]] 1.0 9skq CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4YC3A 1 297 297.0 No_ligand No_ligand Inactive DFGin 7.69 15.637 BLAminus -148.63, 167.58 61.15, 77.27 -94.07, 22.11 285.57, 82.14 -64.16, -17.35 in-in in 9.803 Saltbr-in 3.378 HRD-in -78.5, -50.86 78.74, -20.37 in-in-out SNCiio in-out ActLoopNT-in 2.726 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.38 APE8-dihe-in -114.27, 126.99 APE8-rot-out 179.03 APE67-dihe-in -62.94, -21.07 -105.79, -6.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.383 None None None XRAY 2.7 0.214 0.26 A 302 294 3 0 0 3 [[4, 287]] 1.0 4yc3 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
7NJ0B 1 290 297.0 No_ligand No_ligand Inactive DFGin 6.81 15.455 BLAminus -161.96, 170.58 57.81, 73.23 -85.22, 50.1 279.6, 67.13 -65.99, -31.3 in-out in 8.959 Saltbr-out 3.753 HRD-in -63.34, -51.92 65.07, 19.14 out-in-in SNCoii in-in ActLoopNT-in 3.236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.91, -56.78 APE9-dihe-na -90.08, 159.22 APE8-dihe-in -62.51, 134.55 APE8-rot-in 309.63 APE67-dihe-in -71.03, -30.22 -53.29, -29.4 APE12-dist-in 12.577 APE11-dist-in 10.98 APE10-dist-in 6.906 APE9-dist-in 3.971 None TPO161 TPO161 EM 3.6 999.0 999.0 B 318 290 0 0 0 0 [[4, 287]] 1.0 7nj0 CMGC_CDK1_HUMAN CMGC 3.3e-87 298.7 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4Y72A 1 289 297.0 LZ9:60301 Type1 Inactive DFGin 7.685 14.74 BLAminus -147.76, 167.42 62.0, 80.16 -98.31, 21.06 283.74, 78.65 -65.09, -13.07 in-in in 9.239 Saltbr-in 2.93 HRD-in -76.46, -54.64 83.39, -21.52 in-in-out SNCiio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -81.01, 171.83 APE9-dihe-na -73.07, -57.25 APE8-dihe-in -133.62, 133.83 APE8-rot-out 189.36 APE67-dihe-in -61.37, -19.11 -108.24, -11.42 APE12-dist-out 14.177 APE11-dist-in 13.289 APE10-dist-out 9.396 APE9-dist-out 11.289 None None None XRAY 2.3 0.19 0.252 A 302 289 0 0 0 0 [[4, 287]] 1.0 4y72 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
5HQ0A 1 289 297.0 LZ9:60301 Type1 Inactive DFGin 7.685 14.74 BLAminus -147.76, 167.42 62.0, 80.16 -98.31, 21.06 283.74, 78.65 -65.09, -13.07 in-in in 9.239 Saltbr-in 2.93 HRD-in -76.46, -54.64 83.39, -21.52 in-in-out SNCiio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -81.01, 171.83 APE9-dihe-na -73.07, -57.25 APE8-dihe-in -133.62, 133.83 APE8-rot-out 189.36 APE67-dihe-in -61.37, -19.11 -108.24, -11.42 APE12-dist-out 14.177 APE11-dist-in 13.289 APE10-dist-out 9.396 APE9-dist-out 11.289 None None None XRAY 2.3 0.189 0.252 A 302 289 0 0 0 0 [[4, 287]] 1.0 5hq0 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
5LQFA 1 289 297.0 4SP:60301 Type1 Inactive DFGin 7.674 14.683 BLAminus -138.15, 169.23 61.1, 76.26 -94.59, 25.98 280.42, 81.48 -71.64, -17.71 in-in in 9.182 Saltbr-in 2.563 HRD-in -66.11, -52.21 72.94, -4.08 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.13 APE8-dihe-in -99.53, 148.79 APE8-rot-out 178.64 APE67-dihe-in -64.53, -20.89 -112.79, -9.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.204 None None None XRAY 2.06 0.2 0.254 A 302 284 5 0 0 5 [[4, 287]] 1.0 5lqf CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
5LQFD 1 289 297.0 4SP:60301 Type1 Inactive DFGin 7.694 14.65 BLAminus -133.18, 173.28 57.88, 74.37 -88.85, 25.15 291.04, 79.94 -73.26, -15.44 in-in in 9.246 Saltbr-in 2.675 HRD-in -65.87, -50.17 70.5, -11.69 in-in-out SNCiio in-out ActLoopNT-in 2.781 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.65 APE8-rot-out 220.2 APE67-dihe-in -64.07, -22.46 -124.27, -22.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.06 0.2 0.254 D 302 282 7 0 0 7 [[4, 287]] 1.0 5lqf CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU2A 1 294 297.0 F9Z:60301 Type1 Inactive DFGin 7.367 15.527 BLAminus -139.43, 164.03 59.19, 85.76 -98.71, 29.39 285.0, 78.86 -76.67, -15.25 out-out out 10.165 Saltbr-out 4.458 HRD-in -69.24, -49.48 71.95, -8.34 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.39 APE8-dihe-in -78.99, 121.35 APE8-rot-out 68.36 APE67-dihe-in -68.57, -21.46 -99.59, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.58 None None None XRAY 2.0 0.192 0.239 A 302 291 3 0 0 3 [[4, 287]] 1.0 6gu2 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU3A 1 289 297.0 FB8:60301 Type1 Inactive DFGin 7.805 14.564 BLAminus -137.1, 171.09 59.16, 81.74 -96.09, 28.76 285.57, 87.37 -72.84, -16.51 in-in in 9.288 Saltbr-in 2.984 HRD-in -71.79, -50.16 75.69, -26.28 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -37.38, 127.7 APE9-dihe-na -55.03, -59.68 APE8-dihe-in -126.82, 132.63 APE8-rot-out 194.13 APE67-dihe-in -59.08, -25.94 -104.13, -9.36 APE12-dist-in 13.847 APE11-dist-in 11.504 APE10-dist-out 8.776 APE9-dist-out 10.465 None None None XRAY 2.65 0.198 0.258 A 302 289 0 0 0 0 [[4, 287]] 1.0 6gu3 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU4A 1 289 297.0 FC8:60301 Type1 Inactive DFGin 7.581 14.584 BLAminus -145.61, 170.8 53.63, 78.2 -92.59, 26.44 286.38, 84.12 -71.67, -17.29 in-in in 8.963 Saltbr-in 2.833 HRD-in -78.07, -55.7 69.57, -1.83 in-in-out SNCiio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -51.9, 100.35 APE9-dihe-na -20.85, -56.41 APE8-dihe-in -125.37, 142.85 APE8-rot-out 188.74 APE67-dihe-in -66.53, -22.83 -106.3, -18.52 APE12-dist-in 13.768 APE11-dist-in 10.879 APE10-dist-in 7.876 APE9-dist-out 10.153 None None None XRAY 2.73 0.199 0.253 A 302 289 0 0 0 0 [[4, 287]] 1.0 6gu4 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4YC6A 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.206 13.371 BLBplus -114.82, 155.07 69.43, 17.47 -57.04, 138.14 50.4, 83.51 59.01, 8.5 out-out out 14.496 Saltbr-out 15.971 HRD-in -88.24, -68.44 89.41, -55.74 out-out-out SNCooo out-out ActLoopNT-out 6.145 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -45.41, 11.84 APE9-dihe-na -46.42, -50.89 APE8-dihe-out -54.87, -29.75 APE8-rot-out 76.62 APE67-dihe-in -77.02, -16.46 -53.37, -29.92 APE12-dist-out 15.56 APE11-dist-out 15.843 APE10-dist-out 20.444 APE9-dist-out 11.38 None None None XRAY 2.6 0.227 0.267 A 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4YC6C 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.17 13.424 BLBplus -115.87, 155.52 64.41, 18.0 -56.56, 138.21 50.48, 82.7 57.27, 8.32 out-out out 14.477 Saltbr-out 16.0 HRD-in -87.82, -66.01 86.32, -54.95 out-out-out SNCooo out-out ActLoopNT-out 6.211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -45.43, 6.27 APE9-dihe-na -47.39, -47.05 APE8-dihe-out -55.48, -28.31 APE8-rot-out 75.35 APE67-dihe-in -77.34, -17.72 -55.8, -27.51 APE12-dist-out 15.517 APE11-dist-out 15.775 APE10-dist-out 20.372 APE9-dist-out 11.377 None None None XRAY 2.6 0.227 0.267 C 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4YC6E 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.141 13.253 BLBplus -117.12, 155.07 65.38, 17.48 -54.84, 140.62 49.78, 83.78 56.7, 7.44 out-out out 14.451 Saltbr-out 15.915 HRD-in -87.7, -67.17 87.86, -53.89 out-out-out SNCooo out-out ActLoopNT-out 6.218 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -46.75, 14.03 APE9-dihe-na -39.85, -54.82 APE8-dihe-out -53.69, -30.98 APE8-rot-out 76.59 APE67-dihe-in -77.17, -18.26 -53.59, -28.12 APE12-dist-out 15.576 APE11-dist-out 15.92 APE10-dist-out 20.517 APE9-dist-out 11.396 None None None XRAY 2.6 0.227 0.267 E 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
4YC6G 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.194 13.389 BLBplus -115.52, 155.55 64.56, 18.95 -56.33, 139.46 50.35, 83.64 55.47, 7.63 out-out out 14.449 Saltbr-out 15.919 HRD-in -88.11, -67.61 87.18, -54.93 out-out-out SNCooo out-out ActLoopNT-out 6.226 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -48.45, 7.25 APE9-dihe-na -46.58, -48.14 APE8-dihe-out -53.92, -29.79 APE8-rot-out 75.7 APE67-dihe-in -74.81, -18.7 -57.88, -25.9 APE12-dist-out 15.672 APE11-dist-out 15.859 APE10-dist-out 20.435 APE9-dist-out 11.377 None None None XRAY 2.6 0.227 0.267 G 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU7C 1 291 297.0 No_ligand No_ligand Inactive DFGin 5.949 13.398 BLBplus -107.31, 156.68 67.8, 8.48 -46.38, 137.91 57.04, 84.17 72.61, -14.26 out-out out 15.192 Saltbr-out 14.962 HRD-in -80.92, -60.84 81.86, -30.6 out-out-out SNCooo out-out ActLoopNT-out 6.002 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -105.87, -11.29 APE9-dihe-na -57.12, -54.84 APE8-dihe-out -27.85, -44.26 APE8-rot-out 166.81 APE67-dihe-in -63.55, -27.32 -68.5, -32.88 APE12-dist-out 18.256 APE11-dist-out 17.544 APE10-dist-out 21.493 APE9-dist-out 11.932 None None None XRAY 2.75 0.229 0.274 C 302 291 0 0 0 0 [[4, 287]] 1.0 6gu7 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU7E 1 292 297.0 No_ligand No_ligand Inactive DFGin 6.026 13.469 BLBplus -107.29, 155.9 68.0, 8.68 -46.17, 137.77 56.37, 84.56 69.21, -9.55 out-out out 15.076 Saltbr-out 15.018 HRD-in -80.76, -60.06 81.71, -29.2 out-out-out SNCooo out-out ActLoopNT-out 5.803 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.91 APE8-dihe-out -49.07, -44.03 APE8-rot-out 166.66 APE67-dihe-in -64.34, -27.02 -69.42, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.935 None None None XRAY 2.75 0.229 0.274 E 302 284 8 0 0 8 [[4, 287]] 1.0 6gu7 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU7G 1 291 297.0 No_ligand No_ligand Inactive DFGin 5.973 13.391 BLBplus -108.04, 157.62 67.49, 9.03 -46.18, 137.3 55.51, 83.83 62.03, -5.61 out-out out 15.133 Saltbr-out 14.454 HRD-in -80.19, -62.0 67.33, 20.79 out-out-out SNCooo out-out ActLoopNT-out 6.092 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.67 APE8-dihe-out -47.78, -44.46 APE8-rot-out 167.03 APE67-dihe-in -62.13, -27.75 -68.64, -33.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.411 None None None XRAY 2.75 0.229 0.274 G 302 283 8 0 0 8 [[4, 287]] 1.0 6gu7 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU6A 1 291 297.0 1QK:301 Type1 Inactive DFGin 5.818 12.857 BLBplus -115.67, 150.99 76.51, 17.55 -62.08, 137.01 54.81, 86.96 80.64, -12.23 out-out out 15.169 Saltbr-out 15.42 HRD-in -95.81, -60.19 82.87, -21.8 out-out-out SNCooo out-out ActLoopNT-out 5.842 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -35.71, -52.39 APE9-dihe-na -41.22, -41.95 APE8-dihe-out -70.0, -31.83 APE8-rot-out 220.63 APE67-dihe-in -68.3, -21.61 -63.79, -23.1 APE12-dist-out 21.061 APE11-dist-out 15.903 APE10-dist-out 21.588 APE9-dist-out 11.966 None None None XRAY 2.33 0.203 0.246 A 302 288 3 0 0 3 [[4, 287]] 1.0 6gu6 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
6GU7A 1 293 297.0 FB8:301 Type1 Inactive DFGin 5.875 13.148 BLBplus -108.21, 158.14 67.09, 8.94 -46.0, 137.07 56.26, 84.07 59.09, 0.25 out-out out 14.953 Saltbr-out 14.232 HRD-in -80.12, -60.39 82.56, -20.14 out-out-out SNCooo out-out ActLoopNT-out 6.159 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.1 APE8-dihe-out -48.11, -44.27 APE8-rot-out 166.99 APE67-dihe-in -63.08, -28.41 -69.08, -32.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.09 None None None XRAY 2.75 0.229 0.274 A 302 284 9 0 0 9 [[4, 287]] 1.0 6gu7 CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1

CMGC_CDK1 (Cyclin-dependent kinase 1)

Total number of chains: 21
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 57.1% AF-P06493-K1A
DFGin BLBplus 9 42.9% 6GU7C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK1_HUMAN AF-P06493-K1A P06493 1 295 297.0 No_ligand No_ligand Active DFGin 6.847 14.996 BLAminus -139.46, 178.29 52.45, 65.36 -78.13, 16.97 282.4, 71.41 -61.2, -32.43 in-in in 8.809 Saltbr-in 2.805 HRD-in -77.44, -45.62 60.61, 16.97 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 160.63 APE9-dihe-na 62.12, 128.41 APE8-dihe-in -55.43, 135.09 APE8-rot-in 300.46 APE67-dihe-in -65.75, -22.53 -44.64, -45.33 APE12-dist-in 13.029 APE11-dist-in 10.298 APE10-dist-in 6.728 APE9-dist-in 3.25 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[4, 287]] 1.0 AF-P06493-K1 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 299.0 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN AF-P06493-K3A P06493 1 295 297.0 No_ligand No_ligand Active DFGin 6.661 14.775 BLAminus -136.25, 174.16 56.21, 68.41 -78.41, 13.79 282.1, 76.96 -57.67, -37.4 in-in in 8.906 Saltbr-in 2.754 HRD-in -78.74, -51.17 63.01, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.62, 156.97 APE9-dihe-na 60.42, 132.47 APE8-dihe-in -59.3, 134.64 APE8-rot-in 299.65 APE67-dihe-in -64.68, -25.41 -41.99, -46.73 APE12-dist-in 12.754 APE11-dist-in 9.875 APE10-dist-in 6.565 APE9-dist-in 3.434 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[4, 287]] 1.0 AF-P06493-K3 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 299.0 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 9SKQA P06493 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.143 16.032 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.716 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.685 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.703 APE11-dist-in 10.027 APE10-dist-in 7.071 APE9-dist-in 3.731 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302 286 0 0 0 0 [[4, 287]] 1.0 9skq Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4YC3A P06493 1 297 297.0 No_ligand No_ligand Inactive DFGin 7.69 15.637 BLAminus -148.63, 167.58 61.15, 77.27 -94.07, 22.11 285.57, 82.14 -64.16, -17.35 in-in in 9.803 Saltbr-in 3.378 HRD-in -78.5, -50.86 78.74, -20.37 in-in-out SNCiio in-out ActLoopNT-in 2.726 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.38 APE8-dihe-in -114.27, 126.99 APE8-rot-out 179.03 APE67-dihe-in -62.94, -21.07 -105.79, -6.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.383 None None None XRAY 2.7 0.214 0.26 A 302 294 3 0 0 3 [[4, 287]] 1.0 4yc3 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 7NJ0B P06493 1 290 297.0 No_ligand No_ligand Inactive DFGin 6.81 15.455 BLAminus -161.96, 170.58 57.81, 73.23 -85.22, 50.1 279.6, 67.13 -65.99, -31.3 in-out in 8.959 Saltbr-out 3.753 HRD-in -63.34, -51.92 65.07, 19.14 out-in-in SNCoii in-in ActLoopNT-in 3.236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.91, -56.78 APE9-dihe-na -90.08, 159.22 APE8-dihe-in -62.51, 134.55 APE8-rot-in 309.63 APE67-dihe-in -71.03, -30.22 -53.29, -29.4 APE12-dist-in 12.577 APE11-dist-in 10.98 APE10-dist-in 6.906 APE9-dist-in 3.971 None TPO161 TPO161 EM 3.6 999.0 999.0 B 318 290 0 0 0 0 [[4, 287]] 1.0 7nj0 Homo sapiens CMGC_CDK1_HUMAN CMGC 3.3e-87 298.7 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4Y72A P06493 1 289 297.0 LZ9:60301 Type1 Inactive DFGin 7.685 14.74 BLAminus -147.76, 167.42 62.0, 80.16 -98.31, 21.06 283.74, 78.65 -65.09, -13.07 in-in in 9.239 Saltbr-in 2.93 HRD-in -76.46, -54.64 83.39, -21.52 in-in-out SNCiio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -81.01, 171.83 APE9-dihe-na -73.07, -57.25 APE8-dihe-in -133.62, 133.83 APE8-rot-out 189.36 APE67-dihe-in -61.37, -19.11 -108.24, -11.42 APE12-dist-out 14.177 APE11-dist-in 13.289 APE10-dist-out 9.396 APE9-dist-out 11.289 None None None XRAY 2.3 0.19 0.252 A 302 289 0 0 0 0 [[4, 287]] 1.0 4y72 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 5HQ0A P06493 1 289 297.0 LZ9:60301 Type1 Inactive DFGin 7.685 14.74 BLAminus -147.76, 167.42 62.0, 80.16 -98.31, 21.06 283.74, 78.65 -65.09, -13.07 in-in in 9.239 Saltbr-in 2.93 HRD-in -76.46, -54.64 83.39, -21.52 in-in-out SNCiio in-out ActLoopNT-in 2.721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -81.01, 171.83 APE9-dihe-na -73.07, -57.25 APE8-dihe-in -133.62, 133.83 APE8-rot-out 189.36 APE67-dihe-in -61.37, -19.11 -108.24, -11.42 APE12-dist-out 14.177 APE11-dist-in 13.289 APE10-dist-out 9.396 APE9-dist-out 11.289 None None None XRAY 2.3 0.189 0.252 A 302 289 0 0 0 0 [[4, 287]] 1.0 5hq0 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 5LQFA P06493 1 289 297.0 4SP:60301 Type1 Inactive DFGin 7.674 14.683 BLAminus -138.15, 169.23 61.1, 76.26 -94.59, 25.98 280.42, 81.48 -71.64, -17.71 in-in in 9.182 Saltbr-in 2.563 HRD-in -66.11, -52.21 72.94, -4.08 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.13 APE8-dihe-in -99.53, 148.79 APE8-rot-out 178.64 APE67-dihe-in -64.53, -20.89 -112.79, -9.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.204 None None None XRAY 2.06 0.2 0.254 A 302 284 5 0 0 5 [[4, 287]] 1.0 5lqf Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 5LQFD P06493 1 289 297.0 4SP:60301 Type1 Inactive DFGin 7.694 14.65 BLAminus -133.18, 173.28 57.88, 74.37 -88.85, 25.15 291.04, 79.94 -73.26, -15.44 in-in in 9.246 Saltbr-in 2.675 HRD-in -65.87, -50.17 70.5, -11.69 in-in-out SNCiio in-out ActLoopNT-in 2.781 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.65 APE8-rot-out 220.2 APE67-dihe-in -64.07, -22.46 -124.27, -22.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.06 0.2 0.254 D 302 282 7 0 0 7 [[4, 287]] 1.0 5lqf Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU2A P06493 1 294 297.0 F9Z:60301 Type1 Inactive DFGin 7.367 15.527 BLAminus -139.43, 164.03 59.19, 85.76 -98.71, 29.39 285.0, 78.86 -76.67, -15.25 out-out out 10.165 Saltbr-out 4.458 HRD-in -69.24, -49.48 71.95, -8.34 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 52.39 APE8-dihe-in -78.99, 121.35 APE8-rot-out 68.36 APE67-dihe-in -68.57, -21.46 -99.59, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.58 None None None XRAY 2.0 0.192 0.239 A 302 291 3 0 0 3 [[4, 287]] 1.0 6gu2 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU3A P06493 1 289 297.0 FB8:60301 Type1 Inactive DFGin 7.805 14.564 BLAminus -137.1, 171.09 59.16, 81.74 -96.09, 28.76 285.57, 87.37 -72.84, -16.51 in-in in 9.288 Saltbr-in 2.984 HRD-in -71.79, -50.16 75.69, -26.28 in-in-out SNCiio in-out ActLoopNT-in 2.745 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -37.38, 127.7 APE9-dihe-na -55.03, -59.68 APE8-dihe-in -126.82, 132.63 APE8-rot-out 194.13 APE67-dihe-in -59.08, -25.94 -104.13, -9.36 APE12-dist-in 13.847 APE11-dist-in 11.504 APE10-dist-out 8.776 APE9-dist-out 10.465 None None None XRAY 2.65 0.198 0.258 A 302 289 0 0 0 0 [[4, 287]] 1.0 6gu3 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU4A P06493 1 289 297.0 FC8:60301 Type1 Inactive DFGin 7.581 14.584 BLAminus -145.61, 170.8 53.63, 78.2 -92.59, 26.44 286.38, 84.12 -71.67, -17.29 in-in in 8.963 Saltbr-in 2.833 HRD-in -78.07, -55.7 69.57, -1.83 in-in-out SNCiio in-out ActLoopNT-in 2.807 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -51.9, 100.35 APE9-dihe-na -20.85, -56.41 APE8-dihe-in -125.37, 142.85 APE8-rot-out 188.74 APE67-dihe-in -66.53, -22.83 -106.3, -18.52 APE12-dist-in 13.768 APE11-dist-in 10.879 APE10-dist-in 7.876 APE9-dist-out 10.153 None None None XRAY 2.73 0.199 0.253 A 302 289 0 0 0 0 [[4, 287]] 1.0 6gu4 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4YC6A P06493 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.206 13.371 BLBplus -114.82, 155.07 69.43, 17.47 -57.04, 138.14 50.4, 83.51 59.01, 8.5 out-out out 14.496 Saltbr-out 15.971 HRD-in -88.24, -68.44 89.41, -55.74 out-out-out SNCooo out-out ActLoopNT-out 6.145 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -45.41, 11.84 APE9-dihe-na -46.42, -50.89 APE8-dihe-out -54.87, -29.75 APE8-rot-out 76.62 APE67-dihe-in -77.02, -16.46 -53.37, -29.92 APE12-dist-out 15.56 APE11-dist-out 15.843 APE10-dist-out 20.444 APE9-dist-out 11.38 None None None XRAY 2.6 0.227 0.267 A 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4YC6C P06493 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.17 13.424 BLBplus -115.87, 155.52 64.41, 18.0 -56.56, 138.21 50.48, 82.7 57.27, 8.32 out-out out 14.477 Saltbr-out 16.0 HRD-in -87.82, -66.01 86.32, -54.95 out-out-out SNCooo out-out ActLoopNT-out 6.211 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -45.43, 6.27 APE9-dihe-na -47.39, -47.05 APE8-dihe-out -55.48, -28.31 APE8-rot-out 75.35 APE67-dihe-in -77.34, -17.72 -55.8, -27.51 APE12-dist-out 15.517 APE11-dist-out 15.775 APE10-dist-out 20.372 APE9-dist-out 11.377 None None None XRAY 2.6 0.227 0.267 C 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4YC6E P06493 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.141 13.253 BLBplus -117.12, 155.07 65.38, 17.48 -54.84, 140.62 49.78, 83.78 56.7, 7.44 out-out out 14.451 Saltbr-out 15.915 HRD-in -87.7, -67.17 87.86, -53.89 out-out-out SNCooo out-out ActLoopNT-out 6.218 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -46.75, 14.03 APE9-dihe-na -39.85, -54.82 APE8-dihe-out -53.69, -30.98 APE8-rot-out 76.59 APE67-dihe-in -77.17, -18.26 -53.59, -28.12 APE12-dist-out 15.576 APE11-dist-out 15.92 APE10-dist-out 20.517 APE9-dist-out 11.396 None None None XRAY 2.6 0.227 0.267 E 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 4YC6G P06493 1 289 297.0 No_ligand No_ligand Inactive DFGin 6.194 13.389 BLBplus -115.52, 155.55 64.56, 18.95 -56.33, 139.46 50.35, 83.64 55.47, 7.63 out-out out 14.449 Saltbr-out 15.919 HRD-in -88.11, -67.61 87.18, -54.93 out-out-out SNCooo out-out ActLoopNT-out 6.226 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -48.45, 7.25 APE9-dihe-na -46.58, -48.14 APE8-dihe-out -53.92, -29.79 APE8-rot-out 75.7 APE67-dihe-in -74.81, -18.7 -57.88, -25.9 APE12-dist-out 15.672 APE11-dist-out 15.859 APE10-dist-out 20.435 APE9-dist-out 11.377 None None None XRAY 2.6 0.227 0.267 G 297 285 4 0 0 4 [[4, 287]] 1.0 4yc6 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.5e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU7C P06493 1 291 297.0 No_ligand No_ligand Inactive DFGin 5.949 13.398 BLBplus -107.31, 156.68 67.8, 8.48 -46.38, 137.91 57.04, 84.17 72.61, -14.26 out-out out 15.192 Saltbr-out 14.962 HRD-in -80.92, -60.84 81.86, -30.6 out-out-out SNCooo out-out ActLoopNT-out 6.002 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -105.87, -11.29 APE9-dihe-na -57.12, -54.84 APE8-dihe-out -27.85, -44.26 APE8-rot-out 166.81 APE67-dihe-in -63.55, -27.32 -68.5, -32.88 APE12-dist-out 18.256 APE11-dist-out 17.544 APE10-dist-out 21.493 APE9-dist-out 11.932 None None None XRAY 2.75 0.229 0.274 C 302 291 0 0 0 0 [[4, 287]] 1.0 6gu7 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU7E P06493 1 292 297.0 No_ligand No_ligand Inactive DFGin 6.026 13.469 BLBplus -107.29, 155.9 68.0, 8.68 -46.17, 137.77 56.37, 84.56 69.21, -9.55 out-out out 15.076 Saltbr-out 15.018 HRD-in -80.76, -60.06 81.71, -29.2 out-out-out SNCooo out-out ActLoopNT-out 5.803 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.91 APE8-dihe-out -49.07, -44.03 APE8-rot-out 166.66 APE67-dihe-in -64.34, -27.02 -69.42, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.935 None None None XRAY 2.75 0.229 0.274 E 302 284 8 0 0 8 [[4, 287]] 1.0 6gu7 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU7G P06493 1 291 297.0 No_ligand No_ligand Inactive DFGin 5.973 13.391 BLBplus -108.04, 157.62 67.49, 9.03 -46.18, 137.3 55.51, 83.83 62.03, -5.61 out-out out 15.133 Saltbr-out 14.454 HRD-in -80.19, -62.0 67.33, 20.79 out-out-out SNCooo out-out ActLoopNT-out 6.092 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.67 APE8-dihe-out -47.78, -44.46 APE8-rot-out 167.03 APE67-dihe-in -62.13, -27.75 -68.64, -33.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.411 None None None XRAY 2.75 0.229 0.274 G 302 283 8 0 0 8 [[4, 287]] 1.0 6gu7 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU6A P06493 1 291 297.0 1QK:301 Type1 Inactive DFGin 5.818 12.857 BLBplus -115.67, 150.99 76.51, 17.55 -62.08, 137.01 54.81, 86.96 80.64, -12.23 out-out out 15.169 Saltbr-out 15.42 HRD-in -95.81, -60.19 82.87, -21.8 out-out-out SNCooo out-out ActLoopNT-out 5.842 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -35.71, -52.39 APE9-dihe-na -41.22, -41.95 APE8-dihe-out -70.0, -31.83 APE8-rot-out 220.63 APE67-dihe-in -68.3, -21.61 -63.79, -23.1 APE12-dist-out 21.061 APE11-dist-out 15.903 APE10-dist-out 21.588 APE9-dist-out 11.966 None None None XRAY 2.33 0.203 0.246 A 302 288 3 0 0 3 [[4, 287]] 1.0 6gu6 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CDK1_HUMAN 6GU7A P06493 1 293 297.0 FB8:301 Type1 Inactive DFGin 5.875 13.148 BLBplus -108.21, 158.14 67.09, 8.94 -46.0, 137.07 56.26, 84.07 59.09, 0.25 out-out out 14.953 Saltbr-out 14.232 HRD-in -80.12, -60.39 82.56, -20.14 out-out-out SNCooo out-out ActLoopNT-out 6.159 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -32.1 APE8-dihe-out -48.11, -44.27 APE8-rot-out 166.99 APE67-dihe-in -63.08, -28.41 -69.08, -32.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.09 None None None XRAY 2.75 0.229 0.274 A 302 284 9 0 0 9 [[4, 287]] 1.0 6gu7 Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1

CMGC_CDK1 (Cyclin-dependent kinase 1)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name