CAMK_CAMKII (Calcium/calmodulin-dependent protein kinase type II)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name

CAMK_CAMKII (Calcium/calmodulin-dependent protein kinase type II)

Total number of chains: 14
Active chains: 4
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 14 100.0% 3KK8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KCC2D_CAEEL 2BDWA O62305 5 309 720.0 No_ligand No_ligand Active DFGin 7.272 15.988 BLAminus -116.53, 174.92 55.86, 88.92 -100.15, 26.2 286.82, 86.82 -61.14, -26.93 in-in in 9.099 Saltbr-in 2.718 HRD-in -69.47, -49.67 71.62, -3.03 in-in-in SNCiii in-in ActLoopNT-in 3.033 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.99, 155.82 APE9-dihe-na 117.74, 165.95 APE8-dihe-in -77.47, 143.42 APE8-rot-in 298.48 APE67-dihe-in -81.18, -8.52 -49.81, -40.43 APE12-dist-in 10.623 APE11-dist-in 11.581 APE10-dist-in 5.99 APE9-dist-in 3.473 N44N None None XRAY 1.8 0.216 0.236 A 362 305 0 0 0 0 [[12, 269]] 1.0 2bdw Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 5.3e-96 326.9 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8A O62305 10 273 720.0 No_ligand No_ligand Inactive DFGin 5.885 14.906 BLAminus -144.36, 171.99 65.11, 87.91 -103.17, 26.18 296.88, 75.2 -51.71, -38.61 out-out out 10.928 Saltbr-out 5.413 HRD-in -79.65, -51.87 79.19, -55.97 out-in-in SNCoii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.74, 163.84 APE9-dihe-na 135.26, 176.74 APE8-dihe-in -90.67, 128.12 APE8-rot-in 304.11 APE67-dihe-inflip 136.53, -34.54 -64.77, 111.65 APE12-dist-in 9.818 APE11-dist-in 11.192 APE10-dist-in 6.037 APE9-dist-in 4.396 D134N None None XRAY 3.372 0.234 0.281 A 269 256 8 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8C O62305 7 273 720.0 No_ligand No_ligand Inactive DFGin 5.841 14.858 BLAminus -146.01, 171.08 65.36, 86.28 -102.71, 27.71 298.79, 73.75 -52.29, -38.48 out-out out 10.992 Saltbr-out 5.383 HRD-in -80.04, -52.99 79.67, -55.41 out-in-in SNCoii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.46, 164.07 APE9-dihe-na 133.86, 175.97 APE8-dihe-in -91.98, 127.83 APE8-rot-in 303.01 APE67-dihe-inflip 135.91, -33.92 -65.62, 111.79 APE12-dist-in 9.87 APE11-dist-in 11.189 APE10-dist-in 6.05 APE9-dist-in 4.381 D134N None None XRAY 3.372 0.234 0.281 C 269 256 11 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8E O62305 7 273 720.0 No_ligand No_ligand Inactive DFGin 5.884 14.921 BLAminus -145.36, 173.49 62.2, 88.51 -103.38, 25.9 297.69, 74.94 -50.75, -38.44 out-out out 10.963 Saltbr-out 5.383 HRD-in -81.66, -52.27 79.01, -55.6 out-in-in SNCoii in-in ActLoopNT-in 3.061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 164.51 APE9-dihe-na 134.05, 175.69 APE8-dihe-in -89.41, 129.17 APE8-rot-in 304.61 APE67-dihe-inflip 134.64, -34.4 -67.04, 113.48 APE12-dist-in 9.796 APE11-dist-in 11.2 APE10-dist-in 6.029 APE9-dist-in 4.37 D134N None None XRAY 3.372 0.234 0.281 E 269 256 11 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8G O62305 6 273 720.0 No_ligand No_ligand Inactive DFGin 5.87 14.911 BLAminus -145.06, 172.53 62.65, 87.84 -103.94, 25.4 297.34, 74.35 -49.74, -38.91 out-out out 10.995 Saltbr-out 5.431 HRD-in -80.55, -52.44 78.4, -53.55 out-in-in SNCoii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.92, 163.0 APE9-dihe-na 133.94, 173.54 APE8-dihe-in -88.3, 128.91 APE8-rot-in 302.93 APE67-dihe-inflip 138.88, -35.46 -65.56, 110.82 APE12-dist-in 9.854 APE11-dist-in 11.169 APE10-dist-in 6.03 APE9-dist-in 4.325 D134N None None XRAY 3.372 0.234 0.281 G 269 259 9 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8I O62305 6 271 720.0 No_ligand No_ligand Inactive DFGin 5.88 14.871 BLAminus -142.86, 171.42 64.31, 87.38 -102.92, 26.31 298.24, 74.94 -50.88, -40.14 out-out out 10.994 Saltbr-out 5.396 HRD-in -79.36, -52.86 79.07, -55.85 out-in-in SNCoii in-in ActLoopNT-in 3.051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.07, 164.01 APE9-dihe-na 133.9, 174.75 APE8-dihe-in -88.55, 128.87 APE8-rot-in 303.78 APE67-dihe-inflip 136.12, -33.68 -65.68, 111.07 APE12-dist-in 9.85 APE11-dist-in 11.212 APE10-dist-in 6.055 APE9-dist-in 4.339 D134N None None XRAY 3.372 0.234 0.281 I 269 254 12 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KK9A O62305 6 287 720.0 No_ligand No_ligand Inactive DFGin 6.049 15.12 BLAminus -146.33, -171.45 46.02, 74.17 -91.18, 16.01 295.4, 65.99 -51.16, -18.79 in-out in 9.943 Saltbr-out 4.926 HRD-in -84.99, -46.96 79.26, -38.56 out-in-in SNCoii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.12, 150.77 APE9-dihe-na 153.21, -154.97 APE8-dihe-in -127.45, 129.84 APE8-rot-in 293.08 APE67-dihe-in -55.07, -9.93 -30.63, -76.69 APE12-dist-in 10.611 APE11-dist-in 11.835 APE10-dist-in 6.372 APE9-dist-in 4.109 D134N TPO284 TPO284 XRAY 3.206 0.272 0.329 A 282 276 0 0 0 0 [[12, 269]] 1.0 3kk9 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 2.2e-96 328.0 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KK8A O62305 5 288 720.0 No_ligand No_ligand Inactive DFGin 6.271 15.795 BLAminus -132.36, 174.01 59.26, 78.84 -94.69, 24.02 285.52, 79.93 -64.47, -19.01 out-out out 10.174 Saltbr-out 4.525 HRD-in -76.72, -44.77 73.56, -8.73 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.62, 150.23 APE9-dihe-na 145.28, -160.35 APE8-dihe-in -119.47, 128.01 APE8-rot-in 296.41 APE67-dihe-in -69.87, -13.89 -44.38, -49.1 APE12-dist-in 10.416 APE11-dist-in 11.859 APE10-dist-in 6.235 APE9-dist-in 3.627 D134N TPO284 TPO284 XRAY 1.72 0.179 0.216 A 284 284 0 0 0 0 [[12, 269]] 1.0 3kk8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 2.3e-96 328.0 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 2BDWB O62305 8 309 720.0 No_ligand No_ligand Inactive DFGin 6.38 15.249 BLAminus -126.34, 175.86 58.64, 85.42 -98.08, 25.48 284.4, 80.76 -58.96, -25.44 in-out in 9.936 Saltbr-out 4.545 HRD-in -65.17, -48.76 68.49, 0.99 out-in-in SNCoii in-in ActLoopNT-in 3.097 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.94, 142.87 APE9-dihe-na 116.04, -177.33 APE8-dihe-in -93.7, 131.39 APE8-rot-in 304.25 APE67-dihe-in -63.54, -15.86 -45.53, -48.71 APE12-dist-in 10.701 APE11-dist-in 11.897 APE10-dist-in 5.961 APE9-dist-in 3.839 N44N None None XRAY 1.8 0.216 0.236 B 362 302 0 0 0 0 [[12, 269]] 1.0 2bdw Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 5.3e-96 326.9 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.883 14.23 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.996 Saltbr-in 2.798 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.208 APE11-dist-in 11.816 APE10-dist-in 6.289 APE9-dist-in 3.479 None None None XRAY 1.955 0.192 0.221 A 285 269 0 0 0 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
KCC2A_DROME 5H9BA Q00168 7 275 530.0 AN2:301 ATPlike Active DFGin 5.687 14.14 BLAminus -121.83, -177.58 63.45, 84.2 -103.14, 25.35 292.56, 80.33 -62.44, -18.79 in-in in 9.014 Saltbr-in 2.65 HRD-in -79.17, -42.13 69.98, 5.32 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.23, 154.68 APE9-dihe-na 138.91, -156.64 APE8-dihe-in -125.98, 126.82 APE8-rot-in 298.36 APE67-dihe-in -64.57, -17.97 -35.44, -64.1 APE12-dist-in 10.217 APE11-dist-in 11.689 APE10-dist-in 6.016 APE9-dist-in 3.419 None None None XRAY 2.25 0.204 0.222 A 285 269 0 0 0 0 [[14, 272]] 1.0 5h9b Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.625 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.952 Saltbr-in 2.671 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.059 APE11-dist-in 11.766 APE10-dist-in 6.277 APE9-dist-in 3.564 D136N None None XRAY 1.885 0.194 0.228 A 285 266 0 0 0 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
F2UPG5_SALR5 5IG1A F2UPG5 1 300 479.0 No_ligand No_ligand Inactive DFGin 6.557 14.927 BLAminus -157.83, -173.91 53.72, 81.21 -96.24, 25.88 290.98, 84.81 -62.0, -35.62 in-in in 9.209 Saltbr-in 3.104 HRD-in -63.84, -40.55 71.09, -17.47 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.85, 163.85 APE9-dihe-na 113.74, 160.73 APE8-dihe-in -82.09, 141.89 APE8-rot-out 43.99 APE67-dihe-in -59.21, -27.73 -57.76, -42.83 APE12-dist-in 9.982 APE11-dist-in 11.567 APE10-dist-in 5.837 APE9-dist-in 3.821 None None None XRAY 2.9 0.185 0.224 A 344 300 0 0 0 0 [[16, 273]] 1.0 5ig1 Salpingoeca rosetta CAMK_CAMKII_SALR5 CAMK 7.5e-94 320.0 5 256 252 158 159 160 162 164 45 63 67 135 137 136 138 197 185 180 179 178 177 176 175 174 93 calcium/calmodulin-dependent protein kinase
F2UPG5_SALR5 5IG1B F2UPG5 1 304 479.0 No_ligand No_ligand Inactive DFGin 6.554 14.914 BLAminus -150.95, -166.93 52.53, 71.5 -88.64, 26.13 291.1, 83.43 -61.58, -14.18 in-out in 9.253 Saltbr-out 5.697 HRD-in -70.55, -37.26 68.7, -18.33 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.43, 163.37 APE9-dihe-na 125.72, 179.06 APE8-dihe-in -96.26, 136.73 APE8-rot-out 46.59 APE67-dihe-in -56.1, -26.2 -60.32, -42.7 APE12-dist-in 9.912 APE11-dist-in 11.581 APE10-dist-in 5.909 APE9-dist-in 4.056 None None None XRAY 2.9 0.185 0.224 B 344 304 0 0 0 0 [[16, 273]] 1.0 5ig1 Salpingoeca rosetta CAMK_CAMKII_SALR5 CAMK 7.5e-94 320.0 5 256 252 158 159 160 162 164 45 63 67 135 137 136 138 197 185 180 179 178 177 176 175 174 93 calcium/calmodulin-dependent protein kinase

CAMK_CAMKII (Calcium/calmodulin-dependent protein kinase type II)

Total number of chains: 14
Active chains: 4
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 14 100.0% 3KK8A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KCC2D_CAEEL 2BDWA O62305 5 309 720.0 No_ligand No_ligand Active DFGin 7.272 15.988 BLAminus -116.53, 174.92 55.86, 88.92 -100.15, 26.2 286.82, 86.82 -61.14, -26.93 in-in in 9.099 Saltbr-in 2.718 HRD-in -69.47, -49.67 71.62, -3.03 in-in-in SNCiii in-in ActLoopNT-in 3.033 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.99, 155.82 APE9-dihe-na 117.74, 165.95 APE8-dihe-in -77.47, 143.42 APE8-rot-in 298.48 APE67-dihe-in -81.18, -8.52 -49.81, -40.43 APE12-dist-in 10.623 APE11-dist-in 11.581 APE10-dist-in 5.99 APE9-dist-in 3.473 N44N None None XRAY 1.8 0.216 0.236 A 362 305 0 0 0 0 [[12, 269]] 1.0 2bdw Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 5.3e-96 326.9 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8A O62305 10 273 720.0 No_ligand No_ligand Inactive DFGin 5.885 14.906 BLAminus -144.36, 171.99 65.11, 87.91 -103.17, 26.18 296.88, 75.2 -51.71, -38.61 out-out out 10.928 Saltbr-out 5.413 HRD-in -79.65, -51.87 79.19, -55.97 out-in-in SNCoii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.74, 163.84 APE9-dihe-na 135.26, 176.74 APE8-dihe-in -90.67, 128.12 APE8-rot-in 304.11 APE67-dihe-inflip 136.53, -34.54 -64.77, 111.65 APE12-dist-in 9.818 APE11-dist-in 11.192 APE10-dist-in 6.037 APE9-dist-in 4.396 D134N None None XRAY 3.372 0.234 0.281 A 269 256 8 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8C O62305 7 273 720.0 No_ligand No_ligand Inactive DFGin 5.841 14.858 BLAminus -146.01, 171.08 65.36, 86.28 -102.71, 27.71 298.79, 73.75 -52.29, -38.48 out-out out 10.992 Saltbr-out 5.383 HRD-in -80.04, -52.99 79.67, -55.41 out-in-in SNCoii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.46, 164.07 APE9-dihe-na 133.86, 175.97 APE8-dihe-in -91.98, 127.83 APE8-rot-in 303.01 APE67-dihe-inflip 135.91, -33.92 -65.62, 111.79 APE12-dist-in 9.87 APE11-dist-in 11.189 APE10-dist-in 6.05 APE9-dist-in 4.381 D134N None None XRAY 3.372 0.234 0.281 C 269 256 11 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8E O62305 7 273 720.0 No_ligand No_ligand Inactive DFGin 5.884 14.921 BLAminus -145.36, 173.49 62.2, 88.51 -103.38, 25.9 297.69, 74.94 -50.75, -38.44 out-out out 10.963 Saltbr-out 5.383 HRD-in -81.66, -52.27 79.01, -55.6 out-in-in SNCoii in-in ActLoopNT-in 3.061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 164.51 APE9-dihe-na 134.05, 175.69 APE8-dihe-in -89.41, 129.17 APE8-rot-in 304.61 APE67-dihe-inflip 134.64, -34.4 -67.04, 113.48 APE12-dist-in 9.796 APE11-dist-in 11.2 APE10-dist-in 6.029 APE9-dist-in 4.37 D134N None None XRAY 3.372 0.234 0.281 E 269 256 11 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8G O62305 6 273 720.0 No_ligand No_ligand Inactive DFGin 5.87 14.911 BLAminus -145.06, 172.53 62.65, 87.84 -103.94, 25.4 297.34, 74.35 -49.74, -38.91 out-out out 10.995 Saltbr-out 5.431 HRD-in -80.55, -52.44 78.4, -53.55 out-in-in SNCoii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.92, 163.0 APE9-dihe-na 133.94, 173.54 APE8-dihe-in -88.3, 128.91 APE8-rot-in 302.93 APE67-dihe-inflip 138.88, -35.46 -65.56, 110.82 APE12-dist-in 9.854 APE11-dist-in 11.169 APE10-dist-in 6.03 APE9-dist-in 4.325 D134N None None XRAY 3.372 0.234 0.281 G 269 259 9 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KL8I O62305 6 271 720.0 No_ligand No_ligand Inactive DFGin 5.88 14.871 BLAminus -142.86, 171.42 64.31, 87.38 -102.92, 26.31 298.24, 74.94 -50.88, -40.14 out-out out 10.994 Saltbr-out 5.396 HRD-in -79.36, -52.86 79.07, -55.85 out-in-in SNCoii in-in ActLoopNT-in 3.051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.07, 164.01 APE9-dihe-na 133.9, 174.75 APE8-dihe-in -88.55, 128.87 APE8-rot-in 303.78 APE67-dihe-inflip 136.12, -33.68 -65.68, 111.07 APE12-dist-in 9.85 APE11-dist-in 11.212 APE10-dist-in 6.055 APE9-dist-in 4.339 D134N None None XRAY 3.372 0.234 0.281 I 269 254 12 0 0 0 [[12, 269]] 1.0 3kl8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 1.9e-96 328.3 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KK9A O62305 6 287 720.0 No_ligand No_ligand Inactive DFGin 6.049 15.12 BLAminus -146.33, -171.45 46.02, 74.17 -91.18, 16.01 295.4, 65.99 -51.16, -18.79 in-out in 9.943 Saltbr-out 4.926 HRD-in -84.99, -46.96 79.26, -38.56 out-in-in SNCoii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.12, 150.77 APE9-dihe-na 153.21, -154.97 APE8-dihe-in -127.45, 129.84 APE8-rot-in 293.08 APE67-dihe-in -55.07, -9.93 -30.63, -76.69 APE12-dist-in 10.611 APE11-dist-in 11.835 APE10-dist-in 6.372 APE9-dist-in 4.109 D134N TPO284 TPO284 XRAY 3.206 0.272 0.329 A 282 276 0 0 0 0 [[12, 269]] 1.0 3kk9 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 2.2e-96 328.0 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 3KK8A O62305 5 288 720.0 No_ligand No_ligand Inactive DFGin 6.271 15.795 BLAminus -132.36, 174.01 59.26, 78.84 -94.69, 24.02 285.52, 79.93 -64.47, -19.01 out-out out 10.174 Saltbr-out 4.525 HRD-in -76.72, -44.77 73.56, -8.73 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.62, 150.23 APE9-dihe-na 145.28, -160.35 APE8-dihe-in -119.47, 128.01 APE8-rot-in 296.41 APE67-dihe-in -69.87, -13.89 -44.38, -49.1 APE12-dist-in 10.416 APE11-dist-in 11.859 APE10-dist-in 6.235 APE9-dist-in 3.627 D134N TPO284 TPO284 XRAY 1.72 0.179 0.216 A 284 284 0 0 0 0 [[12, 269]] 1.0 3kk8 Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 2.3e-96 328.0 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2D_CAEEL 2BDWB O62305 8 309 720.0 No_ligand No_ligand Inactive DFGin 6.38 15.249 BLAminus -126.34, 175.86 58.64, 85.42 -98.08, 25.48 284.4, 80.76 -58.96, -25.44 in-out in 9.936 Saltbr-out 4.545 HRD-in -65.17, -48.76 68.49, 0.99 out-in-in SNCoii in-in ActLoopNT-in 3.097 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.94, 142.87 APE9-dihe-na 116.04, -177.33 APE8-dihe-in -93.7, 131.39 APE8-rot-in 304.25 APE67-dihe-in -63.54, -15.86 -45.53, -48.71 APE12-dist-in 10.701 APE11-dist-in 11.897 APE10-dist-in 5.961 APE9-dist-in 3.839 N44N None None XRAY 1.8 0.216 0.236 B 362 302 0 0 0 0 [[12, 269]] 1.0 2bdw Caenorhabditis elegans CAMK_CAMKII_CAEEL CAMK 5.3e-96 326.9 1 256 256 154 155 156 158 160 41 59 63 131 133 132 134 193 181 176 175 174 173 172 171 170 89 Calcium/calmodulin-dependent protein kinase type II
KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.883 14.23 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.996 Saltbr-in 2.798 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.208 APE11-dist-in 11.816 APE10-dist-in 6.289 APE9-dist-in 3.479 None None None XRAY 1.955 0.192 0.221 A 285 269 0 0 0 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
KCC2A_DROME 5H9BA Q00168 7 275 530.0 AN2:301 ATPlike Active DFGin 5.687 14.14 BLAminus -121.83, -177.58 63.45, 84.2 -103.14, 25.35 292.56, 80.33 -62.44, -18.79 in-in in 9.014 Saltbr-in 2.65 HRD-in -79.17, -42.13 69.98, 5.32 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.23, 154.68 APE9-dihe-na 138.91, -156.64 APE8-dihe-in -125.98, 126.82 APE8-rot-in 298.36 APE67-dihe-in -64.57, -17.97 -35.44, -64.1 APE12-dist-in 10.217 APE11-dist-in 11.689 APE10-dist-in 6.016 APE9-dist-in 3.419 None None None XRAY 2.25 0.204 0.222 A 285 269 0 0 0 0 [[14, 272]] 1.0 5h9b Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.625 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.952 Saltbr-in 2.671 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.059 APE11-dist-in 11.766 APE10-dist-in 6.277 APE9-dist-in 3.564 D136N None None XRAY 1.885 0.194 0.228 A 285 266 0 0 0 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
F2UPG5_SALR5 5IG1A F2UPG5 1 300 479.0 No_ligand No_ligand Inactive DFGin 6.557 14.927 BLAminus -157.83, -173.91 53.72, 81.21 -96.24, 25.88 290.98, 84.81 -62.0, -35.62 in-in in 9.209 Saltbr-in 3.104 HRD-in -63.84, -40.55 71.09, -17.47 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.85, 163.85 APE9-dihe-na 113.74, 160.73 APE8-dihe-in -82.09, 141.89 APE8-rot-out 43.99 APE67-dihe-in -59.21, -27.73 -57.76, -42.83 APE12-dist-in 9.982 APE11-dist-in 11.567 APE10-dist-in 5.837 APE9-dist-in 3.821 None None None XRAY 2.9 0.185 0.224 A 344 300 0 0 0 0 [[16, 273]] 1.0 5ig1 Salpingoeca rosetta CAMK_CAMKII_SALR5 CAMK 7.5e-94 320.0 5 256 252 158 159 160 162 164 45 63 67 135 137 136 138 197 185 180 179 178 177 176 175 174 93 calcium/calmodulin-dependent protein kinase
F2UPG5_SALR5 5IG1B F2UPG5 1 304 479.0 No_ligand No_ligand Inactive DFGin 6.554 14.914 BLAminus -150.95, -166.93 52.53, 71.5 -88.64, 26.13 291.1, 83.43 -61.58, -14.18 in-out in 9.253 Saltbr-out 5.697 HRD-in -70.55, -37.26 68.7, -18.33 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.43, 163.37 APE9-dihe-na 125.72, 179.06 APE8-dihe-in -96.26, 136.73 APE8-rot-out 46.59 APE67-dihe-in -56.1, -26.2 -60.32, -42.7 APE12-dist-in 9.912 APE11-dist-in 11.581 APE10-dist-in 5.909 APE9-dist-in 4.056 None None None XRAY 2.9 0.185 0.224 B 344 304 0 0 0 0 [[16, 273]] 1.0 5ig1 Salpingoeca rosetta CAMK_CAMKII_SALR5 CAMK 7.5e-94 320.0 5 256 252 158 159 160 162 164 45 63 67 135 137 136 138 197 185 180 179 178 177 176 175 174 93 calcium/calmodulin-dependent protein kinase