All / BABtrans / All

Total number of chains: 24
Active chains: 0
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter BABtrans 24 100.0% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.337 8.22 BABtrans DFGAsp-rot-none -82.53, 111.66 -97.33, 24.09 999.0, 999.0 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.064 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.708 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.736 APE11-dist-out 7.657 APE10-dist-out 13.168 APE9-dist-out 11.076 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348 334 0 0 0 0 [[11, 263]] 1.0 4ixp CAMK_MELK_HUMAN CAMK 4.1e-86 294.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
NEK NEK1 NEK1_HUMAN 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.644 5.999 BABtrans DFGAsp-rot-in -56.67, 136.95 -74.99, -38.65 199.33, 2.06 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.485 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.359 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.971 APE11-dist-out 20.733 APE10-dist-out 18.867 APE9-dist-out 10.432 T162A None None XRAY 2.1 0.216 0.248 A 350 278 6 0 0 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.552 6.103 BABtrans DFGAsp-rot-out -57.58, 134.02 -75.98, -33.46 49.16, -42.5 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.732 Saltbr-out 12.877 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.352 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.877 APE11-dist-out 20.629 APE10-dist-out 18.814 APE9-dist-out 10.411 T162A None None XRAY 2.1 0.216 0.248 B 350 279 5 0 0 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.305 6.08 BABtrans DFGAsp-rot-out -64.94, 139.98 -87.18, -44.3 53.04, -37.7 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.54 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.151 APE11-dist-out 20.776 APE10-dist-out 18.774 APE9-dist-out 10.678 T162A None None XRAY 1.9 0.196 0.222 A 350 278 6 0 0 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.148 BABtrans DFGAsp-rot-out -65.92, 139.98 -87.45, -46.22 51.7, -37.83 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.665 Saltbr-out 11.609 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.136 APE11-dist-out 20.69 APE10-dist-out 18.673 APE9-dist-out 10.702 T162A None None XRAY 1.9 0.196 0.222 B 350 279 5 0 0 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans DFGAsp-rot-out -91.39, 129.8 -141.56, 7.65 76.17, -45.04 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans DFGAsp-rot-out -97.55, 126.7 -140.68, 10.18 80.97, -70.46 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
TYR ABL1 ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans DFGAsp-rot-out -66.93, 131.45 -122.59, 21.38 47.1, 10.78 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-na 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans DFGAsp-rot-out -65.38, 135.53 -123.74, 24.69 47.69, 9.78 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-na 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans DFGAsp-rot-out -71.04, 121.63 -84.68, 7.52 349.51, 69.76 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-na 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.882 8.167 BABtrans DFGAsp-rot-out -93.57, 121.18 -103.19, -9.04 59.74, -50.02 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.559 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.029 APE11-dist-na 7.549 APE10-dist-na 12.042 APE9-dist-na 5.186 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268 257 4 0 0 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.708 8.272 BABtrans DFGAsp-rot-out -92.79, 121.27 -96.68, -12.13 57.64, -61.14 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.803 Saltbr-out 8.097 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.946 APE11-dist-na 7.447 APE10-dist-na 11.944 APE9-dist-na 5.19 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268 255 6 0 0 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans DFGAsp-rot-out -95.61, 121.24 -113.83, -1.35 62.76, 11.54 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-na 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99A P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 10.504 7.133 BABtrans DFGAsp-rot-out -92.78, 130.3 -132.82, 14.07 63.72, 6.85 -70.86, 131.07 175.95, 70.63 64.29, 18.34 out-out out 11.691 Saltbr-out 8.531 HRD-out -100.62, 121.88 -82.1, -7.03 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.26, 112.05 APE9-dihe-in -95.39, 166.08 APE8-dihe-in -53.58, 127.81 APE8-rot-na 330.45 APE67-dihe-in -65.74, -5.97 -74.9, -17.09 APE12-dist-na 9.895 APE11-dist-na 7.345 APE10-dist-na 11.897 APE9-dist-na 5.44 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 A 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99B P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 9.251 7.233 BABtrans DFGAsp-rot-out -90.14, 131.24 -131.91, 13.25 64.23, 7.13 -71.54, 128.59 176.43, 70.05 63.87, 19.15 out-out out 10.23 Saltbr-out 9.251 HRD-out -99.74, 124.37 -81.83, -9.5 out-in-in SNCoii in-in ActLoopNT-in 3.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.48, 114.54 APE9-dihe-in -91.05, 166.61 APE8-dihe-in -52.06, 126.92 APE8-rot-na 330.29 APE67-dihe-in -65.72, -7.18 -74.8, -16.87 APE12-dist-na 10.048 APE11-dist-na 7.696 APE10-dist-na 11.898 APE9-dist-na 5.161 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 B 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.347 8.304 BABtrans DFGAsp-rot-out -99.77, 139.1 -95.47, 13.14 59.38, -9.07 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.578 Saltbr-out 9.255 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.228 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.495 None None None XRAY 2.64 0.268 0.326 A 265 230 33 0 0 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.433 8.075 BABtrans DFGAsp-rot-out -80.9, 137.65 -92.66, -0.21 64.02, -9.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.387 Saltbr-out 9.674 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.656 None None None XRAY 2.64 0.268 0.326 B 265 234 29 0 0 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.789 BABtrans DFGAsp-rot-out -86.32, 131.84 -104.1, 6.91 55.99, 40.31 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.714 Saltbr-out 13.168 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.711 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.249 APE11-dist-na 16.172 APE10-dist-na 13.526 APE9-dist-na 6.316 None None None XRAY 1.4 0.167 0.187 A 269 264 0 0 0 0 [[402, 653]] 1.0 7yc9 TYR_BTK_HUMAN TYR 6.1e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.551 8.047 BABtrans DFGAsp-rot-out -83.49, 139.01 -103.95, 15.92 57.03, 7.8 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.745 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.38 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.71 V555R None None XRAY 1.95 0.199 0.251 A 265 244 19 0 0 14 [[402, 653]] 1.0 3oct TYR_BTK_HUMAN TYR 2.4e-93 318.2 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans DFGAsp-rot-out -99.17, 153.06 -105.84, -7.01 67.94, 21.41 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans DFGAsp-rot-out -85.22, 126.66 -111.4, 38.55 50.12, -35.74 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx TYR_SRC_HUMAN TYR 3.2e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TEK TIE2_HUMAN 1FVRA Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans DFGAsp-rot-out -70.32, 127.73 -127.01, 36.72 47.31, 12.52 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-none SNCoon out-none ActLoopNT-out 5.117 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 1FVRB Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans DFGAsp-rot-out -71.55, 125.08 -125.14, 43.48 47.62, 14.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-none SNCoon out-none ActLoopNT-out 5.131 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-na 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

All / BABtrans / All

Total number of chains: 26
Active chains: 0
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter BABtrans 26 100.0% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.337 8.22 BABtrans DFGAsp-rot-none -82.53, 111.66 -97.33, 24.09 999.0, 999.0 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.064 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.708 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.736 APE11-dist-out 7.657 APE10-dist-out 13.168 APE9-dist-out 11.076 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348 334 0 0 0 0 [[11, 263]] 1.0 4ixp Homo sapiens CAMK_MELK_HUMAN CAMK 4.1e-86 294.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
NEK NEK1 NEK1_HUMAN 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.644 5.999 BABtrans DFGAsp-rot-in -56.67, 136.95 -74.99, -38.65 199.33, 2.06 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.485 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.359 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.971 APE11-dist-out 20.733 APE10-dist-out 18.867 APE9-dist-out 10.432 T162A None None XRAY 2.1 0.216 0.248 A 350 278 6 0 0 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.552 6.103 BABtrans DFGAsp-rot-out -57.58, 134.02 -75.98, -33.46 49.16, -42.5 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.732 Saltbr-out 12.877 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.352 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.877 APE11-dist-out 20.629 APE10-dist-out 18.814 APE9-dist-out 10.411 T162A None None XRAY 2.1 0.216 0.248 B 350 279 5 0 0 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.305 6.08 BABtrans DFGAsp-rot-out -64.94, 139.98 -87.18, -44.3 53.04, -37.7 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.54 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.151 APE11-dist-out 20.776 APE10-dist-out 18.774 APE9-dist-out 10.678 T162A None None XRAY 1.9 0.196 0.222 A 350 278 6 0 0 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.148 BABtrans DFGAsp-rot-out -65.92, 139.98 -87.45, -46.22 51.7, -37.83 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.665 Saltbr-out 11.609 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.136 APE11-dist-out 20.69 APE10-dist-out 18.673 APE9-dist-out 10.702 T162A None None XRAY 1.9 0.196 0.222 B 350 279 5 0 0 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans DFGAsp-rot-out -91.39, 129.8 -141.56, 7.65 76.17, -45.04 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans DFGAsp-rot-out -97.55, 126.7 -140.68, 10.18 80.97, -70.46 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
TYR ABL1 ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans DFGAsp-rot-out -66.93, 131.45 -122.59, 21.38 47.1, 10.78 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-na 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans DFGAsp-rot-out -65.38, 135.53 -123.74, 24.69 47.69, 9.78 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-na 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans DFGAsp-rot-out -71.04, 121.63 -84.68, 7.52 349.51, 69.76 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-na 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.882 8.167 BABtrans DFGAsp-rot-out -93.57, 121.18 -103.19, -9.04 59.74, -50.02 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.559 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.029 APE11-dist-na 7.549 APE10-dist-na 12.042 APE9-dist-na 5.186 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268 257 4 0 0 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.708 8.272 BABtrans DFGAsp-rot-out -92.79, 121.27 -96.68, -12.13 57.64, -61.14 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.803 Saltbr-out 8.097 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.946 APE11-dist-na 7.447 APE10-dist-na 11.944 APE9-dist-na 5.19 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268 255 6 0 0 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans DFGAsp-rot-out -95.61, 121.24 -113.83, -1.35 62.76, 11.54 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-na 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99A P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 10.504 7.133 BABtrans DFGAsp-rot-out -92.78, 130.3 -132.82, 14.07 63.72, 6.85 -70.86, 131.07 175.95, 70.63 64.29, 18.34 out-out out 11.691 Saltbr-out 8.531 HRD-out -100.62, 121.88 -82.1, -7.03 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.26, 112.05 APE9-dihe-in -95.39, 166.08 APE8-dihe-in -53.58, 127.81 APE8-rot-na 330.45 APE67-dihe-in -65.74, -5.97 -74.9, -17.09 APE12-dist-na 9.895 APE11-dist-na 7.345 APE10-dist-na 11.897 APE9-dist-na 5.44 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 A 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 Homo sapiens TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99B P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 9.251 7.233 BABtrans DFGAsp-rot-out -90.14, 131.24 -131.91, 13.25 64.23, 7.13 -71.54, 128.59 176.43, 70.05 63.87, 19.15 out-out out 10.23 Saltbr-out 9.251 HRD-out -99.74, 124.37 -81.83, -9.5 out-in-in SNCoii in-in ActLoopNT-in 3.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.48, 114.54 APE9-dihe-in -91.05, 166.61 APE8-dihe-in -52.06, 126.92 APE8-rot-na 330.29 APE67-dihe-in -65.72, -7.18 -74.8, -16.87 APE12-dist-na 10.048 APE11-dist-na 7.696 APE10-dist-na 11.898 APE9-dist-na 5.161 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 B 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 Homo sapiens TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.347 8.304 BABtrans DFGAsp-rot-out -99.77, 139.1 -95.47, 13.14 59.38, -9.07 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.578 Saltbr-out 9.255 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.228 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.495 None None None XRAY 2.64 0.268 0.326 A 265 230 33 0 0 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.433 8.075 BABtrans DFGAsp-rot-out -80.9, 137.65 -92.66, -0.21 64.02, -9.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.387 Saltbr-out 9.674 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.656 None None None XRAY 2.64 0.268 0.326 B 265 234 29 0 0 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.789 BABtrans DFGAsp-rot-out -86.32, 131.84 -104.1, 6.91 55.99, 40.31 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.714 Saltbr-out 13.168 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.711 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.249 APE11-dist-na 16.172 APE10-dist-na 13.526 APE9-dist-na 6.316 None None None XRAY 1.4 0.167 0.187 A 269 264 0 0 0 0 [[402, 653]] 1.0 7yc9 Homo sapiens TYR_BTK_HUMAN TYR 6.1e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.551 8.047 BABtrans DFGAsp-rot-out -83.49, 139.01 -103.95, 15.92 57.03, 7.8 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.745 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.38 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.71 V555R None None XRAY 1.95 0.199 0.251 A 265 244 19 0 0 14 [[402, 653]] 1.0 3oct Homo sapiens TYR_BTK_HUMAN TYR 2.4e-93 318.2 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans DFGAsp-rot-out -99.17, 153.06 -105.84, -7.01 67.94, 21.41 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg Homo sapiens TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans DFGAsp-rot-out -85.22, 126.66 -111.4, 38.55 50.12, -35.74 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx Homo sapiens TYR_SRC_HUMAN TYR 3.2e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TEK TIE2_HUMAN 1FVRA Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans DFGAsp-rot-out -70.32, 127.73 -127.01, 36.72 47.31, 12.52 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-none SNCoon out-none ActLoopNT-out 5.117 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 1FVRB Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans DFGAsp-rot-out -71.55, 125.08 -125.14, 43.48 47.62, 14.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-none SNCoon out-none ActLoopNT-out 5.131 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-na 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.738 8.477 BABtrans DFGAsp-rot-out -103.75, 162.9 -98.62, -12.56 301.91, 16.91 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.325 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.464 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279 254 14 0 0 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.509 8.472 BABtrans DFGAsp-rot-out -108.61, 149.63 -109.15, 7.92 46.16, -6.54 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.019 Saltbr-out 10.329 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-none SNCoon out-none ActLoopNT-out 5.681 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.149 APE9-dist-na 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279 255 13 0 0 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK

All / BABtrans / All

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter BABtrans 2 100.0% 8S9FB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.738 8.477 BABtrans DFGAsp-rot-out -103.75, 162.9 -98.62, -12.56 301.91, 16.91 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.325 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.464 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279 254 14 0 0 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.509 8.472 BABtrans DFGAsp-rot-out -108.61, 149.63 -109.15, 7.92 46.16, -6.54 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.019 Saltbr-out 10.329 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-none SNCoon out-none ActLoopNT-out 5.681 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.149 APE9-dist-na 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279 255 13 0 0 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK