OTHER / All / All

Total number of chains: 572
Active chains: 156
Total number of genes: 50
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 351 61.4% AF-Q2M2I8-K1A
DFGin ABAminus 97 17.0% AF-Q504Y2-K3A
DFGin None 37 6.5% 5O23A
DFGin BLBplus 22 3.8% 3P23C
None None 19 3.3% 7BL1CCC
DFGin BLBminus 18 3.1% 5O1VA
DFGout None 13 2.3% 6O5ZB
DFGout BBAminus 5 0.9% 6FDZU
DFGin BLAplus 4 0.7% 7JXUA
DFGin BLBtrans 3 0.5% 5J0AA
DFGinter None 2 0.3% 8OMVE
DFGinter BABtrans 1 0.2% 7QWKH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER AAK1 AAK1_HUMAN AF-Q2M2I8-K1A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 6.09 13.157 BLAminus DFGAsp-rot-in -130.76, 177.11 65.46, 72.88 197.28, 19.59 -86.17, 13.75 306.15, 100.85 -62.63, -26.92 in-in in 8.694 Saltbr-in 2.695 HRD-in -71.29, -40.47 67.96, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, 1.5 APE9-dihe-na -133.56, 144.49 APE8-dihe-in -85.09, 124.69 APE8-rot-in 302.03 APE67-dihe-in -65.48, -12.52 -47.91, -50.11 APE12-dist-in 12.105 APE11-dist-in 8.386 APE10-dist-in 4.177 APE9-dist-in 3.763 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[46, 313]] 1.0 AF-Q2M2I8-K1 OTHER_AAK1_HUMAN OTHER 2.5e-41 147.8 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN AF-Q2M2I8-K3A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 5.909 13.37 BLAminus DFGAsp-rot-in -128.17, 175.79 57.92, 95.09 195.75, 11.93 -102.83, 15.36 298.99, 95.97 -62.48, -26.93 in-in in 8.805 Saltbr-in 2.686 HRD-in -73.71, -40.34 66.99, -5.58 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, -5.0 APE9-dihe-na -133.21, 117.79 APE8-dihe-in -58.72, 127.19 APE8-rot-in 304.31 APE67-dihe-in -63.7, -12.57 -50.37, -47.6 APE12-dist-in 12.025 APE11-dist-in 8.459 APE10-dist-in 4.129 APE9-dist-in 3.489 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[46, 313]] 1.0 AF-Q2M2I8-K3 OTHER_AAK1_HUMAN OTHER 2.5e-41 147.8 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 4WSQA Q2M2I8 29 345 961.0 KSA:405 Type1 Active DFGin 6.307 13.753 BLAminus DFGAsp-rot-in -126.2, -179.67 69.61, 90.76 189.29, 6.58 -108.14, 19.69 293.57, 82.96 -69.52, -19.34 in-in in 9.524 Saltbr-in 3.051 HRD-in -67.42, -46.62 67.64, 3.19 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.1, -8.47 APE9-dihe-na -120.84, 162.67 APE8-dihe-in -101.84, 124.39 APE8-rot-in 300.18 APE67-dihe-in -59.62, -25.15 -50.19, -46.52 APE12-dist-in 12.377 APE11-dist-in 8.831 APE10-dist-in 4.474 APE9-dist-in 3.675 None None None XRAY 1.95 0.182 0.208 A 317 317 0 0 0 0 [[46, 313]] 1.0 4wsq OTHER_AAK1_HUMAN OTHER 3.7e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 4WSQB Q2M2I8 33 342 961.0 KSA:404 Type1 Active DFGin 6.448 13.491 BLAminus DFGAsp-rot-in -125.14, -178.62 72.01, 91.87 192.16, 10.35 -111.17, 20.84 297.62, 84.5 -70.3, -20.72 in-in in 9.31 Saltbr-in 2.743 HRD-in -70.2, -48.3 68.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -7.92 APE9-dihe-na -118.96, 162.19 APE8-dihe-in -104.95, 123.2 APE8-rot-in 302.88 APE67-dihe-in -62.15, -24.37 -51.37, -45.33 APE12-dist-in 12.208 APE11-dist-in 8.557 APE10-dist-in 4.25 APE9-dist-in 3.744 None None None XRAY 1.95 0.182 0.208 B 317 310 0 0 0 0 [[46, 313]] 1.0 4wsq OTHER_AAK1_HUMAN OTHER 3.7e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMCA Q2M2I8 34 330 961.0 YFV:401 Type1 Active DFGin 6.296 13.344 BLAminus DFGAsp-rot-in -132.35, 179.07 63.58, 102.47 196.13, -10.49 -106.53, 19.35 292.32, 96.59 -60.5, -34.69 in-in in 8.502 Saltbr-in 2.74 HRD-in -65.3, -44.13 71.44, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.27, -5.42 APE9-dihe-na -117.59, 149.82 APE8-dihe-in -99.03, 116.29 APE8-rot-in 299.63 APE67-dihe-in -50.9, -25.95 -44.55, -54.08 APE12-dist-in 12.229 APE11-dist-in 8.532 APE10-dist-in 4.19 APE9-dist-in 3.881 None None None XRAY 2.5 0.228 0.256 A 318 293 4 0 0 0 [[46, 313]] 1.0 8gmc OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMCB Q2M2I8 31 330 961.0 YFV:401 Type1 Active DFGin 6.613 13.444 BLAminus DFGAsp-rot-in -132.15, -179.67 62.85, 102.24 197.65, -11.66 -105.78, 18.46 292.58, 96.33 -60.62, -34.17 in-in in 8.465 Saltbr-in 2.937 HRD-in -65.77, -42.15 71.41, -5.73 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.13, -3.18 APE9-dihe-na -121.52, 151.08 APE8-dihe-in -97.1, 121.04 APE8-rot-in 308.13 APE67-dihe-in -59.64, -26.78 -53.61, -40.63 APE12-dist-in 12.181 APE11-dist-in 8.453 APE10-dist-in 4.154 APE9-dist-in 3.979 None None None XRAY 2.5 0.228 0.256 B 318 294 5 0 0 0 [[46, 313]] 1.0 8gmc OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMDA Q2M2I8 34 329 961.0 ZRR:401 Type1 Active DFGin 6.167 13.332 BLAminus DFGAsp-rot-in -127.52, 174.84 65.86, 97.82 199.81, -17.0 -104.03, 21.57 300.09, 93.49 -64.42, -30.01 in-in in 8.576 Saltbr-in 2.784 HRD-in -64.68, -46.09 71.69, -3.04 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.71, -15.11 APE9-dihe-na -111.33, 160.49 APE8-dihe-in -104.37, 121.78 APE8-rot-in 304.75 APE67-dihe-in -58.75, -28.21 -47.17, -46.33 APE12-dist-in 12.163 APE11-dist-in 8.434 APE10-dist-in 4.147 APE9-dist-in 3.566 None None None XRAY 2.2 0.233 0.25 A 318 294 2 0 0 0 [[46, 313]] 1.0 8gmd OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMDB Q2M2I8 29 330 961.0 ZRR:401 Type1 Active DFGin 6.372 13.478 BLAminus DFGAsp-rot-in -123.19, 179.01 67.0, 97.52 199.99, -11.05 -104.44, 17.42 296.06, 83.59 -61.74, -25.96 in-in in 8.432 Saltbr-in 2.778 HRD-in -64.58, -45.6 71.56, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.95, -11.7 APE9-dihe-na -117.06, 155.74 APE8-dihe-in -98.45, 121.78 APE8-rot-in 305.28 APE67-dihe-in -59.45, -28.48 -46.11, -46.72 APE12-dist-in 12.178 APE11-dist-in 8.374 APE10-dist-in 4.143 APE9-dist-in 3.597 None None None XRAY 2.2 0.233 0.25 B 318 299 3 0 0 0 [[46, 313]] 1.0 8gmd OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 9QB5A Q2M2I8 29 343 961.0 F7I:60401 Type1 Active DFGin 6.406 13.358 BLAminus DFGAsp-rot-in -132.26, 177.36 64.71, 93.28 193.9, 0.85 -102.58, 23.65 295.99, 87.8 -68.89, -14.08 in-in in 8.452 Saltbr-in 2.577 HRD-in -65.82, -48.18 75.53, -3.07 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.0, -10.1 APE9-dihe-na -117.28, 159.33 APE8-dihe-in -101.85, 125.23 APE8-rot-in 303.31 APE67-dihe-in -61.58, -23.49 -52.0, -46.22 APE12-dist-in 12.158 APE11-dist-in 8.502 APE10-dist-in 4.126 APE9-dist-in 3.632 None None None XRAY 2.0 0.199 0.227 A 318 313 2 0 0 0 [[46, 313]] 1.0 9qb5 OTHER_AAK1_HUMAN OTHER 3.8e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 9QB5B Q2M2I8 34 342 961.0 F7I:60401 Type1 Active DFGin 6.457 13.039 BLAminus DFGAsp-rot-in -136.45, 178.27 73.68, 94.2 180.67, 27.95 -109.77, 25.54 300.89, 108.71 -73.91, -11.3 in-in in 8.092 Saltbr-in 2.462 HRD-in -66.48, -48.55 75.65, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.0, -6.97 APE9-dihe-na -121.88, 160.23 APE8-dihe-in -103.81, 124.81 APE8-rot-in 304.19 APE67-dihe-in -60.83, -28.74 -52.63, -42.77 APE12-dist-in 12.174 APE11-dist-in 8.578 APE10-dist-in 4.303 APE9-dist-in 3.664 None None None XRAY 2.0 0.199 0.227 B 318 309 0 0 0 0 [[46, 313]] 1.0 9qb5 OTHER_AAK1_HUMAN OTHER 3.8e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5L4QA Q2M2I8 33 335 961.0 LKB:401 Type1 Active DFGin 6.005 13.227 BLAminus DFGAsp-rot-in -132.85, -177.94 63.93, 92.35 189.81, -1.97 -114.27, 19.37 301.1, 98.45 -80.74, -11.63 in-in in 8.685 Saltbr-in 2.708 HRD-in -67.77, -48.62 71.48, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.55, -17.02 APE9-dihe-na -109.84, 154.17 APE8-dihe-in -96.17, 123.72 APE8-rot-in 302.79 APE67-dihe-in -62.67, -23.02 -45.97, -51.51 APE12-dist-in 11.999 APE11-dist-in 8.35 APE10-dist-in 4.067 APE9-dist-in 3.483 None None None XRAY 1.97 0.208 0.227 A 346 293 10 0 0 0 [[46, 313]] 1.0 5l4q OTHER_AAK1_HUMAN OTHER 4.9e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5L4QB Q2M2I8 33 333 961.0 LKB:401 Type1 Active DFGin 6.001 13.253 BLAminus DFGAsp-rot-in -132.29, -178.13 64.06, 92.67 190.87, -1.78 -114.66, 18.46 300.35, 97.82 -80.3, -11.3 in-in in 8.565 Saltbr-in 2.714 HRD-in -67.84, -48.94 70.89, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.29, -16.57 APE9-dihe-na -109.81, 154.98 APE8-dihe-in -96.35, 124.27 APE8-rot-in 304.05 APE67-dihe-in -62.49, -22.16 -46.27, -52.25 APE12-dist-in 11.956 APE11-dist-in 8.401 APE10-dist-in 4.043 APE9-dist-in 3.505 None None None XRAY 1.97 0.208 0.227 B 346 287 14 0 0 0 [[46, 313]] 1.0 5l4q OTHER_AAK1_HUMAN OTHER 4.9e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5TE0A Q2M2I8 27 345 961.0 XIN:60401 Type1 Active DFGin 6.177 13.729 BLAminus DFGAsp-rot-in -133.95, 173.97 66.46, 103.31 204.49, -24.01 -110.15, 22.69 304.86, 94.85 -65.74, -20.86 in-in in 9.055 Saltbr-in 3.491 HRD-in -62.42, -46.29 70.69, -4.02 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -11.26 APE9-dihe-na -114.88, 156.03 APE8-dihe-in -99.05, 119.5 APE8-rot-in 300.83 APE67-dihe-in -58.27, -25.82 -45.89, -49.71 APE12-dist-in 12.141 APE11-dist-in 8.398 APE10-dist-in 4.146 APE9-dist-in 3.731 None None None XRAY 1.9 0.182 0.199 A 347 315 4 0 0 0 [[46, 313]] 1.0 5te0 OTHER_AAK1_HUMAN OTHER 5e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER BMP2K BMP2K_HUMAN 5I3OA Q9NSY1 42 343 1161.0 IDV:401 Type1 Inactive DFGin 6.008 13.446 ABAminus DFGAsp-rot-in -120.1, -5.03 -132.33, 129.9 193.19, -69.57 -127.42, 29.15 302.78, 91.82 -66.76, -26.7 in-in in 9.122 Saltbr-in 2.781 HRD-in -64.64, -49.2 69.4, 6.0 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.33, -6.45 APE9-dihe-na -125.78, 155.7 APE8-dihe-in -95.47, 122.26 APE8-rot-in 307.86 APE67-dihe-in -55.87, -33.13 -47.99, -45.79 APE12-dist-in 12.235 APE11-dist-in 8.665 APE10-dist-in 4.395 APE9-dist-in 3.771 K320A,K321A None None XRAY 2.4 0.196 0.255 A 302 302 0 0 0 0 [[51, 317]] 1.0 5i3o OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3OB Q9NSY1 42 343 1161.0 IDV:401 Type1 Inactive DFGin 6.042 13.461 ABAminus DFGAsp-rot-in -120.67, -6.79 -129.61, 129.54 195.64, -72.12 -126.94, 28.43 302.96, 91.57 -62.02, -28.58 in-in in 9.101 Saltbr-in 2.753 HRD-in -66.18, -48.36 68.58, 5.95 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.19, -8.28 APE9-dihe-na -123.37, 154.68 APE8-dihe-in -93.77, 122.1 APE8-rot-in 309.24 APE67-dihe-in -54.86, -33.89 -49.2, -45.64 APE12-dist-in 12.417 APE11-dist-in 8.893 APE10-dist-in 4.391 APE9-dist-in 3.794 K320A,K321A None None XRAY 2.4 0.196 0.255 B 302 302 0 0 0 0 [[51, 317]] 1.0 5i3o OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3RA Q9NSY1 42 343 1161.0 IDK:401 Type1 Inactive DFGin 6.073 13.442 ABAminus DFGAsp-rot-in -120.88, 4.16 -140.09, 134.02 200.13, -73.22 -133.38, 24.78 303.01, 88.22 -60.75, -27.07 in-in in 9.297 Saltbr-in 2.792 HRD-in -70.25, -47.7 70.76, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.8, -5.41 APE9-dihe-na -124.44, 153.57 APE8-dihe-in -93.38, 120.19 APE8-rot-in 303.38 APE67-dihe-in -56.33, -27.62 -45.73, -49.35 APE12-dist-in 12.238 APE11-dist-in 8.589 APE10-dist-in 4.319 APE9-dist-in 3.817 K320A,K321A None None XRAY 2.4 0.188 0.231 A 302 302 0 0 0 0 [[51, 317]] 1.0 5i3r OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3RB Q9NSY1 42 343 1161.0 IDK:401 Type1 Inactive DFGin 6.078 13.533 ABAminus DFGAsp-rot-in -120.46, 2.49 -138.36, 133.12 202.54, -73.26 -133.05, 26.32 303.01, 89.8 -59.31, -28.21 in-in in 9.247 Saltbr-in 2.75 HRD-in -69.47, -46.69 69.4, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.92, -7.13 APE9-dihe-na -121.37, 153.36 APE8-dihe-in -93.4, 120.36 APE8-rot-in 304.62 APE67-dihe-in -56.13, -27.91 -46.4, -48.23 APE12-dist-in 12.26 APE11-dist-in 8.594 APE10-dist-in 4.332 APE9-dist-in 3.851 K320A,K321A None None XRAY 2.4 0.188 0.231 B 302 302 0 0 0 0 [[51, 317]] 1.0 5i3r OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5IKWA Q9NSY1 42 338 1161.0 6BU:4000 Type1 Inactive DFGin 6.042 13.759 ABAminus DFGAsp-rot-in -119.43, -4.98 -129.37, 129.38 185.78, -26.64 -129.09, 20.57 297.97, 99.91 -68.53, -10.14 in-in in 9.195 Saltbr-in 3.004 HRD-in -64.63, -50.21 70.81, 5.02 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.97, -10.12 APE9-dihe-na -119.45, 162.83 APE8-dihe-in -105.19, 120.82 APE8-rot-in 296.01 APE67-dihe-in -55.22, -22.41 -41.84, -57.19 APE12-dist-in 12.275 APE11-dist-in 8.615 APE10-dist-in 4.295 APE9-dist-in 3.637 K320A,K321A None None XRAY 2.41 0.178 0.216 A 310 297 0 0 0 0 [[51, 317]] 1.0 5ikw OTHER_BMP2K_HUMAN NEK 4e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN AF-Q9NSY1-K1A Q9NSY1 43 325 1161.0 No_ligand No_ligand Active DFGin 6.108 13.255 BLAminus DFGAsp-rot-in -126.14, 177.99 64.0, 77.73 196.7, 19.51 -88.88, 12.98 305.14, 100.06 -61.82, -29.21 in-in in 8.805 Saltbr-in 2.708 HRD-in -70.79, -40.6 67.46, -13.46 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, 5.92 APE9-dihe-na -136.17, 146.78 APE8-dihe-in -87.8, 125.04 APE8-rot-in 301.53 APE67-dihe-in -64.17, -12.69 -49.11, -50.5 APE12-dist-in 12.104 APE11-dist-in 8.439 APE10-dist-in 4.181 APE9-dist-in 3.734 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[51, 317]] 1.0 AF-Q9NSY1-K1 OTHER_BMP2K_HUMAN NEK 2.9e-39 141.2 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN AF-Q9NSY1-K3A Q9NSY1 43 325 1161.0 No_ligand No_ligand Active DFGin 5.933 13.381 BLAminus DFGAsp-rot-in -133.43, -179.24 58.5, 79.43 195.81, 21.06 -91.11, 12.54 300.28, 97.52 -62.53, -30.02 in-in in 8.759 Saltbr-in 2.704 HRD-in -74.93, -43.05 69.43, -12.68 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.92, 5.19 APE9-dihe-na -136.99, 142.69 APE8-dihe-in -81.51, 123.81 APE8-rot-in 305.07 APE67-dihe-in -63.69, -10.39 -48.67, -48.71 APE12-dist-in 12.009 APE11-dist-in 8.49 APE10-dist-in 4.123 APE9-dist-in 3.887 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[51, 317]] 1.0 AF-Q9NSY1-K3 OTHER_BMP2K_HUMAN NEK 2.9e-39 141.2 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 4W9XA Q9NSY1 39 342 1161.0 3JW:403 Type1 Active DFGin 6.334 13.568 BLAminus DFGAsp-rot-in -134.66, 171.76 65.13, 87.84 192.64, -11.24 -97.17, 19.7 303.81, 101.33 -58.31, -30.65 in-in in 8.925 Saltbr-in 2.45 HRD-in -72.21, -49.47 77.86, -6.69 in-in-in SNCiii in-in ActLoopNT-in 2.762 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.12, -14.48 APE9-dihe-na -117.03, 162.86 APE8-dihe-in -112.23, 128.85 APE8-rot-in 299.05 APE67-dihe-in -58.38, -19.69 -56.81, -49.31 APE12-dist-in 12.23 APE11-dist-in 8.445 APE10-dist-in 4.336 APE9-dist-in 3.754 K320A,K321A None None XRAY 2.14 0.189 0.229 A 310 300 4 0 0 0 [[51, 317]] 1.0 4w9x OTHER_BMP2K_HUMAN NEK 4e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 4W9WA Q9NSY1 39 344 1161.0 YDJ:401,YDJ:402 Type1,Allosteric Active DFGin 6.364 13.405 BLAminus DFGAsp-rot-in -139.2, -173.86 58.9, 80.3 195.82, -2.87 -96.98, 16.54 297.28, 103.14 -77.9, -7.86 in-in in 8.894 Saltbr-in 2.721 HRD-in -69.75, -45.92 72.53, -3.24 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.8, -11.88 APE9-dihe-na -120.42, 166.14 APE8-dihe-in -109.12, 119.34 APE8-rot-in 297.36 APE67-dihe-in -66.84, -19.57 -44.6, -50.25 APE12-dist-in 12.077 APE11-dist-in 8.332 APE10-dist-in 4.184 APE9-dist-in 3.726 K320A,K321A None None XRAY 1.72 0.168 0.195 A 306 306 0 0 0 0 [[51, 317]] 1.0 4w9w OTHER_BMP2K_HUMAN NEK 3.8e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.981 12.01 BLAminus DFGAsp-rot-in -120.67, -179.49 71.42, 87.57 193.53, -7.96 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.796 Saltbr-in 2.914 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.725 APE11-dist-out 14.148 APE10-dist-out 10.635 APE9-dist-out 10.792 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356 329 15 0 0 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 4e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.101 12.046 BLAminus DFGAsp-rot-in -119.58, -176.38 67.12, 86.64 185.49, 6.11 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.772 Saltbr-in 2.901 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.697 APE11-dist-out 14.062 APE10-dist-out 10.116 APE9-dist-out 11.022 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356 328 14 0 0 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 4e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.122 11.829 BLAminus DFGAsp-rot-in -125.96, -174.79 66.73, 90.85 193.09, -10.22 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.711 Saltbr-in 2.874 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.744 APE11-dist-out 16.324 APE10-dist-out 13.204 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365 332 16 0 0 0 [[787, 1056]] 1.0 4r8q OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.068 BLAminus DFGAsp-rot-in -133.45, -169.91 60.82, 85.13 199.56, -11.31 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.701 Saltbr-out 3.764 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.785 APE11-dist-out 16.036 APE10-dist-out 12.54 APE9-dist-in 5.943 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.22 11.852 BLAminus DFGAsp-rot-in -128.64, -170.27 62.18, 89.46 200.83, -8.26 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.572 Saltbr-out 4.025 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.575 APE11-dist-out 15.552 APE10-dist-out 12.266 APE9-dist-in 5.742 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN AF-O43683-K1A O43683 779 1064 1085.0 No_ligand No_ligand Inactive DFGin 4.887 12.545 BLAminus DFGAsp-rot-in -124.11, 170.92 65.03, 81.73 202.07, 5.03 -91.31, 15.98 298.54, 164.44 -67.14, -23.03 in-in in 8.046 Saltbr-in 2.67 HRD-in -69.05, -45.13 83.02, -19.12 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.71, 136.7 APE9-dihe-na -69.9, -23.95 APE8-dihe-in -86.83, 108.84 APE8-rot-in 313.14 APE67-dihe-in -72.66, -10.25 -53.96, -32.87 APE12-dist-in 11.466 APE11-dist-out 14.215 APE10-dist-out 10.259 APE9-dist-out 11.411 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[787, 1056]] 1.0 AF-O43683-K1 OTHER_BUB1_HUMAN BUB 1.8e-136 459.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN AF-O43683-K3A O43683 779 1064 1085.0 No_ligand No_ligand Active DFGin 5.075 11.864 BLAminus DFGAsp-rot-in -128.54, -179.59 61.18, 57.25 201.6, 27.47 -71.97, 12.64 306.02, 171.57 -71.12, -26.04 in-in in 7.607 Saltbr-in 2.673 HRD-in -71.31, -42.36 83.29, -4.71 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -66.95, 155.76 APE9-dihe-na -65.62, -39.37 APE8-dihe-in -84.2, 100.84 APE8-rot-in 321.71 APE67-dihe-in -71.04, -6.24 -56.45, -33.95 APE12-dist-in 11.484 APE11-dist-in 12.195 APE10-dist-in 6.713 APE9-dist-in 4.093 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[787, 1056]] 1.0 AF-O43683-K3 OTHER_BUB1_HUMAN BUB 1.8e-136 459.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 6F7BA O43683 733 1083 1085.0 CVQ:1101 Type1 Inactive DFGin 5.204 11.398 BLAminus DFGAsp-rot-in -126.36, -174.36 69.54, 95.46 197.32, -30.64 -102.79, 20.07 303.33, 2.4 -61.63, -33.57 in-in in 7.39 Saltbr-in 2.854 HRD-in -67.06, -52.34 92.92, -9.99 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -74.7, 171.94 APE9-dihe-na -80.48, 177.67 APE8-dihe-out -47.35, -47.06 APE8-rot-in 327.35 APE67-dihe-out -87.96, 156.59 -88.9, -3.15 APE12-dist-in 11.273 APE11-dist-in 13.096 APE10-dist-out 8.947 APE9-dist-out 8.054 None SEP969 SEP969 XRAY 2.0 0.201 0.254 A 361 343 8 0 0 0 [[787, 1056]] 1.0 6f7b OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus DFGAsp-rot-in -125.0, 176.56 71.88, 86.33 191.14, -10.66 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus DFGAsp-rot-in -128.61, 175.54 70.41, 87.99 191.32, -8.92 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus DFGAsp-rot-in -118.89, -178.58 68.69, 81.33 193.06, -3.59 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus DFGAsp-rot-in -126.02, 169.07 75.11, 84.03 194.62, -1.51 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus DFGAsp-rot-in -118.93, 173.08 76.34, 83.66 188.96, -2.47 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN AF-O00311-K1A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.95 14.177 BLAminus DFGAsp-rot-in -129.58, 170.96 66.26, 66.12 197.59, 20.89 -80.51, 16.59 285.96, 75.59 -64.0, -18.9 in-in in 9.043 Saltbr-in 2.647 HRD-in -70.08, -43.27 61.9, 11.94 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -57.06, 169.65 APE9-dihe-na -22.62, -165.28 APE8-dihe-in -75.42, 125.22 APE8-rot-in 295.02 APE67-dihe-inflip 114.52, -42.17 -51.79, 128.13 APE12-dist-in 7.28 APE11-dist-in 10.794 APE10-dist-in 6.853 APE9-dist-in 4.125 None None None AF2 -1.0 1.0 1.0 A 525 525 0 0 0 0 [[58, 569]] 1.0 AF-O00311-K1 OTHER_CDC7_HUMAN CAMK 1.9e-16 136.0 1 154 259 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN AF-O00311-K3A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.672 14.126 BLAminus DFGAsp-rot-in -130.86, 172.4 65.31, 69.78 197.55, 8.09 -80.97, 15.05 291.64, 76.67 -63.99, -19.66 in-in in 9.106 Saltbr-in 2.648 HRD-in -70.9, -38.36 68.14, -18.59 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -62.79, 152.01 APE9-dihe-na 121.05, 152.26 APE8-dihe-in -66.89, 133.21 APE8-rot-in 295.57 APE67-dihe-inflip 90.18, -22.02 -52.1, 138.77 APE12-dist-in 9.078 APE11-dist-in 11.232 APE10-dist-in 5.336 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 525 525 0 0 0 0 [[58, 569]] 1.0 AF-O00311-K3 OTHER_CDC7_HUMAN CAMK 1.9e-16 136.0 1 154 259 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.763 14.014 BLAminus DFGAsp-rot-in -127.87, 167.58 73.15, 98.39 210.16, -36.47 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.088 Saltbr-in 2.963 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361 318 38 0 0 17 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.596 14.137 BLAminus DFGAsp-rot-in -121.21, 173.13 67.81, 82.77 213.16, -38.5 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.886 Saltbr-in 2.749 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361 316 42 0 0 21 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.868 14.2 BLAminus DFGAsp-rot-in -130.13, 163.69 79.42, 87.08 198.91, -9.59 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.697 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361 306 48 0 0 26 [[58, 569]] 1.0 4f9c OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.683 14.123 BLAminus DFGAsp-rot-in -124.62, 164.87 81.15, 86.75 201.51, -13.15 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.653 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.586 None None None XRAY 1.44 0.168 0.193 A 359 340 12 0 0 12 [[58, 569]] 1.0 6ya6 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CHUK IKKA_HUMAN AF-O15111-K1A O15111 7 317 745.0 No_ligand No_ligand Active DFGin 5.704 12.09 BLAminus DFGAsp-rot-in -127.62, 177.04 62.52, 68.46 196.03, 22.32 -82.08, 19.91 301.08, 3.12 -65.11, -21.3 in-in in 8.279 Saltbr-in 2.599 HRD-in -74.14, -49.8 66.35, 2.91 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.32, 159.76 APE9-dihe-na 113.86, -177.42 APE8-dihe-in -101.61, 123.11 APE8-rot-in 299.17 APE67-dihe-in -65.21, -21.74 -44.12, -40.19 APE12-dist-in 8.574 APE11-dist-in 11.217 APE10-dist-in 5.335 APE9-dist-in 3.343 None None None AF2 -1.0 1.0 1.0 A 311 311 0 0 0 0 [[15, 294]] 1.0 AF-O15111-K1 OTHER_CHUK_HUMAN OTHER 9.2e-53 185.4 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN AF-O15111-K3A O15111 7 317 745.0 No_ligand No_ligand Active DFGin 5.793 12.319 BLAminus DFGAsp-rot-in -129.7, 178.58 58.9, 65.09 195.18, 26.45 -77.77, 19.68 299.27, 6.24 -65.69, -21.41 in-in in 8.238 Saltbr-in 2.618 HRD-in -75.09, -46.34 64.31, 13.49 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.99, 156.79 APE9-dihe-na 112.3, -173.76 APE8-dihe-in -103.27, 125.01 APE8-rot-in 297.57 APE67-dihe-in -71.46, -14.09 -48.66, -37.2 APE12-dist-in 8.266 APE11-dist-in 11.217 APE10-dist-in 5.322 APE9-dist-in 3.308 None None None AF2 -1.0 1.0 1.0 A 311 311 0 0 0 0 [[15, 294]] 1.0 AF-O15111-K3 OTHER_CHUK_HUMAN OTHER 9.2e-53 185.4 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZA O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.472 12.995 BLAminus DFGAsp-rot-in -157.9, 159.21 63.36, 117.08 181.84, 52.17 -127.05, 13.58 301.36, 131.68 -58.14, 0.46 in-out in 8.384 Saltbr-out 3.935 HRD-out -106.09, 98.92 -80.08, -31.47 out-in-out SNCoio in-out ActLoopNT-in 2.724 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiio APE10-dihe-na -133.13, -142.71 APE9-dihe-na -132.24, 138.03 APE8-dihe-out 32.05, 63.16 APE8-rot-out 173.72 APE67-dihe-out -166.38, -24.98 -61.08, 149.09 APE12-dist-in 9.604 APE11-dist-in 10.391 APE10-dist-in 7.45 APE9-dist-out 11.556 S176E,S180E None None XRAY 4.5 0.238 0.276 A 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZB O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.556 13.063 BLAminus DFGAsp-rot-in -157.87, 159.26 63.18, 117.0 181.73, 52.42 -127.43, 13.74 302.04, 131.95 -63.43, -5.84 in-out in 8.377 Saltbr-out 3.932 HRD-out -105.04, 98.56 -80.0, -30.69 out-in-out SNCoio in-out ActLoopNT-in 2.712 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -120.36, -131.93 APE9-dihe-na -142.0, 138.99 APE8-dihe-out 48.95, 36.51 APE8-rot-in 319.88 APE67-dihe-out -168.68, -36.55 -40.64, 144.07 APE12-dist-in 9.276 APE11-dist-in 10.073 APE10-dist-in 7.128 APE9-dist-out 11.466 S176E,S180E None None XRAY 4.5 0.238 0.276 B 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZC O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.349 12.937 BLAminus DFGAsp-rot-in -158.04, 158.83 63.52, 116.84 181.29, 51.64 -127.52, 13.57 301.17, 131.76 -63.04, -7.12 in-out in 8.378 Saltbr-out 3.924 HRD-out -105.78, 98.7 -80.36, -30.84 out-in-out SNCoio in-out ActLoopNT-in 3.083 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -114.04, -134.54 APE9-dihe-na -154.94, 140.93 APE8-dihe-out 52.3, 55.69 APE8-rot-in 310.3 APE67-dihe-inflip 179.0, -28.48 -76.67, 159.59 APE12-dist-in 8.462 APE11-dist-in 9.618 APE10-dist-in 6.882 APE9-dist-out 11.735 S176E,S180E None None XRAY 4.5 0.238 0.276 C 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZD O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.446 12.996 BLAminus DFGAsp-rot-in -157.99, 158.75 63.84, 116.89 181.5, 52.27 -127.2, 14.28 302.16, 131.35 -61.31, -3.61 in-out in 8.38 Saltbr-out 3.942 HRD-out -104.7, 98.61 -80.36, -30.78 out-in-out SNCoio in-out ActLoopNT-in 3.323 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiio APE10-dihe-na -114.92, -87.2 APE9-dihe-na 172.15, 150.56 APE8-dihe-out 44.69, 73.14 APE8-rot-out 59.12 APE67-dihe-out -173.33, -15.3 -88.22, 143.81 APE12-dist-in 9.76 APE11-dist-in 10.399 APE10-dist-in 6.858 APE9-dist-out 11.578 S176E,S180E None None XRAY 4.5 0.238 0.276 D 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZE O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.413 12.963 BLAminus DFGAsp-rot-in -157.88, 159.1 63.37, 117.32 181.66, 52.28 -127.83, 12.95 301.29, 131.92 -62.78, -6.6 in-out in 8.378 Saltbr-out 3.94 HRD-out -105.55, 98.72 -80.22, -30.93 out-in-out SNCoio in-out ActLoopNT-in 2.615 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -101.36, -137.17 APE9-dihe-na -137.48, 131.52 APE8-dihe-out 54.15, 65.61 APE8-rot-in 305.76 APE67-dihe-inflip 177.55, -22.94 -67.74, 156.35 APE12-dist-in 9.29 APE11-dist-in 10.41 APE10-dist-in 7.028 APE9-dist-out 11.537 S176E,S180E None None XRAY 4.5 0.238 0.276 E 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZF O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.554 12.956 BLAminus DFGAsp-rot-in -158.13, 160.12 61.88, 117.06 181.32, 53.41 -126.71, 13.37 301.67, 131.82 -61.28, -5.01 in-out in 8.368 Saltbr-out 3.921 HRD-out -104.83, 98.57 -80.32, -31.25 out-in-out SNCoio in-out ActLoopNT-in 2.648 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -133.95, -55.57 APE9-dihe-na 135.71, 126.78 APE8-dihe-out 52.92, 17.09 APE8-rot-in 348.87 APE67-dihe-out -130.03, -5.11 -48.71, 131.65 APE12-dist-in 9.462 APE11-dist-in 9.851 APE10-dist-in 7.027 APE9-dist-out 11.892 S176E,S180E None None XRAY 4.5 0.238 0.276 F 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZG O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.563 13.038 BLAminus DFGAsp-rot-in -157.79, 159.24 63.47, 116.86 181.68, 51.76 -127.13, 13.59 300.88, 131.93 -60.03, -2.91 in-out in 8.374 Saltbr-out 3.937 HRD-out -105.82, 98.69 -80.11, -31.24 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -105.14, -87.49 APE9-dihe-na -173.89, 131.61 APE8-dihe-out 42.38, 74.45 APE8-rot-in 310.05 APE67-dihe-out -155.35, -14.77 -78.11, 142.24 APE12-dist-in 8.133 APE11-dist-in 10.133 APE10-dist-in 7.365 APE9-dist-out 11.77 S176E,S180E None None XRAY 4.5 0.238 0.276 G 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZH O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.623 12.928 BLAminus DFGAsp-rot-in -157.82, 159.2 63.3, 117.1 182.19, 52.23 -127.62, 13.57 302.64, 131.85 -66.21, -13.0 in-out in 8.378 Saltbr-out 3.921 HRD-out -105.33, 98.48 -79.98, -30.79 out-in-out SNCoio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -120.33, -132.08 APE9-dihe-na -135.18, 141.74 APE8-dihe-out 53.01, 41.79 APE8-rot-in 318.66 APE67-dihe-out -179.07, -65.81 -56.31, 151.34 APE12-dist-in 9.028 APE11-dist-in 10.229 APE10-dist-in 6.71 APE9-dist-out 11.904 S176E,S180E None None XRAY 4.5 0.238 0.276 H 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZI O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.447 12.905 BLAminus DFGAsp-rot-in -158.21, 159.53 62.55, 117.44 181.19, 51.85 -127.53, 13.64 301.73, 131.69 -61.68, -3.37 in-out in 8.378 Saltbr-out 3.928 HRD-out -105.58, 98.9 -80.55, -30.56 out-in-out SNCoio in-out ActLoopNT-in 2.614 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -123.2, -168.23 APE9-dihe-na -65.65, -161.64 APE8-dihe-in -47.13, 90.76 APE8-rot-in 294.26 APE67-dihe-out -155.06, -11.93 -74.74, 142.39 APE12-dist-in 7.733 APE11-dist-in 9.24 APE10-dist-in 7.259 APE9-dist-out 12.113 S176E,S180E None None XRAY 4.5 0.238 0.276 I 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZJ O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.457 13.035 BLAminus DFGAsp-rot-in -158.14, 158.87 63.49, 116.94 181.48, 52.74 -127.22, 13.75 301.97, 131.59 -63.14, -6.87 in-out in 8.378 Saltbr-out 3.95 HRD-out -104.47, 97.82 -79.51, -30.99 out-in-out SNCoio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -134.95, -77.48 APE9-dihe-na 163.8, 138.53 APE8-dihe-out 51.98, 77.04 APE8-rot-in 309.05 APE67-dihe-out -176.04, -11.28 -80.48, 141.14 APE12-dist-in 8.844 APE11-dist-in 9.965 APE10-dist-in 6.813 APE9-dist-out 11.672 S176E,S180E None None XRAY 4.5 0.238 0.276 J 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZK O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.446 12.97 BLAminus DFGAsp-rot-in -158.43, 159.6 63.23, 117.12 181.6, 52.38 -127.98, 13.19 301.21, 131.48 -63.15, -8.18 in-out in 8.379 Saltbr-out 3.906 HRD-out -105.38, 98.71 -80.39, -31.17 out-in-out SNCoio in-out ActLoopNT-in 2.584 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -113.74, -140.48 APE9-dihe-na -132.51, 126.65 APE8-dihe-out 53.41, 74.49 APE8-rot-in 305.2 APE67-dihe-inflip 170.32, -23.62 -76.67, 162.92 APE12-dist-in 8.511 APE11-dist-in 10.095 APE10-dist-in 7.401 APE9-dist-out 11.867 S176E,S180E None None XRAY 4.5 0.238 0.276 K 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZL O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.521 12.989 BLAminus DFGAsp-rot-in -158.24, 159.63 62.65, 117.16 181.43, 52.8 -127.45, 13.49 301.65, 131.79 -64.73, -7.71 in-out in 8.372 Saltbr-out 3.931 HRD-out -104.64, 98.46 -80.27, -31.08 out-in-out SNCoio in-out ActLoopNT-in 2.617 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -118.73, -95.08 APE9-dihe-na -177.7, 127.99 APE8-dihe-out 49.93, 69.03 APE8-rot-in 331.03 APE67-dihe-out -153.57, -29.29 -80.56, 145.25 APE12-dist-in 9.335 APE11-dist-in 10.03 APE10-dist-in 6.77 APE9-dist-out 11.862 S176E,S180E None None XRAY 4.5 0.238 0.276 L 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQWA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -121.53, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.695 Saltbr-in 2.516 HRD-in -73.2, -34.98 65.9, 2.16 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.08, -10.54 999.0, -7.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.6 999.0 999.0 A 655 564 59 0 0 20 [[15, 294]] 1.0 5tqw OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQWB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -121.68, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.693 Saltbr-in 2.517 HRD-in -73.21, -34.93 65.98, 2.06 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.08, -10.48 999.0, -7.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.6 999.0 999.0 B 655 564 59 0 0 20 [[15, 294]] 1.0 5tqw OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQXA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -93.75, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.51 Saltbr-out 4.44 HRD-in -71.13, -57.89 73.32, -12.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.71 APE8-rot-in 303.99 APE67-dihe-in -76.84, -13.71 -97.01, -2.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.4 999.0 999.0 A 655 563 54 0 0 19 [[15, 294]] 1.0 5tqx OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQXB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -93.81, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.51 Saltbr-out 4.44 HRD-in -71.08, -57.92 73.39, -12.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.81 APE8-rot-in 303.97 APE67-dihe-in -76.86, -13.71 -97.1, -2.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.4 999.0 999.0 B 655 563 54 0 0 19 [[15, 294]] 1.0 5tqx OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQYA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -144.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.281 Saltbr-out 4.528 HRD-in -72.53, -37.92 60.97, 11.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.38 APE8-rot-in 301.07 APE67-dihe-in -70.69, -23.59 -103.74, -19.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.2 999.0 999.0 A 655 578 54 0 0 19 [[15, 294]] 1.0 5tqy OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQYB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -144.13, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.279 Saltbr-out 4.527 HRD-in -72.66, -37.87 60.82, 11.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.32 APE8-rot-in 301.16 APE67-dihe-in -70.79, -23.46 -103.64, -19.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.2 999.0 999.0 B 655 578 54 0 0 19 [[15, 294]] 1.0 5tqy OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER DSTYK DUSTY_HUMAN AF-Q6XUX3-K1A Q6XUX3 644 916 929.0 No_ligand No_ligand Active DFGin 5.525 12.5 BLAminus DFGAsp-rot-in -135.67, 179.03 67.7, 62.8 200.07, 17.92 -81.0, 10.29 308.22, 7.96 -62.27, -25.9 in-in in 7.924 Saltbr-in 2.675 HRD-in -75.72, -44.19 63.93, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 165.0 APE9-dihe-na 103.92, -178.75 APE8-dihe-in -87.6, 119.49 APE8-rot-in 302.61 APE67-dihe-in -66.26, -22.08 -47.21, -45.97 APE12-dist-in 8.664 APE11-dist-in 11.304 APE10-dist-in 5.516 APE9-dist-in 3.575 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[650, 908]] 1.0 AF-Q6XUX3-K1 OTHER_DSTYK_HUMAN TKL 4.5e-37 134.0 4 265 262 794 795 796 798 800 681 697 701 774 776 775 777 830 819 814 813 812 811 810 809 808 735 Dual serine/threonine and tyrosine protein kinase
OTHER DSTYK DUSTY_HUMAN AF-Q6XUX3-K3A Q6XUX3 644 916 929.0 No_ligand No_ligand Active DFGin 5.506 12.526 BLAminus DFGAsp-rot-in -132.96, 175.33 65.47, 65.66 198.45, 21.81 -74.76, 15.89 304.88, 8.41 -60.99, -23.72 in-in in 8.906 Saltbr-in 2.689 HRD-in -76.85, -43.91 65.27, 12.2 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.43, 159.06 APE9-dihe-na 120.99, 175.91 APE8-dihe-in -84.2, 123.32 APE8-rot-in 299.52 APE67-dihe-in -64.52, -20.37 -51.46, -48.2 APE12-dist-in 8.578 APE11-dist-in 11.601 APE10-dist-in 5.723 APE9-dist-in 3.444 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[650, 908]] 1.0 AF-Q6XUX3-K3 OTHER_DSTYK_HUMAN TKL 4.5e-37 134.0 4 265 262 794 795 796 798 800 681 697 701 774 776 775 777 830 819 814 813 812 811 810 809 808 735 Dual serine/threonine and tyrosine protein kinase
OTHER EIF2AK1 E2AK1_HUMAN AF-Q9BQI3-K1A Q9BQI3 159 591 630.0 No_ligand No_ligand Active DFGin 6.467 14.562 BLAminus DFGAsp-rot-in -131.92, -174.96 56.89, 76.47 193.78, 24.76 -88.07, 19.13 289.41, 80.9 -58.96, -27.63 in-in in 8.537 Saltbr-in 2.718 HRD-in -71.02, -44.85 67.31, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.67, 162.49 APE9-dihe-na 93.82, 165.11 APE8-dihe-in -70.82, 124.42 APE8-rot-in 291.15 APE67-dihe-in -57.27, -28.02 -49.56, -44.59 APE12-dist-in 9.1 APE11-dist-in 11.857 APE10-dist-in 5.935 APE9-dist-in 3.646 None None None AF2 -1.0 1.0 1.0 A 433 433 0 0 0 0 [[48, 583]] 1.0 AF-Q9BQI3-K1 OTHER_EIF2AK1_HUMAN OTHER 1.2e-45 162.1 1 257 257 460 461 462 464 466 196 214 218 439 441 440 442 512 500 495 494 493 492 491 490 489 385 Eukaryotic translation initiation factor 2-alpha kinase 1
OTHER EIF2AK1 E2AK1_HUMAN AF-Q9BQI3-K3A Q9BQI3 159 591 630.0 No_ligand No_ligand Active DFGin 6.361 14.345 BLAminus DFGAsp-rot-in -137.24, -170.89 57.0, 58.15 193.79, 30.25 -73.48, 14.84 291.76, 88.74 -60.41, -27.06 in-in in 7.764 Saltbr-in 2.688 HRD-in -75.49, -42.3 67.07, -9.68 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.29, 159.56 APE9-dihe-na 101.23, 170.11 APE8-dihe-in -77.19, 124.48 APE8-rot-in 287.94 APE67-dihe-in -60.9, -28.79 -48.13, -43.53 APE12-dist-in 9.105 APE11-dist-in 11.94 APE10-dist-in 5.966 APE9-dist-in 3.402 None None None AF2 -1.0 1.0 1.0 A 433 433 0 0 0 0 [[48, 583]] 1.0 AF-Q9BQI3-K3 OTHER_EIF2AK1_HUMAN OTHER 1.2e-45 162.1 1 257 257 460 461 462 464 466 196 214 218 439 441 440 442 512 500 495 494 493 492 491 490 489 385 Eukaryotic translation initiation factor 2-alpha kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.285 14.335 ABAminus DFGAsp-rot-in -120.94, -28.83 -115.8, 107.84 178.61, -4.62 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.248 Saltbr-in 2.731 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.545 APE11-dist-in 10.841 APE10-dist-out 10.336 APE9-dist-out 9.852 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284 262 9 0 0 0 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.941 14.558 ABAminus DFGAsp-rot-in -118.27, -31.05 -99.56, 112.7 206.74, -13.64 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.696 Saltbr-in 3.422 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284 202 69 0 0 22 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A1AB P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.258 14.04 ABAminus DFGAsp-rot-in -132.54, 38.21 -152.54, 121.76 182.44, -61.28 -125.72, 22.12 289.52, 72.9 -59.14, -10.25 in-in in 8.628 Saltbr-in 2.676 HRD-out -113.12, 112.61 -109.71, 52.22 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -135.52, 146.24 APE9-dihe-na 84.2, -133.27 APE8-dihe-in -88.04, 112.57 APE8-rot-out 53.95 APE67-dihe-out -49.6, 148.63 -66.06, -24.41 APE12-dist-in 12.721 APE11-dist-in 10.235 APE10-dist-out 9.499 APE9-dist-out 9.747 H412N,C551A TPO446 TPO446 XRAY 2.8 0.213 0.268 B 284 267 4 0 0 0 [[175, 537]] 1.0 2a1a OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 8QELB P19525 258 541 551.0 UH3:64000 Type1 Inactive DFGin 6.691 13.817 ABAminus DFGAsp-rot-in -110.21, -37.78 -88.63, 117.61 196.31, -68.21 -118.7, 28.42 293.93, 84.05 -65.21, -26.2 in-in in 8.639 Saltbr-in 3.087 HRD-in -74.4, -47.11 71.83, -9.65 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -148.0, 101.41 APE9-dihe-na -176.3, -150.32 APE8-dihe-out -87.07, -2.65 APE8-rot-out 19.95 APE67-dihe-out -74.94, -36.92 29.55, 28.82 APE12-dist-in 12.883 APE11-dist-in 10.587 APE10-dist-out 11.133 APE9-dist-out 9.144 None TPO446 TPO446 XRAY 2.451 0.243 0.278 B 273 265 0 0 0 0 [[175, 537]] 1.0 8qel OTHER_EIF2AK2_HUMAN OTHER 5.5e-47 166.5 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.192 14.114 BLAminus DFGAsp-rot-in -129.83, -165.99 54.1, 79.73 201.48, -12.86 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.721 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323 258 31 0 0 10 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.393 14.221 BLAminus DFGAsp-rot-in -124.42, -164.03 49.77, 78.4 198.3, 27.26 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.57 Saltbr-in 2.966 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323 254 33 0 0 11 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.312 14.466 BLAminus DFGAsp-rot-in -121.59, -161.34 59.64, 70.11 199.97, -2.68 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.513 Saltbr-in 2.676 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.194 None None None XRAY 2.6 0.212 0.266 C 323 258 27 0 0 3 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN AF-P19525-K1A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.333 13.834 BLAminus DFGAsp-rot-in -132.8, -166.15 52.16, 75.52 192.27, 27.15 -88.26, 20.77 290.79, 85.32 -63.1, -19.58 in-in in 8.478 Saltbr-in 2.736 HRD-in -72.57, -46.6 69.03, -13.92 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.51, 128.47 APE9-dihe-na 130.95, 179.51 APE8-dihe-in -75.68, 113.45 APE8-rot-in 288.39 APE67-dihe-in -56.2, -32.95 -49.38, -38.3 APE12-dist-in 12.505 APE11-dist-in 12.584 APE10-dist-in 6.947 APE9-dist-in 4.405 None None None AF2 -1.0 1.0 1.0 A 288 288 0 0 0 0 [[175, 537]] 1.0 AF-P19525-K1 OTHER_EIF2AK2_HUMAN OTHER 2.4e-49 174.3 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN AF-P19525-K3A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.437 14.688 BLAminus DFGAsp-rot-in -132.88, -162.16 46.57, 66.9 192.82, 16.79 -77.63, 15.78 288.57, 86.29 -62.83, -24.06 in-in in 8.245 Saltbr-in 2.727 HRD-in -72.61, -45.07 68.66, -19.19 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.26, 124.49 APE9-dihe-na 137.76, -176.2 APE8-dihe-in -86.4, 108.58 APE8-rot-in 306.54 APE67-dihe-in -53.8, -42.4 -49.39, -37.75 APE12-dist-in 12.581 APE11-dist-in 12.645 APE10-dist-in 7.186 APE9-dist-in 4.589 None None None AF2 -1.0 1.0 1.0 A 288 288 0 0 0 0 [[175, 537]] 1.0 AF-P19525-K3 OTHER_EIF2AK2_HUMAN OTHER 2.4e-49 174.3 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.428 13.548 None DFGAsp-rot-in -156.44, 50.2 -150.13, 79.38 189.81, 66.6 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.25 Saltbr-out 4.208 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.893 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323 248 36 0 0 17 [[175, 537]] 1.0 6d3l OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.617 12.224 None DFGAsp-rot-in 179.67, 47.65 -88.7, 86.35 174.89, -87.02 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.54 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306 255 33 0 0 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.4e-48 170.6 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.613 12.222 None DFGAsp-rot-in 179.62, 47.59 -88.43, 86.11 174.81, -86.51 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.534 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306 255 33 0 0 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.4e-48 170.6 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K1A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.869 13.858 BLAminus DFGAsp-rot-in -144.99, -173.94 54.37, 67.55 195.8, 29.23 -75.34, 20.54 292.33, 90.53 -60.73, -19.34 in-in in 9.132 Saltbr-in 2.703 HRD-in -81.34, -41.96 64.36, -15.0 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.8, 151.1 APE9-dihe-na 99.93, 176.91 APE8-dihe-in -81.29, 119.6 APE8-rot-in 301.9 APE67-dihe-in -78.31, -22.78 -45.12, -27.42 APE12-dist-in 11.098 APE11-dist-in 12.405 APE10-dist-in 6.445 APE9-dist-in 3.677 None None None AF2 -1.0 1.0 1.0 A 501 501 0 0 0 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K1 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K3A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.608 13.733 BLAminus DFGAsp-rot-in -140.91, -171.67 54.11, 63.74 192.44, 25.28 -75.27, 21.29 296.22, 91.12 -60.87, -20.0 in-in in 8.242 Saltbr-in 2.671 HRD-in -80.93, -43.84 66.73, -9.25 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.59, 135.8 APE9-dihe-na 120.91, -171.05 APE8-dihe-in -91.04, 118.7 APE8-rot-in 298.86 APE67-dihe-in -66.86, -27.92 -47.06, -34.99 APE12-dist-in 11.278 APE11-dist-in 12.376 APE10-dist-in 6.478 APE9-dist-in 3.488 None None None AF2 -1.0 1.0 1.0 A 501 501 0 0 0 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K3 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.341 13.643 None DFGAsp-rot-in -94.22, -155.12 -53.25, 136.69 200.25, -7.41 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.524 Saltbr-out 8.569 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317 246 46 0 0 29 [[593, 1077]] 1.0 4x7o OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.095 13.784 None DFGAsp-rot-in -77.51, -156.87 -60.47, 147.45 210.9, -12.28 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.728 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317 259 31 0 0 27 [[593, 1077]] 1.0 7mf0 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.342 None DFGAsp-rot-in -89.55, -152.51 -63.21, 140.56 205.29, 2.12 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.699 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317 253 38 0 0 27 [[593, 1077]] 1.0 8eq9 OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.511 13.393 None DFGAsp-rot-in -76.6, -162.05 -50.39, 140.83 192.64, 5.81 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.954 Saltbr-out 8.092 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317 256 35 0 0 25 [[593, 1077]] 1.0 8eqd OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.232 13.832 None DFGAsp-rot-in -84.54, -159.02 -56.0, 133.56 191.31, 12.36 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.061 Saltbr-out 9.7 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.304 None None None XRAY 2.28 0.205 0.242 A 299 247 38 0 0 26 [[593, 1077]] 1.0 4g31 OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.68 None DFGAsp-rot-in -82.87, -161.08 -56.81, 138.38 196.42, 9.09 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.692 Saltbr-out 9.767 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 None None None XRAY 2.7 0.21 0.258 A 299 247 37 0 0 27 [[593, 1077]] 1.0 4g34 OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.029 13.826 None DFGAsp-rot-in -84.66, -156.85 -61.94, 137.1 187.96, 19.34 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.789 Saltbr-out 10.758 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.135 None None None XRAY 2.34 0.209 0.282 A 299 246 39 0 0 26 [[593, 1077]] 1.0 4m7i OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.201 13.869 None DFGAsp-rot-in -81.55, -152.92 -57.14, 146.2 197.5, 2.52 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.231 Saltbr-out 9.153 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.818 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317 256 35 0 0 26 [[593, 1077]] 1.0 8eqe OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7JA Q9NZJ5 585 1086 1116.0 3Z1:1101 Type1 Inactive DFGout 12.646 11.746 BBAminus DFGAsp-rot-in -176.98, -166.74 -114.82, 83.88 172.95, 30.26 -76.24, -41.23 290.33, 81.74 65.53, 38.29 out-out out 11.617 Saltbr-out 8.252 HRD-in -69.35, -52.51 78.62, -22.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.01, -22.0 999.0, 154.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.3 0.196 0.225 A 317 257 40 0 0 28 [[593, 1077]] 1.0 4x7j OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7KA Q9NZJ5 585 1087 1116.0 3Z3:1101 Type2 Inactive DFGout 12.544 11.365 BBAminus DFGAsp-rot-in -164.33, -167.96 -113.88, 89.92 182.35, -2.4 -77.28, -42.74 283.96, 78.23 66.26, 40.59 out-out out 11.511 Saltbr-out 9.706 HRD-in -84.11, -56.75 85.81, -21.5 out-out-out SNCooo out-out ActLoopNT-out 21.153 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.05 APE8-rot-out 179.62 APE67-dihe-in -59.37, -28.86 -109.52, 8.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.8 0.177 0.196 A 317 260 38 0 0 26 [[593, 1077]] 1.0 4x7k OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7LA Q9NZJ5 585 1087 1116.0 3Z4:1101 Type2 Inactive DFGout 12.642 11.31 BBAminus DFGAsp-rot-in -164.8, -167.28 -114.04, 88.17 182.01, -4.16 -74.87, -43.18 282.08, 78.75 64.58, 42.25 out-out out 11.456 Saltbr-out 9.844 HRD-in -84.66, -55.97 85.16, -23.49 out-out-out SNCooo out-out ActLoopNT-out 20.918 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.96 APE8-rot-out 184.8 APE67-dihe-in -58.09, -32.47 -109.67, 8.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.9 0.172 0.193 A 317 260 38 0 0 26 [[593, 1077]] 1.0 4x7l OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7NA Q9NZJ5 585 1087 1116.0 3Z5:1101 Type2 Inactive DFGout 12.624 11.336 BBAminus DFGAsp-rot-in -159.96, -166.6 -113.91, 86.84 181.7, -15.18 -73.68, -38.78 284.48, 77.45 62.04, 46.12 out-out out 11.466 Saltbr-out 9.77 HRD-in -89.68, -53.93 84.75, -24.71 out-out-out SNCooo out-out ActLoopNT-out 21.103 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.8 APE8-rot-out 184.51 APE67-dihe-in -64.57, -30.33 -109.92, 11.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.35 0.211 0.245 A 317 259 39 0 0 26 [[593, 1077]] 1.0 4x7n OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7HA Q9NZJ5 585 1086 1116.0 3Z2:1101 Type2 Inactive DFGout 16.988 7.988 None DFGAsp-rot-in -147.44, -164.97 -147.31, 104.14 185.0, 27.01 -56.25, -41.74 188.75, 74.74 -79.36, 999.0 out-out out 11.692 Saltbr-out 7.361 HRD-in -84.56, -56.41 85.91, -24.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.13 APE8-rot-in 311.97 APE67-dihe-in -61.01, -23.09 -108.5, -0.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.0 0.202 0.214 A 317 256 41 0 0 29 [[593, 1077]] 1.0 4x7h OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K2A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.617 14.333 BLAminus DFGAsp-rot-in -136.29, -175.54 55.03, 79.43 198.56, 25.07 -90.03, 22.0 290.92, 79.21 -58.96, -26.48 in-in in 9.506 Saltbr-in 2.949 HRD-in -71.79, -47.78 64.97, -9.83 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.06, 154.72 APE9-dihe-na 104.42, 174.21 APE8-dihe-in -78.42, 122.57 APE8-rot-in 303.04 APE67-dihe-in -70.42, -29.98 -45.44, -33.85 APE12-dist-in 11.12 APE11-dist-in 11.892 APE10-dist-in 5.918 APE9-dist-in 3.736 None None None AF2 -1.0 1.0 1.0 A 428 428 0 0 0 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K2 OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K4A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.606 13.998 BLAminus DFGAsp-rot-in -136.5, -169.45 54.98, 63.3 208.76, -0.23 -76.1, 15.72 292.56, 86.18 -62.07, -22.72 in-in in 8.808 Saltbr-in 2.746 HRD-in -75.42, -42.82 64.6, -12.86 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.36, 139.51 APE9-dihe-na 113.38, 169.46 APE8-dihe-in -72.14, 130.61 APE8-rot-in 295.69 APE67-dihe-in -77.95, -5.75 -49.91, -35.42 APE12-dist-in 11.068 APE11-dist-in 11.931 APE10-dist-in 6.15 APE9-dist-in 3.359 None None None AF2 -1.0 1.0 1.0 A 428 428 0 0 0 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K4 OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3NA Q9P2K8 584 1003 1649.0 KA4:62500 Type1 Inactive DFGin 6.942 14.896 BLAminus DFGAsp-rot-out -161.77, -164.95 51.61, 53.4 268.54, -60.79 -59.48, -46.57 276.83, 65.68 113.21, 101.52 out-out out 11.833 Saltbr-out 11.498 HRD-in -82.81, -56.02 77.87, -40.32 out-out-none SNCoon out-none ActLoopNT-out 8.528 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 6.58 APE8-rot-na 302.93 APE67-dihe-in -70.39, -29.28 -70.81, -30.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 3.01 0.219 0.277 A 317 242 55 0 0 27 [[277, 541], [590, 1001]] 2.0 6n3n OTHER_EIF2AK4-2_HUMAN OTHER 2.5e-45 161.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3OA Q9P2K8 584 1004 1649.0 KA7:62500 Type1.5_Back Inactive DFGin 6.652 15.208 BLAminus DFGAsp-rot-out -153.67, -168.18 56.94, 54.84 276.99, -31.06 -57.06, -41.03 283.3, 70.25 96.81, 112.56 out-out out 12.227 Saltbr-out 12.581 HRD-in -73.69, -58.26 76.04, -15.13 out-out-none SNCoon out-none ActLoopNT-out 8.658 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.04 APE8-rot-na 294.34 APE67-dihe-in -83.15, -13.22 -77.59, -5.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 2.4 0.202 0.254 A 317 252 46 0 0 26 [[277, 541], [590, 1001]] 2.0 6n3o OTHER_EIF2AK4-2_HUMAN OTHER 2.5e-45 161.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.545 13.832 None DFGAsp-rot-out -64.42, 179.79 -78.36, -177.52 69.56, -51.49 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.404 Saltbr-out 7.228 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.309 D848N None None XRAY 2.8 0.213 0.258 A 320 269 26 0 0 20 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.743 14.437 None DFGAsp-rot-out -62.22, 177.25 -71.17, -177.31 71.08, -57.72 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.63 Saltbr-out 6.773 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.808 APE11-dist-out 18.791 APE10-dist-out 18.981 APE9-dist-out 12.646 D848N None None XRAY 2.8 0.213 0.258 B 320 275 22 0 0 18 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.153 15.331 None DFGAsp-rot-out -67.88, 178.26 -74.84, 168.69 62.03, -44.97 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.431 Saltbr-out 6.787 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.73 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 D848N None None XRAY 2.8 0.213 0.258 C 320 267 30 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.793 14.782 None DFGAsp-rot-out -71.0, 172.41 -73.73, 163.04 64.81, -29.71 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.102 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.505 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320 260 37 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.037 8.181 None DFGAsp-rot-out -60.18, 141.19 -134.64, 94.13 42.41, 13.86 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.114 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.748 APE10-dist-out 24.316 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318 254 42 0 0 24 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKA Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.824 9.513 None DFGAsp-rot-none -134.51, -151.1 -121.46, -46.25 999.0, 999.0 35.17, 27.68 228.21, 155.53 -84.53, 128.11 out-none out 11.558 Saltbr-none 999.0 HRD-in -76.45, -48.97 72.32, -6.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.65 APE8-dihe-out -87.38, 8.98 APE8-rot-none 999.0 APE67-dihe-in -67.63, -12.84 -66.2, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.282 D848N None None XRAY 2.3 0.214 0.243 A 318 245 48 0 0 33 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKB Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.844 9.39 None DFGAsp-rot-in -144.52, -139.04 -156.42, 125.77 162.38, 78.01 -114.71, 16.01 223.02, 149.14 -71.92, 114.82 out-out out 11.848 Saltbr-out 8.195 HRD-in -79.04, -54.75 67.92, 8.38 out-out-out SNCooo out-out ActLoopNT-out 14.534 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.73 APE8-dihe-out -76.87, -29.31 APE8-rot-none 999.0 APE67-dihe-in -63.87, -23.61 -70.02, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.868 D848N None None XRAY 2.3 0.214 0.243 B 318 249 44 0 0 26 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKC Q9P2K8 583 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.942 9.721 None DFGAsp-rot-in -140.22, -142.02 -158.37, 117.76 168.26, 58.25 -96.27, -4.59 219.72, 151.65 -71.27, 106.76 out-out out 11.963 Saltbr-out 7.857 HRD-in -88.1, -52.43 58.54, 27.47 out-out-none SNCoon out-none ActLoopNT-out 15.315 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -59.9 APE8-rot-none 999.0 APE67-dihe-in -67.01, -4.12 -84.11, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 C 318 249 47 0 0 30 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKD Q9P2K8 583 1003 1649.0 G41:1701 Type1 Inactive DFGout 17.703 9.322 None DFGAsp-rot-in -139.27, -135.78 -159.12, 124.73 166.01, 54.36 -118.38, 23.17 221.49, 144.06 -75.45, 126.8 out-out out 11.834 Saltbr-out 8.431 HRD-in -88.04, -58.27 56.71, 45.95 out-out-out SNCooo out-out ActLoopNT-out 14.749 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.87 APE8-dihe-out -67.23, -22.9 APE8-rot-none 999.0 APE67-dihe-in -74.1, -19.72 -68.07, -8.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.557 D848N None None XRAY 2.3 0.214 0.243 D 318 254 41 0 0 27 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKE Q9P2K8 584 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.779 9.822 None DFGAsp-rot-in -151.76, -141.6 -160.26, 136.01 209.3, -77.46 -98.22, 91.17 239.64, 115.15 -107.96, 84.44 out-none out 11.082 Saltbr-none 999.0 HRD-in -88.02, -51.01 74.43, -13.48 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 E 318 241 54 0 0 42 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKG Q9P2K8 584 1007 1649.0 G41:1701 Type1 Inactive DFGout 18.192 10.134 None DFGAsp-rot-in -152.52, -143.94 -140.15, -46.73 208.16, -84.46 82.87, -54.7 218.3, 133.54 -74.32, 999.0 out-out out 11.658 Saltbr-out 9.2 HRD-in -81.42, -58.02 87.03, -25.33 out-out-none SNCoon out-none ActLoopNT-out 6.618 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -52.87 APE8-rot-none 999.0 APE67-dihe-in -65.85, -22.5 -65.49, -20.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 G 318 257 41 0 0 26 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LA Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.724 8.694 None DFGAsp-rot-in -131.92, -171.74 -165.1, 131.81 183.34, 17.34 -91.39, 999.0 282.47, 16.23 999.0, 999.0 in-in in 8.375 Saltbr-in 3.222 HRD-in -61.96, -55.14 81.8, -15.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.98 APE8-rot-none 999.0 APE67-dihe-in -81.86, -12.43 -63.68, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 A 330 230 65 0 0 36 [[277, 541], [590, 1001]] 2.0 6n3l OTHER_EIF2AK4-2_HUMAN OTHER 3.9e-45 160.5 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LB Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.445 8.619 None DFGAsp-rot-in -134.73, -168.42 -167.35, 133.28 182.98, 14.8 -92.51, 999.0 285.34, 13.72 999.0, 999.0 in-in in 8.388 Saltbr-in 3.482 HRD-in -61.97, -53.58 83.5, -20.28 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.86 APE8-rot-none 999.0 APE67-dihe-in -82.56, -10.84 -61.36, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 B 330 227 68 0 0 36 [[277, 541], [590, 1001]] 2.0 6n3l OTHER_EIF2AK4-2_HUMAN OTHER 3.9e-45 160.5 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4Z7HB O75460 562 962 977.0 4L5:1001 Type1 Inactive DFGin 5.135 14.518 ABAminus DFGAsp-rot-in -147.31, -25.96 -101.01, 93.63 209.01, -20.67 -84.21, 0.58 280.19, 77.98 -61.73, -35.98 in-in in 8.295 Saltbr-in 2.88 HRD-in -73.65, -45.51 64.99, 2.13 in-in-out SNCiio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -82.39, -0.49 APE9-dihe-na 151.41, -152.92 APE8-dihe-in -124.62, 124.86 APE8-rot-out 45.76 APE67-dihe-inflip 103.66, -22.96 -54.37, 143.35 APE12-dist-none 999.0 APE11-dist-in 8.436 APE10-dist-out 8.736 APE9-dist-in 4.695 None None None XRAY 2.9 0.202 0.225 B 416 388 13 0 0 7 [[571, 832]] 1.0 4z7h OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN AF-O75460-K1A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.226 14.358 BLAminus DFGAsp-rot-in -136.1, 174.69 62.75, 82.9 195.21, 16.75 -90.11, 8.09 278.92, 58.01 -56.59, -35.42 in-in in 8.623 Saltbr-in 2.739 HRD-in -70.55, -49.28 65.1, -0.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.61, 153.38 APE9-dihe-na 118.83, 174.73 APE8-dihe-in -98.29, 131.32 APE8-rot-in 303.59 APE67-dihe-inflip 83.09, -9.62 -47.44, 134.97 APE12-dist-in 10.873 APE11-dist-in 11.147 APE10-dist-in 5.238 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[571, 832]] 1.0 AF-O75460-K1 OTHER_ERN1_HUMAN CAMK 8.5e-36 129.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN AF-O75460-K3A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.249 14.149 BLAminus DFGAsp-rot-in -135.31, -174.96 58.8, 76.05 198.78, 24.44 -86.75, 1.33 278.92, 66.56 -57.5, -35.04 in-in in 8.461 Saltbr-in 2.679 HRD-in -73.71, -47.28 67.17, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.31, 152.38 APE9-dihe-na 117.01, 175.14 APE8-dihe-in -93.16, 133.21 APE8-rot-in 303.49 APE67-dihe-inflip 79.17, -0.04 -48.5, 133.79 APE12-dist-in 10.894 APE11-dist-in 11.197 APE10-dist-in 5.303 APE9-dist-in 3.42 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[571, 832]] 1.0 AF-O75460-K3 OTHER_ERN1_HUMAN CAMK 8.5e-36 129.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 5HGIA O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.609 14.643 BLAminus DFGAsp-rot-out -145.05, -173.6 59.23, 77.97 288.76, -15.04 -93.33, 15.89 299.4, 90.09 -56.25, -41.67 in-in in 8.835 Saltbr-in 3.085 HRD-in -70.44, -52.16 82.22, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.82, 158.67 APE9-dihe-na -55.87, 177.33 APE8-dihe-in -86.18, 152.71 APE8-rot-in 291.18 APE67-dihe-inflip 109.66, -27.51 -52.0, 151.26 APE12-dist-in 7.716 APE11-dist-out 6.849 APE10-dist-out 9.218 APE9-dist-in 4.362 None None None XRAY 2.584 0.214 0.247 A 431 395 5 0 0 0 [[571, 832]] 1.0 5hgi OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDFB O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.734 14.864 BLAminus DFGAsp-rot-out -147.47, -177.07 57.93, 76.76 284.41, 4.45 -96.5, 15.93 283.55, 47.82 -59.81, -43.08 in-in in 8.228 Saltbr-in 2.737 HRD-in -73.76, -49.3 76.45, -0.87 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -169.01 APE9-dihe-na 101.44, -83.65 APE8-dihe-in -134.49, 143.31 APE8-rot-in 313.33 APE67-dihe-inflip 129.9, -41.41 -81.7, 159.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.524 APE9-dist-out 7.438 None None None XRAY 2.54 0.209 0.263 B 431 400 3 0 0 2 [[571, 832]] 1.0 6xdf OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3BA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 5.281 15.014 BLAminus DFGAsp-rot-in -143.27, -170.93 56.51, 82.48 187.17, 81.6 -97.69, 18.76 283.82, 27.48 -70.15, -29.01 in-in in 9.017 Saltbr-in 3.226 HRD-in -67.85, -45.67 72.89, 0.99 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -72.27, -21.84 APE9-dihe-na 147.89, -147.39 APE8-dihe-in -108.47, 126.95 APE8-rot-in 297.0 APE67-dihe-inflip 99.73, -10.05 -56.76, 133.68 APE12-dist-in 7.506 APE11-dist-out 7.577 APE10-dist-out 10.04 APE9-dist-in 4.019 None None None XRAY 2.57 0.206 0.246 A 434 398 0 0 0 0 [[571, 832]] 1.0 6w3b OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CA O75460 560 964 977.0 No_ligand No_ligand Active DFGin 6.106 14.236 BLAminus DFGAsp-rot-in -143.3, -169.77 61.92, 75.26 196.73, 30.79 -99.59, 5.17 293.74, 80.96 -57.56, -26.8 in-in in 8.19 Saltbr-in 2.438 HRD-in -73.83, -48.09 71.71, -9.73 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.3, -33.45 APE9-dihe-na -62.43, 169.01 APE8-dihe-in -93.38, 133.53 APE8-rot-in 300.11 APE67-dihe-inflip 106.95, -8.39 -49.76, 124.1 APE12-dist-in 11.245 APE11-dist-in 11.396 APE10-dist-in 5.43 APE9-dist-in 3.449 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 A 434 405 0 0 0 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CB O75460 560 963 977.0 No_ligand No_ligand Active DFGin 6.106 14.899 BLAminus DFGAsp-rot-in -154.48, -168.03 55.85, 78.98 191.84, 22.41 -100.05, 13.54 285.56, 16.26 -60.83, -29.52 in-in in 8.366 Saltbr-in 2.634 HRD-in -75.16, -45.21 69.8, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.23, 157.93 APE9-dihe-na 117.83, 146.57 APE8-dihe-in -81.19, 135.69 APE8-rot-in 308.77 APE67-dihe-inflip 111.32, -6.95 -54.24, 124.62 APE12-dist-in 10.887 APE11-dist-in 10.897 APE10-dist-in 4.957 APE9-dist-in 3.541 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 B 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CC O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.657 15.019 BLAminus DFGAsp-rot-in -147.84, -172.12 60.8, 76.5 191.75, 20.71 -95.31, 10.61 280.4, 53.86 -59.0, -26.79 in-in in 8.706 Saltbr-in 2.721 HRD-in -80.88, -50.26 69.52, 4.83 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.43, 153.53 APE9-dihe-na 125.25, 174.09 APE8-dihe-in -105.72, 131.11 APE8-rot-in 300.67 APE67-dihe-inflip 110.66, -4.8 -51.94, 122.81 APE12-dist-in 11.239 APE11-dist-in 11.12 APE10-dist-in 5.218 APE9-dist-in 3.675 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 C 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CD O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.932 15.058 BLAminus DFGAsp-rot-in -157.54, -163.82 60.31, 71.97 215.83, 27.37 -98.14, 3.34 281.98, 17.28 -56.04, -29.73 in-in in 8.642 Saltbr-in 2.715 HRD-in -75.91, -46.58 71.49, -6.58 in-in-in SNCiii in-in ActLoopNT-in 2.71 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.66, -18.6 APE9-dihe-na -64.06, 167.42 APE8-dihe-in -92.49, 134.25 APE8-rot-in 304.43 APE67-dihe-inflip 103.66, -4.02 -51.74, 125.98 APE12-dist-in 11.302 APE11-dist-in 11.218 APE10-dist-in 5.258 APE9-dist-in 3.482 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 D 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus DFGAsp-rot-in -149.66, -173.45 57.49, 66.53 201.33, -9.38 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus DFGAsp-rot-in -140.88, -173.22 59.3, 72.64 207.2, -16.91 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWA O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.753 15.848 BLAminus DFGAsp-rot-in -137.11, -164.14 55.29, 61.49 216.41, -10.57 -82.92, 7.86 279.34, 27.53 -61.24, -35.15 in-in in 9.281 Saltbr-in 3.217 HRD-in -66.48, -56.29 77.33, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.9, 139.91 APE9-dihe-na 137.0, 174.42 APE8-dihe-in -105.74, 137.36 APE8-rot-in 313.93 APE67-dihe-inflip 116.47, -18.45 -55.17, 118.89 APE12-dist-in 10.655 APE11-dist-in 11.273 APE10-dist-in 5.237 APE9-dist-in 3.631 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 A 434 403 0 0 0 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWB O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.659 15.595 BLAminus DFGAsp-rot-in -145.27, -164.83 46.92, 70.18 188.19, 78.23 -87.21, 11.29 280.69, 69.55 -62.43, -36.43 in-in in 9.514 Saltbr-in 2.916 HRD-in -81.2, -46.9 74.25, -11.86 in-in-out SNCiio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -59.45, 144.76 APE9-dihe-na 126.14, -167.15 APE8-dihe-in -135.75, 140.85 APE8-rot-out 210.8 APE67-dihe-inflip 99.64, -22.14 -57.98, 140.11 APE12-dist-in 10.802 APE11-dist-in 11.2 APE10-dist-in 5.274 APE9-dist-in 3.54 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 B 434 403 0 0 0 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWC O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.635 15.559 BLAminus DFGAsp-rot-in -132.52, 179.7 73.16, 53.18 215.43, 48.35 -77.31, 13.24 285.48, 55.31 -73.1, -19.29 in-in in 9.039 Saltbr-in 3.019 HRD-in -82.58, -51.91 71.45, 18.84 in-in-in SNCiii in-in ActLoopNT-in 2.63 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.81, 130.02 APE9-dihe-na 148.27, 178.17 APE8-dihe-in -119.07, 134.7 APE8-rot-in 323.09 APE67-dihe-inflip 99.28, -15.5 -52.59, 133.44 APE12-dist-in 10.773 APE11-dist-in 11.223 APE10-dist-in 5.348 APE9-dist-in 3.665 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 C 434 403 0 0 0 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWD O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.877 15.941 BLAminus DFGAsp-rot-in -144.08, -162.9 48.88, 78.62 175.05, -52.73 -99.04, 18.45 261.61, 69.28 -69.53, -42.63 in-out in 9.474 Saltbr-out 3.697 HRD-in -82.34, -51.42 71.84, 19.12 out-in-out SNCoio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -60.38, 141.0 APE9-dihe-na 147.72, -174.34 APE8-dihe-in -119.1, 140.61 APE8-rot-out 31.47 APE67-dihe-inflip 82.22, -18.82 -56.96, 151.1 APE12-dist-in 10.965 APE11-dist-in 11.521 APE10-dist-in 5.448 APE9-dist-in 3.936 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 D 434 303 2 0 0 0 [[571, 832]] 1.0 9gow OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.486 BLAminus DFGAsp-rot-in -136.61, -178.37 67.07, 78.89 204.21, -11.93 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.204 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.729 APE9-dist-in 3.977 None None None XRAY 2.08 0.192 0.217 A 434 398 4 0 0 4 [[571, 832]] 1.0 6w3k OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3EB O75460 563 963 977.0 SJV:1001 Type1.5_Back Inactive DFGin 5.795 15.517 BLAminus DFGAsp-rot-in -141.88, 176.99 63.2, 84.04 191.54, 20.4 -105.56, 28.54 300.08, 169.13 -67.07, -42.47 out-out out 10.107 Saltbr-out 5.707 HRD-out -80.93, 139.0 -122.23, -35.4 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na -74.91, 153.53 APE8-dihe-out 63.33, 175.78 APE8-rot-out 67.1 APE67-dihe-inflip 108.9, -22.83 -150.99, 138.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.146 APE9-dist-out 6.983 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 B 431 389 12 0 0 4 [[571, 832]] 1.0 6w3e OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDFA O75460 560 966 977.0 N94:1002 Type1.5_Back Inactive DFGin 6.383 15.199 BLAminus DFGAsp-rot-in -130.29, -176.4 60.9, 76.83 197.37, -0.9 -90.68, 29.29 294.67, 76.62 -70.73, -33.39 out-out out 10.156 Saltbr-out 5.093 HRD-in -82.04, -48.49 78.58, -9.6 out-in-out SNCoio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.17, -32.0 APE9-dihe-na 161.12, -145.76 APE8-dihe-in -111.23, 117.63 APE8-rot-in 300.24 APE67-dihe-inflip 110.41, -26.97 -49.33, 126.92 APE12-dist-in 7.63 APE11-dist-out 6.918 APE10-dist-out 9.798 APE9-dist-in 3.86 None None None XRAY 2.54 0.209 0.263 A 431 402 5 0 0 0 [[571, 832]] 1.0 6xdf OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 7BMKA O75460 561 966 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.305 15.604 BLAminus DFGAsp-rot-in -134.78, 175.72 71.56, 88.08 201.19, -25.98 -95.42, 16.11 280.14, 64.53 -63.54, -33.93 out-out out 10.62 Saltbr-out 5.429 HRD-in -79.03, -50.32 75.82, -1.9 out-in-out SNCoio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -71.86, -22.99 APE9-dihe-na 146.38, -151.63 APE8-dihe-in -103.7, 128.54 APE8-rot-in 300.23 APE67-dihe-inflip 91.08, -11.6 -49.87, 131.36 APE12-dist-in 7.482 APE11-dist-out 7.01 APE10-dist-out 9.895 APE9-dist-in 3.716 None None None XRAY 1.85 0.192 0.235 A 434 406 0 0 0 0 [[571, 832]] 1.0 7bmk OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 7BMKB O75460 562 963 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.47 15.557 BLAminus DFGAsp-rot-in -136.75, 176.32 69.57, 85.31 201.68, -26.76 -94.6, 15.21 280.65, 62.8 -61.14, -35.65 out-out out 10.425 Saltbr-out 5.295 HRD-in -76.97, -51.76 73.84, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioio APE10-dihe-na -80.44, 159.09 APE9-dihe-na -62.97, -36.0 APE8-dihe-in -102.05, 125.52 APE8-rot-in 305.35 APE67-dihe-inflip 117.81, -24.89 -71.98, 170.65 APE12-dist-in 10.017 APE11-dist-out 6.417 APE10-dist-in 7.066 APE9-dist-out 8.735 None None None XRAY 1.85 0.192 0.235 B 434 392 10 0 0 0 [[571, 832]] 1.0 7bmk OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6URCA O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.171 14.431 BLAminus DFGAsp-rot-in -137.78, -167.93 65.57, 72.79 216.46, -14.78 -93.53, 16.27 296.4, 97.38 -65.24, -15.16 out-out out 10.078 Saltbr-out 5.427 HRD-in -79.31, -54.62 74.23, 3.96 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.3, -9.99 APE9-dihe-na 149.54, -144.19 APE8-dihe-in -113.92, 127.41 APE8-rot-in 303.4 APE67-dihe-inflip 100.0, -7.56 -46.92, 125.76 APE12-dist-in 10.921 APE11-dist-out 7.261 APE10-dist-out 9.666 APE9-dist-in 3.801 None None None XRAY 2.2 0.223 0.274 A 434 400 0 0 0 0 [[571, 832]] 1.0 6urc OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6URCB O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.051 14.225 BLAminus DFGAsp-rot-in -133.22, -173.47 69.03, 75.97 207.3, -25.89 -95.56, 16.52 300.55, 96.62 -60.7, -19.84 out-out out 10.062 Saltbr-out 5.58 HRD-in -76.52, -51.32 73.26, 7.62 out-in-out SNCoio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -86.29, -17.31 APE9-dihe-na 144.52, -148.41 APE8-dihe-in -105.98, 124.4 APE8-rot-in 298.12 APE67-dihe-inflip 103.6, -12.44 -49.39, 126.46 APE12-dist-in 10.817 APE11-dist-out 7.084 APE10-dist-out 9.909 APE9-dist-in 3.837 None None None XRAY 2.2 0.223 0.274 B 434 398 0 0 0 0 [[571, 832]] 1.0 6urc OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDB O75460 560 963 977.0 N97:1001 Type1.5_Back Inactive DFGin 7.109 14.526 BLAminus DFGAsp-rot-in -139.89, -179.2 70.17, 73.7 194.07, 16.37 -98.79, 17.74 298.51, 86.41 -64.67, -28.57 in-out in 9.962 Saltbr-out 5.494 HRD-in -74.08, -50.98 72.16, 2.0 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.87, 142.87 APE9-dihe-na 140.33, 179.07 APE8-dihe-in -119.71, 134.07 APE8-rot-in 305.81 APE67-dihe-inflip 102.26, -11.35 -53.88, 126.31 APE12-dist-in 10.974 APE11-dist-in 10.707 APE10-dist-in 4.783 APE9-dist-in 3.481 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 B 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4U6RA O75460 561 963 977.0 3E4:1001 Type1.5_Back Inactive DFGin 7.047 14.409 BLAminus DFGAsp-rot-in -137.98, -174.58 66.91, 71.23 213.38, 2.11 -95.79, 12.94 302.54, 101.22 -59.26, -23.05 out-out out 10.674 Saltbr-out 5.974 HRD-in -69.95, -43.6 74.35, -6.96 out-in-out SNCoio in-out ActLoopNT-in 2.993 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.62, 70.84 APE9-dihe-na 123.49, -154.22 APE8-dihe-in -117.41, 132.07 APE8-rot-in 301.36 APE67-dihe-inflip 102.11, -11.56 -49.68, 126.85 APE12-dist-in 11.011 APE11-dist-in 10.273 APE10-dist-out 8.43 APE9-dist-in 3.436 None None None XRAY 2.5 0.204 0.246 A 455 403 0 0 0 0 [[571, 832]] 1.0 4u6r OTHER_ERN1_HUMAN CAMK 4e-35 127.7 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDBA O75460 561 964 977.0 N8S:1001 Type1.5_Back Inactive DFGin 7.133 14.329 BLAminus DFGAsp-rot-in -132.32, -176.36 63.12, 79.47 189.86, -4.5 -100.65, 32.62 307.21, 90.79 -67.25, -28.96 out-out out 10.475 Saltbr-out 4.795 HRD-in -83.13, -48.83 76.19, 2.79 out-in-out SNCoio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -66.73, -30.45 APE9-dihe-na 149.19, -146.33 APE8-dihe-in -109.5, 126.62 APE8-rot-in 302.1 APE67-dihe-inflip 92.9, -11.46 -58.42, 139.25 APE12-dist-in 7.086 APE11-dist-out 6.84 APE10-dist-out 9.792 APE9-dist-in 3.979 None None None XRAY 2.45 0.195 0.227 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdb OTHER_ERN1_HUMAN CAMK 3.2e-34 124.7 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.559 15.899 BLAminus DFGAsp-rot-out -140.85, 172.03 60.0, 89.13 289.15, -33.3 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.584 Saltbr-out 7.056 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431 366 31 0 0 21 [[571, 832]] 1.0 6w3e OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.489 15.205 BLAminus DFGAsp-rot-out -139.2, -157.42 53.89, 65.22 274.02, 87.33 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.188 Saltbr-out 12.042 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.114 APE10-dist-in 7.347 APE9-dist-out 9.016 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.499 14.81 BLAminus DFGAsp-rot-in -137.56, -175.69 71.07, 82.79 202.33, -9.91 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.069 Saltbr-out 11.269 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.721 APE11-dist-out 7.141 APE10-dist-out 10.097 APE9-dist-in 3.899 None None None XRAY 2.43 0.184 0.251 A 448 403 0 0 0 0 [[571, 832]] 1.0 8uvl OTHER_ERN1_HUMAN CAMK 3.5e-34 124.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.106 13.454 BLBplus DFGAsp-rot-out -141.52, 169.79 75.76, 4.13 294.43, 24.59 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.885 Saltbr-out 13.41 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.406 APE10-dist-out 8.161 APE9-dist-in 3.423 None None None XRAY 3.102 0.234 0.273 A 405 383 18 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.204 13.179 BLBplus DFGAsp-rot-out -141.12, 169.65 69.57, 15.58 293.67, 24.1 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.88 Saltbr-out 13.118 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.672 APE10-dist-in 7.568 APE9-dist-in 3.528 None None None XRAY 3.102 0.234 0.273 B 405 385 15 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.292 13.556 BLBplus DFGAsp-rot-out -142.06, 170.34 76.33, 5.28 296.09, 25.39 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.194 Saltbr-out 13.253 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.41 APE10-dist-in 7.784 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405 379 21 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.34 13.709 BLBplus DFGAsp-rot-out -135.51, 176.11 64.76, 22.4 294.34, -2.15 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.088 Saltbr-out 13.069 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.558 APE10-dist-out 9.123 APE9-dist-in 3.196 None None None XRAY 2.7 0.238 0.294 A 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.483 13.646 BLBplus DFGAsp-rot-out -139.9, 176.5 76.83, 14.87 282.35, -2.41 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.936 Saltbr-out 12.658 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.701 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.213 APE9-dist-in 3.477 None None None XRAY 2.7 0.238 0.294 B 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.544 13.173 BLBplus DFGAsp-rot-out -149.53, -176.42 65.18, 18.98 297.03, -0.74 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.142 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.838 APE11-dist-in 13.243 APE10-dist-out 9.353 APE9-dist-in 3.507 None None None XRAY 2.7 0.238 0.294 C 432 390 14 0 0 11 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.409 13.263 BLBplus DFGAsp-rot-out -138.88, 177.03 72.28, 10.83 287.64, -11.27 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.018 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.113 APE9-dist-in 4.038 None None None XRAY 2.7 0.238 0.294 D 432 387 16 0 0 14 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9N88A O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.495 14.396 BLBplus DFGAsp-rot-out -125.12, 173.56 61.62, 32.01 306.9, -52.71 -93.6, 167.16 52.37, 88.56 65.58, 27.08 in-in in 8.405 Saltbr-in 2.935 HRD-in -63.01, -46.54 69.36, -1.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.47 APE9-dihe-na 82.39, -50.55 APE8-dihe-in -47.73, 127.95 APE8-rot-in 291.31 APE67-dihe-inflip 89.37, 13.1 -79.77, 123.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.432 APE9-dist-out 7.977 None None None EM 2.6 999.0 999.0 A 402 379 23 0 0 16 [[571, 832]] 1.0 9n88 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9N88E O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.496 14.396 BLBplus DFGAsp-rot-out -125.13, 173.55 61.65, 32.03 306.85, -52.71 -93.6, 167.11 52.36, 88.6 65.62, 27.08 in-in in 8.405 Saltbr-in 2.936 HRD-in -63.0, -46.58 69.41, -1.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.45 APE9-dihe-na 82.42, -50.53 APE8-dihe-in -47.73, 127.97 APE8-rot-in 291.31 APE67-dihe-inflip 89.32, 13.1 -79.8, 123.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.433 APE9-dist-out 7.977 None None None EM 2.6 999.0 999.0 E 402 379 23 0 0 16 [[571, 832]] 1.0 9n88 OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W39A O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.589 14.569 BLBplus DFGAsp-rot-in -139.66, 174.98 64.22, 28.56 227.24, 9.69 -90.96, 160.06 48.25, 86.99 74.2, -3.07 in-in in 8.854 Saltbr-in 2.868 HRD-in -66.64, -55.32 82.3, -19.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 195.33 APE67-dihe-out 108.3, -8.16 -110.65, -131.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 A 431 374 24 0 0 19 [[571, 832]] 1.0 6w39 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W39B O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.61 14.538 BLBplus DFGAsp-rot-in -144.1, 177.6 64.91, 27.62 224.26, 9.89 -88.82, 154.64 46.85, 89.19 64.91, 16.36 in-in in 8.582 Saltbr-in 3.517 HRD-in -72.2, -52.15 80.89, -14.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.25 APE8-rot-out 67.26 APE67-dihe-out 104.99, -2.33 -121.34, -117.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 B 431 374 25 0 0 19 [[571, 832]] 1.0 6w39 OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3AA O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.687 14.75 BLBplus DFGAsp-rot-in -159.03, 176.32 57.32, 40.69 198.07, 32.79 -104.35, 145.33 50.26, 89.45 73.99, 38.41 in-in in 8.719 Saltbr-in 2.941 HRD-in -70.5, -44.05 68.58, -4.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.79 APE8-dihe-out -141.14, -179.39 APE8-rot-out 65.3 APE67-dihe-out 122.02, -15.91 -119.08, -128.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.577 None None None XRAY 2.606 0.249 0.29 A 434 363 32 0 0 18 [[571, 832]] 1.0 6w3a OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3AB O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.444 14.584 BLBplus DFGAsp-rot-in -150.2, 175.33 54.85, 42.0 202.33, 39.76 -103.74, 137.1 52.82, 87.58 88.2, 19.62 in-out in 8.543 Saltbr-out 3.645 HRD-in -69.7, -38.0 68.52, -8.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.7 APE8-dihe-out -126.01, -171.29 APE8-rot-out 66.29 APE67-dihe-out 116.07, -16.83 -111.97, -139.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.654 None None None XRAY 2.606 0.249 0.29 B 434 371 25 0 0 17 [[571, 832]] 1.0 6w3a OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.996 14.533 None DFGAsp-rot-out -140.81, 175.34 43.48, 101.03 332.01, -33.09 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.947 Saltbr-in 2.84 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.834 None None None XRAY 2.6 0.204 0.226 A 416 366 26 0 0 19 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.91 14.386 None DFGAsp-rot-out -141.89, 174.99 45.35, 92.04 295.13, -84.28 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.832 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.835 None None None XRAY 2.6 0.204 0.226 B 416 377 24 0 0 18 [[571, 832]] 1.0 4z7g OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.393 14.977 None DFGAsp-rot-in -138.87, -45.43 -76.98, 88.77 226.44, -27.39 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.851 Saltbr-in 2.809 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.613 APE9-dist-in 4.646 None None None XRAY 2.9 0.202 0.225 A 416 385 10 0 0 5 [[571, 832]] 1.0 4z7h OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.93 7.257 None DFGAsp-rot-in -145.42, 154.32 -79.25, -25.27 169.85, 66.54 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.782 None None None XRAY 2.463 0.238 0.283 A 405 381 22 0 0 17 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.04 7.266 None DFGAsp-rot-in -150.4, 164.44 -74.79, -40.79 159.24, 51.75 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.359 Saltbr-out 7.616 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405 375 24 0 0 19 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.11 None DFGAsp-rot-out -135.14, 175.91 -93.49, -10.88 55.66, -53.54 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.749 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405 378 25 0 0 18 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6HX1A O75460 562 964 977.0 GXK:1001 Type1 Inactive None 999.0 9.031 None DFGAsp-rot-out -117.25, 153.54 -78.62, -34.04 54.08, -25.55 -91.96, 133.47 286.33, 72.45 -93.93, 146.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.4, -55.14 79.73, -2.12 none-out-out SNCnoo out-out ActLoopNT-out 22.478 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -51.71, 130.91 APE9-dihe-na 103.58, -28.73 APE8-dihe-out -114.51, 37.72 APE8-rot-out 76.32 APE67-dihe-in -78.77, 3.79 -81.24, -41.88 APE12-dist-in 12.341 APE11-dist-in 9.378 APE10-dist-out 11.323 APE9-dist-out 15.695 None None None XRAY 2.14 0.219 0.268 A 403 387 16 0 0 2 [[571, 832]] 1.0 6hx1 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6HV0A O75460 562 963 977.0 GUK:1001 Type1 Inactive None 999.0 9.182 None DFGAsp-rot-out -133.1, 153.75 -66.3, -48.4 338.01, -79.32 -89.37, 135.79 292.63, 70.49 -93.67, 142.5 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.37, -40.56 70.66, -13.49 none-out-out SNCnoo out-out ActLoopNT-out 22.512 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -88.59, 128.96 APE9-dihe-na -116.2, 97.18 APE8-dihe-out -118.13, -15.29 APE8-rot-in 276.8 APE67-dihe-inflip 101.83, -26.03 -49.76, 144.64 APE12-dist-in 12.836 APE11-dist-in 10.086 APE10-dist-out 11.662 APE9-dist-out 15.745 None None None XRAY 2.73 0.217 0.269 A 416 377 23 0 0 0 [[571, 832]] 1.0 6hv0 OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN2 ERN2_HUMAN AF-Q76MJ5-K1A Q76MJ5 510 789 926.0 No_ligand No_ligand Active DFGin 5.368 14.29 BLAminus DFGAsp-rot-in -135.16, 175.78 56.74, 78.02 199.18, 16.08 -85.53, 10.57 279.65, 57.28 -61.02, -29.35 in-in in 8.696 Saltbr-in 2.646 HRD-in -73.42, -46.06 62.52, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.28, 151.27 APE9-dihe-na 120.63, 170.37 APE8-dihe-in -93.63, 136.3 APE8-rot-in 303.23 APE67-dihe-inflip 84.69, -7.7 -49.91, 132.98 APE12-dist-in 10.985 APE11-dist-in 11.126 APE10-dist-in 5.34 APE9-dist-in 3.31 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[520, 781]] 1.0 AF-Q76MJ5-K1 OTHER_ERN2_HUMAN CAMK 1.9e-33 121.8 4 256 253 659 660 661 663 665 548 561 565 634 636 635 637 705 690 685 684 683 682 681 680 679 592 Serine/threonine-protein kinase/endoribonuclease IRE2
OTHER ERN2 ERN2_HUMAN AF-Q76MJ5-K3A Q76MJ5 510 789 926.0 No_ligand No_ligand Active DFGin 5.202 14.149 BLAminus DFGAsp-rot-in -133.23, 178.12 57.36, 72.26 201.92, 14.29 -80.59, 4.94 281.49, 67.16 -60.5, -31.63 in-in in 8.569 Saltbr-in 2.641 HRD-in -72.7, -48.8 67.08, -3.82 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.36, 145.49 APE9-dihe-na 122.75, -170.94 APE8-dihe-in -109.07, 136.09 APE8-rot-in 299.3 APE67-dihe-inflip 80.11, -5.41 -51.08, 134.07 APE12-dist-in 10.76 APE11-dist-in 11.181 APE10-dist-in 5.554 APE9-dist-in 3.145 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[520, 781]] 1.0 AF-Q76MJ5-K3 OTHER_ERN2_HUMAN CAMK 1.9e-33 121.8 4 256 253 659 660 661 663 665 548 561 565 634 636 635 637 705 690 685 684 683 682 681 680 679 592 Serine/threonine-protein kinase/endoribonuclease IRE2
OTHER GAK GAK_HUMAN 4O38A O14976 25 334 1311.0 No_ligand No_ligand Inactive DFGin 5.659 13.735 ABAminus DFGAsp-rot-out -138.06, -2.27 -113.83, 85.58 50.35, -28.87 -104.61, 19.83 303.3, 120.26 -68.6, -17.05 in-in in 8.916 Saltbr-in 2.609 HRD-in -79.1, -51.28 74.73, -0.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE89,MSE137,MSE162,MSE225,MSE295 XRAY 2.097 0.166 0.195 A 338 267 43 0 0 28 [[40, 313]] 1.0 4o38 OTHER_GAK_HUMAN CAMK 5.4e-44 156.8 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4O38B O14976 26 337 1311.0 No_ligand No_ligand Inactive DFGin 5.602 13.735 ABAminus DFGAsp-rot-out -142.92, -2.71 -112.18, 83.29 52.57, -29.29 -104.79, 22.19 305.95, 119.3 -69.31, -19.55 in-in in 8.972 Saltbr-in 2.62 HRD-in -73.83, -51.42 73.13, -3.06 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE89,MSE137,MSE162,MSE225,MSE295 XRAY 2.097 0.166 0.195 B 338 276 36 0 0 24 [[40, 313]] 1.0 4o38 OTHER_GAK_HUMAN CAMK 5.4e-44 156.8 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZA O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.183 14.302 ABAminus DFGAsp-rot-in -120.31, -65.73 -84.03, 133.07 201.13, -48.13 -132.73, 38.63 297.55, 94.83 -80.73, -23.71 in-in in 9.33 Saltbr-in 2.653 HRD-in -76.12, -47.1 64.19, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.58, 12.1 APE9-dihe-na -127.21, 155.97 APE8-dihe-in -88.88, 126.92 APE8-rot-in 301.28 APE67-dihe-in -75.82, -11.44 -39.58, -53.85 APE12-dist-in 11.675 APE11-dist-in 8.741 APE10-dist-in 4.165 APE9-dist-in 4.146 None None None XRAY 2.804 0.235 0.288 A 313 311 0 0 0 0 [[40, 313]] 1.0 5y7z OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZB O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.185 14.3 ABAminus DFGAsp-rot-in -126.63, -59.42 -85.24, 119.57 194.9, -84.95 -121.34, 32.24 292.7, 91.36 -76.51, -21.75 in-in in 8.998 Saltbr-in 3.336 HRD-in -76.77, -44.95 63.95, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.15, 9.34 APE9-dihe-na -125.96, 148.71 APE8-dihe-in -79.22, 127.62 APE8-rot-in 300.16 APE67-dihe-in -76.26, -13.67 -39.68, -52.24 APE12-dist-in 11.771 APE11-dist-in 8.765 APE10-dist-in 4.231 APE9-dist-in 4.002 None None None XRAY 2.804 0.235 0.288 B 313 311 0 0 0 0 [[40, 313]] 1.0 5y7z OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.754 14.141 ABAminus DFGAsp-rot-in -112.53, -37.31 -102.07, 134.52 194.59, 87.18 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.993 Saltbr-out 4.057 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.779 APE11-dist-in 8.573 APE10-dist-in 4.33 APE9-dist-in 4.07 None None None XRAY 2.55 0.18 0.228 A 340 310 0 0 0 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.769 14.233 ABAminus DFGAsp-rot-in -105.07, -37.59 -101.51, 133.86 195.58, 86.45 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.065 Saltbr-out 4.056 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.928 APE11-dist-in 8.658 APE10-dist-in 4.358 APE9-dist-in 4.086 None None None XRAY 2.55 0.18 0.228 B 340 308 0 0 0 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.815 13.68 ABAminus DFGAsp-rot-out -134.62, -10.32 -105.18, 88.43 56.13, -28.88 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.093 Saltbr-in 2.855 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.838 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340 266 41 0 0 27 [[40, 313]] 1.0 4c59 OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y80A O14976 25 332 1311.0 IRE:60401,IRE:60402 Type1,Allosteric Inactive DFGin 6.283 14.516 ABAminus DFGAsp-rot-in -119.77, -54.31 -90.82, 110.26 200.33, -45.28 -111.11, 18.56 296.38, 94.44 -67.28, -25.31 in-in in 8.858 Saltbr-in 3.281 HRD-in -69.89, -47.62 68.73, -10.18 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.53, 10.66 APE9-dihe-na -135.16, 171.64 APE8-dihe-in -123.07, 133.96 APE8-rot-in 293.66 APE67-dihe-in -69.42, -14.72 -40.65, -51.06 APE12-dist-out 14.946 APE11-dist-in 13.254 APE10-dist-out 8.056 APE9-dist-out 7.473 None None None XRAY 2.5 0.232 0.282 A 313 305 3 0 0 0 [[40, 313]] 1.0 5y80 OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C58A O14976 27 333 1311.0 824:1336 Type1.5_Back Inactive DFGin 5.777 13.798 ABAminus DFGAsp-rot-out -132.89, -19.04 -95.75, 85.27 49.95, -26.27 -100.86, 19.52 307.21, 107.98 -74.39, -16.9 in-in in 8.74 Saltbr-in 2.956 HRD-in -74.87, -50.0 69.14, -1.84 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.16 0.182 0.242 A 340 267 40 0 0 27 [[40, 313]] 1.0 4c58 OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN AF-O14976-K1A O14976 32 323 1311.0 No_ligand No_ligand Active DFGin 5.84 13.848 BLAminus DFGAsp-rot-in -133.45, 179.28 63.44, 74.32 200.17, 15.75 -88.75, 11.98 300.95, 94.46 -62.76, -26.27 in-in in 9.142 Saltbr-in 2.717 HRD-in -75.98, -39.23 66.88, -25.57 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.79, 15.15 APE9-dihe-na -139.7, 139.56 APE8-dihe-in -75.05, 126.47 APE8-rot-in 295.45 APE67-dihe-in -68.97, -25.92 -48.51, -43.87 APE12-dist-in 11.773 APE11-dist-in 8.649 APE10-dist-in 4.333 APE9-dist-in 3.787 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[40, 313]] 1.0 AF-O14976-K1 OTHER_GAK_HUMAN CAMK 3.2e-44 157.5 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN AF-O14976-K3A O14976 32 323 1311.0 No_ligand No_ligand Active DFGin 5.703 13.574 BLAminus DFGAsp-rot-in -134.69, -175.6 59.61, 75.73 198.95, 23.71 -91.2, 13.21 303.62, 95.59 -60.85, -31.12 in-in in 8.973 Saltbr-in 2.659 HRD-in -75.64, -41.0 67.38, -33.91 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.15, 16.85 APE9-dihe-na -144.17, 136.49 APE8-dihe-in -72.61, 126.92 APE8-rot-in 297.17 APE67-dihe-in -69.9, -24.24 -50.23, -46.59 APE12-dist-in 11.897 APE11-dist-in 8.52 APE10-dist-in 4.415 APE9-dist-in 4.26 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[40, 313]] 1.0 AF-O14976-K3 OTHER_GAK_HUMAN CAMK 3.2e-44 157.5 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DA O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.562 13.518 BLAminus DFGAsp-rot-in -138.4, -164.21 74.62, 66.04 199.54, -60.61 -93.04, 16.88 304.79, 110.01 -68.29, -18.06 in-in in 8.973 Saltbr-in 2.822 HRD-in -78.84, -52.81 74.15, 0.63 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 A 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DB O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.558 13.438 BLAminus DFGAsp-rot-in -140.66, -164.98 74.22, 67.3 200.82, -62.27 -94.1, 19.71 305.39, 110.44 -72.07, -18.1 in-in in 8.927 Saltbr-in 2.81 HRD-in -76.85, -53.12 74.48, -1.34 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 B 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 3DLZA Q8TF76 470 798 798.0 AMP:902 ATPlike Active DFGin 5.254 12.469 BLAminus DFGAsp-rot-in -120.14, 174.05 73.32, 91.07 190.81, 8.01 -105.92, 29.14 315.79, 130.04 -57.27, -36.15 in-in in 9.264 Saltbr-in 2.695 HRD-na-N -71.0, -49.07 68.99, 3.03 in-in-na SNCiia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -122.28, 17.39 APE9-dihe-na -67.57, 157.85 APE8-dihe-na -149.51, 177.99 APE8-rot-na 58.52 APE67-dihe-na -159.03, 144.74 95.06, -6.22 APE12-dist-na 9.493 APE11-dist-na 13.466 APE10-dist-na 17.05 APE9-dist-na 12.819 None None None XRAY 1.85 0.167 0.216 A 357 329 0 0 0 0 [[484, 797]] 1.0 3dlz OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN AF-Q8TF76-K1A Q8TF76 476 798 798.0 No_ligand No_ligand Active DFGin 4.997 12.374 BLAminus DFGAsp-rot-in -138.62, 174.68 57.97, 91.28 208.87, -40.4 -100.94, 21.93 314.77, 120.9 -55.94, -45.23 in-in in 9.18 Saltbr-in 2.711 HRD-na-N -75.36, -43.16 61.41, 5.31 in-in-na SNCiia in-na ActLoopNT-in 2.839 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.17, -12.71 APE9-dihe-na -54.03, 150.53 APE8-dihe-na -147.69, 169.0 APE8-rot-na 193.38 APE67-dihe-na -135.11, 149.27 98.64, -16.5 APE12-dist-na 9.305 APE11-dist-na 13.309 APE10-dist-na 16.98 APE9-dist-na 12.992 None None None AF2 -1.0 1.0 1.0 A 323 323 0 0 0 0 [[484, 797]] 1.0 AF-Q8TF76-K1 OTHER_HASPIN_HUMAN HASP 9.5e-227 757.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN AF-Q8TF76-K3A Q8TF76 476 798 798.0 No_ligand No_ligand Active DFGin 4.951 12.431 BLAminus DFGAsp-rot-in -133.71, 176.01 54.85, 96.46 208.95, -47.1 -104.75, 21.31 315.54, 124.63 -56.24, -41.59 in-in in 9.299 Saltbr-in 2.719 HRD-na-N -75.19, -42.52 61.0, 1.07 in-in-na SNCiia in-na ActLoopNT-in 2.885 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.31, -18.43 APE9-dihe-na -56.71, 155.17 APE8-dihe-na -141.59, -175.7 APE8-rot-na 73.98 APE67-dihe-na -125.54, 149.77 84.64, -25.13 APE12-dist-na 9.207 APE11-dist-na 13.228 APE10-dist-na 16.926 APE9-dist-na 13.133 None None None AF2 -1.0 1.0 1.0 A 323 323 0 0 0 0 [[484, 797]] 1.0 AF-Q8TF76-K3 OTHER_HASPIN_HUMAN HASP 9.5e-227 757.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 2WB8A Q8TF76 447 798 798.0 No_ligand No_ligand Active DFGin 5.22 12.191 BLAminus DFGAsp-rot-in -120.69, 176.87 68.15, 91.75 182.81, 7.12 -104.26, 25.9 315.71, 126.12 -56.01, -32.87 in-in in 9.095 Saltbr-in 2.281 HRD-na-N -69.54, -53.11 72.35, 6.09 in-in-na SNCiia in-na ActLoopNT-in 2.857 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -129.5, 34.17 APE9-dihe-na -83.79, 164.98 APE8-dihe-na -149.79, 174.65 APE8-rot-na 31.25 APE67-dihe-na -168.04, 143.08 80.64, 14.62 APE12-dist-na 9.206 APE11-dist-na 12.948 APE10-dist-na 16.727 APE9-dist-na 12.724 None None None XRAY 2.15 0.23 0.267 A 352 351 1 0 0 0 [[484, 797]] 1.0 2wb8 OTHER_HASPIN_HUMAN HASP 1.3e-226 756.7 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 5HTBA Q8TF76 471 798 798.0 No_ligand No_ligand Active DFGin 4.886 12.713 BLAminus DFGAsp-rot-in -127.82, 172.38 75.8, 95.98 197.2, -43.07 -111.9, 24.65 313.35, 119.25 -57.64, -36.0 in-in in 9.095 Saltbr-in 2.722 HRD-na-N -72.45, -46.3 70.77, -0.27 in-in-na SNCiia in-na ActLoopNT-in 2.859 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.52, 17.28 APE9-dihe-na -71.3, 162.17 APE8-dihe-na -148.2, 163.96 APE8-rot-na 208.0 APE67-dihe-na -159.11, 139.67 91.05, 1.41 APE12-dist-na 9.417 APE11-dist-na 13.298 APE10-dist-na 16.873 APE9-dist-na 12.933 None None None XRAY 1.7 0.163 0.181 A 357 328 0 0 0 0 [[484, 797]] 1.0 5htb OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 5HTCA Q8TF76 471 798 798.0 No_ligand No_ligand Active DFGin 5.008 12.77 BLAminus DFGAsp-rot-in -124.68, 170.56 74.88, 95.44 186.86, 13.38 -108.39, 22.99 316.66, 123.43 -55.96, -37.72 in-in in 9.222 Saltbr-in 2.671 HRD-na-N -71.81, -49.47 73.17, 0.66 in-in-na SNCiia in-na ActLoopNT-in 2.875 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.86, 18.07 APE9-dihe-na -74.58, 161.83 APE8-dihe-na -153.14, 168.43 APE8-rot-na 79.76 APE67-dihe-na -159.07, 137.97 97.79, -1.9 APE12-dist-na 9.518 APE11-dist-na 13.376 APE10-dist-na 16.983 APE9-dist-na 12.965 None None None XRAY 1.5 0.151 0.171 A 357 328 0 0 0 0 [[484, 797]] 1.0 5htc OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2SK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 6.064 12.671 BLAminus DFGAsp-rot-in -142.15, 178.43 60.64, 69.74 203.46, 17.96 -94.32, 35.13 330.57, 110.31 -71.54, -20.41 out-out out 10.509 Saltbr-out 8.91 HRD-na-N -103.48, -39.3 72.01, 16.12 out-in-na SNCoia in-na ActLoopNT-in 2.662 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.15, 4.32 APE9-dihe-na -71.11, 161.22 APE8-dihe-na -159.47, 164.4 APE8-rot-na 76.0 APE67-dihe-na -157.32, 146.25 103.48, -10.17 APE12-dist-na 10.384 APE11-dist-na 14.356 APE10-dist-na 17.698 APE9-dist-na 13.728 None None None EM 3.01 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2s OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2UK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 5.926 12.627 BLAminus DFGAsp-rot-in -136.69, -178.38 59.48, 67.33 187.97, 1.77 -92.11, 31.61 333.66, 107.16 -67.05, -16.22 out-out out 10.457 Saltbr-out 8.398 HRD-na-N -100.22, -40.69 78.07, 2.57 out-in-na SNCoia in-na ActLoopNT-in 2.756 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -100.28, 9.24 APE9-dihe-na -71.6, 162.97 APE8-dihe-na -157.23, 160.72 APE8-rot-na 81.21 APE67-dihe-na -151.55, 148.6 98.32, -9.69 APE12-dist-na 10.577 APE11-dist-na 14.628 APE10-dist-na 17.968 APE9-dist-na 13.833 None None None EM 3.64 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2u OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G39A Q8TF76 471 798 798.0 5ID:802 Type1 Active DFGin 5.021 12.32 BLAminus DFGAsp-rot-in -127.21, 173.16 74.1, 91.77 190.52, 2.48 -104.6, 25.15 318.27, 124.04 -54.52, -37.44 in-in in 9.223 Saltbr-in 2.607 HRD-na-N -72.86, -48.93 72.97, 0.92 in-in-na SNCiia in-na ActLoopNT-in 2.865 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.61, 13.68 APE9-dihe-na -74.05, 162.55 APE8-dihe-na -147.53, 161.22 APE8-rot-na 206.35 APE67-dihe-na -163.09, 139.78 96.44, 2.71 APE12-dist-na 9.496 APE11-dist-na 13.491 APE10-dist-na 16.919 APE9-dist-na 13.026 F605Y None None XRAY 1.45 0.159 0.175 A 357 328 0 0 0 0 [[484, 797]] 1.0 6g39 OTHER_HASPIN_HUMAN HASP 4e-226 755.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 2VUWA Q8TF76 470 798 798.0 5ID:1800 Type1 Active DFGin 4.977 12.344 BLAminus DFGAsp-rot-in -126.7, 172.42 73.13, 94.6 197.35, -11.33 -106.22, 25.34 317.03, 123.17 -59.06, -30.58 in-in in 9.293 Saltbr-in 2.791 HRD-na-N -69.06, -49.8 71.93, -0.86 in-in-na SNCiia in-na ActLoopNT-in 2.886 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.41, 21.25 APE9-dihe-na -74.65, 162.69 APE8-dihe-na -150.22, 164.21 APE8-rot-na 197.92 APE67-dihe-na -163.26, 143.62 93.5, 5.23 APE12-dist-na 9.51 APE11-dist-na 13.492 APE10-dist-na 17.046 APE9-dist-na 12.946 None None MSE615,MSE706,MSE725,MSE752,MSE756,MSE767,MSE781 XRAY 1.8 0.148 0.169 A 336 329 0 0 0 0 [[484, 797]] 1.0 2vuw OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.178 12.218 BLAminus DFGAsp-rot-in -141.02, 178.95 59.99, 70.73 184.73, 7.85 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.759 Saltbr-in 2.463 HRD-na-N -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.905 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.64 APE11-dist-na 13.509 APE10-dist-na 17.247 APE9-dist-na 13.279 None None None XRAY 2.4 0.187 0.239 A 336 320 8 0 0 0 [[484, 797]] 1.0 9flt OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3E7VA Q8TF76 471 798 798.0 DZO:1 Type1 Active DFGin 5.227 12.203 BLAminus DFGAsp-rot-in -130.14, 169.21 72.6, 84.89 205.6, 11.73 -101.25, 35.48 316.82, 123.9 -62.16, -34.97 in-in in 9.014 Saltbr-in 2.481 HRD-na-N -68.11, -48.56 71.09, -0.57 in-in-na SNCiia in-na ActLoopNT-in 2.917 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -113.43, 18.49 APE9-dihe-na -73.97, 165.86 APE8-dihe-na -158.09, 152.51 APE8-rot-na 206.55 APE67-dihe-na -159.89, 140.52 100.1, 0.81 APE12-dist-na 9.459 APE11-dist-na 13.36 APE10-dist-na 17.023 APE9-dist-na 12.905 None None None XRAY 2.0 0.17 0.225 A 357 328 0 0 0 0 [[484, 797]] 1.0 3e7v OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3F2NA Q8TF76 471 798 798.0 IZZ:800 Type1 Active DFGin 5.227 12.509 BLAminus DFGAsp-rot-in -132.35, 169.14 74.56, 87.66 192.8, -31.19 -98.09, 25.18 316.3, 125.75 -57.05, -34.51 in-in in 8.729 Saltbr-in 2.737 HRD-na-N -71.51, -49.79 70.28, -0.25 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -120.07, 21.25 APE9-dihe-na -75.2, 162.89 APE8-dihe-na -156.01, 176.32 APE8-rot-na 74.11 APE67-dihe-na -157.24, 143.14 98.22, -8.69 APE12-dist-na 9.565 APE11-dist-na 13.531 APE10-dist-na 17.149 APE9-dist-na 12.969 None None None XRAY 1.8 0.162 0.186 A 357 328 0 0 0 0 [[484, 797]] 1.0 3f2n OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3FMDA Q8TF76 470 798 798.0 IQB:1 Type1 Active DFGin 4.817 12.737 BLAminus DFGAsp-rot-in -134.95, 173.12 69.12, 93.36 201.31, -6.37 -108.33, 23.11 309.03, 122.86 -58.61, -32.84 in-in in 9.417 Saltbr-in 2.578 HRD-na-N -64.91, -44.59 67.0, -1.51 in-in-na SNCiia in-na ActLoopNT-in 2.86 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -126.4, 30.5 APE9-dihe-na -82.22, 168.97 APE8-dihe-na -156.73, 170.22 APE8-rot-na 87.7 APE67-dihe-na -158.09, 144.39 88.76, -6.79 APE12-dist-na 9.533 APE11-dist-na 13.423 APE10-dist-na 17.115 APE9-dist-na 13.017 None None None XRAY 2.0 0.226 0.283 A 357 329 0 0 0 0 [[484, 797]] 1.0 3fmd OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3IQ7A Q8TF76 471 798 798.0 5ID:799 Type1 Active DFGin 5.002 12.525 BLAminus DFGAsp-rot-in -130.14, 168.59 78.5, 93.8 191.01, 4.6 -107.03, 26.88 317.14, 123.36 -63.63, -28.13 in-in in 9.288 Saltbr-in 2.716 HRD-na-N -69.08, -54.14 69.34, 3.59 in-in-na SNCiia in-na ActLoopNT-in 2.842 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -119.96, 19.66 APE9-dihe-na -73.26, 163.53 APE8-dihe-na -151.13, 165.69 APE8-rot-na 217.79 APE67-dihe-na -160.55, 141.37 91.74, 4.08 APE12-dist-na 9.31 APE11-dist-na 13.171 APE10-dist-na 16.954 APE9-dist-na 12.798 None None None XRAY 2.0 0.174 0.207 A 357 328 0 0 0 0 [[484, 797]] 1.0 3iq7 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 4OUCA Q8TF76 470 798 798.0 5ID:60808 Type1 Active DFGin 5.142 12.398 BLAminus DFGAsp-rot-in -123.14, 171.36 70.83, 89.85 195.48, -4.24 -103.14, 24.75 317.85, 126.13 -50.7, -43.23 in-in in 9.227 Saltbr-in 2.635 HRD-na-N -73.5, -49.82 73.73, 4.15 in-in-na SNCiia in-na ActLoopNT-in 2.897 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.93, 10.97 APE9-dihe-na -70.72, 155.25 APE8-dihe-na -144.93, 165.92 APE8-rot-na 81.62 APE67-dihe-na -154.34, 142.15 101.34, -0.24 APE12-dist-na 9.521 APE11-dist-na 13.627 APE10-dist-na 17.119 APE9-dist-na 12.997 None None None XRAY 1.9 0.166 0.211 A 357 329 0 0 0 0 [[484, 797]] 1.0 4ouc OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 4QTCA Q8TF76 469 798 798.0 38Z:804 Type1 Active DFGin 4.743 12.697 BLAminus DFGAsp-rot-in -128.25, 174.11 72.8, 94.29 184.0, 9.68 -100.86, 22.55 311.48, 126.56 -49.88, -46.32 in-in in 9.244 Saltbr-in 2.767 HRD-na-N -70.64, -49.71 73.49, 0.07 in-in-na SNCiia in-na ActLoopNT-in 2.862 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.14, 15.58 APE9-dihe-na -74.4, 166.34 APE8-dihe-na -155.61, 167.98 APE8-rot-na 54.8 APE67-dihe-na -159.6, 141.49 96.89, -1.32 APE12-dist-na 9.4 APE11-dist-na 13.293 APE10-dist-na 16.89 APE9-dist-na 13.142 None None None XRAY 1.4 0.15 0.164 A 357 330 0 0 0 0 [[484, 797]] 1.0 4qtc OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G34A Q8TF76 472 798 798.0 5ID:60401 Type1 Active DFGin 4.991 12.367 BLAminus DFGAsp-rot-in -127.35, 171.15 74.89, 93.11 193.36, -5.12 -104.99, 26.96 316.16, 126.1 -57.37, -32.12 in-in in 9.292 Saltbr-in 2.721 HRD-na-N -71.53, -47.32 70.63, -2.3 in-in-na SNCiia in-na ActLoopNT-in 2.893 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.68, 18.32 APE9-dihe-na -70.1, 157.86 APE8-dihe-na -146.1, 158.98 APE8-rot-na 202.21 APE67-dihe-na -162.15, 141.91 96.58, 0.13 APE12-dist-na 9.436 APE11-dist-na 13.462 APE10-dist-na 16.952 APE9-dist-na 12.837 None None None XRAY 1.76 0.14 0.174 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g34 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G35A Q8TF76 465 798 798.0 EKK:60802 Type1 Active DFGin 5.005 12.39 BLAminus DFGAsp-rot-in -126.0, 169.52 78.13, 90.25 192.22, 1.12 -104.66, 24.26 315.74, 125.01 -60.88, -28.25 in-in in 9.306 Saltbr-in 2.713 HRD-na-N -70.57, -49.54 72.42, 1.39 in-in-na SNCiia in-na ActLoopNT-in 2.901 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.32, 17.8 APE9-dihe-na -73.2, 161.57 APE8-dihe-na -146.96, 162.71 APE8-rot-na 196.59 APE67-dihe-na -162.63, 137.82 97.88, 1.51 APE12-dist-na 9.478 APE11-dist-na 13.461 APE10-dist-na 17.008 APE9-dist-na 13.016 None None None XRAY 1.55 0.161 0.183 A 357 334 0 0 0 0 [[484, 797]] 1.0 6g35 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G36A Q8TF76 465 798 798.0 EKH:60401 Type1 Active DFGin 4.952 12.328 BLAminus DFGAsp-rot-in -126.44, 170.29 76.27, 92.19 194.23, -9.74 -105.23, 26.61 316.28, 124.1 -57.25, -32.63 in-in in 9.282 Saltbr-in 2.744 HRD-na-N -71.83, -48.64 74.84, -0.58 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.55, 15.17 APE9-dihe-na -70.08, 160.85 APE8-dihe-na -149.64, 167.11 APE8-rot-na 67.1 APE67-dihe-na -162.45, 137.7 92.15, 4.46 APE12-dist-na 9.491 APE11-dist-na 13.449 APE10-dist-na 17.015 APE9-dist-na 12.972 None None None XRAY 1.46 0.151 0.176 A 357 334 0 0 0 0 [[484, 797]] 1.0 6g36 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G37A Q8TF76 472 798 798.0 FTU:801 Type1 Active DFGin 5.035 12.401 BLAminus DFGAsp-rot-in -125.49, 171.67 75.49, 90.88 194.91, -8.41 -104.56, 25.99 317.99, 122.48 -54.51, -35.12 in-in in 9.318 Saltbr-in 2.736 HRD-na-N -70.97, -50.1 72.78, 2.06 in-in-na SNCiia in-na ActLoopNT-in 2.889 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.17, 14.96 APE9-dihe-na -72.53, 161.37 APE8-dihe-na -147.52, 165.41 APE8-rot-na 216.83 APE67-dihe-na -159.62, 143.17 92.11, 0.24 APE12-dist-na 9.422 APE11-dist-na 13.433 APE10-dist-na 16.884 APE9-dist-na 12.914 None None None XRAY 1.48 0.149 0.167 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g37 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G38A Q8TF76 472 798 798.0 TBN:800 Type1 Active DFGin 5.155 12.468 BLAminus DFGAsp-rot-in -124.6, 171.17 73.49, 90.96 197.82, -19.25 -102.58, 23.98 318.22, 128.64 -60.91, -27.39 in-in in 9.286 Saltbr-in 2.681 HRD-na-N -70.12, -48.6 70.78, 0.07 in-in-na SNCiia in-na ActLoopNT-in 2.865 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.63, 17.26 APE9-dihe-na -74.94, 161.54 APE8-dihe-na -150.43, 171.99 APE8-rot-na 81.52 APE67-dihe-na -161.74, 140.31 94.52, 1.17 APE12-dist-na 9.54 APE11-dist-na 13.547 APE10-dist-na 17.024 APE9-dist-na 13.008 None None None XRAY 1.47 0.144 0.165 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g38 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z57A Q8TF76 470 798 798.0 Q8W:801 Type1 Active DFGin 5.108 12.544 BLAminus DFGAsp-rot-in -128.55, 170.14 70.49, 89.65 193.32, -5.8 -99.72, 23.55 319.85, 122.5 -60.24, -32.24 in-in in 9.047 Saltbr-in 2.63 HRD-na-N -69.51, -48.64 73.21, 1.64 in-in-na SNCiia in-na ActLoopNT-in 2.906 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.13, 24.13 APE9-dihe-na -80.04, 165.59 APE8-dihe-na -154.67, 168.36 APE8-rot-na 59.7 APE67-dihe-na -158.19, 141.65 89.15, 3.9 APE12-dist-na 9.623 APE11-dist-na 13.634 APE10-dist-na 17.184 APE9-dist-na 13.001 None None None XRAY 1.5 0.164 0.188 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z57 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z58A Q8TF76 470 798 798.0 Q9B:801 Type1 Active DFGin 5.29 11.882 BLAminus DFGAsp-rot-in -131.62, 178.98 63.69, 89.83 194.02, -3.26 -101.06, 25.15 318.41, 128.59 -53.25, -41.36 in-in in 8.999 Saltbr-in 2.668 HRD-na-N -74.24, -49.55 73.51, 2.01 in-in-na SNCiia in-na ActLoopNT-in 2.86 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.26, 20.54 APE9-dihe-na -78.55, 163.28 APE8-dihe-na -149.94, 172.24 APE8-rot-na 51.88 APE67-dihe-na -158.7, 145.23 97.38, -8.51 APE12-dist-na 9.654 APE11-dist-na 13.592 APE10-dist-na 17.186 APE9-dist-na 13.103 None None None XRAY 1.8 0.164 0.19 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z58 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z59A Q8TF76 471 798 798.0 Q98:801 Type1 Active DFGin 5.136 12.054 BLAminus DFGAsp-rot-in -130.43, 175.42 66.1, 93.37 197.62, -1.34 -104.47, 26.06 315.68, 130.09 -58.56, -40.67 in-in in 9.082 Saltbr-in 2.794 HRD-na-N -73.99, -49.28 75.88, 2.33 in-in-na SNCiia in-na ActLoopNT-in 2.831 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.38, 14.19 APE9-dihe-na -67.33, 158.61 APE8-dihe-na -154.66, -177.03 APE8-rot-na 74.44 APE67-dihe-na -159.78, 146.47 89.13, -0.56 APE12-dist-na 9.712 APE11-dist-na 13.618 APE10-dist-na 17.166 APE9-dist-na 12.987 None None None XRAY 2.0 0.201 0.24 A 357 328 0 0 0 0 [[484, 797]] 1.0 6z59 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5CA Q8TF76 470 798 798.0 PQ5:805 Type1 Inactive DFGin 4.731 13.108 BLAminus DFGAsp-rot-in -133.84, 170.31 75.72, 94.52 187.57, -0.13 -110.21, 19.19 311.37, 116.86 -61.87, -31.19 out-out out 10.462 Saltbr-out 3.7 HRD-na-N -70.06, -50.84 74.01, -0.31 out-in-na SNCoia in-na ActLoopNT-in 2.931 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.88, 20.45 APE9-dihe-na -80.43, 159.13 APE8-dihe-na -144.39, 165.92 APE8-rot-na 214.89 APE67-dihe-na -162.19, 147.1 97.48, -3.07 APE12-dist-na 9.488 APE11-dist-na 13.52 APE10-dist-na 17.05 APE9-dist-na 13.1 None None None XRAY 1.75 0.16 0.188 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z5c OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5DA Q8TF76 470 798 798.0 Q8Q:805 Type1 Active DFGin 5.053 12.308 BLAminus DFGAsp-rot-in -128.1, 170.45 73.65, 93.08 192.23, 0.69 -105.2, 21.18 315.55, 125.26 -62.8, -29.15 in-in in 9.073 Saltbr-in 2.688 HRD-na-N -71.9, -46.78 72.06, -1.5 in-in-na SNCiia in-na ActLoopNT-in 2.861 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.04, 23.91 APE9-dihe-na -77.44, 160.96 APE8-dihe-na -149.27, 168.07 APE8-rot-na 78.22 APE67-dihe-na -158.56, 145.68 94.91, -2.03 APE12-dist-na 9.558 APE11-dist-na 13.567 APE10-dist-na 17.139 APE9-dist-na 13.019 None None None XRAY 1.75 0.154 0.178 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z5d OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5EA Q8TF76 471 798 798.0 Q8K:806 Type1 Active DFGin 5.08 12.459 BLAminus DFGAsp-rot-in -128.44, 172.31 71.81, 90.69 187.44, 7.51 -103.13, 26.31 316.73, 125.57 -64.15, -28.51 in-in in 9.143 Saltbr-in 2.729 HRD-na-N -68.18, -49.54 73.75, 2.15 in-in-na SNCiia in-na ActLoopNT-in 2.888 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.8, 21.0 APE9-dihe-na -73.94, 160.68 APE8-dihe-na -150.44, 166.42 APE8-rot-na 75.48 APE67-dihe-na -157.25, 143.6 92.62, -2.15 APE12-dist-na 9.572 APE11-dist-na 13.485 APE10-dist-na 17.146 APE9-dist-na 12.936 None None None XRAY 1.5 0.159 0.183 A 357 328 0 0 0 0 [[484, 797]] 1.0 6z5e OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7AVQA Q8TF76 471 798 798.0 S1Z:801 Type1 Active DFGin 5.149 12.146 BLAminus DFGAsp-rot-in -126.06, 173.12 69.03, 91.95 189.42, 3.8 -102.42, 24.12 320.3, 125.97 -52.79, -41.95 in-in in 8.998 Saltbr-in 2.659 HRD-na-N -75.14, -46.38 71.99, 2.8 in-in-na SNCiia in-na ActLoopNT-in 2.891 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.18, 22.84 APE9-dihe-na -73.32, 160.09 APE8-dihe-na -148.12, 160.7 APE8-rot-na 195.64 APE67-dihe-na -157.46, 142.25 95.7, -0.72 APE12-dist-na 9.574 APE11-dist-na 13.487 APE10-dist-na 17.118 APE9-dist-na 12.952 None None None XRAY 1.65 0.16 0.179 A 357 328 0 0 0 0 [[484, 797]] 1.0 7avq OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7OPSA Q8TF76 471 798 798.0 07C:801 Type1 Active DFGin 4.955 12.409 BLAminus DFGAsp-rot-in -120.84, 168.72 74.52, 94.25 185.82, 11.38 -110.46, 32.79 314.75, 129.03 -72.39, -27.54 in-in in 9.209 Saltbr-in 2.891 HRD-na-N -67.82, -53.79 76.87, 1.09 in-in-na SNCiia in-na ActLoopNT-in 2.935 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.38, 10.26 APE9-dihe-na -73.55, 156.67 APE8-dihe-na -147.73, 179.58 APE8-rot-na 67.78 APE67-dihe-na -167.67, 141.52 97.91, 1.48 APE12-dist-na 9.463 APE11-dist-na 13.499 APE10-dist-na 16.964 APE9-dist-na 13.035 None None None XRAY 2.38 0.179 0.229 A 357 328 0 0 0 0 [[484, 797]] 1.0 7ops OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 8RDKA Q8TF76 471 798 798.0 YQT:803 Type1 Active DFGin 5.304 12.291 BLAminus DFGAsp-rot-in -126.79, 170.58 68.55, 97.1 186.08, 1.43 -105.65, 24.46 315.14, 130.76 -63.91, -28.61 in-in in 8.949 Saltbr-in 2.684 HRD-na-N -70.8, -52.97 75.33, 1.85 in-in-na SNCiia in-na ActLoopNT-in 2.843 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.88, 25.66 APE9-dihe-na -78.67, 156.59 APE8-dihe-na -150.7, 178.52 APE8-rot-na 74.04 APE67-dihe-na -162.89, 139.09 96.18, -5.83 APE12-dist-na 9.438 APE11-dist-na 13.401 APE10-dist-na 17.106 APE9-dist-na 12.963 None None None XRAY 2.0 0.199 0.233 A 357 328 0 0 0 0 [[484, 797]] 1.0 8rdk OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLBA Q8TF76 471 798 798.0 A1IDB:802 Type1 Active DFGin 5.017 12.499 BLAminus DFGAsp-rot-in -122.75, 164.93 78.09, 95.44 183.51, 10.74 -111.48, 32.7 311.33, 133.52 -69.25, -37.29 in-in in 8.846 Saltbr-in 2.663 HRD-na-N -65.06, -57.81 86.13, 3.33 in-in-na SNCiia in-na ActLoopNT-in 2.883 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -97.12, -24.47 APE9-dihe-na -48.97, 165.86 APE8-dihe-na -171.41, -171.26 APE8-rot-na 65.27 APE67-dihe-na -131.18, 150.53 102.5, -31.2 APE12-dist-na 9.656 APE11-dist-na 13.445 APE10-dist-na 16.901 APE9-dist-na 13.075 None None None XRAY 2.5 0.195 0.245 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flb OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLOA Q8TF76 466 797 798.0 A1IDC:802 Type1 Inactive DFGin 5.355 12.318 BLAminus DFGAsp-rot-in -140.34, 174.89 75.76, 76.52 186.81, 36.04 -89.13, 31.66 305.79, 159.49 -77.78, -25.85 in-out in 9.084 Saltbr-out 3.76 HRD-na-N -85.47, -46.33 68.95, 25.87 out-in-na SNCoia in-na ActLoopNT-in 2.616 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.51, 102.44 APE9-dihe-na 136.93, 133.28 APE8-dihe-na -151.7, -143.81 APE8-rot-na 72.42 APE67-dihe-na -90.21, 160.33 109.28, -71.54 APE12-dist-na 9.638 APE11-dist-na 13.586 APE10-dist-na 17.18 APE9-dist-na 14.433 None None None XRAY 2.9 0.214 0.247 A 357 332 0 0 0 0 [[484, 797]] 1.0 9flo OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLQA Q8TF76 471 798 798.0 A1IDD:806 Type1 Active DFGin 5.277 11.995 BLAminus DFGAsp-rot-in -131.52, 170.51 72.45, 91.56 190.19, 7.41 -104.74, 27.71 313.77, 132.43 -58.36, -40.16 in-in in 9.194 Saltbr-in 2.385 HRD-na-N -72.62, -50.16 74.03, 2.04 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -123.97, 17.68 APE9-dihe-na -77.54, 163.56 APE8-dihe-na -154.04, 168.58 APE8-rot-na 56.93 APE67-dihe-na -156.8, 141.47 98.45, -3.96 APE12-dist-na 9.579 APE11-dist-na 13.504 APE10-dist-na 17.048 APE9-dist-na 13.042 None None None XRAY 1.85 0.176 0.202 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flq OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLRA Q8TF76 471 798 798.0 A1IDE:803 Type1 Active DFGin 5.257 11.905 BLAminus DFGAsp-rot-in -132.45, 173.37 67.71, 90.56 186.48, 4.45 -101.27, 25.05 315.0, 128.67 -53.75, -42.86 in-in in 9.406 Saltbr-in 2.535 HRD-na-N -70.9, -52.21 71.26, 4.74 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.29, 14.34 APE9-dihe-na -78.07, 164.28 APE8-dihe-na -157.67, 170.99 APE8-rot-na 58.59 APE67-dihe-na -164.88, 135.66 97.12, 4.81 APE12-dist-na 9.597 APE11-dist-na 13.566 APE10-dist-na 17.045 APE9-dist-na 13.109 None None None XRAY 1.91 0.173 0.209 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flr OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7SQMA Q8TF76 453 798 798.0 A5G:801 Type1 Active DFGin 5.294 12.385 BLAminus DFGAsp-rot-in -126.59, 168.89 78.77, 90.66 180.07, 13.19 -103.22, 31.48 318.95, 126.98 -62.97, -29.65 in-in in 9.033 Saltbr-in 2.862 HRD-na-N -74.3, -49.72 73.45, 2.57 in-in-na SNCiia in-na ActLoopNT-in 2.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.03, 13.48 APE9-dihe-na -73.56, 163.48 APE8-dihe-na -150.66, 160.36 APE8-rot-na 211.61 APE67-dihe-na -164.54, 145.89 99.66, 4.4 APE12-dist-na 9.225 APE11-dist-na 13.189 APE10-dist-na 16.762 APE9-dist-na 12.944 None None None XRAY 1.78 0.175 0.205 A 357 346 0 0 0 0 [[484, 797]] 1.0 7sqm OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G3AA Q8TF76 471 798 798.0 5ID:805 Type1 Inactive DFGin 4.953 12.443 BLAminus DFGAsp-rot-in -127.41, 171.94 74.51, 93.23 192.28, -29.64 -106.28, 26.81 312.44, 123.45 -60.95, -29.67 in-out in 9.904 Saltbr-out 4.42 HRD-na-N -72.27, -48.82 73.62, 1.17 out-in-na SNCoia in-na ActLoopNT-in 2.883 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.57, 14.66 APE9-dihe-na -70.85, 159.17 APE8-dihe-na -152.35, 172.74 APE8-rot-na 72.92 APE67-dihe-na -156.95, 142.2 92.44, -2.34 APE12-dist-na 9.454 APE11-dist-na 13.382 APE10-dist-na 16.931 APE9-dist-na 12.993 F605T None None XRAY 1.43 0.151 0.175 A 357 328 0 0 0 0 [[484, 797]] 1.0 6g3a OTHER_HASPIN_HUMAN HASP 1.9e-225 752.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9WGWA Q8TF76 453 798 798.0 A1MBI:801 Type1 Active DFGin 5.138 12.385 BLAminus DFGAsp-rot-in -147.7705, 172.4382 70.4778, 95.7674 203.5976, 0.5146 -111.9455, 33.2101 314.8585, 135.6302 -68.9733, -26.4338 in-in in 9.192 Saltbr-in 2.955 HRD-na-N -85.9524, -56.4798 80.5641, -2.245 in-in-na SNCiia in-na ActLoopNT-in 2.988 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.0366, 23.0374 APE9-dihe-na -79.009, 160.4727 APE8-dihe-na -154.9969, 152.9549 APE8-rot-na 52.2748 APE67-dihe-na -158.7033, 149.5673 113.8591, -8.888 APE12-dist-na 9.43 APE11-dist-na 13.164 APE10-dist-na 16.931 APE9-dist-na 12.563 None None None XRAY 2.7 0.208 0.235 A 798 346 0 0 0 0 [[484, 797]] 1.0 9wgw OTHER_HASPIN_HUMAN HASP 1.4e-225 753.5 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z56A Q8TF76 470 798 798.0 Q7Q:801 Type1.5_Back Inactive DFGin 4.602 12.569 BLAminus DFGAsp-rot-in -129.58, 171.28 69.16, 102.48 183.06, 16.09 -109.85, 26.06 309.6, 123.99 -45.33, -46.61 out-out out 10.104 Saltbr-out 4.52 HRD-na-N -69.89, -50.01 74.0, -0.03 out-in-na SNCoia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -120.86, 18.07 APE9-dihe-na -73.34, 162.1 APE8-dihe-na -143.73, 169.15 APE8-rot-na 201.43 APE67-dihe-na -162.09, 141.44 91.95, 4.24 APE12-dist-na 9.424 APE11-dist-na 13.25 APE10-dist-na 17.008 APE9-dist-na 13.071 None None None XRAY 1.9 0.178 0.221 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z56 OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5BA Q8TF76 469 798 798.0 Q7Z:803 Type1.5_Back Inactive DFGin 4.548 12.709 BLAminus DFGAsp-rot-in -135.9, 170.26 70.64, 101.28 193.87, -5.45 -110.64, 25.44 308.83, 121.13 -45.93, -45.39 out-out out 10.049 Saltbr-out 4.556 HRD-na-N -70.65, -51.98 77.17, -0.49 out-in-na SNCoia in-na ActLoopNT-in 2.906 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.59, 17.24 APE9-dihe-na -73.9, 162.49 APE8-dihe-na -150.9, 168.36 APE8-rot-na 77.43 APE67-dihe-na -163.72, 140.01 97.4, -1.55 APE12-dist-na 9.36 APE11-dist-na 13.278 APE10-dist-na 16.905 APE9-dist-na 12.945 None None None XRAY 1.9 0.157 0.198 A 357 330 0 0 0 0 [[484, 797]] 1.0 6z5b OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLCA Q8TF76 471 798 798.0 A1IDA:801 Type1.5_Back Active DFGin 4.715 12.46 BLAminus DFGAsp-rot-in -134.34, 171.12 67.31, 104.11 186.96, -4.21 -111.35, 24.44 309.33, 129.38 -43.69, -56.59 in-in in 9.127 Saltbr-in 2.572 HRD-na-N -70.37, -50.71 74.43, 4.41 in-in-na SNCiia in-na ActLoopNT-in 2.846 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -124.8, 13.59 APE9-dihe-na -68.86, 164.74 APE8-dihe-na -159.81, 175.83 APE8-rot-na 49.95 APE67-dihe-na -162.39, 140.7 102.66, -4.36 APE12-dist-na 9.337 APE11-dist-na 13.24 APE10-dist-na 16.865 APE9-dist-na 12.997 None None None XRAY 2.18 0.166 0.197 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flc OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5AA Q8TF76 465 798 798.0 Q8B:60807 Type1.5_Front Inactive DFGin 4.746 13.158 BLAminus DFGAsp-rot-in -130.52, 170.23 77.78, 97.19 195.47, -11.53 -110.55, 22.86 309.49, 126.33 -50.19, -42.61 out-out out 10.928 Saltbr-out 6.049 HRD-na-N -69.87, -51.48 73.76, 2.92 out-in-na SNCoia in-na ActLoopNT-in 2.957 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.05, 16.57 APE9-dihe-na -70.55, 162.23 APE8-dihe-na -152.03, 159.2 APE8-rot-na 218.93 APE67-dihe-na -157.88, 144.9 96.43, 3.83 APE12-dist-na 9.408 APE11-dist-na 13.313 APE10-dist-na 16.953 APE9-dist-na 12.968 None None None XRAY 1.55 0.157 0.182 A 357 334 0 0 0 0 [[484, 797]] 1.0 6z5a OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2TK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 10.473 16.998 None DFGAsp-rot-out -74.01, 167.84 -68.22, 151.89 61.93, -23.26 -112.4, 131.65 323.3, 85.18 -72.17, -31.47 out-out out 10.371 Saltbr-out 8.739 HRD-na-N -90.05, -46.55 60.89, 17.99 out-in-na SNCoia in-na ActLoopNT-in 2.509 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -99.75, 7.12 APE9-dihe-na -76.13, 178.32 APE8-dihe-na -157.85, 172.7 APE8-rot-na 78.9 APE67-dihe-na -161.94, 175.92 118.79, -26.14 APE12-dist-na 11.19 APE11-dist-na 13.535 APE10-dist-na 18.064 APE9-dist-na 14.027 None None None EM 2.99 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2t OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER IKBKB IKKB_HUMAN AF-O14920-K1A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.752 12.489 BLAminus DFGAsp-rot-in -126.26, 179.48 57.5, 66.07 198.61, 22.06 -76.3, 19.61 299.61, 8.49 -59.99, -32.45 in-in in 8.239 Saltbr-in 2.629 HRD-in -81.33, -51.39 65.56, 14.54 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.53, 154.84 APE9-dihe-na 116.37, 176.3 APE8-dihe-in -92.66, 124.92 APE8-rot-in 300.66 APE67-dihe-in -71.88, -14.8 -44.22, -44.73 APE12-dist-in 8.696 APE11-dist-in 11.305 APE10-dist-in 5.518 APE9-dist-in 3.404 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[15, 449]] 1.0 AF-O14920-K1 OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN AF-O14920-K3A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.582 12.343 BLAminus DFGAsp-rot-in -132.39, 175.64 61.02, 71.13 201.71, -3.05 -79.51, 18.58 302.46, 7.63 -62.8, -20.15 in-in in 8.281 Saltbr-in 2.673 HRD-in -75.95, -49.61 66.27, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.0, 159.82 APE9-dihe-na 103.19, -179.04 APE8-dihe-in -94.98, 120.71 APE8-rot-in 301.22 APE67-dihe-in -70.58, -17.32 -47.51, -36.7 APE12-dist-in 8.765 APE11-dist-in 11.122 APE10-dist-in 5.289 APE9-dist-in 3.445 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[15, 449]] 1.0 AF-O14920-K3 OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CB O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.723 12.416 BLAminus DFGAsp-rot-in -105.72, -155.63 -11.15, 130.65 190.09, -71.78 -122.44, 23.83 259.84, 47.47 -53.22, -19.06 in-in in 8.472 Saltbr-in 2.771 HRD-in -75.6, -33.93 66.41, -70.8 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -41.33, 120.77 APE9-dihe-na 145.43, -135.28 APE8-dihe-in -71.19, 72.96 APE8-rot-in 313.16 APE67-dihe-out 41.01, -82.54 -50.74, -88.53 APE12-dist-in 8.168 APE11-dist-out 7.777 APE10-dist-out 11.469 APE9-dist-out 12.762 S177E,S181E None None XRAY 3.98 0.267 0.299 B 669 632 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CC O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.705 12.348 BLAminus DFGAsp-rot-in -106.09, -155.19 -11.21, 130.09 189.67, -71.68 -121.05, 26.29 258.84, 49.2 -40.6, -84.85 in-in in 8.462 Saltbr-in 2.761 HRD-in -71.79, -36.13 68.15, -71.55 in-in-out SNCiio in-out ActLoopNT-in 2.652 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -85.59, 121.05 APE9-dihe-na 114.45, 160.33 APE8-dihe-out -45.72, -30.46 APE8-rot-out 41.29 APE67-dihe-out -70.56, -0.85 47.27, 14.31 APE12-dist-in 8.111 APE11-dist-in 10.92 APE10-dist-out 8.156 APE9-dist-out 11.15 S177E,S181E None None XRAY 3.98 0.267 0.299 C 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CD O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.797 12.462 BLAminus DFGAsp-rot-in -105.23, -154.26 -12.01, 129.89 190.09, -70.47 -121.15, 31.39 257.96, 46.78 -48.12, -73.54 in-in in 8.471 Saltbr-in 2.748 HRD-in -71.85, -36.56 68.87, -68.74 in-in-out SNCiio in-out ActLoopNT-in 2.707 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.45, 136.63 APE9-dihe-na 128.45, -179.44 APE8-dihe-in -65.09, 82.14 APE8-rot-in 325.06 APE67-dihe-in -46.95, -54.94 -65.9, -0.17 APE12-dist-out 6.672 APE11-dist-in 10.406 APE10-dist-out 10.242 APE9-dist-out 11.628 S177E,S181E None None XRAY 3.98 0.267 0.299 D 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CF O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.696 12.471 BLAminus DFGAsp-rot-in -105.36, -154.55 -11.85, 129.86 189.97, -71.31 -122.15, 25.59 260.49, 46.17 -49.15, -47.61 in-in in 8.513 Saltbr-in 2.773 HRD-in -73.41, -32.98 66.19, -71.94 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -67.61, 80.78 APE9-dihe-na 112.37, -167.24 APE8-dihe-in -59.27, 163.67 APE8-rot-in 314.68 APE67-dihe-in -41.53, -27.23 -138.25, 21.39 APE12-dist-in 9.399 APE11-dist-in 9.604 APE10-dist-out 8.526 APE9-dist-out 13.012 S177E,S181E None None XRAY 3.98 0.267 0.299 F 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVC O14920 12 664 756.0 No_ligand No_ligand Inactive DFGin 8.096 11.319 BLAminus DFGAsp-rot-out -107.88, 165.55 59.11, 66.52 314.49, -16.8 -75.63, 95.07 269.65, 121.32 -77.03, -67.33 in-out in 8.49 Saltbr-out 6.423 HRD-in -72.03, -37.96 70.51, -11.08 out-out-out SNCooo out-out ActLoopNT-out 4.088 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 160.41 APE9-dihe-na 157.46, -124.88 APE8-dihe-in -136.31, 148.05 APE8-rot-out 62.18 APE67-dihe-out -121.08, -66.51 -95.21, 70.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.959 APE9-dist-out 9.509 S177E,S181E None None XRAY 4.16 0.259 0.299 C 671 630 13 0 0 7 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVD O14920 6 665 756.0 No_ligand No_ligand Inactive DFGin 7.863 11.936 BLAminus DFGAsp-rot-in -105.3, 164.79 60.63, 66.88 194.88, 18.54 -81.0, 63.33 264.63, 107.01 -73.78, -34.0 in-out in 9.273 Saltbr-out 4.75 HRD-in -72.17, -36.92 69.94, -10.55 out-out-out SNCooo out-out ActLoopNT-out 4.334 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niio APE10-dihe-na -141.13, 136.52 APE9-dihe-na 129.04, 163.75 APE8-dihe-in -138.59, 89.42 APE8-rot-out 174.05 APE67-dihe-out -100.49, -35.82 -139.2, 164.47 APE12-dist-none 999.0 APE11-dist-in 11.291 APE10-dist-in 6.91 APE9-dist-out 9.065 S177E,S181E None None XRAY 4.16 0.259 0.299 D 671 638 12 0 0 8 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4KIKA O14920 9 663 756.0 KSA:60800 Type1 Inactive DFGin 6.178 12.724 BLAminus DFGAsp-rot-in -127.36, 175.43 56.16, 79.78 196.27, 41.08 -104.55, 41.64 323.18, 179.99 -47.28, 146.96 in-in in 8.463 Saltbr-in 2.985 HRD-in -64.56, -53.95 76.42, -28.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.34, -25.34 APE9-dihe-na -61.49, -48.74 APE8-dihe-out -60.84, -33.61 APE8-rot-out 70.5 APE67-dihe-in -55.1, -27.97 -77.97, -16.15 APE12-dist-out 22.378 APE11-dist-out 21.154 APE10-dist-out 23.562 APE9-dist-out 12.504 None SEP257 SEP257 XRAY 2.83 0.186 0.236 A 677 619 17 0 0 10 [[15, 449]] 1.0 4kik OTHER_IKBKB_HUMAN OTHER 1.2e-50 180.0 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4KIKB O14920 2 663 756.0 KSA:60700 Type1 Active DFGin 5.884 12.152 BLAminus DFGAsp-rot-in -125.87, 177.92 56.45, 91.03 199.0, 44.1 -106.12, 30.12 279.95, 121.49 -75.67, -15.82 in-in in 8.434 Saltbr-in 3.023 HRD-in -64.36, -54.26 72.29, -3.36 in-in-in SNCiii in-in ActLoopNT-in 3.074 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.33, 150.83 APE9-dihe-na 128.58, -160.18 APE8-dihe-in -124.05, 125.13 APE8-rot-in 284.23 APE67-dihe-in -62.44, -27.05 -45.7, -44.8 APE12-dist-in 7.899 APE11-dist-in 11.049 APE10-dist-in 5.068 APE9-dist-in 3.456 None SEP177,SEP181 SEP177,SEP181 XRAY 2.83 0.186 0.236 B 677 649 3 0 0 3 [[15, 449]] 1.0 4kik OTHER_IKBKB_HUMAN OTHER 1.2e-50 180.0 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVB O14920 8 664 756.0 No_ligand No_ligand Inactive DFGin 7.618 11.282 BLBminus DFGAsp-rot-out -108.54, 168.08 59.13, 68.65 311.73, -16.12 -71.93, 172.37 306.75, 9.62 -115.69, -132.64 in-out in 9.685 Saltbr-out 3.937 HRD-in -72.28, -37.94 70.43, -9.98 out-out-out SNCooo out-out ActLoopNT-out 5.592 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -5.22 APE9-dihe-na -138.83, -131.22 APE8-dihe-in -157.95, 113.56 APE8-rot-in 300.65 APE67-dihe-out -99.01, -1.05 179.64, 158.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.143 APE9-dist-out 9.763 S177E,S181E None None XRAY 4.16 0.259 0.299 B 671 641 16 0 0 9 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.929 12.514 None DFGAsp-rot-in -102.89, -152.86 -13.03, 129.81 189.48, -71.05 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.498 Saltbr-in 2.737 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.891 APE11-dist-in 11.383 APE10-dist-out 9.709 APE9-dist-out 11.52 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.95 12.284 None DFGAsp-rot-in -103.98, -153.14 -13.07, 129.81 189.13, -72.06 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.492 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.879 APE11-dist-in 9.547 APE10-dist-out 9.116 APE9-dist-out 10.795 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.536 10.902 None DFGAsp-rot-in -105.5, 166.4 59.46, 69.27 196.57, 16.99 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.168 Saltbr-out 4.713 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.551 APE11-dist-in 11.201 APE10-dist-in 7.793 APE9-dist-out 7.897 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671 566 10 0 0 3 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVA O14920 8 666 756.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -106.7, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.657 Saltbr-in 3.526 HRD-in -71.9, -36.83 70.31, -11.77 in-out-out SNCioo out-out ActLoopNT-out 4.062 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.13 APE8-dihe-out -137.8, 28.35 APE8-rot-in 324.42 APE67-dihe-in -67.65, -38.83 -135.68, -11.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.005 S177E,S181E None None XRAY 4.16 0.259 0.299 A 671 636 19 0 0 13 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKE IKKE_HUMAN AF-Q14164-K1A Q14164 1 312 716.0 No_ligand No_ligand Active DFGin 6.719 13.674 BLAminus DFGAsp-rot-in -143.72, 178.6 61.91, 66.59 193.87, 23.67 -79.37, 20.21 292.68, 88.79 -65.67, -20.94 in-in in 8.405 Saltbr-in 2.618 HRD-in -84.99, -48.65 65.45, 13.11 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 165.5 APE9-dihe-na 117.63, -179.67 APE8-dihe-in -111.9, 132.86 APE8-rot-in 300.02 APE67-dihe-in -68.11, -26.98 -47.69, -41.16 APE12-dist-in 8.642 APE11-dist-in 10.257 APE10-dist-in 4.67 APE9-dist-in 3.36 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 256]] 1.0 AF-Q14164-K1 OTHER_IKBKE_HUMAN STE 1e-42 152.4 1 218 218 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Inhibitor of nuclear factor kappa-B kinase subunit epsilon
OTHER IKBKE IKKE_HUMAN AF-Q14164-K3A Q14164 1 312 716.0 No_ligand No_ligand Active DFGin 6.547 14.109 BLAminus DFGAsp-rot-in -144.68, 175.81 61.0, 56.02 199.55, 13.66 -70.82, 14.62 292.13, 89.05 -61.78, -25.15 in-in in 8.199 Saltbr-in 2.672 HRD-in -79.5, -42.13 66.9, 7.05 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.76, 157.28 APE9-dihe-na 154.51, 174.08 APE8-dihe-in -85.01, 119.62 APE8-rot-in 307.91 APE67-dihe-in -71.75, -18.82 -50.25, -42.28 APE12-dist-in 8.759 APE11-dist-in 10.579 APE10-dist-in 7.187 APE9-dist-in 4.879 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 256]] 1.0 AF-Q14164-K3 OTHER_IKBKE_HUMAN STE 1e-42 152.4 1 218 218 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Inhibitor of nuclear factor kappa-B kinase subunit epsilon
OTHER MLKL MLKL_HUMAN 6O5ZA Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus DFGAsp-rot-none -137.01, -155.47 64.86, 62.95 999.0, 999.0 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUA Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus DFGAsp-rot-none -132.65, -169.61 81.08, 16.1 999.0, 999.0 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUB Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus DFGAsp-rot-none -140.29, -170.33 85.23, 13.17 999.0, 999.0 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7MONA Q8NB16 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus DFGAsp-rot-none -145.54, -169.15 78.1, 22.67 999.0, 999.0 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4MWIA Q8NB16 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus DFGAsp-rot-none -145.19, 176.51 81.47, 24.62 999.0, 999.0 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi OTHER_MLKL_HUMAN TKL 1.4e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6BWKA Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus DFGAsp-rot-none -134.48, -157.9 71.65, 72.71 999.0, 999.0 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk OTHER_MLKL_HUMAN TKL 7.9e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JW7A Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus DFGAsp-rot-none -135.55, -168.18 79.35, 51.65 999.0, 999.0 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 8SLZA Q8NB16 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus DFGAsp-rot-none -150.61, -167.39 68.99, 34.67 999.0, 999.0 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4M67A Q8NB16 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus DFGAsp-rot-none -139.33, 178.33 78.86, 30.59 999.0, 999.0 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 OTHER_MLKL_HUMAN TKL 1.4e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK6A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus DFGAsp-rot-none -140.9, -170.14 65.42, 43.61 999.0, 999.0 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 OTHER_MLKL_HUMAN TKL 2.8e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK5A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus DFGAsp-rot-none -141.79, -176.2 75.53, 28.55 999.0, 999.0 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 OTHER_MLKL_HUMAN TKL 4.1e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KO1A Q8NB16 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus DFGAsp-rot-none -140.42, -174.32 76.63, 35.3 999.0, 999.0 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6O5ZB Q8NB16 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None DFGAsp-rot-none -138.35, -166.14 -159.95, 69.78 999.0, 999.0 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJA Q8NB16 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-none -135.25, 171.18 -163.91, 150.5 999.0, 999.0 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJB Q8NB16 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-none -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MOS MOS_HUMAN AF-P00540-K1A P00540 52 346 346.0 No_ligand No_ligand Active DFGin 8.378 13.7 BLAminus DFGAsp-rot-in -142.02, 174.07 61.45, 67.1 199.62, 13.23 -80.49, 18.05 298.48, 89.77 -64.82, -14.32 in-in in 7.371 Saltbr-in 2.647 HRD-in -71.69, -43.77 65.35, -14.48 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.96, -177.81 APE9-dihe-na 96.18, 177.01 APE8-dihe-in -87.72, 117.81 APE8-rot-in 304.89 APE67-dihe-in -67.87, -17.37 -54.41, -40.47 APE12-dist-in 10.944 APE11-dist-in 8.043 APE10-dist-in 5.298 APE9-dist-in 4.026 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[52, 345]] 1.0 AF-P00540-K1 OTHER_MOS_HUMAN MOS 3.9e-169 567.5 1 292 292 218 219 220 222 224 87 106 110 198 200 199 201 261 249 244 243 242 241 240 239 238 140 Proto-oncogene serine/threonine-protein kinase mos
OTHER MOS MOS_HUMAN AF-P00540-K3A P00540 52 346 346.0 No_ligand No_ligand Active DFGin 9.264 13.809 BLAminus DFGAsp-rot-in -141.82, 174.52 57.26, 70.6 201.41, -23.51 -81.54, 16.13 289.96, 91.49 -66.55, -6.03 in-in in 7.005 Saltbr-in 2.652 HRD-in -85.36, -42.85 63.56, -7.38 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.35, 179.73 APE9-dihe-na 92.72, 163.94 APE8-dihe-in -92.75, 119.29 APE8-rot-in 309.64 APE67-dihe-in -73.52, -19.3 -59.74, -28.49 APE12-dist-in 7.746 APE11-dist-in 8.714 APE10-dist-in 5.828 APE9-dist-in 4.524 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[52, 345]] 1.0 AF-P00540-K3 OTHER_MOS_HUMAN MOS 3.9e-169 567.5 1 292 292 218 219 220 222 224 87 106 110 198 200 199 201 261 249 244 243 242 241 240 239 238 140 Proto-oncogene serine/threonine-protein kinase mos
OTHER PAN3 PAN3_HUMAN 9QTUA Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 7.629 12.618 BLBminus DFGAsp-rot-na -129.14, 168.31 55.8, 57.39 311.17, 999.0 -86.82, 126.91 289.05, 999.0 84.49, -7.45 out-na out 16.938 Saltbr-na 999.0 HRD-in -70.23, -48.45 52.51, 26.26 na-out-na SNCaoa out-na ActLoopNT-out 6.726 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.17, 133.94 APE9-dihe-na -139.77, 155.63 APE8-dihe-na -106.23, 3.84 APE8-rot-na 207.6 APE67-dihe-na -83.45, 50.15 -63.24, -21.41 APE12-dist-na 5.615 APE11-dist-na 8.587 APE10-dist-na 9.043 APE9-dist-na 15.452 None None None EM 4.6 999.0 999.0 A 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu OTHER_PAN3_HUMAN PAN3 3.6e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_HUMAN 9QTUB Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 8.263 12.02 BLBminus DFGAsp-rot-na -100.76, 176.11 56.23, 61.14 294.62, 999.0 -97.32, 152.4 308.88, 999.0 53.22, 50.35 out-na out 16.294 Saltbr-na 999.0 HRD-in -72.51, -40.23 43.56, 28.97 na-out-na SNCaoa out-na ActLoopNT-out 7.368 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.38, 114.43 APE9-dihe-na -132.3, 150.78 APE8-dihe-na -89.72, 17.82 APE8-rot-na 302.92 APE67-dihe-na -83.3, 51.22 -62.52, -39.08 APE12-dist-na 5.216 APE11-dist-na 8.336 APE10-dist-na 9.036 APE9-dist-na 16.012 None None None EM 4.6 999.0 999.0 B 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu OTHER_PAN3_HUMAN PAN3 3.6e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PBK TOPK_HUMAN AF-Q96KB5-K1A Q96KB5 24 322 322.0 No_ligand No_ligand Active DFGin 5.994 13.327 BLAminus DFGAsp-rot-in -130.77, 175.32 61.95, 66.54 207.3, -5.2 -79.12, 21.11 301.93, 999.0 -68.13, -16.97 in-in in 7.701 Saltbr-in 2.77 HRD-in -66.38, -50.09 86.37, -1.71 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.87, -59.74 APE9-dihe-na 54.35, -173.14 APE8-dihe-in -118.19, 132.59 APE8-rot-in 302.93 APE67-dihe-in -61.14, -23.31 -48.42, -50.72 APE12-dist-in 9.251 APE11-dist-in 8.938 APE10-dist-in 5.681 APE9-dist-in 3.201 None None None AF2 -1.0 1.0 1.0 A 299 299 0 0 0 0 [[32, 320]] 1.0 AF-Q96KB5-K1 OTHER_PBK_HUMAN TKL 9e-42 149.4 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN AF-Q96KB5-K3A Q96KB5 24 322 322.0 No_ligand No_ligand Active DFGin 5.983 13.276 BLAminus DFGAsp-rot-in -134.86, 175.35 64.16, 62.22 210.94, -23.46 -75.68, 21.4 299.34, 999.0 -72.93, -12.09 in-in in 7.744 Saltbr-in 2.821 HRD-in -68.53, -48.41 78.67, 9.77 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.76, -63.28 APE9-dihe-na 49.29, -168.42 APE8-dihe-in -120.47, 133.05 APE8-rot-in 307.14 APE67-dihe-in -58.71, -21.68 -53.0, -49.72 APE12-dist-in 9.506 APE11-dist-in 8.934 APE10-dist-in 5.491 APE9-dist-in 3.16 None None None AF2 -1.0 1.0 1.0 A 299 299 0 0 0 0 [[32, 320]] 1.0 AF-Q96KB5-K3 OTHER_PBK_HUMAN TKL 9e-42 149.4 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN 5J0AA Q96KB5 23 320 322.0 No_ligand No_ligand Inactive DFGin 6.807 27.493 BLBtrans DFGAsp-rot-in -120.83, 178.23 63.13, 46.26 200.31, 13.54 -77.68, 127.34 174.11, 999.0 -94.63, -173.86 out-out out 23.497 Saltbr-out 22.245 HRD-in -63.25, -61.27 89.24, -1.01 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.7, -53.99 APE9-dihe-na 50.9, -150.82 APE8-dihe-in -122.3, 115.82 APE8-rot-in 307.93 APE67-dihe-in -53.08, -19.22 -17.72, -67.97 APE12-dist-in 12.627 APE11-dist-in 12.569 APE10-dist-out 13.098 APE9-dist-in 3.036 T198E None None XRAY 2.74 0.222 0.271 A 300 298 0 0 0 0 [[32, 320]] 1.0 5j0a OTHER_PBK_HUMAN TKL 7.5e-42 149.6 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN 5J0AB Q96KB5 19 319 322.0 No_ligand No_ligand Inactive DFGin 6.882 26.843 BLBtrans DFGAsp-rot-in -128.2, 177.09 70.09, 37.25 205.22, 9.55 -75.07, 133.1 177.1, 999.0 -120.74, -176.84 out-out out 22.717 Saltbr-out 18.531 HRD-in -62.17, -46.14 110.68, -48.17 out-in-out SNCoio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -119.14, -51.77 APE9-dihe-na 53.77, -148.64 APE8-dihe-in -130.26, 121.96 APE8-rot-in 308.15 APE67-dihe-in -51.55, -28.41 -28.76, -64.16 APE12-dist-in 12.051 APE11-dist-in 12.632 APE10-dist-out 13.05 APE9-dist-in 3.443 T198E None None XRAY 2.74 0.222 0.271 B 304 301 0 0 0 0 [[32, 320]] 1.0 5j0a OTHER_PBK_HUMAN TKL 7.5e-42 149.6 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PDIK1L PDK1L_HUMAN AF-Q8N165-K1A Q8N165 1 339 341.0 No_ligand No_ligand Active DFGin 6.585 13.907 BLAminus DFGAsp-rot-in -137.15, -178.57 58.36, 73.02 201.32, 22.95 -84.69, 18.59 288.0, 79.49 -61.61, -32.71 in-in in 8.057 Saltbr-in 2.751 HRD-in -74.27, -44.77 67.87, -15.12 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.61, 163.48 APE9-dihe-na 97.44, -168.3 APE8-dihe-in -104.85, 120.14 APE8-rot-in 307.72 APE67-dihe-in -65.45, -11.27 -42.85, -46.29 APE12-dist-in 10.931 APE11-dist-in 12.119 APE10-dist-in 6.635 APE9-dist-in 3.759 None None None AF2 -1.0 1.0 1.0 A 339 339 0 0 0 0 [[8, 329]] 1.0 AF-Q8N165-K1 OTHER_PDIK1L_HUMAN OTHER 1.2e-45 162.0 1 254 254 189 190 191 193 195 37 53 57 161 163 162 164 239 228 223 222 221 220 219 218 217 120 Serine/threonine-protein kinase PDIK1L
OTHER PDIK1L PDK1L_HUMAN AF-Q8N165-K3A Q8N165 1 339 341.0 No_ligand No_ligand Active DFGin 6.498 13.847 BLAminus DFGAsp-rot-in -136.9, -174.95 57.07, 73.45 201.59, -5.32 -87.15, 14.58 289.02, 83.44 -59.4, -33.05 in-in in 8.091 Saltbr-in 2.717 HRD-in -75.79, -43.26 65.3, -15.24 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.14, 156.01 APE9-dihe-na 121.66, -171.47 APE8-dihe-in -103.05, 121.32 APE8-rot-in 306.28 APE67-dihe-in -61.81, -14.08 -46.48, -45.91 APE12-dist-in 10.511 APE11-dist-in 11.781 APE10-dist-in 6.228 APE9-dist-in 3.632 None None None AF2 -1.0 1.0 1.0 A 339 339 0 0 0 0 [[8, 329]] 1.0 AF-Q8N165-K3 OTHER_PDIK1L_HUMAN OTHER 1.2e-45 162.0 1 254 254 189 190 191 193 195 37 53 57 161 163 162 164 239 228 223 222 221 220 219 218 217 120 Serine/threonine-protein kinase PDIK1L
OTHER PEAK1 PEAK1_HUMAN 6BHCA Q9H792 1285 1743 1746.0 No_ligand No_ligand Pseudo DFGin 5.695 15.242 BLAminus DFGAsp-rot-in -137.03, -177.55 61.13, 81.47 190.91, 7.71 -100.07, 34.54 288.4, 76.8 -70.97, -28.29 out-na out 10.366 Saltbr-na 999.0 HRD-in -68.45, -48.56 69.76, 5.84 na-in-out SNCaio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.07 APE8-dihe-out -85.98, -28.63 APE8-rot-na 192.98 APE67-dihe-in -67.0, -16.19 -77.03, -7.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.508 S1542T None None XRAY 2.3 0.196 0.234 A 438 370 43 0 0 9 [[1319, 1673]] 1.0 6bhc OTHER_PEAK1_HUMAN PEAK 6.9e-47 571.2 1 94 322 1554 1555 1556 1558 1560 1359 1374 1378 1513 1515 1514 1516 1591 1580 1575 1574 1573 1572 1571 1570 1569 1464 Inactive tyrosine-protein kinase PEAK1
OTHER PIK3R4 A0JP11_HUMAN 9ZPDA A0JP11 40 1358 1358.0 No_ligand No_ligand Inactive DFGin 9.265 17.176 BLAminus DFGAsp-rot-out -124.24, 174.99 57.1, 61.91 297.05, -14.18 -69.29, 103.7 281.98, 74.95 -75.47, 98.95 out-out out 18.527 Saltbr-out 19.256 HRD-in -57.18, -53.38 88.68, -41.24 out-out-out SNCooo out-out ActLoopNT-out 9.016 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 63.11, 23.69 APE9-dihe-na -79.47, -6.7 APE8-dihe-out 76.63, 7.41 APE8-rot-na 300.76 APE67-dihe-out -128.97, 125.13 -77.5, 130.76 APE12-dist-out 15.103 APE11-dist-out 18.863 APE10-dist-out 21.599 APE9-dist-out 16.99 None None None EM 3.38 999.0 999.0 A 1445 1081 66 0 0 0 [[19, 321]] 1.0 9zpd OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHFA Q99570 14 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.316 15.926 BLBminus DFGAsp-rot-out -137.15, 164.9 65.91, 49.84 300.55, -22.02 -57.2, 122.9 277.63, 71.86 -84.62, 59.4 out-out out 18.109 Saltbr-out 17.236 HRD-out -96.05, 90.63 -67.78, 11.21 out-out-out SNCooo out-out ActLoopNT-out 9.113 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 62.11, 44.99 APE9-dihe-na -103.33, -9.73 APE8-dihe-out 66.79, 8.06 APE8-rot-na 292.08 APE67-dihe-out -138.42, 103.87 -64.74, 143.63 APE12-dist-out 14.437 APE11-dist-out 18.408 APE10-dist-out 20.977 APE9-dist-out 15.949 None None None EM 2.73 999.0 999.0 A 1409 1179 27 0 0 0 [[19, 321]] 1.0 9mhf OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHGA Q99570 2 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.585 16.209 BLBminus DFGAsp-rot-out -138.69, 173.76 59.25, 52.03 300.11, -26.18 -58.14, 130.77 283.01, 77.56 -95.81, 48.2 out-out out 18.272 Saltbr-out 21.234 HRD-in -80.12, -61.33 90.81, -7.5 out-out-out SNCooo out-out ActLoopNT-out 9.246 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.37, 16.6 APE9-dihe-na -78.09, -5.34 APE8-dihe-out 69.83, -1.25 APE8-rot-na 218.72 APE67-dihe-out -116.55, 112.58 -66.54, 126.46 APE12-dist-out 14.093 APE11-dist-out 17.864 APE10-dist-out 20.978 APE9-dist-out 15.65 None None None EM 3.2 999.0 999.0 A 1409 1188 19 0 0 0 [[19, 321]] 1.0 9mhg OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 A0JP11_HUMAN 9ZPCA A0JP11 40 1358 1358.0 No_ligand No_ligand Inactive DFGin 9.774 16.571 BLBminus DFGAsp-rot-out -113.94, 147.12 53.86, 67.39 295.31, -29.91 -62.47, 111.94 290.25, 74.02 -107.23, 90.61 out-out out 18.294 Saltbr-out 19.413 HRD-in -74.98, -56.01 94.56, -17.32 out-out-out SNCooo out-out ActLoopNT-out 7.956 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.86, 32.29 APE9-dihe-na -85.18, -9.13 APE8-dihe-out 61.67, 20.06 APE8-rot-na 306.61 APE67-dihe-out -98.06, 128.02 -89.14, 104.18 APE12-dist-out 15.162 APE11-dist-out 19.538 APE10-dist-out 21.509 APE9-dist-out 15.793 None None None EM 3.83 999.0 999.0 A 1445 1045 66 0 0 0 [[19, 321]] 1.0 9zpc OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9C82A Q99570 64 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -164.16, -177.07 55.57, 42.13 999.0, 999.0 -52.45, 120.86 999.0, 999.0 -77.68, 59.73 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.24, -54.58 79.91, -42.88 none-out-out SNCnoo out-out ActLoopNT-out 8.339 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 78.23, -5.89 APE9-dihe-na -85.52, -1.85 APE8-dihe-out 57.79, 25.3 APE8-rot-none 999.0 APE67-dihe-out -115.98, 93.47 -52.79, 127.92 APE12-dist-out 15.521 APE11-dist-out 19.431 APE10-dist-out 22.667 APE9-dist-out 16.035 None None None EM 6.84 999.0 999.0 A 1358 1038 84 0 0 0 [[19, 321]] 1.0 9c82 OTHER_PIK3R4_HUMAN PIK3R4 6e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 7BL1CCC Q99570 12 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -76.88, 121.2 -97.88, -157.84 999.0, 999.0 -133.25, 23.54 999.0, 999.0 -119.58, 76.53 out-none out 19.336 Saltbr-none 999.0 HRD-out -62.71, 162.59 74.35, 11.28 none-out-out SNCnoo out-out ActLoopNT-out 17.743 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -137.26, 20.08 APE9-dihe-na -166.34, -173.1 APE8-dihe-out -69.07, -7.2 APE8-rot-none 999.0 APE67-dihe-out -53.52, 153.93 -148.29, -158.16 APE12-dist-out 15.718 APE11-dist-out 15.611 APE10-dist-out 15.777 APE9-dist-out 18.72 None None None EM 9.8 0.157 999.0 CCC 1371 1189 0 0 0 0 [[19, 321]] 1.0 7bl1 OTHER_PIK3R4_HUMAN PIK3R4 6.1e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHHA Q99570 16 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -128.48, 178.68 62.02, 54.05 999.0, 999.0 -67.58, 106.95 999.0, 999.0 -108.31, 61.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.85, -55.76 81.49, -5.71 none-out-out SNCnoo out-out ActLoopNT-out 9.548 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 57.34, 14.48 APE9-dihe-na -81.14, -9.46 APE8-dihe-out 59.93, 19.07 APE8-rot-none 999.0 APE67-dihe-out -125.77, 107.65 -89.25, 132.69 APE12-dist-out 15.001 APE11-dist-out 17.495 APE10-dist-out 20.139 APE9-dist-out 15.78 None None None EM 4.5 999.0 999.0 A 1409 1191 19 0 0 0 [[19, 321]] 1.0 9mhh OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PINK1 PINK1_HUMAN AF-Q9BXM7-K1A Q9BXM7 148 517 581.0 No_ligand No_ligand Active DFGin 9.586 14.505 BLAminus DFGAsp-rot-in -131.4, 170.11 65.48, 83.36 206.89, -32.07 -88.4, 10.85 283.16, 73.62 -63.31, -10.14 in-in in 7.718 Saltbr-in 2.772 HRD-in -71.34, -44.54 62.36, 0.39 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.93, -179.32 APE9-dihe-na -97.17, -38.44 APE8-dihe-in -93.22, 94.3 APE8-rot-na 193.02 APE67-dihe-in -74.22, -40.38 -58.35, -35.37 APE12-dist-in 7.595 APE11-dist-in 9.87 APE10-dist-in 5.376 APE9-dist-in 4.101 None None None AF2 -1.0 1.0 1.0 A 370 370 0 0 0 0 [[149, 517]] 1.0 AF-Q9BXM7-K1 OTHER_PINK1_HUMAN PINK1 2.6e-180 604.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN AF-Q9BXM7-K3A Q9BXM7 148 517 581.0 No_ligand No_ligand Active DFGin 9.682 14.874 BLAminus DFGAsp-rot-in -134.69, 177.63 63.96, 67.72 203.69, 19.82 -78.67, 7.51 279.74, 77.68 -57.02, -27.21 in-in in 7.761 Saltbr-in 2.727 HRD-in -71.41, -42.44 66.66, -21.06 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 67.28, 171.68 APE9-dihe-na 80.51, 178.42 APE8-dihe-in -80.68, 127.23 APE8-rot-na 174.28 APE67-dihe-in -69.6, -38.64 -57.25, -29.77 APE12-dist-in 8.45 APE11-dist-in 9.918 APE10-dist-in 5.312 APE9-dist-in 3.189 None None None AF2 -1.0 1.0 1.0 A 370 370 0 0 0 0 [[149, 517]] 1.0 AF-Q9BXM7-K3 OTHER_PINK1_HUMAN PINK1 2.6e-180 604.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIHA Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.866 15.327 BLAminus DFGAsp-rot-out -142.02, 178.57 55.72, 71.11 284.07, -37.37 -77.59, 9.12 276.87, 68.9 -55.56, -26.62 in-in in 8.303 Saltbr-in 2.884 HRD-out -78.93, 84.57 -67.64, 149.45 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_iiii APE10-dihe-na 114.17, 176.25 APE9-dihe-na -55.66, 130.94 APE8-dihe-out -76.94, 12.75 APE8-rot-na 300.82 APE67-dihe-out -63.75, -26.73 -62.57, 165.99 APE12-dist-in 8.275 APE11-dist-in 10.529 APE10-dist-in 5.942 APE9-dist-in 5.5 None None None EM 3.1 999.0 999.0 A 603 444 75 0 0 0 [[149, 517]] 1.0 9eih OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIHB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.642 15.29 None DFGAsp-rot-in -150.1, 27.9 -151.22, 84.19 199.09, 18.24 -78.07, 7.71 280.09, 73.93 -56.26, -25.65 in-in in 8.154 Saltbr-in 2.875 HRD-out -83.89, 74.38 -55.2, 147.76 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 129.6, 170.75 APE9-dihe-na -57.41, 126.81 APE8-dihe-in -63.88, 123.56 APE8-rot-na 292.08 APE67-dihe-out -68.62, -37.63 170.95, 170.71 APE12-dist-in 8.265 APE11-dist-in 10.701 APE10-dist-in 6.178 APE9-dist-in 5.511 None None None EM 3.1 999.0 999.0 B 603 443 76 0 0 0 [[149, 517]] 1.0 9eih OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIIB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.538 15.268 None DFGAsp-rot-in -148.12, 29.18 -150.34, 82.77 197.97, 16.56 -78.44, 7.18 280.06, 75.46 -55.89, -31.96 in-in in 8.191 Saltbr-in 2.699 HRD-out -84.11, 73.3 -54.72, 147.35 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.48, 169.31 APE9-dihe-na -55.3, 129.37 APE8-dihe-in -64.28, 120.54 APE8-rot-na 293.88 APE67-dihe-out -69.11, -35.23 177.3, 167.48 APE12-dist-in 8.425 APE11-dist-in 10.648 APE10-dist-in 6.093 APE9-dist-in 5.565 None None None EM 2.75 999.0 999.0 B 603 443 76 0 0 0 [[149, 517]] 1.0 9eii OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9EIJB Q9BXM7 63 581 581.0 No_ligand No_ligand Inactive DFGin 9.577 15.631 None DFGAsp-rot-in -148.4, 28.85 -150.95, 82.12 198.18, 16.61 -77.4, 7.45 279.57, 75.37 -55.31, -31.89 in-in in 8.335 Saltbr-in 3.173 HRD-out -83.93, 72.97 -54.61, 147.01 in-in-out SNCiio in-out ActLoopNT-in 2.775 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na 126.25, 168.92 APE9-dihe-na -55.5, 129.75 APE8-dihe-in -63.67, 120.0 APE8-rot-na 293.7 APE67-dihe-out -68.89, -34.96 176.76, 167.65 APE12-dist-in 8.27 APE11-dist-in 10.772 APE10-dist-in 6.249 APE9-dist-in 5.449 None None None EM 3.3 999.0 999.0 B 603 443 76 0 0 0 [[149, 517]] 1.0 9eij OTHER_PINK1_HUMAN PINK1 1.3e-179 602.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9KOXC Q9BXM7 156 581 581.0 No_ligand No_ligand Inactive None 59.112 58.651 None DFGAsp-rot-in -63.84, -40.63 54.61, 43.54 232.84, -59.43 -62.13, -40.37 32.7, 84.41 -64.27, 138.96 in-out in 8.248 Saltbr-out 5.022 HRD-out -128.7, 139.34 -72.53, -56.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.43 999.0 999.0 C 494 343 83 0 0 30 [[149, 517]] 1.0 9kox OTHER_PINK1_HUMAN PINK1 7.3e-180 603.6 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9KQNC Q9BXM7 305 581 581.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-in -160.89, 168.31 -118.27, 24.67 207.27, -7.67 -55.43, -33.65 98.75, 100.39 -89.11, 120.28 none-none none 999.0 Saltbr-none 999.0 HRD-out -88.71, 108.29 -61.88, -36.54 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 2.84 999.0 999.0 C 494 234 192 0 0 30 [[149, 517]] 1.0 9kqn OTHER_PINK1_HUMAN PINK1 7.3e-180 603.6 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN 9KMRC Q9BXM7 156 581 581.0 No_ligand No_ligand Inactive None 64.433 63.041 None DFGAsp-rot-out -162.72, 174.97 -139.57, 44.75 63.18, -22.52 -59.37, -28.03 81.51, 86.53 -93.46, 110.58 in-in in 7.715 Saltbr-in 2.453 HRD-out -77.53, 73.23 -61.65, -47.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 2.98 999.0 999.0 C 581 343 83 0 0 30 [[149, 517]] 1.0 9kmr OTHER_PINK1_HUMAN PINK1 1.2e-179 603.0 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PKDCC PKDCC_HUMAN AF-Q504Y2-K3A Q504Y2 130 399 493.0 No_ligand No_ligand Active DFGin 5.625 13.225 ABAminus DFGAsp-rot-in -115.52, -30.52 -109.0, 113.12 224.32, 10.3 -120.41, 2.25 291.97, 177.73 -63.94, -26.57 in-in in 7.813 Saltbr-in 2.639 HRD-na-N -98.36, 110.31 -73.96, -39.41 in-in-na SNCiia in-na ActLoopNT-in 2.801 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -95.48, -21.41 APE9-dihe-na -164.7, 177.58 APE8-dihe-na -59.61, -25.75 APE8-rot-na 330.23 APE67-dihe-na -85.52, -16.1 -63.32, -20.93 APE12-dist-na 19.69 APE11-dist-na 22.422 APE10-dist-na 26.816 APE9-dist-na 23.935 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[130, 399]] 1.0 AF-Q504Y2-K3 OTHER_PKDCC_HUMAN PKDCC 9.7e-128 431.0 1 270 270 294 295 296 298 300 166 199 203 275 277 276 278 339 316 311 310 309 308 307 306 305 234 Extracellular tyrosine-protein kinase PKDCC
OTHER PKDCC PKDCC_HUMAN AF-Q504Y2-K1A Q504Y2 130 399 493.0 No_ligand No_ligand Active DFGin 5.843 13.178 BLAminus DFGAsp-rot-in -130.23, 176.21 56.07, 54.42 210.57, 22.93 -79.83, 12.91 298.15, 177.88 -66.33, -28.17 in-in in 7.948 Saltbr-in 2.722 HRD-na-N -92.36, 99.32 -67.91, -32.86 in-in-na SNCiia in-na ActLoopNT-in 2.833 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -98.27, -24.58 APE9-dihe-na -160.57, 172.02 APE8-dihe-na -61.78, -18.01 APE8-rot-na 307.64 APE67-dihe-na -83.38, -14.59 -65.88, -19.96 APE12-dist-na 17.909 APE11-dist-na 20.99 APE10-dist-na 24.97 APE9-dist-na 23.019 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[130, 399]] 1.0 AF-Q504Y2-K1 OTHER_PKDCC_HUMAN PKDCC 9.7e-128 431.0 1 270 270 294 295 296 298 300 166 199 203 275 277 276 278 339 316 311 310 309 308 307 306 305 234 Extracellular tyrosine-protein kinase PKDCC
OTHER PKMYT1 PMYT1_HUMAN AF-Q99640-K1A Q99640 102 367 499.0 No_ligand No_ligand Inactive DFGin 6.42 13.937 BLAminus DFGAsp-rot-in -142.18, -168.0 57.83, 63.32 203.0, 15.5 -78.3, 23.73 306.23, 113.15 -65.54, -24.78 in-in in 8.716 Saltbr-in 2.674 HRD-in -78.23, -43.04 64.8, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.82, 139.71 APE9-dihe-na -79.9, -156.35 APE8-dihe-in -68.58, 121.44 APE8-rot-na 183.21 APE67-dihe-in -65.02, -28.9 -56.4, -24.44 APE12-dist-in 8.19 APE11-dist-out 5.909 APE10-dist-out 9.449 APE9-dist-in 3.898 None None None AF2 -1.0 1.0 1.0 A 266 266 0 0 0 0 [[110, 359]] 1.0 AF-Q99640-K1 OTHER_PKMYT1_HUMAN STE 5.8e-39 140.2 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN AF-Q99640-K3A Q99640 102 367 499.0 No_ligand No_ligand Active DFGin 6.236 13.701 BLAminus DFGAsp-rot-in -143.13, -168.07 58.28, 61.82 205.4, 10.13 -75.8, 25.38 307.25, 116.63 -66.88, -23.15 in-in in 8.561 Saltbr-in 2.634 HRD-in -79.61, -40.06 65.08, -14.15 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -115.86, 147.43 APE9-dihe-na 131.87, 175.12 APE8-dihe-in -90.14, 114.63 APE8-rot-na 184.92 APE67-dihe-in -64.0, -37.49 -58.22, -20.46 APE12-dist-in 8.015 APE11-dist-in 11.205 APE10-dist-in 6.6 APE9-dist-in 5.014 None None None AF2 -1.0 1.0 1.0 A 266 266 0 0 0 0 [[110, 359]] 1.0 AF-Q99640-K3 OTHER_PKMYT1_HUMAN STE 5.8e-39 140.2 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 3P1AA Q99640 76 362 499.0 No_ligand No_ligand Inactive DFGin 6.216 14.644 BLAminus DFGAsp-rot-out -133.67, -162.14 57.49, 68.87 286.05, -15.57 -85.75, 17.71 301.5, 112.21 -60.51, -27.31 in-in in 8.853 Saltbr-in 2.883 HRD-in -65.08, -43.54 71.41, -3.49 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooi APE10-dihe-na -94.27, 138.82 APE9-dihe-na -76.85, 177.99 APE8-dihe-in -60.09, 127.98 APE8-rot-na 184.73 APE67-dihe-in -58.71, -32.77 -62.35, -24.18 APE12-dist-out 6.772 APE11-dist-out 5.446 APE10-dist-out 8.988 APE9-dist-in 3.515 None None None XRAY 1.7 0.152 0.195 A 311 281 6 0 0 6 [[110, 359]] 1.0 3p1a OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8ZTXA Q99640 75 361 499.0 A1D83:401 Type1 Inactive DFGin 6.445 14.436 BLAminus DFGAsp-rot-in -137.85, -159.22 59.85, 66.88 191.24, 31.33 -90.63, 11.4 293.03, 126.73 -73.26, -10.59 in-in in 9.068 Saltbr-in 2.83 HRD-out -87.92, 121.21 -96.15, 14.43 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooi APE10-dihe-na -73.57, 129.4 APE9-dihe-na -75.5, 167.07 APE8-dihe-in -68.16, 128.19 APE8-rot-na 189.14 APE67-dihe-in -58.79, -32.8 -64.52, -23.06 APE12-dist-out 5.34 APE11-dist-out 6.439 APE10-dist-out 9.664 APE9-dist-in 3.651 None None None XRAY 1.7 0.183 0.216 A 288 276 4 0 0 3 [[110, 359]] 1.0 8ztx OTHER_PKMYT1_HUMAN STE 7.8e-39 139.7 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGVB Q99640 77 361 499.0 A1EJV:403 Type1 Inactive DFGin 6.358 14.519 BLAminus DFGAsp-rot-out -139.58, -160.2 51.05, 71.76 290.25, -14.66 -89.99, 26.16 301.47, 116.48 -66.83, -24.64 in-in in 8.844 Saltbr-in 2.746 HRD-in -67.6, -49.72 69.87, 5.57 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -66.13, 126.77 APE9-dihe-na -93.12, 179.57 APE8-dihe-in -80.66, 111.84 APE8-rot-na 194.83 APE67-dihe-in -61.91, -33.86 -60.46, -22.61 APE12-dist-in 8.039 APE11-dist-out 5.587 APE10-dist-out 9.595 APE9-dist-in 4.725 None None None XRAY 2.041 0.194 0.234 B 288 279 6 0 0 6 [[110, 359]] 1.0 9lgv OTHER_PKMYT1_HUMAN STE 7.8e-39 139.7 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8ZU2A Q99640 75 361 499.0 A1D85:502 Type1 Inactive DFGin 6.426 14.164 BLAminus DFGAsp-rot-in -143.18, -161.94 58.06, 72.03 197.87, 9.29 -94.83, 14.01 296.25, 122.75 -74.58, -10.24 in-in in 9.031 Saltbr-in 2.807 HRD-out -88.49, 117.25 -97.58, 15.79 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooi APE10-dihe-na -77.33, 131.47 APE9-dihe-na -75.94, 168.29 APE8-dihe-in -67.63, 125.44 APE8-rot-na 189.07 APE67-dihe-in -58.12, -32.81 -63.45, -25.22 APE12-dist-out 5.373 APE11-dist-out 6.476 APE10-dist-out 9.654 APE9-dist-in 3.587 None None None XRAY 1.799 0.181 0.222 A 287 273 7 0 0 5 [[110, 359]] 1.0 8zu2 OTHER_PKMYT1_HUMAN STE 7.7e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8ZUDA Q99640 75 361 499.0 A1D82:401 Type1 Inactive DFGin 6.321 14.353 BLAminus DFGAsp-rot-in -140.04, -162.56 63.44, 68.43 194.09, 31.23 -90.94, 13.24 294.38, 121.99 -65.79, -18.98 in-in in 9.069 Saltbr-in 2.789 HRD-out -84.37, 118.24 -94.57, 15.46 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooi APE10-dihe-na -73.12, 115.52 APE9-dihe-na -67.77, 166.87 APE8-dihe-in -72.47, 122.64 APE8-rot-na 187.82 APE67-dihe-in -58.53, -33.84 -61.09, -24.42 APE12-dist-out 5.036 APE11-dist-out 6.204 APE10-dist-out 9.679 APE9-dist-in 3.923 None None None XRAY 1.505 0.204 0.238 A 287 280 4 0 0 3 [[110, 359]] 1.0 8zud OTHER_PKMYT1_HUMAN STE 7.7e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8ZULA Q99640 75 361 499.0 A1D84:401 Type1 Inactive DFGin 6.412 14.179 BLAminus DFGAsp-rot-in -138.34, -163.13 57.44, 78.97 200.48, -22.67 -95.66, 20.39 298.61, 119.83 -65.91, -22.49 in-in in 9.119 Saltbr-in 2.878 HRD-out -86.65, 118.04 -96.94, 17.18 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooi APE10-dihe-na -86.92, 115.88 APE9-dihe-na -65.84, 161.03 APE8-dihe-in -64.68, 125.13 APE8-rot-na 189.07 APE67-dihe-in -58.22, -33.63 -66.01, -22.62 APE12-dist-out 5.224 APE11-dist-out 6.317 APE10-dist-out 9.704 APE9-dist-in 3.797 None None None XRAY 1.8 0.188 0.219 A 287 278 4 0 0 3 [[110, 359]] 1.0 8zul OTHER_PKMYT1_HUMAN STE 7.7e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGLA Q99640 78 361 499.0 A1EJW:401 Type1 Inactive DFGin 6.071 14.461 BLAminus DFGAsp-rot-in -136.52, -168.54 55.02, 82.28 198.01, -5.4 -98.77, 26.36 303.21, 105.93 -68.53, -22.91 in-in in 9.07 Saltbr-in 2.774 HRD-in -72.0, -47.88 68.59, 9.6 in-in-out SNCiio in-out ActLoopNT-in 2.973 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -72.07, 123.35 APE9-dihe-na -90.71, 177.99 APE8-dihe-in -76.33, 121.78 APE8-rot-na 199.0 APE67-dihe-in -62.44, -32.83 -69.35, -22.28 APE12-dist-in 7.552 APE11-dist-out 6.056 APE10-dist-out 9.809 APE9-dist-in 4.604 None None None XRAY 2.17 0.199 0.234 A 287 269 7 0 0 7 [[110, 359]] 1.0 9lgl OTHER_PKMYT1_HUMAN STE 7.7e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGLB Q99640 75 361 499.0 A1EJW:602 Type1 Inactive DFGin 6.19 14.659 BLAminus DFGAsp-rot-in -138.78, -167.73 53.99, 80.56 198.76, -6.29 -97.13, 31.13 301.33, 106.64 -70.92, -24.39 in-in in 8.979 Saltbr-in 2.604 HRD-in -71.57, -47.46 69.81, 5.38 in-in-out SNCiio in-out ActLoopNT-in 2.937 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -71.5, 123.2 APE9-dihe-na -90.52, 177.91 APE8-dihe-in -75.73, 120.5 APE8-rot-na 196.52 APE67-dihe-in -66.74, -28.94 -66.51, -21.84 APE12-dist-in 7.779 APE11-dist-out 5.745 APE10-dist-out 9.557 APE9-dist-in 4.476 None None None XRAY 2.17 0.199 0.234 B 287 276 3 0 0 3 [[110, 359]] 1.0 9lgl OTHER_PKMYT1_HUMAN STE 7.7e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCVA Q99640 75 361 499.0 1N1:60404 Type1 Inactive DFGin 6.173 14.468 BLAminus DFGAsp-rot-out -133.17, -164.16 53.7, 76.36 271.84, 58.09 -96.77, 22.58 298.04, 107.44 -64.77, -25.22 in-in in 8.918 Saltbr-in 2.826 HRD-in -73.66, -44.65 68.1, -0.34 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -65.91, 159.0 APE9-dihe-na -91.66, -157.73 APE8-dihe-in -52.29, 123.12 APE8-rot-na 188.83 APE67-dihe-in -60.44, -30.04 -60.97, -24.44 APE12-dist-in 7.945 APE11-dist-out 6.449 APE10-dist-out 9.08 APE9-dist-in 3.179 None TPO260 TPO260 XRAY 1.92 0.157 0.197 A 311 287 0 0 0 0 [[110, 359]] 1.0 5vcv OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCWA Q99640 77 361 499.0 93J:401 Type1 Inactive DFGin 5.753 14.403 BLAminus DFGAsp-rot-in -140.89, -170.02 65.17, 65.71 195.7, -12.43 -80.17, 44.69 310.3, 111.94 -72.85, -37.75 in-in in 8.674 Saltbr-in 2.692 HRD-in -65.93, -47.94 69.86, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -70.16, 136.95 APE9-dihe-na -95.11, -179.89 APE8-dihe-in -74.56, 119.43 APE8-rot-na 190.69 APE67-dihe-in -62.5, -29.66 -60.78, -22.9 APE12-dist-in 7.636 APE11-dist-out 5.401 APE10-dist-out 9.233 APE9-dist-in 4.514 None None None XRAY 2.25 0.196 0.246 A 311 285 0 0 0 0 [[110, 359]] 1.0 5vcw OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCWB Q99640 77 361 499.0 93J:401 Type1 Inactive DFGin 6.174 14.753 BLAminus DFGAsp-rot-in -145.87, -171.97 60.37, 74.58 201.14, -10.39 -84.49, 28.86 300.8, 108.65 -60.24, -45.91 in-out in 8.991 Saltbr-out 3.796 HRD-in -67.52, -46.64 69.7, -6.0 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -83.37, 139.87 APE9-dihe-na -94.4, -171.94 APE8-dihe-in -64.72, 123.4 APE8-rot-na 193.82 APE67-dihe-in -58.05, -32.99 -66.08, -23.26 APE12-dist-in 8.122 APE11-dist-out 5.498 APE10-dist-out 9.225 APE9-dist-in 4.375 None None None XRAY 2.25 0.196 0.246 B 311 285 0 0 0 0 [[110, 359]] 1.0 5vcw OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCXA Q99640 75 361 499.0 H8H:401 Type1 Inactive DFGin 5.945 14.566 BLAminus DFGAsp-rot-in -133.1, -159.74 56.06, 76.15 200.88, 18.36 -98.03, 28.4 300.17, 108.44 -60.31, -33.85 in-in in 8.996 Saltbr-in 3.063 HRD-in -70.1, -45.94 70.27, -2.25 in-in-out SNCiio in-out ActLoopNT-in 3.051 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -72.13, 165.11 APE9-dihe-na -95.53, -151.65 APE8-dihe-in -59.58, 124.62 APE8-rot-na 194.34 APE67-dihe-in -61.23, -27.43 -59.74, -28.49 APE12-dist-in 7.851 APE11-dist-out 6.313 APE10-dist-out 9.373 APE9-dist-in 3.304 None None None XRAY 2.7 0.201 0.244 A 311 287 0 0 0 0 [[110, 359]] 1.0 5vcx OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCYA Q99640 77 362 499.0 DB8:60401 Type1 Inactive DFGin 5.969 14.359 BLAminus DFGAsp-rot-in -127.91, -168.29 70.38, 72.35 195.88, 18.47 -96.64, 23.14 300.41, 119.28 -68.58, -24.5 in-in in 8.714 Saltbr-in 2.719 HRD-in -69.32, -46.71 70.97, 0.9 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -97.27, 135.17 APE9-dihe-na -76.61, -179.9 APE8-dihe-in -57.88, 126.16 APE8-rot-na 189.14 APE67-dihe-in -62.75, -28.84 -62.08, -23.7 APE12-dist-in 8.015 APE11-dist-out 5.197 APE10-dist-out 9.02 APE9-dist-in 3.47 None None None XRAY 1.56 0.14 0.178 A 311 286 0 0 0 0 [[110, 359]] 1.0 5vcy OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VCZA Q99640 78 361 499.0 XZN:60401 Type1 Inactive DFGin 6.225 14.363 BLAminus DFGAsp-rot-in -132.39, -165.29 58.87, 84.05 200.02, -23.25 -99.27, 22.38 300.75, 125.52 -66.24, -24.02 in-in in 8.752 Saltbr-in 2.82 HRD-in -66.5, -47.19 72.05, -1.84 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -98.79, 140.56 APE9-dihe-na -80.46, -177.58 APE8-dihe-in -60.96, 126.51 APE8-rot-na 185.51 APE67-dihe-in -59.29, -30.37 -61.35, -26.02 APE12-dist-in 8.031 APE11-dist-out 5.671 APE10-dist-out 9.053 APE9-dist-in 3.572 None None None XRAY 1.5 0.148 0.181 A 311 284 0 0 0 0 [[110, 359]] 1.0 5vcz OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VD0A Q99640 77 361 499.0 8X7:60401 Type1 Inactive DFGin 5.962 14.355 BLAminus DFGAsp-rot-in -141.72, -158.67 59.97, 64.91 192.22, 28.18 -92.35, 27.87 296.04, 115.37 -71.23, -25.83 in-in in 8.585 Saltbr-in 2.96 HRD-in -71.7, -46.16 66.6, 10.57 in-in-out SNCiio in-out ActLoopNT-in 2.798 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -105.71, 140.12 APE9-dihe-na -72.16, -168.22 APE8-dihe-in -65.78, 129.44 APE8-rot-na 186.07 APE67-dihe-in -65.63, -30.01 -61.48, -23.1 APE12-dist-in 7.891 APE11-dist-out 6.337 APE10-dist-out 9.159 APE9-dist-in 3.413 None None None XRAY 2.13 0.195 0.231 A 311 285 0 0 0 0 [[110, 359]] 1.0 5vd0 OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VD1A Q99640 77 361 499.0 P48:60401 Type1 Inactive DFGin 5.996 14.265 BLAminus DFGAsp-rot-in -132.04, -170.59 60.28, 78.86 193.08, -8.15 -90.66, 20.44 292.47, 159.81 -62.59, -30.61 in-in in 8.633 Saltbr-in 2.718 HRD-in -67.73, -45.78 69.79, 0.1 in-in-out SNCiio in-out ActLoopNT-in 2.858 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -100.09, 132.84 APE9-dihe-na -80.03, -175.61 APE8-dihe-in -61.66, 124.95 APE8-rot-na 190.14 APE67-dihe-in -61.12, -28.84 -63.37, -24.36 APE12-dist-in 10.437 APE11-dist-out 4.987 APE10-dist-out 9.009 APE9-dist-in 3.507 None None None XRAY 1.7 0.146 0.194 A 311 285 0 0 0 0 [[110, 359]] 1.0 5vd1 OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 5VD3A Q99640 78 360 499.0 H8H:60401 Type1 Inactive DFGin 5.988 14.425 BLAminus DFGAsp-rot-in -136.31, -163.22 68.56, 66.31 197.45, 22.84 -95.1, 21.81 295.33, 125.87 -68.4, -23.33 in-in in 8.495 Saltbr-in 2.673 HRD-in -69.52, -49.09 74.0, 4.67 in-in-out SNCiio in-out ActLoopNT-in 2.908 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -97.34, 136.82 APE9-dihe-na -76.5, -172.94 APE8-dihe-in -60.8, 125.68 APE8-rot-na 188.67 APE67-dihe-in -61.07, -31.05 -63.33, -22.08 APE12-dist-in 7.69 APE11-dist-out 5.948 APE10-dist-out 9.338 APE9-dist-in 3.59 None None None XRAY 1.8 0.167 0.204 A 311 283 0 0 0 0 [[110, 359]] 1.0 5vd3 OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6CA Q99640 78 362 499.0 QGR:404 Type1 Inactive DFGin 6.172 14.665 BLAminus DFGAsp-rot-in -138.72, -172.18 56.12, 81.66 196.01, -2.63 -98.6, 28.37 305.05, 105.89 -67.69, -35.68 in-in in 9.223 Saltbr-in 2.867 HRD-in -68.86, -47.17 68.84, 2.61 in-in-out SNCiio in-out ActLoopNT-in 3.043 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.71, 138.8 APE9-dihe-na -112.82, 177.1 APE8-dihe-in -70.21, 118.66 APE8-rot-na 199.55 APE67-dihe-in -65.27, -28.23 -67.62, -21.84 APE12-dist-in 7.994 APE11-dist-out 5.138 APE10-dist-out 9.147 APE9-dist-in 4.417 None None None XRAY 2.2 0.243 0.267 A 311 276 4 0 0 4 [[110, 359]] 1.0 8d6c OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6CB Q99640 77 360 499.0 QGR:405 Type1 Inactive DFGin 6.108 14.617 BLAminus DFGAsp-rot-in -137.16, -171.57 55.86, 81.51 196.43, -1.79 -98.43, 27.78 304.23, 105.4 -67.24, -36.0 in-in in 9.1 Saltbr-in 2.634 HRD-in -69.35, -47.2 69.11, 3.07 in-in-out SNCiio in-out ActLoopNT-in 2.993 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.45, 139.33 APE9-dihe-na -113.05, 178.09 APE8-dihe-in -69.89, 119.27 APE8-rot-na 200.33 APE67-dihe-in -65.97, -28.13 -67.77, -22.03 APE12-dist-in 7.79 APE11-dist-out 5.408 APE10-dist-out 9.568 APE9-dist-in 4.624 None None None XRAY 2.2 0.243 0.267 B 311 279 3 0 0 3 [[110, 359]] 1.0 8d6c OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6DB Q99640 77 361 499.0 QGY:404 Type1 Inactive DFGin 6.147 14.603 BLAminus DFGAsp-rot-in -147.14, -174.0 60.06, 69.22 192.54, 5.6 -88.07, 31.47 303.72, 105.86 -72.48, -40.72 in-in in 8.999 Saltbr-in 2.772 HRD-in -71.49, -51.39 74.57, -2.28 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -86.53, 143.01 APE9-dihe-na -115.07, 178.0 APE8-dihe-in -63.78, 124.17 APE8-rot-na 190.84 APE67-dihe-in -58.21, -31.84 -62.0, -28.89 APE12-dist-in 8.114 APE11-dist-out 5.203 APE10-dist-out 9.25 APE9-dist-in 4.199 None None None XRAY 2.35 0.242 0.272 B 311 274 6 0 0 6 [[110, 359]] 1.0 8d6d OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6EB Q99640 77 361 499.0 QGI:402 Type1 Inactive DFGin 6.114 14.465 BLAminus DFGAsp-rot-in -132.8, -171.53 58.57, 80.76 198.06, -3.81 -95.11, 24.5 304.2, 110.2 -64.56, -30.79 in-in in 8.951 Saltbr-in 2.628 HRD-in -73.41, -48.43 71.29, 4.33 in-in-out SNCiio in-out ActLoopNT-in 2.998 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -71.04, 132.61 APE9-dihe-na -98.92, -179.59 APE8-dihe-in -79.2, 116.58 APE8-rot-na 195.17 APE67-dihe-in -57.38, -35.46 -62.14, -27.07 APE12-dist-in 7.932 APE11-dist-out 5.296 APE10-dist-out 9.4 APE9-dist-in 4.697 None None None XRAY 2.15 0.192 0.218 B 311 281 0 0 0 0 [[110, 359]] 1.0 8d6e OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8WJYA Q99640 76 361 499.0 W9X:60401 Type1 Inactive DFGin 5.935 14.221 BLAminus DFGAsp-rot-in -135.65, -170.95 60.01, 76.07 191.98, -0.87 -89.46, 18.35 301.57, 113.76 -59.15, -32.82 in-in in 8.832 Saltbr-in 2.806 HRD-in -66.07, -46.85 67.06, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nooi APE10-dihe-na -114.14, 142.3 APE9-dihe-na -71.54, 178.2 APE8-dihe-in -61.77, 125.41 APE8-rot-na 182.9 APE67-dihe-in -64.92, -26.73 -59.54, -24.39 APE12-dist-none 999.0 APE11-dist-out 5.785 APE10-dist-out 8.923 APE9-dist-in 3.225 None None None XRAY 1.88 0.174 0.217 A 311 281 5 0 0 5 [[110, 359]] 1.0 8wjy OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9M6PAAA Q99640 78 361 499.0 A1EMX:401 Type1 Inactive DFGin 5.882 14.502 BLAminus DFGAsp-rot-in -134.53, -168.45 48.74, 78.92 199.28, -1.64 -95.7, 22.92 299.91, 114.53 -64.04, -30.22 in-in in 8.791 Saltbr-in 2.932 HRD-in -72.24, -50.49 83.32, -3.18 in-in-out SNCiio in-out ActLoopNT-in 2.896 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 174.25 APE9-dihe-na -61.97, 170.52 APE8-dihe-in -68.14, 121.24 APE8-rot-na 192.46 APE67-dihe-in -58.03, -44.1 -54.7, -32.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.286 APE9-dist-in 3.496 None None None XRAY 2.383 0.207 0.29 AAA 311 274 7 0 0 7 [[110, 359]] 1.0 9m6p OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGVA Q99640 77 361 499.0 A1EJV:403 Type1.5_Back Inactive DFGin 6.247 14.441 BLAminus DFGAsp-rot-out -138.6, -160.29 51.54, 71.26 289.17, -16.82 -89.36, 26.39 302.35, 116.07 -67.62, -25.64 in-in in 8.813 Saltbr-in 2.72 HRD-in -66.78, -49.09 69.76, 4.94 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -64.33, 125.9 APE9-dihe-na -92.9, 178.41 APE8-dihe-in -82.16, 111.58 APE8-rot-na 195.81 APE67-dihe-in -61.81, -34.11 -61.17, -22.76 APE12-dist-in 7.729 APE11-dist-out 5.577 APE10-dist-out 9.531 APE9-dist-in 4.737 None None None XRAY 2.041 0.194 0.234 A 288 277 7 0 0 7 [[110, 359]] 1.0 9lgv OTHER_PKMYT1_HUMAN STE 7.8e-39 139.7 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LIDA Q99640 77 361 499.0 A1EJX:401 Type1.5_Back Inactive DFGin 6.147 14.664 BLAminus DFGAsp-rot-in -141.57, -159.93 44.66, 82.65 203.67, -24.25 -96.79, 25.45 296.42, 128.92 -69.09, -25.86 in-in in 8.914 Saltbr-in 2.78 HRD-in -71.98, -50.6 73.9, 10.26 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -65.91, 118.73 APE9-dihe-na -84.87, 178.55 APE8-dihe-in -75.21, 121.23 APE8-rot-na 199.89 APE67-dihe-in -56.46, -34.28 -66.08, -29.38 APE12-dist-in 7.934 APE11-dist-out 5.555 APE10-dist-out 9.424 APE9-dist-in 4.289 None None None XRAY 2.06 0.205 0.231 A 288 272 5 0 0 5 [[110, 359]] 1.0 9lid OTHER_PKMYT1_HUMAN STE 7.8e-39 139.7 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LIDB Q99640 77 361 499.0 A1EJX:401 Type1.5_Back Inactive DFGin 6.109 14.623 BLAminus DFGAsp-rot-in -138.92, -162.74 50.8, 79.94 195.99, -8.48 -95.85, 31.4 299.01, 122.08 -70.56, -35.67 in-in in 8.837 Saltbr-in 2.739 HRD-in -63.43, -48.29 66.83, 6.87 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -70.06, 130.49 APE9-dihe-na -98.3, 177.7 APE8-dihe-in -71.64, 117.04 APE8-rot-na 198.93 APE67-dihe-in -59.05, -34.81 -63.57, -26.6 APE12-dist-in 7.886 APE11-dist-out 5.525 APE10-dist-out 9.483 APE9-dist-in 4.637 None None None XRAY 2.06 0.205 0.231 B 288 279 0 0 0 0 [[110, 359]] 1.0 9lid OTHER_PKMYT1_HUMAN STE 7.8e-39 139.7 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGNA Q99640 77 361 499.0 A1EJU:60401 Type1.5_Back Inactive DFGin 6.296 14.466 BLAminus DFGAsp-rot-in -145.99, -171.4 50.86, 84.26 201.0, -30.94 -97.86, 29.36 304.36, 111.52 -72.91, -21.87 in-in in 8.887 Saltbr-in 2.795 HRD-in -66.21, -46.68 65.26, 16.91 in-in-out SNCiio in-out ActLoopNT-in 3.082 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.54, 120.07 APE9-dihe-na -90.78, -176.48 APE8-dihe-in -82.34, 121.43 APE8-rot-na 199.89 APE67-dihe-in -63.02, -34.9 -65.92, -23.54 APE12-dist-in 7.833 APE11-dist-out 5.486 APE10-dist-out 9.422 APE9-dist-in 4.545 None None None XRAY 2.03 0.196 0.241 A 286 280 5 0 0 5 [[110, 359]] 1.0 9lgn OTHER_PKMYT1_HUMAN STE 7.6e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9LGNB Q99640 77 361 499.0 A1EJU:60401 Type1.5_Back Inactive DFGin 6.068 14.404 BLAminus DFGAsp-rot-in -142.39, -165.96 54.01, 79.86 198.68, -7.57 -92.24, 28.67 300.8, 134.57 -69.88, -31.54 in-in in 8.842 Saltbr-in 2.621 HRD-in -68.45, -46.04 66.53, 9.81 in-in-out SNCiio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -64.59, 124.38 APE9-dihe-na -93.34, -179.18 APE8-dihe-in -77.16, 120.0 APE8-rot-na 200.38 APE67-dihe-in -63.03, -36.01 -66.03, -24.01 APE12-dist-in 7.864 APE11-dist-out 5.611 APE10-dist-out 9.357 APE9-dist-in 4.519 None None None XRAY 2.03 0.196 0.241 B 286 281 4 0 0 4 [[110, 359]] 1.0 9lgn OTHER_PKMYT1_HUMAN STE 7.6e-39 139.8 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6DA Q99640 78 361 499.0 QGY:405 Type1.5_Back Inactive DFGin 6.211 14.538 BLAminus DFGAsp-rot-in -148.07, -173.76 61.71, 69.04 194.6, 4.39 -87.4, 33.63 306.09, 107.4 -73.23, -43.69 in-in in 8.979 Saltbr-in 2.792 HRD-in -70.41, -52.13 74.56, -0.66 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -82.14, 144.34 APE9-dihe-na -114.82, 178.25 APE8-dihe-in -66.9, 123.15 APE8-rot-na 195.13 APE67-dihe-in -58.55, -32.2 -61.02, -29.72 APE12-dist-in 7.901 APE11-dist-out 5.216 APE10-dist-out 9.078 APE9-dist-in 4.364 None None None XRAY 2.35 0.242 0.272 A 311 270 5 0 0 5 [[110, 359]] 1.0 8d6d OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6EA Q99640 77 361 499.0 QGI:1303 Type1.5_Back Inactive DFGin 5.964 14.172 BLAminus DFGAsp-rot-in -132.85, -170.23 57.02, 82.01 197.8, -3.86 -94.72, 23.46 304.19, 110.84 -65.02, -29.08 in-in in 8.87 Saltbr-in 2.717 HRD-in -75.21, -49.23 71.68, 5.95 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -70.02, 134.68 APE9-dihe-na -98.58, -177.84 APE8-dihe-in -78.94, 114.38 APE8-rot-na 196.53 APE67-dihe-in -55.24, -36.47 -61.38, -25.28 APE12-dist-in 7.804 APE11-dist-out 5.579 APE10-dist-out 9.69 APE9-dist-in 4.697 None None None XRAY 2.15 0.192 0.218 A 311 278 3 0 0 3 [[110, 359]] 1.0 8d6e OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6FA Q99640 78 361 499.0 QG5:402 Type1.5_Back Inactive DFGin 5.934 14.393 BLAminus DFGAsp-rot-in -137.99, -170.0 54.51, 81.69 199.34, -7.26 -95.67, 27.93 303.43, 112.84 -67.3, -27.64 in-in in 8.927 Saltbr-in 2.693 HRD-in -64.05, -49.24 70.41, 3.13 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -70.94, 136.66 APE9-dihe-na -111.83, 176.77 APE8-dihe-in -71.13, 118.43 APE8-rot-na 201.17 APE67-dihe-in -57.59, -30.74 -64.31, -29.06 APE12-dist-in 7.268 APE11-dist-out 5.262 APE10-dist-out 9.373 APE9-dist-in 4.633 None None None XRAY 2.49 0.216 0.239 A 311 270 6 0 0 6 [[110, 359]] 1.0 8d6f OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 8D6FB Q99640 76 361 499.0 QG5:402 Type1.5_Back Inactive DFGin 6.014 14.327 BLAminus DFGAsp-rot-in -137.52, -169.84 54.56, 81.42 198.91, -7.15 -96.27, 27.52 303.69, 112.72 -67.62, -27.32 in-in in 8.86 Saltbr-in 2.731 HRD-in -63.86, -48.97 70.29, 4.03 in-in-out SNCiio in-out ActLoopNT-in 3.061 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -70.91, 136.32 APE9-dihe-na -112.58, 175.93 APE8-dihe-in -71.78, 118.97 APE8-rot-na 200.9 APE67-dihe-in -57.56, -31.19 -64.02, -28.04 APE12-dist-in 7.294 APE11-dist-out 5.136 APE10-dist-out 9.236 APE9-dist-in 4.543 None None None XRAY 2.49 0.216 0.239 B 311 272 6 0 0 6 [[110, 359]] 1.0 8d6f OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PKMYT1 PMYT1_HUMAN 9M6PBBB Q99640 78 361 499.0 A1EMX:401 Type1.5_Back Active DFGin 5.669 14.666 BLAminus DFGAsp-rot-in -131.55, -170.33 48.66, 72.13 209.14, -30.46 -83.6, 27.49 299.21, 115.57 -58.85, -40.14 in-in in 9.083 Saltbr-in 2.939 HRD-in -81.31, -52.85 67.1, 16.58 in-in-in SNCiii in-in ActLoopNT-in 2.689 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -92.01, 34.89 APE9-dihe-na -82.85, 167.58 APE8-dihe-in -98.1, 112.26 APE8-rot-na 199.29 APE67-dihe-in -67.7, -28.82 -66.94, -18.17 APE12-dist-in 8.01 APE11-dist-in 10.161 APE10-dist-in 7.317 APE9-dist-in 4.909 None None None XRAY 2.383 0.207 0.29 BBB 311 284 0 0 0 0 [[110, 359]] 1.0 9m6p OTHER_PKMYT1_HUMAN STE 1e-38 139.4 1 255 255 250 251 252 254 256 139 157 161 230 232 231 233 288 277 272 271 270 269 268 267 266 188 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
OTHER PRAG1 PRAG1_HUMAN 5VE6A Q86YV5 944 1405 1406.0 No_ligand No_ligand Pseudo None 999.0 15.913 None DFGAsp-rot-out -72.21, 156.31 -91.78, 163.14 301.96, -30.06 -113.76, 999.0 51.93, 89.28 999.0, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.41, 103.68 -60.03, -25.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.953 0.222 0.262 A 492 348 95 0 0 21 [[984, 1335]] 1.0 5ve6 OTHER_PRAG1_HUMAN PEAK 1.1e-148 503.5 1 349 349 1215 1216 1217 1219 1221 1024 1034 1038 1142 1144 1143 1145 1253 1242 1237 1236 1235 1234 1233 1232 1231 1093 Inactive tyrosine-protein kinase PRAG1
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.529 12.379 BLAminus DFGAsp-rot-in -152.72, -178.03 59.98, 103.61 179.03, 8.9 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.993 Saltbr-in 2.623 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.068 APE11-dist-na 16.875 APE10-dist-na 14.985 APE9-dist-na 14.333 H672N None None XRAY 2.6 0.213 0.251 C 699 692 0 0 0 0 [[353, 594]] 1.0 4oau OTHER_RNASEL_HUMAN RNASEL 4.2e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVB Q05823 24 717 741.0 ACP:801 ATPlike Pseudo DFGin 6.475 12.367 BLAminus DFGAsp-rot-in -139.92, -178.5 65.74, 91.26 187.38, 6.91 -114.98, 14.68 309.18, 101.1 -77.21, 3.69 in-in in 6.905 Saltbr-in 2.74 HRD-in -87.38, -45.25 69.13, -2.14 in-in-na SNCiia in-na ActLoopNT-in 3.06 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.56, 102.63 APE9-dihe-na -56.52, -19.13 APE8-dihe-na -66.25, -31.04 APE8-rot-na 198.81 APE67-dihe-na -66.21, -44.37 -71.69, -39.0 APE12-dist-na 15.293 APE11-dist-na 17.012 APE10-dist-na 15.02 APE9-dist-na 14.396 H672N None None XRAY 2.1 0.2 0.229 B 699 673 8 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.2e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER RNASEL RN5A_HUMAN 4OAVD Q05823 26 719 741.0 ACP:1001 ATPlike Pseudo DFGin 6.559 12.405 BLAminus DFGAsp-rot-in -138.71, -178.08 64.72, 95.25 186.41, 9.8 -118.8, 14.99 306.98, 96.56 -77.32, 4.45 in-in in 6.904 Saltbr-in 2.919 HRD-in -73.82, -49.38 73.22, -2.68 in-in-na SNCiia in-na ActLoopNT-in 2.915 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.59, 112.49 APE9-dihe-na -62.01, -29.18 APE8-dihe-na -62.89, -32.55 APE8-rot-na 188.49 APE67-dihe-na -70.07, -38.9 -67.42, -39.34 APE12-dist-na 14.651 APE11-dist-na 16.869 APE10-dist-na 14.635 APE9-dist-na 14.352 H672N None None XRAY 2.1 0.2 0.229 D 699 674 7 0 0 0 [[353, 594]] 1.0 4oav OTHER_RNASEL_HUMAN RNASEL 4.2e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
OTHER SBK1 SBK1_HUMAN AF-Q52WX2-K1A Q52WX2 45 323 424.0 No_ligand No_ligand Active DFGin 5.418 14.068 BLAminus DFGAsp-rot-in -137.64, 177.99 62.46, 73.42 199.64, 17.65 -87.96, 15.35 297.93, 88.83 -58.2, -31.11 in-in in 8.97 Saltbr-in 2.704 HRD-in -67.69, -50.46 68.6, 8.96 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.82, 145.65 APE9-dihe-na 117.58, 179.89 APE8-dihe-in -88.3, 116.54 APE8-rot-in 309.21 APE67-dihe-in -59.27, -31.59 -50.4, -47.0 APE12-dist-in 11.466 APE11-dist-in 12.496 APE10-dist-in 6.89 APE9-dist-in 4.202 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[53, 315]] 1.0 AF-Q52WX2-K1 OTHER_SBK1_HUMAN CAMK 2.4e-49 174.0 1 251 251 193 194 195 197 199 82 97 101 171 173 172 174 235 218 213 212 211 210 209 208 207 129 Serine/threonine-protein kinase SBK1
OTHER SBK1 SBK1_HUMAN AF-Q52WX2-K3A Q52WX2 45 323 424.0 No_ligand No_ligand Active DFGin 5.374 14.499 BLAminus DFGAsp-rot-in -134.4457, -177.5185 62.8991, 55.9001 204.9808, 10.0492 -75.6368, 6.8084 294.5554, 85.7366 -60.6609, -25.6249 in-in in 8.159 Saltbr-in 2.679 HRD-in -67.1042, -51.4959 68.7382, 16.4978 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.4679, 149.9328 APE9-dihe-na 108.0845, 170.5782 APE8-dihe-in -82.9304, 114.5756 APE8-rot-in 306.7241 APE67-dihe-in -54.8002, -28.7282 -49.5901, -45.6233 APE12-dist-in 11.428 APE11-dist-in 12.566 APE10-dist-in 7.126 APE9-dist-in 3.618 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[53, 315]] 1.0 AF-Q52WX2-K3 OTHER_SBK1_HUMAN CAMK 2.4e-49 174.0 1 251 251 193 194 195 197 199 82 97 101 171 173 172 174 235 218 213 212 211 210 209 208 207 129 Serine/threonine-protein kinase SBK1
OTHER SBK2 SBK2_HUMAN AF-P0C263-K1A P0C263 54 335 348.0 No_ligand No_ligand Inactive DFGin 5.386 12.967 BLAminus DFGAsp-rot-in -121.38, -169.04 47.35, 87.88 204.55, -5.09 -96.82, 14.68 298.06, 99.41 -59.28, -28.22 in-in in 8.615 Saltbr-in 2.631 HRD-in -71.59, -46.1 70.11, -9.17 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioi APE10-dihe-na -64.96, -179.87 APE9-dihe-na -56.65, 175.22 APE8-dihe-in -61.74, 128.92 APE8-rot-na 23.92 APE67-dihe-out -94.63, 6.73 -47.09, 137.23 APE12-dist-in 11.826 APE11-dist-in 13.702 APE10-dist-out 9.877 APE9-dist-in 5.1 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[62, 329]] 1.0 AF-P0C263-K1 OTHER_SBK2_HUMAN CAMK 1.1e-32 119.4 1 253 253 202 203 204 206 208 91 106 110 180 182 181 183 245 227 222 221 220 219 218 217 216 138 Serine/threonine-protein kinase SBK2
OTHER SBK2 SBK2_HUMAN AF-P0C263-K3A P0C263 54 335 348.0 No_ligand No_ligand Active DFGin 5.039 13.005 BLAminus DFGAsp-rot-in -132.36, -169.67 52.69, 73.38 202.57, 11.92 -86.32, 8.58 296.77, 103.27 -61.75, -29.29 in-in in 8.734 Saltbr-in 2.627 HRD-in -75.66, -47.04 69.13, 4.33 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -123.2, -33.63 APE9-dihe-na -76.37, 164.86 APE8-dihe-in -66.34, 128.97 APE8-rot-na 25.18 APE67-dihe-in -63.9, -11.26 -48.16, -41.76 APE12-dist-in 11.948 APE11-dist-in 11.721 APE10-dist-in 7.757 APE9-dist-in 4.634 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[62, 329]] 1.0 AF-P0C263-K3 OTHER_SBK2_HUMAN CAMK 1.1e-32 119.4 1 253 253 202 203 204 206 208 91 106 110 180 182 181 183 245 227 222 221 220 219 218 217 216 138 Serine/threonine-protein kinase SBK2
OTHER SBK3 SBK3_HUMAN AF-P0C264-K1A P0C264 35 314 359.0 No_ligand No_ligand Inactive DFGin 4.814 12.114 BLAminus DFGAsp-rot-in -121.67, -169.41 54.67, 68.38 206.2, -8.23 -81.0, 19.46 304.01, 169.08 -64.1, -30.91 in-in in 8.289 Saltbr-in 2.642 HRD-in -64.85, -46.77 63.62, 13.9 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioi APE10-dihe-na -58.37, 163.79 APE9-dihe-na -33.56, 142.68 APE8-dihe-in -59.31, 135.73 APE8-rot-na 19.89 APE67-dihe-out -89.04, 4.19 -71.64, 146.74 APE12-dist-in 12.128 APE11-dist-in 11.636 APE10-dist-out 11.38 APE9-dist-in 4.489 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[43, 306]] 1.0 AF-P0C264-K1 OTHER_SBK3_HUMAN OTHER 8.6e-27 100.4 1 250 250 182 183 184 186 188 72 87 91 160 162 161 163 224 207 202 201 200 199 198 197 196 119 Uncharacterized serine/threonine-protein kinase SBK3
OTHER SBK3 SBK3_HUMAN AF-P0C264-K3A P0C264 35 314 359.0 No_ligand No_ligand Active DFGin 4.862 12.076 BLAminus DFGAsp-rot-in -112.47, -163.62 50.04, 59.81 207.24, 0.1 -71.95, 18.25 301.1, 165.41 -66.98, -34.15 in-in in 8.469 Saltbr-in 2.647 HRD-in -69.76, -47.89 62.78, 25.5 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -80.37, -12.63 APE9-dihe-na -104.53, 155.86 APE8-dihe-in -56.73, 134.79 APE8-rot-na 336.64 APE67-dihe-in -65.89, -5.74 -53.69, -39.49 APE12-dist-in 13.987 APE11-dist-in 12.389 APE10-dist-in 7.035 APE9-dist-in 4.828 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[43, 306]] 1.0 AF-P0C264-K3 OTHER_SBK3_HUMAN OTHER 8.6e-27 100.4 1 250 250 182 183 184 186 188 72 87 91 160 162 161 163 224 207 202 201 200 199 198 197 196 119 Uncharacterized serine/threonine-protein kinase SBK3
OTHER STK16 STK16_HUMAN AF-O75716-K1A O75716 12 300 305.0 No_ligand No_ligand Active DFGin 5.11 12.989 BLAminus DFGAsp-rot-in -131.21, 177.32 65.14, 60.51 195.57, 23.58 -79.75, 7.06 308.4, 6.46 -69.52, -19.66 in-in in 8.799 Saltbr-in 2.667 HRD-in -72.4, -41.85 65.8, -22.87 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.62, -22.18 APE9-dihe-na -106.81, 121.85 APE8-dihe-in -58.6, 123.24 APE8-rot-in 302.5 APE67-dihe-in -72.26, -8.83 -54.66, -40.91 APE12-dist-in 12.767 APE11-dist-in 9.368 APE10-dist-in 4.928 APE9-dist-in 3.928 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[20, 292]] 1.0 AF-O75716-K1 OTHER_STK16_HUMAN OTHER 1.2e-40 145.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN AF-O75716-K3A O75716 12 300 305.0 No_ligand No_ligand Active DFGin 4.979 12.678 BLAminus DFGAsp-rot-in -132.79, -178.45 59.88, 51.96 202.64, 25.35 -71.46, 4.3 306.28, 9.19 -70.4, -17.29 in-in in 8.536 Saltbr-in 2.66 HRD-in -69.6, -42.96 67.71, -17.86 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.17, -21.57 APE9-dihe-na -106.77, 127.69 APE8-dihe-in -60.77, 121.9 APE8-rot-in 299.7 APE67-dihe-in -69.77, -10.89 -54.9, -44.9 APE12-dist-in 12.732 APE11-dist-in 9.54 APE10-dist-in 4.891 APE9-dist-in 3.983 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[20, 292]] 1.0 AF-O75716-K3 OTHER_STK16_HUMAN OTHER 1.2e-40 145.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJA O75716 13 299 305.0 STU:61301,STU:61302 Type1,Allosteric Active DFGin 5.288 13.003 BLAminus DFGAsp-rot-in -135.89, -178.46 61.93, 77.23 197.16, 57.93 -105.11, 26.12 316.44, 178.21 -83.9, 1.31 in-in in 9.024 Saltbr-in 2.989 HRD-in -74.11, -51.49 80.14, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.51, -7.91 APE9-dihe-na -119.57, 103.56 APE8-dihe-in -42.23, 126.34 APE8-rot-in 303.64 APE67-dihe-in -75.83, -5.68 -58.31, -41.55 APE12-dist-in 12.919 APE11-dist-in 9.177 APE10-dist-in 4.941 APE9-dist-in 4.0 R19H,R266W None None XRAY 2.6 0.187 0.229 A 317 283 4 0 0 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.9e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK16 STK16_HUMAN 2BUJB O75716 13 297 305.0 STU:61299,STU:61300 Type1,Type1 Active DFGin 5.474 13.493 BLAminus DFGAsp-rot-in -129.22, -175.67 64.04, 67.15 195.69, 11.83 -107.31, -12.83 320.05, 164.52 -59.54, -39.15 in-in in 8.947 Saltbr-in 2.374 HRD-in -61.68, -60.28 75.79, -4.77 in-in-in SNCiii in-in ActLoopNT-in 3.197 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.51, -36.93 APE9-dihe-na -101.29, 104.25 APE8-dihe-in -41.65, 126.41 APE8-rot-in 314.22 APE67-dihe-in -74.19, -9.63 -59.55, -34.23 APE12-dist-in 13.948 APE11-dist-in 10.185 APE10-dist-in 6.538 APE9-dist-in 3.697 R19H,R266W None None XRAY 2.6 0.187 0.229 B 317 277 8 0 0 0 [[20, 292]] 1.0 2buj OTHER_STK16_HUMAN OTHER 4.9e-40 143.7 1 258 258 165 166 167 169 171 49 65 69 145 147 146 148 217 202 197 196 195 194 193 192 191 99 Serine/threonine-protein kinase 16
OTHER STK35 STK35_HUMAN AF-Q8TDR2-K1A Q8TDR2 194 534 534.0 No_ligand No_ligand Active DFGin 6.279 13.892 BLAminus DFGAsp-rot-in -139.95, 178.81 60.34, 74.15 200.17, 8.6 -86.2, 18.07 290.76, 80.82 -56.1, -36.27 in-in in 8.05 Saltbr-in 2.914 HRD-in -73.04, -45.0 73.14, -11.5 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.44, 165.3 APE9-dihe-na 109.53, -166.75 APE8-dihe-in -96.5, 116.04 APE8-rot-in 305.69 APE67-dihe-in -63.0, -31.32 -43.47, -43.86 APE12-dist-in 9.631 APE11-dist-in 11.595 APE10-dist-in 6.06 APE9-dist-in 3.663 None None None AF2 -1.0 1.0 1.0 A 341 341 0 0 0 0 [[202, 526]] 1.0 AF-Q8TDR2-K1 OTHER_STK35_HUMAN OTHER 1e-46 165.5 1 254 254 380 381 382 384 386 231 247 251 357 359 358 360 436 425 420 419 418 417 416 415 414 316 Serine/threonine-protein kinase 35
OTHER STK35 STK35_HUMAN AF-Q8TDR2-K3A Q8TDR2 194 534 534.0 No_ligand No_ligand Active DFGin 6.39 13.668 BLAminus DFGAsp-rot-in -136.98, -177.7 53.8, 81.08 204.92, -21.8 -90.15, 16.25 290.78, 84.61 -58.51, -38.75 in-in in 7.868 Saltbr-in 3.14 HRD-in -80.07, -43.09 67.77, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.15, 157.14 APE9-dihe-na 123.97, 179.54 APE8-dihe-in -94.11, 124.68 APE8-rot-in 306.85 APE67-dihe-in -62.25, -12.13 -45.73, -47.34 APE12-dist-in 9.289 APE11-dist-in 11.561 APE10-dist-in 5.952 APE9-dist-in 3.343 None None None AF2 -1.0 1.0 1.0 A 341 341 0 0 0 0 [[202, 526]] 1.0 AF-Q8TDR2-K3 OTHER_STK35_HUMAN OTHER 1e-46 165.5 1 254 254 380 381 382 384 386 231 247 251 357 359 358 360 436 425 420 419 418 417 416 415 414 316 Serine/threonine-protein kinase 35
OTHER STK36 STK36_HUMAN AF-Q9NRP7-K1A Q9NRP7 1 262 1315.0 No_ligand No_ligand Active DFGin 6.425 14.314 BLAminus DFGAsp-rot-in -134.52, 179.45 59.24, 78.16 196.19, 22.13 -87.15, 17.84 292.49, 91.24 -60.43, -27.1 in-in in 9.77 Saltbr-in 2.866 HRD-in -77.34, -51.41 68.16, 10.73 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.66, 155.83 APE9-dihe-na 125.31, 174.43 APE8-dihe-in -87.36, 125.76 APE8-rot-in 300.84 APE67-dihe-in -61.71, -24.91 -51.29, -36.7 APE12-dist-in 9.21 APE11-dist-in 11.008 APE10-dist-in 5.241 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 262 262 0 0 0 0 [[4, 254]] 1.0 AF-Q9NRP7-K1 OTHER_STK36_HUMAN CAMK 1.7e-71 246.5 1 256 256 142 143 144 146 148 33 51 55 122 124 123 125 182 170 165 164 163 162 161 160 159 81 Serine/threonine-protein kinase 36
OTHER STK36 STK36_HUMAN AF-Q9NRP7-K3A Q9NRP7 1 262 1315.0 No_ligand No_ligand Active DFGin 6.128 14.382 BLAminus DFGAsp-rot-in -136.56, -176.46 57.55, 71.8 200.11, 19.06 -79.77, 15.02 293.56, 91.49 -61.34, -26.52 in-in in 9.797 Saltbr-in 2.947 HRD-in -79.0, -51.03 67.53, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.17, 151.09 APE9-dihe-na 117.08, -176.38 APE8-dihe-in -99.52, 125.13 APE8-rot-in 297.58 APE67-dihe-in -60.17, -23.38 -51.61, -38.46 APE12-dist-in 9.335 APE11-dist-in 11.222 APE10-dist-in 5.452 APE9-dist-in 3.085 None None None AF2 -1.0 1.0 1.0 A 262 262 0 0 0 0 [[4, 254]] 1.0 AF-Q9NRP7-K3 OTHER_STK36_HUMAN CAMK 1.7e-71 246.5 1 256 256 142 143 144 146 148 33 51 55 122 124 123 125 182 170 165 164 163 162 161 160 159 81 Serine/threonine-protein kinase 36
OTHER TBK1 TBK1_HUMAN AF-Q9UHD2-K1A Q9UHD2 1 312 729.0 No_ligand No_ligand Active DFGin 6.654 13.402 BLAminus DFGAsp-rot-in -145.8, -179.86 63.12, 63.14 192.76, 25.9 -77.27, 21.02 292.76, 88.61 -65.9, -20.29 in-in in 8.257 Saltbr-in 2.666 HRD-in -86.22, -47.46 65.44, 13.23 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 170.9 APE9-dihe-na 109.64, -177.4 APE8-dihe-in -118.49, 130.33 APE8-rot-in 298.73 APE67-dihe-in -67.41, -24.44 -48.1, -41.5 APE12-dist-in 8.791 APE11-dist-in 10.204 APE10-dist-in 4.741 APE9-dist-in 3.303 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 625]] 1.0 AF-Q9UHD2-K1 OTHER_TBK1_HUMAN OTHER 1.1e-42 152.3 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN AF-Q9UHD2-K3A Q9UHD2 1 312 729.0 No_ligand No_ligand Active DFGin 6.666 13.795 BLAminus DFGAsp-rot-in -151.45, -178.88 59.62, 56.99 198.51, 28.67 -72.06, 16.9 300.55, 97.86 -61.54, -19.32 in-in in 8.899 Saltbr-in 2.685 HRD-in -76.53, -46.15 69.07, 11.21 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.7, 146.22 APE9-dihe-na 139.4, -179.78 APE8-dihe-in -102.91, 129.56 APE8-rot-in 302.96 APE67-dihe-in -67.92, -20.52 -48.15, -40.83 APE12-dist-in 8.84 APE11-dist-in 10.758 APE10-dist-in 5.093 APE9-dist-in 3.924 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 625]] 1.0 AF-Q9UHD2-K3 OTHER_TBK1_HUMAN OTHER 1.1e-42 152.3 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUUA Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.885 13.708 BLAminus DFGAsp-rot-in -149.45, -171.7 60.73, 75.15 188.74, -1.16 -94.29, 22.12 284.45, 84.57 -56.95, -31.59 in-in in 8.35 Saltbr-in 2.777 HRD-in -89.96, -55.24 75.16, 8.62 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.22, 171.79 APE9-dihe-na 116.46, -167.3 APE8-dihe-in -133.65, 129.66 APE8-rot-in 296.24 APE67-dihe-in -70.89, -19.14 -44.3, -46.34 APE12-dist-in 9.025 APE11-dist-in 10.184 APE10-dist-in 4.841 APE9-dist-in 3.409 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 A 319 306 0 0 0 0 [[9, 625]] 1.0 4euu OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUUB Q9UHD2 2 307 729.0 BX7:60401 Type1 Active DFGin 6.854 13.557 BLAminus DFGAsp-rot-in -149.67, -169.25 59.25, 76.47 186.8, 3.98 -95.25, 24.67 286.86, 82.81 -60.26, -24.9 in-in in 8.312 Saltbr-in 2.823 HRD-in -94.27, -51.86 75.28, 11.95 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 163.87 APE9-dihe-na 122.52, -168.66 APE8-dihe-in -132.25, 128.66 APE8-rot-in 296.78 APE67-dihe-in -66.29, -20.21 -52.98, -41.57 APE12-dist-in 9.095 APE11-dist-in 10.127 APE10-dist-in 4.813 APE9-dist-in 3.422 D135N SEP172 SEP172 XRAY 1.8 0.17 0.194 B 319 306 0 0 0 0 [[9, 625]] 1.0 4euu OTHER_TBK1_HUMAN OTHER 5.3e-42 150.0 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTA Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.883 13.639 BLAminus DFGAsp-rot-in -159.22, -168.26 61.75, 57.03 188.04, 0.46 -82.72, 42.54 295.65, 82.26 -64.31, -31.5 in-in in 8.316 Saltbr-in 2.321 HRD-in -73.96, -54.83 84.2, -10.29 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.7, 129.45 APE9-dihe-na -58.48, -57.42 APE8-dihe-in -136.66, 145.1 APE8-rot-out 88.82 APE67-dihe-in -52.88, -19.91 -92.7, -13.2 APE12-dist-out 30.135 APE11-dist-out 24.099 APE10-dist-out 26.516 APE9-dist-out 32.471 D135N None None XRAY 2.6 0.216 0.257 A 396 382 2 0 0 0 [[9, 625]] 1.0 4eut OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4EUTB Q9UHD2 2 385 729.0 BX7:60401 Type1 Inactive DFGin 6.879 13.663 BLAminus DFGAsp-rot-in -146.55, -168.94 58.32, 68.8 182.88, 2.89 -93.86, 31.15 285.43, 84.48 -61.33, -33.63 in-in in 8.4 Saltbr-in 2.622 HRD-in -76.77, -55.1 80.6, -8.11 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.14, 115.67 APE9-dihe-na -68.94, -54.62 APE8-dihe-in -115.7, 141.18 APE8-rot-out 64.24 APE67-dihe-in -58.71, -19.7 -101.7, -8.42 APE12-dist-out 27.656 APE11-dist-out 24.127 APE10-dist-out 27.128 APE9-dist-out 33.299 D135N None None XRAY 2.6 0.216 0.257 B 396 377 7 0 0 0 [[9, 625]] 1.0 4eut OTHER_TBK1_HUMAN OTHER 9.1e-42 149.5 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IW0A Q9UHD2 2 657 729.0 BX7:60701 Type1 Active DFGin 7.242 13.902 BLAminus DFGAsp-rot-in -155.36, -171.41 57.26, 68.28 187.09, 20.13 -92.34, 33.21 293.18, 94.33 -70.66, -23.63 in-in in 9.43 Saltbr-in 2.462 HRD-in -106.67, -50.47 63.21, 19.01 in-in-in SNCiii in-in ActLoopNT-in 3.397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.9, 153.67 APE9-dihe-na 126.79, 169.6 APE8-dihe-in -88.95, 160.27 APE8-rot-in 323.58 APE67-dihe-in -68.26, -28.77 -61.06, -59.04 APE12-dist-in 9.098 APE11-dist-in 9.878 APE10-dist-in 4.64 APE9-dist-in 3.211 D135N SEP172 SEP172 XRAY 4.0 0.24 0.291 A 658 646 0 0 0 0 [[9, 625]] 1.0 4iw0 OTHER_TBK1_HUMAN OTHER 1.7e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BA Q9UHD2 2 656 729.0 BX7:60701 Type1 Inactive DFGin 8.024 14.156 BLAminus DFGAsp-rot-in -167.16, -174.99 52.37, 56.07 185.52, 18.9 -72.25, 60.65 314.15, 135.49 -69.84, -26.09 out-out out 13.196 Saltbr-out 9.426 HRD-in -76.99, -64.92 59.52, 19.15 out-in-out SNCoio in-out ActLoopNT-in 3.414 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -154.01, 141.29 APE9-dihe-na 147.45, -177.44 APE8-dihe-in -109.41, 155.1 APE8-rot-out 222.95 APE67-dihe-in -65.05, -44.47 -68.41, -46.7 APE12-dist-out 6.407 APE11-dist-in 8.827 APE10-dist-in 4.077 APE9-dist-in 4.844 D135N,S172E None None XRAY 3.4 0.244 0.258 A 665 649 0 0 0 0 [[9, 625]] 1.0 6o8b OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6O8BB Q9UHD2 2 654 729.0 BX7:60701 Type1 Inactive DFGin 6.245 13.836 BLAminus DFGAsp-rot-in -162.79, -160.44 49.62, 61.03 186.9, 8.81 -82.51, 26.39 298.43, 91.64 -59.15, -28.42 in-in in 8.939 Saltbr-in 2.335 HRD-out -92.45, 101.87 -91.5, 28.16 in-out-in SNCioi out-in ActLoopNT-out 3.718 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.24, 162.25 APE9-dihe-na 143.39, -172.96 APE8-dihe-in -120.34, 144.55 APE8-rot-in 302.76 APE67-dihe-in -62.83, -22.71 -55.27, -66.45 APE12-dist-in 8.831 APE11-dist-in 9.617 APE10-dist-in 4.333 APE9-dist-in 4.238 D135N,S172E None None XRAY 3.4 0.244 0.258 B 665 653 0 0 0 0 [[9, 625]] 1.0 6o8b OTHER_TBK1_HUMAN OTHER 3.4e-41 147.9 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6NT9A Q9UHD2 1 658 729.0 No_ligand No_ligand Inactive DFGin 6.155 14.825 BLBplus DFGAsp-rot-in -141.85, 165.55 54.68, 50.97 198.15, 1.32 -103.72, 137.33 50.05, 86.77 117.21, 999.0 out-out out 13.569 Saltbr-out 11.581 HRD-out -117.25, -179.25 -79.83, -165.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 0.32 APE8-dihe-out 58.57, 2.92 APE8-rot-out 198.03 APE67-dihe-in -83.72, -13.88 -124.64, -1.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 17.048 D135N None None EM 3.3 999.0 999.0 A 742 605 42 0 0 15 [[9, 625]] 1.0 6nt9 OTHER_TBK1_HUMAN OTHER 2.8e-41 148.4 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6NT9B Q9UHD2 1 658 729.0 No_ligand No_ligand Inactive DFGin 6.156 14.826 BLBplus DFGAsp-rot-in -141.92, 165.53 54.76, 50.86 198.16, 1.42 -103.72, 137.35 50.03, 86.82 117.26, 999.0 out-out out 13.569 Saltbr-out 11.582 HRD-out -117.26, -179.2 -79.82, -165.98 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 0.31 APE8-dihe-out 58.62, 2.94 APE8-rot-out 198.1 APE67-dihe-in -83.7, -13.99 -124.72, -1.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 17.049 D135N None None EM 3.3 999.0 999.0 B 742 605 42 0 0 15 [[9, 625]] 1.0 6nt9 OTHER_TBK1_HUMAN OTHER 2.8e-41 148.4 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 5W5VA Q9UHD2 1 657 729.0 ANW:701 Type1 Inactive DFGin 5.831 13.899 BLBplus DFGAsp-rot-in -150.83, 171.94 61.31, 54.9 186.1, 33.89 -105.86, 123.88 36.87, 102.28 102.91, 999.0 out-out out 14.215 Saltbr-out 12.302 HRD-out -104.47, 80.21 -47.11, -34.33 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.94, -19.3 999.0, -57.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.645 0.235 0.29 A 660 599 43 0 0 17 [[9, 625]] 1.0 5w5v OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BODA Q9UHD2 1 657 729.0 E0P:60801 Type1 Inactive DFGin 6.575 13.616 BLBplus DFGAsp-rot-out -152.41, 173.16 56.77, 68.29 258.81, 1.46 -131.28, 86.45 43.64, 100.08 128.88, 103.6 out-out out 13.776 Saltbr-out 10.948 HRD-out -135.05, 119.57 -77.87, -60.2 out-out-out SNCooo out-out ActLoopNT-out 12.889 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -133.1 APE8-rot-out 70.22 APE67-dihe-in -77.98, -4.52 -95.12, -38.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.197 0.228 0.271 A 660 609 33 0 0 12 [[9, 625]] 1.0 6bod OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSTA Q9UHD2 2 657 729.0 KHQ:60701 Type1 Inactive DFGin 6.515 12.967 BLBplus DFGAsp-rot-out -133.24, -163.7 58.4, 36.02 259.55, -60.6 -102.75, 143.38 34.47, 58.75 77.42, 19.32 out-out out 14.577 Saltbr-out 11.876 HRD-in -117.6, -57.3 62.17, 14.86 out-out-none SNCoon out-none ActLoopNT-out 7.8 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -59.52 APE8-dihe-in -104.7, 130.68 APE8-rot-in 322.96 APE67-dihe-in -82.91, 1.1 -67.49, -27.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.885 None None None XRAY 3.29 0.249 0.303 A 663 625 22 0 0 10 [[9, 625]] 1.0 6rst OTHER_TBK1_HUMAN OTHER 9.6e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWOA Q9UHD2 2 657 729.0 1H4:60701 Type1 Inactive DFGin 7.191 14.124 BLBplus DFGAsp-rot-in -153.61, 168.75 57.39, 50.65 207.43, 30.84 -116.36, 158.83 38.99, 72.82 92.33, 6.5 out-out out 13.564 Saltbr-out 10.364 HRD-in -110.09, -64.46 67.55, -18.09 out-out-none SNCoon out-none ActLoopNT-out 7.73 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.3 APE8-dihe-in -75.55, 152.96 APE8-rot-in 319.78 APE67-dihe-in -87.48, 0.06 -52.74, -52.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.371 S172A None None XRAY 2.61 0.246 0.263 A 660 625 22 0 0 10 [[9, 625]] 1.0 4iwo OTHER_TBK1_HUMAN OTHER 8.2e-42 149.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM0A Q9UHD2 1 657 729.0 1FV:60701 Type1 Inactive DFGin 6.812 13.242 BLBplus DFGAsp-rot-in -149.79, 171.47 60.81, 53.02 185.73, 33.87 -106.92, 124.0 22.99, 96.98 102.91, 999.0 out-out out 12.959 Saltbr-out 11.171 HRD-out -103.53, 81.55 -45.92, -34.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.43 APE8-rot-none 999.0 APE67-dihe-in -65.07, -18.91 -41.27, -57.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 2.4 0.201 0.236 A 663 617 26 0 0 16 [[9, 625]] 1.0 4im0 OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM2A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.075 13.137 BLBplus DFGAsp-rot-in -136.28, 173.8 65.75, 52.9 184.34, 35.06 -107.95, 125.12 18.78, 94.0 108.02, 999.0 out-out out 12.986 Saltbr-out 11.517 HRD-out -95.3, 97.77 -57.37, -35.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.8 APE8-rot-none 999.0 APE67-dihe-in -56.86, -20.77 -32.3, -61.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 2.5 0.2 0.255 A 663 616 26 0 0 16 [[9, 625]] 1.0 4im2 OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IM3A Q9UHD2 1 657 729.0 BX7:60701 Type1 Inactive DFGin 7.954 13.233 BLBplus DFGAsp-rot-in -150.28, 172.42 61.6, 53.39 185.99, 33.98 -107.06, 123.71 23.03, 90.43 -109.41, 999.0 out-out out 14.891 Saltbr-out 13.161 HRD-out -102.64, 82.39 -45.52, -34.46 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D135N None None XRAY 3.342 0.223 0.279 A 663 603 44 0 0 24 [[9, 625]] 1.0 4im3 OTHER_TBK1_HUMAN OTHER 4.4e-41 148.6 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BNYA Q9UHD2 1 657 729.0 E0M:801 Type1 Inactive DFGin 6.871 14.259 None DFGAsp-rot-in -144.13, -26.45 -127.29, 108.83 207.65, 80.3 -162.84, 152.36 47.44, 84.0 75.64, 999.0 out-out out 14.755 Saltbr-out 12.92 HRD-in -102.85, -58.68 62.76, -53.68 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.55 APE8-rot-in 310.76 APE67-dihe-in -67.57, -21.0 -66.63, -30.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.341 0.233 0.287 A 660 609 34 0 0 16 [[9, 625]] 1.0 6bny OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6BOEA Q9UHD2 1 657 729.0 E0S:60701 Type1 Inactive DFGin 6.919 14.034 None DFGAsp-rot-in -140.29, -57.72 -92.01, 95.65 185.46, 74.85 -150.11, 999.0 50.59, 85.3 999.0, 999.0 out-out out 14.238 Saltbr-out 11.896 HRD-in -100.51, -43.17 59.35, -67.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -167.84 APE8-dihe-in -93.97, 148.54 APE8-rot-in 317.28 APE67-dihe-in -97.0, -14.84 -58.66, -27.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.898 None None None XRAY 3.598 0.246 0.291 A 660 599 46 0 0 16 [[9, 625]] 1.0 6boe OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ0A Q9UHD2 1 657 729.0 F8M:60801 Type1 Inactive DFGin 7.058 14.17 None DFGAsp-rot-in -145.32, -48.95 -97.67, 99.43 186.78, 71.46 -150.2, 69.66 41.19, 106.47 -153.94, 166.29 out-out out 14.62 Saltbr-out 12.493 HRD-in -82.5, -25.39 61.31, -62.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -74.47 APE8-dihe-in -121.62, 145.83 APE8-rot-in 316.01 APE67-dihe-in -80.24, -16.92 -66.55, -39.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.052 None None None XRAY 3.19 0.24 0.293 A 660 603 40 0 0 14 [[9, 625]] 1.0 6cq0 OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ4A Q9UHD2 1 657 729.0 F8P:60801 Type1 Inactive DFGin 6.982 14.197 None DFGAsp-rot-in -148.33, -48.83 -93.41, 87.11 189.76, 66.07 -146.09, 999.0 49.51, 84.45 999.0, 999.0 out-out out 14.546 Saltbr-out 12.73 HRD-in -82.2, -27.57 62.97, -55.42 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -72.21 APE8-dihe-in -126.99, 151.01 APE8-rot-in 318.15 APE67-dihe-in -74.77, -17.35 -67.05, -46.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.72 None None None XRAY 3.2 0.235 0.272 A 660 603 40 0 0 16 [[9, 625]] 1.0 6cq4 OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6CQ5A Q9UHD2 1 657 729.0 F8S:60801 Type1 Inactive DFGin 6.717 14.179 None DFGAsp-rot-in -145.73, -48.48 -97.16, 93.96 189.22, 68.98 -153.08, 999.0 53.79, 88.24 999.0, 999.0 out-out out 14.617 Saltbr-out 12.64 HRD-in -85.7, -26.16 62.99, -56.36 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -79.38, -18.02 999.0, -39.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.354 0.233 0.275 A 660 601 42 0 0 18 [[9, 625]] 1.0 6cq5 OTHER_TBK1_HUMAN OTHER 4.5e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSRA Q9UHD2 2 657 729.0 KHT:60900 Type1 Inactive DFGin 6.997 13.955 None DFGAsp-rot-in -156.53, -62.85 -81.29, 81.31 188.29, 53.25 -143.8, 159.0 54.44, 89.38 84.08, 8.25 out-out out 14.117 Saltbr-out 11.958 HRD-in -102.36, -69.73 73.33, -20.77 out-out-none SNCoon out-none ActLoopNT-out 8.041 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.29 APE8-dihe-in -74.97, 146.4 APE8-rot-in 310.67 APE67-dihe-in -80.54, -16.93 -52.28, -36.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.915 None None None XRAY 3.15 0.282 0.307 A 663 625 22 0 0 10 [[9, 625]] 1.0 6rsr OTHER_TBK1_HUMAN OTHER 9.6e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 6RSUA Q9UHD2 2 657 729.0 KJB:60701 Type1 Inactive DFGin 6.638 14.113 None DFGAsp-rot-in -154.16, -13.81 -149.75, 80.99 172.12, -86.37 -136.99, 156.49 58.38, 98.61 87.97, 3.83 out-out out 13.665 Saltbr-out 10.528 HRD-in -95.03, -62.14 77.79, -56.35 out-out-none SNCoon out-none ActLoopNT-out 8.376 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.58 APE8-dihe-in -74.98, 144.67 APE8-rot-in 310.9 APE67-dihe-in -80.01, -17.92 -55.62, -36.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.473 None None None XRAY 2.75 0.292 0.351 A 663 625 22 0 0 10 [[9, 625]] 1.0 6rsu OTHER_TBK1_HUMAN OTHER 9.6e-42 150.8 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWPA Q9UHD2 2 657 729.0 BX7:60701 Type1 Inactive DFGin 7.288 13.414 None DFGAsp-rot-in -134.43, -56.21 -87.24, 102.18 186.86, 33.29 -162.15, 172.63 51.08, 85.4 74.44, 12.62 out-out out 14.153 Saltbr-out 13.317 HRD-in -97.28, -65.46 67.49, -12.98 out-out-none SNCoon out-none ActLoopNT-out 7.893 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.34 APE8-dihe-in -75.67, 146.05 APE8-rot-in 314.2 APE67-dihe-in -83.23, -17.66 -52.37, -34.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.56 S172A None None XRAY 3.065 0.283 0.335 A 659 625 22 0 0 10 [[9, 625]] 1.0 4iwp OTHER_TBK1_HUMAN OTHER 8.2e-42 149.7 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TBK1 TBK1_HUMAN 4IWQA Q9UHD2 2 657 729.0 1FV:60701 Type1 Inactive DFGin 6.986 13.54 None DFGAsp-rot-in -151.26, -54.27 -82.9, 74.22 193.97, 32.01 -133.51, 165.85 51.03, 84.3 72.58, 18.91 out-out out 13.655 Saltbr-out 10.978 HRD-in -91.75, -57.98 64.75, -44.39 out-out-none SNCoon out-none ActLoopNT-out 7.834 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.51 APE8-dihe-in -69.41, 148.35 APE8-rot-in 313.75 APE67-dihe-in -92.47, 5.0 -54.53, -34.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.136 S172A None None XRAY 3.0 0.264 0.31 A 659 623 22 0 0 10 [[9, 625]] 1.0 4iwq OTHER_TBK1_HUMAN OTHER 8.2e-42 149.7 2 255 254 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Serine/threonine-protein kinase TBK1
OTHER TLK1 TLK1_HUMAN AF-Q9UKI8-K1A Q9UKI8 448 742 766.0 No_ligand No_ligand Active DFGin 5.994 14.949 BLAminus DFGAsp-rot-in -145.74, 177.32 67.19, 79.63 197.47, 22.14 -89.53, 15.21 292.96, 84.41 -61.02, -26.24 in-in in 9.796 Saltbr-in 3.012 HRD-in -67.02, -42.32 70.39, -22.9 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.28, 155.84 APE9-dihe-na 99.17, 179.82 APE8-dihe-in -99.87, 102.88 APE8-rot-in 311.15 APE67-dihe-in -62.14, -25.53 -56.71, -32.46 APE12-dist-in 12.242 APE11-dist-in 11.171 APE10-dist-in 6.537 APE9-dist-in 5.185 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[456, 734]] 1.0 AF-Q9UKI8-K1 OTHER_TLK1_HUMAN CAMK 3.2e-53 186.7 1 256 256 606 607 608 610 612 485 508 512 583 585 584 586 656 640 635 634 633 632 631 630 629 539 Serine/threonine-protein kinase tousled-like 1
OTHER TLK1 TLK1_HUMAN AF-Q9UKI8-K3A Q9UKI8 448 742 766.0 No_ligand No_ligand Active DFGin 6.225 14.988 BLAminus DFGAsp-rot-in -136.42, -179.97 64.58, 66.83 195.86, 30.22 -79.55, 10.15 290.22, 85.96 -57.27, -33.29 in-in in 9.996 Saltbr-in 3.504 HRD-in -67.46, -42.22 70.87, -34.48 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.22, 163.79 APE9-dihe-na 83.9, 177.94 APE8-dihe-in -102.26, 108.83 APE8-rot-in 307.82 APE67-dihe-in -61.06, -29.54 -59.28, -31.72 APE12-dist-in 12.276 APE11-dist-in 11.197 APE10-dist-in 6.496 APE9-dist-in 5.437 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[456, 734]] 1.0 AF-Q9UKI8-K3 OTHER_TLK1_HUMAN CAMK 3.2e-53 186.7 1 256 256 606 607 608 610 612 485 508 512 583 585 584 586 656 640 635 634 633 632 631 630 629 539 Serine/threonine-protein kinase tousled-like 1
OTHER TLK2 TLK2_HUMAN 5O0YA Q86UE8 456 743 772.0 AGS:801 ATPlike Inactive DFGin 5.838 16.696 BLAminus DFGAsp-rot-in -154.54, -173.82 64.72, 68.79 200.69, -20.87 -84.13, 30.07 299.95, 83.25 -66.33, -38.04 out-out out 11.511 Saltbr-out 5.972 HRD-out -83.23, 94.84 -74.56, -13.23 out-in-in SNCoii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.76, 159.55 APE9-dihe-na 89.86, 175.53 APE8-dihe-in -96.42, 113.01 APE8-rot-in 322.47 APE67-dihe-in -58.01, -37.07 -65.88, -24.96 APE12-dist-in 12.082 APE11-dist-in 11.012 APE10-dist-in 6.419 APE9-dist-in 5.74 None None None XRAY 2.86 0.184 0.21 A 579 288 0 0 0 0 [[462, 741]] 1.0 5o0y OTHER_TLK2_HUMAN CAMK 6.8e-54 190.4 1 256 256 612 613 614 616 618 491 514 518 589 591 590 592 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
OTHER TLK2 TLK2_HUMAN AF-Q86UE8-K1A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.172 14.765 BLAminus DFGAsp-rot-in -133.44, 173.75 65.52, 77.57 198.98, 19.34 -86.26, 14.3 290.35, 85.15 -60.94, -21.52 in-in in 9.646 Saltbr-in 2.968 HRD-in -67.77, -42.33 69.71, -22.37 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.36, 150.82 APE9-dihe-na 103.81, -179.58 APE8-dihe-in -98.64, 104.09 APE8-rot-in 310.42 APE67-dihe-in -62.26, -26.61 -57.48, -33.84 APE12-dist-in 12.515 APE11-dist-in 11.203 APE10-dist-in 6.511 APE9-dist-in 5.103 None None None AF2 -1.0 1.0 1.0 A 296 296 0 0 0 0 [[462, 741]] 1.0 AF-Q86UE8-K1 OTHER_TLK2_HUMAN CAMK 8.6e-55 191.8 1 256 256 612 613 614 616 618 491 514 518 589 591 590 592 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
OTHER TLK2 TLK2_HUMAN AF-Q86UE8-K3A Q86UE8 454 749 772.0 No_ligand No_ligand Active DFGin 6.004 14.821 BLAminus DFGAsp-rot-in -138.69, -179.61 62.35, 72.79 194.18, 25.55 -84.32, 12.52 293.62, 90.0 -58.65, -30.26 in-in in 9.966 Saltbr-in 3.544 HRD-in -65.79, -40.16 70.43, -37.62 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.14, 149.84 APE9-dihe-na 93.2, -177.93 APE8-dihe-in -97.14, 108.48 APE8-rot-in 311.99 APE67-dihe-in -63.12, -30.35 -57.44, -34.76 APE12-dist-in 12.514 APE11-dist-in 11.135 APE10-dist-in 6.473 APE9-dist-in 5.738 None None None AF2 -1.0 1.0 1.0 A 296 296 0 0 0 0 [[462, 741]] 1.0 AF-Q86UE8-K3 OTHER_TLK2_HUMAN CAMK 8.6e-55 191.8 1 256 256 612 613 614 616 618 491 514 518 589 591 590 592 663 647 642 641 640 639 638 637 636 545 Serine/threonine-protein kinase tousled-like 2
OTHER TP53RK PRPK_HUMAN 6WQXC Q96S44 17 247 253.0 ANP:301 ATPlike Active DFGin 5.95 14.251 BLAminus DFGAsp-rot-in -146.19, 177.42 55.9, 80.94 208.1, -3.87 -109.82, 15.46 288.95, 83.65 -50.48, -21.92 in-in in 7.493 Saltbr-in 2.923 HRD-in -69.98, -47.0 96.04, -14.43 in-in-na SNCiia in-na ActLoopNT-in 2.804 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.54, -42.02 APE9-dihe-na -66.2, -40.19 APE8-dihe-na -55.79, -43.62 APE8-rot-na 183.14 APE67-dihe-na -65.72, -35.03 -54.78, -48.19 APE12-dist-na 16.724 APE11-dist-na 12.036 APE10-dist-na 14.577 APE9-dist-na 11.741 None None None XRAY 2.53 0.214 0.265 C 267 231 6 0 0 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD Q96S44 18 247 253.0 ANP:301 ATPlike Active DFGin 6.043 14.258 BLAminus DFGAsp-rot-in -133.24, 171.19 66.42, 73.64 215.52, -8.93 -108.34, 16.47 289.91, 91.17 -66.2, -15.73 in-in in 7.377 Saltbr-in 2.505 HRD-in -60.03, -49.96 100.64, -20.8 in-in-na SNCiia in-na ActLoopNT-in 2.816 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.35, -39.45 APE9-dihe-na -58.51, -49.84 APE8-dihe-na -58.36, -37.8 APE8-rot-na 168.78 APE67-dihe-na -71.45, -37.84 -63.19, -40.46 APE12-dist-na 16.676 APE11-dist-na 12.07 APE10-dist-na 14.499 APE9-dist-na 11.469 None None None XRAY 2.53 0.214 0.265 D 267 230 6 0 0 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN AF-Q96S44-K1A Q96S44 25 253 253.0 No_ligand No_ligand Active DFGin 5.483 14.572 BLAminus DFGAsp-rot-in -133.01, 167.26 60.85, 61.97 204.02, -11.73 -77.79, 29.67 286.05, 90.77 -68.56, -19.76 in-in in 7.655 Saltbr-in 2.703 HRD-in -80.02, -43.01 78.89, 2.67 in-in-na SNCiia in-na ActLoopNT-in 2.869 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -65.8, -40.37 APE9-dihe-na -64.19, -40.19 APE8-dihe-na -64.5, -43.65 APE8-rot-na 172.84 APE67-dihe-na -63.62, -38.23 -62.03, -42.21 APE12-dist-na 16.315 APE11-dist-na 11.686 APE10-dist-na 14.488 APE9-dist-na 11.811 None None None AF2 -1.0 1.0 1.0 A 229 229 0 0 0 0 [[32, 253]] 1.0 AF-Q96S44-K1 OTHER_TP53RK_HUMAN TP53RK 6.9e-115 388.1 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN AF-Q96S44-K3A Q96S44 25 253 253.0 No_ligand No_ligand Active DFGin 5.567 14.693 BLAminus DFGAsp-rot-in -134.88, 172.74 57.43, 51.61 204.16, -6.09 -71.81, 29.96 286.39, 91.42 -71.14, -17.74 in-in in 7.616 Saltbr-in 2.688 HRD-in -80.35, -41.57 77.35, 2.98 in-in-na SNCiia in-na ActLoopNT-in 2.877 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.47, -39.25 APE9-dihe-na -66.89, -37.13 APE8-dihe-na -65.81, -43.02 APE8-rot-na 171.28 APE67-dihe-na -63.45, -35.24 -63.76, -41.61 APE12-dist-na 16.41 APE11-dist-na 11.726 APE10-dist-na 14.522 APE9-dist-na 11.883 None None None AF2 -1.0 1.0 1.0 A 229 229 0 0 0 0 [[32, 253]] 1.0 AF-Q96S44-K3 OTHER_TP53RK_HUMAN TP53RK 6.9e-115 388.1 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 9FL9B Q96S44 18 247 253.0 No_ligand No_ligand Inactive DFGin 6.429 14.424 BLAminus DFGAsp-rot-in -129.56, -175.64 50.68, 64.19 200.26, -43.28 -93.48, 55.28 294.43, 92.08 -89.78, -37.52 in-out in 7.2 Saltbr-out 5.714 HRD-in -52.79, -21.8 70.67, -20.78 out-in-na SNCoia in-na ActLoopNT-in 3.229 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.11, -44.39 APE9-dihe-na -60.47, -36.15 APE8-dihe-na -56.88, -47.48 APE8-rot-na 159.0 APE67-dihe-na -59.17, -29.38 -56.52, -55.75 APE12-dist-na 16.892 APE11-dist-na 11.888 APE10-dist-na 14.798 APE9-dist-na 10.569 None None None EM 3.74 999.0 999.0 B 266 230 6 0 0 0 [[32, 253]] 1.0 9fl9 OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.4 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZAA Q96S44 14 246 253.0 DUI:60501 Type1 Inactive DFGin 6.216 14.527 BLAminus DFGAsp-rot-out -137.68, 167.57 63.95, 71.33 282.21, -3.98 -97.12, 22.5 288.3, 82.76 -66.52, -23.15 in-in in 7.473 Saltbr-in 2.706 HRD-in -67.59, -46.42 92.57, -16.73 in-in-na SNCiia in-na ActLoopNT-in 2.807 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -65.86, -36.07 APE9-dihe-na -65.07, -41.44 APE8-dihe-na -64.72, -39.84 APE8-rot-na 171.56 APE67-dihe-na -64.95, -31.34 -51.72, -53.07 APE12-dist-na 16.512 APE11-dist-na 11.918 APE10-dist-na 14.57 APE9-dist-na 11.678 None None None XRAY 1.9 0.175 0.216 A 255 233 7 0 0 0 [[32, 253]] 1.0 7sza OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZAC Q96S44 18 245 253.0 DUI:60301 Type1 Inactive DFGin 6.261 14.61 BLAminus DFGAsp-rot-out -136.44, 167.49 64.07, 70.95 281.32, -1.31 -96.97, 22.4 288.63, 83.56 -64.78, -22.37 in-in in 7.428 Saltbr-in 2.738 HRD-in -69.19, -46.56 92.81, -16.35 in-in-na SNCiia in-na ActLoopNT-in 2.783 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.18, -37.49 APE9-dihe-na -67.28, -39.26 APE8-dihe-na -61.85, -40.32 APE8-rot-na 164.52 APE67-dihe-na -65.78, -33.42 -52.7, -50.93 APE12-dist-na 16.565 APE11-dist-na 11.942 APE10-dist-na 14.487 APE9-dist-na 11.639 None None None XRAY 1.9 0.175 0.216 C 255 225 11 0 0 0 [[32, 253]] 1.0 7sza OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZBA Q96S44 14 245 253.0 DQ4:60301 Type1 Active DFGin 6.198 14.475 BLAminus DFGAsp-rot-in -138.16, 167.23 65.96, 74.2 193.89, -8.62 -100.13, 22.67 291.73, 84.26 -64.29, -20.59 in-in in 7.571 Saltbr-in 2.841 HRD-in -65.89, -49.76 99.33, -11.92 in-in-na SNCiia in-na ActLoopNT-in 2.817 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.8, -36.58 APE9-dihe-na -63.43, -43.17 APE8-dihe-na -64.83, -42.66 APE8-rot-na 167.91 APE67-dihe-na -64.4, -38.42 -48.03, -50.96 APE12-dist-na 16.53 APE11-dist-na 11.962 APE10-dist-na 14.599 APE9-dist-na 11.72 None None None XRAY 2.02 0.172 0.209 A 255 232 8 0 0 0 [[32, 253]] 1.0 7szb OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZBC Q96S44 18 245 253.0 DQ4:60301 Type1 Active DFGin 6.217 14.555 BLAminus DFGAsp-rot-in -133.25, 168.54 63.3, 76.47 190.54, -2.12 -104.4, 26.73 289.18, 82.2 -64.87, -24.94 in-in in 7.403 Saltbr-in 2.583 HRD-in -73.97, -43.91 95.55, -14.35 in-in-na SNCiia in-na ActLoopNT-in 2.849 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.88, -39.61 APE9-dihe-na -64.3, -41.9 APE8-dihe-na -62.52, -39.03 APE8-rot-na 167.51 APE67-dihe-na -74.02, -33.24 -57.23, -40.86 APE12-dist-na 16.439 APE11-dist-na 11.839 APE10-dist-na 14.511 APE9-dist-na 11.691 None None None XRAY 2.02 0.172 0.209 C 255 226 10 0 0 0 [[32, 253]] 1.0 7szb OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZCA Q96S44 18 246 253.0 DO0:64002 Type1 Inactive DFGin 6.355 14.674 BLAminus DFGAsp-rot-out -136.53, 166.38 65.74, 68.83 293.32, -8.3 -96.94, 22.86 285.34, 84.38 -62.09, -29.11 in-in in 7.497 Saltbr-in 3.038 HRD-in -69.56, -45.14 95.78, -18.18 in-in-na SNCiia in-na ActLoopNT-in 2.848 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.99, -37.48 APE9-dihe-na -62.34, -41.45 APE8-dihe-na -64.28, -41.4 APE8-rot-na 169.78 APE67-dihe-na -70.65, -38.19 -55.04, -45.13 APE12-dist-na 16.659 APE11-dist-na 11.992 APE10-dist-na 14.544 APE9-dist-na 11.678 None None None XRAY 1.71 0.179 0.207 A 255 229 7 0 0 0 [[32, 253]] 1.0 7szc OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZCC Q96S44 18 246 253.0 DO0:64002 Type1 Inactive DFGin 6.392 14.75 BLAminus DFGAsp-rot-out -134.53, 167.03 65.8, 70.64 295.08, -9.16 -98.45, 24.39 284.79, 86.98 -66.49, -23.65 in-in in 7.665 Saltbr-in 3.01 HRD-in -69.44, -44.0 93.39, -16.24 in-in-na SNCiia in-na ActLoopNT-in 2.831 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.82, -39.61 APE9-dihe-na -61.14, -41.22 APE8-dihe-na -65.94, -38.57 APE8-rot-na 166.07 APE67-dihe-na -73.2, -37.73 -57.21, -42.78 APE12-dist-na 16.779 APE11-dist-na 12.136 APE10-dist-na 14.678 APE9-dist-na 11.758 None None None XRAY 1.71 0.179 0.207 C 255 223 13 0 0 0 [[32, 253]] 1.0 7szc OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZDA Q96S44 18 249 253.0 DVO:64000 Type1 Active DFGin 6.074 14.662 BLAminus DFGAsp-rot-in -143.5, 165.08 70.69, 78.79 215.44, -0.68 -108.16, 22.96 278.46, 89.15 -63.65, -29.99 in-in in 7.605 Saltbr-in 2.834 HRD-in -71.25, -44.33 98.58, -18.28 in-in-na SNCiia in-na ActLoopNT-in 2.769 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.55, -33.99 APE9-dihe-na -63.57, -45.84 APE8-dihe-na -68.97, -27.35 APE8-rot-na 168.55 APE67-dihe-na -74.69, -27.01 -65.39, -39.62 APE12-dist-na 16.746 APE11-dist-na 12.054 APE10-dist-na 14.476 APE9-dist-na 11.652 None None None XRAY 2.05 0.223 0.275 A 255 232 4 0 0 0 [[32, 253]] 1.0 7szd OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 7SZDC Q96S44 18 249 253.0 DVO:64000 Type1 Active DFGin 6.26 14.55 BLAminus DFGAsp-rot-in -142.45, 163.97 67.33, 80.98 219.87, -28.42 -110.12, 24.57 283.8, 96.89 -62.82, -28.46 in-in in 7.506 Saltbr-in 3.254 HRD-in -71.26, -45.42 96.12, -16.48 in-in-na SNCiia in-na ActLoopNT-in 2.878 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.01, -29.73 APE9-dihe-na -63.12, -49.92 APE8-dihe-na -73.12, -21.73 APE8-rot-na 306.69 APE67-dihe-na -76.23, -25.87 -62.6, -40.57 APE12-dist-na 16.757 APE11-dist-na 12.147 APE10-dist-na 14.401 APE9-dist-na 11.757 None None None XRAY 2.05 0.223 0.275 C 255 232 4 0 0 0 [[32, 253]] 1.0 7szd OTHER_TP53RK_HUMAN TP53RK 1e-114 387.5 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TTK TTK_HUMAN 3HMNA P33981 516 794 857.0 ATP:1 ATPlike Inactive DFGin 3.999 14.991 ABAminus DFGAsp-rot-out -98.05, -9.81 -153.31, 160.67 77.91, -37.59 -110.5, 6.35 307.22, 150.55 69.66, 19.48 out-out out 10.962 Saltbr-out 6.528 HRD-in -68.45, -50.57 72.29, 2.18 out-out-out SNCooo out-out ActLoopNT-out 11.646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 102.39 APE9-dihe-na -78.34, -151.63 APE8-dihe-in -168.7, 144.18 APE8-rot-in 299.37 APE67-dihe-in -66.82, -19.22 -122.77, 14.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.622 APE9-dist-out 12.191 None None None XRAY 2.7 0.223 0.265 A 342 255 24 0 0 12 [[525, 791]] 1.0 3hmn OTHER_TTK_HUMAN CAMK 1.2e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3CEKA P33981 519 794 857.0 No_ligand No_ligand Inactive DFGin 4.148 15.088 ABAminus DFGAsp-rot-in -98.03, -14.36 -147.33, 142.24 179.55, 75.13 -107.5, -0.94 300.98, 162.57 82.4, 8.93 out-out out 11.101 Saltbr-out 6.573 HRD-in -63.8, -55.54 78.98, -2.7 out-out-out SNCooo out-out ActLoopNT-out 10.641 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.03 APE8-dihe-out -135.87, -42.68 APE8-rot-none 999.0 APE67-dihe-in -70.42, -22.06 -66.07, -16.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.277 None None None XRAY 2.3 0.188 0.25 A 313 252 24 0 0 14 [[525, 791]] 1.0 3cek OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3DBQA P33981 515 796 857.0 No_ligand No_ligand Inactive DFGin 4.218 15.626 ABAminus DFGAsp-rot-out -82.17, -30.42 -141.36, 167.61 66.73, -73.97 -106.63, 0.96 290.84, 175.03 70.86, 9.96 out-out out 10.351 Saltbr-out 6.591 HRD-in -57.38, -50.92 66.46, 1.19 out-out-out SNCooo out-out ActLoopNT-out 11.254 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 166.38 APE9-dihe-na 117.73, 69.71 APE8-dihe-in -75.54, 158.78 APE8-rot-in 302.2 APE67-dihe-in -74.9, -25.39 -128.59, 17.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.788 APE9-dist-out 11.721 None None None XRAY 2.7 0.226 0.285 A 343 259 23 0 0 12 [[525, 791]] 1.0 3dbq OTHER_TTK_HUMAN CAMK 1.2e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 2ZMCA P33981 516 794 857.0 No_ligand No_ligand Inactive DFGin 4.045 15.361 ABAminus DFGAsp-rot-in -102.63, 6.43 -172.08, 140.67 148.99, 59.69 -107.12, 4.47 303.66, 149.3 60.1, 32.65 out-out out 11.316 Saltbr-out 5.811 HRD-in -51.44, -51.77 70.45, 12.69 out-out-out SNCooo out-out ActLoopNT-out 10.588 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -148.16, 52.12 APE9-dihe-na -110.91, 95.2 APE8-dihe-in -78.12, 144.82 APE8-rot-in 328.93 APE67-dihe-in -59.32, -21.8 -101.22, 8.95 APE12-dist-out 22.842 APE11-dist-out 21.011 APE10-dist-out 19.496 APE9-dist-out 11.454 None None None XRAY 3.14 0.226 0.289 A 390 260 19 0 0 9 [[525, 791]] 1.0 2zmc OTHER_TTK_HUMAN CAMK 1.8e-53 187.6 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6GVJA P33981 515 795 857.0 No_ligand No_ligand Inactive DFGin 4.19 15.386 ABAminus DFGAsp-rot-out -94.09, -39.51 -142.2, 169.22 56.32, 84.8 -115.27, 12.46 297.03, 156.51 66.91, 11.36 out-out out 10.725 Saltbr-out 9.286 HRD-in -64.5, -59.44 84.15, 4.87 out-out-out SNCooo out-out ActLoopNT-out 11.812 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -96.72, 154.33 APE9-dihe-na 116.29, 95.4 APE8-dihe-in -94.84, 145.96 APE8-rot-out 191.9 APE67-dihe-in -63.51, -23.75 -95.29, 10.45 APE12-dist-out 22.099 APE11-dist-out 23.613 APE10-dist-out 18.837 APE9-dist-out 11.483 None None None XRAY 2.41 0.203 0.233 A 429 272 9 0 0 0 [[525, 791]] 1.0 6gvj OTHER_TTK_HUMAN CAMK 2.4e-53 187.2 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5NTTA P33981 519 797 857.0 SVE:60801 Type1 Inactive DFGin 4.05 15.12 ABAminus DFGAsp-rot-out -86.34, -42.9 -137.69, 167.25 73.48, -35.52 -111.84, 11.03 299.57, 162.1 66.85, 16.85 out-out out 10.98 Saltbr-out 5.922 HRD-in -63.1, -49.38 74.04, 9.83 out-out-out SNCooo out-out ActLoopNT-out 11.501 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -72.45, -49.0 APE9-dihe-na -71.51, -26.39 APE8-dihe-in -34.25, 137.42 APE8-rot-none 999.0 APE67-dihe-in -68.38, -17.02 -109.78, 8.89 APE12-dist-out 22.273 APE11-dist-out 18.532 APE10-dist-out 15.69 APE9-dist-out 11.551 C604Y TPO686 TPO686 XRAY 2.75 0.201 0.23 A 287 269 10 0 0 0 [[525, 791]] 1.0 5ntt OTHER_TTK_HUMAN CAMK 4.3e-54 189.5 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5LJJA P33981 519 795 857.0 AD5:60901 Type1 Inactive DFGin 4.33 14.853 ABAminus DFGAsp-rot-in -81.43, -35.19 -129.4, 134.9 176.57, 65.49 -96.53, 6.93 283.88, 13.64 82.2, 19.77 out-out out 10.061 Saltbr-out 3.967 HRD-in -54.64, -37.72 72.33, -52.21 out-out-out SNCooo out-out ActLoopNT-out 12.138 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -74.59, 157.14 APE9-dihe-na -95.35, -179.33 APE8-dihe-out -73.32, -32.03 APE8-rot-in 319.71 APE67-dihe-in -53.22, -30.68 -79.48, -20.83 APE12-dist-out 22.536 APE11-dist-out 24.573 APE10-dist-out 19.884 APE9-dist-out 14.072 C604Y None None XRAY 3.0 0.228 0.268 A 313 260 17 0 0 5 [[525, 791]] 1.0 5ljj OTHER_TTK_HUMAN CAMK 5.9e-54 189.2 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5MRBA P33981 519 795 857.0 C5N:60901 Type1 Inactive DFGin 3.99 15.055 ABAminus DFGAsp-rot-out -88.14, -37.43 -145.51, 169.37 80.2, -42.3 -114.29, 5.64 296.03, 167.61 72.21, 9.85 out-out out 11.204 Saltbr-out 6.075 HRD-in -67.77, -54.4 68.39, 11.32 out-out-out SNCooo out-out ActLoopNT-out 11.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -119.93, 125.86 APE9-dihe-na 65.05, 26.68 APE8-dihe-in -57.09, 145.6 APE8-rot-out 189.99 APE67-dihe-in -63.9, -20.76 -103.43, 7.11 APE12-dist-none 999.0 APE11-dist-out 21.193 APE10-dist-out 18.501 APE9-dist-out 10.56 C604Y None None XRAY 2.2 0.175 0.216 A 313 259 18 0 0 5 [[525, 791]] 1.0 5mrb OTHER_TTK_HUMAN CAMK 5.9e-54 189.2 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EH0A P33981 516 794 857.0 5NW:801 Type1 Inactive DFGin 4.285 14.957 ABAminus DFGAsp-rot-out -70.51, -43.24 -138.73, 164.35 65.47, 15.6 -108.25, 7.22 296.58, 162.45 73.13, 1.25 out-out out 10.749 Saltbr-out 5.978 HRD-in -63.67, -57.11 75.04, -3.07 out-out-out SNCooo out-out ActLoopNT-out 11.534 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.74 APE8-dihe-in -112.66, 155.78 APE8-rot-out 188.67 APE67-dihe-in -62.69, -27.07 -106.54, 4.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.884 None None None XRAY 2.18 0.198 0.216 A 279 258 21 0 0 10 [[525, 791]] 1.0 5eh0 OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6H3KA P33981 519 794 857.0 FMW:60801 Type1 Inactive DFGin 4.289 15.06 ABAminus DFGAsp-rot-out -78.15, -56.1 -128.46, 166.12 61.63, -83.28 -108.06, 3.12 300.73, 163.62 73.15, 6.23 out-out out 10.843 Saltbr-out 5.6 HRD-in -55.05, -54.84 64.62, 9.92 out-out-out SNCooo out-out ActLoopNT-out 11.845 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.7 APE8-rot-out 181.2 APE67-dihe-in -63.91, -24.73 -102.23, 3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.48 0.209 0.231 A 279 254 22 0 0 12 [[525, 791]] 1.0 6h3k OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4JS8A P33981 515 793 857.0 1PF:801 Type1 Inactive DFGin 4.246 15.018 ABAminus DFGAsp-rot-out -84.57, -49.34 -133.98, 167.4 55.95, -88.37 -109.17, 14.51 305.07, 151.28 67.69, 15.63 in-out in 9.993 Saltbr-out 6.699 HRD-in -62.96, -52.34 70.46, -10.5 out-out-out SNCooo out-out ActLoopNT-out 12.036 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 112.01 APE9-dihe-na -104.69, -175.56 APE8-dihe-in -119.7, 153.55 APE8-rot-none 999.0 APE67-dihe-in -65.36, -29.34 -115.57, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.198 APE9-dist-out 12.111 None TPO675,TPO686 TPO675,TPO686 XRAY 1.94 0.232 0.253 A 281 261 18 0 0 8 [[525, 791]] 1.0 4js8 OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4JT3A P33981 515 794 857.0 1PH:805 Type1 Inactive DFGin 3.868 14.815 ABAminus DFGAsp-rot-out -98.39, -37.1 -134.23, 157.73 62.48, -79.75 -105.72, 6.6 314.7, 129.31 71.51, 16.26 out-out out 10.738 Saltbr-out 7.684 HRD-in -58.42, -47.48 62.69, -17.16 out-out-out SNCooo out-out ActLoopNT-out 11.512 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.0 APE8-dihe-out 49.94, -124.02 APE8-rot-out 48.54 APE67-dihe-in -61.75, -25.83 -97.12, 5.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.679 None None None XRAY 2.2 0.239 0.251 A 281 254 26 0 0 13 [[525, 791]] 1.0 4jt3 OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4O6LA P33981 515 793 857.0 2QK:1001 Type1 Inactive DFGin 4.407 15.151 ABAminus DFGAsp-rot-out -90.1, -59.73 -114.17, 174.24 72.24, -26.95 -104.1, 2.53 293.21, 159.51 80.72, 3.9 out-out out 10.049 Saltbr-out 6.405 HRD-in -59.12, -54.03 77.12, -18.06 out-out-out SNCooo out-out ActLoopNT-out 12.363 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.49 APE8-rot-out 181.91 APE67-dihe-in -58.9, -26.81 -100.7, 0.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO675,TPO676,SEP677 TPO675,TPO676,SEP677 XRAY 2.38 0.211 0.25 A 281 260 19 0 0 8 [[525, 791]] 1.0 4o6l OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4O6LB P33981 515 793 857.0 2QK:1001 Type1 Inactive DFGin 4.281 15.071 ABAminus DFGAsp-rot-out -86.79, -57.52 -123.5, 173.75 68.12, -25.33 -102.84, -0.16 292.99, 165.07 73.6, 3.12 out-out out 10.29 Saltbr-out 6.205 HRD-in -50.51, -55.85 77.18, -15.75 out-out-out SNCooo out-out ActLoopNT-out 11.325 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 139.99 APE8-dihe-out -73.42, -65.35 APE8-rot-out 60.02 APE67-dihe-in -53.59, -30.18 -99.07, -3.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.391 None TPO675,TPO676,SEP677 TPO675,TPO676,SEP677 XRAY 2.38 0.211 0.25 B 281 256 23 0 0 11 [[525, 791]] 1.0 4o6l OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4ZEGA P33981 516 795 857.0 052:809 Type1 Inactive DFGin 3.84 13.665 ABAminus DFGAsp-rot-out -89.35, -39.59 -147.37, 179.43 68.01, -44.72 -120.68, 6.65 313.22, 129.95 72.3, 17.48 in-in in 9.387 Saltbr-in 2.935 HRD-in -62.37, -56.18 83.02, -11.88 in-out-out SNCioo out-out ActLoopNT-out 12.025 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -10.83 APE8-rot-out 193.46 APE67-dihe-in -54.14, -26.3 -124.62, 9.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.212 0.263 A 281 260 20 0 0 11 [[525, 791]] 1.0 4zeg OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CILA P33981 515 795 857.0 FZR:801 Type1 Inactive DFGin 3.933 14.256 ABAminus DFGAsp-rot-out -117.55, -29.06 -108.82, 151.92 281.76, 18.97 -103.82, 8.49 303.9, 127.51 74.56, 17.84 in-in in 9.438 Saltbr-in 3.365 HRD-in -65.5, -48.3 84.67, -24.88 in-out-out SNCioo out-out ActLoopNT-out 12.9 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 92.45 APE9-dihe-na -62.61, -177.02 APE8-dihe-in -129.03, 162.3 APE8-rot-none 999.0 APE67-dihe-in -61.04, -14.98 -137.19, -4.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.147 APE9-dist-out 12.957 None TPO686 TPO686 XRAY 2.3 0.213 0.246 A 281 265 16 0 0 9 [[525, 791]] 1.0 7cil OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHNA P33981 515 795 857.0 FZL:60801 Type1 Inactive DFGin 4.193 13.806 ABAminus DFGAsp-rot-out -108.25, -28.45 -114.71, 169.67 265.68, 40.29 -123.6, 14.83 311.38, 132.14 76.06, -17.71 in-out in 9.51 Saltbr-out 3.837 HRD-in -65.71, -57.35 92.03, -36.01 out-out-out SNCooo out-out ActLoopNT-out 12.775 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 106.35 APE9-dihe-na -38.75, 152.63 APE8-dihe-in -100.45, 171.07 APE8-rot-none 999.0 APE67-dihe-in -64.61, -12.97 -144.48, -3.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.782 APE9-dist-out 12.373 None TPO675,TPO676,SEP677,TPO686 TPO675,TPO676,SEP677,TPO686 XRAY 2.4 0.209 0.256 A 282 265 16 0 0 4 [[525, 791]] 1.0 7chn OTHER_TTK_HUMAN CAMK 5.8e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHTA P33981 515 794 857.0 FZO:801 Type1 Inactive DFGin 4.45 14.167 ABAminus DFGAsp-rot-in -112.95, -55.33 -89.89, 146.93 213.34, 26.86 -112.72, 5.43 293.25, 164.69 101.6, -45.7 in-in in 9.539 Saltbr-in 3.332 HRD-in -54.87, -60.57 87.7, -19.09 in-out-none SNCion out-none ActLoopNT-out 12.828 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -128.46 APE8-rot-none 999.0 APE67-dihe-in -60.22, -14.09 -125.33, 1.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO675,TPO676,SEP677,TPO686 TPO675,TPO676,SEP677,TPO686 XRAY 2.4 0.214 0.259 A 282 261 19 0 0 7 [[525, 791]] 1.0 7cht OTHER_TTK_HUMAN CAMK 5.8e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CJAA P33981 515 795 857.0 G0U:60801 Type1 Inactive DFGin 4.565 14.38 ABAminus DFGAsp-rot-out -123.14, -50.22 -110.86, 109.05 285.61, -34.5 -73.21, 16.92 303.06, 178.86 54.4, 45.65 in-in in 9.421 Saltbr-in 3.136 HRD-in -56.29, -55.19 87.57, -24.84 in-out-out SNCioo out-out ActLoopNT-out 12.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -106.12 APE9-dihe-na 88.75, 151.9 APE8-dihe-out -119.49, -174.64 APE8-rot-none 999.0 APE67-dihe-in -62.96, -21.71 -126.19, -8.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.69 APE9-dist-out 13.061 None TPO675,TPO676,SEP677,TPO686 TPO675,TPO676,SEP677,TPO686 XRAY 2.49 0.212 0.253 A 283 263 18 0 0 8 [[525, 791]] 1.0 7cja OTHER_TTK_HUMAN CAMK 5.9e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CLHA P33981 516 795 857.0 G5C:801 Type1 Inactive DFGin 4.312 14.634 ABAminus DFGAsp-rot-out -128.87, -39.46 -112.78, 121.46 308.1, -67.96 -81.6, 17.57 300.39, 1.38 66.14, 9.26 out-out out 10.96 Saltbr-out 4.418 HRD-in -65.1, -39.58 41.54, 27.85 out-out-out SNCooo out-out ActLoopNT-out 12.338 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 124.23 APE9-dihe-na -106.52, -148.21 APE8-dihe-in -158.76, 155.6 APE8-rot-none 999.0 APE67-dihe-in -62.14, -23.44 -138.79, 13.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.476 APE9-dist-out 12.451 None TPO675,TPO676,SEP677,TPO686 TPO675,TPO676,SEP677,TPO686 XRAY 2.9 0.21 0.272 A 283 260 20 0 0 9 [[525, 791]] 1.0 7clh OTHER_TTK_HUMAN CAMK 5.9e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4D2SA P33981 513 793 857.0 DYK:1794 Type1 Inactive DFGin 4.273 14.767 ABAminus DFGAsp-rot-out -95.21, -44.96 -135.94, 172.0 60.87, 87.97 -115.3, 6.49 305.25, 149.5 77.48, -1.71 out-out out 10.71 Saltbr-out 6.614 HRD-in -50.94, -45.09 68.46, -25.84 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.79 APE8-rot-out 187.01 APE67-dihe-in -52.43, -42.93 -100.42, -1.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.181 0.221 A 284 249 32 0 0 17 [[525, 791]] 1.0 4d2s OTHER_TTK_HUMAN CAMK 6e-54 189.0 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6TN9A P33981 515 794 857.0 NN5:60901 Type1 Inactive DFGin 4.462 14.473 ABAminus DFGAsp-rot-in -102.75, -43.17 -113.58, 151.32 168.73, 41.4 -116.65, 21.41 306.29, 152.97 57.99, 34.15 in-out in 9.985 Saltbr-out 5.962 HRD-in -27.83, -60.59 74.73, -24.14 out-out-out SNCooo out-out ActLoopNT-out 12.059 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 137.59 APE9-dihe-na -76.58, 147.78 APE8-dihe-in -71.18, 119.63 APE8-rot-out 196.33 APE67-dihe-in -109.27, 4.01 -95.26, 38.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.096 APE9-dist-out 12.459 None None None XRAY 2.6 0.22 0.265 A 294 257 23 0 0 14 [[525, 791]] 1.0 6tn9 OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6TNCA P33981 516 794 857.0 O23:901 Type1 Inactive DFGin 3.822 13.271 ABAminus DFGAsp-rot-out -102.01, -20.32 -149.44, 176.26 71.92, -35.65 -124.03, 9.64 314.66, 123.73 67.72, 11.06 in-in in 9.557 Saltbr-in 2.629 HRD-in -64.18, -55.18 74.7, 4.91 in-out-out SNCioo out-out ActLoopNT-out 11.78 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, -38.28 APE9-dihe-na 92.43, 140.71 APE8-dihe-in -88.61, 139.32 APE8-rot-none 999.0 APE67-dihe-in -66.01, -24.33 -119.33, 14.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.157 APE9-dist-out 12.457 None TPO686 TPO686 XRAY 2.3 0.189 0.236 A 294 259 20 0 0 10 [[525, 791]] 1.0 6tnc OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6N6OA P33981 515 794 857.0 KE7:801 Type1 Inactive DFGin 4.22 15.074 ABAminus DFGAsp-rot-out -105.7, -27.81 -128.43, 140.87 113.64, 999.0 -98.61, 4.99 296.05, 169.82 72.39, 7.89 out-out out 11.0 Saltbr-out 6.776 HRD-in -62.81, -50.74 78.47, -21.46 out-out-none SNCoon out-none ActLoopNT-out 12.065 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.88 APE8-rot-none 999.0 APE67-dihe-in -66.56, -23.16 -93.67, -1.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.202 0.244 A 285 254 26 0 0 16 [[525, 791]] 1.0 6n6o OTHER_TTK_HUMAN CAMK 6.1e-54 189.0 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3GFWA P33981 519 794 857.0 S22:60001 Type1 Inactive DFGin 4.097 15.477 ABAminus DFGAsp-rot-in -102.94, -15.31 -151.43, 156.9 132.24, -84.06 -123.98, 8.09 299.84, 155.88 79.83, 9.4 out-out out 11.334 Saltbr-out 6.864 HRD-in -62.59, -52.13 64.76, 15.17 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -173.82 APE8-dihe-out -84.76, -70.14 APE8-rot-none 999.0 APE67-dihe-in -56.76, -41.42 -66.21, -14.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.954 None None None XRAY 2.74 0.206 0.239 A 313 249 27 0 0 16 [[525, 791]] 1.0 3gfw OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4BHZA P33981 519 794 857.0 Z0B:61797 Type1 Inactive DFGin 3.814 15.15 ABAminus DFGAsp-rot-out -70.44, -40.37 -152.25, 172.63 71.89, -82.24 -109.58, -2.5 303.76, 168.45 78.58, 3.35 out-out out 11.111 Saltbr-out 6.785 HRD-in -65.48, -51.8 72.15, -21.43 out-out-out SNCooo out-out ActLoopNT-out 11.657 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -146.03, 131.66 APE9-dihe-na 99.43, -38.47 APE8-dihe-in -33.12, 126.88 APE8-rot-out 212.76 APE67-dihe-in -59.36, -27.47 -101.37, 0.38 APE12-dist-none 999.0 APE11-dist-out 16.903 APE10-dist-out 14.389 APE9-dist-out 10.561 None None None XRAY 2.85 0.189 0.23 A 313 248 28 0 0 12 [[525, 791]] 1.0 4bhz OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4BI0A P33981 519 794 857.0 Z0W:61797 Type1 Inactive DFGin 3.829 15.141 ABAminus DFGAsp-rot-out -77.7, -43.35 -147.59, 168.95 70.12, -62.01 -104.67, -7.65 305.3, 161.34 84.08, 0.49 out-out out 11.217 Saltbr-out 6.62 HRD-in -66.77, -48.18 66.87, -13.99 out-out-out SNCooo out-out ActLoopNT-out 11.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -172.15, 129.89 APE9-dihe-na 90.95, -5.9 APE8-dihe-in -61.15, 137.1 APE8-rot-out 197.64 APE67-dihe-in -62.02, -25.36 -102.46, -0.21 APE12-dist-none 999.0 APE11-dist-out 17.632 APE10-dist-out 14.507 APE9-dist-out 10.261 None None None XRAY 2.84 0.186 0.224 A 313 251 25 0 0 12 [[525, 791]] 1.0 4bi0 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4BI1A P33981 519 794 857.0 ZO6:61797 Type1 Inactive DFGin 3.952 15.163 ABAminus DFGAsp-rot-out -88.37, -33.85 -141.98, 170.47 70.34, -62.47 -111.95, -2.75 300.7, 163.09 85.15, 1.05 out-out out 11.013 Saltbr-out 6.745 HRD-in -63.61, -47.43 80.83, -10.06 out-out-out SNCooo out-out ActLoopNT-out 11.743 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -95.81, 104.37 APE9-dihe-na 60.87, 40.67 APE8-dihe-in -72.34, 145.56 APE8-rot-out 202.94 APE67-dihe-in -59.86, -24.34 -106.41, -1.69 APE12-dist-none 999.0 APE11-dist-out 16.474 APE10-dist-out 16.277 APE9-dist-out 9.981 None None None XRAY 2.7 0.19 0.228 A 313 249 27 0 0 13 [[525, 791]] 1.0 4bi1 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4BI2A P33981 519 794 857.0 ZO8:61797 Type1 Inactive DFGin 3.62 15.147 ABAminus DFGAsp-rot-out -76.55, -49.66 -141.71, 170.77 56.8, -79.07 -111.27, 13.59 318.83, 139.2 57.0, 30.87 out-out out 11.337 Saltbr-out 7.106 HRD-in -54.6, -40.14 69.57, -18.49 out-out-out SNCooo out-out ActLoopNT-out 11.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -155.03, 149.01 APE9-dihe-na 97.44, -33.31 APE8-dihe-in -41.38, 118.56 APE8-rot-out 207.3 APE67-dihe-in -61.97, -21.49 -89.45, -2.47 APE12-dist-none 999.0 APE11-dist-out 17.105 APE10-dist-out 13.388 APE9-dist-out 10.363 None None None XRAY 3.11 0.195 0.226 A 313 250 26 0 0 13 [[525, 791]] 1.0 4bi2 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4EA P33981 519 794 857.0 4T9:61796 Type1 Inactive DFGin 4.03 15.188 ABAminus DFGAsp-rot-out -90.34, -24.49 -149.19, 168.21 75.48, 89.11 -113.7, 5.3 302.17, 159.25 73.5, 10.67 out-out out 11.101 Saltbr-out 6.861 HRD-in -63.89, -49.54 74.97, -11.85 out-out-out SNCooo out-out ActLoopNT-out 11.831 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooo APE10-dihe-na -179.93, 127.94 APE9-dihe-na 94.59, -22.08 APE8-dihe-in -45.98, 144.24 APE8-rot-none 999.0 APE67-dihe-in -66.59, -18.55 -116.67, 4.35 APE12-dist-none 999.0 APE11-dist-out 17.212 APE10-dist-out 14.589 APE9-dist-out 10.426 None TPO686 TPO686 XRAY 2.6 0.188 0.212 A 313 254 22 0 0 9 [[525, 791]] 1.0 4c4e OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4FA P33981 519 794 857.0 7CE:61799 Type1 Inactive DFGin 4.103 15.216 ABAminus DFGAsp-rot-out -101.62, -18.54 -147.87, 165.66 75.87, -61.07 -113.0, 7.85 297.15, 168.51 67.15, 10.57 out-out out 11.115 Saltbr-out 6.385 HRD-in -61.91, -51.34 67.18, 3.65 out-out-out SNCooo out-out ActLoopNT-out 11.694 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooo APE10-dihe-na -53.1, 141.36 APE9-dihe-na 95.36, -36.89 APE8-dihe-in -36.14, 134.58 APE8-rot-none 999.0 APE67-dihe-in -62.14, -22.97 -109.48, -8.06 APE12-dist-none 999.0 APE11-dist-out 16.949 APE10-dist-out 13.617 APE9-dist-out 10.493 None TPO686 TPO686 XRAY 2.36 0.193 0.222 A 313 251 25 0 0 12 [[525, 791]] 1.0 4c4f OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4GA P33981 519 794 857.0 7RO:61796 Type1 Inactive DFGin 3.951 14.911 ABAminus DFGAsp-rot-out -95.92, -23.51 -152.6, 169.34 81.62, -49.22 -115.91, 15.19 313.37, 131.38 68.79, 7.18 out-out out 10.473 Saltbr-out 6.401 HRD-in -66.58, -56.34 70.86, -10.66 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaono APEdist_nnoo APE10-dihe-na 999.0, -23.29 APE9-dihe-na 75.51, 47.64 APE8-dihe-out -83.97, -34.84 APE8-rot-none 999.0 APE67-dihe-out -67.58, -18.15 68.34, -13.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.742 APE9-dist-out 10.098 None TPO686 TPO686 XRAY 2.65 0.194 0.223 A 313 248 28 0 0 15 [[525, 791]] 1.0 4c4g OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4HA P33981 519 794 857.0 7RO:61795 Type1 Inactive DFGin 3.951 14.788 ABAminus DFGAsp-rot-out -80.93, -53.88 -130.38, 169.34 77.14, -52.84 -111.71, 6.58 311.9, 132.59 84.63, -4.86 out-out out 10.698 Saltbr-out 6.346 HRD-in -63.34, -62.87 84.67, -29.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.95 APE8-rot-out 194.44 APE67-dihe-in -60.4, -21.07 -128.85, -4.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.199 0.241 A 313 245 31 0 0 17 [[525, 791]] 1.0 4c4h OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4IA P33981 519 794 857.0 X20:61795 Type1 Inactive DFGin 4.09 14.912 ABAminus DFGAsp-rot-out -85.8, -40.53 -139.92, 167.53 74.62, -38.64 -117.17, 9.6 306.74, 149.34 84.49, -23.76 out-out out 10.637 Saltbr-out 5.823 HRD-in -64.02, -48.25 79.16, -8.53 out-out-out SNCooo out-out ActLoopNT-out 9.795 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.09 APE8-rot-out 199.19 APE67-dihe-in -59.18, -16.03 -127.61, 0.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.192 0.213 A 313 250 26 0 0 14 [[525, 791]] 1.0 4c4i OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4C4JA P33981 519 794 857.0 X21:61795 Type1 Inactive DFGin 4.404 13.919 ABAminus DFGAsp-rot-in -109.95, -30.18 -116.46, 149.35 174.56, -89.32 -120.89, 12.34 310.2, 113.73 68.77, 1.44 in-in in 9.338 Saltbr-in 2.809 HRD-in -65.51, -59.05 77.98, -5.37 in-out-out SNCioo out-out ActLoopNT-out 12.294 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 21.19 APE9-dihe-na -150.7, 175.28 APE8-dihe-in -114.81, 156.56 APE8-rot-none 999.0 APE67-dihe-in -60.74, -34.36 -112.12, -16.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.848 APE9-dist-out 12.233 None TPO686 TPO686 XRAY 2.5 0.194 0.21 A 313 259 17 0 0 8 [[525, 791]] 1.0 4c4j OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4CV8A P33981 519 794 857.0 3D7:61795 Type1 Inactive DFGin 4.136 15.272 ABAminus DFGAsp-rot-in -101.65, -40.07 -103.15, 134.35 200.8, 3.53 -95.86, -0.86 282.15, 159.92 70.87, 15.07 out-none out 10.379 Saltbr-none 999.0 HRD-in -64.98, -43.27 71.23, -61.83 none-out-out SNCnoo out-out ActLoopNT-out 11.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.12 APE8-dihe-in -68.11, 137.84 APE8-rot-out 188.9 APE67-dihe-in -71.84, -5.33 -100.06, 9.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.53 None None None XRAY 3.0 0.182 0.226 A 313 252 24 0 0 13 [[525, 791]] 1.0 4cv8 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4CV9A P33981 519 794 857.0 W2K:61795 Type1 Inactive DFGin 4.247 15.039 ABAminus DFGAsp-rot-in -101.91, -20.01 -131.88, 149.02 173.2, 51.76 -113.92, 7.67 289.67, 174.21 75.29, -6.63 out-out out 10.207 Saltbr-out 6.351 HRD-in -64.0, -47.62 80.61, -7.87 out-out-out SNCooo out-out ActLoopNT-out 11.667 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 146.4 APE9-dihe-na -66.62, 130.4 APE8-dihe-in -114.41, 114.43 APE8-rot-none 999.0 APE67-dihe-in -66.76, -19.17 -78.46, 1.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.394 APE9-dist-out 11.285 None TPO686 TPO686 XRAY 2.5 0.188 0.232 A 313 251 25 0 0 14 [[525, 791]] 1.0 4cv9 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 4CVAA P33981 519 794 857.0 WBI:61795 Type1 Inactive DFGin 4.137 15.084 ABAminus DFGAsp-rot-in -103.64, -29.1 -121.8, 152.79 161.58, 46.06 -114.4, 8.52 290.87, 175.57 75.57, -11.77 out-out out 10.511 Saltbr-out 6.722 HRD-in -51.45, -55.15 67.0, 6.09 out-out-out SNCooo out-out ActLoopNT-out 11.93 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 131.79 APE9-dihe-na -118.82, 123.96 APE8-dihe-in -82.49, 163.19 APE8-rot-none 999.0 APE67-dihe-in -61.35, -24.47 -128.46, -2.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.162 APE9-dist-out 11.882 None TPO686 TPO686 XRAY 2.5 0.191 0.215 A 313 251 25 0 0 14 [[525, 791]] 1.0 4cva OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP0A P33981 519 795 857.0 AU5:61795 Type1 Inactive DFGin 3.978 15.003 ABAminus DFGAsp-rot-out -96.76, -22.08 -146.7, 164.38 66.52, 82.07 -110.23, 9.55 298.65, 161.95 70.1, 0.89 out-out out 11.03 Saltbr-out 6.05 HRD-in -65.89, -53.49 72.58, -3.97 out-out-out SNCooo out-out ActLoopNT-out 11.633 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooo APE10-dihe-na -63.25, 124.33 APE9-dihe-na 59.83, 23.25 APE8-dihe-in -63.91, 141.71 APE8-rot-none 999.0 APE67-dihe-in -66.96, -16.22 -115.17, -7.01 APE12-dist-none 999.0 APE11-dist-out 16.042 APE10-dist-out 15.643 APE9-dist-out 10.44 None TPO686 TPO686 XRAY 2.15 0.186 0.22 A 313 252 25 0 0 13 [[525, 791]] 1.0 5ap0 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP1A P33981 519 795 857.0 O38:61796 Type1 Inactive DFGin 4.109 14.728 ABAminus DFGAsp-rot-out -89.0, -45.75 -136.45, 170.67 63.33, -82.33 -110.11, 13.99 300.68, 155.11 70.41, 10.72 in-out in 9.663 Saltbr-out 6.106 HRD-in -65.37, -51.62 69.07, -9.73 out-out-out SNCooo out-out ActLoopNT-out 12.212 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 139.28 APE9-dihe-na -84.72, -171.47 APE8-dihe-in -119.66, 146.5 APE8-rot-none 999.0 APE67-dihe-in -60.78, -20.45 -114.29, -8.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.866 APE9-dist-out 12.404 None TPO675,TPO676,SEP677,TPO686 TPO675,TPO676,SEP677,TPO686 XRAY 2.05 0.195 0.211 A 313 268 9 0 0 2 [[525, 791]] 1.0 5ap1 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP2A P33981 519 794 857.0 PWU:61795 Type1 Inactive DFGin 3.691 14.021 ABAminus DFGAsp-rot-out -79.91, -47.41 -141.0, 175.42 79.96, -54.93 -113.38, 7.32 320.57, 109.97 89.57, -32.6 in-in in 9.724 Saltbr-in 3.398 HRD-in -63.17, -34.41 72.38, -58.43 in-out-out SNCioo out-out ActLoopNT-out 12.824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 169.79 APE8-dihe-in -98.15, 169.16 APE8-rot-out 194.76 APE67-dihe-in -65.72, -14.71 -128.84, -2.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.659 None None None XRAY 2.8 0.197 0.254 A 313 253 23 0 0 10 [[525, 791]] 1.0 5ap2 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EHLA P33981 519 796 857.0 0SQ:60901 Type1 Inactive DFGin 4.274 15.158 ABAminus DFGAsp-rot-out -89.17, -26.97 -144.84, 160.15 70.52, 85.82 -105.67, 2.47 304.42, 164.14 76.44, 12.25 out-none out 10.865 Saltbr-none 999.0 HRD-in -63.29, -42.93 60.48, 0.47 none-out-out SNCnoo out-out ActLoopNT-out 11.391 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 165.8 APE9-dihe-na -68.76, 160.5 APE8-dihe-in -124.68, 151.59 APE8-rot-out 183.98 APE67-dihe-in -53.53, -39.03 -99.14, 4.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.241 APE9-dist-out 11.887 None None None XRAY 2.66 0.19 0.219 A 313 254 24 0 0 14 [[525, 791]] 1.0 5ehl OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EHOA P33981 519 794 857.0 5O1:60901 Type1 Inactive DFGin 4.263 15.094 ABAminus DFGAsp-rot-out -83.34, -43.93 -140.36, 165.0 63.33, 77.86 -106.3, 14.68 297.32, 167.25 72.3, 14.29 out-out out 10.168 Saltbr-out 6.539 HRD-in -62.9, -44.14 61.17, -2.98 out-out-out SNCooo out-out ActLoopNT-out 12.187 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 139.96 APE9-dihe-na -95.06, 170.77 APE8-dihe-in -134.87, 145.83 APE8-rot-out 174.69 APE67-dihe-in -61.39, -34.62 -100.96, 10.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.436 APE9-dist-out 11.772 None None None XRAY 2.18 0.191 0.207 A 313 255 21 0 0 9 [[525, 791]] 1.0 5eho OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EHYA P33981 519 794 857.0 5O4:60908 Type1 Inactive DFGin 4.042 15.121 ABAminus DFGAsp-rot-out -87.29, -30.75 -144.51, 167.55 74.41, -84.93 -109.84, 1.63 297.04, 168.45 76.09, -1.53 out-out out 11.216 Saltbr-out 6.35 HRD-in -65.33, -49.5 72.61, -2.8 out-out-out SNCooo out-out ActLoopNT-out 11.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 156.37 APE9-dihe-na -85.3, 71.37 APE8-dihe-in -68.61, 143.92 APE8-rot-out 179.84 APE67-dihe-in -62.19, -35.71 -100.46, 6.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.125 APE9-dist-out 9.939 None None None XRAY 2.26 0.186 0.207 A 313 251 25 0 0 13 [[525, 791]] 1.0 5ehy OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EI2A P33981 516 794 857.0 5O7:901 Type1 Inactive DFGin 3.98 14.476 ABAminus DFGAsp-rot-out -78.73, -52.63 -139.31, 160.64 67.36, -41.64 -92.52, 2.93 318.22, 95.84 89.08, -7.34 out-out out 10.43 Saltbr-out 5.658 HRD-in -63.78, -50.07 70.22, -0.8 out-out-out SNCooo out-out ActLoopNT-out 13.035 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 160.32 APE8-dihe-in -73.87, 160.97 APE8-rot-out 191.53 APE67-dihe-in -64.29, -11.12 -129.83, -10.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.03 None None None XRAY 2.67 0.239 0.295 A 313 256 23 0 0 12 [[525, 791]] 1.0 5ei2 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EI6A P33981 519 794 857.0 5OQ:60901 Type1 Inactive DFGin 3.931 14.347 ABAminus DFGAsp-rot-out -86.7, -33.46 -148.62, 167.92 64.14, -79.61 -109.74, 12.61 310.8, 112.58 71.78, 5.46 in-out in 9.988 Saltbr-out 6.03 HRD-in -61.95, -54.54 69.88, -0.42 out-out-out SNCooo out-out ActLoopNT-out 12.532 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -56.47, 134.25 APE9-dihe-na -152.35, -175.71 APE8-dihe-in -158.59, 132.95 APE8-rot-out 189.02 APE67-dihe-in -61.48, -23.02 -109.15, 7.83 APE12-dist-out 18.709 APE11-dist-out 20.433 APE10-dist-out 18.826 APE9-dist-out 11.962 None None None XRAY 2.01 0.198 0.221 A 313 261 15 0 0 5 [[525, 791]] 1.0 5ei6 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5EI8A P33981 519 753 857.0 5OE:60901 Type1 Inactive DFGin 4.281 14.77 ABAminus DFGAsp-rot-out -81.34, -45.63 -150.03, 174.99 67.77, -66.13 -111.39, 21.62 317.11, 77.36 57.79, 25.49 out-out out 10.356 Saltbr-out 5.362 HRD-in -63.47, -50.78 71.71, -3.86 out-out-out SNCooo out-out ActLoopNT-out 13.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 107.39 APE9-dihe-na -134.97, 110.16 APE8-dihe-in -74.95, 151.91 APE8-rot-out 195.72 APE67-dihe-in -64.93, -13.34 -115.39, 3.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.038 APE9-dist-out 11.805 None None None XRAY 2.17 0.216 0.244 A 313 216 19 0 0 9 [[525, 791]] 1.0 5ei8 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N87A P33981 519 794 857.0 N66:60901 Type1 Inactive DFGin 4.174 15.099 ABAminus DFGAsp-rot-out -88.48, -35.42 -150.02, 176.97 80.51, -50.21 -116.22, 4.15 297.47, 158.19 69.2, 16.91 out-out out 11.112 Saltbr-out 6.463 HRD-in -74.45, -55.5 72.51, 8.91 out-out-out SNCooo out-out ActLoopNT-out 11.459 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooo APE10-dihe-na -86.47, 133.33 APE9-dihe-na 70.41, 9.01 APE8-dihe-in -52.47, 143.66 APE8-rot-none 999.0 APE67-dihe-in -68.74, -15.33 -108.1, -7.79 APE12-dist-none 999.0 APE11-dist-out 18.034 APE10-dist-out 15.202 APE9-dist-out 9.845 None TPO686 TPO686 XRAY 2.29 0.2 0.238 A 313 253 23 0 0 12 [[525, 791]] 1.0 5n87 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP6A P33981 519 794 857.0 PWU:61795 Type1 Inactive DFGin 4.007 14.301 ABAminus DFGAsp-rot-out -114.86, -13.47 -145.86, 158.61 79.69, -27.21 -108.81, 9.51 308.42, 109.78 72.17, 20.89 in-in in 9.906 Saltbr-in 2.963 HRD-in -61.13, -55.8 72.48, -11.9 in-out-out SNCioo out-out ActLoopNT-out 12.997 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -48.78, 124.97 APE9-dihe-na -141.21, -168.37 APE8-dihe-in -169.63, 134.85 APE8-rot-out 190.42 APE67-dihe-in -54.56, -26.33 -104.78, -10.65 APE12-dist-out 18.049 APE11-dist-out 19.9 APE10-dist-out 18.306 APE9-dist-out 11.79 C604W None None XRAY 2.1 0.183 0.209 A 313 259 17 0 0 6 [[525, 791]] 1.0 5ap6 OTHER_TTK_HUMAN CAMK 2.6e-53 187.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP7A P33981 519 794 857.0 SVE:61795 Type1 Inactive DFGin 4.008 15.011 ABAminus DFGAsp-rot-out -75.4, -47.55 -134.63, 175.4 72.62, -31.56 -113.35, 2.93 298.14, 169.12 68.03, 11.08 out-out out 11.216 Saltbr-out 6.288 HRD-in -53.42, -53.82 66.3, 10.85 out-out-out SNCooo out-out ActLoopNT-out 11.476 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -94.63 APE9-dihe-na -108.3, 120.24 APE8-dihe-in -73.36, 151.59 APE8-rot-out 193.39 APE67-dihe-in -46.84, -28.38 -104.91, -10.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.493 APE9-dist-out 10.116 C604W None None XRAY 2.45 0.188 0.234 A 313 253 23 0 0 10 [[525, 791]] 1.0 5ap7 OTHER_TTK_HUMAN CAMK 2.6e-53 187.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5O91A P33981 519 796 857.0 C5N:60901 Type1 Inactive DFGin 3.802 15.016 ABAminus DFGAsp-rot-out -78.15, -40.0 -151.19, 165.46 86.59, -51.41 -106.99, 8.04 304.83, 159.67 51.06, 36.71 out-out out 11.106 Saltbr-out 6.484 HRD-in -71.98, -51.24 56.1, 25.02 out-out-out SNCooo out-out ActLoopNT-out 11.32 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -75.68, 72.2 APE9-dihe-na 66.53, 36.69 APE8-dihe-in -74.19, 134.73 APE8-rot-out 176.75 APE67-dihe-in -60.61, -35.71 -97.24, 8.51 APE12-dist-none 999.0 APE11-dist-out 17.754 APE10-dist-out 18.987 APE9-dist-out 10.206 C604W None None XRAY 3.2 0.214 0.254 A 313 261 17 0 0 6 [[525, 791]] 1.0 5o91 OTHER_TTK_HUMAN CAMK 2.6e-53 187.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6B4WA P33981 515 793 857.0 CQ7:801 Type1 Inactive DFGin 4.794 13.168 ABAminus DFGAsp-rot-in -124.9, -1.56 -141.04, 152.98 125.66, -51.45 -122.68, 8.74 304.31, 73.0 58.44, 34.07 in-none in 9.985 Saltbr-none 999.0 HRD-in -75.92, -62.4 70.1, 24.42 none-out-out SNCnoo out-out ActLoopNT-out 12.641 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 142.31 APE9-dihe-na -91.61, 164.96 APE8-dihe-in -76.84, 169.09 APE8-rot-out 57.53 APE67-dihe-in -71.32, -26.48 -122.98, 9.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.419 APE9-dist-out 13.223 None None None XRAY 2.9 0.194 0.253 A 303 259 20 0 0 9 [[525, 791]] 1.0 6b4w OTHER_TTK_HUMAN CAMK 7.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 2X9EA P33981 515 795 857.0 SVE:1796 Type1 Inactive DFGin 3.523 14.692 ABAminus DFGAsp-rot-out -97.78, -42.88 -144.87, 174.21 82.98, -50.65 -107.75, 2.72 297.55, 168.15 71.6, 31.63 out-out out 11.054 Saltbr-out 5.671 HRD-in -68.71, -48.71 69.68, -10.51 out-out-out SNCooo out-out ActLoopNT-out 11.517 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 32.06 APE8-dihe-in -85.14, 170.49 APE8-rot-out 171.47 APE67-dihe-in -39.15, -60.16 -95.37, -10.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.732 None None None XRAY 3.1 0.215 0.306 A 317 254 27 0 0 15 [[525, 791]] 1.0 2x9e OTHER_TTK_HUMAN CAMK 9e-54 188.5 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3VQUA P33981 516 795 857.0 O22:909 Type1 Inactive DFGin 3.976 14.966 ABAminus DFGAsp-rot-out -81.75, -53.65 -129.74, 172.69 65.49, -89.99 -111.26, 9.8 306.0, 159.19 69.59, 10.96 out-out out 10.342 Saltbr-out 6.054 HRD-out -61.39, 148.14 -116.24, 0.39 out-out-out SNCooo out-out ActLoopNT-out 11.881 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.62 APE8-dihe-in -143.47, 148.23 APE8-rot-out 189.58 APE67-dihe-in -60.98, -38.83 -96.2, 17.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.134 None None None XRAY 2.4 0.251 0.284 A 320 258 22 0 0 10 [[525, 791]] 1.0 3vqu OTHER_TTK_HUMAN CAMK 9.3e-54 188.5 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3WYXA P33981 516 795 857.0 O38:902 Type1 Inactive DFGin 3.839 14.401 ABAminus DFGAsp-rot-out -92.88, -48.98 -138.38, 177.59 60.22, 73.21 -116.03, 10.0 308.72, 129.43 75.11, 2.89 in-out in 9.736 Saltbr-out 5.997 HRD-out -64.04, 113.3 -83.23, 11.65 out-out-out SNCooo out-out ActLoopNT-out 12.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 88.77 APE8-dihe-in -123.04, 145.7 APE8-rot-out 168.34 APE67-dihe-in -60.5, -36.82 -102.78, 9.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.667 None None None XRAY 2.9 0.234 0.273 A 321 258 22 0 0 11 [[525, 791]] 1.0 3wyx OTHER_TTK_HUMAN CAMK 9.4e-54 188.4 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3WYYA P33981 516 795 857.0 O17:901 Type1 Inactive DFGin 3.982 14.418 ABAminus DFGAsp-rot-out -85.96, -42.58 -150.53, 171.45 54.72, 85.69 -108.18, 9.47 313.94, 99.77 63.89, 38.79 in-out in 9.449 Saltbr-out 5.572 HRD-out -71.41, 84.78 -72.82, 23.64 out-out-out SNCooo out-out ActLoopNT-out 12.341 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 114.86 APE8-dihe-in -127.04, 157.36 APE8-rot-out 170.56 APE67-dihe-in -53.64, -55.08 -100.41, 9.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.835 None None None XRAY 3.05 0.229 0.281 A 321 258 22 0 0 11 [[525, 791]] 1.0 3wyy OTHER_TTK_HUMAN CAMK 9.4e-54 188.4 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N7VA P33981 519 794 857.0 8PT:60901 Type1 Inactive DFGin 3.98 14.762 ABAminus DFGAsp-rot-out -96.64, -47.45 -131.22, 170.52 83.78, -42.26 -125.08, -20.32 308.53, 165.4 127.69, 98.89 out-out out 11.117 Saltbr-out 6.023 HRD-in -71.01, -50.2 68.87, 0.08 out-out-out SNCooo out-out ActLoopNT-out 11.99 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -107.54, -172.28 APE9-dihe-na 75.07, -51.21 APE8-dihe-out 34.13, -74.99 APE8-rot-none 999.0 APE67-dihe-out -102.08, -11.37 79.21, 21.03 APE12-dist-out 19.234 APE11-dist-out 17.281 APE10-dist-out 12.443 APE9-dist-out 10.045 None TPO686 TPO686 XRAY 2.52 0.198 0.278 A 313 258 18 0 0 7 [[525, 791]] 1.0 5n7v OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N84A P33981 519 794 857.0 8Q5:60901 Type1 Inactive DFGin 4.166 15.479 ABAminus DFGAsp-rot-out -104.85, -26.96 -154.67, 171.21 86.98, -56.06 -114.47, 1.71 301.25, 166.2 82.91, 8.5 out-out out 11.077 Saltbr-out 6.371 HRD-in -78.13, -54.11 78.05, -3.05 out-out-out SNCooo out-out ActLoopNT-out 11.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -130.46, 173.28 APE9-dihe-na 98.49, -39.6 APE8-dihe-in -54.14, 151.84 APE8-rot-out 188.71 APE67-dihe-in -57.09, -20.86 -123.2, -0.76 APE12-dist-none 999.0 APE11-dist-out 18.806 APE10-dist-out 13.901 APE9-dist-out 10.968 None None None XRAY 2.3 0.207 0.261 A 313 253 23 0 0 12 [[525, 791]] 1.0 5n84 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N93A P33981 519 794 857.0 8QE:60901 Type1 Inactive DFGin 4.019 15.17 ABAminus DFGAsp-rot-out -92.51, -36.83 -150.25, 172.26 72.02, -75.0 -115.14, 5.53 287.99, 174.16 76.77, 9.46 out-out out 10.42 Saltbr-out 6.35 HRD-in -65.77, -53.03 64.47, 9.27 out-out-out SNCooo out-out ActLoopNT-out 11.38 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 137.01 APE9-dihe-na -83.24, -158.05 APE8-dihe-in -135.16, 151.14 APE8-rot-none 999.0 APE67-dihe-in -70.41, -41.42 -123.42, 2.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.772 APE9-dist-out 12.557 None TPO686 TPO686 XRAY 2.1 0.218 0.268 A 313 257 19 0 0 9 [[525, 791]] 1.0 5n93 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5NA0A P33981 519 794 857.0 8QZ:60901 Type1 Inactive DFGin 3.906 14.938 ABAminus DFGAsp-rot-out -90.39, -46.53 -134.15, 168.53 99.39, -61.53 -113.06, 21.64 311.74, 142.6 50.45, 23.25 out-out out 11.26 Saltbr-out 7.066 HRD-in -75.64, -41.45 54.95, 31.21 out-out-out SNCooo out-out ActLoopNT-out 11.345 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 18.56 APE9-dihe-na 98.71, -54.8 APE8-dihe-out 17.03, 101.78 APE8-rot-none 999.0 APE67-dihe-in -55.08, -25.7 -88.73, -14.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.278 APE9-dist-out 11.152 None TPO686 TPO686 XRAY 2.9 0.213 0.271 A 313 251 25 0 0 12 [[525, 791]] 1.0 5na0 OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3HMOA P33981 514 794 857.0 STU:1 Type1 Inactive DFGin 4.034 15.278 ABAminus DFGAsp-rot-out -96.9, -14.35 -154.28, 164.59 63.99, 72.06 -116.14, 11.51 302.21, 156.99 70.91, 11.96 out-out out 11.148 Saltbr-out 6.638 HRD-in -61.3, -53.03 75.35, 1.42 out-out-out SNCooo out-out ActLoopNT-out 11.68 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -169.39 APE9-dihe-na 94.05, 108.89 APE8-dihe-in -96.62, 156.5 APE8-rot-out 54.19 APE67-dihe-in -64.02, -25.79 -101.71, 14.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.123 APE9-dist-out 11.563 None None None XRAY 2.4 0.217 0.261 A 342 257 24 0 0 12 [[525, 791]] 1.0 3hmo OTHER_TTK_HUMAN CAMK 1.2e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3HMPA P33981 516 794 857.0 CX4:1 Type1 Inactive DFGin 3.957 15.102 ABAminus DFGAsp-rot-out -86.78, -27.71 -156.64, 169.65 60.07, 69.54 -114.18, 6.72 299.15, 162.64 67.41, 15.29 out-out out 10.908 Saltbr-out 5.613 HRD-in -69.93, -47.36 72.83, -1.07 out-out-out SNCooo out-out ActLoopNT-out 11.521 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -151.04, 159.23 APE9-dihe-na 115.47, 58.42 APE8-dihe-in -54.12, 148.09 APE8-rot-out 185.33 APE67-dihe-in -65.69, -24.89 -99.64, 11.65 APE12-dist-out 22.456 APE11-dist-out 24.062 APE10-dist-out 19.184 APE9-dist-out 11.382 None None None XRAY 2.3 0.212 0.248 A 342 258 21 0 0 10 [[525, 791]] 1.0 3hmp OTHER_TTK_HUMAN CAMK 1.2e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP3A P33981 519 794 857.0 AU5:61799 Type1 Inactive DFGin 3.765 14.922 ABAminus DFGAsp-rot-out -71.81, -53.86 -135.34, 169.43 63.2, -62.85 -108.89, 4.49 312.31, 146.57 78.37, 4.18 out-out out 10.893 Saltbr-out 6.391 HRD-in -63.22, -46.84 80.03, -8.42 out-out-out SNCooo out-out ActLoopNT-out 11.617 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iooo APE10-dihe-na -73.41, 128.83 APE9-dihe-na 68.53, 48.03 APE8-dihe-in -104.01, 128.39 APE8-rot-none 999.0 APE67-dihe-in -65.18, -22.8 -106.77, -2.15 APE12-dist-in 13.957 APE11-dist-out 16.091 APE10-dist-out 15.009 APE9-dist-out 10.996 S611G TPO686 TPO686 XRAY 2.7 0.192 0.236 A 313 251 25 0 0 12 [[525, 791]] 1.0 5ap3 OTHER_TTK_HUMAN CAMK 2.3e-53 187.3 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP4A P33981 519 794 857.0 O38:61795 Type1 Inactive DFGin 3.893 14.65 ABAminus DFGAsp-rot-out -77.41, -43.92 -141.98, 172.86 78.66, -50.57 -114.54, 10.04 314.02, 147.43 47.66, 52.13 out-out out 10.644 Saltbr-out 5.025 HRD-in -63.63, -47.01 77.61, -5.77 out-out-out SNCooo out-out ActLoopNT-out 11.47 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooo APE10-dihe-na -72.43, 107.58 APE9-dihe-na 57.19, 49.68 APE8-dihe-in -65.83, 162.62 APE8-rot-none 999.0 APE67-dihe-in -58.82, -25.47 -129.9, -17.39 APE12-dist-none 999.0 APE11-dist-out 16.486 APE10-dist-out 16.147 APE9-dist-out 10.04 S611G TPO686 TPO686 XRAY 2.85 0.198 0.226 A 313 254 22 0 0 9 [[525, 791]] 1.0 5ap4 OTHER_TTK_HUMAN CAMK 2.3e-53 187.3 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 2ZMDA P33981 516 795 857.0 537:900 Type1 Inactive DFGin 3.953 15.119 ABAminus DFGAsp-rot-out -86.61, -39.79 -132.74, 164.92 58.08, 50.89 -108.9, 8.43 306.24, 151.22 69.07, 16.45 out-out out 11.283 Saltbr-out 6.751 HRD-in -68.0, -56.19 74.76, 7.11 out-out-out SNCooo out-out ActLoopNT-out 10.431 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -150.77, 128.69 APE9-dihe-na 166.18, -134.04 APE8-dihe-out 62.78, 28.8 APE8-rot-none 999.0 APE67-dihe-in -55.23, -33.98 -72.52, -20.32 APE12-dist-out 22.151 APE11-dist-out 23.348 APE10-dist-out 19.346 APE9-dist-out 12.262 T686A None None XRAY 2.88 0.223 0.261 A 390 259 21 0 0 9 [[525, 791]] 1.0 2zmd OTHER_TTK_HUMAN CAMK 9.3e-53 185.2 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7LQDA P33981 519 795 857.0 YB4:60901,TOE:60907 Type1,Allosteric Inactive DFGin 3.925 14.398 ABAminus DFGAsp-rot-out -86.7, -42.44 -142.37, 165.69 76.87, -10.86 -105.81, -5.45 307.04, 124.04 74.94, 14.22 out-out out 10.954 Saltbr-out 5.963 HRD-in -63.64, -55.17 68.93, 10.11 out-out-out SNCooo out-out ActLoopNT-out 10.155 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -132.63, 166.12 APE9-dihe-na 89.33, 75.78 APE8-dihe-in -67.85, 152.21 APE8-rot-out 180.89 APE67-dihe-in -62.72, -28.33 -111.8, 18.01 APE12-dist-out 23.115 APE11-dist-out 24.259 APE10-dist-out 18.907 APE9-dist-out 11.362 None None None XRAY 1.95 0.2 0.246 A 313 265 12 0 0 1 [[525, 791]] 1.0 7lqd OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5AP5A P33981 519 794 857.0 7RO:61795,1KA:61796 Type1,Type1 Inactive DFGin 3.936 14.93 ABAminus DFGAsp-rot-out -78.19, -51.66 -127.65, 173.7 85.99, -30.94 -118.82, 17.68 309.34, 138.77 57.34, 35.63 out-out out 11.152 Saltbr-out 5.65 HRD-in -63.52, -47.29 78.68, -5.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 112.65 APE8-dihe-in -71.0, 149.52 APE8-rot-out 187.62 APE67-dihe-in -58.84, -28.01 -101.03, -8.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.775 S611G None None XRAY 2.8 0.205 0.246 A 313 248 28 0 0 16 [[525, 791]] 1.0 5ap5 OTHER_TTK_HUMAN CAMK 2.3e-53 187.3 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6TNDA P33981 516 793 857.0 8RH:901 Type1.5_Back Inactive DFGin 3.651 14.037 ABAminus DFGAsp-rot-out -96.05, -33.83 -151.93, -175.24 63.56, 3.54 -130.65, -1.1 295.33, 131.29 74.45, 12.68 in-in in 9.591 Saltbr-in 2.725 HRD-in -64.35, -53.45 78.33, -0.67 in-out-out SNCioo out-out ActLoopNT-out 11.093 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 162.09 APE8-rot-out 36.86 APE67-dihe-in -70.08, -16.5 -127.52, 10.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.58 0.19 0.249 A 294 254 24 0 0 12 [[525, 791]] 1.0 6tnd OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3W1FA P33981 516 795 857.0 1O5:901 Type1.5_Back Inactive DFGin 3.952 14.478 ABAminus DFGAsp-rot-out -90.62, -43.9 -139.59, 171.72 74.93, -33.64 -118.91, 5.4 303.76, 137.67 67.79, 8.35 in-in in 9.904 Saltbr-in 3.265 HRD-out -68.15, 103.17 -73.45, -33.92 in-out-out SNCioo out-out ActLoopNT-out 11.883 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 117.05 APE8-dihe-in -111.17, 166.66 APE8-rot-out 156.69 APE67-dihe-in -56.81, -19.1 -120.87, 15.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.409 None None None XRAY 2.7 0.237 0.277 A 321 259 21 0 0 10 [[525, 791]] 1.0 3w1f OTHER_TTK_HUMAN CAMK 9.4e-54 188.4 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3WZJA P33981 516 794 857.0 O43:901 Type1.5_Back Inactive DFGin 3.731 13.65 ABAminus DFGAsp-rot-out -113.7, -33.36 -129.61, 174.06 82.15, -53.94 -121.04, 7.96 308.49, 98.92 65.98, 3.68 in-in in 9.507 Saltbr-in 2.972 HRD-in -54.5, -49.24 80.42, -18.04 in-out-out SNCioo out-out ActLoopNT-out 11.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 38.01 APE8-dihe-in -53.44, 162.3 APE8-rot-out 173.78 APE67-dihe-in -44.25, -39.42 -139.56, 6.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.111 None None None XRAY 2.75 0.227 0.282 A 321 257 22 0 0 10 [[525, 791]] 1.0 3wzj OTHER_TTK_HUMAN CAMK 9.4e-54 188.4 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3WZKA P33981 516 794 857.0 O23:901 Type1.5_Back Inactive DFGin 3.9 14.124 ABAminus DFGAsp-rot-out -105.12, -8.93 -163.2, -176.41 69.17, -42.43 -130.47, 5.31 306.84, 127.56 66.87, 25.4 in-in in 9.695 Saltbr-in 3.075 HRD-in -65.77, -53.52 80.52, -6.31 in-out-out SNCioo out-out ActLoopNT-out 11.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.25 APE8-dihe-in -163.56, 150.82 APE8-rot-out 169.66 APE67-dihe-in -62.44, -15.14 -116.23, 12.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.505 None None None XRAY 2.3 0.224 0.28 A 321 258 21 0 0 10 [[525, 791]] 1.0 3wzk OTHER_TTK_HUMAN CAMK 9.4e-54 188.4 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5NADA P33981 519 794 857.0 8RH:60901 Type1.5_Back Inactive DFGin 3.678 13.389 ABAminus DFGAsp-rot-out -99.04, -34.18 -143.29, 171.26 57.44, -17.13 -117.88, -6.39 312.7, 119.82 89.46, 5.32 in-in in 9.527 Saltbr-in 3.208 HRD-in -67.44, -48.54 53.7, 23.12 in-out-none SNCion out-none ActLoopNT-out 11.508 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.82 APE8-rot-none 999.0 APE67-dihe-in -61.69, -43.53 -106.91, 27.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO686 TPO686 XRAY 2.8 0.21 0.29 A 313 254 22 0 0 11 [[525, 791]] 1.0 5nad OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 6TNBA P33981 517 794 857.0 8QW:901 Type1.5_Front Inactive DFGin 3.852 15.094 ABAminus DFGAsp-rot-out -120.69, -13.19 -153.82, 168.98 72.21, -21.11 -122.43, 7.93 296.97, 146.25 65.5, 17.91 out-out out 11.011 Saltbr-out 8.542 HRD-in -60.06, -45.03 76.67, -3.67 out-out-out SNCooo out-out ActLoopNT-out 12.114 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 47.02 APE8-dihe-in -74.89, 162.5 APE8-rot-none 999.0 APE67-dihe-in -76.36, -29.64 -145.32, 10.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.114 None TPO686 TPO686 XRAY 2.65 0.215 0.262 A 294 252 26 0 0 15 [[525, 791]] 1.0 6tnb OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N9SA P33981 519 794 857.0 8QW:60901 Type1.5_Front Inactive DFGin 3.866 14.796 ABAminus DFGAsp-rot-out -103.91, -21.18 -148.36, 167.12 78.16, -46.47 -113.73, -1.29 297.53, 126.79 78.88, 15.58 out-out out 10.96 Saltbr-out 9.124 HRD-in -76.88, -53.0 67.73, 3.84 out-out-out SNCooo out-out ActLoopNT-out 11.817 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na 176.56, 127.56 APE9-dihe-na 70.2, 2.51 APE8-dihe-in -61.92, 151.57 APE8-rot-none 999.0 APE67-dihe-in -61.07, -20.0 -114.51, -10.18 APE12-dist-out 19.555 APE11-dist-out 17.191 APE10-dist-out 14.162 APE9-dist-out 10.05 None TPO686 TPO686 XRAY 2.3 0.194 0.245 A 313 257 19 0 0 7 [[525, 791]] 1.0 5n9s OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN AF-P33981-K1A P33981 517 799 857.0 No_ligand No_ligand Inactive DFGin 6.182 14.614 BLAminus DFGAsp-rot-in -126.46, 171.49 63.49, 76.21 197.54, 27.3 -87.18, 16.05 291.59, 77.39 -58.32, -23.29 in-in in 8.948 Saltbr-in 2.778 HRD-in -72.7, -40.65 66.56, -4.75 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -105.04, 133.54 APE9-dihe-na -62.56, -157.84 APE8-dihe-in -72.75, 119.13 APE8-rot-in 304.88 APE67-dihe-in -66.58, -15.24 -44.46, -41.66 APE12-dist-in 10.722 APE11-dist-out 6.335 APE10-dist-out 9.705 APE9-dist-in 4.045 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[525, 791]] 1.0 AF-P33981-K1 OTHER_TTK_HUMAN CAMK 5.9e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN AF-P33981-K3A P33981 517 799 857.0 No_ligand No_ligand Active DFGin 6.301 15.02 BLAminus DFGAsp-rot-in -134.12, 174.57 65.6, 59.77 196.96, 19.31 -77.34, 9.88 287.47, 86.26 -59.03, -34.57 in-in in 8.397 Saltbr-in 2.659 HRD-in -73.18, -39.18 69.58, 0.64 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 143.68 APE9-dihe-na 107.15, 164.37 APE8-dihe-in -93.15, 118.3 APE8-rot-in 301.9 APE67-dihe-in -66.11, -12.59 -45.21, -41.73 APE12-dist-in 9.319 APE11-dist-in 11.123 APE10-dist-in 5.474 APE9-dist-in 3.548 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[525, 791]] 1.0 AF-P33981-K3 OTHER_TTK_HUMAN CAMK 5.9e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 3H9FA P33981 519 794 857.0 92M:60809 Type1 Inactive DFGin 4.831 14.379 BLAplus DFGAsp-rot-out -140.16, 165.23 51.54, 40.51 291.66, -25.25 -99.09, 3.36 73.8, 81.33 -82.43, -174.41 in-none in 9.976 Saltbr-none 999.0 HRD-in -53.0, -59.1 80.34, -10.85 none-out-out SNCnoo out-out ActLoopNT-out 12.144 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.13 APE8-dihe-out -96.95, -14.8 APE8-rot-none 999.0 APE67-dihe-in -58.74, -15.24 -121.28, -11.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.615 None TPO675,TPO676,SEP677 TPO675,TPO676,SEP677 XRAY 2.6 0.21 0.253 A 313 259 17 0 0 7 [[525, 791]] 1.0 3h9f OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.413 14.608 None DFGAsp-rot-in -111.88, -71.82 -63.89, 158.67 216.69, 18.91 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.56 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.264 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.863 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281 260 19 0 0 8 [[525, 791]] 1.0 7chm OTHER_TTK_HUMAN CAMK 5.7e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER UHMK1 UHMK1_HUMAN AF-Q8TAS1-K1A Q8TAS1 15 312 419.0 No_ligand No_ligand Active DFGin 6.527 14.256 BLAminus DFGAsp-rot-in -126.96, 168.43 66.68, 73.02 200.44, 12.08 -84.71, 17.34 289.04, 84.14 -61.88, -28.55 in-in in 8.011 Saltbr-in 2.651 HRD-in -68.2, -43.74 63.98, 2.36 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.53, 157.39 APE9-dihe-na 59.88, 141.6 APE8-dihe-in -72.8, 139.25 APE8-rot-in 292.8 APE67-dihe-inflip 96.53, -23.14 -52.91, 133.86 APE12-dist-in 10.396 APE11-dist-in 8.835 APE10-dist-in 6.66 APE9-dist-in 3.059 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[23, 304]] 1.0 AF-Q8TAS1-K1 OTHER_UHMK1_HUMAN OTHER 1.1e-33 123.3 1 260 260 176 177 178 180 182 54 76 80 155 157 156 158 224 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase Kist
OTHER UHMK1 UHMK1_HUMAN AF-Q8TAS1-K3A Q8TAS1 15 312 419.0 No_ligand No_ligand Active DFGin 6.448 14.128 BLAminus DFGAsp-rot-in -130.23, 168.85 67.43, 68.14 202.35, 6.53 -83.58, 21.04 297.15, 81.83 -66.81, -21.93 in-in in 7.812 Saltbr-in 2.646 HRD-in -67.26, -44.87 67.17, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.0, 157.94 APE9-dihe-na 59.09, 141.88 APE8-dihe-in -73.76, 139.7 APE8-rot-in 296.11 APE67-dihe-inflip 96.97, -17.16 -53.26, 126.65 APE12-dist-in 10.145 APE11-dist-in 8.875 APE10-dist-in 6.576 APE9-dist-in 3.249 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[23, 304]] 1.0 AF-Q8TAS1-K3 OTHER_UHMK1_HUMAN OTHER 1.1e-33 123.3 1 260 260 176 177 178 180 182 54 76 80 155 157 156 158 224 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase Kist
OTHER ULK1 ULK1_HUMAN AF-O75385-K1A O75385 6 286 1050.0 No_ligand No_ligand Active DFGin 6.75 14.79 BLAminus DFGAsp-rot-in -132.29, 173.48 64.23, 61.84 199.45, 22.03 -80.3, 13.99 286.8, 72.12 -59.76, -27.74 in-in in 7.825 Saltbr-in 2.682 HRD-in -78.2, -49.24 68.57, 3.89 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.15, 160.37 APE9-dihe-na 110.09, -166.16 APE8-dihe-in -109.67, 120.79 APE8-rot-in 302.09 APE67-dihe-in -65.9, -17.69 -50.69, -41.26 APE12-dist-in 8.558 APE11-dist-in 11.399 APE10-dist-in 5.669 APE9-dist-in 3.309 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[14, 278]] 1.0 AF-O75385-K1 OTHER_ULK1_HUMAN ULK 2.8e-133 449.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN AF-O75385-K3A O75385 6 286 1050.0 No_ligand No_ligand Active DFGin 6.522 14.712 BLAminus DFGAsp-rot-in -132.89, 173.62 56.04, 72.93 200.63, 13.41 -80.9, 17.31 289.67, 83.41 -58.82, -29.15 in-in in 9.503 Saltbr-in 2.74 HRD-in -83.03, -45.59 66.58, 11.77 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.95, 161.62 APE9-dihe-na 95.93, -165.61 APE8-dihe-in -93.11, 117.67 APE8-rot-in 281.45 APE67-dihe-in -66.15, -20.65 -50.66, -38.59 APE12-dist-in 8.685 APE11-dist-in 11.547 APE10-dist-in 5.801 APE9-dist-in 3.47 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[14, 278]] 1.0 AF-O75385-K3 OTHER_ULK1_HUMAN ULK 2.8e-133 449.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5GA O75385 8 280 1050.0 XBJ:301 Type1 Inactive DFGin 6.518 14.902 BLAminus DFGAsp-rot-out -131.83, 174.56 66.86, 70.15 275.09, 34.38 -93.37, 22.57 283.82, 75.71 -65.98, -26.89 in-in in 7.889 Saltbr-in 2.689 HRD-in -81.46, -52.4 76.6, -1.04 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.29, 165.55 APE9-dihe-na 114.18, -167.61 APE8-dihe-in -118.79, 118.92 APE8-rot-in 309.09 APE67-dihe-in -65.06, -22.59 -45.52, -38.24 APE12-dist-in 8.253 APE11-dist-in 11.272 APE10-dist-in 5.731 APE9-dist-in 3.358 None TPO180 TPO180 XRAY 2.019 0.186 0.227 A 284 266 7 0 0 0 [[14, 278]] 1.0 8p5g OTHER_ULK1_HUMAN ULK 2.9e-133 449.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5GB O75385 8 279 1050.0 XBJ:301 Type1 Inactive DFGin 6.572 15.024 BLAminus DFGAsp-rot-out -135.4, 178.46 64.88, 68.87 302.53, -39.09 -93.18, 23.01 282.11, 76.17 -67.78, -24.97 in-in in 7.972 Saltbr-in 2.739 HRD-in -82.76, -54.3 77.05, -0.87 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.79, 164.27 APE9-dihe-na 111.88, -168.85 APE8-dihe-in -118.82, 119.78 APE8-rot-in 312.92 APE67-dihe-in -62.68, -27.24 -48.44, -36.13 APE12-dist-in 8.236 APE11-dist-in 11.295 APE10-dist-in 5.763 APE9-dist-in 3.35 None TPO180 TPO180 XRAY 2.019 0.186 0.227 B 284 267 5 0 0 0 [[14, 278]] 1.0 8p5g OTHER_ULK1_HUMAN ULK 2.9e-133 449.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5HA O75385 8 280 1050.0 XBJ:301 Type1 Inactive DFGin 6.599 14.92 BLAminus DFGAsp-rot-out -129.29, 176.82 65.78, 70.02 299.67, -20.71 -97.44, 25.05 282.25, 71.0 -64.91, -25.28 in-in in 7.867 Saltbr-in 2.937 HRD-in -82.1, -51.75 78.81, 1.76 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.37, 161.25 APE9-dihe-na 123.23, -169.69 APE8-dihe-in -115.79, 120.35 APE8-rot-in 308.05 APE67-dihe-in -63.93, -23.07 -46.85, -40.87 APE12-dist-in 8.334 APE11-dist-in 11.326 APE10-dist-in 5.728 APE9-dist-in 3.368 R245A,E246A TPO180 TPO180 XRAY 1.941 0.171 0.193 A 284 269 4 0 0 0 [[14, 278]] 1.0 8p5h OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5HB O75385 8 280 1050.0 XBJ:301 Type1 Inactive DFGin 6.554 14.958 BLAminus DFGAsp-rot-out -133.8, 178.84 62.98, 70.34 299.06, -21.67 -95.96, 25.13 283.88, 74.27 -67.78, -23.76 in-in in 7.919 Saltbr-in 2.915 HRD-in -83.94, -53.88 80.46, 0.18 in-in-in SNCiii in-in ActLoopNT-in 2.97 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.13, 162.01 APE9-dihe-na 118.99, -173.25 APE8-dihe-in -115.56, 120.62 APE8-rot-in 314.44 APE67-dihe-in -65.61, -22.87 -47.93, -36.97 APE12-dist-in 8.233 APE11-dist-in 11.212 APE10-dist-in 5.687 APE9-dist-in 3.38 R245A,E246A TPO180 TPO180 XRAY 1.941 0.171 0.193 B 284 269 4 0 0 0 [[14, 278]] 1.0 8p5h OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5IA O75385 8 280 1050.0 WYX:301 Type1 Active DFGin 6.854 15.01 BLAminus DFGAsp-rot-in -132.47, 178.38 59.3, 78.68 192.47, -5.3 -99.79, 21.2 280.63, 74.94 -65.92, -24.22 in-in in 7.743 Saltbr-in 2.738 HRD-in -87.08, -52.42 75.91, 5.56 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.56, 162.92 APE9-dihe-na 114.56, -177.62 APE8-dihe-in -103.24, 119.54 APE8-rot-in 304.75 APE67-dihe-in -70.24, -17.05 -47.06, -38.5 APE12-dist-in 8.311 APE11-dist-in 11.32 APE10-dist-in 5.78 APE9-dist-in 3.305 R245A,E246A TPO180 TPO180 XRAY 1.829 0.167 0.189 A 284 269 4 0 0 0 [[14, 278]] 1.0 8p5i OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5IB O75385 8 280 1050.0 WYX:301 Type1 Inactive DFGin 6.898 14.84 BLAminus DFGAsp-rot-out -129.1, 177.11 61.64, 78.93 253.01, 21.55 -100.83, 21.26 281.6, 74.19 -65.98, -26.25 in-in in 7.667 Saltbr-in 2.721 HRD-in -85.48, -53.24 77.19, 3.22 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.71, 164.36 APE9-dihe-na 118.27, -176.57 APE8-dihe-in -102.53, 119.09 APE8-rot-in 302.14 APE67-dihe-in -71.25, -16.28 -48.97, -37.63 APE12-dist-in 8.255 APE11-dist-in 11.306 APE10-dist-in 5.759 APE9-dist-in 3.292 R245A,E246A TPO180 TPO180 XRAY 1.829 0.167 0.189 B 284 273 0 0 0 0 [[14, 278]] 1.0 8p5i OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5IC O75385 8 280 1050.0 WYX:301 Type1 Inactive DFGin 6.87 14.88 BLAminus DFGAsp-rot-out -130.11, 176.72 61.62, 78.88 254.47, 25.7 -101.16, 21.61 281.23, 74.41 -64.54, -26.89 in-in in 7.718 Saltbr-in 2.698 HRD-in -87.1, -53.42 78.29, 2.85 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.06, 163.91 APE9-dihe-na 118.09, -176.74 APE8-dihe-in -100.74, 119.49 APE8-rot-in 302.38 APE67-dihe-in -71.93, -15.23 -47.78, -38.17 APE12-dist-in 8.303 APE11-dist-in 11.324 APE10-dist-in 5.77 APE9-dist-in 3.288 R245A,E246A TPO180 TPO180 XRAY 1.829 0.167 0.189 C 284 273 0 0 0 0 [[14, 278]] 1.0 8p5i OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5ID O75385 8 279 1050.0 WYX:301 Type1 Active DFGin 6.913 15.049 BLAminus DFGAsp-rot-in -134.0, 178.42 60.12, 80.07 191.23, -5.86 -100.07, 20.83 281.33, 74.97 -65.11, -28.02 in-in in 7.826 Saltbr-in 2.744 HRD-in -85.08, -53.74 77.56, 2.53 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.45, 165.99 APE9-dihe-na 114.39, -178.66 APE8-dihe-in -101.96, 120.18 APE8-rot-in 308.2 APE67-dihe-in -70.62, -15.62 -46.32, -39.81 APE12-dist-in 8.298 APE11-dist-in 11.317 APE10-dist-in 5.775 APE9-dist-in 3.314 R245A,E246A TPO180 TPO180 XRAY 1.829 0.167 0.189 D 284 267 5 0 0 0 [[14, 278]] 1.0 8p5i OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5JA O75385 8 279 1050.0 WYT:301 Type1 Inactive DFGin 6.929 15.113 BLAminus DFGAsp-rot-out -123.22, 172.29 71.25, 69.92 254.82, 65.58 -94.91, 19.03 280.38, 75.34 -60.01, -29.74 in-in in 7.775 Saltbr-in 2.752 HRD-in -81.28, -54.31 77.31, 5.54 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.68, 170.9 APE9-dihe-na 108.58, -171.46 APE8-dihe-in -115.29, 120.62 APE8-rot-in 310.38 APE67-dihe-in -70.4, -14.4 -46.67, -41.95 APE12-dist-in 8.26 APE11-dist-in 11.2 APE10-dist-in 5.625 APE9-dist-in 3.294 R245A,E246A TPO180 TPO180 XRAY 2.164 0.169 0.2 A 284 269 3 0 0 0 [[14, 278]] 1.0 8p5j OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5JB O75385 8 279 1050.0 WYT:301 Type1 Inactive DFGin 6.873 15.129 BLAminus DFGAsp-rot-out -128.23, 173.61 71.21, 70.61 265.05, 68.29 -94.84, 16.73 280.63, 75.2 -62.56, -26.17 in-in in 7.823 Saltbr-in 3.458 HRD-in -81.19, -51.76 75.8, 5.32 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.51, 168.59 APE9-dihe-na 108.53, -172.34 APE8-dihe-in -114.1, 121.28 APE8-rot-in 312.18 APE67-dihe-in -61.85, -25.89 -45.3, -41.45 APE12-dist-in 8.256 APE11-dist-in 11.23 APE10-dist-in 5.673 APE9-dist-in 3.329 R245A,E246A TPO180 TPO180 XRAY 2.164 0.169 0.2 B 284 268 4 0 0 0 [[14, 278]] 1.0 8p5j OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5KA O75385 8 280 1050.0 HVH:301 Type1 Active DFGin 6.742 14.715 BLAminus DFGAsp-rot-in -123.72, 171.89 67.88, 80.62 195.39, -0.47 -99.38, 24.26 281.35, 73.47 -68.25, -24.9 in-in in 7.814 Saltbr-in 2.536 HRD-in -85.41, -56.74 78.3, 4.91 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.74, 164.59 APE9-dihe-na 116.06, -168.25 APE8-dihe-in -110.24, 117.6 APE8-rot-in 317.58 APE67-dihe-in -67.16, -21.54 -47.41, -36.22 APE12-dist-in 8.227 APE11-dist-in 11.327 APE10-dist-in 5.788 APE9-dist-in 3.506 R245A,E246A TPO180 TPO180 XRAY 2.209 0.178 0.204 A 284 269 4 0 0 0 [[14, 278]] 1.0 8p5k OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5KB O75385 8 280 1050.0 HVH:301 Type1 Active DFGin 6.832 14.645 BLAminus DFGAsp-rot-in -118.25, 167.49 70.32, 81.29 194.53, -2.15 -97.66, 23.62 280.74, 75.72 -68.22, -25.42 in-in in 7.845 Saltbr-in 2.59 HRD-in -86.1, -55.98 78.95, 4.51 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.89, 164.94 APE9-dihe-na 116.49, -167.93 APE8-dihe-in -110.43, 117.75 APE8-rot-in 314.49 APE67-dihe-in -69.34, -17.99 -48.03, -37.42 APE12-dist-in 8.241 APE11-dist-in 11.277 APE10-dist-in 5.692 APE9-dist-in 3.445 R245A,E246A TPO180 TPO180 XRAY 2.209 0.178 0.204 B 284 273 0 0 0 0 [[14, 278]] 1.0 8p5k OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5KC O75385 8 279 1050.0 HVH:301 Type1 Active DFGin 6.713 14.751 BLAminus DFGAsp-rot-in -125.18, 172.47 67.68, 80.65 195.49, -3.27 -98.81, 22.5 282.68, 72.32 -64.77, -26.91 in-in in 7.846 Saltbr-in 2.54 HRD-in -86.6, -57.28 77.88, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.67, 163.88 APE9-dihe-na 115.6, -168.07 APE8-dihe-in -110.3, 117.1 APE8-rot-in 314.79 APE67-dihe-in -66.76, -21.22 -46.82, -37.18 APE12-dist-in 8.295 APE11-dist-in 11.352 APE10-dist-in 5.832 APE9-dist-in 3.485 R245A,E246A TPO180 TPO180 XRAY 2.209 0.178 0.204 C 284 268 4 0 0 0 [[14, 278]] 1.0 8p5k OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5KD O75385 8 280 1050.0 HVH:301 Type1 Active DFGin 6.802 14.677 BLAminus DFGAsp-rot-in -119.07, 170.02 68.93, 81.98 193.97, -1.18 -99.32, 23.81 281.33, 73.01 -66.85, -25.82 in-in in 7.814 Saltbr-in 2.582 HRD-in -85.03, -56.32 80.54, 2.71 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.73, 164.82 APE9-dihe-na 116.42, -169.33 APE8-dihe-in -108.6, 117.69 APE8-rot-in 311.41 APE67-dihe-in -68.54, -18.87 -48.6, -37.15 APE12-dist-in 8.284 APE11-dist-in 11.289 APE10-dist-in 5.739 APE9-dist-in 3.436 R245A,E246A TPO180 TPO180 XRAY 2.209 0.178 0.204 D 284 273 0 0 0 0 [[14, 278]] 1.0 8p5k OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5LA O75385 8 280 1050.0 1FV:301 Type1 Active DFGin 6.691 14.736 BLAminus DFGAsp-rot-in -130.7, 173.1 66.26, 75.49 201.5, -7.42 -95.68, 23.13 285.9, 73.72 -68.55, -22.72 in-in in 7.814 Saltbr-in 2.756 HRD-in -85.36, -54.49 79.18, 1.25 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.52, 165.44 APE9-dihe-na 116.33, -164.58 APE8-dihe-in -112.52, 114.53 APE8-rot-in 303.51 APE67-dihe-in -69.54, -12.23 -47.78, -40.31 APE12-dist-in 8.3 APE11-dist-in 11.345 APE10-dist-in 5.742 APE9-dist-in 3.397 R245A,E246A TPO180 TPO180 XRAY 1.836 0.177 0.211 A 284 269 4 0 0 0 [[14, 278]] 1.0 8p5l OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8P5LB O75385 8 280 1050.0 1FV:301 Type1 Active DFGin 6.818 14.743 BLAminus DFGAsp-rot-in -128.36, 176.27 63.29, 81.81 192.99, -1.3 -99.8, 24.69 280.4, 77.18 -68.83, -23.52 in-in in 7.88 Saltbr-in 2.715 HRD-in -87.29, -51.48 77.39, 4.75 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.84, 169.11 APE9-dihe-na 108.79, -170.64 APE8-dihe-in -109.64, 119.57 APE8-rot-in 314.4 APE67-dihe-in -60.04, -24.68 -48.59, -40.67 APE12-dist-in 8.338 APE11-dist-in 11.342 APE10-dist-in 5.754 APE9-dist-in 3.347 R245A,E246A TPO180 TPO180 XRAY 1.836 0.177 0.211 B 284 269 4 0 0 0 [[14, 278]] 1.0 8p5l OTHER_ULK1_HUMAN ULK 1.8e-132 446.4 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 6MNHA O75385 8 290 1050.0 JVD:301 Type1 Inactive DFGin 7.316 14.788 BLAminus DFGAsp-rot-in -119.83, 176.95 75.54, 68.32 208.74, 24.45 -100.42, 16.13 276.83, 81.09 -62.83, -29.58 in-in in 7.911 Saltbr-in 2.703 HRD-in -73.32, -50.94 83.28, -10.25 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -139.79, 148.64 APE9-dihe-na -175.19, -114.4 APE8-dihe-in -124.46, 95.49 APE8-rot-in 299.35 APE67-dihe-in -63.2, -21.88 -50.81, -27.59 APE12-dist-in 9.348 APE11-dist-out 6.762 APE10-dist-out 9.641 APE9-dist-out 6.853 S195A,S224A SEP87 SEP87,CSO182 XRAY 1.73 0.19 0.228 A 287 267 16 0 0 7 [[14, 278]] 1.0 6mnh OTHER_ULK1_HUMAN ULK 1.1e-132 447.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8SV9A O75385 8 281 1050.0 WXH:301 Type1 Active DFGin 6.94 14.751 BLAminus DFGAsp-rot-in -126.52, 178.79 60.93, 80.98 208.8, -4.08 -104.21, 19.42 281.54, 74.44 -66.53, -27.97 in-in in 7.875 Saltbr-in 2.653 HRD-in -85.13, -55.58 75.51, 7.4 in-in-in SNCiii in-in ActLoopNT-in 3.088 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.27, 171.5 APE9-dihe-na 101.37, -176.67 APE8-dihe-in -95.03, 127.96 APE8-rot-in 279.07 APE67-dihe-in -64.45, -23.77 -53.92, -38.4 APE12-dist-in 8.295 APE11-dist-in 11.132 APE10-dist-in 5.61 APE9-dist-in 3.476 E37A,K38A SEP87,TPO180 SEP87,TPO180 XRAY 2.3 0.212 0.247 A 283 274 0 0 0 0 [[14, 278]] 1.0 8sv9 OTHER_ULK1_HUMAN ULK 2e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 8SV9B O75385 8 281 1050.0 WXH:301 Type1 Active DFGin 6.785 14.614 BLAminus DFGAsp-rot-in -125.39, 179.44 61.46, 77.34 198.73, 6.68 -99.69, 22.49 284.79, 77.46 -66.39, -27.05 in-in in 7.676 Saltbr-in 2.589 HRD-in -86.07, -52.27 71.86, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.77, 164.69 APE9-dihe-na 107.1, -175.83 APE8-dihe-in -100.66, 125.95 APE8-rot-in 306.98 APE67-dihe-in -62.72, -18.2 -53.9, -41.51 APE12-dist-in 8.292 APE11-dist-in 11.216 APE10-dist-in 5.68 APE9-dist-in 3.497 E37A,K38A SEP87,TPO180 SEP87,TPO180 XRAY 2.3 0.212 0.247 B 283 274 0 0 0 0 [[14, 278]] 1.0 8sv9 OTHER_ULK1_HUMAN ULK 2e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 4WNOA O75385 8 280 1050.0 3RF:401 Type1 Inactive DFGin 6.889 14.949 BLAminus DFGAsp-rot-out -117.94, 169.26 64.81, 74.6 293.31, -7.42 -94.14, 20.86 282.18, 71.59 -63.55, -24.11 in-in in 7.662 Saltbr-in 2.77 HRD-in -82.57, -51.36 80.06, -2.07 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.03, 162.62 APE9-dihe-na 120.91, -162.5 APE8-dihe-in -119.54, 124.2 APE8-rot-in 305.96 APE67-dihe-in -67.71, -19.19 -53.63, -37.75 APE12-dist-in 8.214 APE11-dist-in 11.212 APE10-dist-in 5.675 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.56 0.18 0.208 A 287 273 0 0 0 0 [[14, 278]] 1.0 4wno OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 4WNPA O75385 7 280 1050.0 3RJ:303 Type1 Active DFGin 6.995 15.046 BLAminus DFGAsp-rot-in -119.62, 166.82 69.01, 82.0 204.28, -17.6 -103.27, 16.67 279.97, 77.71 -62.76, -23.51 in-in in 7.94 Saltbr-in 2.499 HRD-in -81.76, -53.0 76.62, 2.2 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.2, 168.11 APE9-dihe-na 114.36, -176.46 APE8-dihe-in -108.19, 123.53 APE8-rot-in 302.32 APE67-dihe-in -68.78, -16.2 -37.83, -49.18 APE12-dist-in 8.382 APE11-dist-in 11.285 APE10-dist-in 5.845 APE9-dist-in 3.283 E37A,K38A TPO180 TPO180 XRAY 1.88 0.194 0.226 A 287 274 0 0 0 0 [[14, 278]] 1.0 4wnp OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 4WNPB O75385 8 280 1050.0 3RJ:401 Type1 Active DFGin 6.915 14.933 BLAminus DFGAsp-rot-in -122.94, 171.73 60.52, 83.99 193.35, -7.67 -103.78, 20.71 282.68, 81.42 -62.77, -26.15 in-in in 7.934 Saltbr-in 2.715 HRD-in -83.74, -50.92 75.53, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.85, 169.04 APE9-dihe-na 112.7, -177.08 APE8-dihe-in -104.59, 125.84 APE8-rot-in 311.45 APE67-dihe-in -71.84, -13.3 -49.94, -37.17 APE12-dist-in 8.233 APE11-dist-in 11.335 APE10-dist-in 5.827 APE9-dist-in 3.334 E37A,K38A TPO180 TPO180 XRAY 1.88 0.194 0.226 B 287 273 0 0 0 0 [[14, 278]] 1.0 4wnp OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 4WNPC O75385 8 279 1050.0 3RJ:401 Type1 Active DFGin 6.841 14.843 BLAminus DFGAsp-rot-in -127.5, 176.17 60.94, 81.17 200.65, -18.4 -99.91, 16.61 282.52, 78.24 -54.0, -30.6 in-in in 7.787 Saltbr-in 2.411 HRD-in -84.07, -52.11 74.67, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.28, 173.48 APE9-dihe-na 103.65, -175.78 APE8-dihe-in -104.7, 127.64 APE8-rot-in 300.66 APE67-dihe-in -75.42, -10.53 -35.46, -48.63 APE12-dist-in 8.18 APE11-dist-in 10.99 APE10-dist-in 5.559 APE9-dist-in 3.351 E37A,K38A TPO180 TPO180 XRAY 1.88 0.194 0.226 C 287 272 0 0 0 0 [[14, 278]] 1.0 4wnp OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 4WNPD O75385 8 280 1050.0 3RJ:401 Type1 Active DFGin 6.797 14.879 BLAminus DFGAsp-rot-in -124.34, 171.93 65.59, 80.61 195.12, -6.37 -102.54, 20.8 278.75, 73.99 -65.45, -24.99 in-in in 7.771 Saltbr-in 2.487 HRD-in -82.27, -50.67 73.86, 1.16 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.24, 170.11 APE9-dihe-na 114.27, -170.33 APE8-dihe-in -112.74, 130.56 APE8-rot-in 315.18 APE67-dihe-in -73.84, -10.36 -37.5, -50.28 APE12-dist-in 8.28 APE11-dist-in 11.259 APE10-dist-in 5.832 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.88 0.194 0.226 D 287 273 0 0 0 0 [[14, 278]] 1.0 4wnp OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 5CI7A O75385 3 279 1050.0 51W:401 Type1 Inactive DFGin 6.835 14.779 BLAminus DFGAsp-rot-out -127.47, -179.95 57.19, 69.39 293.88, -17.46 -92.09, 19.84 281.01, 73.24 -64.77, -26.59 in-in in 7.556 Saltbr-in 2.786 HRD-in -82.16, -51.47 79.26, -11.8 in-in-in SNCiii in-in ActLoopNT-in 2.994 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.51, 167.9 APE9-dihe-na 120.68, -160.81 APE8-dihe-in -121.65, 123.28 APE8-rot-in 296.91 APE67-dihe-in -74.8, -11.61 -53.26, -37.44 APE12-dist-in 8.336 APE11-dist-in 11.476 APE10-dist-in 5.882 APE9-dist-in 3.47 E37A,K38A TPO180 TPO180 XRAY 1.74 0.171 0.207 A 287 277 0 0 0 0 [[14, 278]] 1.0 5ci7 OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 6QASA O75385 8 281 1050.0 34W:318 Type1 Inactive DFGin 6.73 14.82 BLAminus DFGAsp-rot-in -123.63, 171.57 69.53, 75.17 190.62, 5.35 -96.26, 16.89 281.93, 76.2 -68.0, -21.45 in-in in 7.582 Saltbr-in 2.674 HRD-in -81.87, -55.38 77.89, 3.62 in-in-out SNCiio in-out ActLoopNT-in 2.849 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.04, 151.58 APE9-dihe-na 104.88, -171.7 APE8-dihe-in -104.31, 123.2 APE8-rot-out 183.78 APE67-dihe-in -70.87, -16.9 -48.83, -38.25 APE12-dist-in 8.032 APE11-dist-in 10.8 APE10-dist-in 5.619 APE9-dist-in 3.301 None SEP87,TPO180 SEP87,TPO180 XRAY 1.75 0.171 0.197 A 287 274 0 0 0 0 [[14, 278]] 1.0 6qas OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 6QASB O75385 8 280 1050.0 34W:315,34W:316 Type1,Allosteric Inactive DFGin 6.775 14.826 BLAminus DFGAsp-rot-in -126.72, 176.42 67.25, 75.49 194.32, 1.7 -100.21, 16.56 281.95, 78.82 -63.24, -25.02 in-in in 7.582 Saltbr-in 2.74 HRD-in -79.7, -52.04 77.45, 0.99 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.43, 147.7 APE9-dihe-na 105.19, -164.06 APE8-dihe-in -107.12, 129.65 APE8-rot-out 181.42 APE67-dihe-in -73.23, -12.27 -46.71, -45.1 APE12-dist-in 8.219 APE11-dist-in 10.716 APE10-dist-in 5.567 APE9-dist-in 3.316 None SEP87,TPO180 SEP87,TPO180 XRAY 1.75 0.171 0.197 B 287 273 0 0 0 0 [[14, 278]] 1.0 6qas OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK1 ULK1_HUMAN 9F32A O75385 8 282 1050.0 A1H9M:301 Type1 Inactive None 999.0 999.0 None DFGAsp-rot-out -117.88, 162.03 75.88, 10.45 261.63, -4.86 -74.55, 999.0 999.0, 999.0 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.21, -59.08 89.02, -22.91 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -146.7 APE9-dihe-na 77.14, -27.82 APE8-dihe-in -75.49, 116.61 APE8-rot-out 64.92 APE67-dihe-in -56.15, -22.23 -91.93, -3.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.331 None None None XRAY 2.1 0.223 0.254 A 285 240 35 0 0 15 [[14, 278]] 1.0 9f32 OTHER_ULK1_HUMAN ULK 3e-133 449.0 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
OTHER ULK2 ULK2_HUMAN AF-Q8IYT8-K1A Q8IYT8 1 279 1036.0 No_ligand No_ligand Active DFGin 6.788 14.73 BLAminus DFGAsp-rot-in -130.84, 171.88 65.56, 64.35 199.97, 19.35 -83.14, 15.59 286.88, 74.88 -61.05, -28.69 in-in in 7.743 Saltbr-in 2.666 HRD-in -80.07, -47.97 65.91, 14.51 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.92, 163.4 APE9-dihe-na 105.11, -169.87 APE8-dihe-in -105.53, 123.43 APE8-rot-in 302.04 APE67-dihe-in -67.37, -17.52 -50.54, -41.33 APE12-dist-in 8.42 APE11-dist-in 11.266 APE10-dist-in 5.551 APE9-dist-in 3.246 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[7, 271]] 1.0 AF-Q8IYT8-K1 OTHER_ULK2_HUMAN ULK 1.9e-132 446.4 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN AF-Q8IYT8-K3A Q8IYT8 1 279 1036.0 No_ligand No_ligand Active DFGin 6.365 14.739 BLAminus DFGAsp-rot-in -133.9711, 173.6037 57.058, 70.7748 199.3028, 18.482 -80.6559, 17.1681 290.4842, 81.7235 -59.8296, -28.1276 in-in in 9.443 Saltbr-in 2.748 HRD-in -79.5058, -45.3399 67.0738, 10.3733 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.7009, 158.9895 APE9-dihe-na 100.9043, -160.2332 APE8-dihe-in -103.9851, 114.8071 APE8-rot-in 301.1878 APE67-dihe-in -65.7731, -17.9228 -49.3346, -42.8742 APE12-dist-in 8.898 APE11-dist-in 11.505 APE10-dist-in 5.773 APE9-dist-in 3.333 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[7, 271]] 1.0 AF-Q8IYT8-K3 OTHER_ULK2_HUMAN ULK 1.9e-132 446.4 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QATA Q8IYT8 1 274 1036.0 FE7:60301 Type1 Inactive DFGin 6.462 15.61 BLAminus DFGAsp-rot-in -133.24, 178.22 66.63, 82.95 188.19, 7.91 -98.98, 24.8 291.52, 83.42 -49.24, -44.8 out-out out 10.255 Saltbr-out 4.723 HRD-in -68.63, -61.34 89.55, -16.09 out-in-none SNCoin in-none ActLoopNT-in 2.888 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.47, -35.78 999.0, 42.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.77 0.22 0.262 A 280 259 15 0 0 10 [[7, 271]] 1.0 6qat OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QATB Q8IYT8 1 274 1036.0 FE7:60301 Type1 Inactive DFGin 6.295 15.468 BLAminus DFGAsp-rot-in -136.55, 177.83 66.4, 84.24 185.74, -0.6 -99.05, 24.94 291.91, 83.9 -51.31, -42.43 out-out out 10.233 Saltbr-out 4.318 HRD-in -66.57, -63.69 87.34, -10.67 out-in-none SNCoin in-none ActLoopNT-in 2.876 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.0, -36.46 999.0, 45.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.77 0.22 0.262 B 280 241 33 0 0 10 [[7, 271]] 1.0 6qat OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QATC Q8IYT8 1 273 1036.0 FE7:60301 Type1 Inactive DFGin 6.365 15.469 BLAminus DFGAsp-rot-in -134.17, 177.16 66.29, 83.52 186.89, 6.08 -100.0, 24.59 291.49, 83.59 -46.54, -45.27 out-out out 10.11 Saltbr-out 3.655 HRD-in -66.74, -63.8 88.67, -12.49 out-in-none SNCoin in-none ActLoopNT-in 2.893 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.01, -38.73 999.0, 43.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.77 0.22 0.262 C 280 256 17 0 0 10 [[7, 271]] 1.0 6qat OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QATD Q8IYT8 1 270 1036.0 FE7:60301 Type1 Inactive DFGin 6.384 15.148 BLAminus DFGAsp-rot-in -134.6, 177.83 67.03, 84.79 188.03, 6.61 -100.02, 24.06 292.3, 83.96 -47.26, -46.67 in-out in 9.8 Saltbr-out 3.604 HRD-in -66.96, -62.82 90.18, -13.81 out-in-none SNCoin in-none ActLoopNT-in 2.883 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -58.65, -35.65 999.0, 40.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.77 0.22 0.262 D 280 252 19 0 0 12 [[7, 271]] 1.0 6qat OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAUA Q8IYT8 1 275 1036.0 1FV:60301 Type1 Inactive DFGin 6.745 14.665 BLAminus DFGAsp-rot-in -137.48, 169.26 64.53, 85.44 190.66, 5.21 -99.8, 17.43 283.47, 82.36 -55.35, -30.44 in-in in 8.312 Saltbr-in 2.623 HRD-in -85.97, -51.92 81.16, -8.9 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -109.43, 19.17 APE9-dihe-na 62.87, -148.23 APE8-dihe-in -60.3, 131.56 APE8-rot-out 183.31 APE67-dihe-in -70.13, -21.92 -94.64, 21.71 APE12-dist-out 25.388 APE11-dist-out 22.89 APE10-dist-out 24.013 APE9-dist-out 31.49 None None None XRAY 2.48 0.198 0.237 A 280 275 0 0 0 0 [[7, 271]] 1.0 6qau OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAUB Q8IYT8 1 274 1036.0 1FV:60301 Type1 None DFGin 6.69 14.941 BLAminus DFGAsp-rot-in -136.25, 168.35 65.98, 84.31 191.46, -2.27 -99.13, 17.87 284.11, 83.42 -56.69, -27.27 in-in in 9.16 Saltbr-in 2.803 HRD-in -82.01, -52.27 83.93, -11.12 in-in-none SNCiin in-none ActLoopNT-in 3.005 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.13, -14.46 999.0, 14.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.48 0.198 0.237 B 280 264 10 0 0 10 [[7, 271]] 1.0 6qau OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAUC Q8IYT8 1 273 1036.0 1FV:60301 Type1 Inactive DFGin 6.628 14.918 BLAminus DFGAsp-rot-in -137.1, 168.11 66.1, 84.56 192.62, -6.02 -99.51, 15.17 283.6, 83.23 -57.29, -27.4 in-in in 8.822 Saltbr-in 2.681 HRD-in -83.07, -52.46 84.37, -11.94 in-in-out SNCiio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.21 APE8-rot-none 999.0 APE67-dihe-out -72.59, -14.84 -81.65, 73.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.48 0.198 0.237 C 280 248 25 0 0 9 [[7, 271]] 1.0 6qau OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAVA Q8IYT8 1 272 1036.0 HVH:60301 Type1 Inactive DFGin 6.895 14.794 BLAminus DFGAsp-rot-in -136.07, 175.86 59.0, 79.31 192.6, 8.91 -100.74, 24.59 281.31, 80.55 -72.23, -18.38 in-in in 8.441 Saltbr-in 2.575 HRD-in -77.65, -50.94 79.92, -5.53 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.85, -11.39 APE9-dihe-na 88.19, -118.13 APE8-dihe-in -73.63, 117.08 APE8-rot-out 64.88 APE67-dihe-in -77.18, -0.81 -92.4, 11.55 APE12-dist-out 23.023 APE11-dist-out 21.947 APE10-dist-out 23.351 APE9-dist-out 30.816 None None None XRAY 2.05 0.197 0.231 A 280 272 0 0 0 0 [[7, 271]] 1.0 6qav OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAVB Q8IYT8 1 273 1036.0 HVH:60301 Type1 Inactive DFGin 7.061 14.655 BLAminus DFGAsp-rot-in -135.17, 175.67 62.66, 80.39 188.5, 9.29 -98.86, 22.32 282.31, 83.65 -72.66, -14.72 in-in in 8.382 Saltbr-in 2.583 HRD-in -75.58, -48.78 79.52, -6.77 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -71.93, -46.22 APE9-dihe-na 85.86, -42.01 APE8-dihe-in -100.08, 98.49 APE8-rot-in 292.6 APE67-dihe-in -80.76, -15.63 -91.08, 15.77 APE12-dist-out 23.348 APE11-dist-out 22.422 APE10-dist-out 24.724 APE9-dist-out 30.941 None None None XRAY 2.05 0.197 0.231 B 280 268 5 0 0 0 [[7, 271]] 1.0 6qav OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAVC Q8IYT8 1 275 1036.0 HVH:60301 Type1 Inactive DFGin 7.117 14.543 BLAminus DFGAsp-rot-in -132.86, 176.04 62.38, 80.99 187.99, 7.92 -99.96, 22.04 285.71, 82.2 -76.35, -13.64 in-in in 8.396 Saltbr-in 2.591 HRD-in -68.48, -49.38 78.19, -5.22 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -129.86, 69.41 APE9-dihe-na 85.66, -124.09 APE8-dihe-in -165.83, 113.01 APE8-rot-out 64.12 APE67-dihe-out -75.56, -17.76 -68.81, 71.29 APE12-dist-out 23.28 APE11-dist-out 21.786 APE10-dist-out 22.495 APE9-dist-out 29.538 None None None XRAY 2.05 0.197 0.231 C 280 275 0 0 0 0 [[7, 271]] 1.0 6qav OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6QAVD Q8IYT8 1 272 1036.0 HVH:60301 Type1 Inactive DFGin 6.923 14.782 BLAminus DFGAsp-rot-in -132.84, 173.6 63.23, 78.67 191.18, 9.78 -99.31, 24.31 282.87, 81.31 -74.13, -17.11 in-in in 8.414 Saltbr-in 2.554 HRD-in -73.21, -47.78 78.42, -7.11 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -95.12, -56.26 APE9-dihe-na 125.02, -33.45 APE8-dihe-in -108.38, 101.68 APE8-rot-out 53.29 APE67-dihe-in -73.45, -16.45 -88.03, 3.09 APE12-dist-out 23.235 APE11-dist-out 22.111 APE10-dist-out 24.861 APE9-dist-out 30.074 None None None XRAY 2.05 0.197 0.231 D 280 254 18 0 0 0 [[7, 271]] 1.0 6qav OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6YIDA Q8IYT8 1 274 1036.0 EDJ:60301 Type1 Inactive DFGin 6.475 16.141 BLAminus DFGAsp-rot-in -138.48, 169.52 70.29, 84.11 193.95, -11.08 -98.42, 26.46 289.51, 81.18 -60.97, -32.7 out-out out 10.11 Saltbr-out 5.285 HRD-in -78.13, -53.22 79.39, -8.18 out-in-none SNCoin in-none ActLoopNT-in 2.872 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.01, -25.35 999.0, 33.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.194 0.238 A 280 258 16 0 0 10 [[7, 271]] 1.0 6yid OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6YIDB Q8IYT8 1 273 1036.0 EDJ:60301 Type1 Inactive DFGin 6.471 15.826 BLAminus DFGAsp-rot-in -138.46, 171.26 70.27, 85.19 194.98, -16.12 -98.18, 28.09 291.19, 81.32 -64.14, -34.35 in-out in 9.974 Saltbr-out 5.622 HRD-in -77.11, -53.83 77.41, -5.23 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 93.11 APE8-rot-none 999.0 APE67-dihe-out -66.04, -25.62 -76.51, 73.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.194 0.238 B 280 260 13 0 0 9 [[7, 271]] 1.0 6yid OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6YIDC Q8IYT8 1 272 1036.0 EDJ:60301 Type1 Inactive DFGin 6.456 15.947 BLAminus DFGAsp-rot-in -139.09, 170.35 70.2, 83.67 194.7, -11.82 -99.13, 27.22 291.76, 82.28 -62.19, -33.75 out-out out 10.061 Saltbr-out 4.31 HRD-in -77.1, -53.34 79.66, -7.8 out-in-none SNCoin in-none ActLoopNT-in 2.87 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 86.82 APE8-rot-none 999.0 APE67-dihe-in -67.78, -24.58 -94.57, 24.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.194 0.238 C 280 256 16 0 0 9 [[7, 271]] 1.0 6yid OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK2 ULK2_HUMAN 6YIDD Q8IYT8 1 274 1036.0 EDJ:60301 Type1 Inactive DFGin 6.369 16.008 BLAminus DFGAsp-rot-in -138.94, 170.32 69.77, 84.21 195.0, -14.98 -99.27, 28.17 291.69, 81.84 -63.79, -32.79 out-out out 10.079 Saltbr-out 5.227 HRD-in -76.82, -53.32 79.15, -7.18 out-in-none SNCoin in-none ActLoopNT-in 2.86 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.61, -23.61 999.0, 30.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.194 0.238 D 280 256 18 0 0 10 [[7, 271]] 1.0 6yid OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER ULK3 ULK3_HUMAN AF-Q6PHR2-K1A Q6PHR2 6 278 472.0 No_ligand No_ligand Active DFGin 6.84 14.62 BLAminus DFGAsp-rot-in -135.29, 172.55 60.67, 72.35 198.96, 22.72 -82.84, 19.41 284.36, 71.72 -65.11, -14.26 in-in in 9.179 Saltbr-in 2.682 HRD-in -83.07, -39.81 64.5, -5.75 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.87, 163.75 APE9-dihe-na 102.1, -168.95 APE8-dihe-in -104.94, 119.14 APE8-rot-in 296.95 APE67-dihe-in -62.03, -17.08 -47.63, -47.95 APE12-dist-in 9.95 APE11-dist-in 11.922 APE10-dist-in 6.041 APE9-dist-in 3.564 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[14, 270]] 1.0 AF-Q6PHR2-K1 OTHER_ULK3_HUMAN ULK 2.9e-126 426.1 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER ULK3 ULK3_HUMAN AF-Q6PHR2-K3A Q6PHR2 6 278 472.0 No_ligand No_ligand Active DFGin 6.504 14.61 BLAminus DFGAsp-rot-in -138.73, 174.55 56.93, 72.25 202.81, 12.49 -79.74, 18.3 283.47, 71.68 -65.68, -6.08 in-in in 9.018 Saltbr-in 2.72 HRD-in -84.32, -36.1 65.16, -7.42 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.64, 149.2 APE9-dihe-na 91.5, -157.71 APE8-dihe-in -108.06, 116.63 APE8-rot-in 304.91 APE67-dihe-in -68.94, -22.48 -52.49, -29.55 APE12-dist-in 10.07 APE11-dist-in 11.432 APE10-dist-in 5.532 APE9-dist-in 3.942 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[14, 270]] 1.0 AF-Q6PHR2-K3 OTHER_ULK3_HUMAN ULK 2.9e-126 426.1 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER ULK3 ULK3_HUMAN 6FDYU Q6PHR2 9 274 472.0 DB8:301,DB8:302 Type1,Allosteric Inactive DFGin 6.874 15.807 BLAminus DFGAsp-rot-in -121.89, 168.03 58.05, 74.57 206.45, -17.21 -82.78, 25.82 281.46, 65.78 -64.66, -23.35 out-out out 11.318 Saltbr-out 6.975 HRD-in -73.35, -48.54 71.13, 8.1 out-in-in SNCoii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.42, 135.02 APE9-dihe-na 116.19, -156.99 APE8-dihe-in -126.23, 135.32 APE8-rot-in 297.86 APE67-dihe-in -77.76, -4.76 -49.56, -42.9 APE12-dist-in 9.776 APE11-dist-in 10.466 APE10-dist-in 5.312 APE9-dist-in 3.261 None None None XRAY 1.7 0.207 0.239 U 276 262 4 0 0 0 [[14, 270]] 1.0 6fdy OTHER_ULK3_HUMAN ULK 3e-126 426.0 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER ULK3 ULK3_HUMAN 6FDZU Q6PHR2 8 274 472.0 C87:301 Type1 Inactive DFGout 16.553 10.514 BBAminus DFGAsp-rot-in -120.49, 158.43 -115.91, 98.45 199.11, -32.21 -81.95, -5.01 269.43, 36.27 -131.59, 73.69 out-out out 14.553 Saltbr-out 12.568 HRD-out 48.3, 57.37 -83.36, -176.25 out-out-out SNCooo out-out ActLoopNT-out 11.38 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -113.87, 147.15 APE9-dihe-na 96.12, 142.67 APE8-dihe-in -98.65, 132.78 APE8-rot-out 174.87 APE67-dihe-in -71.05, -17.37 -76.83, -17.63 APE12-dist-in 10.964 APE11-dist-out 14.578 APE10-dist-out 11.003 APE9-dist-out 6.717 None None None XRAY 2.55 0.234 0.301 U 276 265 2 0 0 0 [[14, 270]] 1.0 6fdz OTHER_ULK3_HUMAN ULK 3e-126 426.0 1 256 256 156 157 158 160 162 44 62 66 134 136 135 137 195 183 178 177 176 175 174 173 172 92 Serine/threonine-protein kinase ULK3
OTHER ULK4 ULK4_HUMAN 6TSZU Q96C45 2 285 1275.0 AGS:60301 ATPlike Pseudo DFGin 6.37 18.271 ABAminus DFGAsp-rot-in -125.81, 9.4 -156.01, 117.6 173.67, -29.88 -115.95, 19.15 288.81, 81.65 -56.0, -43.19 out-na out 14.288 Saltbr-na 999.0 HRD-in -78.74, -35.33 74.51, -30.17 na-in-out SNCaio in-out ActLoopNT-in 2.748 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.27, 133.36 APE9-dihe-na -108.57, -165.46 APE8-dihe-in -71.23, 118.04 APE8-rot-in 324.52 APE67-dihe-in -65.15, -30.07 -62.89, -23.31 APE12-dist-in 8.579 APE11-dist-out 6.171 APE10-dist-out 9.182 APE9-dist-in 5.697 None None None XRAY 1.9 0.203 0.253 U 305 283 1 0 0 1 [[4, 280]] 1.0 6tsz OTHER_ULK4_HUMAN ULK 1.2e-118 401.1 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
OTHER ULK4 ULK4_HUMAN 6U5LA Q96C45 1 285 1275.0 3RJ:60301 Type1 Pseudo DFGin 6.226 18.455 ABAminus DFGAsp-rot-in -136.12, 15.31 -157.37, 109.67 185.68, -34.06 -112.82, 20.67 287.68, 79.1 -55.24, -38.19 out-na out 13.962 Saltbr-na 999.0 HRD-in -80.42, -35.75 72.37, -25.3 na-in-out SNCaio in-out ActLoopNT-in 2.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -90.65, 119.09 APE9-dihe-na -89.22, -142.79 APE8-dihe-in -86.05, 132.82 APE8-rot-out 161.95 APE67-dihe-in -66.84, -35.55 -76.04, -11.61 APE12-dist-in 8.948 APE11-dist-out 6.328 APE10-dist-out 9.158 APE9-dist-in 5.993 K172A,K173A None None XRAY 1.75 0.192 0.216 A 287 274 11 0 0 11 [[4, 280]] 1.0 6u5l OTHER_ULK4_HUMAN ULK 9.5e-119 401.4 1 256 256 138 139 140 142 144 34 46 50 118 120 119 121 201 189 184 183 182 181 180 179 178 76 Serine/threonine-protein kinase ULK4
OTHER WEE1 WEE1_HUMAN 9D0SA P30291 292 574 646.0 A1A1R:1515 Type1 Inactive DFGin 5.041 12.649 ABAminus DFGAsp-rot-in -112.64, -43.93 -89.2, 127.46 192.0, -60.1 -123.11, 22.98 301.01, 178.2 -75.26, -6.54 in-out in 9.963 Saltbr-out 3.685 HRD-in -87.58, -48.34 75.46, 6.13 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -60.63, 145.05 APE9-dihe-na -89.07, -168.93 APE8-dihe-in -46.25, 128.2 APE8-rot-na 194.23 APE67-dihe-in -63.28, -25.56 -63.43, -23.57 APE12-dist-in 8.468 APE11-dist-out 5.402 APE10-dist-out 9.047 APE9-dist-in 3.256 None None None XRAY 1.64 0.184 0.222 A 289 265 18 0 0 0 [[299, 569]] 1.0 9d0s OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 8WDKW P30291 293 569 646.0 No_ligand No_ligand Inactive DFGin 6.142 13.809 BLAminus DFGAsp-rot-in -135.3, -165.63 57.83, 66.38 181.16, 20.05 -83.03, 22.29 305.48, 176.57 -64.72, -35.41 out-out out 10.067 Saltbr-out 8.934 HRD-in -66.78, -51.08 57.87, 12.36 out-in-out SNCoio in-out ActLoopNT-in 3.233 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -57.15, 114.8 APE9-dihe-na -82.67, 173.89 APE8-dihe-in -62.77, 133.65 APE8-rot-na 282.12 APE67-dihe-in -66.98, -44.44 -63.95, -23.68 APE12-dist-in 8.195 APE11-dist-out 5.436 APE10-dist-out 10.291 APE9-dist-in 5.074 None None None EM 3.64 999.0 999.0 W 286 277 0 0 0 0 [[299, 569]] 1.0 8wdk OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN AF-P30291-K1A P30291 291 577 646.0 No_ligand No_ligand Inactive DFGin 5.761 12.257 BLAminus DFGAsp-rot-in -135.82, -172.6 55.56, 72.22 198.67, 23.01 -83.69, 18.83 304.3, 7.49 -61.76, -27.13 in-in in 8.36 Saltbr-in 2.731 HRD-in -83.67, -41.9 66.28, -13.91 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -69.97, 119.09 APE9-dihe-na -71.12, -158.4 APE8-dihe-in -62.95, 118.94 APE8-rot-na 192.3 APE67-dihe-in -66.18, -31.97 -56.0, -22.52 APE12-dist-in 8.444 APE11-dist-out 5.258 APE10-dist-out 9.273 APE9-dist-in 3.911 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[299, 569]] 1.0 AF-P30291-K1 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN AF-P30291-K3A P30291 291 577 646.0 No_ligand No_ligand Active DFGin 4.866 11.86 BLAminus DFGAsp-rot-in -118.36, -169.37 47.31, 77.75 197.13, 2.63 -89.78, 14.39 305.58, 173.72 -64.13, -32.36 in-in in 8.831 Saltbr-in 2.655 HRD-in -82.88, -39.61 66.04, -12.19 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -94.26, 0.59 APE9-dihe-na -62.04, 155.83 APE8-dihe-in -55.59, 102.45 APE8-rot-na 194.19 APE67-dihe-in -46.18, -69.31 -55.78, -18.65 APE12-dist-in 9.073 APE11-dist-in 10.755 APE10-dist-in 6.679 APE9-dist-in 4.367 None None None AF2 -1.0 1.0 1.0 A 287 287 0 0 0 0 [[299, 569]] 1.0 AF-P30291-K3 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 2Z2WA P30291 291 571 646.0 770:901 Type1 Inactive DFGin 4.838 12.22 BLAminus DFGAsp-rot-in -127.17, -168.49 50.18, 77.08 192.71, -22.14 -84.47, 18.98 306.03, 18.85 -65.25, -14.07 in-in in 9.01 Saltbr-in 2.986 HRD-in -79.02, -51.91 77.46, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.776 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -73.56, 137.65 APE9-dihe-na -75.28, -174.78 APE8-dihe-in -48.45, 129.4 APE8-rot-na 198.36 APE67-dihe-in -73.81, -21.71 -47.22, -36.17 APE12-dist-in 8.417 APE11-dist-out 5.262 APE10-dist-out 9.127 APE9-dist-in 3.257 None None CSO509 XRAY 2.22 0.218 0.271 A 285 261 20 0 0 0 [[299, 569]] 1.0 2z2w OTHER_WEE1_HUMAN OTHER 1.3e-37 135.6 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 7N3UA P30291 293 570 646.0 05J:601 Type1 Inactive DFGin 6.319 13.549 BLAminus DFGAsp-rot-in -120.69, -171.75 48.13, 89.48 200.88, -34.06 -99.11, 23.24 318.27, 179.12 -55.61, -27.73 out-out out 10.579 Saltbr-out 4.341 HRD-in -78.8, -57.12 78.46, 6.9 out-in-out SNCoio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -62.89, 122.2 APE9-dihe-na -63.31, -177.22 APE8-dihe-in -51.52, 135.18 APE8-rot-na 184.77 APE67-dihe-in -67.06, -25.88 -70.79, -23.84 APE12-dist-in 8.211 APE11-dist-out 5.027 APE10-dist-out 9.324 APE9-dist-in 3.522 None None None XRAY 2.65 0.22 0.267 A 285 261 17 0 0 0 [[299, 569]] 1.0 7n3u OTHER_WEE1_HUMAN OTHER 1.3e-37 135.6 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 8BJUA P30291 293 571 646.0 QT9:601 Type1 Inactive DFGin 6.393 13.131 BLAminus DFGAsp-rot-in -127.29, -176.34 57.17, 76.95 202.26, -17.39 -81.7, 4.56 310.03, 2.6 -51.43, -23.44 in-out in 9.997 Saltbr-out 5.018 HRD-in -83.11, -52.27 71.82, 12.22 out-in-out SNCoio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -60.04, 130.11 APE9-dihe-na -105.47, 174.81 APE8-dihe-in -76.38, 117.8 APE8-rot-na 189.76 APE67-dihe-in -64.86, -27.43 -56.59, -27.22 APE12-dist-in 8.162 APE11-dist-out 5.673 APE10-dist-out 9.553 APE9-dist-in 4.71 None None None XRAY 1.53 0.223 0.263 A 285 260 19 0 0 0 [[299, 569]] 1.0 8bju OTHER_WEE1_HUMAN OTHER 1.3e-37 135.6 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 2IN6A P30291 291 569 646.0 839:901 Type1 Inactive DFGin 5.208 12.275 BLAminus DFGAsp-rot-in -135.88, -163.41 52.06, 80.24 195.46, -25.0 -88.11, 20.2 299.67, 19.46 -61.58, -14.28 in-in in 9.042 Saltbr-in 2.689 HRD-in -89.65, -48.59 71.56, 6.69 in-in-out SNCiio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -69.28, 135.04 APE9-dihe-na -84.37, -171.8 APE8-dihe-in -46.59, 129.75 APE8-rot-na 197.52 APE67-dihe-in -67.03, -21.84 -55.12, -34.26 APE12-dist-in 8.417 APE11-dist-out 5.362 APE10-dist-out 9.051 APE9-dist-in 3.173 None None None XRAY 1.9 0.25 0.299 A 287 256 23 0 0 0 [[299, 569]] 1.0 2in6 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 2IO6A P30291 291 569 646.0 330:901 Type1 Inactive DFGin 5.195 12.65 BLAminus DFGAsp-rot-in -134.29, -167.28 54.07, 80.3 202.16, -21.8 -91.66, 21.89 300.98, 11.17 -69.74, -12.77 in-in in 9.186 Saltbr-in 2.827 HRD-in -79.63, -46.66 73.56, -0.61 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -75.91, 146.83 APE9-dihe-na -82.66, -172.64 APE8-dihe-in -44.8, 130.05 APE8-rot-na 200.79 APE67-dihe-in -69.92, -24.36 -65.98, -21.67 APE12-dist-in 8.459 APE11-dist-out 5.59 APE10-dist-out 9.05 APE9-dist-in 3.319 None None None XRAY 2.2 0.235 0.273 A 287 252 27 0 0 0 [[299, 569]] 1.0 2io6 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 3BI6A P30291 293 570 646.0 396:901 Type1 Inactive DFGin 5.119 12.586 BLAminus DFGAsp-rot-in -134.61, -165.44 49.67, 75.02 204.48, -25.69 -87.96, 24.65 302.28, 12.5 -63.14, -13.14 in-out in 9.489 Saltbr-out 4.884 HRD-in -79.34, -47.77 71.14, 2.53 out-in-out SNCoio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.17, 140.82 APE9-dihe-na -83.75, -168.45 APE8-dihe-in -49.11, 129.82 APE8-rot-na 193.99 APE67-dihe-in -61.15, -20.69 -65.03, -21.86 APE12-dist-in 8.426 APE11-dist-out 5.44 APE10-dist-out 8.941 APE9-dist-in 3.168 None None None XRAY 2.2 0.203 0.251 A 287 258 20 0 0 0 [[299, 569]] 1.0 3bi6 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 3BIZA P30291 293 569 646.0 61E:576 Type1 Inactive DFGin 5.063 12.402 BLAminus DFGAsp-rot-in -132.14, -162.38 51.65, 78.8 198.15, -24.73 -89.73, 21.42 301.21, 11.65 -56.65, -19.89 in-in in 9.073 Saltbr-in 2.949 HRD-in -79.42, -47.78 70.09, 4.75 in-in-out SNCiio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -71.18, 143.67 APE9-dihe-na -85.05, -164.13 APE8-dihe-in -48.36, 129.01 APE8-rot-na 196.32 APE67-dihe-in -60.07, -28.48 -61.79, -25.85 APE12-dist-in 8.315 APE11-dist-out 5.658 APE10-dist-out 8.924 APE9-dist-in 3.21 None None None XRAY 2.2 0.192 0.247 A 287 250 27 0 0 0 [[299, 569]] 1.0 3biz OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 3CQEA P30291 293 570 646.0 P91:901 Type1 Inactive DFGin 4.833 12.274 BLAminus DFGAsp-rot-in -128.01, -172.99 50.42, 71.96 206.13, -36.7 -79.57, 20.14 306.14, 12.05 -62.65, -13.4 in-out in 9.134 Saltbr-out 5.596 HRD-in -86.13, -47.2 72.65, 10.49 out-in-out SNCoio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.1, 141.95 APE9-dihe-na -77.08, -173.02 APE8-dihe-in -51.53, 134.7 APE8-rot-na 194.48 APE67-dihe-in -56.21, -23.92 -64.54, -27.61 APE12-dist-in 8.501 APE11-dist-out 5.762 APE10-dist-out 8.991 APE9-dist-in 3.213 None None None XRAY 2.5 0.212 0.268 A 287 258 20 0 0 0 [[299, 569]] 1.0 3cqe OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 3CR0A P30291 293 573 646.0 809:901 Type1 Inactive DFGin 4.926 12.422 BLAminus DFGAsp-rot-in -130.23, -169.34 53.76, 78.85 198.66, -24.3 -88.38, 20.89 297.86, 17.43 -66.49, -13.44 in-out in 9.422 Saltbr-out 4.986 HRD-in -87.94, -48.35 70.0, 3.11 out-in-out SNCoio in-out ActLoopNT-in 2.589 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -64.02, 138.46 APE9-dihe-na -77.3, -176.02 APE8-dihe-in -42.35, 131.74 APE8-rot-na 198.78 APE67-dihe-in -63.35, -26.06 -70.6, -16.82 APE12-dist-in 8.465 APE11-dist-out 5.205 APE10-dist-out 8.957 APE9-dist-in 3.086 None None None XRAY 2.3 0.208 0.255 A 287 257 24 0 0 0 [[299, 569]] 1.0 3cr0 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5V5YA P30291 293 569 646.0 8X7:601 Type1 Inactive DFGin 5.553 12.973 BLAminus DFGAsp-rot-in -129.44, -172.09 52.13, 74.42 195.32, -11.06 -91.12, 23.85 308.88, 2.25 -71.13, -17.8 in-in in 8.711 Saltbr-in 2.66 HRD-in -84.05, -47.91 67.9, 13.22 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -59.5, 118.21 APE9-dihe-na -83.22, -165.97 APE8-dihe-in -62.15, 119.68 APE8-rot-na 195.95 APE67-dihe-in -65.91, -27.53 -61.05, -24.64 APE12-dist-in 8.422 APE11-dist-out 5.439 APE10-dist-out 10.004 APE9-dist-in 4.343 None None None XRAY 1.9 0.173 0.215 A 289 259 18 0 0 0 [[299, 569]] 1.0 5v5y OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VC3A P30291 293 570 646.0 DB8:601 Type1 Inactive DFGin 5.869 13.847 BLAminus DFGAsp-rot-in -114.82, -178.11 54.56, 79.37 197.07, -4.72 -92.53, 24.23 299.17, 19.73 -68.72, -22.16 out-out out 10.357 Saltbr-out 5.286 HRD-in -86.82, -42.16 64.96, 14.12 out-in-out SNCoio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -59.88, 134.71 APE9-dihe-na -71.82, -169.68 APE8-dihe-in -52.32, 129.97 APE8-rot-na 194.6 APE67-dihe-in -75.75, -17.17 -62.12, -24.88 APE12-dist-in 8.32 APE11-dist-out 5.181 APE10-dist-out 9.248 APE9-dist-in 3.434 None None None XRAY 1.97 0.212 0.254 A 289 260 18 0 0 0 [[299, 569]] 1.0 5vc3 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VC4A P30291 293 571 646.0 XZN:601 Type1 Inactive DFGin 6.869 13.26 BLAminus DFGAsp-rot-in -128.24, -175.96 53.99, 85.77 203.98, -25.26 -95.76, 27.4 302.66, 11.0 -68.66, -12.8 in-out in 9.306 Saltbr-out 7.077 HRD-in -75.25, -47.07 67.81, 14.97 out-in-out SNCoio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -60.88, 143.97 APE9-dihe-na -91.58, -162.44 APE8-dihe-in -53.77, 129.16 APE8-rot-na 197.59 APE67-dihe-in -70.28, -22.97 -67.17, -20.66 APE12-dist-in 8.649 APE11-dist-out 5.72 APE10-dist-out 9.169 APE9-dist-in 3.7 None None None XRAY 2.1 0.198 0.241 A 289 261 18 0 0 0 [[299, 569]] 1.0 5vc4 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VC5A P30291 293 571 646.0 96M:601 Type1 Inactive DFGin 6.183 13.607 BLAminus DFGAsp-rot-in -109.75, 173.6 55.33, 81.58 194.3, -4.79 -83.75, 19.02 301.05, 16.73 -68.34, -18.42 in-out in 9.75 Saltbr-out 5.117 HRD-in -88.95, -46.93 71.27, 8.72 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -66.87, 147.74 APE9-dihe-na -93.78, -179.52 APE8-dihe-in -31.99, 120.36 APE8-rot-na 201.18 APE67-dihe-in -58.51, -29.97 -62.67, -24.71 APE12-dist-in 8.488 APE11-dist-out 5.352 APE10-dist-out 9.449 APE9-dist-in 4.056 None None None XRAY 1.93 0.176 0.217 A 289 261 18 0 0 0 [[299, 569]] 1.0 5vc5 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VC6A P30291 293 571 646.0 P48:601 Type1 Inactive DFGin 6.757 12.333 BLAminus DFGAsp-rot-in -124.34, -177.76 56.26, 81.95 195.93, -12.98 -92.8, 21.05 305.34, 6.74 -68.88, -15.34 in-in in 8.988 Saltbr-in 2.921 HRD-in -78.66, -45.99 69.6, 12.42 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -61.1, 146.51 APE9-dihe-na -81.74, -169.83 APE8-dihe-in -50.11, 123.98 APE8-rot-na 196.06 APE67-dihe-in -65.92, -28.6 -55.65, -25.34 APE12-dist-in 8.4 APE11-dist-out 5.692 APE10-dist-out 9.001 APE9-dist-in 3.573 None None None XRAY 2.0 0.22 0.265 A 289 259 20 0 0 0 [[299, 569]] 1.0 5vc6 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD2A P30291 293 569 646.0 34W:601 Type1 Inactive DFGin 5.993 13.806 BLAminus DFGAsp-rot-out -118.11, -175.73 48.54, 80.15 304.56, -26.02 -89.98, 23.36 303.91, 15.2 -66.61, -20.92 out-out out 10.103 Saltbr-out 5.226 HRD-in -86.76, -48.82 73.4, 11.77 out-in-out SNCoio in-out ActLoopNT-in 2.955 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -58.71, 139.12 APE9-dihe-na -81.5, -178.72 APE8-dihe-in -42.43, 125.68 APE8-rot-na 195.33 APE67-dihe-in -69.68, -23.11 -63.52, -20.81 APE12-dist-in 8.332 APE11-dist-out 5.434 APE10-dist-out 9.409 APE9-dist-in 3.596 None None None XRAY 2.05 0.206 0.256 A 289 258 19 0 0 0 [[299, 569]] 1.0 5vd2 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD4A P30291 293 571 646.0 99J:601 Type1 Inactive DFGin 6.861 12.927 BLAminus DFGAsp-rot-out -130.98, -167.59 50.1, 72.3 291.85, -32.57 -87.54, 22.86 305.1, 13.55 -67.24, -12.92 in-in in 9.031 Saltbr-in 3.335 HRD-in -79.99, -45.73 68.96, 7.59 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -72.75, 133.71 APE9-dihe-na -72.67, -176.44 APE8-dihe-in -45.72, 124.87 APE8-rot-na 195.91 APE67-dihe-in -66.04, -26.65 -58.18, -30.71 APE12-dist-in 8.558 APE11-dist-out 5.945 APE10-dist-out 9.484 APE9-dist-in 3.717 None None None XRAY 2.02 0.203 0.245 A 289 261 18 0 0 0 [[299, 569]] 1.0 5vd4 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD5A P30291 293 571 646.0 99M:601 Type1 Inactive DFGin 6.778 12.918 BLAminus DFGAsp-rot-in -128.2, -173.56 54.99, 76.73 198.52, -15.4 -89.21, 18.8 301.17, 19.64 -68.36, -17.97 in-in in 9.293 Saltbr-in 3.42 HRD-in -81.06, -46.16 66.99, 11.34 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -61.26, 141.17 APE9-dihe-na -79.99, -168.67 APE8-dihe-in -52.09, 130.25 APE8-rot-na 197.84 APE67-dihe-in -66.68, -23.25 -65.28, -24.97 APE12-dist-in 8.552 APE11-dist-out 5.514 APE10-dist-out 9.119 APE9-dist-in 3.428 None None None XRAY 2.05 0.195 0.234 A 289 260 19 0 0 0 [[299, 569]] 1.0 5vd5 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD7A P30291 293 571 646.0 99V:601 Type1 Inactive DFGin 6.933 12.877 BLAminus DFGAsp-rot-in -126.65, -177.13 54.27, 84.52 194.0, 17.65 -96.42, 23.29 301.36, 21.12 -73.94, -14.19 in-in in 9.255 Saltbr-in 3.385 HRD-in -82.18, -45.01 67.0, 13.94 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -63.03, 140.36 APE9-dihe-na -83.68, -172.99 APE8-dihe-in -47.73, 129.53 APE8-rot-na 196.74 APE67-dihe-in -66.79, -25.32 -63.17, -26.12 APE12-dist-in 8.377 APE11-dist-out 5.344 APE10-dist-out 9.211 APE9-dist-in 3.661 None None None XRAY 2.08 0.207 0.248 A 289 261 18 0 0 0 [[299, 569]] 1.0 5vd7 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD8A P30291 293 571 646.0 98M:601 Type1 Inactive DFGin 6.656 12.96 BLAminus DFGAsp-rot-in -127.85, -173.48 53.74, 78.38 199.21, -15.88 -92.99, 20.84 302.74, 17.61 -68.5, -16.16 in-in in 9.299 Saltbr-in 3.28 HRD-in -79.68, -47.39 69.28, 9.49 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -61.65, 143.28 APE9-dihe-na -83.22, -174.28 APE8-dihe-in -44.47, 128.12 APE8-rot-na 198.44 APE67-dihe-in -64.37, -26.48 -62.3, -26.51 APE12-dist-in 8.489 APE11-dist-out 5.333 APE10-dist-out 9.146 APE9-dist-in 3.545 None None None XRAY 1.85 0.203 0.247 A 289 260 19 0 0 0 [[299, 569]] 1.0 5vd8 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VD9A P30291 292 571 646.0 98G:601 Type1 Inactive DFGin 6.794 12.909 BLAminus DFGAsp-rot-out -127.32, -170.1 62.1, 74.03 297.09, -21.02 -91.03, 20.35 305.29, 14.81 -71.01, -11.92 in-out in 9.365 Saltbr-out 4.934 HRD-in -83.59, -44.02 66.38, 8.26 out-in-out SNCoio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -67.74, 137.08 APE9-dihe-na -73.92, -176.05 APE8-dihe-in -44.25, 123.47 APE8-rot-na 197.62 APE67-dihe-in -68.33, -22.71 -57.64, -23.8 APE12-dist-in 8.347 APE11-dist-out 5.266 APE10-dist-out 9.121 APE9-dist-in 3.458 None None None XRAY 1.87 0.202 0.253 A 289 261 19 0 0 0 [[299, 569]] 1.0 5vd9 OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 5VDAA P30291 293 571 646.0 98D:601 Type1 Inactive DFGin 6.679 12.748 BLAminus DFGAsp-rot-out -129.21, -167.67 57.74, 76.02 297.83, -24.79 -91.65, 16.71 305.27, 18.5 -71.06, -12.62 in-out in 9.388 Saltbr-out 4.288 HRD-in -82.3, -46.17 66.6, 6.66 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -64.63, 140.04 APE9-dihe-na -74.84, -178.6 APE8-dihe-in -43.17, 123.8 APE8-rot-na 202.97 APE67-dihe-in -75.1, -20.34 -55.48, -23.06 APE12-dist-in 8.346 APE11-dist-out 5.312 APE10-dist-out 9.082 APE9-dist-in 3.474 None None None XRAY 2.1 0.191 0.255 A 289 259 20 0 0 0 [[299, 569]] 1.0 5vda OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 1X8BA P30291 291 569 646.0 824:901 Type1 Inactive DFGin 5.138 12.078 BLAminus DFGAsp-rot-in -126.44, -167.26 52.99, 80.97 195.07, -23.73 -90.02, 18.86 302.17, 14.25 -66.11, -12.47 in-in in 8.799 Saltbr-in 2.729 HRD-in -82.83, -50.09 72.75, 8.93 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -58.07, 132.65 APE9-dihe-na -83.92, -172.43 APE8-dihe-in -49.42, 128.03 APE8-rot-na 195.04 APE67-dihe-in -69.68, -24.37 -54.98, -30.74 APE12-dist-in 8.154 APE11-dist-out 5.613 APE10-dist-out 9.138 APE9-dist-in 3.209 None None None XRAY 1.81 0.219 0.237 A 289 259 20 0 0 0 [[299, 569]] 1.0 1x8b OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 9D0QA P30291 291 573 646.0 A1A1S:60601 Type1 Inactive DFGin 4.991 13.291 BLAminus DFGAsp-rot-in -126.37, -166.34 43.31, 78.66 205.89, -49.15 -88.05, 23.54 308.22, 1.34 -72.32, -12.57 in-in in 9.679 Saltbr-in 3.207 HRD-in -79.45, -45.33 71.07, 5.66 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -57.46, 141.68 APE9-dihe-na -88.93, -169.45 APE8-dihe-in -45.97, 123.72 APE8-rot-na 200.19 APE67-dihe-in -62.99, -24.28 -60.53, -26.72 APE12-dist-in 8.699 APE11-dist-out 5.792 APE10-dist-out 9.103 APE9-dist-in 3.239 None None None XRAY 1.96 0.209 0.27 A 289 271 12 0 0 0 [[299, 569]] 1.0 9d0q OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 9D0QB P30291 291 574 646.0 A1A1S:60601 Type1 Inactive DFGin 4.994 13.273 BLAminus DFGAsp-rot-in -127.94, -168.56 55.12, 73.42 209.57, -60.0 -87.72, 17.69 303.02, 9.06 -80.97, 0.38 in-in in 9.306 Saltbr-in 3.26 HRD-in -78.84, -43.89 70.95, 5.06 in-in-out SNCiio in-out ActLoopNT-in 2.743 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -68.72, 146.91 APE9-dihe-na -85.12, -162.0 APE8-dihe-in -50.28, 125.71 APE8-rot-na 200.6 APE67-dihe-in -61.52, -27.55 -54.56, -30.66 APE12-dist-in 8.888 APE11-dist-out 6.233 APE10-dist-out 9.311 APE9-dist-in 3.242 None None None XRAY 1.96 0.209 0.27 B 289 274 10 0 0 0 [[299, 569]] 1.0 9d0q OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE1 WEE1_HUMAN 9D0RA P30291 292 574 646.0 A1A1T:1507 Type1 Inactive DFGin 5.018 12.48 BLAminus DFGAsp-rot-in -129.1, -172.67 63.37, 82.78 211.26, -38.82 -100.84, 31.01 299.17, 8.96 -86.32, 2.26 in-in in 9.408 Saltbr-in 2.823 HRD-in -92.11, -50.4 77.44, 1.54 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -75.99, 150.04 APE9-dihe-na -89.23, -159.16 APE8-dihe-in -50.8, 126.75 APE8-rot-na 203.03 APE67-dihe-in -62.75, -23.72 -52.81, -35.57 APE12-dist-in 8.334 APE11-dist-out 5.497 APE10-dist-out 8.711 APE9-dist-in 3.329 None None None XRAY 2.34 0.214 0.256 A 289 264 19 0 0 0 [[299, 569]] 1.0 9d0r OTHER_WEE1_HUMAN OTHER 1.4e-37 135.5 1 258 258 462 463 464 466 468 328 346 350 423 425 424 426 499 486 481 480 479 478 477 476 475 377 Wee1-like protein kinase
OTHER WEE2 WEE2_HUMAN AF-P0C1S8-K1A P0C1S8 204 494 567.0 No_ligand No_ligand Inactive DFGin 5.32 12.432 BLAminus DFGAsp-rot-in -134.3, -173.99 56.51, 72.13 201.0, 22.66 -83.29, 17.15 299.06, 178.27 -58.97, -32.71 in-in in 8.371 Saltbr-in 2.759 HRD-in -86.34, -43.98 65.43, -12.21 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -60.93, 117.49 APE9-dihe-na -76.85, -151.62 APE8-dihe-in -67.85, 108.91 APE8-rot-na 189.25 APE67-dihe-in -65.75, -31.9 -51.0, -20.9 APE12-dist-in 8.122 APE11-dist-out 5.363 APE10-dist-out 9.271 APE9-dist-in 4.545 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[72, 512]] 1.0 AF-P0C1S8-K1 OTHER_WEE2_HUMAN NEK 9.1e-28 133.4 4 139 258 379 380 381 383 385 241 259 263 336 338 337 339 416 403 398 397 396 395 394 393 392 290 Wee1-like protein kinase 2
OTHER WEE2 WEE2_HUMAN AF-P0C1S8-K3A P0C1S8 204 494 567.0 No_ligand No_ligand Active DFGin 4.894 12.497 BLAminus DFGAsp-rot-in -119.45, -168.98 52.61, 59.95 205.96, 24.98 -76.18, 12.61 302.76, 173.67 -62.64, -30.65 in-in in 8.577 Saltbr-in 2.676 HRD-in -81.7, -40.04 64.39, -17.02 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -105.49, 9.11 APE9-dihe-na -67.07, 172.0 APE8-dihe-in -63.15, 114.72 APE8-rot-na 187.96 APE67-dihe-in -76.52, -29.76 -55.98, -20.19 APE12-dist-in 7.89 APE11-dist-in 12.039 APE10-dist-in 7.972 APE9-dist-in 4.44 None None None AF2 -1.0 1.0 1.0 A 291 291 0 0 0 0 [[72, 512]] 1.0 AF-P0C1S8-K3 OTHER_WEE2_HUMAN NEK 9.1e-28 133.4 4 139 258 379 380 381 383 385 241 259 263 336 338 337 339 416 403 398 397 396 395 394 393 392 290 Wee1-like protein kinase 2
OTHER WEE2 WEE2_HUMAN 5VDKA P0C1S8 204 486 567.0 8X7:501 Type1 Inactive DFGin 6.475 12.764 BLAminus DFGAsp-rot-in -132.14, -176.96 59.49, 97.22 180.41, -21.51 -108.31, 27.61 318.48, 177.21 -67.75, -13.32 in-in in 8.879 Saltbr-in 2.343 HRD-in -78.19, -59.39 74.05, 21.2 in-in-out SNCiio in-out ActLoopNT-in 3.058 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -64.06, 140.87 APE9-dihe-na -77.49, -156.13 APE8-dihe-in -55.32, 132.04 APE8-rot-na 187.37 APE67-dihe-in -66.18, -15.37 -69.73, -32.22 APE12-dist-in 8.334 APE11-dist-out 5.93 APE10-dist-out 8.878 APE9-dist-in 3.418 None None None XRAY 2.7 0.228 0.284 A 297 260 23 0 0 0 [[72, 512]] 1.0 5vdk OTHER_WEE2_HUMAN NEK 9.6e-28 133.3 4 139 258 379 380 381 383 385 241 259 263 336 338 337 339 416 403 398 397 396 395 394 393 392 290 Wee1-like protein kinase 2
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.965 14.31 BLAminus DFGAsp-rot-in -123.5, -167.41 55.36, 79.67 189.86, 15.66 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 na-na na 15.412 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279 260 14 0 0 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.37 14.504 BLAminus DFGAsp-rot-in -142.95, -168.2 54.59, 81.56 173.49, 44.17 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 na-na na 15.664 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279 259 16 0 0 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.241 14.032 BLAminus DFGAsp-rot-out -121.41, -171.4 57.02, 71.32 294.85, 3.65 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 na-na na 15.506 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.134 APE11-dist-out 22.408 APE10-dist-out 25.402 APE9-dist-out 25.928 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279 270 5 0 0 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.576 14.733 BLAminus DFGAsp-rot-out -124.5, -174.3 56.61, 76.82 285.35, 31.8 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 na-na na 15.252 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.726 APE10-dist-out 25.875 APE9-dist-out 25.614 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279 272 2 0 0 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN AF-Q9H4A3-K1A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.919 12.267 BLAminus DFGAsp-rot-in -124.85, -163.73 58.77, 48.81 208.41, 29.5 -69.2, 9.5 304.02, 175.87 -66.92, -19.2 na-na na 15.044 Saltbr-na 999.0 HRD-in -70.23, -44.77 64.66, -7.25 na-in-in SNCaii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 148.96 APE9-dihe-na 141.57, -179.67 APE8-dihe-in -82.64, 118.12 APE8-rot-in 302.58 APE67-dihe-in -65.7, -18.39 -50.97, -36.48 APE12-dist-in 8.599 APE11-dist-in 11.968 APE10-dist-in 6.287 APE9-dist-in 3.584 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[220, 479]] 1.0 AF-Q9H4A3-K1 OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN AF-Q9H4A3-K3A Q9H4A3 212 487 2382.0 No_ligand No_ligand Active DFGin 6.762 12.893 BLAminus DFGAsp-rot-in -125.6, -163.55 58.64, 42.4 220.99, -9.16 -66.13, 8.03 302.27, 174.42 -67.33, -13.09 na-na na 14.292 Saltbr-na 999.0 HRD-in -73.13, -42.78 63.87, -11.34 na-in-in SNCaii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.46, 136.63 APE9-dihe-na 153.75, -172.1 APE8-dihe-in -96.01, 118.63 APE8-rot-in 299.38 APE67-dihe-in -65.38, -19.38 -50.44, -37.25 APE12-dist-in 9.024 APE11-dist-in 12.076 APE10-dist-in 6.521 APE9-dist-in 3.486 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[220, 479]] 1.0 AF-Q9H4A3-K3 OTHER_WNK1_HUMAN WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.799 14.806 BLAminus DFGAsp-rot-in -124.68, -165.52 44.5, 74.88 205.87, 16.05 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 na-na na 15.637 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.092 None None None XRAY 2.5 0.198 0.266 A 279 262 12 0 0 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.745 14.581 BLAminus DFGAsp-rot-out -133.01, -172.41 51.04, 69.52 293.64, -6.57 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 na-na na 14.861 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.902 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.599 None None None XRAY 2.5 0.198 0.266 B 279 266 9 0 0 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 4PWNA Q9H4A3 210 482 2382.0 No_ligand No_ligand Inactive DFGin 7.057 13.279 None DFGAsp-rot-out -116.45, -167.58 52.85, 34.92 292.24, 1.17 -53.76, -53.16 298.89, 177.5 -76.46, 5.08 na-na na 14.364 Saltbr-na 999.0 HRD-in -62.97, -49.68 71.0, -9.34 na-out-none SNCaon out-none ActLoopNT-out 7.524 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 153.02 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.84 0.231 0.274 A 274 245 28 0 0 13 [[220, 479]] 1.0 4pwn OTHER_WNK1_HUMAN WNK 9.3e-179 598.1 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK2 WNK2_HUMAN AF-Q9Y3S1-K1A Q9Y3S1 186 461 2297.0 No_ligand No_ligand Inactive DFGin 6.934 12.376 BLAminus DFGAsp-rot-out -120.89, -161.02 57.35, 44.89 280.28, 27.33 -67.15, 8.11 303.91, 176.5 -66.03, -16.82 na-na na 15.199 Saltbr-na 999.0 HRD-in -71.35, -44.99 64.44, -5.7 na-in-in SNCaii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.09, 149.05 APE9-dihe-na 142.14, -175.6 APE8-dihe-in -86.55, 118.64 APE8-rot-in 302.02 APE67-dihe-in -64.28, -20.73 -50.95, -36.03 APE12-dist-in 8.57 APE11-dist-in 12.029 APE10-dist-in 6.349 APE9-dist-in 3.549 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[194, 453]] 1.0 AF-Q9Y3S1-K1 OTHER_WNK2_HUMAN WNK 2.5e-177 593.4 1 260 260 341 342 343 345 347 224 242 246 320 322 321 323 378 367 362 361 360 359 358 357 356 276 Serine/threonine-protein kinase WNK2
OTHER WNK2 WNK2_HUMAN AF-Q9Y3S1-K3A Q9Y3S1 186 461 2297.0 No_ligand No_ligand Active DFGin 6.703 13.01 BLAminus DFGAsp-rot-in -128.69, -164.36 56.84, 43.1 225.06, -16.23 -64.95, 8.5 305.03, 177.08 -67.2, -13.34 na-na na 14.329 Saltbr-na 999.0 HRD-in -72.6, -42.44 63.46, -9.88 na-in-in SNCaii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.9, 136.91 APE9-dihe-na 150.13, -174.05 APE8-dihe-in -92.56, 119.06 APE8-rot-in 299.06 APE67-dihe-in -68.79, -16.43 -51.43, -35.59 APE12-dist-in 9.127 APE11-dist-in 12.208 APE10-dist-in 6.591 APE9-dist-in 3.52 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[194, 453]] 1.0 AF-Q9Y3S1-K3 OTHER_WNK2_HUMAN WNK 2.5e-177 593.4 1 260 260 341 342 343 345 347 224 242 246 320 322 321 323 378 367 362 361 360 359 358 357 356 276 Serine/threonine-protein kinase WNK2
OTHER WNK3 WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Inactive DFGin 6.954 12.201 BLAminus DFGAsp-rot-out -125.28, -164.72 58.79, 65.89 287.14, 66.7 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 na-na na 15.898 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.873 APE11-dist-in 11.829 APE10-dist-in 6.326 APE9-dist-in 3.706 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284 273 7 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Inactive DFGin 7.182 12.078 BLAminus DFGAsp-rot-out -111.0, -167.63 57.49, 63.76 293.15, 23.0 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 na-na na 15.641 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.136 APE11-dist-in 11.827 APE10-dist-in 6.044 APE9-dist-in 3.51 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284 267 11 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN AF-Q9BYP7-K1A Q9BYP7 138 413 1800.0 No_ligand No_ligand Active DFGin 6.889 12.98 BLAminus DFGAsp-rot-in -127.86, -170.31 51.19, 67.07 198.0, 4.35 -80.59, 16.08 296.42, 165.8 -59.91, -12.24 na-na na 11.853 Saltbr-na 999.0 HRD-in -74.15, -43.46 63.54, 6.1 na-in-in SNCaii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.95, 159.33 APE9-dihe-na 112.64, 174.47 APE8-dihe-in -75.54, 119.36 APE8-rot-in 288.71 APE67-dihe-in -65.88, -24.09 -50.36, -35.91 APE12-dist-in 9.157 APE11-dist-in 12.176 APE10-dist-in 6.319 APE9-dist-in 3.709 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K1 OTHER_WNK3_HUMAN WNK 2.4e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN AF-Q9BYP7-K3A Q9BYP7 138 413 1800.0 No_ligand No_ligand Active DFGin 6.845 13.242 BLAminus DFGAsp-rot-in -122.36, -167.46 54.43, 50.12 209.95, 3.25 -69.12, 12.6 299.84, 170.73 -69.16, -10.15 na-na na 14.056 Saltbr-na 999.0 HRD-in -73.96, -43.62 65.21, -17.19 na-in-in SNCaii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.38, 130.65 APE9-dihe-na 151.91, -174.28 APE8-dihe-in -95.75, 116.01 APE8-rot-in 302.1 APE67-dihe-in -70.78, -17.78 -50.96, -34.06 APE12-dist-in 9.807 APE11-dist-in 12.352 APE10-dist-in 6.577 APE9-dist-in 3.816 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[146, 405]] 1.0 AF-Q9BYP7-K3 OTHER_WNK3_HUMAN WNK 2.4e-178 596.7 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O21A Q9BYP7 135 407 1800.0 No_ligand No_ligand Inactive DFGin 7.089 13.04 BLAminus DFGAsp-rot-out -130.22, -166.98 56.55, 36.65 288.15, -0.14 -72.32, -23.91 287.14, 0.0 -71.99, -51.91 na-na na 14.042 Saltbr-na 999.0 HRD-in -65.7, -53.34 78.52, -13.63 na-out-out SNCaoo out-out ActLoopNT-out 6.167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -100.81, -13.76 APE9-dihe-na -67.15, 136.06 APE8-dihe-in -100.83, 102.01 APE8-rot-in 297.43 APE67-dihe-in -61.6, -28.57 -61.68, -28.02 APE12-dist-out 14.232 APE11-dist-in 10.957 APE10-dist-in 7.138 APE9-dist-out 6.373 None SEP304 SEP304 XRAY 2.06 0.182 0.221 A 285 273 0 0 0 0 [[146, 405]] 1.0 5o21 OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O21B Q9BYP7 135 408 1800.0 No_ligand No_ligand Inactive DFGin 7.243 13.16 BLAminus DFGAsp-rot-out -129.31, -170.95 59.13, 36.62 287.62, 1.25 -71.75, -29.06 285.2, 175.91 -68.89, -49.7 na-na na 14.095 Saltbr-na 999.0 HRD-in -65.4, -53.37 78.35, -11.45 na-out-out SNCaoo out-out ActLoopNT-out 6.118 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -97.26, -16.45 APE9-dihe-na -65.22, 137.04 APE8-dihe-in -103.34, 104.84 APE8-rot-in 297.31 APE67-dihe-in -63.5, -19.78 -64.45, -33.71 APE12-dist-out 14.237 APE11-dist-in 10.939 APE10-dist-in 7.15 APE9-dist-out 6.327 None SEP304 SEP304 XRAY 2.06 0.182 0.221 B 285 274 0 0 0 0 [[146, 405]] 1.0 5o21 OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 8EDHC Q9BYP7 136 407 1800.0 No_ligand No_ligand Inactive DFGin 7.051 13.367 BLAminus DFGAsp-rot-out -110.82, -163.79 56.99, 35.55 289.1, 3.26 -66.18, -50.38 272.7, 99.71 -65.98, -44.91 na-na na 15.574 Saltbr-na 999.0 HRD-in -67.12, -48.65 66.19, 5.82 na-out-none SNCaon out-none ActLoopNT-out 6.321 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 101.07, -30.02 999.0, 70.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 C 292 261 11 0 0 11 [[146, 405]] 1.0 8edh OTHER_WNK3_HUMAN WNK 1e-177 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 9D7QA Q9BYP7 130 407 1800.0 No_ligand No_ligand Inactive DFGin 6.731 12.085 BLAminus DFGAsp-rot-out -119.7, -152.41 38.07, 75.05 298.77, 9.86 -85.05, -42.94 283.7, 178.43 -104.28, -8.03 na-na na 14.691 Saltbr-na 999.0 HRD-in -54.92, -50.52 71.24, 2.32 na-out-none SNCaon out-none ActLoopNT-out 7.637 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -174.1 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 A 280 267 11 0 0 11 [[146, 405]] 1.0 9d7q OTHER_WNK3_HUMAN WNK 3.9e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 9D7QB Q9BYP7 132 407 1800.0 No_ligand No_ligand Inactive DFGin 7.61 13.056 BLAminus DFGAsp-rot-out -122.92, -158.49 49.74, 40.74 289.18, -5.86 -65.83, -46.73 276.93, 168.69 -83.68, -10.9 na-na na 15.765 Saltbr-na 999.0 HRD-in -75.84, -54.93 87.41, -18.52 na-out-none SNCaon out-none ActLoopNT-out 6.809 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E314A None None XRAY 3.301 0.181 0.27 B 280 265 11 0 0 11 [[146, 405]] 1.0 9d7q OTHER_WNK3_HUMAN WNK 3.9e-176 589.5 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 8EDHA Q9BYP7 137 406 1800.0 WGK:1901 Type1 Inactive DFGin 7.094 13.222 BLAminus DFGAsp-rot-out -113.28, -158.85 38.61, 44.98 296.53, 36.87 -66.43, -55.5 297.69, 174.74 -65.27, -44.78 na-na na 15.081 Saltbr-na 999.0 HRD-in -66.58, -45.78 72.18, -7.88 na-out-none SNCaon out-none ActLoopNT-out 7.431 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 135.32 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S308A None None XRAY 3.111 0.196 0.291 A 292 255 15 0 0 12 [[146, 405]] 1.0 8edh OTHER_WNK3_HUMAN WNK 1e-177 594.8 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O1VA Q9BYP7 134 412 1800.0 No_ligand No_ligand Inactive DFGin 7.418 15.265 BLBminus DFGAsp-rot-out -126.78, -175.31 62.8, 27.49 288.92, -1.85 -57.54, 129.59 281.55, 176.13 75.06, -4.41 na-na na 15.67 Saltbr-na 999.0 HRD-in -67.39, -48.91 79.12, -13.95 na-out-out SNCaoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -59.36, 127.09 APE9-dihe-na 140.24, 170.44 APE8-dihe-in -110.71, 124.87 APE8-rot-in 299.46 APE67-dihe-in -59.06, -27.71 -49.77, -43.12 APE12-dist-out 21.907 APE11-dist-out 22.498 APE10-dist-out 27.88 APE9-dist-out 23.796 None SEP304 SEP304 XRAY 1.723 0.175 0.208 A 285 279 0 0 0 0 [[146, 405]] 1.0 5o1v OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O1VB Q9BYP7 134 410 1800.0 No_ligand No_ligand Inactive DFGin 7.539 15.413 BLBminus DFGAsp-rot-out -132.28, -167.25 59.98, 27.87 285.48, -6.64 -57.12, 126.45 269.15, 178.63 74.16, -3.88 na-na na 15.777 Saltbr-na 999.0 HRD-in -66.75, -47.84 75.78, -12.44 na-out-out SNCaoo out-out ActLoopNT-out 9.4 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.61 APE8-dihe-in -106.7, 136.81 APE8-rot-out 140.72 APE67-dihe-in -66.36, -20.87 -59.17, -44.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 23.68 None SEP304 SEP304 XRAY 1.723 0.175 0.208 B 285 271 6 0 0 6 [[146, 405]] 1.0 5o1v OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O2CA Q9BYP7 129 496 1800.0 No_ligand No_ligand Inactive DFGin 6.879 13.12 BLBminus DFGAsp-rot-out -135.93, -172.46 48.56, 54.24 307.24, -11.54 -57.69, 139.99 308.96, 31.31 -79.16, 114.12 na-na na 13.659 Saltbr-na 999.0 HRD-in -61.64, -49.66 75.9, -16.67 na-out-out SNCaoo out-out ActLoopNT-out 9.116 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.48, -58.95 APE9-dihe-na -60.57, 154.77 APE8-dihe-in -112.79, 108.55 APE8-rot-in 304.36 APE67-dihe-in -53.4, -39.45 -41.38, -41.92 APE12-dist-out 15.301 APE11-dist-in 13.166 APE10-dist-out 8.658 APE9-dist-in 5.904 None None None XRAY 2.4 0.189 0.254 A 380 368 0 0 0 0 [[146, 405]] 1.0 5o2c OTHER_WNK3_HUMAN WNK 7.1e-178 595.4 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O2BB Q9BYP7 135 406 1800.0 KS1:60501 Type1 Inactive DFGin 7.27 14.975 BLBminus DFGAsp-rot-out -132.95, -165.51 54.58, 28.52 286.94, -17.26 -62.06, 130.41 264.18, 3.23 73.33, -0.53 na-na na 15.516 Saltbr-na 999.0 HRD-in -65.47, -46.21 70.06, -0.64 na-out-none SNCaon out-none ActLoopNT-out 9.655 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.28 APE8-rot-in 305.72 APE67-dihe-in -65.53, -27.3 -60.31, -23.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.038 0.201 0.24 B 285 257 15 0 0 10 [[146, 405]] 1.0 5o2b OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O2BA Q9BYP7 132 414 1800.0 KS1:60501 Type1 Inactive DFGin 6.818 15.282 BLBtrans DFGAsp-rot-out -124.49, -166.05 54.45, 24.2 288.46, -3.27 -67.59, 128.42 183.67, 57.58 81.34, -10.84 na-na na 15.093 Saltbr-na 999.0 HRD-in -62.07, -49.99 74.44, -8.41 na-out-out SNCaoo out-out ActLoopNT-out 8.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -72.1 APE9-dihe-na -158.08, -158.78 APE8-dihe-in -120.02, 111.61 APE8-rot-in 313.49 APE67-dihe-in -62.37, -25.73 -46.14, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.027 APE9-dist-out 23.146 None None None XRAY 2.038 0.201 0.24 A 285 268 15 0 0 8 [[146, 405]] 1.0 5o2b OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O23A Q9BYP7 136 405 1800.0 No_ligand No_ligand Inactive DFGin 6.267 15.747 None DFGAsp-rot-out -58.12, 150.75 -62.49, 153.69 70.78, -61.39 -74.35, -24.44 301.07, 176.19 -64.82, -47.37 na-na na 15.546 Saltbr-na 999.0 HRD-in -69.6, -49.52 69.26, 5.04 na-out-out SNCaoo out-out ActLoopNT-out 6.392 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 18.0 APE9-dihe-na -73.23, 148.07 APE8-dihe-in -120.2, 82.68 APE8-rot-out 60.44 APE67-dihe-in -69.8, -9.43 -68.14, -14.79 APE12-dist-out 16.581 APE11-dist-out 14.432 APE10-dist-out 11.091 APE9-dist-out 8.804 None SEP304 SEP304 XRAY 2.25 0.207 0.239 A 285 270 0 0 0 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O23B Q9BYP7 132 408 1800.0 No_ligand No_ligand Inactive DFGin 5.937 15.615 None DFGAsp-rot-out -58.71, 149.58 -63.07, 151.65 72.82, -65.19 -71.84, -20.45 305.92, 177.41 -66.4, -56.29 na-na na 16.051 Saltbr-na 999.0 HRD-in -79.22, -48.18 69.94, -5.08 na-out-out SNCaoo out-out ActLoopNT-out 6.617 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -117.39, 20.94 APE9-dihe-na -70.16, 151.66 APE8-dihe-in -125.85, 83.91 APE8-rot-out 52.59 APE67-dihe-in -66.53, -19.04 -68.8, -9.41 APE12-dist-out 16.409 APE11-dist-out 14.19 APE10-dist-out 10.908 APE9-dist-out 8.448 None SEP304 SEP304 XRAY 2.25 0.207 0.239 B 285 277 0 0 0 0 [[146, 405]] 1.0 5o23 OTHER_WNK3_HUMAN WNK 2.7e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK4 WNK4_HUMAN AF-Q96J92-K1A Q96J92 165 440 1243.0 No_ligand No_ligand Active DFGin 6.931 12.336 BLAminus DFGAsp-rot-in -125.29, -164.47 58.79, 49.06 208.49, 29.02 -68.69, 11.81 304.28, 176.85 -65.63, -20.7 na-na na 15.054 Saltbr-na 999.0 HRD-in -73.06, -45.26 63.36, -8.1 na-in-in SNCaii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.21, 153.56 APE9-dihe-na 134.36, -175.63 APE8-dihe-in -90.23, 119.88 APE8-rot-in 309.22 APE67-dihe-in -68.25, -18.44 -50.52, -35.54 APE12-dist-in 8.627 APE11-dist-in 12.08 APE10-dist-in 6.372 APE9-dist-in 3.587 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[173, 432]] 1.0 AF-Q96J92-K1 OTHER_WNK4_HUMAN WNK 2.3e-172 577.1 1 260 260 320 321 322 324 326 203 221 225 299 301 300 302 357 346 341 340 339 338 337 336 335 255 Serine/threonine-protein kinase WNK4
OTHER WNK4 WNK4_HUMAN AF-Q96J92-K3A Q96J92 165 440 1243.0 No_ligand No_ligand Active DFGin 6.942 12.78 BLAminus DFGAsp-rot-in -126.9, -164.01 58.79, 42.29 217.71, -9.47 -67.39, 10.43 300.33, 174.49 -66.37, -16.72 na-na na 14.379 Saltbr-na 999.0 HRD-in -75.33, -43.82 63.36, -11.6 na-in-in SNCaii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.67, 137.16 APE9-dihe-na 149.3, -173.83 APE8-dihe-in -94.04, 119.76 APE8-rot-in 301.59 APE67-dihe-in -65.32, -20.1 -50.53, -37.22 APE12-dist-in 9.056 APE11-dist-in 12.17 APE10-dist-in 6.552 APE9-dist-in 3.545 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[173, 432]] 1.0 AF-Q96J92-K3 OTHER_WNK4_HUMAN WNK 2.3e-172 577.1 1 260 260 320 321 322 324 326 203 221 225 299 301 300 302 357 346 341 340 339 338 337 336 335 255 Serine/threonine-protein kinase WNK4

OTHER / All / All

Total number of chains: 935
Active chains: 175
Total number of genes: 89
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 497 53.2% AF-Q2M2I8-K1A
DFGin ABAminus 135 14.4% AF-Q504Y2-K3A
DFGin None 85 9.1% 5GZAA
DFGin BLBminus 71 7.6% 5O1VA
None None 51 5.5% 4IX3A
DFGin BLBplus 36 3.9% 5UV4A
DFGout None 30 3.2% 4I93A
DFGin BLAplus 10 1.1% 7JXUA
DFGout BBAminus 8 0.9% 6FDZU
DFGin BLBtrans 6 0.6% 5DRBA
DFGinter None 5 0.5% 7MXJA
DFGinter BABtrans 1 0.1% 7QWKH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
OTHER BIR2 BIR2_ARATH 4L68A Q9LSI9 272 600 605.0 PDO:60701 Allosteric Pseudo DFGin 9.12 13.554 BLBminus DFGAsp-rot-out -102.75, 164.19 78.08, 3.07 289.78, -3.51 -61.21, 134.13 312.77, 999.0 84.79, -0.01 out-out out 13.782 Saltbr-out 15.36 HRD-in -67.43, -47.03 75.0, -5.42 out-out-out SNCooo out-out ActLoopNT-out 5.938 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nioi APE10-dihe-na -95.05, 4.01 APE9-dihe-na 129.54, -165.7 APE8-dihe-in -116.84, 144.73 APE8-rot-na 179.81 APE67-dihe-inflip 91.69, -13.11 -52.03, 129.52 APE12-dist-none 999.0 APE11-dist-in 11.902 APE10-dist-out 15.357 APE9-dist-in 3.82 None None None XRAY 2.0 0.191 0.213 A 340 313 16 0 0 11 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BIR2 BIR2_ARATH 4L68B Q9LSI9 271 600 605.0 No_ligand No_ligand Pseudo DFGin 9.495 13.641 BLBminus DFGAsp-rot-out -104.07, 171.02 73.8, -2.3 288.34, -9.07 -55.39, 130.02 301.68, 999.0 88.64, -4.13 out-out out 13.837 Saltbr-out 15.342 HRD-in -71.67, -49.97 80.05, -2.9 out-out-out SNCooo out-out ActLoopNT-out 6.083 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -93.83, 137.13 APE9-dihe-na -65.39, -157.74 APE8-dihe-out -87.47, -29.3 APE8-rot-na 172.43 APE67-dihe-out 162.38, 161.42 -146.69, 18.8 APE12-dist-out 22.835 APE11-dist-out 27.482 APE10-dist-out 27.665 APE9-dist-out 31.74 None None None XRAY 2.0 0.191 0.213 B 340 320 10 0 0 10 [[306, 577]] 1.0 4l68 Arabidopsis thaliana OTHER_BIR2_ARATH TKL 2.4e-44 157.9 4 266 263 446 447 448 450 452 335 350 354 426 428 427 429 490 478 473 472 471 470 469 468 467 380 Inactive LRR receptor-like serine/threonine-protein kinase BIR2
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.087 4.579 None DFGAsp-rot-na -62.85, 129.32 -64.9, -25.87 63.28, 999.0 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.492 Saltbr-out 11.168 HRD-na-V -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.116 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.651 APE11-dist-in 13.035 APE10-dist-out 13.738 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.9e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.167 4.564 None DFGAsp-rot-na -61.22, 131.83 -70.76, -19.93 58.0, 999.0 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.61 Saltbr-out 11.562 HRD-na-V -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.638 APE11-dist-in 12.966 APE10-dist-out 14.136 APE9-dist-out 9.048 None None None XRAY 1.8 0.176 0.218 B 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.9e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I92A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.158 4.503 None DFGAsp-rot-na -61.91, 128.06 -64.53, -19.55 64.6, 999.0 -63.02, -32.76 295.83, 136.16 -71.51, -4.32 out-out out 12.243 Saltbr-out 10.618 HRD-na-V -137.1, 130.87 -99.42, 125.04 out-out-out SNCooo out-out ActLoopNT-out 7.549 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -72.8, -24.34 APE9-dihe-na -114.6, 124.96 APE8-dihe-in -57.47, 142.35 APE8-rot-na 288.82 APE67-dihe-in -56.47, -25.62 -59.24, -24.8 APE12-dist-in 12.687 APE11-dist-out 17.668 APE10-dist-out 12.461 APE9-dist-out 8.159 None None None XRAY 1.6 0.161 0.183 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i92 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.9e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93A Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.427 4.497 None DFGAsp-rot-na -66.16, 131.32 -65.62, -20.78 62.55, 999.0 -61.54, -32.08 294.88, 141.88 -71.37, -4.79 out-out out 12.372 Saltbr-out 10.901 HRD-na-V -139.73, 134.34 -102.66, 127.15 out-out-out SNCooo out-out ActLoopNT-out 7.578 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -96.34, -20.96 APE9-dihe-na -65.99, 130.67 APE8-dihe-in -66.24, 142.18 APE8-rot-na 187.32 APE67-dihe-in -58.9, -21.18 -65.5, -18.1 APE12-dist-in 13.821 APE11-dist-in 12.207 APE10-dist-out 13.515 APE9-dist-out 8.198 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.9e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I93B Q9FHD7 40 328 487.0 No_ligand No_ligand Pseudo DFGout 11.368 4.478 None DFGAsp-rot-na -62.63, 134.05 -67.17, -20.35 63.36, 999.0 -61.56, -31.26 298.97, 139.62 -77.7, -1.04 out-out out 12.587 Saltbr-out 11.096 HRD-na-V -145.3, 130.74 -99.64, 132.89 out-out-none SNCoon out-none ActLoopNT-out 8.009 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -52.43 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE115,MSE135,MSE152,MSE156,MSE203,MSE267,MSE269,MSE310 XRAY 1.5 0.181 0.208 B 300 283 6 0 0 6 [[64, 311]] 1.0 4i93 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.9e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER MLKL2 Q9FGG5_ARATH 6LBAA Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None DFGAsp-rot-none -122.97, 148.56 93.16, 0.89 999.0, 999.0 -63.48, -42.05 51.06, 103.73 -82.35, 163.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.95, -60.85 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.21 APE67-dihe-in -62.28, -7.76 -72.46, -6.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 A 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.3e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAB Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None DFGAsp-rot-none -122.97, 148.57 93.19, 0.89 999.0, 999.0 -63.46, -42.1 51.1, 103.74 -82.32, 163.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.59, -40.18 73.9, -60.83 none-out-none SNCnon out-none ActLoopNT-out 10.547 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.29 APE8-rot-na 30.18 APE67-dihe-in -62.24, -7.82 -72.49, -6.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 B 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.3e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAC Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.731 999.0 None DFGAsp-rot-none -123.02, 148.57 93.19, 0.88 999.0, 999.0 -63.44, -42.08 51.11, 103.72 -82.32, 163.57 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.99, -60.87 none-out-none SNCnon out-none ActLoopNT-out 10.549 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.3 APE8-rot-na 30.19 APE67-dihe-in -62.3, -7.76 -72.5, -6.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 C 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.3e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL2 Q9FGG5_ARATH 6LBAD Q9FGG5 1 570 711.0 No_ligand No_ligand Pseudo None 6.73 999.0 None DFGAsp-rot-none -123.01, 148.57 93.2, 0.79 999.0, 999.0 -63.42, -42.02 51.11, 103.73 -82.4, 163.58 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.58, -40.22 73.98, -60.84 none-out-none SNCnon out-none ActLoopNT-out 10.548 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 151.34 APE8-rot-na 30.2 APE67-dihe-in -62.23, -7.79 -72.5, -6.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 4.1 999.0 999.0 D 572 464 74 0 0 13 [[250, 508]] 1.0 6lba Arabidopsis thaliana OTHER_MLKL2_ARATH TKL 8.3e-39 140.1 20 265 246 382 383 384 386 388 265 277 281 356 358 357 359 433 410 405 404 403 402 401 400 399 309 Protein kinase family protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4A Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None DFGAsp-rot-none -142.13, 171.5 85.9, 1.28 999.0, 999.0 -63.61, -40.11 50.83, 88.77 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.16, 132.9 -63.4, -51.31 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.65 APE8-rot-na 24.5 APE67-dihe-out -127.8, -55.85 -82.83, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 A 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.5e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4B Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.802 999.0 None DFGAsp-rot-none -142.18, 171.46 85.97, 1.26 999.0, 999.0 -63.61, -40.11 50.83, 88.78 -77.79, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.14, 132.89 -63.44, -51.21 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.63 APE8-rot-na 24.5 APE67-dihe-out -127.76, -55.87 -82.87, 72.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 B 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.5e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4C Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.801 999.0 None DFGAsp-rot-none -142.14, 171.51 85.88, 1.33 999.0, 999.0 -63.66, -40.1 50.84, 88.73 -77.78, 165.14 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.18, 132.86 -63.33, -51.38 na-out-out SNCaoo out-out ActLoopNT-out 9.485 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.58 APE8-rot-na 24.47 APE67-dihe-out -127.78, -55.8 -82.92, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 C 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.5e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER MLKL3 Q9LMN2_ARATH 6KA4D Q9LMN2 325 900 1025.0 No_ligand No_ligand Pseudo None 6.803 999.0 None DFGAsp-rot-none -142.12, 171.53 85.87, 1.26 999.0, 999.0 -63.58, -40.16 50.84, 88.79 -77.77, 165.1 none-na none 999.0 Saltbr-na 999.0 HRD-out -64.2, 132.96 -63.47, -51.27 na-out-out SNCaoo out-out ActLoopNT-out 9.486 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -117.62 APE8-rot-na 24.59 APE67-dihe-out -127.79, -55.89 -82.86, 72.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.4 999.0 999.0 D 701 534 34 0 0 17 [[570, 833]] 1.0 6ka4 Arabidopsis thaliana OTHER_MLKL3_ARATH TKL 3.5e-35 128.8 50 265 216 705 706 707 709 711 0 0 602 677 679 678 680 758 737 732 731 730 729 728 727 726 630 F22L4.1 protein
OTHER T1N2412 Q94K14_ARATH 8K20B Q94K14 14 221 226.0 No_ligand No_ligand Inactive DFGin 4.609 13.96 BLAminus DFGAsp-rot-in -129.33, -173.21 60.26, 65.83 185.85, 74.22 -84.73, 21.08 283.76, 25.67 -63.22, -31.98 in-out in 8.541 Saltbr-out 6.398 HRD-in -117.02, -53.78 90.26, -11.06 out-in-na SNCoia in-na ActLoopNT-in 2.931 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.2, -42.0 APE9-dihe-na -62.58, -40.78 APE8-dihe-na -64.87, -38.96 APE8-rot-na 161.68 APE67-dihe-na -64.77, -38.14 -62.31, -46.3 APE12-dist-na 16.156 APE11-dist-na 11.62 APE10-dist-na 14.763 APE9-dist-na 11.226 None None None EM 3.7 999.0 999.0 B 226 208 10 0 0 0 [[9, 226]] 1.0 8k20 Arabidopsis thaliana OTHER_T1N2412_ARATH TP53RK 4.8e-82 280.8 4 224 221 155 156 157 159 161 36 60 64 134 136 135 137 172 178 173 172 171 170 169 168 167 90 non-specific serine/threonine protein kinase
OTHER ZRK1 ZRK1_ARATH 6J5TB Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.313 13.073 BLAminus DFGAsp-rot-out -156.34, -175.12 59.27, 64.62 284.97, -33.17 -89.46, 24.4 308.39, 176.41 -69.32, -19.98 na-na na 8.942 Saltbr-na 3.223 HRD-out -77.03, 86.47 -70.01, -23.72 na-in-out SNCaio in-out ActLoopNT-in 3.303 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -156.59, 152.54 APE9-dihe-na 109.67, 105.32 APE8-dihe-out 61.29, 79.63 APE8-rot-in 313.8 APE67-dihe-out 93.38, -52.49 -35.54, 132.58 APE12-dist-in 11.43 APE11-dist-in 12.48 APE10-dist-in 7.78 APE9-dist-out 6.939 None None None EM 3.4 999.0 999.0 B 351 327 4 0 0 0 [[62, 342]] 1.0 6j5t Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5TE Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.313 13.073 BLAminus DFGAsp-rot-out -156.34, -175.09 59.31, 64.58 284.97, -33.16 -89.51, 24.41 308.36, 176.42 -69.24, -20.08 na-na na 8.942 Saltbr-na 3.223 HRD-out -77.03, 86.5 -70.08, -23.67 na-in-out SNCaio in-out ActLoopNT-in 3.303 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -156.65, 152.54 APE9-dihe-na 109.71, 105.26 APE8-dihe-out 61.3, 79.57 APE8-rot-in 313.87 APE67-dihe-out 93.48, -52.54 -35.53, 132.54 APE12-dist-in 11.43 APE11-dist-in 12.48 APE10-dist-in 7.78 APE9-dist-out 6.939 None None None EM 3.4 999.0 999.0 E 351 327 4 0 0 0 [[62, 342]] 1.0 6j5t Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5TH Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.313 13.073 BLAminus DFGAsp-rot-out -156.38, -175.12 59.27, 64.65 284.91, -33.15 -89.48, 24.41 308.31, 176.42 -69.26, -20.05 na-na na 8.942 Saltbr-na 3.224 HRD-out -77.06, 86.56 -70.04, -23.69 na-in-out SNCaio in-out ActLoopNT-in 3.303 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -156.6, 152.58 APE9-dihe-na 109.62, 105.3 APE8-dihe-out 61.24, 79.6 APE8-rot-in 313.87 APE67-dihe-out 93.44, -52.46 -35.5, 132.54 APE12-dist-in 11.429 APE11-dist-in 12.479 APE10-dist-in 7.78 APE9-dist-out 6.939 None None None EM 3.4 999.0 999.0 H 351 327 4 0 0 0 [[62, 342]] 1.0 6j5t Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5TK Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.313 13.073 BLAminus DFGAsp-rot-out -156.38, -175.12 59.31, 64.57 284.96, -33.15 -89.42, 24.37 308.41, 176.42 -69.3, -19.99 na-na na 8.942 Saltbr-na 3.224 HRD-out -77.05, 86.53 -70.05, -23.67 na-in-out SNCaio in-out ActLoopNT-in 3.303 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -156.62, 152.52 APE9-dihe-na 109.67, 105.27 APE8-dihe-out 61.3, 79.58 APE8-rot-in 313.84 APE67-dihe-out 93.37, -52.44 -35.53, 132.57 APE12-dist-in 11.43 APE11-dist-in 12.479 APE10-dist-in 7.78 APE9-dist-out 6.939 None None None EM 3.4 999.0 999.0 K 351 327 4 0 0 0 [[62, 342]] 1.0 6j5t Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5TN Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.313 13.073 BLAminus DFGAsp-rot-out -156.36, -175.12 59.33, 64.59 284.97, -33.16 -89.48, 24.39 308.36, 176.38 -69.29, -20.01 na-na na 8.942 Saltbr-na 3.223 HRD-out -77.08, 86.54 -70.07, -23.69 na-in-out SNCaio in-out ActLoopNT-in 3.303 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -156.65, 152.55 APE9-dihe-na 109.67, 105.37 APE8-dihe-out 61.27, 79.55 APE8-rot-in 313.83 APE67-dihe-out 93.45, -52.49 -35.43, 132.54 APE12-dist-in 11.429 APE11-dist-in 12.48 APE10-dist-in 7.781 APE9-dist-out 6.939 None None None EM 3.4 999.0 999.0 N 351 327 4 0 0 0 [[62, 342]] 1.0 6j5t Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5UB Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 4.865 13.219 BLAminus DFGAsp-rot-out -125.86, -169.86 37.75, 65.72 65.97, 3.55 -70.64, 78.99 303.05, 172.54 -131.92, 2.32 na-na na 9.357 Saltbr-na 6.105 HRD-out -116.63, 124.33 -92.57, 25.08 na-in-out SNCaio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -138.04, 135.66 APE9-dihe-na 118.43, 107.48 APE8-dihe-out 60.97, 78.11 APE8-rot-out 71.56 APE67-dihe-inflip 102.17, -42.2 -51.19, 136.83 APE12-dist-in 10.603 APE11-dist-in 11.963 APE10-dist-in 6.724 APE9-dist-in 5.326 None None None EM 3.9 999.0 999.0 B 351 327 4 0 0 0 [[62, 342]] 1.0 6j5u Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5VB Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.195 13.503 BLAminus DFGAsp-rot-out -148.89, -168.46 38.8, 63.08 57.76, -79.24 -71.69, 79.32 303.42, 149.19 -138.17, 13.08 na-na na 9.53 Saltbr-na 5.337 HRD-out -111.33, 130.81 -88.3, 16.4 na-in-out SNCaio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiii APE10-dihe-na -159.65, 139.82 APE9-dihe-na 116.37, 98.61 APE8-dihe-out 57.46, 74.47 APE8-rot-in 306.65 APE67-dihe-inflip 110.67, -31.12 -37.02, 130.61 APE12-dist-in 10.374 APE11-dist-in 12.455 APE10-dist-in 7.521 APE9-dist-in 5.246 None None None EM 4.25 999.0 999.0 B 351 327 4 0 0 0 [[62, 342]] 1.0 6j5v Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J6IB Q9SVY5 17 347 351.0 No_ligand No_ligand Inactive DFGin 5.485 13.357 BLAminus DFGAsp-rot-out -161.63, -170.01 63.11, 57.54 290.25, -31.64 -84.53, 21.82 297.63, 173.22 -67.34, -29.07 na-na na 8.911 Saltbr-na 2.763 HRD-out -79.98, 97.12 -72.99, -18.56 na-in-out SNCaio in-out ActLoopNT-in 3.267 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -152.48, 154.99 APE9-dihe-na 113.84, 101.13 APE8-dihe-out 48.71, 86.61 APE8-rot-out 183.28 APE67-dihe-inflip 90.94, 9.83 -32.25, 128.82 APE12-dist-in 11.451 APE11-dist-in 11.797 APE10-dist-in 7.513 APE9-dist-out 6.316 None None None EM 3.7 999.0 999.0 B 351 327 4 0 0 0 [[62, 342]] 1.0 6j6i Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER ZRK1 ZRK1_ARATH 6J5WB Q9SVY5 15 347 351.0 No_ligand No_ligand Inactive DFGin 5.473 13.095 BLAplus DFGAsp-rot-out -159.31, -175.15 32.01, 55.06 61.81, 8.51 -84.65, 49.46 56.51, 153.49 -77.18, -23.18 na-na na 8.907 Saltbr-na 2.619 HRD-out -71.97, 106.84 -74.41, -39.59 na-out-none SNCaon out-none ActLoopNT-out 3.603 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None EM 3.7 999.0 999.0 B 351 306 27 0 0 24 [[62, 342]] 1.0 6j5w Arabidopsis thaliana OTHER_ZRK1_ARATH TKL 6e-36 130.4 14 266 253 208 209 210 212 214 87 107 111 188 190 189 191 250 238 233 232 231 230 229 228 227 138 Serine/threonine-protein kinase ZRK1
OTHER YABT PKN1_BACSU 6G4JA P37562 1 273 338.0 No_ligand No_ligand Inactive DFGin 5.928 11.379 ABAminus DFGAsp-rot-in -103.29, -7.53 -152.84, 129.79 189.41, 81.52 -106.85, 12.82 294.28, 999.0 -56.32, 140.47 in-in in 6.995 Saltbr-in 2.684 HRD-in -65.5, -46.0 84.57, -89.88 in-in-out SNCiio in-out ActLoopNT-in 2.812 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -104.09, 106.59 APE9-dihe-na -149.78, 163.51 APE8-dihe-in -121.93, 124.77 APE8-rot-in 300.22 APE67-dihe-in -60.5, -27.46 -44.89, -50.6 APE12-dist-in 7.902 APE11-dist-out 7.786 APE10-dist-in 4.147 APE9-dist-in 5.496 None None None XRAY 1.599 0.19 0.217 A 315 273 34 0 0 0 [[28, 307]] 1.0 6g4j Bacillus subtilis OTHER_YABT_BACSU CMGC 1.2e-10 47.3 1 228 228 166 167 168 170 172 55 66 70 145 147 146 148 202 189 184 183 182 181 180 179 178 106 Serine/threonine-protein kinase YabT
OTHER LANKC A0A6H0TJ16_BACTU 8SAPA A0A6H0TJ16 4 863 872.0 No_ligand No_ligand Inactive DFGin 6.795 14.904 ABAminus DFGAsp-rot-in -121.29, -36.24 -117.7, 132.43 172.94, 72.64 -132.94, 22.61 282.97, 79.57 -59.5, -15.68 in-in in 7.333 Saltbr-in 2.788 HRD-na-- -71.75, 103.38 -86.0, 23.18 in-in-none SNCiin in-none ActLoopNT-in 2.727 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.192 0.25 A 875 833 0 0 0 0 [[228, 410]] 1.0 8sap Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAPB A0A6H0TJ16 1 863 872.0 No_ligand No_ligand Inactive DFGin 6.865 15.246 ABAminus DFGAsp-rot-out -118.64, -46.78 -106.84, 112.14 316.57, -43.63 -111.49, 20.5 280.78, 75.92 -58.55, -17.34 in-in in 7.497 Saltbr-in 2.801 HRD-na-- -75.72, 109.03 -86.17, 25.07 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.192 0.25 B 875 842 0 0 0 0 [[228, 410]] 1.0 8sap Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.64 14.881 BLAminus DFGAsp-rot-in -119.81, 176.45 65.16, 86.81 194.33, 0.5 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.41 Saltbr-in 2.775 HRD-na-- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904 845 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.5e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB A0A6H0TJ16 1 862 872.0 ATP:60901 ATPlike Inactive DFGin 6.749 15.009 BLAminus DFGAsp-rot-in -116.86, 172.09 66.52, 88.25 193.39, -5.55 -108.59, 34.42 278.94, 73.78 -73.89, -19.99 in-out in 7.479 Saltbr-out 3.865 HRD-na-- -85.28, 118.03 -78.23, 6.03 out-in-none SNCoin in-none ActLoopNT-in 2.764 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 B 904 844 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.5e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAOB A0A6H0TJ16 4 862 872.0 No_ligand No_ligand Inactive DFGin 6.396 14.946 BLAminus DFGAsp-rot-in -98.21, 179.92 60.5, 113.26 198.51, -16.78 -132.76, 41.69 271.55, 91.64 -72.51, -12.77 in-out in 7.797 Saltbr-out 3.966 HRD-na-- -65.7, -20.61 87.04, -45.22 out-in-none SNCoin in-none ActLoopNT-in 2.915 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.502 0.249 0.307 B 859 845 0 0 0 0 [[228, 410]] 1.0 8sao Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAOD A0A6H0TJ16 4 862 872.0 No_ligand No_ligand None DFGin 6.279 14.693 BLAminus DFGAsp-rot-in -127.01, -175.75 60.9, 110.51 197.96, -17.24 -134.43, 28.25 273.89, 91.9 -76.89, -10.35 in-in in 7.91 Saltbr-in 2.986 HRD-na-- -74.11, -15.09 88.71, -29.49 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.502 0.249 0.307 D 859 845 0 0 0 0 [[228, 410]] 1.0 8sao Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER STKLD1 F1MSZ0_BOVIN 9FQRXR F1MSZ0 1 610 639.0 No_ligand No_ligand Pseudo DFGin 6.896 13.145 BLBminus DFGAsp-rot-in -134.69, 167.6 69.62, 51.59 199.42, 15.05 -66.55, 132.48 297.73, 161.29 -107.87, 152.84 out-out out 14.762 Saltbr-out 12.944 HRD-in -60.65, -50.75 79.55, -12.94 out-out-out SNCooo out-out ActLoopNT-out 9.598 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.75, -17.84 APE9-dihe-na -83.29, -27.47 APE8-dihe-out -101.65, -16.85 APE8-rot-na 289.97 APE67-dihe-in -73.99, -1.71 -81.73, -21.53 APE12-dist-out 20.029 APE11-dist-out 19.061 APE10-dist-out 22.971 APE9-dist-out 14.584 None None None EM 5.0 999.0 999.0 Xr 756 579 21 0 0 0 [[4, 271]] 1.0 9fqr Bos taurus OTHER_STKLD1_BOVIN STE 3.1e-31 115.2 5 257 253 150 151 152 154 156 33 49 53 130 132 131 133 192 181 176 175 174 173 172 171 170 85 Serine/threonine kinase like domain containing 1
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.585 12.852 None DFGAsp-rot-none -92.38, -13.16 -130.85, 61.75 999.0, 999.0 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.543 APE10-dist-na 5.105 APE9-dist-na 11.572 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438 405 0 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.616 12.918 None DFGAsp-rot-none -91.62, -15.83 -130.65, 63.54 999.0, 999.0 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.58 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.175 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.893 APE11-dist-na 5.478 APE10-dist-na 5.079 APE9-dist-na 11.87 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438 406 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.492 12.647 None DFGAsp-rot-none -89.83, -13.71 -129.71, 95.5 999.0, 999.0 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.568 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.036 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.87 APE11-dist-na 5.412 APE10-dist-na 5.104 APE9-dist-na 11.702 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438 397 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.581 12.83 None DFGAsp-rot-none -92.56, -14.61 -129.54, 61.33 999.0, 999.0 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.632 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.98 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.849 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.613 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438 407 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.767 None DFGAsp-rot-none -90.87, -14.73 -130.14, 65.48 999.0, 999.0 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.933 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.867 APE11-dist-na 5.506 APE10-dist-na 4.99 APE9-dist-na 11.652 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438 394 10 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 12.928 None DFGAsp-rot-none -90.71, -14.62 -131.6, 64.5 999.0, 999.0 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.619 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.897 APE11-dist-na 5.471 APE10-dist-na 4.981 APE9-dist-na 11.745 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438 408 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.345 12.727 None DFGAsp-rot-none -90.69, -14.9 -130.76, 66.96 999.0, 999.0 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.686 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.886 APE11-dist-na 5.441 APE10-dist-na 4.99 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438 397 11 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.548 12.993 None DFGAsp-rot-none -92.58, -12.35 -130.21, 41.87 999.0, 999.0 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.565 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.113 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.897 APE11-dist-na 5.551 APE10-dist-na 5.004 APE9-dist-na 11.679 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438 407 7 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.634 13.143 None DFGAsp-rot-none -107.98, -0.69 -128.2, 34.36 999.0, 999.0 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.824 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.734 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.896 APE11-dist-na 5.565 APE10-dist-na 4.767 APE9-dist-na 12.093 None None None XRAY 2.59 0.185 0.221 A 438 403 9 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 13.407 None DFGAsp-rot-none -109.51, -3.14 -128.47, 33.06 999.0, 999.0 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.607 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.74 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.827 APE11-dist-na 5.687 APE10-dist-na 4.961 APE9-dist-na 11.892 None None None XRAY 2.59 0.185 0.221 B 438 412 10 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.673 13.164 None DFGAsp-rot-none -108.29, -3.21 -129.06, 34.16 999.0, 999.0 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.722 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.928 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.886 APE11-dist-na 5.663 APE10-dist-na 4.931 APE9-dist-na 11.895 None None None XRAY 2.59 0.185 0.221 C 438 404 8 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.73 13.246 None DFGAsp-rot-none -109.91, -2.89 -127.7, 32.83 999.0, 999.0 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.66 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.893 APE11-dist-na 5.689 APE10-dist-na 4.875 APE9-dist-na 11.937 None None None XRAY 2.59 0.185 0.221 D 438 411 11 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.9e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PKNG Q8NM29_CORGL 7MXBA Q8NM29 52 728 751.0 MAP:60901 Type1 Inactive DFGin 5.074 11.274 None DFGAsp-rot-in -118.68, -14.76 -87.76, 64.62 200.23, -5.01 -67.83, -34.44 189.61, 46.83 -64.01, -11.36 out-out out 16.982 Saltbr-out 16.886 HRD-in -83.43, -36.89 76.36, -45.68 out-in-in SNCoii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.58, 61.09 APE9-dihe-na -82.25, -173.13 APE8-dihe-in -124.32, 123.78 APE8-rot-in 301.48 APE67-dihe-inflip 105.13, -19.5 -60.8, 129.28 APE12-dist-in 10.91 APE11-dist-in 8.232 APE10-dist-in 5.348 APE9-dist-in 4.167 None None None XRAY 2.2 0.211 0.246 A 700 672 0 0 0 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 5e-20 78.5 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXJA Q8NM29 62 358 751.0 MAP:60502 Type1 Inactive DFGinter 6.293 10.601 None DFGAsp-rot-in -111.55, -5.33 -97.65, 70.49 198.93, -1.99 -64.68, -29.22 283.51, 177.78 -64.44, -22.13 out-out out 15.695 Saltbr-out 15.021 HRD-in -87.66, -33.88 74.73, -35.65 out-in-out SNCoio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.56, 75.8 APE9-dihe-na -90.07, -165.64 APE8-dihe-in -127.82, 123.34 APE8-rot-in 300.01 APE67-dihe-inflip 102.34, -29.53 -61.55, 136.0 APE12-dist-in 10.93 APE11-dist-out 7.83 APE10-dist-in 5.018 APE9-dist-in 3.78 None None None XRAY 1.92 0.2 0.225 A 305 285 5 0 0 0 [[104, 300]] 1.0 7mxj Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXKA Q8NM29 63 360 751.0 MAP:60502 Type1 Inactive DFGinter 6.194 10.434 None DFGAsp-rot-in -118.18, -5.51 -93.88, 67.71 200.06, -5.73 -62.41, -37.49 263.51, 7.21 -64.54, -17.14 out-out out 15.739 Saltbr-out 15.548 HRD-in -82.84, -35.3 75.7, -37.3 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.12, 60.2 APE9-dihe-na -82.13, -171.26 APE8-dihe-in -126.78, 123.26 APE8-rot-in 300.71 APE67-dihe-inflip 98.87, -23.41 -59.19, 137.58 APE12-dist-in 10.703 APE11-dist-out 7.784 APE10-dist-in 5.009 APE9-dist-in 3.749 None None None XRAY 1.99 0.21 0.237 A 305 292 6 0 0 0 [[104, 300]] 1.0 7mxk Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXBB Q8NM29 54 727 751.0 MAP:60901 Type1 Inactive DFGinter 5.205 10.811 None DFGAsp-rot-in -117.76, -14.76 -88.45, 66.45 201.61, -5.37 -66.91, -35.42 188.49, 46.74 -64.23, -11.33 out-out out 16.485 Saltbr-out 17.106 HRD-in -84.45, -36.61 76.45, -45.49 out-in-in SNCoii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.04, -21.26 APE9-dihe-na -81.14, -177.06 APE8-dihe-in -127.04, 126.21 APE8-rot-in 302.13 APE67-dihe-inflip 106.12, -20.6 -59.76, 129.82 APE12-dist-in 11.141 APE11-dist-in 9.35 APE10-dist-in 4.109 APE9-dist-in 3.755 None None None XRAY 2.2 0.211 0.246 B 700 655 8 0 0 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 5e-20 78.5 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PK1 A0A097P1P8_GVCP 6VVGA A0A097P1P8 3 279 279.0 AMP:301 ATPlike Active DFGin 9.47 12.504 BLAminus DFGAsp-rot-in -139.45, 174.39 59.11, 72.82 197.47, -13.3 -82.01, 20.88 324.49, 136.4 -73.16, -16.8 na-na na 15.471 Saltbr-na 12.976 HRD-in -69.17, -49.37 73.82, 3.86 na-in-in SNCaii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.58, 157.03 APE9-dihe-na 90.57, -158.23 APE8-dihe-in -103.25, 120.97 APE8-rot-in 311.05 APE67-dihe-in -75.71, -2.76 -55.41, -39.8 APE12-dist-in 10.799 APE11-dist-in 12.039 APE10-dist-in 6.083 APE9-dist-in 4.885 None None None XRAY 2.01 0.195 0.225 A 279 267 10 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
OTHER PK1 A0A097P1P8_GVCP 6VVGB A0A097P1P8 3 278 279.0 AMP:301 ATPlike Active DFGin 9.485 12.665 BLAminus DFGAsp-rot-in -138.4, 172.21 59.64, 73.0 198.18, -13.53 -83.58, 22.42 324.54, 137.78 -67.63, -19.86 na-na na 15.282 Saltbr-na 13.214 HRD-in -58.02, -51.7 78.84, -1.77 na-in-in SNCaii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.97, 161.51 APE9-dihe-na 88.81, -151.71 APE8-dihe-in -109.06, 113.8 APE8-rot-in 308.85 APE67-dihe-in -72.96, -2.91 -51.95, -43.87 APE12-dist-in 10.828 APE11-dist-in 12.169 APE10-dist-in 6.178 APE9-dist-in 4.697 None None None XRAY 2.01 0.195 0.225 B 279 264 12 0 0 0 [[17, 277]] 1.0 6vvg Cydia pomonella granulosis virus OTHER_PK1_GVCP CAMK 1.9e-45 161.2 8 256 249 159 160 161 163 165 49 62 66 138 140 139 141 195 183 178 177 176 175 174 173 172 92 PK-1
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.357 13.174 None DFGAsp-rot-in -145.49, -53.43 -88.36, 87.6 193.74, 7.22 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.164 APE11-dist-in 13.936 APE10-dist-out 17.359 APE9-dist-out 9.415 None None None XRAY 2.0 0.203 0.218 A 290 290 0 0 0 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.4e-138 465.4 1 265 265 224 225 226 228 230 106 120 124 199 201 200 202 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
OTHER BUBR1 A1Z6I7_DROME 6JKMA A1Z6I7 1127 1459 1460.0 ADP:61501 ATPlike Inactive DFGin 6.009 13.948 BLAminus DFGAsp-rot-in -128.73, 177.45 65.82, 73.45 191.59, 5.79 -92.38, 26.0 302.65, 107.99 -57.62, -35.04 in-in in 8.333 Saltbr-in 2.987 HRD-in -63.93, -46.09 73.48, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.755 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -54.34, 146.08 APE9-dihe-na -76.3, -56.25 APE8-dihe-in -62.83, 122.42 APE8-rot-na 191.74 APE67-dihe-in -57.79, -24.72 -57.87, -34.67 APE12-dist-in 12.122 APE11-dist-out 15.974 APE10-dist-out 12.426 APE9-dist-out 12.395 None None None XRAY 1.95 0.181 0.226 A 341 333 0 0 0 0 [[1175, 1438]] 1.0 6jkm Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.8e-133 447.7 1 265 265 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
OTHER BUBR1 A1Z6I7_DROME 6JKKA A1Z6I7 1127 1459 1460.0 No_ligand No_ligand Inactive DFGin 6.434 14.235 BLAminus DFGAsp-rot-out -129.87, 171.16 69.28, 71.46 275.26, -27.29 -92.9, 29.59 299.54, 100.4 -63.71, -26.27 in-in in 8.372 Saltbr-in 3.285 HRD-in -62.99, -44.98 76.62, -1.73 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -57.91, 126.86 APE9-dihe-na -62.83, -49.59 APE8-dihe-in -53.01, 121.9 APE8-rot-na 197.13 APE67-dihe-in -63.83, -33.44 -70.27, -27.63 APE12-dist-in 11.991 APE11-dist-out 15.94 APE10-dist-out 12.583 APE9-dist-out 12.784 None None None XRAY 1.85 0.189 0.221 A 341 333 0 0 0 0 [[1175, 1438]] 1.0 6jkk Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.8e-133 447.7 1 265 265 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
OTHER PAN3 PAN3_DROME 4BWPA Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 8.987 13.294 None DFGAsp-rot-na -64.87, -46.72 -145.48, 65.79 60.18, 999.0 -71.61, -40.0 313.19, 999.0 -67.11, -37.22 out-na out 16.832 Saltbr-na 999.0 HRD-in -50.58, -30.55 79.2, -55.76 na-out-na SNCaoa out-na ActLoopNT-out 6.698 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -83.44, -6.17 APE9-dihe-na -63.0, 138.21 APE8-dihe-na -120.41, 140.18 APE8-rot-na 194.81 APE67-dihe-na -113.46, 118.54 -59.4, -45.27 APE12-dist-na 5.306 APE11-dist-na 5.827 APE10-dist-na 8.834 APE9-dist-na 12.341 None None None XRAY 3.6 0.222 0.269 A 448 386 23 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_DROME 4BWPB Q95RR8 379 787 790.0 AN2:1788 ATPlike Pseudo DFGin 9.736 13.981 None DFGAsp-rot-na -68.02, -47.7 -135.41, 45.28 168.64, 999.0 -65.56, -36.8 296.47, 999.0 -63.81, -39.61 out-na out 16.544 Saltbr-na 999.0 HRD-in -58.26, -35.46 80.55, -56.51 na-out-na SNCaoa out-na ActLoopNT-out 5.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.2, -6.77 APE9-dihe-na -69.16, 143.64 APE8-dihe-na -96.5, 127.2 APE8-rot-na 212.33 APE67-dihe-na -115.77, 110.79 -63.6, -38.16 APE12-dist-na 4.419 APE11-dist-na 6.01 APE10-dist-na 8.854 APE9-dist-na 11.29 None None None XRAY 3.6 0.222 0.269 B 448 372 26 0 0 0 [[378, 664]] 1.0 4bwp Drosophila melanogaster OTHER_PAN3_DROME PAN3 1.2e-113 385.1 1 288 288 564 565 566 568 570 423 438 442 545 547 546 548 592 582 577 576 575 574 573 572 571 472 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER MLKL F6S337_HORSE 6VC0A F6S337 258 536 543.0 No_ligand No_ligand Pseudo DFGin 4.988 13.881 BLBminus DFGAsp-rot-none -160.47, -177.36 65.51, 36.37 999.0, 999.0 -58.39, 137.28 318.13, 86.77 58.83, -124.64 in-in in 7.643 Saltbr-in 2.677 HRD-na-E -62.53, -41.81 82.08, -6.9 in-out-out SNCioo out-out ActLoopNT-out 13.362 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -88.0, 120.78 APE9-dihe-na -72.95, 148.97 APE8-dihe-out -64.67, -29.31 APE8-rot-in 286.85 APE67-dihe-in -52.64, -29.19 -53.47, -31.2 APE12-dist-in 12.067 APE11-dist-out 17.622 APE10-dist-out 15.015 APE9-dist-out 13.613 None None None XRAY 2.746 0.175 0.238 A 292 272 7 0 0 7 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.6e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0B F6S337 258 537 543.0 No_ligand No_ligand Pseudo DFGin 5.138 14.211 BLBminus DFGAsp-rot-none -147.23, -169.43 57.25, 44.02 999.0, 999.0 -61.21, 135.2 309.04, 84.31 57.69, -129.98 in-in in 7.975 Saltbr-in 3.151 HRD-na-E -65.25, -45.35 82.07, -9.74 in-out-out SNCioo out-out ActLoopNT-out 13.481 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -126.45, 116.02 APE9-dihe-na -51.25, 124.58 APE8-dihe-out -50.77, -33.76 APE8-rot-in 297.7 APE67-dihe-in -54.8, -30.44 -56.98, -22.96 APE12-dist-none 999.0 APE11-dist-out 16.172 APE10-dist-out 15.204 APE9-dist-out 13.714 None None None XRAY 2.746 0.175 0.238 B 292 269 11 0 0 11 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.6e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER MLKL F6S337_HORSE 6VC0C F6S337 258 541 543.0 No_ligand No_ligand Pseudo DFGin 5.403 14.135 BLBminus DFGAsp-rot-none -139.49, -162.99 63.64, 39.99 999.0, 999.0 -70.44, 152.53 306.23, 102.18 57.77, 37.75 in-in in 7.883 Saltbr-in 2.77 HRD-na-E -65.22, -39.62 76.85, -6.27 in-out-out SNCioo out-out ActLoopNT-out 13.68 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.28, 135.92 APE9-dihe-na -86.15, 145.34 APE8-dihe-out -56.36, -39.87 APE8-rot-in 295.41 APE67-dihe-in -54.7, -29.08 -59.22, -20.61 APE12-dist-in 12.868 APE11-dist-out 17.817 APE10-dist-out 15.143 APE9-dist-out 13.226 None None None XRAY 2.746 0.175 0.238 C 292 271 13 0 0 8 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.6e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
OTHER AAK1 AAK1_HUMAN AF-Q2M2I8-K1A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 6.09 13.157 BLAminus DFGAsp-rot-in -130.76, 177.11 65.46, 72.88 197.28, 19.59 -86.17, 13.75 306.15, 100.85 -62.63, -26.92 in-in in 8.694 Saltbr-in 2.695 HRD-in -71.29, -40.47 67.96, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, 1.5 APE9-dihe-na -133.56, 144.49 APE8-dihe-in -85.09, 124.69 APE8-rot-in 302.03 APE67-dihe-in -65.48, -12.52 -47.91, -50.11 APE12-dist-in 12.105 APE11-dist-in 8.386 APE10-dist-in 4.177 APE9-dist-in 3.763 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[46, 313]] 1.0 AF-Q2M2I8-K1 Homo sapiens OTHER_AAK1_HUMAN OTHER 2.5e-41 147.8 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN AF-Q2M2I8-K3A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 5.909 13.37 BLAminus DFGAsp-rot-in -128.17, 175.79 57.92, 95.09 195.75, 11.93 -102.83, 15.36 298.99, 95.97 -62.48, -26.93 in-in in 8.805 Saltbr-in 2.686 HRD-in -73.71, -40.34 66.99, -5.58 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, -5.0 APE9-dihe-na -133.21, 117.79 APE8-dihe-in -58.72, 127.19 APE8-rot-in 304.31 APE67-dihe-in -63.7, -12.57 -50.37, -47.6 APE12-dist-in 12.025 APE11-dist-in 8.459 APE10-dist-in 4.129 APE9-dist-in 3.489 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[46, 313]] 1.0 AF-Q2M2I8-K3 Homo sapiens OTHER_AAK1_HUMAN OTHER 2.5e-41 147.8 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 4WSQA Q2M2I8 29 345 961.0 KSA:405 Type1 Active DFGin 6.307 13.753 BLAminus DFGAsp-rot-in -126.2, -179.67 69.61, 90.76 189.29, 6.58 -108.14, 19.69 293.57, 82.96 -69.52, -19.34 in-in in 9.524 Saltbr-in 3.051 HRD-in -67.42, -46.62 67.64, 3.19 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.1, -8.47 APE9-dihe-na -120.84, 162.67 APE8-dihe-in -101.84, 124.39 APE8-rot-in 300.18 APE67-dihe-in -59.62, -25.15 -50.19, -46.52 APE12-dist-in 12.377 APE11-dist-in 8.831 APE10-dist-in 4.474 APE9-dist-in 3.675 None None None XRAY 1.95 0.182 0.208 A 317 317 0 0 0 0 [[46, 313]] 1.0 4wsq Homo sapiens OTHER_AAK1_HUMAN OTHER 3.7e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 4WSQB Q2M2I8 33 342 961.0 KSA:404 Type1 Active DFGin 6.448 13.491 BLAminus DFGAsp-rot-in -125.14, -178.62 72.01, 91.87 192.16, 10.35 -111.17, 20.84 297.62, 84.5 -70.3, -20.72 in-in in 9.31 Saltbr-in 2.743 HRD-in -70.2, -48.3 68.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -7.92 APE9-dihe-na -118.96, 162.19 APE8-dihe-in -104.95, 123.2 APE8-rot-in 302.88 APE67-dihe-in -62.15, -24.37 -51.37, -45.33 APE12-dist-in 12.208 APE11-dist-in 8.557 APE10-dist-in 4.25 APE9-dist-in 3.744 None None None XRAY 1.95 0.182 0.208 B 317 310 0 0 0 0 [[46, 313]] 1.0 4wsq Homo sapiens OTHER_AAK1_HUMAN OTHER 3.7e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMCA Q2M2I8 34 330 961.0 YFV:401 Type1 Active DFGin 6.296 13.344 BLAminus DFGAsp-rot-in -132.35, 179.07 63.58, 102.47 196.13, -10.49 -106.53, 19.35 292.32, 96.59 -60.5, -34.69 in-in in 8.502 Saltbr-in 2.74 HRD-in -65.3, -44.13 71.44, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.27, -5.42 APE9-dihe-na -117.59, 149.82 APE8-dihe-in -99.03, 116.29 APE8-rot-in 299.63 APE67-dihe-in -50.9, -25.95 -44.55, -54.08 APE12-dist-in 12.229 APE11-dist-in 8.532 APE10-dist-in 4.19 APE9-dist-in 3.881 None None None XRAY 2.5 0.228 0.256 A 318 293 4 0 0 0 [[46, 313]] 1.0 8gmc Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMCB Q2M2I8 31 330 961.0 YFV:401 Type1 Active DFGin 6.613 13.444 BLAminus DFGAsp-rot-in -132.15, -179.67 62.85, 102.24 197.65, -11.66 -105.78, 18.46 292.58, 96.33 -60.62, -34.17 in-in in 8.465 Saltbr-in 2.937 HRD-in -65.77, -42.15 71.41, -5.73 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.13, -3.18 APE9-dihe-na -121.52, 151.08 APE8-dihe-in -97.1, 121.04 APE8-rot-in 308.13 APE67-dihe-in -59.64, -26.78 -53.61, -40.63 APE12-dist-in 12.181 APE11-dist-in 8.453 APE10-dist-in 4.154 APE9-dist-in 3.979 None None None XRAY 2.5 0.228 0.256 B 318 294 5 0 0 0 [[46, 313]] 1.0 8gmc Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMDA Q2M2I8 34 329 961.0 ZRR:401 Type1 Active DFGin 6.167 13.332 BLAminus DFGAsp-rot-in -127.52, 174.84 65.86, 97.82 199.81, -17.0 -104.03, 21.57 300.09, 93.49 -64.42, -30.01 in-in in 8.576 Saltbr-in 2.784 HRD-in -64.68, -46.09 71.69, -3.04 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.71, -15.11 APE9-dihe-na -111.33, 160.49 APE8-dihe-in -104.37, 121.78 APE8-rot-in 304.75 APE67-dihe-in -58.75, -28.21 -47.17, -46.33 APE12-dist-in 12.163 APE11-dist-in 8.434 APE10-dist-in 4.147 APE9-dist-in 3.566 None None None XRAY 2.2 0.233 0.25 A 318 294 2 0 0 0 [[46, 313]] 1.0 8gmd Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMDB Q2M2I8 29 330 961.0 ZRR:401 Type1 Active DFGin 6.372 13.478 BLAminus DFGAsp-rot-in -123.19, 179.01 67.0, 97.52 199.99, -11.05 -104.44, 17.42 296.06, 83.59 -61.74, -25.96 in-in in 8.432 Saltbr-in 2.778 HRD-in -64.58, -45.6 71.56, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.95, -11.7 APE9-dihe-na -117.06, 155.74 APE8-dihe-in -98.45, 121.78 APE8-rot-in 305.28 APE67-dihe-in -59.45, -28.48 -46.11, -46.72 APE12-dist-in 12.178 APE11-dist-in 8.374 APE10-dist-in 4.143 APE9-dist-in 3.597 None None None XRAY 2.2 0.233 0.25 B 318 299 3 0 0 0 [[46, 313]] 1.0 8gmd Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.6 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 9QB5A Q2M2I8 29 343 961.0 F7I:60401 Type1 Active DFGin 6.406 13.358 BLAminus DFGAsp-rot-in -132.26, 177.36 64.71, 93.28 193.9, 0.85 -102.58, 23.65 295.99, 87.8 -68.89, -14.08 in-in in 8.452 Saltbr-in 2.577 HRD-in -65.82, -48.18 75.53, -3.07 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.0, -10.1 APE9-dihe-na -117.28, 159.33 APE8-dihe-in -101.85, 125.23 APE8-rot-in 303.31 APE67-dihe-in -61.58, -23.49 -52.0, -46.22 APE12-dist-in 12.158 APE11-dist-in 8.502 APE10-dist-in 4.126 APE9-dist-in 3.632 None None None XRAY 2.0 0.199 0.227 A 318 313 2 0 0 0 [[46, 313]] 1.0 9qb5 Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 9QB5B Q2M2I8 34 342 961.0 F7I:60401 Type1 Active DFGin 6.457 13.039 BLAminus DFGAsp-rot-in -136.45, 178.27 73.68, 94.2 180.67, 27.95 -109.77, 25.54 300.89, 108.71 -73.91, -11.3 in-in in 8.092 Saltbr-in 2.462 HRD-in -66.48, -48.55 75.65, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.0, -6.97 APE9-dihe-na -121.88, 160.23 APE8-dihe-in -103.81, 124.81 APE8-rot-in 304.19 APE67-dihe-in -60.83, -28.74 -52.63, -42.77 APE12-dist-in 12.174 APE11-dist-in 8.578 APE10-dist-in 4.303 APE9-dist-in 3.664 None None None XRAY 2.0 0.199 0.227 B 318 309 0 0 0 0 [[46, 313]] 1.0 9qb5 Homo sapiens OTHER_AAK1_HUMAN OTHER 3.8e-41 147.5 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5L4QA Q2M2I8 33 335 961.0 LKB:401 Type1 Active DFGin 6.005 13.227 BLAminus DFGAsp-rot-in -132.85, -177.94 63.93, 92.35 189.81, -1.97 -114.27, 19.37 301.1, 98.45 -80.74, -11.63 in-in in 8.685 Saltbr-in 2.708 HRD-in -67.77, -48.62 71.48, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.55, -17.02 APE9-dihe-na -109.84, 154.17 APE8-dihe-in -96.17, 123.72 APE8-rot-in 302.79 APE67-dihe-in -62.67, -23.02 -45.97, -51.51 APE12-dist-in 11.999 APE11-dist-in 8.35 APE10-dist-in 4.067 APE9-dist-in 3.483 None None None XRAY 1.97 0.208 0.227 A 346 293 10 0 0 0 [[46, 313]] 1.0 5l4q Homo sapiens OTHER_AAK1_HUMAN OTHER 4.9e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5L4QB Q2M2I8 33 333 961.0 LKB:401 Type1 Active DFGin 6.001 13.253 BLAminus DFGAsp-rot-in -132.29, -178.13 64.06, 92.67 190.87, -1.78 -114.66, 18.46 300.35, 97.82 -80.3, -11.3 in-in in 8.565 Saltbr-in 2.714 HRD-in -67.84, -48.94 70.89, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.29, -16.57 APE9-dihe-na -109.81, 154.98 APE8-dihe-in -96.35, 124.27 APE8-rot-in 304.05 APE67-dihe-in -62.49, -22.16 -46.27, -52.25 APE12-dist-in 11.956 APE11-dist-in 8.401 APE10-dist-in 4.043 APE9-dist-in 3.505 None None None XRAY 1.97 0.208 0.227 B 346 287 14 0 0 0 [[46, 313]] 1.0 5l4q Homo sapiens OTHER_AAK1_HUMAN OTHER 4.9e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 5TE0A Q2M2I8 27 345 961.0 XIN:60401 Type1 Active DFGin 6.177 13.729 BLAminus DFGAsp-rot-in -133.95, 173.97 66.46, 103.31 204.49, -24.01 -110.15, 22.69 304.86, 94.85 -65.74, -20.86 in-in in 9.055 Saltbr-in 3.491 HRD-in -62.42, -46.29 70.69, -4.02 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -11.26 APE9-dihe-na -114.88, 156.03 APE8-dihe-in -99.05, 119.5 APE8-rot-in 300.83 APE67-dihe-in -58.27, -25.82 -45.89, -49.71 APE12-dist-in 12.141 APE11-dist-in 8.398 APE10-dist-in 4.146 APE9-dist-in 3.731 None None None XRAY 1.9 0.182 0.199 A 347 315 4 0 0 0 [[46, 313]] 1.0 5te0 Homo sapiens OTHER_AAK1_HUMAN OTHER 5e-41 147.2 3 254 252 193 194 195 197 199 74 90 94 173 175 174 176 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
OTHER BMP2K BMP2K_HUMAN 5I3OA Q9NSY1 42 343 1161.0 IDV:401 Type1 Inactive DFGin 6.008 13.446 ABAminus DFGAsp-rot-in -120.1, -5.03 -132.33, 129.9 193.19, -69.57 -127.42, 29.15 302.78, 91.82 -66.76, -26.7 in-in in 9.122 Saltbr-in 2.781 HRD-in -64.64, -49.2 69.4, 6.0 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.33, -6.45 APE9-dihe-na -125.78, 155.7 APE8-dihe-in -95.47, 122.26 APE8-rot-in 307.86 APE67-dihe-in -55.87, -33.13 -47.99, -45.79 APE12-dist-in 12.235 APE11-dist-in 8.665 APE10-dist-in 4.395 APE9-dist-in 3.771 K320A,K321A None None XRAY 2.4 0.196 0.255 A 302 302 0 0 0 0 [[51, 317]] 1.0 5i3o Homo sapiens OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3OB Q9NSY1 42 343 1161.0 IDV:401 Type1 Inactive DFGin 6.042 13.461 ABAminus DFGAsp-rot-in -120.67, -6.79 -129.61, 129.54 195.64, -72.12 -126.94, 28.43 302.96, 91.57 -62.02, -28.58 in-in in 9.101 Saltbr-in 2.753 HRD-in -66.18, -48.36 68.58, 5.95 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.19, -8.28 APE9-dihe-na -123.37, 154.68 APE8-dihe-in -93.77, 122.1 APE8-rot-in 309.24 APE67-dihe-in -54.86, -33.89 -49.2, -45.64 APE12-dist-in 12.417 APE11-dist-in 8.893 APE10-dist-in 4.391 APE9-dist-in 3.794 K320A,K321A None None XRAY 2.4 0.196 0.255 B 302 302 0 0 0 0 [[51, 317]] 1.0 5i3o Homo sapiens OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3RA Q9NSY1 42 343 1161.0 IDK:401 Type1 Inactive DFGin 6.073 13.442 ABAminus DFGAsp-rot-in -120.88, 4.16 -140.09, 134.02 200.13, -73.22 -133.38, 24.78 303.01, 88.22 -60.75, -27.07 in-in in 9.297 Saltbr-in 2.792 HRD-in -70.25, -47.7 70.76, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.8, -5.41 APE9-dihe-na -124.44, 153.57 APE8-dihe-in -93.38, 120.19 APE8-rot-in 303.38 APE67-dihe-in -56.33, -27.62 -45.73, -49.35 APE12-dist-in 12.238 APE11-dist-in 8.589 APE10-dist-in 4.319 APE9-dist-in 3.817 K320A,K321A None None XRAY 2.4 0.188 0.231 A 302 302 0 0 0 0 [[51, 317]] 1.0 5i3r Homo sapiens OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5I3RB Q9NSY1 42 343 1161.0 IDK:401 Type1 Inactive DFGin 6.078 13.533 ABAminus DFGAsp-rot-in -120.46, 2.49 -138.36, 133.12 202.54, -73.26 -133.05, 26.32 303.01, 89.8 -59.31, -28.21 in-in in 9.247 Saltbr-in 2.75 HRD-in -69.47, -46.69 69.4, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.92, -7.13 APE9-dihe-na -121.37, 153.36 APE8-dihe-in -93.4, 120.36 APE8-rot-in 304.62 APE67-dihe-in -56.13, -27.91 -46.4, -48.23 APE12-dist-in 12.26 APE11-dist-in 8.594 APE10-dist-in 4.332 APE9-dist-in 3.851 K320A,K321A None None XRAY 2.4 0.188 0.231 B 302 302 0 0 0 0 [[51, 317]] 1.0 5i3r Homo sapiens OTHER_BMP2K_HUMAN NEK 3.7e-39 140.9 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 5IKWA Q9NSY1 42 338 1161.0 6BU:4000 Type1 Inactive DFGin 6.042 13.759 ABAminus DFGAsp-rot-in -119.43, -4.98 -129.37, 129.38 185.78, -26.64 -129.09, 20.57 297.97, 99.91 -68.53, -10.14 in-in in 9.195 Saltbr-in 3.004 HRD-in -64.63, -50.21 70.81, 5.02 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.97, -10.12 APE9-dihe-na -119.45, 162.83 APE8-dihe-in -105.19, 120.82 APE8-rot-in 296.01 APE67-dihe-in -55.22, -22.41 -41.84, -57.19 APE12-dist-in 12.275 APE11-dist-in 8.615 APE10-dist-in 4.295 APE9-dist-in 3.637 K320A,K321A None None XRAY 2.41 0.178 0.216 A 310 297 0 0 0 0 [[51, 317]] 1.0 5ikw Homo sapiens OTHER_BMP2K_HUMAN NEK 4e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN AF-Q9NSY1-K1A Q9NSY1 43 325 1161.0 No_ligand No_ligand Active DFGin 6.108 13.255 BLAminus DFGAsp-rot-in -126.14, 177.99 64.0, 77.73 196.7, 19.51 -88.88, 12.98 305.14, 100.06 -61.82, -29.21 in-in in 8.805 Saltbr-in 2.708 HRD-in -70.79, -40.6 67.46, -13.46 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.33, 5.92 APE9-dihe-na -136.17, 146.78 APE8-dihe-in -87.8, 125.04 APE8-rot-in 301.53 APE67-dihe-in -64.17, -12.69 -49.11, -50.5 APE12-dist-in 12.104 APE11-dist-in 8.439 APE10-dist-in 4.181 APE9-dist-in 3.734 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[51, 317]] 1.0 AF-Q9NSY1-K1 Homo sapiens OTHER_BMP2K_HUMAN NEK 2.9e-39 141.2 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN AF-Q9NSY1-K3A Q9NSY1 43 325 1161.0 No_ligand No_ligand Active DFGin 5.933 13.381 BLAminus DFGAsp-rot-in -133.43, -179.24 58.5, 79.43 195.81, 21.06 -91.11, 12.54 300.28, 97.52 -62.53, -30.02 in-in in 8.759 Saltbr-in 2.704 HRD-in -74.93, -43.05 69.43, -12.68 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.92, 5.19 APE9-dihe-na -136.99, 142.69 APE8-dihe-in -81.51, 123.81 APE8-rot-in 305.07 APE67-dihe-in -63.69, -10.39 -48.67, -48.71 APE12-dist-in 12.009 APE11-dist-in 8.49 APE10-dist-in 4.123 APE9-dist-in 3.887 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[51, 317]] 1.0 AF-Q9NSY1-K3 Homo sapiens OTHER_BMP2K_HUMAN NEK 2.9e-39 141.2 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 4W9XA Q9NSY1 39 342 1161.0 3JW:403 Type1 Active DFGin 6.334 13.568 BLAminus DFGAsp-rot-in -134.66, 171.76 65.13, 87.84 192.64, -11.24 -97.17, 19.7 303.81, 101.33 -58.31, -30.65 in-in in 8.925 Saltbr-in 2.45 HRD-in -72.21, -49.47 77.86, -6.69 in-in-in SNCiii in-in ActLoopNT-in 2.762 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.12, -14.48 APE9-dihe-na -117.03, 162.86 APE8-dihe-in -112.23, 128.85 APE8-rot-in 299.05 APE67-dihe-in -58.38, -19.69 -56.81, -49.31 APE12-dist-in 12.23 APE11-dist-in 8.445 APE10-dist-in 4.336 APE9-dist-in 3.754 K320A,K321A None None XRAY 2.14 0.189 0.229 A 310 300 4 0 0 0 [[51, 317]] 1.0 4w9x Homo sapiens OTHER_BMP2K_HUMAN NEK 4e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BMP2K BMP2K_HUMAN 4W9WA Q9NSY1 39 344 1161.0 YDJ:401,YDJ:402 Type1,Allosteric Active DFGin 6.364 13.405 BLAminus DFGAsp-rot-in -139.2, -173.86 58.9, 80.3 195.82, -2.87 -96.98, 16.54 297.28, 103.14 -77.9, -7.86 in-in in 8.894 Saltbr-in 2.721 HRD-in -69.75, -45.92 72.53, -3.24 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.8, -11.88 APE9-dihe-na -120.42, 166.14 APE8-dihe-in -109.12, 119.34 APE8-rot-in 297.36 APE67-dihe-in -66.84, -19.57 -44.6, -50.25 APE12-dist-in 12.077 APE11-dist-in 8.332 APE10-dist-in 4.184 APE9-dist-in 3.726 K320A,K321A None None XRAY 1.72 0.168 0.195 A 306 306 0 0 0 0 [[51, 317]] 1.0 4w9w Homo sapiens OTHER_BMP2K_HUMAN NEK 3.8e-39 140.8 4 252 249 197 198 199 201 203 79 95 99 177 179 178 180 248 233 228 227 226 225 224 223 222 131 BMP-2-inducible protein kinase
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.981 12.01 BLAminus DFGAsp-rot-in -120.67, -179.49 71.42, 87.57 193.53, -7.96 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.796 Saltbr-in 2.914 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.725 APE11-dist-out 14.148 APE10-dist-out 10.635 APE9-dist-out 10.792 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356 329 15 0 0 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 4e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.101 12.046 BLAminus DFGAsp-rot-in -119.58, -176.38 67.12, 86.64 185.49, 6.11 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.772 Saltbr-in 2.901 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.697 APE11-dist-out 14.062 APE10-dist-out 10.116 APE9-dist-out 11.022 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356 328 14 0 0 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 4e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.122 11.829 BLAminus DFGAsp-rot-in -125.96, -174.79 66.73, 90.85 193.09, -10.22 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.711 Saltbr-in 2.874 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.744 APE11-dist-out 16.324 APE10-dist-out 13.204 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365 332 16 0 0 0 [[787, 1056]] 1.0 4r8q Homo sapiens OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.068 BLAminus DFGAsp-rot-in -133.45, -169.91 60.82, 85.13 199.56, -11.31 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.701 Saltbr-out 3.764 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.785 APE11-dist-out 16.036 APE10-dist-out 12.54 APE9-dist-in 5.943 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.22 11.852 BLAminus DFGAsp-rot-in -128.64, -170.27 62.18, 89.46 200.83, -8.26 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.572 Saltbr-out 4.025 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.575 APE11-dist-out 15.552 APE10-dist-out 12.266 APE9-dist-in 5.742 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.3e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN AF-O43683-K1A O43683 779 1064 1085.0 No_ligand No_ligand Inactive DFGin 4.887 12.545 BLAminus DFGAsp-rot-in -124.11, 170.92 65.03, 81.73 202.07, 5.03 -91.31, 15.98 298.54, 164.44 -67.14, -23.03 in-in in 8.046 Saltbr-in 2.67 HRD-in -69.05, -45.13 83.02, -19.12 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.71, 136.7 APE9-dihe-na -69.9, -23.95 APE8-dihe-in -86.83, 108.84 APE8-rot-in 313.14 APE67-dihe-in -72.66, -10.25 -53.96, -32.87 APE12-dist-in 11.466 APE11-dist-out 14.215 APE10-dist-out 10.259 APE9-dist-out 11.411 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[787, 1056]] 1.0 AF-O43683-K1 Homo sapiens OTHER_BUB1_HUMAN BUB 1.8e-136 459.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN AF-O43683-K3A O43683 779 1064 1085.0 No_ligand No_ligand Active DFGin 5.075 11.864 BLAminus DFGAsp-rot-in -128.54, -179.59 61.18, 57.25 201.6, 27.47 -71.97, 12.64 306.02, 171.57 -71.12, -26.04 in-in in 7.607 Saltbr-in 2.673 HRD-in -71.31, -42.36 83.29, -4.71 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -66.95, 155.76 APE9-dihe-na -65.62, -39.37 APE8-dihe-in -84.2, 100.84 APE8-rot-in 321.71 APE67-dihe-in -71.04, -6.24 -56.45, -33.95 APE12-dist-in 11.484 APE11-dist-in 12.195 APE10-dist-in 6.713 APE9-dist-in 4.093 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[787, 1056]] 1.0 AF-O43683-K3 Homo sapiens OTHER_BUB1_HUMAN BUB 1.8e-136 459.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 6F7BA O43683 733 1083 1085.0 CVQ:1101 Type1 Inactive DFGin 5.204 11.398 BLAminus DFGAsp-rot-in -126.36, -174.36 69.54, 95.46 197.32, -30.64 -102.79, 20.07 303.33, 2.4 -61.63, -33.57 in-in in 7.39 Saltbr-in 2.854 HRD-in -67.06, -52.34 92.92, -9.99 in-in-out SNCiio in-out ActLoopNT-in 2.884 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iioo APE10-dihe-na -74.7, 171.94 APE9-dihe-na -80.48, 177.67 APE8-dihe-out -47.35, -47.06 APE8-rot-in 327.35 APE67-dihe-out -87.96, 156.59 -88.9, -3.15 APE12-dist-in 11.273 APE11-dist-in 13.096 APE10-dist-out 8.947 APE9-dist-out 8.054 None SEP969 SEP969 XRAY 2.0 0.201 0.254 A 361 343 8 0 0 0 [[787, 1056]] 1.0 6f7b Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus DFGAsp-rot-in -125.0, 176.56 71.88, 86.33 191.14, -10.66 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus DFGAsp-rot-in -128.61, 175.54 70.41, 87.99 191.32, -8.92 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus DFGAsp-rot-in -118.89, -178.58 68.69, 81.33 193.06, -3.59 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus DFGAsp-rot-in -126.02, 169.07 75.11, 84.03 194.62, -1.51 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus DFGAsp-rot-in -118.93, 173.08 76.34, 83.66 188.96, -2.47 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN AF-O00311-K1A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.95 14.177 BLAminus DFGAsp-rot-in -129.58, 170.96 66.26, 66.12 197.59, 20.89 -80.51, 16.59 285.96, 75.59 -64.0, -18.9 in-in in 9.043 Saltbr-in 2.647 HRD-in -70.08, -43.27 61.9, 11.94 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -57.06, 169.65 APE9-dihe-na -22.62, -165.28 APE8-dihe-in -75.42, 125.22 APE8-rot-in 295.02 APE67-dihe-inflip 114.52, -42.17 -51.79, 128.13 APE12-dist-in 7.28 APE11-dist-in 10.794 APE10-dist-in 6.853 APE9-dist-in 4.125 None None None AF2 -1.0 1.0 1.0 A 525 525 0 0 0 0 [[58, 569]] 1.0 AF-O00311-K1 Homo sapiens OTHER_CDC7_HUMAN CAMK 1.9e-16 136.0 1 154 259 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN AF-O00311-K3A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.672 14.126 BLAminus DFGAsp-rot-in -130.86, 172.4 65.31, 69.78 197.55, 8.09 -80.97, 15.05 291.64, 76.67 -63.99, -19.66 in-in in 9.106 Saltbr-in 2.648 HRD-in -70.9, -38.36 68.14, -18.59 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -62.79, 152.01 APE9-dihe-na 121.05, 152.26 APE8-dihe-in -66.89, 133.21 APE8-rot-in 295.57 APE67-dihe-inflip 90.18, -22.02 -52.1, 138.77 APE12-dist-in 9.078 APE11-dist-in 11.232 APE10-dist-in 5.336 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 525 525 0 0 0 0 [[58, 569]] 1.0 AF-O00311-K3 Homo sapiens OTHER_CDC7_HUMAN CAMK 1.9e-16 136.0 1 154 259 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.763 14.014 BLAminus DFGAsp-rot-in -127.87, 167.58 73.15, 98.39 210.16, -36.47 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.088 Saltbr-in 2.963 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361 318 38 0 0 17 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.596 14.137 BLAminus DFGAsp-rot-in -121.21, 173.13 67.81, 82.77 213.16, -38.5 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.886 Saltbr-in 2.749 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361 316 42 0 0 21 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.868 14.2 BLAminus DFGAsp-rot-in -130.13, 163.69 79.42, 87.08 198.91, -9.59 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.697 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361 306 48 0 0 26 [[58, 569]] 1.0 4f9c Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.683 14.123 BLAminus DFGAsp-rot-in -124.62, 164.87 81.15, 86.75 201.51, -13.15 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.653 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.586 None None None XRAY 1.44 0.168 0.193 A 359 340 12 0 0 12 [[58, 569]] 1.0 6ya6 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CHUK IKKA_HUMAN AF-O15111-K1A O15111 7 317 745.0 No_ligand No_ligand Active DFGin 5.704 12.09 BLAminus DFGAsp-rot-in -127.62, 177.04 62.52, 68.46 196.03, 22.32 -82.08, 19.91 301.08, 3.12 -65.11, -21.3 in-in in 8.279 Saltbr-in 2.599 HRD-in -74.14, -49.8 66.35, 2.91 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.32, 159.76 APE9-dihe-na 113.86, -177.42 APE8-dihe-in -101.61, 123.11 APE8-rot-in 299.17 APE67-dihe-in -65.21, -21.74 -44.12, -40.19 APE12-dist-in 8.574 APE11-dist-in 11.217 APE10-dist-in 5.335 APE9-dist-in 3.343 None None None AF2 -1.0 1.0 1.0 A 311 311 0 0 0 0 [[15, 294]] 1.0 AF-O15111-K1 Homo sapiens OTHER_CHUK_HUMAN OTHER 9.2e-53 185.4 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN AF-O15111-K3A O15111 7 317 745.0 No_ligand No_ligand Active DFGin 5.793 12.319 BLAminus DFGAsp-rot-in -129.7, 178.58 58.9, 65.09 195.18, 26.45 -77.77, 19.68 299.27, 6.24 -65.69, -21.41 in-in in 8.238 Saltbr-in 2.618 HRD-in -75.09, -46.34 64.31, 13.49 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.99, 156.79 APE9-dihe-na 112.3, -173.76 APE8-dihe-in -103.27, 125.01 APE8-rot-in 297.57 APE67-dihe-in -71.46, -14.09 -48.66, -37.2 APE12-dist-in 8.266 APE11-dist-in 11.217 APE10-dist-in 5.322 APE9-dist-in 3.308 None None None AF2 -1.0 1.0 1.0 A 311 311 0 0 0 0 [[15, 294]] 1.0 AF-O15111-K3 Homo sapiens OTHER_CHUK_HUMAN OTHER 9.2e-53 185.4 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZA O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.472 12.995 BLAminus DFGAsp-rot-in -157.9, 159.21 63.36, 117.08 181.84, 52.17 -127.05, 13.58 301.36, 131.68 -58.14, 0.46 in-out in 8.384 Saltbr-out 3.935 HRD-out -106.09, 98.92 -80.08, -31.47 out-in-out SNCoio in-out ActLoopNT-in 2.724 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiio APE10-dihe-na -133.13, -142.71 APE9-dihe-na -132.24, 138.03 APE8-dihe-out 32.05, 63.16 APE8-rot-out 173.72 APE67-dihe-out -166.38, -24.98 -61.08, 149.09 APE12-dist-in 9.604 APE11-dist-in 10.391 APE10-dist-in 7.45 APE9-dist-out 11.556 S176E,S180E None None XRAY 4.5 0.238 0.276 A 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZB O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.556 13.063 BLAminus DFGAsp-rot-in -157.87, 159.26 63.18, 117.0 181.73, 52.42 -127.43, 13.74 302.04, 131.95 -63.43, -5.84 in-out in 8.377 Saltbr-out 3.932 HRD-out -105.04, 98.56 -80.0, -30.69 out-in-out SNCoio in-out ActLoopNT-in 2.712 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -120.36, -131.93 APE9-dihe-na -142.0, 138.99 APE8-dihe-out 48.95, 36.51 APE8-rot-in 319.88 APE67-dihe-out -168.68, -36.55 -40.64, 144.07 APE12-dist-in 9.276 APE11-dist-in 10.073 APE10-dist-in 7.128 APE9-dist-out 11.466 S176E,S180E None None XRAY 4.5 0.238 0.276 B 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZC O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.349 12.937 BLAminus DFGAsp-rot-in -158.04, 158.83 63.52, 116.84 181.29, 51.64 -127.52, 13.57 301.17, 131.76 -63.04, -7.12 in-out in 8.378 Saltbr-out 3.924 HRD-out -105.78, 98.7 -80.36, -30.84 out-in-out SNCoio in-out ActLoopNT-in 3.083 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -114.04, -134.54 APE9-dihe-na -154.94, 140.93 APE8-dihe-out 52.3, 55.69 APE8-rot-in 310.3 APE67-dihe-inflip 179.0, -28.48 -76.67, 159.59 APE12-dist-in 8.462 APE11-dist-in 9.618 APE10-dist-in 6.882 APE9-dist-out 11.735 S176E,S180E None None XRAY 4.5 0.238 0.276 C 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZD O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.446 12.996 BLAminus DFGAsp-rot-in -157.99, 158.75 63.84, 116.89 181.5, 52.27 -127.2, 14.28 302.16, 131.35 -61.31, -3.61 in-out in 8.38 Saltbr-out 3.942 HRD-out -104.7, 98.61 -80.36, -30.78 out-in-out SNCoio in-out ActLoopNT-in 3.323 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiio APE10-dihe-na -114.92, -87.2 APE9-dihe-na 172.15, 150.56 APE8-dihe-out 44.69, 73.14 APE8-rot-out 59.12 APE67-dihe-out -173.33, -15.3 -88.22, 143.81 APE12-dist-in 9.76 APE11-dist-in 10.399 APE10-dist-in 6.858 APE9-dist-out 11.578 S176E,S180E None None XRAY 4.5 0.238 0.276 D 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZE O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.413 12.963 BLAminus DFGAsp-rot-in -157.88, 159.1 63.37, 117.32 181.66, 52.28 -127.83, 12.95 301.29, 131.92 -62.78, -6.6 in-out in 8.378 Saltbr-out 3.94 HRD-out -105.55, 98.72 -80.22, -30.93 out-in-out SNCoio in-out ActLoopNT-in 2.615 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -101.36, -137.17 APE9-dihe-na -137.48, 131.52 APE8-dihe-out 54.15, 65.61 APE8-rot-in 305.76 APE67-dihe-inflip 177.55, -22.94 -67.74, 156.35 APE12-dist-in 9.29 APE11-dist-in 10.41 APE10-dist-in 7.028 APE9-dist-out 11.537 S176E,S180E None None XRAY 4.5 0.238 0.276 E 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZF O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.554 12.956 BLAminus DFGAsp-rot-in -158.13, 160.12 61.88, 117.06 181.32, 53.41 -126.71, 13.37 301.67, 131.82 -61.28, -5.01 in-out in 8.368 Saltbr-out 3.921 HRD-out -104.83, 98.57 -80.32, -31.25 out-in-out SNCoio in-out ActLoopNT-in 2.648 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -133.95, -55.57 APE9-dihe-na 135.71, 126.78 APE8-dihe-out 52.92, 17.09 APE8-rot-in 348.87 APE67-dihe-out -130.03, -5.11 -48.71, 131.65 APE12-dist-in 9.462 APE11-dist-in 9.851 APE10-dist-in 7.027 APE9-dist-out 11.892 S176E,S180E None None XRAY 4.5 0.238 0.276 F 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZG O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.563 13.038 BLAminus DFGAsp-rot-in -157.79, 159.24 63.47, 116.86 181.68, 51.76 -127.13, 13.59 300.88, 131.93 -60.03, -2.91 in-out in 8.374 Saltbr-out 3.937 HRD-out -105.82, 98.69 -80.11, -31.24 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -105.14, -87.49 APE9-dihe-na -173.89, 131.61 APE8-dihe-out 42.38, 74.45 APE8-rot-in 310.05 APE67-dihe-out -155.35, -14.77 -78.11, 142.24 APE12-dist-in 8.133 APE11-dist-in 10.133 APE10-dist-in 7.365 APE9-dist-out 11.77 S176E,S180E None None XRAY 4.5 0.238 0.276 G 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZH O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.623 12.928 BLAminus DFGAsp-rot-in -157.82, 159.2 63.3, 117.1 182.19, 52.23 -127.62, 13.57 302.64, 131.85 -66.21, -13.0 in-out in 8.378 Saltbr-out 3.921 HRD-out -105.33, 98.48 -79.98, -30.79 out-in-out SNCoio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -120.33, -132.08 APE9-dihe-na -135.18, 141.74 APE8-dihe-out 53.01, 41.79 APE8-rot-in 318.66 APE67-dihe-out -179.07, -65.81 -56.31, 151.34 APE12-dist-in 9.028 APE11-dist-in 10.229 APE10-dist-in 6.71 APE9-dist-out 11.904 S176E,S180E None None XRAY 4.5 0.238 0.276 H 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZI O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.447 12.905 BLAminus DFGAsp-rot-in -158.21, 159.53 62.55, 117.44 181.19, 51.85 -127.53, 13.64 301.73, 131.69 -61.68, -3.37 in-out in 8.378 Saltbr-out 3.928 HRD-out -105.58, 98.9 -80.55, -30.56 out-in-out SNCoio in-out ActLoopNT-in 2.614 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiio APE10-dihe-na -123.2, -168.23 APE9-dihe-na -65.65, -161.64 APE8-dihe-in -47.13, 90.76 APE8-rot-in 294.26 APE67-dihe-out -155.06, -11.93 -74.74, 142.39 APE12-dist-in 7.733 APE11-dist-in 9.24 APE10-dist-in 7.259 APE9-dist-out 12.113 S176E,S180E None None XRAY 4.5 0.238 0.276 I 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZJ O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.457 13.035 BLAminus DFGAsp-rot-in -158.14, 158.87 63.49, 116.94 181.48, 52.74 -127.22, 13.75 301.97, 131.59 -63.14, -6.87 in-out in 8.378 Saltbr-out 3.95 HRD-out -104.47, 97.82 -79.51, -30.99 out-in-out SNCoio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -134.95, -77.48 APE9-dihe-na 163.8, 138.53 APE8-dihe-out 51.98, 77.04 APE8-rot-in 309.05 APE67-dihe-out -176.04, -11.28 -80.48, 141.14 APE12-dist-in 8.844 APE11-dist-in 9.965 APE10-dist-in 6.813 APE9-dist-out 11.672 S176E,S180E None None XRAY 4.5 0.238 0.276 J 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZK O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.446 12.97 BLAminus DFGAsp-rot-in -158.43, 159.6 63.23, 117.12 181.6, 52.38 -127.98, 13.19 301.21, 131.48 -63.15, -8.18 in-out in 8.379 Saltbr-out 3.906 HRD-out -105.38, 98.71 -80.39, -31.17 out-in-out SNCoio in-out ActLoopNT-in 2.584 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -113.74, -140.48 APE9-dihe-na -132.51, 126.65 APE8-dihe-out 53.41, 74.49 APE8-rot-in 305.2 APE67-dihe-inflip 170.32, -23.62 -76.67, 162.92 APE12-dist-in 8.511 APE11-dist-in 10.095 APE10-dist-in 7.401 APE9-dist-out 11.867 S176E,S180E None None XRAY 4.5 0.238 0.276 K 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5EBZL O15111 10 660 745.0 5TL:60701 Type1 Inactive DFGin 6.521 12.989 BLAminus DFGAsp-rot-in -158.24, 159.63 62.65, 117.16 181.43, 52.8 -127.45, 13.49 301.65, 131.79 -64.73, -7.71 in-out in 8.372 Saltbr-out 3.931 HRD-out -104.64, 98.46 -80.27, -31.08 out-in-out SNCoio in-out ActLoopNT-in 2.617 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiio APE10-dihe-na -118.73, -95.08 APE9-dihe-na -177.7, 127.99 APE8-dihe-out 49.93, 69.03 APE8-rot-in 331.03 APE67-dihe-out -153.57, -29.29 -80.56, 145.25 APE12-dist-in 9.335 APE11-dist-in 10.03 APE10-dist-in 6.77 APE9-dist-out 11.862 S176E,S180E None None XRAY 4.5 0.238 0.276 L 655 651 0 0 0 0 [[15, 294]] 1.0 5ebz Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQWA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -121.53, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.695 Saltbr-in 2.516 HRD-in -73.2, -34.98 65.9, 2.16 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.08, -10.54 999.0, -7.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.6 999.0 999.0 A 655 564 59 0 0 20 [[15, 294]] 1.0 5tqw Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQWB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -121.68, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.693 Saltbr-in 2.517 HRD-in -73.21, -34.93 65.98, 2.06 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.08, -10.48 999.0, -7.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.6 999.0 999.0 B 655 564 59 0 0 20 [[15, 294]] 1.0 5tqw Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQXA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -93.75, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.51 Saltbr-out 4.44 HRD-in -71.13, -57.89 73.32, -12.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.71 APE8-rot-in 303.99 APE67-dihe-in -76.84, -13.71 -97.01, -2.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.4 999.0 999.0 A 655 563 54 0 0 19 [[15, 294]] 1.0 5tqx Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQXB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -93.81, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 8.51 Saltbr-out 4.44 HRD-in -71.08, -57.92 73.39, -12.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 106.81 APE8-rot-in 303.97 APE67-dihe-in -76.86, -13.71 -97.1, -2.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.4 999.0 999.0 B 655 563 54 0 0 19 [[15, 294]] 1.0 5tqx Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQYA O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -144.19, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.281 Saltbr-out 4.528 HRD-in -72.53, -37.92 60.97, 11.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.38 APE8-rot-in 301.07 APE67-dihe-in -70.69, -23.59 -103.74, -19.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.2 999.0 999.0 A 655 578 54 0 0 19 [[15, 294]] 1.0 5tqy Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER CHUK IKKA_HUMAN 5TQYB O15111 14 660 745.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -144.13, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 9.279 Saltbr-out 4.527 HRD-in -72.66, -37.87 60.82, 11.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.32 APE8-rot-in 301.16 APE67-dihe-in -70.79, -23.46 -103.64, -19.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S176E,S180E None None EM 5.2 999.0 999.0 B 655 578 54 0 0 19 [[15, 294]] 1.0 5tqy Homo sapiens OTHER_CHUK_HUMAN OTHER 1.5e-51 182.3 1 250 250 164 165 166 168 170 44 61 65 141 143 142 144 203 191 186 185 184 183 182 181 180 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha
OTHER DSTYK DUSTY_HUMAN AF-Q6XUX3-K1A Q6XUX3 644 916 929.0 No_ligand No_ligand Active DFGin 5.525 12.5 BLAminus DFGAsp-rot-in -135.67, 179.03 67.7, 62.8 200.07, 17.92 -81.0, 10.29 308.22, 7.96 -62.27, -25.9 in-in in 7.924 Saltbr-in 2.675 HRD-in -75.72, -44.19 63.93, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 165.0 APE9-dihe-na 103.92, -178.75 APE8-dihe-in -87.6, 119.49 APE8-rot-in 302.61 APE67-dihe-in -66.26, -22.08 -47.21, -45.97 APE12-dist-in 8.664 APE11-dist-in 11.304 APE10-dist-in 5.516 APE9-dist-in 3.575 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[650, 908]] 1.0 AF-Q6XUX3-K1 Homo sapiens OTHER_DSTYK_HUMAN TKL 4.5e-37 134.0 4 265 262 794 795 796 798 800 681 697 701 774 776 775 777 830 819 814 813 812 811 810 809 808 735 Dual serine/threonine and tyrosine protein kinase
OTHER DSTYK DUSTY_HUMAN AF-Q6XUX3-K3A Q6XUX3 644 916 929.0 No_ligand No_ligand Active DFGin 5.506 12.526 BLAminus DFGAsp-rot-in -132.96, 175.33 65.47, 65.66 198.45, 21.81 -74.76, 15.89 304.88, 8.41 -60.99, -23.72 in-in in 8.906 Saltbr-in 2.689 HRD-in -76.85, -43.91 65.27, 12.2 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.43, 159.06 APE9-dihe-na 120.99, 175.91 APE8-dihe-in -84.2, 123.32 APE8-rot-in 299.52 APE67-dihe-in -64.52, -20.37 -51.46, -48.2 APE12-dist-in 8.578 APE11-dist-in 11.601 APE10-dist-in 5.723 APE9-dist-in 3.444 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[650, 908]] 1.0 AF-Q6XUX3-K3 Homo sapiens OTHER_DSTYK_HUMAN TKL 4.5e-37 134.0 4 265 262 794 795 796 798 800 681 697 701 774 776 775 777 830 819 814 813 812 811 810 809 808 735 Dual serine/threonine and tyrosine protein kinase
OTHER EIF2AK1 E2AK1_HUMAN AF-Q9BQI3-K1A Q9BQI3 159 591 630.0 No_ligand No_ligand Active DFGin 6.467 14.562 BLAminus DFGAsp-rot-in -131.92, -174.96 56.89, 76.47 193.78, 24.76 -88.07, 19.13 289.41, 80.9 -58.96, -27.63 in-in in 8.537 Saltbr-in 2.718 HRD-in -71.02, -44.85 67.31, -7.29 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.67, 162.49 APE9-dihe-na 93.82, 165.11 APE8-dihe-in -70.82, 124.42 APE8-rot-in 291.15 APE67-dihe-in -57.27, -28.02 -49.56, -44.59 APE12-dist-in 9.1 APE11-dist-in 11.857 APE10-dist-in 5.935 APE9-dist-in 3.646 None None None AF2 -1.0 1.0 1.0 A 433 433 0 0 0 0 [[48, 583]] 1.0 AF-Q9BQI3-K1 Homo sapiens OTHER_EIF2AK1_HUMAN OTHER 1.2e-45 162.1 1 257 257 460 461 462 464 466 196 214 218 439 441 440 442 512 500 495 494 493 492 491 490 489 385 Eukaryotic translation initiation factor 2-alpha kinase 1
OTHER EIF2AK1 E2AK1_HUMAN AF-Q9BQI3-K3A Q9BQI3 159 591 630.0 No_ligand No_ligand Active DFGin 6.361 14.345 BLAminus DFGAsp-rot-in -137.24, -170.89 57.0, 58.15 193.79, 30.25 -73.48, 14.84 291.76, 88.74 -60.41, -27.06 in-in in 7.764 Saltbr-in 2.688 HRD-in -75.49, -42.3 67.07, -9.68 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.29, 159.56 APE9-dihe-na 101.23, 170.11 APE8-dihe-in -77.19, 124.48 APE8-rot-in 287.94 APE67-dihe-in -60.9, -28.79 -48.13, -43.53 APE12-dist-in 9.105 APE11-dist-in 11.94 APE10-dist-in 5.966 APE9-dist-in 3.402 None None None AF2 -1.0 1.0 1.0 A 433 433 0 0 0 0 [[48, 583]] 1.0 AF-Q9BQI3-K3 Homo sapiens OTHER_EIF2AK1_HUMAN OTHER 1.2e-45 162.1 1 257 257 460 461 462 464 466 196 214 218 439 441 440 442 512 500 495 494 493 492 491 490 489 385 Eukaryotic translation initiation factor 2-alpha kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.285 14.335 ABAminus DFGAsp-rot-in -120.94, -28.83 -115.8, 107.84 178.61, -4.62 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.248 Saltbr-in 2.731 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.545 APE11-dist-in 10.841 APE10-dist-out 10.336 APE9-dist-out 9.852 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284 262 9 0 0 0 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.941 14.558 ABAminus DFGAsp-rot-in -118.27, -31.05 -99.56, 112.7 206.74, -13.64 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.696 Saltbr-in 3.422 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284 202 69 0 0 22 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A1AB P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.258 14.04 ABAminus DFGAsp-rot-in -132.54, 38.21 -152.54, 121.76 182.44, -61.28 -125.72, 22.12 289.52, 72.9 -59.14, -10.25 in-in in 8.628 Saltbr-in 2.676 HRD-out -113.12, 112.61 -109.71, 52.22 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -135.52, 146.24 APE9-dihe-na 84.2, -133.27 APE8-dihe-in -88.04, 112.57 APE8-rot-out 53.95 APE67-dihe-out -49.6, 148.63 -66.06, -24.41 APE12-dist-in 12.721 APE11-dist-in 10.235 APE10-dist-out 9.499 APE9-dist-out 9.747 H412N,C551A TPO446 TPO446 XRAY 2.8 0.213 0.268 B 284 267 4 0 0 0 [[175, 537]] 1.0 2a1a Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.4e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 8QELB P19525 258 541 551.0 UH3:64000 Type1 Inactive DFGin 6.691 13.817 ABAminus DFGAsp-rot-in -110.21, -37.78 -88.63, 117.61 196.31, -68.21 -118.7, 28.42 293.93, 84.05 -65.21, -26.2 in-in in 8.639 Saltbr-in 3.087 HRD-in -74.4, -47.11 71.83, -9.65 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -148.0, 101.41 APE9-dihe-na -176.3, -150.32 APE8-dihe-out -87.07, -2.65 APE8-rot-out 19.95 APE67-dihe-out -74.94, -36.92 29.55, 28.82 APE12-dist-in 12.883 APE11-dist-in 10.587 APE10-dist-out 11.133 APE9-dist-out 9.144 None TPO446 TPO446 XRAY 2.451 0.243 0.278 B 273 265 0 0 0 0 [[175, 537]] 1.0 8qel Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 5.5e-47 166.5 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.192 14.114 BLAminus DFGAsp-rot-in -129.83, -165.99 54.1, 79.73 201.48, -12.86 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.721 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323 258 31 0 0 10 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.393 14.221 BLAminus DFGAsp-rot-in -124.42, -164.03 49.77, 78.4 198.3, 27.26 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.57 Saltbr-in 2.966 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323 254 33 0 0 11 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.312 14.466 BLAminus DFGAsp-rot-in -121.59, -161.34 59.64, 70.11 199.97, -2.68 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.513 Saltbr-in 2.676 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.194 None None None XRAY 2.6 0.212 0.266 C 323 258 27 0 0 3 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN AF-P19525-K1A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.333 13.834 BLAminus DFGAsp-rot-in -132.8, -166.15 52.16, 75.52 192.27, 27.15 -88.26, 20.77 290.79, 85.32 -63.1, -19.58 in-in in 8.478 Saltbr-in 2.736 HRD-in -72.57, -46.6 69.03, -13.92 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.51, 128.47 APE9-dihe-na 130.95, 179.51 APE8-dihe-in -75.68, 113.45 APE8-rot-in 288.39 APE67-dihe-in -56.2, -32.95 -49.38, -38.3 APE12-dist-in 12.505 APE11-dist-in 12.584 APE10-dist-in 6.947 APE9-dist-in 4.405 None None None AF2 -1.0 1.0 1.0 A 288 288 0 0 0 0 [[175, 537]] 1.0 AF-P19525-K1 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 2.4e-49 174.3 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN AF-P19525-K3A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.437 14.688 BLAminus DFGAsp-rot-in -132.88, -162.16 46.57, 66.9 192.82, 16.79 -77.63, 15.78 288.57, 86.29 -62.83, -24.06 in-in in 8.245 Saltbr-in 2.727 HRD-in -72.61, -45.07 68.66, -19.19 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.26, 124.49 APE9-dihe-na 137.76, -176.2 APE8-dihe-in -86.4, 108.58 APE8-rot-in 306.54 APE67-dihe-in -53.8, -42.4 -49.39, -37.75 APE12-dist-in 12.581 APE11-dist-in 12.645 APE10-dist-in 7.186 APE9-dist-in 4.589 None None None AF2 -1.0 1.0 1.0 A 288 288 0 0 0 0 [[175, 537]] 1.0 AF-P19525-K3 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 2.4e-49 174.3 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.428 13.548 None DFGAsp-rot-in -156.44, 50.2 -150.13, 79.38 189.81, 66.6 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.25 Saltbr-out 4.208 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.893 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323 248 36 0 0 17 [[175, 537]] 1.0 6d3l Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.6e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.617 12.224 None DFGAsp-rot-in 179.67, 47.65 -88.7, 86.35 174.89, -87.02 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.54 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306 255 33 0 0 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.4e-48 170.6 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.613 12.222 None DFGAsp-rot-in 179.62, 47.59 -88.43, 86.11 174.81, -86.51 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.534 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306 255 33 0 0 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.4e-48 170.6 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K1A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.869 13.858 BLAminus DFGAsp-rot-in -144.99, -173.94 54.37, 67.55 195.8, 29.23 -75.34, 20.54 292.33, 90.53 -60.73, -19.34 in-in in 9.132 Saltbr-in 2.703 HRD-in -81.34, -41.96 64.36, -15.0 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.8, 151.1 APE9-dihe-na 99.93, 176.91 APE8-dihe-in -81.29, 119.6 APE8-rot-in 301.9 APE67-dihe-in -78.31, -22.78 -45.12, -27.42 APE12-dist-in 11.098 APE11-dist-in 12.405 APE10-dist-in 6.445 APE9-dist-in 3.677 None None None AF2 -1.0 1.0 1.0 A 501 501 0 0 0 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K1 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN AF-Q9NZJ5-K3A Q9NZJ5 585 1085 1116.0 No_ligand No_ligand Active DFGin 6.608 13.733 BLAminus DFGAsp-rot-in -140.91, -171.67 54.11, 63.74 192.44, 25.28 -75.27, 21.29 296.22, 91.12 -60.87, -20.0 in-in in 8.242 Saltbr-in 2.671 HRD-in -80.93, -43.84 66.73, -9.25 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.59, 135.8 APE9-dihe-na 120.91, -171.05 APE8-dihe-in -91.04, 118.7 APE8-rot-in 298.86 APE67-dihe-in -66.86, -27.92 -47.06, -34.99 APE12-dist-in 11.278 APE11-dist-in 12.376 APE10-dist-in 6.478 APE9-dist-in 3.488 None None None AF2 -1.0 1.0 1.0 A 501 501 0 0 0 0 [[593, 1077]] 1.0 AF-Q9NZJ5-K3 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7OA Q9NZJ5 585 1081 1116.0 3Z6:1101 Type1 Inactive DFGin 6.341 13.643 None DFGAsp-rot-in -94.22, -155.12 -53.25, 136.69 200.25, -7.41 -155.12, 166.24 66.84, 102.95 73.29, 999.0 out-out out 12.524 Saltbr-out 8.569 HRD-in -83.31, -58.9 75.59, 7.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.73 APE8-rot-out 177.5 APE67-dihe-in -54.31, -34.32 -114.42, 10.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.65 0.2 0.226 A 317 246 46 0 0 29 [[593, 1077]] 1.0 4x7o Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 7MF0AAA Q9NZJ5 586 1080 1116.0 Z6P:61101 Type1 Inactive DFGin 6.095 13.784 None DFGAsp-rot-in -77.51, -156.87 -60.47, 147.45 210.9, -12.28 -172.68, 155.23 76.53, 99.05 77.56, 168.51 out-out out 12.728 Saltbr-out 8.739 HRD-in -96.15, -47.28 50.09, 33.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.24 APE8-rot-out 176.88 APE67-dihe-in -78.52, -21.92 -131.22, 23.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.809 0.234 0.273 AAA 317 259 31 0 0 27 [[593, 1077]] 1.0 7mf0 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQ9AAA Q9NZJ5 585 1080 1116.0 WPB:1101 Type1 Inactive DFGin 6.336 13.342 None DFGAsp-rot-in -89.55, -152.51 -63.21, 140.56 205.29, 2.12 -148.5, 177.54 60.71, 99.01 64.9, 170.78 out-out out 12.699 Saltbr-out 8.372 HRD-in -76.32, -70.44 74.66, 17.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 156.68 APE8-rot-out 169.43 APE67-dihe-in -67.45, -23.48 -135.96, 8.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.86 0.241 0.277 AAA 317 253 38 0 0 27 [[593, 1077]] 1.0 8eq9 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQDAAA Q9NZJ5 585 1080 1116.0 WPX:1101 Type1 Inactive DFGin 6.511 13.393 None DFGAsp-rot-in -76.6, -162.05 -50.39, 140.83 192.64, 5.81 -163.18, 172.47 74.08, 87.8 62.7, 177.79 out-out out 12.954 Saltbr-out 8.092 HRD-in -67.23, -62.02 65.5, 23.69 out-out-out SNCooo out-out ActLoopNT-out 11.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.26 APE8-rot-out 186.47 APE67-dihe-in -80.59, -35.16 -113.72, 25.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.92 0.248 0.28 AAA 317 256 35 0 0 25 [[593, 1077]] 1.0 8eqd Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G31A Q9NZJ5 588 1080 1116.0 0WH:61102 Type1.5_Back Inactive DFGin 6.232 13.832 None DFGAsp-rot-in -84.54, -159.02 -56.0, 133.56 191.31, 12.36 -155.02, 170.5 66.17, 105.5 78.35, 175.83 out-out out 13.061 Saltbr-out 9.7 HRD-in -87.72, -55.13 80.73, -18.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.1 APE8-dihe-in -65.54, 146.89 APE8-rot-out 180.58 APE67-dihe-in -54.55, -32.6 -106.33, 6.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.304 None None None XRAY 2.28 0.205 0.242 A 299 247 38 0 0 26 [[593, 1077]] 1.0 4g31 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4G34A Q9NZJ5 588 1079 1116.0 924:61101 Type1.5_Back Inactive DFGin 6.097 13.68 None DFGAsp-rot-in -82.87, -161.08 -56.81, 138.38 196.42, 9.09 -162.6, 172.39 72.3, 101.28 108.73, -50.4 out-out out 12.692 Saltbr-out 9.767 HRD-in -88.56, -52.58 79.71, -18.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.81 APE8-dihe-in -70.71, 157.12 APE8-rot-out 46.57 APE67-dihe-in -60.9, -30.41 -107.3, 13.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 None None None XRAY 2.7 0.21 0.258 A 299 247 37 0 0 27 [[593, 1077]] 1.0 4g34 Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4M7IA Q9NZJ5 588 1080 1116.0 27D:61101 Type1.5_Back Inactive DFGin 6.029 13.826 None DFGAsp-rot-in -84.66, -156.85 -61.94, 137.1 187.96, 19.34 -158.49, 171.52 68.59, 102.9 119.66, -36.59 out-out out 12.789 Saltbr-out 10.758 HRD-in -87.5, -55.06 77.0, -17.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.52 APE8-dihe-in -64.41, 144.81 APE8-rot-out 183.67 APE67-dihe-in -62.47, -30.87 -109.76, 13.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.135 None None None XRAY 2.34 0.209 0.282 A 299 246 39 0 0 26 [[593, 1077]] 1.0 4m7i Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1e-49 175.3 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 8EQEAAA Q9NZJ5 585 1080 1116.0 WQ2:1101 Type1.5_Back Inactive DFGin 6.201 13.869 None DFGAsp-rot-in -81.55, -152.92 -57.14, 146.2 197.5, 2.52 -169.63, 166.16 75.82, 96.97 68.96, 171.99 out-out out 13.231 Saltbr-out 9.153 HRD-in -75.93, -57.84 73.17, 14.99 out-out-out SNCooo out-out ActLoopNT-out 12.818 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.43 APE8-rot-out 173.87 APE67-dihe-in -71.31, -21.9 -114.54, 9.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.559 0.227 0.287 AAA 317 256 35 0 0 26 [[593, 1077]] 1.0 8eqe Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7JA Q9NZJ5 585 1086 1116.0 3Z1:1101 Type1 Inactive DFGout 12.646 11.746 BBAminus DFGAsp-rot-in -176.98, -166.74 -114.82, 83.88 172.95, 30.26 -76.24, -41.23 290.33, 81.74 65.53, 38.29 out-out out 11.617 Saltbr-out 8.252 HRD-in -69.35, -52.51 78.62, -22.7 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.01, -22.0 999.0, 154.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.3 0.196 0.225 A 317 257 40 0 0 28 [[593, 1077]] 1.0 4x7j Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7KA Q9NZJ5 585 1087 1116.0 3Z3:1101 Type2 Inactive DFGout 12.544 11.365 BBAminus DFGAsp-rot-in -164.33, -167.96 -113.88, 89.92 182.35, -2.4 -77.28, -42.74 283.96, 78.23 66.26, 40.59 out-out out 11.511 Saltbr-out 9.706 HRD-in -84.11, -56.75 85.81, -21.5 out-out-out SNCooo out-out ActLoopNT-out 21.153 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.05 APE8-rot-out 179.62 APE67-dihe-in -59.37, -28.86 -109.52, 8.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.8 0.177 0.196 A 317 260 38 0 0 26 [[593, 1077]] 1.0 4x7k Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7LA Q9NZJ5 585 1087 1116.0 3Z4:1101 Type2 Inactive DFGout 12.642 11.31 BBAminus DFGAsp-rot-in -164.8, -167.28 -114.04, 88.17 182.01, -4.16 -74.87, -43.18 282.08, 78.75 64.58, 42.25 out-out out 11.456 Saltbr-out 9.844 HRD-in -84.66, -55.97 85.16, -23.49 out-out-out SNCooo out-out ActLoopNT-out 20.918 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.96 APE8-rot-out 184.8 APE67-dihe-in -58.09, -32.47 -109.67, 8.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 1.9 0.172 0.193 A 317 260 38 0 0 26 [[593, 1077]] 1.0 4x7l Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7NA Q9NZJ5 585 1087 1116.0 3Z5:1101 Type2 Inactive DFGout 12.624 11.336 BBAminus DFGAsp-rot-in -159.96, -166.6 -113.91, 86.84 181.7, -15.18 -73.68, -38.78 284.48, 77.45 62.04, 46.12 out-out out 11.466 Saltbr-out 9.77 HRD-in -89.68, -53.93 84.75, -24.71 out-out-out SNCooo out-out ActLoopNT-out 21.103 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.8 APE8-rot-out 184.51 APE67-dihe-in -64.57, -30.33 -109.92, 11.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.35 0.211 0.245 A 317 259 39 0 0 26 [[593, 1077]] 1.0 4x7n Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK3 E2AK3_HUMAN 4X7HA Q9NZJ5 585 1086 1116.0 3Z2:1101 Type2 Inactive DFGout 16.988 7.988 None DFGAsp-rot-in -147.44, -164.97 -147.31, 104.14 185.0, 27.01 -56.25, -41.74 188.75, 74.74 -79.36, 999.0 out-out out 11.692 Saltbr-out 7.361 HRD-in -84.56, -56.41 85.91, -24.54 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.13 APE8-rot-in 311.97 APE67-dihe-in -61.01, -23.09 -108.5, -0.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D937N None None XRAY 2.0 0.202 0.214 A 317 256 41 0 0 29 [[593, 1077]] 1.0 4x7h Homo sapiens OTHER_EIF2AK3_HUMAN OTHER 1.3e-48 171.7 2 254 253 954 955 956 958 960 622 639 643 934 936 935 937 1006 994 989 988 987 986 985 984 983 889 Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K2A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.617 14.333 BLAminus DFGAsp-rot-in -136.29, -175.54 55.03, 79.43 198.56, 25.07 -90.03, 22.0 290.92, 79.21 -58.96, -26.48 in-in in 9.506 Saltbr-in 2.949 HRD-in -71.79, -47.78 64.97, -9.83 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.06, 154.72 APE9-dihe-na 104.42, 174.21 APE8-dihe-in -78.42, 122.57 APE8-rot-in 303.04 APE67-dihe-in -70.42, -29.98 -45.44, -33.85 APE12-dist-in 11.12 APE11-dist-in 11.892 APE10-dist-in 5.918 APE9-dist-in 3.736 None None None AF2 -1.0 1.0 1.0 A 428 428 0 0 0 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K2 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN AF-Q9P2K8-K4A Q9P2K8 582 1009 1649.0 No_ligand No_ligand Active DFGin 6.606 13.998 BLAminus DFGAsp-rot-in -136.5, -169.45 54.98, 63.3 208.76, -0.23 -76.1, 15.72 292.56, 86.18 -62.07, -22.72 in-in in 8.808 Saltbr-in 2.746 HRD-in -75.42, -42.82 64.6, -12.86 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.36, 139.51 APE9-dihe-na 113.38, 169.46 APE8-dihe-in -72.14, 130.61 APE8-rot-in 295.69 APE67-dihe-in -77.95, -5.75 -49.91, -35.42 APE12-dist-in 11.068 APE11-dist-in 11.931 APE10-dist-in 6.15 APE9-dist-in 3.359 None None None AF2 -1.0 1.0 1.0 A 428 428 0 0 0 0 [[277, 541], [590, 1001]] 2.0 AF-Q9P2K8-K4 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 1.4e-46 165.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3NA Q9P2K8 584 1003 1649.0 KA4:62500 Type1 Inactive DFGin 6.942 14.896 BLAminus DFGAsp-rot-out -161.77, -164.95 51.61, 53.4 268.54, -60.79 -59.48, -46.57 276.83, 65.68 113.21, 101.52 out-out out 11.833 Saltbr-out 11.498 HRD-in -82.81, -56.02 77.87, -40.32 out-out-none SNCoon out-none ActLoopNT-out 8.528 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 6.58 APE8-rot-na 302.93 APE67-dihe-in -70.39, -29.28 -70.81, -30.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 3.01 0.219 0.277 A 317 242 55 0 0 27 [[277, 541], [590, 1001]] 2.0 6n3n Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.5e-45 161.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3OA Q9P2K8 584 1004 1649.0 KA7:62500 Type1.5_Back Inactive DFGin 6.652 15.208 BLAminus DFGAsp-rot-out -153.67, -168.18 56.94, 54.84 276.99, -31.06 -57.06, -41.03 283.3, 70.25 96.81, 112.56 out-out out 12.227 Saltbr-out 12.581 HRD-in -73.69, -58.26 76.04, -15.13 out-out-none SNCoon out-none ActLoopNT-out 8.658 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.04 APE8-rot-na 294.34 APE67-dihe-in -83.15, -13.22 -77.59, -5.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899E,T904E None None XRAY 2.4 0.202 0.254 A 317 252 46 0 0 26 [[277, 541], [590, 1001]] 2.0 6n3o Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.5e-45 161.1 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6A Q9P2K8 584 1004 1649.0 38O:1701 Type1 Inactive DFGin 4.545 13.832 None DFGAsp-rot-out -64.42, 179.79 -78.36, -177.52 69.56, -51.49 -104.81, 135.74 11.85, 74.61 -87.56, 999.0 out-out out 10.404 Saltbr-out 7.228 HRD-in -78.55, -45.81 67.95, -11.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -139.37, 156.89 APE9-dihe-na 68.88, -136.49 APE8-dihe-out -63.0, -22.3 APE8-rot-out 54.98 APE67-dihe-in -64.33, -22.31 -64.88, -30.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.309 D848N None None XRAY 2.8 0.213 0.258 A 320 269 26 0 0 20 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6B Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.743 14.437 None DFGAsp-rot-out -62.22, 177.25 -71.17, -177.31 71.08, -57.72 -113.77, 112.84 16.57, 83.07 -117.04, 75.83 out-out out 10.63 Saltbr-out 6.773 HRD-in -73.84, -58.14 68.49, 11.03 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -145.51, 135.89 APE9-dihe-na 67.14, -114.96 APE8-dihe-out -68.69, -35.73 APE8-rot-out 40.19 APE67-dihe-in -61.7, -18.1 -60.4, -26.4 APE12-dist-out 22.808 APE11-dist-out 18.791 APE10-dist-out 18.981 APE9-dist-out 12.646 D848N None None XRAY 2.8 0.213 0.258 B 320 275 22 0 0 18 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6C Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 5.153 15.331 None DFGAsp-rot-out -67.88, 178.26 -74.84, 168.69 62.03, -44.97 -62.36, -56.97 309.72, 121.46 57.54, 31.05 out-out out 10.431 Saltbr-out 6.787 HRD-in -71.08, -48.65 67.11, -5.82 out-out-out SNCooo out-out ActLoopNT-out 7.73 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.35 APE8-dihe-out -115.25, -20.91 APE8-rot-out 51.72 APE67-dihe-in -84.71, -19.81 -111.62, 33.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.792 D848N None None XRAY 2.8 0.213 0.258 C 320 267 30 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QQ6D Q9P2K8 584 1006 1649.0 38O:1701 Type1 Inactive DFGin 4.793 14.782 None DFGAsp-rot-out -71.0, 172.41 -73.73, 163.04 64.81, -29.71 -66.19, -82.98 327.33, 91.13 74.54, 67.6 out-out out 11.102 Saltbr-out 6.778 HRD-in -68.97, -46.58 79.03, -46.68 out-out-none SNCoon out-none ActLoopNT-out 6.505 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.25, -17.58 999.0, -55.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.8 0.213 0.258 D 320 260 37 0 0 29 [[277, 541], [590, 1001]] 2.0 7qq6 Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.037 8.181 None DFGAsp-rot-out -60.18, 141.19 -134.64, 94.13 42.41, 13.86 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.114 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.748 APE10-dist-out 24.316 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318 254 42 0 0 24 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKA Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.824 9.513 None DFGAsp-rot-none -134.51, -151.1 -121.46, -46.25 999.0, 999.0 35.17, 27.68 228.21, 155.53 -84.53, 128.11 out-none out 11.558 Saltbr-none 999.0 HRD-in -76.45, -48.97 72.32, -6.8 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.65 APE8-dihe-out -87.38, 8.98 APE8-rot-none 999.0 APE67-dihe-in -67.63, -12.84 -66.2, 0.93 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.282 D848N None None XRAY 2.3 0.214 0.243 A 318 245 48 0 0 33 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKB Q9P2K8 583 998 1649.0 G41:1701 Type1 Inactive DFGout 17.844 9.39 None DFGAsp-rot-in -144.52, -139.04 -156.42, 125.77 162.38, 78.01 -114.71, 16.01 223.02, 149.14 -71.92, 114.82 out-out out 11.848 Saltbr-out 8.195 HRD-in -79.04, -54.75 67.92, 8.38 out-out-out SNCooo out-out ActLoopNT-out 14.534 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -41.73 APE8-dihe-out -76.87, -29.31 APE8-rot-none 999.0 APE67-dihe-in -63.87, -23.61 -70.02, -18.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.868 D848N None None XRAY 2.3 0.214 0.243 B 318 249 44 0 0 26 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKC Q9P2K8 583 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.942 9.721 None DFGAsp-rot-in -140.22, -142.02 -158.37, 117.76 168.26, 58.25 -96.27, -4.59 219.72, 151.65 -71.27, 106.76 out-out out 11.963 Saltbr-out 7.857 HRD-in -88.1, -52.43 58.54, 27.47 out-out-none SNCoon out-none ActLoopNT-out 15.315 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -59.9 APE8-rot-none 999.0 APE67-dihe-in -67.01, -4.12 -84.11, -11.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 C 318 249 47 0 0 30 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKD Q9P2K8 583 1003 1649.0 G41:1701 Type1 Inactive DFGout 17.703 9.322 None DFGAsp-rot-in -139.27, -135.78 -159.12, 124.73 166.01, 54.36 -118.38, 23.17 221.49, 144.06 -75.45, 126.8 out-out out 11.834 Saltbr-out 8.431 HRD-in -88.04, -58.27 56.71, 45.95 out-out-out SNCooo out-out ActLoopNT-out 14.749 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.87 APE8-dihe-out -67.23, -22.9 APE8-rot-none 999.0 APE67-dihe-in -74.1, -19.72 -68.07, -8.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.557 D848N None None XRAY 2.3 0.214 0.243 D 318 254 41 0 0 27 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKE Q9P2K8 584 1004 1649.0 G41:1701 Type1 Inactive DFGout 17.779 9.822 None DFGAsp-rot-in -151.76, -141.6 -160.26, 136.01 209.3, -77.46 -98.22, 91.17 239.64, 115.15 -107.96, 84.44 out-none out 11.082 Saltbr-none 999.0 HRD-in -88.02, -51.01 74.43, -13.48 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 E 318 241 54 0 0 42 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKG Q9P2K8 584 1007 1649.0 G41:1701 Type1 Inactive DFGout 18.192 10.134 None DFGAsp-rot-in -152.52, -143.94 -140.15, -46.73 208.16, -84.46 82.87, -54.7 218.3, 133.54 -74.32, 999.0 out-out out 11.658 Saltbr-out 9.2 HRD-in -81.42, -58.02 87.03, -25.33 out-out-none SNCoon out-none ActLoopNT-out 6.618 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -52.87 APE8-rot-none 999.0 APE67-dihe-in -65.85, -22.5 -65.49, -20.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D848N None None XRAY 2.3 0.214 0.243 G 318 257 41 0 0 26 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LA Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.724 8.694 None DFGAsp-rot-in -131.92, -171.74 -165.1, 131.81 183.34, 17.34 -91.39, 999.0 282.47, 16.23 999.0, 999.0 in-in in 8.375 Saltbr-in 3.222 HRD-in -61.96, -55.14 81.8, -15.53 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.98 APE8-rot-none 999.0 APE67-dihe-in -81.86, -12.43 -63.68, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 A 330 230 65 0 0 36 [[277, 541], [590, 1001]] 2.0 6n3l Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 3.9e-45 160.5 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LB Q9P2K8 584 1002 1649.0 KAV:62501 Type2 Inactive DFGout 15.445 8.619 None DFGAsp-rot-in -134.73, -168.42 -167.35, 133.28 182.98, 14.8 -92.51, 999.0 285.34, 13.72 999.0, 999.0 in-in in 8.388 Saltbr-in 3.482 HRD-in -61.97, -53.58 83.5, -20.28 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.86 APE8-rot-none 999.0 APE67-dihe-in -82.56, -10.84 -61.36, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K807A,D848N,T899A,T904A None None XRAY 2.61 0.226 0.29 B 330 227 68 0 0 36 [[277, 541], [590, 1001]] 2.0 6n3l Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 3.9e-45 160.5 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4Z7HB O75460 562 962 977.0 4L5:1001 Type1 Inactive DFGin 5.135 14.518 ABAminus DFGAsp-rot-in -147.31, -25.96 -101.01, 93.63 209.01, -20.67 -84.21, 0.58 280.19, 77.98 -61.73, -35.98 in-in in 8.295 Saltbr-in 2.88 HRD-in -73.65, -45.51 64.99, 2.13 in-in-out SNCiio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -82.39, -0.49 APE9-dihe-na 151.41, -152.92 APE8-dihe-in -124.62, 124.86 APE8-rot-out 45.76 APE67-dihe-inflip 103.66, -22.96 -54.37, 143.35 APE12-dist-none 999.0 APE11-dist-in 8.436 APE10-dist-out 8.736 APE9-dist-in 4.695 None None None XRAY 2.9 0.202 0.225 B 416 388 13 0 0 7 [[571, 832]] 1.0 4z7h Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN AF-O75460-K1A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.226 14.358 BLAminus DFGAsp-rot-in -136.1, 174.69 62.75, 82.9 195.21, 16.75 -90.11, 8.09 278.92, 58.01 -56.59, -35.42 in-in in 8.623 Saltbr-in 2.739 HRD-in -70.55, -49.28 65.1, -0.16 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.61, 153.38 APE9-dihe-na 118.83, 174.73 APE8-dihe-in -98.29, 131.32 APE8-rot-in 303.59 APE67-dihe-inflip 83.09, -9.62 -47.44, 134.97 APE12-dist-in 10.873 APE11-dist-in 11.147 APE10-dist-in 5.238 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[571, 832]] 1.0 AF-O75460-K1 Homo sapiens OTHER_ERN1_HUMAN CAMK 8.5e-36 129.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN AF-O75460-K3A O75460 561 840 977.0 No_ligand No_ligand Active DFGin 5.249 14.149 BLAminus DFGAsp-rot-in -135.31, -174.96 58.8, 76.05 198.78, 24.44 -86.75, 1.33 278.92, 66.56 -57.5, -35.04 in-in in 8.461 Saltbr-in 2.679 HRD-in -73.71, -47.28 67.17, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -67.31, 152.38 APE9-dihe-na 117.01, 175.14 APE8-dihe-in -93.16, 133.21 APE8-rot-in 303.49 APE67-dihe-inflip 79.17, -0.04 -48.5, 133.79 APE12-dist-in 10.894 APE11-dist-in 11.197 APE10-dist-in 5.303 APE9-dist-in 3.42 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[571, 832]] 1.0 AF-O75460-K3 Homo sapiens OTHER_ERN1_HUMAN CAMK 8.5e-36 129.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 5HGIA O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.609 14.643 BLAminus DFGAsp-rot-out -145.05, -173.6 59.23, 77.97 288.76, -15.04 -93.33, 15.89 299.4, 90.09 -56.25, -41.67 in-in in 8.835 Saltbr-in 3.085 HRD-in -70.44, -52.16 82.22, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.82, 158.67 APE9-dihe-na -55.87, 177.33 APE8-dihe-in -86.18, 152.71 APE8-rot-in 291.18 APE67-dihe-inflip 109.66, -27.51 -52.0, 151.26 APE12-dist-in 7.716 APE11-dist-out 6.849 APE10-dist-out 9.218 APE9-dist-in 4.362 None None None XRAY 2.584 0.214 0.247 A 431 395 5 0 0 0 [[571, 832]] 1.0 5hgi Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDFB O75460 562 964 977.0 No_ligand No_ligand Inactive DFGin 5.734 14.864 BLAminus DFGAsp-rot-out -147.47, -177.07 57.93, 76.76 284.41, 4.45 -96.5, 15.93 283.55, 47.82 -59.81, -43.08 in-in in 8.228 Saltbr-in 2.737 HRD-in -73.76, -49.3 76.45, -0.87 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, -169.01 APE9-dihe-na 101.44, -83.65 APE8-dihe-in -134.49, 143.31 APE8-rot-in 313.33 APE67-dihe-inflip 129.9, -41.41 -81.7, 159.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.524 APE9-dist-out 7.438 None None None XRAY 2.54 0.209 0.263 B 431 400 3 0 0 2 [[571, 832]] 1.0 6xdf Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3BA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 5.281 15.014 BLAminus DFGAsp-rot-in -143.27, -170.93 56.51, 82.48 187.17, 81.6 -97.69, 18.76 283.82, 27.48 -70.15, -29.01 in-in in 9.017 Saltbr-in 3.226 HRD-in -67.85, -45.67 72.89, 0.99 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -72.27, -21.84 APE9-dihe-na 147.89, -147.39 APE8-dihe-in -108.47, 126.95 APE8-rot-in 297.0 APE67-dihe-inflip 99.73, -10.05 -56.76, 133.68 APE12-dist-in 7.506 APE11-dist-out 7.577 APE10-dist-out 10.04 APE9-dist-in 4.019 None None None XRAY 2.57 0.206 0.246 A 434 398 0 0 0 0 [[571, 832]] 1.0 6w3b Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CA O75460 560 964 977.0 No_ligand No_ligand Active DFGin 6.106 14.236 BLAminus DFGAsp-rot-in -143.3, -169.77 61.92, 75.26 196.73, 30.79 -99.59, 5.17 293.74, 80.96 -57.56, -26.8 in-in in 8.19 Saltbr-in 2.438 HRD-in -73.83, -48.09 71.71, -9.73 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.3, -33.45 APE9-dihe-na -62.43, 169.01 APE8-dihe-in -93.38, 133.53 APE8-rot-in 300.11 APE67-dihe-inflip 106.95, -8.39 -49.76, 124.1 APE12-dist-in 11.245 APE11-dist-in 11.396 APE10-dist-in 5.43 APE9-dist-in 3.449 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 A 434 405 0 0 0 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CB O75460 560 963 977.0 No_ligand No_ligand Active DFGin 6.106 14.899 BLAminus DFGAsp-rot-in -154.48, -168.03 55.85, 78.98 191.84, 22.41 -100.05, 13.54 285.56, 16.26 -60.83, -29.52 in-in in 8.366 Saltbr-in 2.634 HRD-in -75.16, -45.21 69.8, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.23, 157.93 APE9-dihe-na 117.83, 146.57 APE8-dihe-in -81.19, 135.69 APE8-rot-in 308.77 APE67-dihe-inflip 111.32, -6.95 -54.24, 124.62 APE12-dist-in 10.887 APE11-dist-in 10.897 APE10-dist-in 4.957 APE9-dist-in 3.541 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 B 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CC O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.657 15.019 BLAminus DFGAsp-rot-in -147.84, -172.12 60.8, 76.5 191.75, 20.71 -95.31, 10.61 280.4, 53.86 -59.0, -26.79 in-in in 8.706 Saltbr-in 2.721 HRD-in -80.88, -50.26 69.52, 4.83 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.43, 153.53 APE9-dihe-na 125.25, 174.09 APE8-dihe-in -105.72, 131.11 APE8-rot-in 300.67 APE67-dihe-inflip 110.66, -4.8 -51.94, 122.81 APE12-dist-in 11.239 APE11-dist-in 11.12 APE10-dist-in 5.218 APE9-dist-in 3.675 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 C 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3CD O75460 560 963 977.0 No_ligand No_ligand Active DFGin 5.932 15.058 BLAminus DFGAsp-rot-in -157.54, -163.82 60.31, 71.97 215.83, 27.37 -98.14, 3.34 281.98, 17.28 -56.04, -29.73 in-in in 8.642 Saltbr-in 2.715 HRD-in -75.91, -46.58 71.49, -6.58 in-in-in SNCiii in-in ActLoopNT-in 2.71 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.66, -18.6 APE9-dihe-na -64.06, 167.42 APE8-dihe-in -92.49, 134.25 APE8-rot-in 304.43 APE67-dihe-inflip 103.66, -4.02 -51.74, 125.98 APE12-dist-in 11.302 APE11-dist-in 11.218 APE10-dist-in 5.258 APE9-dist-in 3.482 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.3 0.208 0.248 D 434 404 0 0 0 0 [[571, 832]] 1.0 6w3c Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus DFGAsp-rot-in -149.66, -173.45 57.49, 66.53 201.33, -9.38 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus DFGAsp-rot-in -140.88, -173.22 59.3, 72.64 207.2, -16.91 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWA O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.753 15.848 BLAminus DFGAsp-rot-in -137.11, -164.14 55.29, 61.49 216.41, -10.57 -82.92, 7.86 279.34, 27.53 -61.24, -35.15 in-in in 9.281 Saltbr-in 3.217 HRD-in -66.48, -56.29 77.33, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -75.9, 139.91 APE9-dihe-na 137.0, 174.42 APE8-dihe-in -105.74, 137.36 APE8-rot-in 313.93 APE67-dihe-inflip 116.47, -18.45 -55.17, 118.89 APE12-dist-in 10.655 APE11-dist-in 11.273 APE10-dist-in 5.237 APE9-dist-in 3.631 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 A 434 403 0 0 0 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWB O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.659 15.595 BLAminus DFGAsp-rot-in -145.27, -164.83 46.92, 70.18 188.19, 78.23 -87.21, 11.29 280.69, 69.55 -62.43, -36.43 in-in in 9.514 Saltbr-in 2.916 HRD-in -81.2, -46.9 74.25, -11.86 in-in-out SNCiio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -59.45, 144.76 APE9-dihe-na 126.14, -167.15 APE8-dihe-in -135.75, 140.85 APE8-rot-out 210.8 APE67-dihe-inflip 99.64, -22.14 -57.98, 140.11 APE12-dist-in 10.802 APE11-dist-in 11.2 APE10-dist-in 5.274 APE9-dist-in 3.54 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 B 434 403 0 0 0 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWC O75460 562 964 977.0 A1IOO:1001 Type1 Active DFGin 5.635 15.559 BLAminus DFGAsp-rot-in -132.52, 179.7 73.16, 53.18 215.43, 48.35 -77.31, 13.24 285.48, 55.31 -73.1, -19.29 in-in in 9.039 Saltbr-in 3.019 HRD-in -82.58, -51.91 71.45, 18.84 in-in-in SNCiii in-in ActLoopNT-in 2.63 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.81, 130.02 APE9-dihe-na 148.27, 178.17 APE8-dihe-in -119.07, 134.7 APE8-rot-in 323.09 APE67-dihe-inflip 99.28, -15.5 -52.59, 133.44 APE12-dist-in 10.773 APE11-dist-in 11.223 APE10-dist-in 5.348 APE9-dist-in 3.665 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 C 434 403 0 0 0 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9GOWD O75460 562 964 977.0 A1IOO:1001 Type1 Inactive DFGin 5.877 15.941 BLAminus DFGAsp-rot-in -144.08, -162.9 48.88, 78.62 175.05, -52.73 -99.04, 18.45 261.61, 69.28 -69.53, -42.63 in-out in 9.474 Saltbr-out 3.697 HRD-in -82.34, -51.42 71.84, 19.12 out-in-out SNCoio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -60.38, 141.0 APE9-dihe-na 147.72, -174.34 APE8-dihe-in -119.1, 140.61 APE8-rot-out 31.47 APE67-dihe-inflip 82.22, -18.82 -56.96, 151.1 APE12-dist-in 10.965 APE11-dist-in 11.521 APE10-dist-in 5.448 APE9-dist-in 3.936 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 3.0 0.234 0.281 D 434 303 2 0 0 0 [[571, 832]] 1.0 9gow Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.486 BLAminus DFGAsp-rot-in -136.61, -178.37 67.07, 78.89 204.21, -11.93 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.204 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.729 APE9-dist-in 3.977 None None None XRAY 2.08 0.192 0.217 A 434 398 4 0 0 4 [[571, 832]] 1.0 6w3k Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3EB O75460 563 963 977.0 SJV:1001 Type1.5_Back Inactive DFGin 5.795 15.517 BLAminus DFGAsp-rot-in -141.88, 176.99 63.2, 84.04 191.54, 20.4 -105.56, 28.54 300.08, 169.13 -67.07, -42.47 out-out out 10.107 Saltbr-out 5.707 HRD-out -80.93, 139.0 -122.23, -35.4 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -5.99 APE9-dihe-na -74.91, 153.53 APE8-dihe-out 63.33, 175.78 APE8-rot-out 67.1 APE67-dihe-inflip 108.9, -22.83 -150.99, 138.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.146 APE9-dist-out 6.983 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 B 431 389 12 0 0 4 [[571, 832]] 1.0 6w3e Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDFA O75460 560 966 977.0 N94:1002 Type1.5_Back Inactive DFGin 6.383 15.199 BLAminus DFGAsp-rot-in -130.29, -176.4 60.9, 76.83 197.37, -0.9 -90.68, 29.29 294.67, 76.62 -70.73, -33.39 out-out out 10.156 Saltbr-out 5.093 HRD-in -82.04, -48.49 78.58, -9.6 out-in-out SNCoio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -73.17, -32.0 APE9-dihe-na 161.12, -145.76 APE8-dihe-in -111.23, 117.63 APE8-rot-in 300.24 APE67-dihe-inflip 110.41, -26.97 -49.33, 126.92 APE12-dist-in 7.63 APE11-dist-out 6.918 APE10-dist-out 9.798 APE9-dist-in 3.86 None None None XRAY 2.54 0.209 0.263 A 431 402 5 0 0 0 [[571, 832]] 1.0 6xdf Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 7BMKA O75460 561 966 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.305 15.604 BLAminus DFGAsp-rot-in -134.78, 175.72 71.56, 88.08 201.19, -25.98 -95.42, 16.11 280.14, 64.53 -63.54, -33.93 out-out out 10.62 Saltbr-out 5.429 HRD-in -79.03, -50.32 75.82, -1.9 out-in-out SNCoio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -71.86, -22.99 APE9-dihe-na 146.38, -151.63 APE8-dihe-in -103.7, 128.54 APE8-rot-in 300.23 APE67-dihe-inflip 91.08, -11.6 -49.87, 131.36 APE12-dist-in 7.482 APE11-dist-out 7.01 APE10-dist-out 9.895 APE9-dist-in 3.716 None None None XRAY 1.85 0.192 0.235 A 434 406 0 0 0 0 [[571, 832]] 1.0 7bmk Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 7BMKB O75460 562 963 977.0 U4N:1001 Type1.5_Back Inactive DFGin 5.47 15.557 BLAminus DFGAsp-rot-in -136.75, 176.32 69.57, 85.31 201.68, -26.76 -94.6, 15.21 280.65, 62.8 -61.14, -35.65 out-out out 10.425 Saltbr-out 5.295 HRD-in -76.97, -51.76 73.84, 1.59 out-in-out SNCoio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioio APE10-dihe-na -80.44, 159.09 APE9-dihe-na -62.97, -36.0 APE8-dihe-in -102.05, 125.52 APE8-rot-in 305.35 APE67-dihe-inflip 117.81, -24.89 -71.98, 170.65 APE12-dist-in 10.017 APE11-dist-out 6.417 APE10-dist-in 7.066 APE9-dist-out 8.735 None None None XRAY 1.85 0.192 0.235 B 434 392 10 0 0 0 [[571, 832]] 1.0 7bmk Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6URCA O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.171 14.431 BLAminus DFGAsp-rot-in -137.78, -167.93 65.57, 72.79 216.46, -14.78 -93.53, 16.27 296.4, 97.38 -65.24, -15.16 out-out out 10.078 Saltbr-out 5.427 HRD-in -79.31, -54.62 74.23, 3.96 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.3, -9.99 APE9-dihe-na 149.54, -144.19 APE8-dihe-in -113.92, 127.41 APE8-rot-in 303.4 APE67-dihe-inflip 100.0, -7.56 -46.92, 125.76 APE12-dist-in 10.921 APE11-dist-out 7.261 APE10-dist-out 9.666 APE9-dist-in 3.801 None None None XRAY 2.2 0.223 0.274 A 434 400 0 0 0 0 [[571, 832]] 1.0 6urc Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6URCB O75460 560 963 977.0 QFV:1001 Type1.5_Back Inactive DFGin 7.051 14.225 BLAminus DFGAsp-rot-in -133.22, -173.47 69.03, 75.97 207.3, -25.89 -95.56, 16.52 300.55, 96.62 -60.7, -19.84 out-out out 10.062 Saltbr-out 5.58 HRD-in -76.52, -51.32 73.26, 7.62 out-in-out SNCoio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -86.29, -17.31 APE9-dihe-na 144.52, -148.41 APE8-dihe-in -105.98, 124.4 APE8-rot-in 298.12 APE67-dihe-inflip 103.6, -12.44 -49.39, 126.46 APE12-dist-in 10.817 APE11-dist-out 7.084 APE10-dist-out 9.909 APE9-dist-in 3.837 None None None XRAY 2.2 0.223 0.274 B 434 398 0 0 0 0 [[571, 832]] 1.0 6urc Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDB O75460 560 963 977.0 N97:1001 Type1.5_Back Inactive DFGin 7.109 14.526 BLAminus DFGAsp-rot-in -139.89, -179.2 70.17, 73.7 194.07, 16.37 -98.79, 17.74 298.51, 86.41 -64.67, -28.57 in-out in 9.962 Saltbr-out 5.494 HRD-in -74.08, -50.98 72.16, 2.0 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -71.87, 142.87 APE9-dihe-na 140.33, 179.07 APE8-dihe-in -119.71, 134.07 APE8-rot-in 305.81 APE67-dihe-inflip 102.26, -11.35 -53.88, 126.31 APE12-dist-in 10.974 APE11-dist-in 10.707 APE10-dist-in 4.783 APE9-dist-in 3.481 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 B 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4U6RA O75460 561 963 977.0 3E4:1001 Type1.5_Back Inactive DFGin 7.047 14.409 BLAminus DFGAsp-rot-in -137.98, -174.58 66.91, 71.23 213.38, 2.11 -95.79, 12.94 302.54, 101.22 -59.26, -23.05 out-out out 10.674 Saltbr-out 5.974 HRD-in -69.95, -43.6 74.35, -6.96 out-in-out SNCoio in-out ActLoopNT-in 2.993 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.62, 70.84 APE9-dihe-na 123.49, -154.22 APE8-dihe-in -117.41, 132.07 APE8-rot-in 301.36 APE67-dihe-inflip 102.11, -11.56 -49.68, 126.85 APE12-dist-in 11.011 APE11-dist-in 10.273 APE10-dist-out 8.43 APE9-dist-in 3.436 None None None XRAY 2.5 0.204 0.246 A 455 403 0 0 0 0 [[571, 832]] 1.0 4u6r Homo sapiens OTHER_ERN1_HUMAN CAMK 4e-35 127.7 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDBA O75460 561 964 977.0 N8S:1001 Type1.5_Back Inactive DFGin 7.133 14.329 BLAminus DFGAsp-rot-in -132.32, -176.36 63.12, 79.47 189.86, -4.5 -100.65, 32.62 307.21, 90.79 -67.25, -28.96 out-out out 10.475 Saltbr-out 4.795 HRD-in -83.13, -48.83 76.19, 2.79 out-in-out SNCoio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -66.73, -30.45 APE9-dihe-na 149.19, -146.33 APE8-dihe-in -109.5, 126.62 APE8-rot-in 302.1 APE67-dihe-inflip 92.9, -11.46 -58.42, 139.25 APE12-dist-in 7.086 APE11-dist-out 6.84 APE10-dist-out 9.792 APE9-dist-in 3.979 None None None XRAY 2.45 0.195 0.227 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdb Homo sapiens OTHER_ERN1_HUMAN CAMK 3.2e-34 124.7 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.559 15.899 BLAminus DFGAsp-rot-out -140.85, 172.03 60.0, 89.13 289.15, -33.3 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.584 Saltbr-out 7.056 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431 366 31 0 0 21 [[571, 832]] 1.0 6w3e Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.489 15.205 BLAminus DFGAsp-rot-out -139.2, -157.42 53.89, 65.22 274.02, 87.33 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.188 Saltbr-out 12.042 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.114 APE10-dist-in 7.347 APE9-dist-out 9.016 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.499 14.81 BLAminus DFGAsp-rot-in -137.56, -175.69 71.07, 82.79 202.33, -9.91 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.069 Saltbr-out 11.269 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.721 APE11-dist-out 7.141 APE10-dist-out 10.097 APE9-dist-in 3.899 None None None XRAY 2.43 0.184 0.251 A 448 403 0 0 0 0 [[571, 832]] 1.0 8uvl Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-34 124.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.106 13.454 BLBplus DFGAsp-rot-out -141.52, 169.79 75.76, 4.13 294.43, 24.59 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.885 Saltbr-out 13.41 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.406 APE10-dist-out 8.161 APE9-dist-in 3.423 None None None XRAY 3.102 0.234 0.273 A 405 383 18 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.204 13.179 BLBplus DFGAsp-rot-out -141.12, 169.65 69.57, 15.58 293.67, 24.1 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.88 Saltbr-out 13.118 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.672 APE10-dist-in 7.568 APE9-dist-in 3.528 None None None XRAY 3.102 0.234 0.273 B 405 385 15 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.292 13.556 BLBplus DFGAsp-rot-out -142.06, 170.34 76.33, 5.28 296.09, 25.39 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.194 Saltbr-out 13.253 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.41 APE10-dist-in 7.784 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405 379 21 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.34 13.709 BLBplus DFGAsp-rot-out -135.51, 176.11 64.76, 22.4 294.34, -2.15 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.088 Saltbr-out 13.069 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.558 APE10-dist-out 9.123 APE9-dist-in 3.196 None None None XRAY 2.7 0.238 0.294 A 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.483 13.646 BLBplus DFGAsp-rot-out -139.9, 176.5 76.83, 14.87 282.35, -2.41 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.936 Saltbr-out 12.658 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.701 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.213 APE9-dist-in 3.477 None None None XRAY 2.7 0.238 0.294 B 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.544 13.173 BLBplus DFGAsp-rot-out -149.53, -176.42 65.18, 18.98 297.03, -0.74 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.142 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.838 APE11-dist-in 13.243 APE10-dist-out 9.353 APE9-dist-in 3.507 None None None XRAY 2.7 0.238 0.294 C 432 390 14 0 0 11 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.409 13.263 BLBplus DFGAsp-rot-out -138.88, 177.03 72.28, 10.83 287.64, -11.27 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.018 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.113 APE9-dist-in 4.038 None None None XRAY 2.7 0.238 0.294 D 432 387 16 0 0 14 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9N88A O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.495 14.396 BLBplus DFGAsp-rot-out -125.12, 173.56 61.62, 32.01 306.9, -52.71 -93.6, 167.16 52.37, 88.56 65.58, 27.08 in-in in 8.405 Saltbr-in 2.935 HRD-in -63.01, -46.54 69.36, -1.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.47 APE9-dihe-na 82.39, -50.55 APE8-dihe-in -47.73, 127.95 APE8-rot-in 291.31 APE67-dihe-inflip 89.37, 13.1 -79.77, 123.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.432 APE9-dist-out 7.977 None None None EM 2.6 999.0 999.0 A 402 379 23 0 0 16 [[571, 832]] 1.0 9n88 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 9N88E O75460 563 964 977.0 No_ligand No_ligand Inactive DFGin 4.496 14.396 BLBplus DFGAsp-rot-out -125.13, 173.55 61.65, 32.03 306.85, -52.71 -93.6, 167.11 52.36, 88.6 65.62, 27.08 in-in in 8.405 Saltbr-in 2.936 HRD-in -63.0, -46.58 69.41, -1.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 159.45 APE9-dihe-na 82.42, -50.53 APE8-dihe-in -47.73, 127.97 APE8-rot-in 291.31 APE67-dihe-inflip 89.32, 13.1 -79.8, 123.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.433 APE9-dist-out 7.977 None None None EM 2.6 999.0 999.0 E 402 379 23 0 0 16 [[571, 832]] 1.0 9n88 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W39A O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.589 14.569 BLBplus DFGAsp-rot-in -139.66, 174.98 64.22, 28.56 227.24, 9.69 -90.96, 160.06 48.25, 86.99 74.2, -3.07 in-in in 8.854 Saltbr-in 2.868 HRD-in -66.64, -55.32 82.3, -19.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 195.33 APE67-dihe-out 108.3, -8.16 -110.65, -131.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 A 431 374 24 0 0 19 [[571, 832]] 1.0 6w39 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W39B O75460 563 963 977.0 SJG:1001 Type1 Inactive DFGin 4.61 14.538 BLBplus DFGAsp-rot-in -144.1, 177.6 64.91, 27.62 224.26, 9.89 -88.82, 154.64 46.85, 89.19 64.91, 16.36 in-in in 8.582 Saltbr-in 3.517 HRD-in -72.2, -52.15 80.89, -14.52 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.25 APE8-rot-out 67.26 APE67-dihe-out 104.99, -2.33 -121.34, -117.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.736 0.197 0.235 B 431 374 25 0 0 19 [[571, 832]] 1.0 6w39 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3AA O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.687 14.75 BLBplus DFGAsp-rot-in -159.03, 176.32 57.32, 40.69 198.07, 32.79 -104.35, 145.33 50.26, 89.45 73.99, 38.41 in-in in 8.719 Saltbr-in 2.941 HRD-in -70.5, -44.05 68.58, -4.98 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.79 APE8-dihe-out -141.14, -179.39 APE8-rot-out 65.3 APE67-dihe-out 122.02, -15.91 -119.08, -128.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.577 None None None XRAY 2.606 0.249 0.29 A 434 363 32 0 0 18 [[571, 832]] 1.0 6w3a Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3AB O75460 562 964 977.0 SJM:1001 Type1 Inactive DFGin 4.444 14.584 BLBplus DFGAsp-rot-in -150.2, 175.33 54.85, 42.0 202.33, 39.76 -103.74, 137.1 52.82, 87.58 88.2, 19.62 in-out in 8.543 Saltbr-out 3.645 HRD-in -69.7, -38.0 68.52, -8.14 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.7 APE8-dihe-out -126.01, -171.29 APE8-rot-out 66.29 APE67-dihe-out 116.07, -16.83 -111.97, -139.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.654 None None None XRAY 2.606 0.249 0.29 B 434 371 25 0 0 17 [[571, 832]] 1.0 6w3a Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GA O75460 562 963 977.0 No_ligand No_ligand Inactive DFGin 4.996 14.533 None DFGAsp-rot-out -140.81, 175.34 43.48, 101.03 332.01, -33.09 -87.72, 999.0 308.92, 94.22 999.0, 999.0 in-in in 8.947 Saltbr-in 2.84 HRD-in -60.57, -47.56 72.24, -10.39 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, -18.99 APE9-dihe-na -167.3, -173.38 APE8-dihe-in -130.49, 124.62 APE8-rot-out 52.96 APE67-dihe-inflip 106.42, -11.92 -35.23, 118.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.834 None None None XRAY 2.6 0.204 0.226 A 416 366 26 0 0 19 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7GB O75460 562 962 977.0 No_ligand No_ligand Inactive DFGin 4.91 14.386 None DFGAsp-rot-out -141.89, 174.99 45.35, 92.04 295.13, -84.28 -84.88, 999.0 313.4, 110.77 999.0, 999.0 in-in in 8.916 Saltbr-in 2.832 HRD-in -60.96, -47.53 72.73, -11.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -63.92, -20.1 APE9-dihe-na -168.1, 175.6 APE8-dihe-in -122.17, 125.73 APE8-rot-out 53.21 APE67-dihe-inflip 110.25, -18.1 -36.38, 118.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.835 None None None XRAY 2.6 0.204 0.226 B 416 377 24 0 0 18 [[571, 832]] 1.0 4z7g Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4Z7HA O75460 562 963 977.0 4L5:1001 Type1 Inactive DFGin 5.393 14.977 None DFGAsp-rot-in -138.87, -45.43 -76.98, 88.77 226.44, -27.39 -83.95, 3.75 273.49, 77.38 -61.03, -41.59 in-in in 8.851 Saltbr-in 2.809 HRD-in -73.17, -46.77 63.73, 3.56 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -6.85 APE9-dihe-na 151.6, -155.97 APE8-dihe-in -123.5, 123.79 APE8-rot-out 45.5 APE67-dihe-inflip 106.26, -20.23 -56.36, 141.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.613 APE9-dist-in 4.646 None None None XRAY 2.9 0.202 0.225 A 416 385 10 0 0 5 [[571, 832]] 1.0 4z7h Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.93 7.257 None DFGAsp-rot-in -145.42, 154.32 -79.25, -25.27 169.85, 66.54 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.782 None None None XRAY 2.463 0.238 0.283 A 405 381 22 0 0 17 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.04 7.266 None DFGAsp-rot-in -150.4, 164.44 -74.79, -40.79 159.24, 51.75 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.359 Saltbr-out 7.616 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405 375 24 0 0 19 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.11 None DFGAsp-rot-out -135.14, 175.91 -93.49, -10.88 55.66, -53.54 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.749 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405 378 25 0 0 18 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6HX1A O75460 562 964 977.0 GXK:1001 Type1 Inactive None 999.0 9.031 None DFGAsp-rot-out -117.25, 153.54 -78.62, -34.04 54.08, -25.55 -91.96, 133.47 286.33, 72.45 -93.93, 146.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.4, -55.14 79.73, -2.12 none-out-out SNCnoo out-out ActLoopNT-out 22.478 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -51.71, 130.91 APE9-dihe-na 103.58, -28.73 APE8-dihe-out -114.51, 37.72 APE8-rot-out 76.32 APE67-dihe-in -78.77, 3.79 -81.24, -41.88 APE12-dist-in 12.341 APE11-dist-in 9.378 APE10-dist-out 11.323 APE9-dist-out 15.695 None None None XRAY 2.14 0.219 0.268 A 403 387 16 0 0 2 [[571, 832]] 1.0 6hx1 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6HV0A O75460 562 963 977.0 GUK:1001 Type1 Inactive None 999.0 9.182 None DFGAsp-rot-out -133.1, 153.75 -66.3, -48.4 338.01, -79.32 -89.37, 135.79 292.63, 70.49 -93.67, 142.5 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.37, -40.56 70.66, -13.49 none-out-out SNCnoo out-out ActLoopNT-out 22.512 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -88.59, 128.96 APE9-dihe-na -116.2, 97.18 APE8-dihe-out -118.13, -15.29 APE8-rot-in 276.8 APE67-dihe-inflip 101.83, -26.03 -49.76, 144.64 APE12-dist-in 12.836 APE11-dist-in 10.086 APE10-dist-out 11.662 APE9-dist-out 15.745 None None None XRAY 2.73 0.217 0.269 A 416 377 23 0 0 0 [[571, 832]] 1.0 6hv0 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.1e-35 128.0 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN2 ERN2_HUMAN AF-Q76MJ5-K1A Q76MJ5 510 789 926.0 No_ligand No_ligand Active DFGin 5.368 14.29 BLAminus DFGAsp-rot-in -135.16, 175.78 56.74, 78.02 199.18, 16.08 -85.53, 10.57 279.65, 57.28 -61.02, -29.35 in-in in 8.696 Saltbr-in 2.646 HRD-in -73.42, -46.06 62.52, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.28, 151.27 APE9-dihe-na 120.63, 170.37 APE8-dihe-in -93.63, 136.3 APE8-rot-in 303.23 APE67-dihe-inflip 84.69, -7.7 -49.91, 132.98 APE12-dist-in 10.985 APE11-dist-in 11.126 APE10-dist-in 5.34 APE9-dist-in 3.31 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[520, 781]] 1.0 AF-Q76MJ5-K1 Homo sapiens OTHER_ERN2_HUMAN CAMK 1.9e-33 121.8 4 256 253 659 660 661 663 665 548 561 565 634 636 635 637 705 690 685 684 683 682 681 680 679 592 Serine/threonine-protein kinase/endoribonuclease IRE2
OTHER ERN2 ERN2_HUMAN AF-Q76MJ5-K3A Q76MJ5 510 789 926.0 No_ligand No_ligand Active DFGin 5.202 14.149 BLAminus DFGAsp-rot-in -133.23, 178.12 57.36, 72.26 201.92, 14.29 -80.59, 4.94 281.49, 67.16 -60.5, -31.63 in-in in 8.569 Saltbr-in 2.641 HRD-in -72.7, -48.8 67.08, -3.82 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.36, 145.49 APE9-dihe-na 122.75, -170.94 APE8-dihe-in -109.07, 136.09 APE8-rot-in 299.3 APE67-dihe-inflip 80.11, -5.41 -51.08, 134.07 APE12-dist-in 10.76 APE11-dist-in 11.181 APE10-dist-in 5.554 APE9-dist-in 3.145 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[520, 781]] 1.0 AF-Q76MJ5-K3 Homo sapiens OTHER_ERN2_HUMAN CAMK 1.9e-33 121.8 4 256 253 659 660 661 663 665 548 561 565 634 636 635 637 705 690 685 684 683 682 681 680 679 592 Serine/threonine-protein kinase/endoribonuclease IRE2
OTHER GAK GAK_HUMAN 4O38A O14976 25 334 1311.0 No_ligand No_ligand Inactive DFGin 5.659 13.735 ABAminus DFGAsp-rot-out -138.06, -2.27 -113.83, 85.58 50.35, -28.87 -104.61, 19.83 303.3, 120.26 -68.6, -17.05 in-in in 8.916 Saltbr-in 2.609 HRD-in -79.1, -51.28 74.73, -0.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE89,MSE137,MSE162,MSE225,MSE295 XRAY 2.097 0.166 0.195 A 338 267 43 0 0 28 [[40, 313]] 1.0 4o38 Homo sapiens OTHER_GAK_HUMAN CAMK 5.4e-44 156.8 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4O38B O14976 26 337 1311.0 No_ligand No_ligand Inactive DFGin 5.602 13.735 ABAminus DFGAsp-rot-out -142.92, -2.71 -112.18, 83.29 52.57, -29.29 -104.79, 22.19 305.95, 119.3 -69.31, -19.55 in-in in 8.972 Saltbr-in 2.62 HRD-in -73.83, -51.42 73.13, -3.06 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE89,MSE137,MSE162,MSE225,MSE295 XRAY 2.097 0.166 0.195 B 338 276 36 0 0 24 [[40, 313]] 1.0 4o38 Homo sapiens OTHER_GAK_HUMAN CAMK 5.4e-44 156.8 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZA O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.183 14.302 ABAminus DFGAsp-rot-in -120.31, -65.73 -84.03, 133.07 201.13, -48.13 -132.73, 38.63 297.55, 94.83 -80.73, -23.71 in-in in 9.33 Saltbr-in 2.653 HRD-in -76.12, -47.1 64.19, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.58, 12.1 APE9-dihe-na -127.21, 155.97 APE8-dihe-in -88.88, 126.92 APE8-rot-in 301.28 APE67-dihe-in -75.82, -11.44 -39.58, -53.85 APE12-dist-in 11.675 APE11-dist-in 8.741 APE10-dist-in 4.165 APE9-dist-in 4.146 None None None XRAY 2.804 0.235 0.288 A 313 311 0 0 0 0 [[40, 313]] 1.0 5y7z Homo sapiens OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y7ZB O14976 25 335 1311.0 IRE:60401 Type1 Inactive DFGin 6.185 14.3 ABAminus DFGAsp-rot-in -126.63, -59.42 -85.24, 119.57 194.9, -84.95 -121.34, 32.24 292.7, 91.36 -76.51, -21.75 in-in in 8.998 Saltbr-in 3.336 HRD-in -76.77, -44.95 63.95, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.15, 9.34 APE9-dihe-na -125.96, 148.71 APE8-dihe-in -79.22, 127.62 APE8-rot-in 300.16 APE67-dihe-in -76.26, -13.67 -39.68, -52.24 APE12-dist-in 11.771 APE11-dist-in 8.765 APE10-dist-in 4.231 APE9-dist-in 4.002 None None None XRAY 2.804 0.235 0.288 B 313 311 0 0 0 0 [[40, 313]] 1.0 5y7z Homo sapiens OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.754 14.141 ABAminus DFGAsp-rot-in -112.53, -37.31 -102.07, 134.52 194.59, 87.18 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.993 Saltbr-out 4.057 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.779 APE11-dist-in 8.573 APE10-dist-in 4.33 APE9-dist-in 4.07 None None None XRAY 2.55 0.18 0.228 A 340 310 0 0 0 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.769 14.233 ABAminus DFGAsp-rot-in -105.07, -37.59 -101.51, 133.86 195.58, 86.45 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.065 Saltbr-out 4.056 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.928 APE11-dist-in 8.658 APE10-dist-in 4.358 APE9-dist-in 4.086 None None None XRAY 2.55 0.18 0.228 B 340 308 0 0 0 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.815 13.68 ABAminus DFGAsp-rot-out -134.62, -10.32 -105.18, 88.43 56.13, -28.88 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.093 Saltbr-in 2.855 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.838 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340 266 41 0 0 27 [[40, 313]] 1.0 4c59 Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 5Y80A O14976 25 332 1311.0 IRE:60401,IRE:60402 Type1,Allosteric Inactive DFGin 6.283 14.516 ABAminus DFGAsp-rot-in -119.77, -54.31 -90.82, 110.26 200.33, -45.28 -111.11, 18.56 296.38, 94.44 -67.28, -25.31 in-in in 8.858 Saltbr-in 3.281 HRD-in -69.89, -47.62 68.73, -10.18 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.53, 10.66 APE9-dihe-na -135.16, 171.64 APE8-dihe-in -123.07, 133.96 APE8-rot-in 293.66 APE67-dihe-in -69.42, -14.72 -40.65, -51.06 APE12-dist-out 14.946 APE11-dist-in 13.254 APE10-dist-out 8.056 APE9-dist-out 7.473 None None None XRAY 2.5 0.232 0.282 A 313 305 3 0 0 0 [[40, 313]] 1.0 5y80 Homo sapiens OTHER_GAK_HUMAN CAMK 4.1e-44 157.2 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C58A O14976 27 333 1311.0 824:1336 Type1.5_Back Inactive DFGin 5.777 13.798 ABAminus DFGAsp-rot-out -132.89, -19.04 -95.75, 85.27 49.95, -26.27 -100.86, 19.52 307.21, 107.98 -74.39, -16.9 in-in in 8.74 Saltbr-in 2.956 HRD-in -74.87, -50.0 69.14, -1.84 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.16 0.182 0.242 A 340 267 40 0 0 27 [[40, 313]] 1.0 4c58 Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN AF-O14976-K1A O14976 32 323 1311.0 No_ligand No_ligand Active DFGin 5.84 13.848 BLAminus DFGAsp-rot-in -133.45, 179.28 63.44, 74.32 200.17, 15.75 -88.75, 11.98 300.95, 94.46 -62.76, -26.27 in-in in 9.142 Saltbr-in 2.717 HRD-in -75.98, -39.23 66.88, -25.57 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.79, 15.15 APE9-dihe-na -139.7, 139.56 APE8-dihe-in -75.05, 126.47 APE8-rot-in 295.45 APE67-dihe-in -68.97, -25.92 -48.51, -43.87 APE12-dist-in 11.773 APE11-dist-in 8.649 APE10-dist-in 4.333 APE9-dist-in 3.787 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[40, 313]] 1.0 AF-O14976-K1 Homo sapiens OTHER_GAK_HUMAN CAMK 3.2e-44 157.5 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN AF-O14976-K3A O14976 32 323 1311.0 No_ligand No_ligand Active DFGin 5.703 13.574 BLAminus DFGAsp-rot-in -134.69, -175.6 59.61, 75.73 198.95, 23.71 -91.2, 13.21 303.62, 95.59 -60.85, -31.12 in-in in 8.973 Saltbr-in 2.659 HRD-in -75.64, -41.0 67.38, -33.91 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.15, 16.85 APE9-dihe-na -144.17, 136.49 APE8-dihe-in -72.61, 126.92 APE8-rot-in 297.17 APE67-dihe-in -69.9, -24.24 -50.23, -46.59 APE12-dist-in 11.897 APE11-dist-in 8.52 APE10-dist-in 4.415 APE9-dist-in 4.26 None None None AF2 -1.0 1.0 1.0 A 292 292 0 0 0 0 [[40, 313]] 1.0 AF-O14976-K3 Homo sapiens OTHER_GAK_HUMAN CAMK 3.2e-44 157.5 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DA O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.562 13.518 BLAminus DFGAsp-rot-in -138.4, -164.21 74.62, 66.04 199.54, -60.61 -93.04, 16.88 304.79, 110.01 -68.29, -18.06 in-in in 8.973 Saltbr-in 2.822 HRD-in -78.84, -52.81 74.15, 0.63 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 A 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DB O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.558 13.438 BLAminus DFGAsp-rot-in -140.66, -164.98 74.22, 67.3 200.82, -62.27 -94.1, 19.71 305.39, 110.44 -72.07, -18.1 in-in in 8.927 Saltbr-in 2.81 HRD-in -76.85, -53.12 74.48, -1.34 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 B 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 3DLZA Q8TF76 470 798 798.0 AMP:902 ATPlike Active DFGin 5.254 12.469 BLAminus DFGAsp-rot-in -120.14, 174.05 73.32, 91.07 190.81, 8.01 -105.92, 29.14 315.79, 130.04 -57.27, -36.15 in-in in 9.264 Saltbr-in 2.695 HRD-na-N -71.0, -49.07 68.99, 3.03 in-in-na SNCiia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -122.28, 17.39 APE9-dihe-na -67.57, 157.85 APE8-dihe-na -149.51, 177.99 APE8-rot-na 58.52 APE67-dihe-na -159.03, 144.74 95.06, -6.22 APE12-dist-na 9.493 APE11-dist-na 13.466 APE10-dist-na 17.05 APE9-dist-na 12.819 None None None XRAY 1.85 0.167 0.216 A 357 329 0 0 0 0 [[484, 797]] 1.0 3dlz Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN AF-Q8TF76-K1A Q8TF76 476 798 798.0 No_ligand No_ligand Active DFGin 4.997 12.374 BLAminus DFGAsp-rot-in -138.62, 174.68 57.97, 91.28 208.87, -40.4 -100.94, 21.93 314.77, 120.9 -55.94, -45.23 in-in in 9.18 Saltbr-in 2.711 HRD-na-N -75.36, -43.16 61.41, 5.31 in-in-na SNCiia in-na ActLoopNT-in 2.839 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.17, -12.71 APE9-dihe-na -54.03, 150.53 APE8-dihe-na -147.69, 169.0 APE8-rot-na 193.38 APE67-dihe-na -135.11, 149.27 98.64, -16.5 APE12-dist-na 9.305 APE11-dist-na 13.309 APE10-dist-na 16.98 APE9-dist-na 12.992 None None None AF2 -1.0 1.0 1.0 A 323 323 0 0 0 0 [[484, 797]] 1.0 AF-Q8TF76-K1 Homo sapiens OTHER_HASPIN_HUMAN HASP 9.5e-227 757.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN AF-Q8TF76-K3A Q8TF76 476 798 798.0 No_ligand No_ligand Active DFGin 4.951 12.431 BLAminus DFGAsp-rot-in -133.71, 176.01 54.85, 96.46 208.95, -47.1 -104.75, 21.31 315.54, 124.63 -56.24, -41.59 in-in in 9.299 Saltbr-in 2.719 HRD-na-N -75.19, -42.52 61.0, 1.07 in-in-na SNCiia in-na ActLoopNT-in 2.885 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.31, -18.43 APE9-dihe-na -56.71, 155.17 APE8-dihe-na -141.59, -175.7 APE8-rot-na 73.98 APE67-dihe-na -125.54, 149.77 84.64, -25.13 APE12-dist-na 9.207 APE11-dist-na 13.228 APE10-dist-na 16.926 APE9-dist-na 13.133 None None None AF2 -1.0 1.0 1.0 A 323 323 0 0 0 0 [[484, 797]] 1.0 AF-Q8TF76-K3 Homo sapiens OTHER_HASPIN_HUMAN HASP 9.5e-227 757.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 2WB8A Q8TF76 447 798 798.0 No_ligand No_ligand Active DFGin 5.22 12.191 BLAminus DFGAsp-rot-in -120.69, 176.87 68.15, 91.75 182.81, 7.12 -104.26, 25.9 315.71, 126.12 -56.01, -32.87 in-in in 9.095 Saltbr-in 2.281 HRD-na-N -69.54, -53.11 72.35, 6.09 in-in-na SNCiia in-na ActLoopNT-in 2.857 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -129.5, 34.17 APE9-dihe-na -83.79, 164.98 APE8-dihe-na -149.79, 174.65 APE8-rot-na 31.25 APE67-dihe-na -168.04, 143.08 80.64, 14.62 APE12-dist-na 9.206 APE11-dist-na 12.948 APE10-dist-na 16.727 APE9-dist-na 12.724 None None None XRAY 2.15 0.23 0.267 A 352 351 1 0 0 0 [[484, 797]] 1.0 2wb8 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.3e-226 756.7 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 5HTBA Q8TF76 471 798 798.0 No_ligand No_ligand Active DFGin 4.886 12.713 BLAminus DFGAsp-rot-in -127.82, 172.38 75.8, 95.98 197.2, -43.07 -111.9, 24.65 313.35, 119.25 -57.64, -36.0 in-in in 9.095 Saltbr-in 2.722 HRD-na-N -72.45, -46.3 70.77, -0.27 in-in-na SNCiia in-na ActLoopNT-in 2.859 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.52, 17.28 APE9-dihe-na -71.3, 162.17 APE8-dihe-na -148.2, 163.96 APE8-rot-na 208.0 APE67-dihe-na -159.11, 139.67 91.05, 1.41 APE12-dist-na 9.417 APE11-dist-na 13.298 APE10-dist-na 16.873 APE9-dist-na 12.933 None None None XRAY 1.7 0.163 0.181 A 357 328 0 0 0 0 [[484, 797]] 1.0 5htb Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 5HTCA Q8TF76 471 798 798.0 No_ligand No_ligand Active DFGin 5.008 12.77 BLAminus DFGAsp-rot-in -124.68, 170.56 74.88, 95.44 186.86, 13.38 -108.39, 22.99 316.66, 123.43 -55.96, -37.72 in-in in 9.222 Saltbr-in 2.671 HRD-na-N -71.81, -49.47 73.17, 0.66 in-in-na SNCiia in-na ActLoopNT-in 2.875 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.86, 18.07 APE9-dihe-na -74.58, 161.83 APE8-dihe-na -153.14, 168.43 APE8-rot-na 79.76 APE67-dihe-na -159.07, 137.97 97.79, -1.9 APE12-dist-na 9.518 APE11-dist-na 13.376 APE10-dist-na 16.983 APE9-dist-na 12.965 None None None XRAY 1.5 0.151 0.171 A 357 328 0 0 0 0 [[484, 797]] 1.0 5htc Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2SK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 6.064 12.671 BLAminus DFGAsp-rot-in -142.15, 178.43 60.64, 69.74 203.46, 17.96 -94.32, 35.13 330.57, 110.31 -71.54, -20.41 out-out out 10.509 Saltbr-out 8.91 HRD-na-N -103.48, -39.3 72.01, 16.12 out-in-na SNCoia in-na ActLoopNT-in 2.662 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -93.15, 4.32 APE9-dihe-na -71.11, 161.22 APE8-dihe-na -159.47, 164.4 APE8-rot-na 76.0 APE67-dihe-na -157.32, 146.25 103.48, -10.17 APE12-dist-na 10.384 APE11-dist-na 14.356 APE10-dist-na 17.698 APE9-dist-na 13.728 None None None EM 3.01 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2s Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2UK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 5.926 12.627 BLAminus DFGAsp-rot-in -136.69, -178.38 59.48, 67.33 187.97, 1.77 -92.11, 31.61 333.66, 107.16 -67.05, -16.22 out-out out 10.457 Saltbr-out 8.398 HRD-na-N -100.22, -40.69 78.07, 2.57 out-in-na SNCoia in-na ActLoopNT-in 2.756 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -100.28, 9.24 APE9-dihe-na -71.6, 162.97 APE8-dihe-na -157.23, 160.72 APE8-rot-na 81.21 APE67-dihe-na -151.55, 148.6 98.32, -9.69 APE12-dist-na 10.577 APE11-dist-na 14.628 APE10-dist-na 17.968 APE9-dist-na 13.833 None None None EM 3.64 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2u Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G39A Q8TF76 471 798 798.0 5ID:802 Type1 Active DFGin 5.021 12.32 BLAminus DFGAsp-rot-in -127.21, 173.16 74.1, 91.77 190.52, 2.48 -104.6, 25.15 318.27, 124.04 -54.52, -37.44 in-in in 9.223 Saltbr-in 2.607 HRD-na-N -72.86, -48.93 72.97, 0.92 in-in-na SNCiia in-na ActLoopNT-in 2.865 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.61, 13.68 APE9-dihe-na -74.05, 162.55 APE8-dihe-na -147.53, 161.22 APE8-rot-na 206.35 APE67-dihe-na -163.09, 139.78 96.44, 2.71 APE12-dist-na 9.496 APE11-dist-na 13.491 APE10-dist-na 16.919 APE9-dist-na 13.026 F605Y None None XRAY 1.45 0.159 0.175 A 357 328 0 0 0 0 [[484, 797]] 1.0 6g39 Homo sapiens OTHER_HASPIN_HUMAN HASP 4e-226 755.1 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 2VUWA Q8TF76 470 798 798.0 5ID:1800 Type1 Active DFGin 4.977 12.344 BLAminus DFGAsp-rot-in -126.7, 172.42 73.13, 94.6 197.35, -11.33 -106.22, 25.34 317.03, 123.17 -59.06, -30.58 in-in in 9.293 Saltbr-in 2.791 HRD-na-N -69.06, -49.8 71.93, -0.86 in-in-na SNCiia in-na ActLoopNT-in 2.886 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.41, 21.25 APE9-dihe-na -74.65, 162.69 APE8-dihe-na -150.22, 164.21 APE8-rot-na 197.92 APE67-dihe-na -163.26, 143.62 93.5, 5.23 APE12-dist-na 9.51 APE11-dist-na 13.492 APE10-dist-na 17.046 APE9-dist-na 12.946 None None MSE615,MSE706,MSE725,MSE752,MSE756,MSE767,MSE781 XRAY 1.8 0.148 0.169 A 336 329 0 0 0 0 [[484, 797]] 1.0 2vuw Homo sapiens OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.178 12.218 BLAminus DFGAsp-rot-in -141.02, 178.95 59.99, 70.73 184.73, 7.85 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.759 Saltbr-in 2.463 HRD-na-N -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.905 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.64 APE11-dist-na 13.509 APE10-dist-na 17.247 APE9-dist-na 13.279 None None None XRAY 2.4 0.187 0.239 A 336 320 8 0 0 0 [[484, 797]] 1.0 9flt Homo sapiens OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3E7VA Q8TF76 471 798 798.0 DZO:1 Type1 Active DFGin 5.227 12.203 BLAminus DFGAsp-rot-in -130.14, 169.21 72.6, 84.89 205.6, 11.73 -101.25, 35.48 316.82, 123.9 -62.16, -34.97 in-in in 9.014 Saltbr-in 2.481 HRD-na-N -68.11, -48.56 71.09, -0.57 in-in-na SNCiia in-na ActLoopNT-in 2.917 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -113.43, 18.49 APE9-dihe-na -73.97, 165.86 APE8-dihe-na -158.09, 152.51 APE8-rot-na 206.55 APE67-dihe-na -159.89, 140.52 100.1, 0.81 APE12-dist-na 9.459 APE11-dist-na 13.36 APE10-dist-na 17.023 APE9-dist-na 12.905 None None None XRAY 2.0 0.17 0.225 A 357 328 0 0 0 0 [[484, 797]] 1.0 3e7v Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3F2NA Q8TF76 471 798 798.0 IZZ:800 Type1 Active DFGin 5.227 12.509 BLAminus DFGAsp-rot-in -132.35, 169.14 74.56, 87.66 192.8, -31.19 -98.09, 25.18 316.3, 125.75 -57.05, -34.51 in-in in 8.729 Saltbr-in 2.737 HRD-na-N -71.51, -49.79 70.28, -0.25 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -120.07, 21.25 APE9-dihe-na -75.2, 162.89 APE8-dihe-na -156.01, 176.32 APE8-rot-na 74.11 APE67-dihe-na -157.24, 143.14 98.22, -8.69 APE12-dist-na 9.565 APE11-dist-na 13.531 APE10-dist-na 17.149 APE9-dist-na 12.969 None None None XRAY 1.8 0.162 0.186 A 357 328 0 0 0 0 [[484, 797]] 1.0 3f2n Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3FMDA Q8TF76 470 798 798.0 IQB:1 Type1 Active DFGin 4.817 12.737 BLAminus DFGAsp-rot-in -134.95, 173.12 69.12, 93.36 201.31, -6.37 -108.33, 23.11 309.03, 122.86 -58.61, -32.84 in-in in 9.417 Saltbr-in 2.578 HRD-na-N -64.91, -44.59 67.0, -1.51 in-in-na SNCiia in-na ActLoopNT-in 2.86 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -126.4, 30.5 APE9-dihe-na -82.22, 168.97 APE8-dihe-na -156.73, 170.22 APE8-rot-na 87.7 APE67-dihe-na -158.09, 144.39 88.76, -6.79 APE12-dist-na 9.533 APE11-dist-na 13.423 APE10-dist-na 17.115 APE9-dist-na 13.017 None None None XRAY 2.0 0.226 0.283 A 357 329 0 0 0 0 [[484, 797]] 1.0 3fmd Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 3IQ7A Q8TF76 471 798 798.0 5ID:799 Type1 Active DFGin 5.002 12.525 BLAminus DFGAsp-rot-in -130.14, 168.59 78.5, 93.8 191.01, 4.6 -107.03, 26.88 317.14, 123.36 -63.63, -28.13 in-in in 9.288 Saltbr-in 2.716 HRD-na-N -69.08, -54.14 69.34, 3.59 in-in-na SNCiia in-na ActLoopNT-in 2.842 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -119.96, 19.66 APE9-dihe-na -73.26, 163.53 APE8-dihe-na -151.13, 165.69 APE8-rot-na 217.79 APE67-dihe-na -160.55, 141.37 91.74, 4.08 APE12-dist-na 9.31 APE11-dist-na 13.171 APE10-dist-na 16.954 APE9-dist-na 12.798 None None None XRAY 2.0 0.174 0.207 A 357 328 0 0 0 0 [[484, 797]] 1.0 3iq7 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 4OUCA Q8TF76 470 798 798.0 5ID:60808 Type1 Active DFGin 5.142 12.398 BLAminus DFGAsp-rot-in -123.14, 171.36 70.83, 89.85 195.48, -4.24 -103.14, 24.75 317.85, 126.13 -50.7, -43.23 in-in in 9.227 Saltbr-in 2.635 HRD-na-N -73.5, -49.82 73.73, 4.15 in-in-na SNCiia in-na ActLoopNT-in 2.897 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.93, 10.97 APE9-dihe-na -70.72, 155.25 APE8-dihe-na -144.93, 165.92 APE8-rot-na 81.62 APE67-dihe-na -154.34, 142.15 101.34, -0.24 APE12-dist-na 9.521 APE11-dist-na 13.627 APE10-dist-na 17.119 APE9-dist-na 12.997 None None None XRAY 1.9 0.166 0.211 A 357 329 0 0 0 0 [[484, 797]] 1.0 4ouc Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 4QTCA Q8TF76 469 798 798.0 38Z:804 Type1 Active DFGin 4.743 12.697 BLAminus DFGAsp-rot-in -128.25, 174.11 72.8, 94.29 184.0, 9.68 -100.86, 22.55 311.48, 126.56 -49.88, -46.32 in-in in 9.244 Saltbr-in 2.767 HRD-na-N -70.64, -49.71 73.49, 0.07 in-in-na SNCiia in-na ActLoopNT-in 2.862 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.14, 15.58 APE9-dihe-na -74.4, 166.34 APE8-dihe-na -155.61, 167.98 APE8-rot-na 54.8 APE67-dihe-na -159.6, 141.49 96.89, -1.32 APE12-dist-na 9.4 APE11-dist-na 13.293 APE10-dist-na 16.89 APE9-dist-na 13.142 None None None XRAY 1.4 0.15 0.164 A 357 330 0 0 0 0 [[484, 797]] 1.0 4qtc Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G34A Q8TF76 472 798 798.0 5ID:60401 Type1 Active DFGin 4.991 12.367 BLAminus DFGAsp-rot-in -127.35, 171.15 74.89, 93.11 193.36, -5.12 -104.99, 26.96 316.16, 126.1 -57.37, -32.12 in-in in 9.292 Saltbr-in 2.721 HRD-na-N -71.53, -47.32 70.63, -2.3 in-in-na SNCiia in-na ActLoopNT-in 2.893 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.68, 18.32 APE9-dihe-na -70.1, 157.86 APE8-dihe-na -146.1, 158.98 APE8-rot-na 202.21 APE67-dihe-na -162.15, 141.91 96.58, 0.13 APE12-dist-na 9.436 APE11-dist-na 13.462 APE10-dist-na 16.952 APE9-dist-na 12.837 None None None XRAY 1.76 0.14 0.174 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g34 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G35A Q8TF76 465 798 798.0 EKK:60802 Type1 Active DFGin 5.005 12.39 BLAminus DFGAsp-rot-in -126.0, 169.52 78.13, 90.25 192.22, 1.12 -104.66, 24.26 315.74, 125.01 -60.88, -28.25 in-in in 9.306 Saltbr-in 2.713 HRD-na-N -70.57, -49.54 72.42, 1.39 in-in-na SNCiia in-na ActLoopNT-in 2.901 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.32, 17.8 APE9-dihe-na -73.2, 161.57 APE8-dihe-na -146.96, 162.71 APE8-rot-na 196.59 APE67-dihe-na -162.63, 137.82 97.88, 1.51 APE12-dist-na 9.478 APE11-dist-na 13.461 APE10-dist-na 17.008 APE9-dist-na 13.016 None None None XRAY 1.55 0.161 0.183 A 357 334 0 0 0 0 [[484, 797]] 1.0 6g35 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G36A Q8TF76 465 798 798.0 EKH:60401 Type1 Active DFGin 4.952 12.328 BLAminus DFGAsp-rot-in -126.44, 170.29 76.27, 92.19 194.23, -9.74 -105.23, 26.61 316.28, 124.1 -57.25, -32.63 in-in in 9.282 Saltbr-in 2.744 HRD-na-N -71.83, -48.64 74.84, -0.58 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.55, 15.17 APE9-dihe-na -70.08, 160.85 APE8-dihe-na -149.64, 167.11 APE8-rot-na 67.1 APE67-dihe-na -162.45, 137.7 92.15, 4.46 APE12-dist-na 9.491 APE11-dist-na 13.449 APE10-dist-na 17.015 APE9-dist-na 12.972 None None None XRAY 1.46 0.151 0.176 A 357 334 0 0 0 0 [[484, 797]] 1.0 6g36 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G37A Q8TF76 472 798 798.0 FTU:801 Type1 Active DFGin 5.035 12.401 BLAminus DFGAsp-rot-in -125.49, 171.67 75.49, 90.88 194.91, -8.41 -104.56, 25.99 317.99, 122.48 -54.51, -35.12 in-in in 9.318 Saltbr-in 2.736 HRD-na-N -70.97, -50.1 72.78, 2.06 in-in-na SNCiia in-na ActLoopNT-in 2.889 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.17, 14.96 APE9-dihe-na -72.53, 161.37 APE8-dihe-na -147.52, 165.41 APE8-rot-na 216.83 APE67-dihe-na -159.62, 143.17 92.11, 0.24 APE12-dist-na 9.422 APE11-dist-na 13.433 APE10-dist-na 16.884 APE9-dist-na 12.914 None None None XRAY 1.48 0.149 0.167 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g37 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G38A Q8TF76 472 798 798.0 TBN:800 Type1 Active DFGin 5.155 12.468 BLAminus DFGAsp-rot-in -124.6, 171.17 73.49, 90.96 197.82, -19.25 -102.58, 23.98 318.22, 128.64 -60.91, -27.39 in-in in 9.286 Saltbr-in 2.681 HRD-na-N -70.12, -48.6 70.78, 0.07 in-in-na SNCiia in-na ActLoopNT-in 2.865 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.63, 17.26 APE9-dihe-na -74.94, 161.54 APE8-dihe-na -150.43, 171.99 APE8-rot-na 81.52 APE67-dihe-na -161.74, 140.31 94.52, 1.17 APE12-dist-na 9.54 APE11-dist-na 13.547 APE10-dist-na 17.024 APE9-dist-na 13.008 None None None XRAY 1.47 0.144 0.165 A 357 327 0 0 0 0 [[484, 797]] 1.0 6g38 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z57A Q8TF76 470 798 798.0 Q8W:801 Type1 Active DFGin 5.108 12.544 BLAminus DFGAsp-rot-in -128.55, 170.14 70.49, 89.65 193.32, -5.8 -99.72, 23.55 319.85, 122.5 -60.24, -32.24 in-in in 9.047 Saltbr-in 2.63 HRD-na-N -69.51, -48.64 73.21, 1.64 in-in-na SNCiia in-na ActLoopNT-in 2.906 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.13, 24.13 APE9-dihe-na -80.04, 165.59 APE8-dihe-na -154.67, 168.36 APE8-rot-na 59.7 APE67-dihe-na -158.19, 141.65 89.15, 3.9 APE12-dist-na 9.623 APE11-dist-na 13.634 APE10-dist-na 17.184 APE9-dist-na 13.001 None None None XRAY 1.5 0.164 0.188 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z57 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z58A Q8TF76 470 798 798.0 Q9B:801 Type1 Active DFGin 5.29 11.882 BLAminus DFGAsp-rot-in -131.62, 178.98 63.69, 89.83 194.02, -3.26 -101.06, 25.15 318.41, 128.59 -53.25, -41.36 in-in in 8.999 Saltbr-in 2.668 HRD-na-N -74.24, -49.55 73.51, 2.01 in-in-na SNCiia in-na ActLoopNT-in 2.86 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.26, 20.54 APE9-dihe-na -78.55, 163.28 APE8-dihe-na -149.94, 172.24 APE8-rot-na 51.88 APE67-dihe-na -158.7, 145.23 97.38, -8.51 APE12-dist-na 9.654 APE11-dist-na 13.592 APE10-dist-na 17.186 APE9-dist-na 13.103 None None None XRAY 1.8 0.164 0.19 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z58 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z59A Q8TF76 471 798 798.0 Q98:801 Type1 Active DFGin 5.136 12.054 BLAminus DFGAsp-rot-in -130.43, 175.42 66.1, 93.37 197.62, -1.34 -104.47, 26.06 315.68, 130.09 -58.56, -40.67 in-in in 9.082 Saltbr-in 2.794 HRD-na-N -73.99, -49.28 75.88, 2.33 in-in-na SNCiia in-na ActLoopNT-in 2.831 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.38, 14.19 APE9-dihe-na -67.33, 158.61 APE8-dihe-na -154.66, -177.03 APE8-rot-na 74.44 APE67-dihe-na -159.78, 146.47 89.13, -0.56 APE12-dist-na 9.712 APE11-dist-na 13.618 APE10-dist-na 17.166 APE9-dist-na 12.987 None None None XRAY 2.0 0.201 0.24 A 357 328 0 0 0 0 [[484, 797]] 1.0 6z59 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5CA Q8TF76 470 798 798.0 PQ5:805 Type1 Inactive DFGin 4.731 13.108 BLAminus DFGAsp-rot-in -133.84, 170.31 75.72, 94.52 187.57, -0.13 -110.21, 19.19 311.37, 116.86 -61.87, -31.19 out-out out 10.462 Saltbr-out 3.7 HRD-na-N -70.06, -50.84 74.01, -0.31 out-in-na SNCoia in-na ActLoopNT-in 2.931 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.88, 20.45 APE9-dihe-na -80.43, 159.13 APE8-dihe-na -144.39, 165.92 APE8-rot-na 214.89 APE67-dihe-na -162.19, 147.1 97.48, -3.07 APE12-dist-na 9.488 APE11-dist-na 13.52 APE10-dist-na 17.05 APE9-dist-na 13.1 None None None XRAY 1.75 0.16 0.188 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z5c Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5DA Q8TF76 470 798 798.0 Q8Q:805 Type1 Active DFGin 5.053 12.308 BLAminus DFGAsp-rot-in -128.1, 170.45 73.65, 93.08 192.23, 0.69 -105.2, 21.18 315.55, 125.26 -62.8, -29.15 in-in in 9.073 Saltbr-in 2.688 HRD-na-N -71.9, -46.78 72.06, -1.5 in-in-na SNCiia in-na ActLoopNT-in 2.861 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.04, 23.91 APE9-dihe-na -77.44, 160.96 APE8-dihe-na -149.27, 168.07 APE8-rot-na 78.22 APE67-dihe-na -158.56, 145.68 94.91, -2.03 APE12-dist-na 9.558 APE11-dist-na 13.567 APE10-dist-na 17.139 APE9-dist-na 13.019 None None None XRAY 1.75 0.154 0.178 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z5d Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5EA Q8TF76 471 798 798.0 Q8K:806 Type1 Active DFGin 5.08 12.459 BLAminus DFGAsp-rot-in -128.44, 172.31 71.81, 90.69 187.44, 7.51 -103.13, 26.31 316.73, 125.57 -64.15, -28.51 in-in in 9.143 Saltbr-in 2.729 HRD-na-N -68.18, -49.54 73.75, 2.15 in-in-na SNCiia in-na ActLoopNT-in 2.888 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.8, 21.0 APE9-dihe-na -73.94, 160.68 APE8-dihe-na -150.44, 166.42 APE8-rot-na 75.48 APE67-dihe-na -157.25, 143.6 92.62, -2.15 APE12-dist-na 9.572 APE11-dist-na 13.485 APE10-dist-na 17.146 APE9-dist-na 12.936 None None None XRAY 1.5 0.159 0.183 A 357 328 0 0 0 0 [[484, 797]] 1.0 6z5e Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7AVQA Q8TF76 471 798 798.0 S1Z:801 Type1 Active DFGin 5.149 12.146 BLAminus DFGAsp-rot-in -126.06, 173.12 69.03, 91.95 189.42, 3.8 -102.42, 24.12 320.3, 125.97 -52.79, -41.95 in-in in 8.998 Saltbr-in 2.659 HRD-na-N -75.14, -46.38 71.99, 2.8 in-in-na SNCiia in-na ActLoopNT-in 2.891 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.18, 22.84 APE9-dihe-na -73.32, 160.09 APE8-dihe-na -148.12, 160.7 APE8-rot-na 195.64 APE67-dihe-na -157.46, 142.25 95.7, -0.72 APE12-dist-na 9.574 APE11-dist-na 13.487 APE10-dist-na 17.118 APE9-dist-na 12.952 None None None XRAY 1.65 0.16 0.179 A 357 328 0 0 0 0 [[484, 797]] 1.0 7avq Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7OPSA Q8TF76 471 798 798.0 07C:801 Type1 Active DFGin 4.955 12.409 BLAminus DFGAsp-rot-in -120.84, 168.72 74.52, 94.25 185.82, 11.38 -110.46, 32.79 314.75, 129.03 -72.39, -27.54 in-in in 9.209 Saltbr-in 2.891 HRD-na-N -67.82, -53.79 76.87, 1.09 in-in-na SNCiia in-na ActLoopNT-in 2.935 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.38, 10.26 APE9-dihe-na -73.55, 156.67 APE8-dihe-na -147.73, 179.58 APE8-rot-na 67.78 APE67-dihe-na -167.67, 141.52 97.91, 1.48 APE12-dist-na 9.463 APE11-dist-na 13.499 APE10-dist-na 16.964 APE9-dist-na 13.035 None None None XRAY 2.38 0.179 0.229 A 357 328 0 0 0 0 [[484, 797]] 1.0 7ops Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 8RDKA Q8TF76 471 798 798.0 YQT:803 Type1 Active DFGin 5.304 12.291 BLAminus DFGAsp-rot-in -126.79, 170.58 68.55, 97.1 186.08, 1.43 -105.65, 24.46 315.14, 130.76 -63.91, -28.61 in-in in 8.949 Saltbr-in 2.684 HRD-na-N -70.8, -52.97 75.33, 1.85 in-in-na SNCiia in-na ActLoopNT-in 2.843 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -121.88, 25.66 APE9-dihe-na -78.67, 156.59 APE8-dihe-na -150.7, 178.52 APE8-rot-na 74.04 APE67-dihe-na -162.89, 139.09 96.18, -5.83 APE12-dist-na 9.438 APE11-dist-na 13.401 APE10-dist-na 17.106 APE9-dist-na 12.963 None None None XRAY 2.0 0.199 0.233 A 357 328 0 0 0 0 [[484, 797]] 1.0 8rdk Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLBA Q8TF76 471 798 798.0 A1IDB:802 Type1 Active DFGin 5.017 12.499 BLAminus DFGAsp-rot-in -122.75, 164.93 78.09, 95.44 183.51, 10.74 -111.48, 32.7 311.33, 133.52 -69.25, -37.29 in-in in 8.846 Saltbr-in 2.663 HRD-na-N -65.06, -57.81 86.13, 3.33 in-in-na SNCiia in-na ActLoopNT-in 2.883 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -97.12, -24.47 APE9-dihe-na -48.97, 165.86 APE8-dihe-na -171.41, -171.26 APE8-rot-na 65.27 APE67-dihe-na -131.18, 150.53 102.5, -31.2 APE12-dist-na 9.656 APE11-dist-na 13.445 APE10-dist-na 16.901 APE9-dist-na 13.075 None None None XRAY 2.5 0.195 0.245 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flb Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLOA Q8TF76 466 797 798.0 A1IDC:802 Type1 Inactive DFGin 5.355 12.318 BLAminus DFGAsp-rot-in -140.34, 174.89 75.76, 76.52 186.81, 36.04 -89.13, 31.66 305.79, 159.49 -77.78, -25.85 in-out in 9.084 Saltbr-out 3.76 HRD-na-N -85.47, -46.33 68.95, 25.87 out-in-na SNCoia in-na ActLoopNT-in 2.616 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.51, 102.44 APE9-dihe-na 136.93, 133.28 APE8-dihe-na -151.7, -143.81 APE8-rot-na 72.42 APE67-dihe-na -90.21, 160.33 109.28, -71.54 APE12-dist-na 9.638 APE11-dist-na 13.586 APE10-dist-na 17.18 APE9-dist-na 14.433 None None None XRAY 2.9 0.214 0.247 A 357 332 0 0 0 0 [[484, 797]] 1.0 9flo Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLQA Q8TF76 471 798 798.0 A1IDD:806 Type1 Active DFGin 5.277 11.995 BLAminus DFGAsp-rot-in -131.52, 170.51 72.45, 91.56 190.19, 7.41 -104.74, 27.71 313.77, 132.43 -58.36, -40.16 in-in in 9.194 Saltbr-in 2.385 HRD-na-N -72.62, -50.16 74.03, 2.04 in-in-na SNCiia in-na ActLoopNT-in 2.89 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -123.97, 17.68 APE9-dihe-na -77.54, 163.56 APE8-dihe-na -154.04, 168.58 APE8-rot-na 56.93 APE67-dihe-na -156.8, 141.47 98.45, -3.96 APE12-dist-na 9.579 APE11-dist-na 13.504 APE10-dist-na 17.048 APE9-dist-na 13.042 None None None XRAY 1.85 0.176 0.202 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flq Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLRA Q8TF76 471 798 798.0 A1IDE:803 Type1 Active DFGin 5.257 11.905 BLAminus DFGAsp-rot-in -132.45, 173.37 67.71, 90.56 186.48, 4.45 -101.27, 25.05 315.0, 128.67 -53.75, -42.86 in-in in 9.406 Saltbr-in 2.535 HRD-na-N -70.9, -52.21 71.26, 4.74 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -118.29, 14.34 APE9-dihe-na -78.07, 164.28 APE8-dihe-na -157.67, 170.99 APE8-rot-na 58.59 APE67-dihe-na -164.88, 135.66 97.12, 4.81 APE12-dist-na 9.597 APE11-dist-na 13.566 APE10-dist-na 17.045 APE9-dist-na 13.109 None None None XRAY 1.91 0.173 0.209 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flr Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 7SQMA Q8TF76 453 798 798.0 A5G:801 Type1 Active DFGin 5.294 12.385 BLAminus DFGAsp-rot-in -126.59, 168.89 78.77, 90.66 180.07, 13.19 -103.22, 31.48 318.95, 126.98 -62.97, -29.65 in-in in 9.033 Saltbr-in 2.862 HRD-na-N -74.3, -49.72 73.45, 2.57 in-in-na SNCiia in-na ActLoopNT-in 2.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -117.03, 13.48 APE9-dihe-na -73.56, 163.48 APE8-dihe-na -150.66, 160.36 APE8-rot-na 211.61 APE67-dihe-na -164.54, 145.89 99.66, 4.4 APE12-dist-na 9.225 APE11-dist-na 13.189 APE10-dist-na 16.762 APE9-dist-na 12.944 None None None XRAY 1.78 0.175 0.205 A 357 346 0 0 0 0 [[484, 797]] 1.0 7sqm Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6G3AA Q8TF76 471 798 798.0 5ID:805 Type1 Inactive DFGin 4.953 12.443 BLAminus DFGAsp-rot-in -127.41, 171.94 74.51, 93.23 192.28, -29.64 -106.28, 26.81 312.44, 123.45 -60.95, -29.67 in-out in 9.904 Saltbr-out 4.42 HRD-na-N -72.27, -48.82 73.62, 1.17 out-in-na SNCoia in-na ActLoopNT-in 2.883 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.57, 14.66 APE9-dihe-na -70.85, 159.17 APE8-dihe-na -152.35, 172.74 APE8-rot-na 72.92 APE67-dihe-na -156.95, 142.2 92.44, -2.34 APE12-dist-na 9.454 APE11-dist-na 13.382 APE10-dist-na 16.931 APE9-dist-na 12.993 F605T None None XRAY 1.43 0.151 0.175 A 357 328 0 0 0 0 [[484, 797]] 1.0 6g3a Homo sapiens OTHER_HASPIN_HUMAN HASP 1.9e-225 752.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9WGWA Q8TF76 453 798 798.0 A1MBI:801 Type1 Active DFGin 5.138 12.385 BLAminus DFGAsp-rot-in -147.7705, 172.4382 70.4778, 95.7674 203.5976, 0.5146 -111.9455, 33.2101 314.8585, 135.6302 -68.9733, -26.4338 in-in in 9.192 Saltbr-in 2.955 HRD-na-N -85.9524, -56.4798 80.5641, -2.245 in-in-na SNCiia in-na ActLoopNT-in 2.988 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -116.0366, 23.0374 APE9-dihe-na -79.009, 160.4727 APE8-dihe-na -154.9969, 152.9549 APE8-rot-na 52.2748 APE67-dihe-na -158.7033, 149.5673 113.8591, -8.888 APE12-dist-na 9.43 APE11-dist-na 13.164 APE10-dist-na 16.931 APE9-dist-na 12.563 None None None XRAY 2.7 0.208 0.235 A 798 346 0 0 0 0 [[484, 797]] 1.0 9wgw Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-225 753.5 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z56A Q8TF76 470 798 798.0 Q7Q:801 Type1.5_Back Inactive DFGin 4.602 12.569 BLAminus DFGAsp-rot-in -129.58, 171.28 69.16, 102.48 183.06, 16.09 -109.85, 26.06 309.6, 123.99 -45.33, -46.61 out-out out 10.104 Saltbr-out 4.52 HRD-na-N -69.89, -50.01 74.0, -0.03 out-in-na SNCoia in-na ActLoopNT-in 2.821 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -120.86, 18.07 APE9-dihe-na -73.34, 162.1 APE8-dihe-na -143.73, 169.15 APE8-rot-na 201.43 APE67-dihe-na -162.09, 141.44 91.95, 4.24 APE12-dist-na 9.424 APE11-dist-na 13.25 APE10-dist-na 17.008 APE9-dist-na 13.071 None None None XRAY 1.9 0.178 0.221 A 357 329 0 0 0 0 [[484, 797]] 1.0 6z56 Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5BA Q8TF76 469 798 798.0 Q7Z:803 Type1.5_Back Inactive DFGin 4.548 12.709 BLAminus DFGAsp-rot-in -135.9, 170.26 70.64, 101.28 193.87, -5.45 -110.64, 25.44 308.83, 121.13 -45.93, -45.39 out-out out 10.049 Saltbr-out 4.556 HRD-na-N -70.65, -51.98 77.17, -0.49 out-in-na SNCoia in-na ActLoopNT-in 2.906 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.59, 17.24 APE9-dihe-na -73.9, 162.49 APE8-dihe-na -150.9, 168.36 APE8-rot-na 77.43 APE67-dihe-na -163.72, 140.01 97.4, -1.55 APE12-dist-na 9.36 APE11-dist-na 13.278 APE10-dist-na 16.905 APE9-dist-na 12.945 None None None XRAY 1.9 0.157 0.198 A 357 330 0 0 0 0 [[484, 797]] 1.0 6z5b Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9FLCA Q8TF76 471 798 798.0 A1IDA:801 Type1.5_Back Active DFGin 4.715 12.46 BLAminus DFGAsp-rot-in -134.34, 171.12 67.31, 104.11 186.96, -4.21 -111.35, 24.44 309.33, 129.38 -43.69, -56.59 in-in in 9.127 Saltbr-in 2.572 HRD-na-N -70.37, -50.71 74.43, 4.41 in-in-na SNCiia in-na ActLoopNT-in 2.846 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -124.8, 13.59 APE9-dihe-na -68.86, 164.74 APE8-dihe-na -159.81, 175.83 APE8-rot-na 49.95 APE67-dihe-na -162.39, 140.7 102.66, -4.36 APE12-dist-na 9.337 APE11-dist-na 13.24 APE10-dist-na 16.865 APE9-dist-na 12.997 None None None XRAY 2.18 0.166 0.197 A 357 328 0 0 0 0 [[484, 797]] 1.0 9flc Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 6Z5AA Q8TF76 465 798 798.0 Q8B:60807 Type1.5_Front Inactive DFGin 4.746 13.158 BLAminus DFGAsp-rot-in -130.52, 170.23 77.78, 97.19 195.47, -11.53 -110.55, 22.86 309.49, 126.33 -50.19, -42.61 out-out out 10.928 Saltbr-out 6.049 HRD-na-N -69.87, -51.48 73.76, 2.92 out-in-na SNCoia in-na ActLoopNT-in 2.957 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.05, 16.57 APE9-dihe-na -70.55, 162.23 APE8-dihe-na -152.03, 159.2 APE8-rot-na 218.93 APE67-dihe-na -157.88, 144.9 96.43, 3.83 APE12-dist-na 9.408 APE11-dist-na 13.313 APE10-dist-na 16.953 APE9-dist-na 12.968 None None None XRAY 1.55 0.157 0.182 A 357 334 0 0 0 0 [[484, 797]] 1.0 6z5a Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER HASPIN HASP_HUMAN 9B2TK Q8TF76 470 798 798.0 No_ligand No_ligand Inactive DFGin 10.473 16.998 None DFGAsp-rot-out -74.01, 167.84 -68.22, 151.89 61.93, -23.26 -112.4, 131.65 323.3, 85.18 -72.17, -31.47 out-out out 10.371 Saltbr-out 8.739 HRD-na-N -90.05, -46.55 60.89, 17.99 out-in-na SNCoia in-na ActLoopNT-in 2.509 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -99.75, 7.12 APE9-dihe-na -76.13, 178.32 APE8-dihe-na -157.85, 172.7 APE8-rot-na 78.9 APE67-dihe-na -161.94, 175.92 118.79, -26.14 APE12-dist-na 11.19 APE11-dist-na 13.535 APE10-dist-na 18.064 APE9-dist-na 14.027 None None None EM 2.99 999.0 999.0 K 357 329 0 0 0 0 [[484, 797]] 1.0 9b2t Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER IKBKB IKKB_HUMAN AF-O14920-K1A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.752 12.489 BLAminus DFGAsp-rot-in -126.26, 179.48 57.5, 66.07 198.61, 22.06 -76.3, 19.61 299.61, 8.49 -59.99, -32.45 in-in in 8.239 Saltbr-in 2.629 HRD-in -81.33, -51.39 65.56, 14.54 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.53, 154.84 APE9-dihe-na 116.37, 176.3 APE8-dihe-in -92.66, 124.92 APE8-rot-in 300.66 APE67-dihe-in -71.88, -14.8 -44.22, -44.73 APE12-dist-in 8.696 APE11-dist-in 11.305 APE10-dist-in 5.518 APE9-dist-in 3.404 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[15, 449]] 1.0 AF-O14920-K1 Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN AF-O14920-K3A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.582 12.343 BLAminus DFGAsp-rot-in -132.39, 175.64 61.02, 71.13 201.71, -3.05 -79.51, 18.58 302.46, 7.63 -62.8, -20.15 in-in in 8.281 Saltbr-in 2.673 HRD-in -75.95, -49.61 66.27, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.0, 159.82 APE9-dihe-na 103.19, -179.04 APE8-dihe-in -94.98, 120.71 APE8-rot-in 301.22 APE67-dihe-in -70.58, -17.32 -47.51, -36.7 APE12-dist-in 8.765 APE11-dist-in 11.122 APE10-dist-in 5.289 APE9-dist-in 3.445 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[15, 449]] 1.0 AF-O14920-K3 Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CB O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.723 12.416 BLAminus DFGAsp-rot-in -105.72, -155.63 -11.15, 130.65 190.09, -71.78 -122.44, 23.83 259.84, 47.47 -53.22, -19.06 in-in in 8.472 Saltbr-in 2.771 HRD-in -75.6, -33.93 66.41, -70.8 in-in-out SNCiio in-out ActLoopNT-in 2.875 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -41.33, 120.77 APE9-dihe-na 145.43, -135.28 APE8-dihe-in -71.19, 72.96 APE8-rot-in 313.16 APE67-dihe-out 41.01, -82.54 -50.74, -88.53 APE12-dist-in 8.168 APE11-dist-out 7.777 APE10-dist-out 11.469 APE9-dist-out 12.762 S177E,S181E None None XRAY 3.98 0.267 0.299 B 669 632 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CC O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.705 12.348 BLAminus DFGAsp-rot-in -106.09, -155.19 -11.21, 130.09 189.67, -71.68 -121.05, 26.29 258.84, 49.2 -40.6, -84.85 in-in in 8.462 Saltbr-in 2.761 HRD-in -71.79, -36.13 68.15, -71.55 in-in-out SNCiio in-out ActLoopNT-in 2.652 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -85.59, 121.05 APE9-dihe-na 114.45, 160.33 APE8-dihe-out -45.72, -30.46 APE8-rot-out 41.29 APE67-dihe-out -70.56, -0.85 47.27, 14.31 APE12-dist-in 8.111 APE11-dist-in 10.92 APE10-dist-out 8.156 APE9-dist-out 11.15 S177E,S181E None None XRAY 3.98 0.267 0.299 C 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CD O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.797 12.462 BLAminus DFGAsp-rot-in -105.23, -154.26 -12.01, 129.89 190.09, -70.47 -121.15, 31.39 257.96, 46.78 -48.12, -73.54 in-in in 8.471 Saltbr-in 2.748 HRD-in -71.85, -36.56 68.87, -68.74 in-in-out SNCiio in-out ActLoopNT-in 2.707 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.45, 136.63 APE9-dihe-na 128.45, -179.44 APE8-dihe-in -65.09, 82.14 APE8-rot-in 325.06 APE67-dihe-in -46.95, -54.94 -65.9, -0.17 APE12-dist-out 6.672 APE11-dist-in 10.406 APE10-dist-out 10.242 APE9-dist-out 11.628 S177E,S181E None None XRAY 3.98 0.267 0.299 D 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CF O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.696 12.471 BLAminus DFGAsp-rot-in -105.36, -154.55 -11.85, 129.86 189.97, -71.31 -122.15, 25.59 260.49, 46.17 -49.15, -47.61 in-in in 8.513 Saltbr-in 2.773 HRD-in -73.41, -32.98 66.19, -71.94 in-in-out SNCiio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -67.61, 80.78 APE9-dihe-na 112.37, -167.24 APE8-dihe-in -59.27, 163.67 APE8-rot-in 314.68 APE67-dihe-in -41.53, -27.23 -138.25, 21.39 APE12-dist-in 9.399 APE11-dist-in 9.604 APE10-dist-out 8.526 APE9-dist-out 13.012 S177E,S181E None None XRAY 3.98 0.267 0.299 F 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVC O14920 12 664 756.0 No_ligand No_ligand Inactive DFGin 8.096 11.319 BLAminus DFGAsp-rot-out -107.88, 165.55 59.11, 66.52 314.49, -16.8 -75.63, 95.07 269.65, 121.32 -77.03, -67.33 in-out in 8.49 Saltbr-out 6.423 HRD-in -72.03, -37.96 70.51, -11.08 out-out-out SNCooo out-out ActLoopNT-out 4.088 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 160.41 APE9-dihe-na 157.46, -124.88 APE8-dihe-in -136.31, 148.05 APE8-rot-out 62.18 APE67-dihe-out -121.08, -66.51 -95.21, 70.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.959 APE9-dist-out 9.509 S177E,S181E None None XRAY 4.16 0.259 0.299 C 671 630 13 0 0 7 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVD O14920 6 665 756.0 No_ligand No_ligand Inactive DFGin 7.863 11.936 BLAminus DFGAsp-rot-in -105.3, 164.79 60.63, 66.88 194.88, 18.54 -81.0, 63.33 264.63, 107.01 -73.78, -34.0 in-out in 9.273 Saltbr-out 4.75 HRD-in -72.17, -36.92 69.94, -10.55 out-out-out SNCooo out-out ActLoopNT-out 4.334 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niio APE10-dihe-na -141.13, 136.52 APE9-dihe-na 129.04, 163.75 APE8-dihe-in -138.59, 89.42 APE8-rot-out 174.05 APE67-dihe-out -100.49, -35.82 -139.2, 164.47 APE12-dist-none 999.0 APE11-dist-in 11.291 APE10-dist-in 6.91 APE9-dist-out 9.065 S177E,S181E None None XRAY 4.16 0.259 0.299 D 671 638 12 0 0 8 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4KIKA O14920 9 663 756.0 KSA:60800 Type1 Inactive DFGin 6.178 12.724 BLAminus DFGAsp-rot-in -127.36, 175.43 56.16, 79.78 196.27, 41.08 -104.55, 41.64 323.18, 179.99 -47.28, 146.96 in-in in 8.463 Saltbr-in 2.985 HRD-in -64.56, -53.95 76.42, -28.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.34, -25.34 APE9-dihe-na -61.49, -48.74 APE8-dihe-out -60.84, -33.61 APE8-rot-out 70.5 APE67-dihe-in -55.1, -27.97 -77.97, -16.15 APE12-dist-out 22.378 APE11-dist-out 21.154 APE10-dist-out 23.562 APE9-dist-out 12.504 None SEP257 SEP257 XRAY 2.83 0.186 0.236 A 677 619 17 0 0 10 [[15, 449]] 1.0 4kik Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.2e-50 180.0 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4KIKB O14920 2 663 756.0 KSA:60700 Type1 Active DFGin 5.884 12.152 BLAminus DFGAsp-rot-in -125.87, 177.92 56.45, 91.03 199.0, 44.1 -106.12, 30.12 279.95, 121.49 -75.67, -15.82 in-in in 8.434 Saltbr-in 3.023 HRD-in -64.36, -54.26 72.29, -3.36 in-in-in SNCiii in-in ActLoopNT-in 3.074 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.33, 150.83 APE9-dihe-na 128.58, -160.18 APE8-dihe-in -124.05, 125.13 APE8-rot-in 284.23 APE67-dihe-in -62.44, -27.05 -45.7, -44.8 APE12-dist-in 7.899 APE11-dist-in 11.049 APE10-dist-in 5.068 APE9-dist-in 3.456 None SEP177,SEP181 SEP177,SEP181 XRAY 2.83 0.186 0.236 B 677 649 3 0 0 3 [[15, 449]] 1.0 4kik Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.2e-50 180.0 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVB O14920 8 664 756.0 No_ligand No_ligand Inactive DFGin 7.618 11.282 BLBminus DFGAsp-rot-out -108.54, 168.08 59.13, 68.65 311.73, -16.12 -71.93, 172.37 306.75, 9.62 -115.69, -132.64 in-out in 9.685 Saltbr-out 3.937 HRD-in -72.28, -37.94 70.43, -9.98 out-out-out SNCooo out-out ActLoopNT-out 5.592 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -5.22 APE9-dihe-na -138.83, -131.22 APE8-dihe-in -157.95, 113.56 APE8-rot-in 300.65 APE67-dihe-out -99.01, -1.05 179.64, 158.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.143 APE9-dist-out 9.763 S177E,S181E None None XRAY 4.16 0.259 0.299 B 671 641 16 0 0 9 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.929 12.514 None DFGAsp-rot-in -102.89, -152.86 -13.03, 129.81 189.48, -71.05 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.498 Saltbr-in 2.737 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.891 APE11-dist-in 11.383 APE10-dist-out 9.709 APE9-dist-out 11.52 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.95 12.284 None DFGAsp-rot-in -103.98, -153.14 -13.07, 129.81 189.13, -72.06 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.492 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.879 APE11-dist-in 9.547 APE10-dist-out 9.116 APE9-dist-out 10.795 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669 624 4 0 0 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.536 10.902 None DFGAsp-rot-in -105.5, 166.4 59.46, 69.27 196.57, 16.99 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.168 Saltbr-out 4.713 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.551 APE11-dist-in 11.201 APE10-dist-in 7.793 APE9-dist-out 7.897 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671 566 10 0 0 3 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKB IKKB_HUMAN 8OMVA O14920 8 666 756.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -106.7, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.657 Saltbr-in 3.526 HRD-in -71.9, -36.83 70.31, -11.77 in-out-out SNCioo out-out ActLoopNT-out 4.062 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.13 APE8-dihe-out -137.8, 28.35 APE8-rot-in 324.42 APE67-dihe-in -67.65, -38.83 -135.68, -11.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.005 S177E,S181E None None XRAY 4.16 0.259 0.299 A 671 636 19 0 0 13 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
OTHER IKBKE IKKE_HUMAN AF-Q14164-K1A Q14164 1 312 716.0 No_ligand No_ligand Active DFGin 6.719 13.674 BLAminus DFGAsp-rot-in -143.72, 178.6 61.91, 66.59 193.87, 23.67 -79.37, 20.21 292.68, 88.79 -65.67, -20.94 in-in in 8.405 Saltbr-in 2.618 HRD-in -84.99, -48.65 65.45, 13.11 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 165.5 APE9-dihe-na 117.63, -179.67 APE8-dihe-in -111.9, 132.86 APE8-rot-in 300.02 APE67-dihe-in -68.11, -26.98 -47.69, -41.16 APE12-dist-in 8.642 APE11-dist-in 10.257 APE10-dist-in 4.67 APE9-dist-in 3.36 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 256]] 1.0 AF-Q14164-K1 Homo sapiens OTHER_IKBKE_HUMAN STE 1e-42 152.4 1 218 218 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Inhibitor of nuclear factor kappa-B kinase subunit epsilon
OTHER IKBKE IKKE_HUMAN AF-Q14164-K3A Q14164 1 312 716.0 No_ligand No_ligand Active DFGin 6.547 14.109 BLAminus DFGAsp-rot-in -144.68, 175.81 61.0, 56.02 199.55, 13.66 -70.82, 14.62 292.13, 89.05 -61.78, -25.15 in-in in 8.199 Saltbr-in 2.672 HRD-in -79.5, -42.13 66.9, 7.05 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.76, 157.28 APE9-dihe-na 154.51, 174.08 APE8-dihe-in -85.01, 119.62 APE8-rot-in 307.91 APE67-dihe-in -71.75, -18.82 -50.25, -42.28 APE12-dist-in 8.759 APE11-dist-in 10.579 APE10-dist-in 7.187 APE9-dist-in 4.879 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[9, 256]] 1.0 AF-Q14164-K3 Homo sapiens OTHER_IKBKE_HUMAN STE 1e-42 152.4 1 218 218 156 157 158 160 162 38 55 59 132 134 133 135 203 183 178 177 176 175 174 173 172 87 Inhibitor of nuclear factor kappa-B kinase subunit epsilon
OTHER MLKL MLKL_HUMAN 6O5ZA Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus DFGAsp-rot-none -137.01, -155.47 64.86, 62.95 999.0, 999.0 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUA Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus DFGAsp-rot-none -132.65, -169.61 81.08, 16.1 999.0, 999.0 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JXUB Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus DFGAsp-rot-none -140.29, -170.33 85.23, 13.17 999.0, 999.0 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7MONA Q8NB16 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus DFGAsp-rot-none -145.54, -169.15 78.1, 22.67 999.0, 999.0 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4MWIA Q8NB16 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus DFGAsp-rot-none -145.19, 176.51 81.47, 24.62 999.0, 999.0 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi Homo sapiens OTHER_MLKL_HUMAN TKL 1.4e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6BWKA Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus DFGAsp-rot-none -134.48, -157.9 71.65, 72.71 999.0, 999.0 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk Homo sapiens OTHER_MLKL_HUMAN TKL 7.9e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 7JW7A Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus DFGAsp-rot-none -135.55, -168.18 79.35, 51.65 999.0, 999.0 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 8SLZA Q8NB16 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus DFGAsp-rot-none -150.61, -167.39 68.99, 34.67 999.0, 999.0 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 4M67A Q8NB16 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus DFGAsp-rot-none -139.33, 178.33 78.86, 30.59 999.0, 999.0 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 Homo sapiens OTHER_MLKL_HUMAN TKL 1.4e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK6A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus DFGAsp-rot-none -140.9, -170.14 65.42, 43.61 999.0, 999.0 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 Homo sapiens OTHER_MLKL_HUMAN TKL 2.8e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6LK5A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus DFGAsp-rot-none -141.79, -176.2 75.53, 28.55 999.0, 999.0 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 Homo sapiens OTHER_MLKL_HUMAN TKL 4.1e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KO1A Q8NB16 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus DFGAsp-rot-none -140.42, -174.32 76.63, 35.3 999.0, 999.0 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 Homo sapiens OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 6O5ZB Q8NB16 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None DFGAsp-rot-none -138.35, -166.14 -159.95, 69.78 999.0, 999.0 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJA Q8NB16 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-none -135.25, 171.18 -163.91, 150.5 999.0, 999.0 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MLKL MLKL_HUMAN 5KNJB Q8NB16 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None DFGAsp-rot-none -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.4e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
OTHER MOS MOS_HUMAN AF-P00540-K1A P00540 52 346 346.0 No_ligand No_ligand Active DFGin 8.378 13.7 BLAminus DFGAsp-rot-in -142.02, 174.07 61.45, 67.1 199.62, 13.23 -80.49, 18.05 298.48, 89.77 -64.82, -14.32 in-in in 7.371 Saltbr-in 2.647 HRD-in -71.69, -43.77 65.35, -14.48 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -70.96, -177.81 APE9-dihe-na 96.18, 177.01 APE8-dihe-in -87.72, 117.81 APE8-rot-in 304.89 APE67-dihe-in -67.87, -17.37 -54.41, -40.47 APE12-dist-in 10.944 APE11-dist-in 8.043 APE10-dist-in 5.298 APE9-dist-in 4.026 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[52, 345]] 1.0 AF-P00540-K1 Homo sapiens OTHER_MOS_HUMAN MOS 3.9e-169 567.5 1 292 292 218 219 220 222 224 87 106 110 198 200 199 201 261 249 244 243 242 241 240 239 238 140 Proto-oncogene serine/threonine-protein kinase mos
OTHER MOS MOS_HUMAN AF-P00540-K3A P00540 52 346 346.0 No_ligand No_ligand Active DFGin 9.264 13.809 BLAminus DFGAsp-rot-in -141.82, 174.52 57.26, 70.6 201.41, -23.51 -81.54, 16.13 289.96, 91.49 -66.55, -6.03 in-in in 7.005 Saltbr-in 2.652 HRD-in -85.36, -42.85 63.56, -7.38 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.35, 179.73 APE9-dihe-na 92.72, 163.94 APE8-dihe-in -92.75, 119.29 APE8-rot-in 309.64 APE67-dihe-in -73.52, -19.3 -59.74, -28.49 APE12-dist-in 7.746 APE11-dist-in 8.714 APE10-dist-in 5.828 APE9-dist-in 4.524 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[52, 345]] 1.0 AF-P00540-K3 Homo sapiens OTHER_MOS_HUMAN MOS 3.9e-169 567.5 1 292 292 218 219 220 222 224 87 106 110 198 200 199 201 261 249 244 243 242 241 240 239 238 140 Proto-oncogene serine/threonine-protein kinase mos
OTHER PAN3 PAN3_HUMAN 9QTUA Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 7.629 12.618 BLBminus DFGAsp-rot-na -129.14, 168.31 55.8, 57.39 311.17, 999.0 -86.82, 126.91 289.05, 999.0 84.49, -7.45 out-na out 16.938 Saltbr-na 999.0 HRD-in -70.23, -48.45 52.51, 26.26 na-out-na SNCaoa out-na ActLoopNT-out 6.726 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -59.17, 133.94 APE9-dihe-na -139.77, 155.63 APE8-dihe-na -106.23, 3.84 APE8-rot-na 207.6 APE67-dihe-na -83.45, 50.15 -63.24, -21.41 APE12-dist-na 5.615 APE11-dist-na 8.587 APE10-dist-na 9.043 APE9-dist-na 15.452 None None None EM 4.6 999.0 999.0 A 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu Homo sapiens OTHER_PAN3_HUMAN PAN3 3.6e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_HUMAN 9QTUB Q58A45 470 887 887.0 No_ligand No_ligand Pseudo DFGin 8.263 12.02 BLBminus DFGAsp-rot-na -100.76, 176.11 56.23, 61.14 294.62, 999.0 -97.32, 152.4 308.88, 999.0 53.22, 50.35 out-na out 16.294 Saltbr-na 999.0 HRD-in -72.51, -40.23 43.56, 28.97 na-out-na SNCaoa out-na ActLoopNT-out 7.368 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -88.38, 114.43 APE9-dihe-na -132.3, 150.78 APE8-dihe-na -89.72, 17.82 APE8-rot-na 302.92 APE67-dihe-na -83.3, 51.22 -62.52, -39.08 APE12-dist-na 5.216 APE11-dist-na 8.336 APE10-dist-na 9.036 APE9-dist-na 16.012 None None None EM 4.6 999.0 999.0 B 863 418 0 0 0 0 [[472, 759]] 1.0 9qtu Homo sapiens OTHER_PAN3_HUMAN PAN3 3.6e-175 587.1 1 288 288 657 658 659 661 663 521 536 540 637 639 638 640 686 676 671 670 669 668 667 666 665 570 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PBK TOPK_HUMAN AF-Q96KB5-K1A Q96KB5 24 322 322.0 No_ligand No_ligand Active DFGin 5.994 13.327 BLAminus DFGAsp-rot-in -130.77, 175.32 61.95, 66.54 207.3, -5.2 -79.12, 21.11 301.93, 999.0 -68.13, -16.97 in-in in 7.701 Saltbr-in 2.77 HRD-in -66.38, -50.09 86.37, -1.71 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -80.87, -59.74 APE9-dihe-na 54.35, -173.14 APE8-dihe-in -118.19, 132.59 APE8-rot-in 302.93 APE67-dihe-in -61.14, -23.31 -48.42, -50.72 APE12-dist-in 9.251 APE11-dist-in 8.938 APE10-dist-in 5.681 APE9-dist-in 3.201 None None None AF2 -1.0 1.0 1.0 A 299 299 0 0 0 0 [[32, 320]] 1.0 AF-Q96KB5-K1 Homo sapiens OTHER_PBK_HUMAN TKL 9e-42 149.4 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN AF-Q96KB5-K3A Q96KB5 24 322 322.0 No_ligand No_ligand Active DFGin 5.983 13.276 BLAminus DFGAsp-rot-in -134.86, 175.35 64.16, 62.22 210.94, -23.46 -75.68, 21.4 299.34, 999.0 -72.93, -12.09 in-in in 7.744 Saltbr-in 2.821 HRD-in -68.53, -48.41 78.67, 9.77 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.76, -63.28 APE9-dihe-na 49.29, -168.42 APE8-dihe-in -120.47, 133.05 APE8-rot-in 307.14 APE67-dihe-in -58.71, -21.68 -53.0, -49.72 APE12-dist-in 9.506 APE11-dist-in 8.934 APE10-dist-in 5.491 APE9-dist-in 3.16 None None None AF2 -1.0 1.0 1.0 A 299 299 0 0 0 0 [[32, 320]] 1.0 AF-Q96KB5-K3 Homo sapiens OTHER_PBK_HUMAN TKL 9e-42 149.4 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN 5J0AA Q96KB5 23 320 322.0 No_ligand No_ligand Inactive DFGin 6.807 27.493 BLBtrans DFGAsp-rot-in -120.83, 178.23 63.13, 46.26 200.31, 13.54 -77.68, 127.34 174.11, 999.0 -94.63, -173.86 out-out out 23.497 Saltbr-out 22.245 HRD-in -63.25, -61.27 89.24, -1.01 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -135.7, -53.99 APE9-dihe-na 50.9, -150.82 APE8-dihe-in -122.3, 115.82 APE8-rot-in 307.93 APE67-dihe-in -53.08, -19.22 -17.72, -67.97 APE12-dist-in 12.627 APE11-dist-in 12.569 APE10-dist-out 13.098 APE9-dist-in 3.036 T198E None None XRAY 2.74 0.222 0.271 A 300 298 0 0 0 0 [[32, 320]] 1.0 5j0a Homo sapiens OTHER_PBK_HUMAN TKL 7.5e-42 149.6 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PBK TOPK_HUMAN 5J0AB Q96KB5 19 319 322.0 No_ligand No_ligand Inactive DFGin 6.882 26.843 BLBtrans DFGAsp-rot-in -128.2, 177.09 70.09, 37.25 205.22, 9.55 -75.07, 133.1 177.1, 999.0 -120.74, -176.84 out-out out 22.717 Saltbr-out 18.531 HRD-in -62.17, -46.14 110.68, -48.17 out-in-out SNCoio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -119.14, -51.77 APE9-dihe-na 53.77, -148.64 APE8-dihe-in -130.26, 121.96 APE8-rot-in 308.15 APE67-dihe-in -51.55, -28.41 -28.76, -64.16 APE12-dist-in 12.051 APE11-dist-in 12.632 APE10-dist-out 13.05 APE9-dist-in 3.443 T198E None None XRAY 2.74 0.222 0.271 B 304 301 0 0 0 0 [[32, 320]] 1.0 5j0a Homo sapiens OTHER_PBK_HUMAN TKL 7.5e-42 149.6 5 266 262 185 186 187 189 191 64 85 89 164 166 165 167 229 216 211 210 209 208 207 206 205 116 Lymphokine-activated killer T-cell-originated protein kinase
OTHER PDIK1L PDK1L_HUMAN AF-Q8N165-K1A Q8N165 1 339 341.0 No_ligand No_ligand Active DFGin 6.585 13.907 BLAminus DFGAsp-rot-in -137.15, -178.57 58.36, 73.02 201.32, 22.95 -84.69, 18.59 288.0, 79.49 -61.61, -32.71 in-in in 8.057 Saltbr-in 2.751 HRD-in -74.27, -44.77 67.87, -15.12 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.61, 163.48 APE9-dihe-na 97.44, -168.3 APE8-dihe-in -104.85, 120.14 APE8-rot-in 307.72 APE67-dihe-in -65.45, -11.27 -42.85, -46.29 APE12-dist-in 10.931 APE11-dist-in 12.119 APE10-dist-in 6.635 APE9-dist-in 3.759 None None None AF2 -1.0 1.0 1.0 A 339 339 0 0 0 0 [[8, 329]] 1.0 AF-Q8N165-K1 Homo sapiens OTHER_PDIK1L_HUMAN OTHER 1.2e-45 162.0 1 254 254 189 190 191 193 195 37 53 57 161 163 162 164 239 228 223 222 221 220 219 218 217 120 Serine/threonine-protein kinase PDIK1L
OTHER PDIK1L PDK1L_HUMAN AF-Q8N165-K3A Q8N165 1 339 341.0 No_ligand No_ligand Active DFGin 6.498 13.847 BLAminus DFGAsp-rot-in -136.9, -174.95 57.07, 73.45 201.59, -5.32 -87.15, 14.58 289.02, 83.44 -59.4, -33.05 in-in in 8.091 Saltbr-in 2.717 HRD-in -75.79, -43.26 65.3, -15.24 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.14, 156.01 APE9-dihe-na 121.66, -171.47 APE8-dihe-in -103.05, 121.32 APE8-rot-in 306.28 APE67-dihe-in -61.81, -14.08 -46.48, -45.91 APE12-dist-in 10.511 APE11-dist-in 11.781 APE10-dist-in 6.228 APE9-dist-in 3.632 None None None AF2 -1.0 1.0 1.0 A 339 339 0 0 0 0 [[8, 329]] 1.0 AF-Q8N165-K3 Homo sapiens OTHER_PDIK1L_HUMAN OTHER 1.2e-45 162.0 1 254 254 189 190 191 193 195 37 53 57 161 163 162 164 239 228 223 222 221 220 219 218 217 120 Serine/threonine-protein kinase PDIK1L
OTHER PEAK1 PEAK1_HUMAN 6BHCA Q9H792 1285 1743 1746.0 No_ligand No_ligand Pseudo DFGin 5.695 15.242 BLAminus DFGAsp-rot-in -137.03, -177.55 61.13, 81.47 190.91, 7.71 -100.07, 34.54 288.4, 76.8 -70.97, -28.29 out-na out 10.366 Saltbr-na 999.0 HRD-in -68.45, -48.56 69.76, 5.84 na-in-out SNCaio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -102.07 APE8-dihe-out -85.98, -28.63 APE8-rot-na 192.98 APE67-dihe-in -67.0, -16.19 -77.03, -7.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.508 S1542T None None XRAY 2.3 0.196 0.234 A 438 370 43 0 0 9 [[1319, 1673]] 1.0 6bhc Homo sapiens OTHER_PEAK1_HUMAN PEAK 6.9e-47 571.2 1 94 322 1554 1555 1556 1558 1560 1359 1374 1378 1513 1515 1514 1516 1591 1580 1575 1574 1573 1572 1571 1570 1569 1464 Inactive tyrosine-protein kinase PEAK1
OTHER PIK3R4 A0JP11_HUMAN 9ZPDA A0JP11 40 1358 1358.0 No_ligand No_ligand Inactive DFGin 9.265 17.176 BLAminus DFGAsp-rot-out -124.24, 174.99 57.1, 61.91 297.05, -14.18 -69.29, 103.7 281.98, 74.95 -75.47, 98.95 out-out out 18.527 Saltbr-out 19.256 HRD-in -57.18, -53.38 88.68, -41.24 out-out-out SNCooo out-out ActLoopNT-out 9.016 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 63.11, 23.69 APE9-dihe-na -79.47, -6.7 APE8-dihe-out 76.63, 7.41 APE8-rot-na 300.76 APE67-dihe-out -128.97, 125.13 -77.5, 130.76 APE12-dist-out 15.103 APE11-dist-out 18.863 APE10-dist-out 21.599 APE9-dist-out 16.99 None None None EM 3.38 999.0 999.0 A 1445 1081 66 0 0 0 [[19, 321]] 1.0 9zpd Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHFA Q99570 14 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.316 15.926 BLBminus DFGAsp-rot-out -137.15, 164.9 65.91, 49.84 300.55, -22.02 -57.2, 122.9 277.63, 71.86 -84.62, 59.4 out-out out 18.109 Saltbr-out 17.236 HRD-out -96.05, 90.63 -67.78, 11.21 out-out-out SNCooo out-out ActLoopNT-out 9.113 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 62.11, 44.99 APE9-dihe-na -103.33, -9.73 APE8-dihe-out 66.79, 8.06 APE8-rot-na 292.08 APE67-dihe-out -138.42, 103.87 -64.74, 143.63 APE12-dist-out 14.437 APE11-dist-out 18.408 APE10-dist-out 20.977 APE9-dist-out 15.949 None None None EM 2.73 999.0 999.0 A 1409 1179 27 0 0 0 [[19, 321]] 1.0 9mhf Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHGA Q99570 2 1358 1358.0 No_ligand No_ligand Pseudo DFGin 9.585 16.209 BLBminus DFGAsp-rot-out -138.69, 173.76 59.25, 52.03 300.11, -26.18 -58.14, 130.77 283.01, 77.56 -95.81, 48.2 out-out out 18.272 Saltbr-out 21.234 HRD-in -80.12, -61.33 90.81, -7.5 out-out-out SNCooo out-out ActLoopNT-out 9.246 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.37, 16.6 APE9-dihe-na -78.09, -5.34 APE8-dihe-out 69.83, -1.25 APE8-rot-na 218.72 APE67-dihe-out -116.55, 112.58 -66.54, 126.46 APE12-dist-out 14.093 APE11-dist-out 17.864 APE10-dist-out 20.978 APE9-dist-out 15.65 None None None EM 3.2 999.0 999.0 A 1409 1188 19 0 0 0 [[19, 321]] 1.0 9mhg Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 A0JP11_HUMAN 9ZPCA A0JP11 40 1358 1358.0 No_ligand No_ligand Inactive DFGin 9.774 16.571 BLBminus DFGAsp-rot-out -113.94, 147.12 53.86, 67.39 295.31, -29.91 -62.47, 111.94 290.25, 74.02 -107.23, 90.61 out-out out 18.294 Saltbr-out 19.413 HRD-in -74.98, -56.01 94.56, -17.32 out-out-out SNCooo out-out ActLoopNT-out 7.956 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 54.86, 32.29 APE9-dihe-na -85.18, -9.13 APE8-dihe-out 61.67, 20.06 APE8-rot-na 306.61 APE67-dihe-out -98.06, 128.02 -89.14, 104.18 APE12-dist-out 15.162 APE11-dist-out 19.538 APE10-dist-out 21.509 APE9-dist-out 15.793 None None None EM 3.83 999.0 999.0 A 1445 1045 66 0 0 0 [[19, 321]] 1.0 9zpc Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.9e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9C82A Q99570 64 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -164.16, -177.07 55.57, 42.13 999.0, 999.0 -52.45, 120.86 999.0, 999.0 -77.68, 59.73 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.24, -54.58 79.91, -42.88 none-out-out SNCnoo out-out ActLoopNT-out 8.339 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 78.23, -5.89 APE9-dihe-na -85.52, -1.85 APE8-dihe-out 57.79, 25.3 APE8-rot-none 999.0 APE67-dihe-out -115.98, 93.47 -52.79, 127.92 APE12-dist-out 15.521 APE11-dist-out 19.431 APE10-dist-out 22.667 APE9-dist-out 16.035 None None None EM 6.84 999.0 999.0 A 1358 1038 84 0 0 0 [[19, 321]] 1.0 9c82 Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 7BL1CCC Q99570 12 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -76.88, 121.2 -97.88, -157.84 999.0, 999.0 -133.25, 23.54 999.0, 999.0 -119.58, 76.53 out-none out 19.336 Saltbr-none 999.0 HRD-out -62.71, 162.59 74.35, 11.28 none-out-out SNCnoo out-out ActLoopNT-out 17.743 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na -137.26, 20.08 APE9-dihe-na -166.34, -173.1 APE8-dihe-out -69.07, -7.2 APE8-rot-none 999.0 APE67-dihe-out -53.52, 153.93 -148.29, -158.16 APE12-dist-out 15.718 APE11-dist-out 15.611 APE10-dist-out 15.777 APE9-dist-out 18.72 None None None EM 9.8 0.157 999.0 CCC 1371 1189 0 0 0 0 [[19, 321]] 1.0 7bl1 Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.1e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PIK3R4 PI3R4_HUMAN 9MHHA Q99570 16 1358 1358.0 No_ligand No_ligand Pseudo None 999.0 999.0 None DFGAsp-rot-none -128.48, 178.68 62.02, 54.05 999.0, 999.0 -67.58, 106.95 999.0, 999.0 -108.31, 61.96 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.85, -55.76 81.49, -5.71 none-out-out SNCnoo out-out ActLoopNT-out 9.548 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oooo APE10-dihe-na 57.34, 14.48 APE9-dihe-na -81.14, -9.46 APE8-dihe-out 59.93, 19.07 APE8-rot-none 999.0 APE67-dihe-out -125.77, 107.65 -89.25, 132.69 APE12-dist-out 15.001 APE11-dist-out 17.495 APE10-dist-out 20.139 APE9-dist-out 15.78 None None None EM 4.5 999.0 999.0 A 1409 1191 19 0 0 0 [[19, 321]] 1.0 9mhh Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 6.4e-151 507.8 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER PINK1 PINK1_HUMAN AF-Q9BXM7-K1A Q9BXM7 148 517 581.0 No_ligand No_ligand Active DFGin 9.586 14.505 BLAminus DFGAsp-rot-in -131.4, 170.11 65.48, 83.36 206.89, -32.07 -88.4, 10.85 283.16, 73.62 -63.31, -10.14 in-in in 7.718 Saltbr-in 2.772 HRD-in -71.34, -44.54 62.36, 0.39 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 122.93, -179.32 APE9-dihe-na -97.17, -38.44 APE8-dihe-in -93.22, 94.3 APE8-rot-na 193.02 APE67-dihe-in -74.22, -40.38 -58.35, -35.37 APE12-dist-in 7.595 APE11-dist-in 9.87 APE10-dist-in 5.376 APE9-dist-in 4.101 None None None AF2 -1.0 1.0 1.0 A 370 370 0 0 0 0 [[149, 517]] 1.0 AF-Q9BXM7-K1 Homo sapiens OTHER_PINK1_HUMAN PINK1 2.6e-180 604.9 1 371 371 383 384 385 387 389 219 240 244 359 361 360 362 435 417 412 411 410 409 408 407 406 319 Serine/threonine-protein kinase PINK1, mitochondrial
OTHER PINK1 PINK1_HUMAN AF-Q9BXM7-K3A Q9BXM7 148 517 581.0 No_ligand No_ligand Active DFGin 9.682 14.874 BLAminus DFGAsp-rot-in -134.69, 177.63 63.96, 67.72 203.69, 19.82 -78.67, 7.51 279.74, 77.68 -57.02, -27.21 in-in in 7.761 Saltbr-in 2.727 HRD-in -71.41, -42.44 66.66, -21.06 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 67.28, 171.68 APE9-dihe-na 80.51, 178.42 APE8-dihe-in -80.68, 127.2