TKL_ACVR2B (Activin receptor type-2B)

Total number of chains: 3
Active chains: 3
Family: TKL
Uniprot: AVR2B_HUMAN
Kinase Domain Residues: 190 - 480
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q13705-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q13705-K1A 182 488 512.0 No_ligand No_ligand Active DFGin 7.082 13.945 BLAminus -134.99, 169.46 61.66, 72.65 -85.96, 19.26 301.83, 106.8 -63.43, -19.44 in-in in 7.989 Saltbr-in 2.719 HRD-in -75.14, -44.15 65.31, -4.73 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 162.57 APE9-dihe-na 110.9, -170.62 APE8-dihe-in -86.94, 112.33 APE8-rot-in 303.58 APE67-dihe-in -57.15, -27.67 -45.76, -44.56 APE12-dist-in 10.683 APE11-dist-in 12.249 APE10-dist-in 6.359 APE9-dist-in 3.64 None None None AF2 -1.0 1.0 1.0 A 307 307 0 0 0 0 [[190, 480]] 1.0 AF-Q13705-K1 TKL_ACVR2B_HUMAN TKL 1.2e-76 263.7 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B
AF-Q13705-K3A 182 488 512.0 No_ligand No_ligand Active DFGin 7.123 13.927 BLAminus -140.31, 175.57 60.65, 62.0 -78.91, 20.25 302.17, 117.58 -64.7, -20.24 in-in in 7.874 Saltbr-in 2.662 HRD-in -76.36, -43.27 64.73, 5.52 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.79, 165.72 APE9-dihe-na 97.32, -166.38 APE8-dihe-in -87.99, 112.95 APE8-rot-in 304.04 APE67-dihe-in -58.27, -25.11 -43.09, -45.85 APE12-dist-in 10.55 APE11-dist-in 12.168 APE10-dist-in 6.271 APE9-dist-in 3.734 None None None AF2 -1.0 1.0 1.0 A 307 307 0 0 0 0 [[190, 480]] 1.0 AF-Q13705-K3 TKL_ACVR2B_HUMAN TKL 1.2e-76 263.7 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B
2QLUA 190 484 512.0 ADE:60488 Type1 Active DFGin 7.282 13.919 BLAminus -143.64, 166.04 72.05, 78.25 -102.89, 27.27 300.97, 123.79 -72.21, -17.92 in-in in 7.945 Saltbr-in 3.516 HRD-in -60.9, -56.13 82.96, -12.74 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.21, -18.6 APE9-dihe-na -82.16, 165.01 APE8-dihe-in -51.41, 126.96 APE8-rot-in 299.08 APE67-dihe-in -55.0, -24.76 -57.11, -46.21 APE12-dist-in 11.038 APE11-dist-in 12.1 APE10-dist-in 6.113 APE9-dist-in 3.548 None None None XRAY 2.0 0.219 0.283 A 314 295 0 0 0 0 [[190, 480]] 1.0 2qlu TKL_ACVR2B_HUMAN TKL 1.3e-76 263.6 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B

TKL_ACVR2B (Activin receptor type-2B)

Total number of chains: 3
Active chains: 3
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% AF-Q13705-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AVR2B_HUMAN AF-Q13705-K1A Q13705 182 488 512.0 No_ligand No_ligand Active DFGin 7.082 13.945 BLAminus -134.99, 169.46 61.66, 72.65 -85.96, 19.26 301.83, 106.8 -63.43, -19.44 in-in in 7.989 Saltbr-in 2.719 HRD-in -75.14, -44.15 65.31, -4.73 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.56, 162.57 APE9-dihe-na 110.9, -170.62 APE8-dihe-in -86.94, 112.33 APE8-rot-in 303.58 APE67-dihe-in -57.15, -27.67 -45.76, -44.56 APE12-dist-in 10.683 APE11-dist-in 12.249 APE10-dist-in 6.359 APE9-dist-in 3.64 None None None AF2 -1.0 1.0 1.0 A 307 307 0 0 0 0 [[190, 480]] 1.0 AF-Q13705-K1 Homo sapiens TKL_ACVR2B_HUMAN TKL 1.2e-76 263.7 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B
AVR2B_HUMAN AF-Q13705-K3A Q13705 182 488 512.0 No_ligand No_ligand Active DFGin 7.123 13.927 BLAminus -140.31, 175.57 60.65, 62.0 -78.91, 20.25 302.17, 117.58 -64.7, -20.24 in-in in 7.874 Saltbr-in 2.662 HRD-in -76.36, -43.27 64.73, 5.52 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.79, 165.72 APE9-dihe-na 97.32, -166.38 APE8-dihe-in -87.99, 112.95 APE8-rot-in 304.04 APE67-dihe-in -58.27, -25.11 -43.09, -45.85 APE12-dist-in 10.55 APE11-dist-in 12.168 APE10-dist-in 6.271 APE9-dist-in 3.734 None None None AF2 -1.0 1.0 1.0 A 307 307 0 0 0 0 [[190, 480]] 1.0 AF-Q13705-K3 Homo sapiens TKL_ACVR2B_HUMAN TKL 1.2e-76 263.7 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B
AVR2B_HUMAN 2QLUA Q13705 190 484 512.0 ADE:60488 Type1 Active DFGin 7.282 13.919 BLAminus -143.64, 166.04 72.05, 78.25 -102.89, 27.27 300.97, 123.79 -72.21, -17.92 in-in in 7.945 Saltbr-in 3.516 HRD-in -60.9, -56.13 82.96, -12.74 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.21, -18.6 APE9-dihe-na -82.16, 165.01 APE8-dihe-in -51.41, 126.96 APE8-rot-in 299.08 APE67-dihe-in -55.0, -24.76 -57.11, -46.21 APE12-dist-in 11.038 APE11-dist-in 12.1 APE10-dist-in 6.113 APE9-dist-in 3.548 None None None XRAY 2.0 0.219 0.283 A 314 295 0 0 0 0 [[190, 480]] 1.0 2qlu Homo sapiens TKL_ACVR2B_HUMAN TKL 1.3e-76 263.6 2 265 264 338 339 340 342 344 217 230 234 318 320 319 321 385 368 363 362 361 360 359 358 357 266 Activin receptor type-2B

TKL_ACVR2B (Activin receptor type-2B)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name