TKL_BMPR1A (Bone morphogenetic protein receptor type-1A)

Total number of chains: 2
Active chains: 2
Family: TKL
Uniprot: BMR1A_HUMAN
Kinase Domain Residues: 234 - 523
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P36894-K1A

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P36894-K1A 226 531 532.0 No_ligand No_ligand Active DFGin 6.685 13.3 BLAminus DFGAsp-rot-in -128.07, 175.08 57.59, 68.94 193.09, 35.7 -86.82, 17.83 298.24, 178.44 -63.45, -19.3 in-in in 8.354 Saltbr-in 2.686 HRD-in -75.05, -41.46 65.97, -16.14 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.39, 165.95 APE9-dihe-na 98.92, -176.03 APE8-dihe-in -83.12, 111.74 APE8-rot-in 303.75 APE67-dihe-in -58.73, -28.03 -42.35, -43.88 APE12-dist-in 11.248 APE11-dist-in 12.048 APE10-dist-in 6.191 APE9-dist-in 3.86 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[233, 523]] 1.0 AF-P36894-K1 TKL_BMPR1A_HUMAN TKL 1.3e-81 280.0 3 266 264 379 380 381 383 385 261 274 278 359 361 360 362 429 411 406 405 404 403 402 401 400 310 Bone morphogenetic protein receptor type-1A
AF-P36894-K3A 226 531 532.0 No_ligand No_ligand Active DFGin 6.19 12.158 BLAminus DFGAsp-rot-in -140.9889, 176.6589 55.9623, 62.3588 185.7363, 33.9706 -79.6486, 17.9843 303.6397, 176.7584 -63.337, -16.6531 in-in in 8.859 Saltbr-in 2.596 HRD-in -75.0484, -37.7996 66.9596, -27.973 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.313, 134.6525 APE9-dihe-na 141.4737, -165.0139 APE8-dihe-in -95.9415, 94.1727 APE8-rot-in 312.6617 APE67-dihe-in -57.2432, -25.5791 -36.4089, -46.8996 APE12-dist-in 9.892 APE11-dist-in 11.812 APE10-dist-in 7.026 APE9-dist-in 5.49 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[233, 523]] 1.0 AF-P36894-K3 TKL_BMPR1A_HUMAN TKL 1.3e-81 280.0 3 266 264 379 380 381 383 385 261 274 278 359 361 360 362 429 411 406 405 404 403 402 401 400 310 Bone morphogenetic protein receptor type-1A

TKL_BMPR1A (Bone morphogenetic protein receptor type-1A)

Total number of chains: 2
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% AF-P36894-K1A

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
BMR1A_HUMAN AF-P36894-K1A P36894 226 531 532.0 No_ligand No_ligand Active DFGin 6.685 13.3 BLAminus DFGAsp-rot-in -128.07, 175.08 57.59, 68.94 193.09, 35.7 -86.82, 17.83 298.24, 178.44 -63.45, -19.3 in-in in 8.354 Saltbr-in 2.686 HRD-in -75.05, -41.46 65.97, -16.14 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.39, 165.95 APE9-dihe-na 98.92, -176.03 APE8-dihe-in -83.12, 111.74 APE8-rot-in 303.75 APE67-dihe-in -58.73, -28.03 -42.35, -43.88 APE12-dist-in 11.248 APE11-dist-in 12.048 APE10-dist-in 6.191 APE9-dist-in 3.86 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[233, 523]] 1.0 AF-P36894-K1 Homo sapiens TKL_BMPR1A_HUMAN TKL 1.3e-81 280.0 3 266 264 379 380 381 383 385 261 274 278 359 361 360 362 429 411 406 405 404 403 402 401 400 310 Bone morphogenetic protein receptor type-1A
BMR1A_HUMAN AF-P36894-K3A P36894 226 531 532.0 No_ligand No_ligand Active DFGin 6.19 12.158 BLAminus DFGAsp-rot-in -140.9889, 176.6589 55.9623, 62.3588 185.7363, 33.9706 -79.6486, 17.9843 303.6397, 176.7584 -63.337, -16.6531 in-in in 8.859 Saltbr-in 2.596 HRD-in -75.0484, -37.7996 66.9596, -27.973 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.313, 134.6525 APE9-dihe-na 141.4737, -165.0139 APE8-dihe-in -95.9415, 94.1727 APE8-rot-in 312.6617 APE67-dihe-in -57.2432, -25.5791 -36.4089, -46.8996 APE12-dist-in 9.892 APE11-dist-in 11.812 APE10-dist-in 7.026 APE9-dist-in 5.49 None None None AF2 -1.0 1.0 1.0 A 306 306 0 0 0 0 [[233, 523]] 1.0 AF-P36894-K3 Homo sapiens TKL_BMPR1A_HUMAN TKL 1.3e-81 280.0 3 266 264 379 380 381 383 385 261 274 278 359 361 360 362 429 411 406 405 404 403 402 401 400 310 Bone morphogenetic protein receptor type-1A

TKL_BMPR1A (Bone morphogenetic protein receptor type-1A)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name