All / All / Type3

Total number of chains: 132
Active chains: 0
Total number of genes: 19
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 85 64.4% 8OUUB
DFGout None 21 15.9% 6NSSA
DFGin BLBplus 12 9.1% 4M13A
DFGin BLBminus 8 6.1% 7RWFA
DFGin BLAminus 3 2.3% 4ZSGA
DFGin BLAplus 2 1.5% 8A2AA
None None 1 0.8% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT2 AKT2_HUMAN 8Q61A P31751 1 435 481.0 K06:60501 Type3 Inactive DFGout 18.89 8.016 BBAminus DFGAsp-rot-in -86.01, 164.11 -136.51, 53.07 188.04, 23.44 -106.57, 16.06 303.39, 155.45 -59.47, 122.51 out-out out 16.663 Saltbr-out 14.734 HRD-in -73.93, -39.6 78.27, -25.65 out-out-none SNCoon out-none ActLoopNT-out 15.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.87, 132.41 999.0, 120.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N2D None None XRAY 2.32 0.212 0.263 A 483 382 13 0 0 6 [[152, 409]] 1.0 8q61 AGC_AKT2_HUMAN AGC 5.3e-99 336.6 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
CMGC CDK2 CDK2_HUMAN 7RXOA P24941 3 298 298.0 80E:302 Type3 Inactive DFGin 9.577 15.209 BLBminus DFGAsp-rot-out -139.06, 169.7 61.6, 49.36 302.38, -34.06 -60.15, 142.75 280.94, 71.13 -90.17, 55.28 out-none out 16.257 Saltbr-none 999.0 HRD-in -84.07, -54.4 80.78, -17.71 none-out-out SNCnoo out-out ActLoopNT-out 9.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.7 APE9-dihe-na -79.88, 129.58 APE8-dihe-in -82.74, 122.09 APE8-rot-in 299.53 APE67-dihe-in -61.07, -23.59 -103.49, 0.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.234 APE9-dist-out 11.072 None None None XRAY 1.38 0.221 0.233 A 298 266 30 0 0 11 [[4, 286]] 1.0 7rxo CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S4TA P24941 3 298 298.0 88O:302 Type3 Inactive DFGin 9.489 14.93 BLBminus DFGAsp-rot-out -139.75, 172.37 54.85, 54.18 308.39, -50.01 -61.18, 140.99 279.06, 68.96 -88.85, 55.03 out-out out 16.133 Saltbr-out 17.267 HRD-in -83.62, -51.24 80.26, -20.24 out-out-out SNCooo out-out ActLoopNT-out 9.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.14, 114.43 APE9-dihe-na -104.15, 134.39 APE8-dihe-in -80.41, 117.61 APE8-rot-in 297.25 APE67-dihe-in -59.04, -28.55 -98.31, -2.72 APE12-dist-out 21.83 APE11-dist-out 15.938 APE10-dist-out 19.475 APE9-dist-out 10.954 None None None XRAY 1.91 0.176 0.218 A 298 293 3 0 0 0 [[4, 286]] 1.0 7s4t CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S7AA P24941 2 298 298.0 8FI:302 Type3 Inactive DFGin 9.329 14.863 BLBminus DFGAsp-rot-out -135.89, 169.74 57.4, 53.57 307.6, -34.28 -62.05, 140.1 280.75, 73.98 -88.85, 60.5 out-none out 16.295 Saltbr-none 999.0 HRD-in -83.29, -52.56 81.61, -18.34 none-out-out SNCnoo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 134.88 APE9-dihe-na -76.39, 137.86 APE8-dihe-in -88.45, 118.46 APE8-rot-in 298.52 APE67-dihe-in -62.81, -25.13 -99.02, 0.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.232 APE9-dist-out 11.121 None None None XRAY 1.7 0.207 0.238 A 298 278 19 0 0 6 [[4, 286]] 1.0 7s7a CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S84A P24941 1 298 298.0 8IL:301 Type3 Inactive DFGin 9.497 14.909 BLBminus DFGAsp-rot-out -138.52, 170.26 59.0, 52.71 303.85, -34.49 -61.4, 138.63 280.38, 69.16 -88.44, 57.68 out-out out 16.574 Saltbr-out 16.91 HRD-in -84.23, -49.7 77.31, -14.87 out-out-out SNCooo out-out ActLoopNT-out 9.341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 132.74 APE9-dihe-na -86.51, 133.78 APE8-dihe-in -79.23, 128.57 APE8-rot-in 299.16 APE67-dihe-in -62.27, -25.49 -106.32, 3.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.695 APE9-dist-out 10.85 None None None XRAY 2.0 0.2 0.244 A 298 282 16 0 0 6 [[4, 286]] 1.0 7s84 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S85A P24941 3 298 298.0 8IQ:303 Type3 Inactive DFGin 9.781 15.144 BLBminus DFGAsp-rot-out -134.14, 169.78 58.04, 49.92 306.0, -42.69 -58.53, 139.92 281.4, 68.84 -85.04, 54.66 out-out out 16.939 Saltbr-out 18.208 HRD-in -87.86, -51.53 80.52, -16.15 out-out-out SNCooo out-out ActLoopNT-out 9.384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 138.57 APE9-dihe-na -72.34, 136.21 APE8-dihe-in -90.62, 126.85 APE8-rot-in 294.4 APE67-dihe-in -60.51, -24.54 -104.08, -3.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.471 APE9-dist-out 10.828 None None None XRAY 1.98 0.208 0.252 A 298 281 15 0 0 6 [[4, 286]] 1.0 7s85 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus DFGAsp-rot-out -140.51, 174.83 55.24, 52.61 297.0, -30.77 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7RWFA P24941 1 298 298.0 7TW:60302 Type3 Inactive DFGin 9.475 14.851 BLBminus DFGAsp-rot-out -140.11, 174.11 55.01, 51.54 310.66, -45.1 -61.58, 141.11 278.46, 73.02 -87.62, 59.54 out-out out 16.189 Saltbr-out 17.439 HRD-in -86.88, -54.95 86.13, -18.41 out-out-out SNCooo out-out ActLoopNT-out 9.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -106.87, 114.93 APE9-dihe-na -103.6, 143.12 APE8-dihe-in -86.24, 120.37 APE8-rot-in 298.57 APE67-dihe-in -60.28, -26.78 -101.29, -1.63 APE12-dist-out 21.854 APE11-dist-out 16.026 APE10-dist-out 19.464 APE9-dist-out 10.963 None None None XRAY 1.5 0.193 0.209 A 299 298 0 0 0 0 [[4, 286]] 1.0 7rwf CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK8 CDK8_HUMAN 4F6SA P49336 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.878 7.557 BBAminus DFGAsp-rot-in -143.37, 174.31 -133.59, 95.54 194.03, -0.3 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.67 Saltbr-in 2.813 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 2.6 0.205 0.26 A 405 327 32 0 0 17 [[22, 335]] 1.0 4f6s CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CDK8 CDK8_HUMAN 4F7JA P49336 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.423 8.595 BBAminus DFGAsp-rot-in -131.55, -173.38 -148.17, 95.28 192.53, -8.04 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.724 Saltbr-in 2.664 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405 326 33 0 0 18 [[22, 335]] 1.0 4f7j CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CDK8 CDK8_HUMAN 4F70A P49336 1 359 464.0 0ST:60501 Type3 Inactive None 18.647 14.421 None DFGAsp-rot-in -123.12, -177.92 -154.05, 113.27 191.1, 13.8 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.993 Saltbr-in 3.008 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 3.0 0.204 0.239 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f70 CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC MAPK14 MK14_HUMAN 3IW8A Q16539 4 352 360.0 HIZ:361 Type3 Inactive DFGout 14.339 10.748 BBAminus DFGAsp-rot-in -128.77, 173.15 -144.49, 96.52 190.46, 7.77 -69.13, -29.38 264.26, 95.46 -57.05, 999.0 in-in in 9.584 Saltbr-in 3.184 HRD-in -68.87, -52.0 80.48, -15.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.92 APE8-dihe-out -64.98, -16.01 APE8-rot-out 58.5 APE67-dihe-in -67.61, -18.84 -96.57, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.89 C119S,C162S,A172C,F327L None None XRAY 2.0 0.22 0.298 A 360 334 15 0 0 13 [[24, 308]] 1.0 3iw8 CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFBA Q16539 4 353 360.0 Z87:361 Type3 Inactive DFGout 13.506 8.669 BBAminus DFGAsp-rot-in -137.91, -175.41 -148.69, 98.28 182.67, -5.37 -75.6, 80.49 288.48, 128.29 -32.77, 999.0 in-in in 8.869 Saltbr-in 3.302 HRD-in -68.86, -47.3 79.01, -11.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 142.13 APE8-dihe-out -63.54, -31.96 APE8-rot-in 292.75 APE67-dihe-in -68.43, -9.24 -55.41, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.763 C119S,C162S,A172C,F327L None None XRAY 2.6 0.236 0.32 A 360 333 17 0 0 13 [[24, 308]] 1.0 3lfb CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFCA Q16539 4 354 360.0 Z86:361 Type3 Inactive DFGout 15.084 10.469 BBAminus DFGAsp-rot-in -140.93, 172.03 -136.7, 104.03 194.49, 12.28 -73.11, 19.87 257.43, 81.27 31.49, 999.0 in-in in 9.185 Saltbr-in 2.914 HRD-in -68.27, -48.31 75.76, -5.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.38 APE8-dihe-out -70.67, -45.62 APE8-rot-in 307.9 APE67-dihe-in -82.24, -9.74 -64.34, 0.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.78 C119S,C162S,A172C,F327L None None XRAY 2.8 0.242 0.326 A 360 334 17 0 0 13 [[24, 308]] 1.0 3lfc CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNVA Q16539 5 352 360.0 437:355 Type3 Inactive DFGout 14.572 9.258 BBAminus DFGAsp-rot-in -142.55, -173.27 -145.34, 106.59 186.8, -17.75 -51.19, -52.47 263.96, 85.79 66.07, 29.58 in-in in 8.439 Saltbr-in 2.655 HRD-in -68.73, -54.43 79.33, -18.5 in-out-out SNCioo out-out ActLoopNT-out 15.264 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.26, 134.3 APE9-dihe-na -61.65, -19.68 APE8-dihe-out -63.7, -16.87 APE8-rot-out 57.56 APE67-dihe-in -65.56, -22.72 -113.46, -23.13 APE12-dist-out 19.824 APE11-dist-out 21.1 APE10-dist-out 15.449 APE9-dist-out 11.706 None None None XRAY 2.1 0.188 0.235 A 354 348 0 0 0 0 [[24, 308]] 1.0 3nnv CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNXA Q16539 5 352 360.0 EDD:355 Type3 Inactive DFGout 14.2 9.216 BBAminus DFGAsp-rot-in -135.6, -177.89 -139.59, 108.47 191.86, -3.62 -57.96, -45.51 273.61, 91.9 59.97, 25.47 in-in in 8.607 Saltbr-in 2.887 HRD-in -71.36, -53.19 82.69, -16.33 in-out-out SNCioo out-out ActLoopNT-out 17.237 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -88.62, 104.06 APE9-dihe-na -72.31, 123.14 APE8-dihe-out -62.65, -30.04 APE8-rot-out 108.29 APE67-dihe-in -62.69, -25.91 -61.93, -24.39 APE12-dist-none 999.0 APE11-dist-in 12.992 APE10-dist-out 12.872 APE9-dist-out 10.683 None PTR182 PTR182 XRAY 2.28 0.222 0.285 A 354 337 11 0 0 7 [[24, 308]] 1.0 3nnx CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1W82A Q16539 4 355 360.0 L10:1356 Type3 Inactive DFGout 14.069 9.174 BBAminus DFGAsp-rot-in -147.9, -178.18 -145.43, 99.06 189.84, -16.69 -49.9, -42.31 277.8, 103.87 66.12, 29.05 in-in in 8.918 Saltbr-in 2.549 HRD-in -69.25, -58.44 82.74, -19.28 in-out-out SNCioo out-out ActLoopNT-out 15.324 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.24, 132.47 APE9-dihe-na -61.88, -19.44 APE8-dihe-out -63.75, -20.33 APE8-rot-out 53.66 APE67-dihe-in -64.33, -18.99 -112.97, -18.8 APE12-dist-out 19.607 APE11-dist-out 20.963 APE10-dist-out 15.264 APE9-dist-out 11.814 None None None XRAY 2.2 0.174 0.235 A 360 352 0 0 0 0 [[24, 308]] 1.0 1w82 CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBVA Q16539 4 355 360.0 LI3:1355 Type3 Inactive DFGout 13.811 10.62 BBAminus DFGAsp-rot-in -134.67, -171.45 -143.3, 105.97 189.47, -16.87 -79.38, -25.77 282.68, 115.07 -27.13, 80.56 in-in in 9.443 Saltbr-in 2.665 HRD-in -73.41, -55.51 76.97, -15.29 in-out-out SNCioo out-out ActLoopNT-out 15.672 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.39, 133.7 APE9-dihe-na -61.21, -22.55 APE8-dihe-out -53.62, -26.32 APE8-rot-in 304.67 APE67-dihe-in -66.43, -19.77 -114.84, -13.62 APE12-dist-out 19.73 APE11-dist-out 21.028 APE10-dist-out 15.345 APE9-dist-out 11.867 None None None XRAY 2.0 0.18 0.233 A 360 352 0 0 0 0 [[24, 308]] 1.0 1wbv CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HV7A Q16539 5 352 360.0 1AU:361 Type3 Inactive DFGout 14.463 9.132 BBAminus DFGAsp-rot-in -135.81, -172.79 -148.84, 101.39 193.04, -11.97 -62.36, -41.87 280.67, 103.39 51.74, 88.53 in-in in 8.867 Saltbr-in 3.125 HRD-in -79.33, -51.9 86.38, -21.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 109.97 APE9-dihe-na -61.86, 118.1 APE8-dihe-out -35.91, -46.58 APE8-rot-in 283.34 APE67-dihe-in -67.06, -23.86 -60.08, -25.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.948 APE9-dist-out 11.13 None None None XRAY 2.4 0.208 0.279 A 360 330 18 0 0 11 [[24, 308]] 1.0 3hv7 CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2BAJA Q16539 2 353 360.0 1PP:60401 Type3 Inactive DFGout 14.417 9.252 BBAminus DFGAsp-rot-in -151.05, 178.08 -142.27, 101.23 192.02, -25.16 -49.29, -43.08 274.53, 77.37 57.96, 32.94 in-in in 8.442 Saltbr-in 2.799 HRD-in -68.1, -55.57 80.28, -12.3 in-out-out SNCioo out-out ActLoopNT-out 15.581 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -142.01, 130.0 APE9-dihe-na -85.9, 148.12 APE8-dihe-out -78.24, -30.99 APE8-rot-out 234.7 APE67-dihe-in -63.24, -22.11 -66.59, -20.46 APE12-dist-in 12.668 APE11-dist-out 17.209 APE10-dist-out 14.646 APE9-dist-out 11.597 None None None XRAY 2.25 0.221 0.303 A 365 334 15 0 0 0 [[24, 308]] 1.0 2baj CMGC_MAPK14_HUMAN CMGC 6.4e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8UA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.796 9.306 BBAminus DFGAsp-rot-in -146.29, -170.4 -144.05, 102.12 191.07, -19.03 -67.29, -15.97 286.91, 115.68 99.79, 999.0 in-in in 9.331 Saltbr-in 3.364 HRD-in -63.28, -51.7 74.53, -20.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.38 APE8-dihe-out -70.85, -30.66 APE8-rot-in 258.69 APE67-dihe-in -65.11, -25.9 -59.1, -20.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.104 F169Y None None XRAY 2.1 0.224 0.285 A 360 332 16 0 0 13 [[24, 308]] 1.0 3o8u CMGC_MAPK14_HUMAN CMGC 3.4e-84 288.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBJA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 14.513 11.366 BBAminus DFGAsp-rot-in -154.08, -178.49 -133.48, 111.98 200.89, -22.56 -61.66, -36.04 255.28, 56.42 -103.05, -92.49 in-out in 9.304 Saltbr-out 5.802 HRD-in -72.07, -52.81 76.05, -16.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.04 APE8-dihe-out -70.24, -30.65 APE8-rot-out 197.91 APE67-dihe-in -70.14, -17.15 -63.21, -16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.973 F169R None None XRAY 2.4 0.22 0.287 A 360 332 16 0 0 12 [[24, 308]] 1.0 3obj CMGC_MAPK14_HUMAN CMGC 2.1e-83 286.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFDA Q16539 4 353 360.0 Z85:361 Type3 Inactive DFGout 14.4 11.185 None DFGAsp-rot-in -141.36, 173.62 -120.67, -179.03 214.8, -33.04 -146.09, 999.0 271.75, 117.44 999.0, 999.0 in-in in 8.854 Saltbr-in 3.232 HRD-in -64.3, -44.5 70.71, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.22 APE8-dihe-out -67.22, -56.7 APE8-rot-in 307.71 APE67-dihe-in -57.89, -22.29 -55.8, -7.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.027 C119S,C162S,A172C,F327L None None XRAY 3.4 0.23 0.305 A 360 331 19 0 0 14 [[24, 308]] 1.0 3lfd CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1KV1A Q16539 5 352 360.0 BMU:391 Type3 Inactive DFGout 13.635 9.556 None DFGAsp-rot-in -159.24, -177.02 -146.07, 100.83 191.42, -13.74 -75.42, -134.45 282.12, 117.71 154.13, 999.0 in-in in 9.163 Saltbr-in 3.578 HRD-in -68.61, -47.67 58.19, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.94 APE8-dihe-out -125.34, -40.47 APE8-rot-in 276.42 APE67-dihe-in -57.32, -20.72 -62.12, -27.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.271 None None None XRAY 2.5 0.24 0.284 A 360 331 17 0 0 13 [[24, 308]] 1.0 1kv1 CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8TA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.263 10.326 None DFGAsp-rot-in -137.91, -177.55 -138.77, 94.77 187.8, -20.35 -70.74, -1.41 999.0, 999.0 121.86, 999.0 in-out in 9.427 Saltbr-out 4.27 HRD-in -65.83, -55.54 74.19, -14.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.65 APE8-dihe-out -42.15, -37.49 APE8-rot-out 44.7 APE67-dihe-in -68.78, -13.14 -104.02, 1.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.491 F169A None None XRAY 2.0 0.229 0.282 A 360 332 16 0 0 13 [[24, 308]] 1.0 3o8t CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OC1A Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 12.729 11.102 None DFGAsp-rot-in -150.55, -172.96 -134.29, 139.02 208.04, -3.99 -118.77, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.418 Saltbr-in 3.337 HRD-in -75.41, -45.78 70.08, -9.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.76 APE8-dihe-out -49.39, -49.27 APE8-rot-in 287.36 APE67-dihe-in -53.47, -28.65 -54.1, -35.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.094 F169G None None XRAY 2.59 0.229 0.303 A 360 330 18 0 0 14 [[24, 308]] 1.0 3oc1 CMGC_MAPK14_HUMAN CMGC 3.1e-83 285.5 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK7 MK07_HUMAN 4ZSLA Q13164 53 393 816.0 4QZ:401 Type3 Inactive DFGin 6.779 16.184 BLAminus DFGAsp-rot-in -126.18, -176.13 60.65, 76.15 182.77, 18.08 -96.35, 17.76 285.61, 87.05 -59.31, -35.13 out-out out 10.056 Saltbr-out 9.323 HRD-in -67.2, -48.44 68.55, -1.34 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.33, 121.79 APE9-dihe-na 66.48, -154.79 APE8-dihe-in -93.8, 123.6 APE8-rot-in 308.6 APE67-dihe-in -68.27, -17.62 -46.65, -44.93 APE12-dist-out 14.501 APE11-dist-in 11.223 APE10-dist-in 7.3 APE9-dist-in 4.219 None None None XRAY 2.25 0.179 0.219 A 341 341 0 0 0 0 [[55, 347]] 1.0 4zsl CMGC_MAPK7_HUMAN CMGC 6.1e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4ZSJA Q13164 50 393 816.0 4R0:405 Type3 Inactive DFGin 6.809 15.895 BLAminus DFGAsp-rot-in -125.1, 178.4 65.55, 77.26 186.66, 38.28 -98.13, 17.11 289.93, 82.18 -56.03, -39.7 in-out in 9.754 Saltbr-out 9.166 HRD-in -64.96, -45.98 65.93, 5.26 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.12, 119.44 APE9-dihe-na 69.21, -148.69 APE8-dihe-in -101.85, 127.02 APE8-rot-in 308.97 APE67-dihe-in -62.6, -22.74 -46.5, -52.73 APE12-dist-out 14.457 APE11-dist-in 11.232 APE10-dist-in 7.31 APE9-dist-in 4.251 None None None XRAY 2.48 0.17 0.23 A 344 344 0 0 0 0 [[55, 347]] 1.0 4zsj CMGC_MAPK7_HUMAN CMGC 6.3e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4ZSGA Q13164 47 393 816.0 4QX:406 Type3 Inactive DFGin 6.834 16.18 BLAminus DFGAsp-rot-in -127.2, -178.81 58.37, 79.93 183.69, 19.28 -94.46, 20.05 287.86, 85.24 -54.85, -40.65 in-out in 9.972 Saltbr-out 10.251 HRD-in -63.94, -52.8 75.44, -3.93 out-in-out SNCoio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.38, 122.65 APE9-dihe-na 73.61, -149.23 APE8-dihe-in -104.8, 129.27 APE8-rot-in 311.31 APE67-dihe-in -65.93, -17.21 -46.87, -50.9 APE12-dist-out 14.523 APE11-dist-in 11.192 APE10-dist-in 7.339 APE9-dist-in 4.115 None None None XRAY 1.79 0.206 0.235 A 347 347 0 0 0 0 [[55, 347]] 1.0 4zsg CMGC_MAPK7_HUMAN CMGC 6.5e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
OTHER ERN1 ERN1_HUMAN 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.93 7.257 None DFGAsp-rot-in -145.42, 154.32 -79.25, -25.27 169.85, 66.54 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.782 None None None XRAY 2.463 0.238 0.283 A 405 381 22 0 0 17 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.04 7.266 None DFGAsp-rot-in -150.4, 164.44 -74.79, -40.79 159.24, 51.75 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.359 Saltbr-out 7.616 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405 375 24 0 0 19 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.11 None DFGAsp-rot-out -135.14, 175.91 -93.49, -10.88 55.66, -53.54 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.749 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405 378 25 0 0 18 [[571, 832]] 1.0 4yz9 OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
STE MAP2K1 MP2K1_HUMAN 7MFDB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.404 15.002 BLBplus DFGAsp-rot-in -158.62, 167.12 60.92, 63.61 183.7, 3.0 -97.12, -175.46 63.42, 90.2 -85.78, 95.16 out-out out 16.323 Saltbr-out 15.726 HRD-in -63.97, -52.79 67.43, -4.72 out-out-out SNCooo out-out ActLoopNT-out 9.676 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -74.44, -63.74 APE9-dihe-na 63.29, 177.26 APE8-dihe-out -134.0, -13.26 APE8-rot-out 186.3 APE67-dihe-out -128.3, 117.83 -113.33, 134.88 APE12-dist-out 15.876 APE11-dist-out 14.211 APE10-dist-out 20.349 APE9-dist-out 12.751 None None None EM 3.66 999.0 999.0 B 393 293 39 0 0 0 [[68, 361]] 1.0 7mfd STE_MAP2K1_HUMAN STE 2.5e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O2ZB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.693 14.557 BLBplus DFGAsp-rot-out -161.53, 165.82 61.62, 61.08 322.28, -30.7 -96.61, -171.26 43.54, 100.17 -85.43, 98.09 out-out out 16.596 Saltbr-out 16.461 HRD-in -72.32, -46.17 67.98, -6.22 out-out-out SNCooo out-out ActLoopNT-out 9.647 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -91.74, -52.46 APE9-dihe-na 52.82, -171.67 APE8-dihe-out -137.35, -7.44 APE8-rot-out 199.8 APE67-dihe-out -140.63, 115.25 -121.25, 136.62 APE12-dist-out 16.396 APE11-dist-out 14.248 APE10-dist-out 20.354 APE9-dist-out 13.12 None None None EM 3.83 999.0 999.0 B 393 293 39 0 0 0 [[68, 361]] 1.0 9o2z STE_MAP2K1_HUMAN STE 2.5e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.813 13.768 BLBplus DFGAsp-rot-in -157.46, 170.37 59.28, 64.98 193.79, -2.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.431 Saltbr-out 17.41 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.208 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.696 APE11-dist-out 18.126 APE10-dist-out 22.852 APE9-dist-out 12.424 S218A,S222A None None EM 4.36 999.0 999.0 B 394 278 51 0 0 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.188 15.038 BLBplus DFGAsp-rot-out -161.59, 167.64 63.71, 27.36 291.69, -29.13 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.613 Saltbr-out 18.798 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.797 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.162 APE11-dist-out 16.676 APE10-dist-out 21.374 APE9-dist-out 12.272 S218A,S222A None None EM 4.36 999.0 999.0 D 394 275 50 0 0 0 [[68, 361]] 1.0 9axa STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.979 13.857 BLBplus DFGAsp-rot-out -156.34, 159.86 58.05, 51.28 302.77, -6.22 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.525 Saltbr-out 16.483 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.445 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.732 APE11-dist-out 18.062 APE10-dist-out 22.927 APE9-dist-out 12.623 S218A,S222A None None EM 4.16 999.0 999.0 B 394 278 51 0 0 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.944 14.943 BLBplus DFGAsp-rot-out -155.71, -173.77 60.85, 40.35 292.65, -28.69 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.882 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.375 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.774 APE11-dist-out 17.062 APE10-dist-out 21.141 APE9-dist-out 12.44 S218A,S222A None None EM 4.16 999.0 999.0 D 394 275 50 0 0 0 [[68, 361]] 1.0 9axc STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UD Q02750 31 380 393.0 CHU:401 Type3 Inactive DFGin 6.258 14.245 BLBplus DFGAsp-rot-out -155.2, 170.07 62.24, 48.49 290.44, -9.58 -103.46, 163.38 44.86, 81.23 -80.64, 82.9 out-out out 15.804 Saltbr-out 15.56 HRD-in -72.61, -47.48 72.0, -5.51 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.99, 151.57 APE9-dihe-na -129.02, 151.01 APE8-dihe-out -101.49, -25.69 APE8-rot-in 295.14 APE67-dihe-out -149.54, 133.77 -134.81, 174.59 APE12-dist-out 17.407 APE11-dist-out 17.558 APE10-dist-out 22.648 APE9-dist-out 12.754 S218A,S222A None None XRAY 2.91 0.232 0.264 D 395 317 33 0 0 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UF Q02750 30 380 393.0 CHU:401 Type3 Inactive DFGin 6.24 14.242 BLBplus DFGAsp-rot-out -149.4, 162.55 67.26, 47.9 291.19, -5.21 -103.2, 163.92 46.52, 88.85 -79.29, 85.22 out-out out 15.539 Saltbr-out 16.236 HRD-in -74.73, -46.69 72.92, -6.37 out-out-out SNCooo out-out ActLoopNT-out 9.834 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -124.83, 125.43 APE9-dihe-na -156.49, 116.77 APE8-dihe-out -98.23, -8.63 APE8-rot-in 320.21 APE67-dihe-out -147.81, 133.84 -133.15, 172.65 APE12-dist-out 18.664 APE11-dist-out 16.786 APE10-dist-out 21.173 APE9-dist-out 12.537 S218A,S222A None None XRAY 2.91 0.232 0.264 F 395 322 29 0 0 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK1 PAK1_HUMAN 4ZJIA Q13153 254 542 545.0 4OQ:601 Type3 Inactive DFGout 14.486 7.862 BBAminus DFGAsp-rot-in -124.98, 172.53 -139.37, 60.86 176.3, 32.23 -76.04, -0.31 290.5, 165.49 -101.27, 2.8 out-out out 11.456 Saltbr-out 9.179 HRD-in -74.01, -52.86 71.92, 1.18 out-out-out SNCooo out-out ActLoopNT-out 4.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.27, 143.67 APE9-dihe-na 128.32, -164.34 APE8-dihe-in -119.07, 120.68 APE8-rot-in 308.34 APE67-dihe-in -57.07, -27.71 -45.34, -50.35 APE12-dist-in 12.553 APE11-dist-in 13.876 APE10-dist-out 8.621 APE9-dist-in 3.47 None None None XRAY 1.99 0.192 0.22 A 299 278 11 0 0 6 [[270, 521]] 1.0 4zji STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIB Q13153 254 540 545.0 4OQ:601 Type3 Inactive DFGout 14.347 7.911 BBAminus DFGAsp-rot-in -122.99, 169.12 -135.22, 63.32 177.32, 36.71 -78.42, -1.05 289.36, 166.77 -102.4, 3.7 out-out out 11.355 Saltbr-out 9.5 HRD-in -73.68, -52.57 71.67, 0.82 out-out-out SNCooo out-out ActLoopNT-out 4.463 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.49, 143.59 APE9-dihe-na 127.1, -165.24 APE8-dihe-in -117.4, 119.62 APE8-rot-in 306.54 APE67-dihe-in -58.04, -25.35 -40.93, -53.52 APE12-dist-in 12.464 APE11-dist-in 13.856 APE10-dist-out 8.632 APE9-dist-in 3.458 None None None XRAY 1.99 0.192 0.22 B 299 276 11 0 0 6 [[270, 521]] 1.0 4zji STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIC Q13153 250 541 545.0 4OQ:601 Type3 Inactive DFGout 14.215 7.811 BBAminus DFGAsp-rot-in -121.31, 171.98 -130.54, 60.34 181.05, 40.62 -81.43, -2.47 290.92, 169.61 -101.24, 4.12 out-out out 11.332 Saltbr-out 7.131 HRD-in -69.29, -53.03 70.55, 2.57 out-out-out SNCooo out-out ActLoopNT-out 4.697 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.35, 146.99 APE9-dihe-na -60.27, 135.04 APE8-dihe-in -113.96, 115.83 APE8-rot-in 300.08 APE67-dihe-in -103.44, 21.24 -64.25, -21.29 APE12-dist-out 15.886 APE11-dist-out 15.167 APE10-dist-out 10.107 APE9-dist-out 8.616 None None None XRAY 1.99 0.192 0.22 C 299 281 11 0 0 5 [[270, 521]] 1.0 4zji STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJID Q13153 253 541 545.0 4OQ:601 Type3 Inactive DFGout 14.159 7.854 BBAminus DFGAsp-rot-in -123.8, 172.68 -134.23, 62.09 175.61, 36.84 -78.43, -2.16 289.23, 167.94 -100.19, 2.82 out-out out 11.24 Saltbr-out 7.121 HRD-in -70.67, -52.48 69.45, 4.83 out-in-out SNCoio in-out ActLoopNT-in 3.118 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.08, 151.63 APE9-dihe-na -63.3, 137.02 APE8-dihe-in -115.16, 115.5 APE8-rot-in 303.37 APE67-dihe-in -103.69, 23.11 -64.43, -20.74 APE12-dist-out 15.883 APE11-dist-out 15.53 APE10-dist-out 10.143 APE9-dist-out 8.504 None None None XRAY 1.99 0.192 0.22 D 299 280 9 0 0 4 [[270, 521]] 1.0 4zji STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJA Q13153 249 539 545.0 4OR:601 Type3 Inactive DFGout 14.93 7.884 BBAminus DFGAsp-rot-in -121.34, 171.37 -136.52, 66.59 177.56, 28.21 -79.2, -3.71 291.13, 159.73 -99.9, 1.22 out-out out 12.071 Saltbr-out 9.378 HRD-in -72.7, -51.01 69.62, -1.62 out-out-out SNCooo out-out ActLoopNT-out 4.327 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -108.73, 140.93 APE9-dihe-na 129.99, -160.2 APE8-dihe-in -123.0, 117.69 APE8-rot-in 310.93 APE67-dihe-in -52.25, -30.59 -37.79, -59.06 APE12-dist-in 12.193 APE11-dist-in 13.862 APE10-dist-out 8.608 APE9-dist-in 3.296 None None None XRAY 2.2 0.203 0.238 A 299 280 11 0 0 7 [[270, 521]] 1.0 4zjj STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJB Q13153 251 539 545.0 4OR:601 Type3 Inactive DFGout 14.948 7.932 BBAminus DFGAsp-rot-in -119.95, 170.64 -136.17, 65.87 175.85, 40.96 -79.78, -2.78 291.31, 160.73 -99.76, -0.39 out-out out 12.019 Saltbr-out 9.348 HRD-in -71.08, -50.26 68.41, 0.81 out-out-out SNCooo out-out ActLoopNT-out 4.306 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -110.29, 139.33 APE9-dihe-na 127.62, -164.58 APE8-dihe-in -118.42, 122.35 APE8-rot-in 307.66 APE67-dihe-in -57.94, -28.38 -41.45, -53.66 APE12-dist-in 13.115 APE11-dist-in 13.841 APE10-dist-out 8.56 APE9-dist-in 3.322 None None None XRAY 2.2 0.203 0.238 B 299 277 12 0 0 7 [[270, 521]] 1.0 4zjj STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJC Q13153 251 542 545.0 4OR:601 Type3 Inactive DFGout 14.688 7.965 BBAminus DFGAsp-rot-in -117.77, 169.13 -137.11, 67.47 180.55, 26.2 -83.74, 26.97 291.43, 162.22 -146.25, 999.0 out-none out 11.922 Saltbr-none 999.0 HRD-in -69.95, -52.05 69.27, 1.3 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -119.64, 146.88 APE9-dihe-na -53.72, 136.85 APE8-dihe-in -114.06, 116.5 APE8-rot-in 303.53 APE67-dihe-in -106.18, 21.65 -68.59, -18.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.339 None None None XRAY 2.2 0.203 0.238 C 299 276 16 0 0 7 [[270, 521]] 1.0 4zjj STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJD Q13153 252 541 545.0 4OR:601 Type3 Inactive DFGout 13.746 8.374 BBAminus DFGAsp-rot-in -122.31, 164.62 -155.38, 60.52 184.47, 33.47 -68.67, -25.53 302.03, 128.76 -82.18, -4.05 out-none out 11.407 Saltbr-none 999.0 HRD-in -69.6, -54.19 71.18, 0.18 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -124.0, 135.82 APE9-dihe-na -50.29, 114.73 APE8-dihe-in -106.44, 108.75 APE8-rot-in 304.37 APE67-dihe-in -111.14, 19.03 -62.05, -15.3 APE12-dist-out 16.261 APE11-dist-out 16.538 APE10-dist-out 10.957 APE9-dist-out 8.242 None None None XRAY 2.2 0.203 0.238 D 299 274 13 0 0 4 [[270, 521]] 1.0 4zjj STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZLOA Q13153 250 543 545.0 4PV:601 Type3 Inactive DFGout 12.793 7.554 None DFGAsp-rot-in -124.62, -179.06 -146.97, -83.67 211.45, -6.5 75.06, -28.03 305.7, 127.25 125.56, 999.0 out-out out 10.827 Saltbr-out 5.775 HRD-in -62.03, -53.17 80.12, -16.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -89.92, 112.03 APE9-dihe-na 92.48, 159.15 APE8-dihe-in -79.66, 123.09 APE8-rot-out 71.08 APE67-dihe-out -53.9, -30.99 -83.68, 58.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.202 None TPO423 TPO423 XRAY 2.5 0.196 0.222 A 297 278 16 0 0 9 [[270, 521]] 1.0 4zlo STE_PAK1_HUMAN STE 2.1e-95 325.0 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
TKL LIMK1 LIMK1_HUMAN 7ATUA P53667 330 634 647.0 RXN:60701 Type3 Inactive DFGout 14.988 10.001 BBAminus DFGAsp-rot-in -109.21, 174.28 -142.39, 83.58 164.18, 11.1 -74.29, -18.32 285.18, 140.01 -111.7, 18.04 out-out out 16.084 Saltbr-out 15.451 HRD-in -57.8, -51.16 74.51, -19.19 out-out-out SNCooo out-out ActLoopNT-out 4.329 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -67.49, -72.98 APE9-dihe-na -69.77, -144.94 APE8-dihe-in -75.87, 154.24 APE8-rot-na 319.69 APE67-dihe-in -61.11, -47.04 -83.72, 16.19 APE12-dist-in 12.865 APE11-dist-in 10.208 APE10-dist-out 8.797 APE9-dist-out 10.305 None None None XRAY 2.8 0.244 0.316 A 310 275 26 0 0 21 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUB P53667 330 636 647.0 RXN:60701 Type3 Inactive DFGout 14.871 10.385 BBAminus DFGAsp-rot-in -106.42, 171.63 -143.53, 69.8 166.47, 38.77 -63.76, -14.73 294.73, 133.01 -108.57, -0.53 out-out out 15.698 Saltbr-out 15.929 HRD-in -85.21, -51.0 77.42, -16.83 out-out-out SNCooo out-out ActLoopNT-out 4.354 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -53.4, -74.11 APE9-dihe-na -79.86, -149.85 APE8-dihe-in -70.91, 144.09 APE8-rot-na 286.44 APE67-dihe-in -64.41, -40.03 -82.97, 20.25 APE12-dist-in 12.959 APE11-dist-in 10.358 APE10-dist-out 8.533 APE9-dist-out 10.077 None None None XRAY 2.8 0.244 0.316 B 310 286 21 0 0 20 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUC P53667 350 632 647.0 RXN:60701 Type3 Inactive DFGout 14.718 10.033 BBAminus DFGAsp-rot-in -88.15, 177.18 -140.99, 72.99 167.73, 87.1 -70.21, -9.41 281.23, 139.59 -112.2, 13.51 out-none out 16.334 Saltbr-none 999.0 HRD-in -66.72, -54.87 73.93, -4.49 none-out-none SNCnon out-none ActLoopNT-out 4.173 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.36 APE8-rot-na 315.64 APE67-dihe-in -46.43, -53.49 -85.62, 16.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.244 0.316 C 310 244 50 0 0 26 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUD P53667 354 632 647.0 RXN:60701 Type3 Inactive DFGout 15.331 10.224 BBAminus DFGAsp-rot-in -128.0, -173.91 -147.27, 77.77 191.36, 11.05 -61.68, -36.22 282.23, 139.99 -104.61, 32.02 out-none out 15.918 Saltbr-none 999.0 HRD-in -81.48, -48.99 75.04, -24.96 none-out-out SNCnoo out-out ActLoopNT-out 4.359 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 90.29 APE8-dihe-in -64.34, 138.15 APE8-rot-none 999.0 APE67-dihe-in -66.61, -40.13 -99.55, 33.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.651 None None None XRAY 2.8 0.244 0.316 D 310 243 50 0 0 25 [[339, 606]] 1.0 7atu TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK2 LIMK2_HUMAN 4TPTA P53671 330 631 638.0 35H:701 Type3 Inactive DFGout 16.096 11.142 BBAminus DFGAsp-rot-in -114.59, 179.84 -146.01, 83.03 175.52, 22.11 -70.78, -31.53 290.09, 109.97 -82.43, -2.78 out-out out 15.862 Saltbr-out 16.376 HRD-in -70.45, -54.99 74.1, -7.22 out-out-out SNCooo out-out ActLoopNT-out 4.568 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -135.17, 156.48 APE9-dihe-na 121.28, -168.66 APE8-dihe-in -107.67, 124.96 APE8-rot-na 184.54 APE67-dihe-in -64.31, -24.66 -54.17, -26.81 APE12-dist-in 12.014 APE11-dist-out 14.643 APE10-dist-out 8.775 APE9-dist-in 3.89 None None None XRAY 2.6 0.223 0.274 A 303 279 23 0 0 23 [[331, 603]] 1.0 4tpt TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 4TPTB P53671 330 632 638.0 35H:701 Type3 Inactive DFGout 16.355 11.034 BBAminus DFGAsp-rot-in -130.75, -177.01 -149.57, 73.72 182.67, 23.33 -61.92, -29.69 288.54, 113.54 -95.75, 7.29 out-out out 15.844 Saltbr-out 15.526 HRD-in -72.14, -56.53 86.02, -32.37 out-out-out SNCooo out-out ActLoopNT-out 4.602 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -134.67, 147.66 APE9-dihe-na 124.79, 175.82 APE8-dihe-in -86.47, 130.25 APE8-rot-na 184.44 APE67-dihe-in -70.78, -18.97 -49.94, -29.41 APE12-dist-in 12.536 APE11-dist-out 14.694 APE10-dist-out 8.83 APE9-dist-in 4.468 None None None XRAY 2.6 0.223 0.274 B 303 277 26 0 0 26 [[331, 603]] 1.0 4tpt TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 5NXDB P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 15.929 9.622 BBAminus DFGAsp-rot-in -120.85, -179.43 -146.81, 73.71 187.77, 6.08 -62.47, -25.15 278.45, 45.25 -102.04, 2.18 out-out out 15.912 Saltbr-out 15.763 HRD-in -73.52, -53.98 77.3, -13.62 out-out-none SNCoon out-none ActLoopNT-out 4.503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.09, -26.34 999.0, 50.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 B 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd TKL_LIMK2_HUMAN TKL 7.2e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 5NXDA P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 18.215 8.199 None DFGAsp-rot-in -133.95, 177.46 -146.72, 77.25 180.57, 19.03 -55.91, -32.79 190.69, 79.33 -96.52, 3.25 out-out out 16.007 Saltbr-out 14.828 HRD-in -75.21, -55.71 76.14, -4.58 out-out-none SNCoon out-none ActLoopNT-out 4.382 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.14, -25.71 999.0, -20.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 A 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd TKL_LIMK2_HUMAN TKL 7.2e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL RIPK1 RIPK1_HUMAN 9MZYA Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.417 8.594 BBAminus DFGAsp-rot-in -121.56, 163.73 -131.53, 69.41 181.05, 25.67 -69.13, -26.9 298.04, 169.8 -86.04, 2.22 out-out out 14.107 Saltbr-out 12.369 HRD-in -64.46, -51.93 74.85, -2.94 out-out-out SNCooo out-out ActLoopNT-out 5.757 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.39 APE8-dihe-out -63.39, -46.19 APE8-rot-out 52.35 APE67-dihe-in -66.56, -26.22 -73.65, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.629 None None None XRAY 2.32 0.242 0.315 A 287 266 21 0 0 11 [[17, 287]] 1.0 9mzy TKL_RIPK1_HUMAN TKL 1.2e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZYB Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.256 8.174 BBAminus DFGAsp-rot-in -120.1, 168.45 -128.87, 68.39 181.49, 22.28 -67.18, -24.35 298.87, 170.09 -81.57, -2.83 out-out out 13.682 Saltbr-out 12.765 HRD-in -64.72, -49.57 76.17, -4.64 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.1 APE8-dihe-out -64.67, -43.51 APE8-rot-in 298.41 APE67-dihe-in -63.01, -29.76 -69.62, -21.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.549 None None None XRAY 2.32 0.242 0.315 B 287 276 11 0 0 7 [[17, 287]] 1.0 9mzy TKL_RIPK1_HUMAN TKL 1.2e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZZB Q13546 7 294 671.0 A1BU5:301 Type3 Inactive DFGout 12.91 8.093 BBAminus DFGAsp-rot-in -123.12, 159.01 -125.1, 65.1 192.29, -20.92 -71.49, -24.77 295.21, 165.65 -63.79, -21.88 out-out out 13.71 Saltbr-out 11.064 HRD-in -62.15, -53.84 85.81, -19.41 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.81 APE8-dihe-out -60.77, -43.31 APE8-rot-out 60.81 APE67-dihe-in -60.82, -28.84 -40.61, -46.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.68 0.229 0.272 B 288 273 15 0 0 11 [[17, 287]] 1.0 9mzz TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZXA Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.155 8.608 BBAminus DFGAsp-rot-in -120.41, 164.67 -130.16, 69.77 182.71, 26.46 -71.17, -32.11 302.55, 177.42 -76.49, -1.63 out-out out 13.684 Saltbr-out 12.721 HRD-in -65.64, -50.76 75.88, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.89 APE8-dihe-in -83.2, 116.64 APE8-rot-out 186.76 APE67-dihe-in -69.05, -25.68 -94.99, 5.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.474 None None None XRAY 2.53 0.217 0.263 A 289 265 24 0 0 17 [[17, 287]] 1.0 9mzx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZXB Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.385 8.604 BBAminus DFGAsp-rot-in -119.33, 165.52 -131.66, 72.61 180.15, 28.94 -71.75, -33.33 299.78, 172.5 -85.72, 10.29 out-out out 13.591 Saltbr-out 12.641 HRD-in -65.63, -49.62 75.8, -10.44 out-out-out SNCooo out-out ActLoopNT-out 5.433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.61 APE8-dihe-in -77.58, 125.06 APE8-rot-out 189.43 APE67-dihe-in -65.68, -27.84 -90.79, 1.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.082 None None None XRAY 2.53 0.217 0.263 B 289 268 21 0 0 11 [[17, 287]] 1.0 9mzx TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C3EA Q13546 9 293 671.0 EJY:301 Type3 Inactive DFGout 13.211 8.704 BBAminus DFGAsp-rot-in -130.6, 166.87 -129.4, 74.2 188.21, 18.77 -68.21, -19.66 307.39, 166.79 -86.61, -13.09 out-out out 13.511 Saltbr-out 13.358 HRD-out -69.12, 116.26 -89.73, 2.91 out-out-out SNCooo out-out ActLoopNT-out 5.346 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -66.6 APE8-dihe-out -78.73, -34.83 APE8-rot-out 76.27 APE67-dihe-in -63.09, -35.77 -52.34, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.672 None None None XRAY 2.6 0.261 0.307 A 297 258 27 0 0 17 [[17, 287]] 1.0 6c3e TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITHA Q13546 8 294 671.0 RCM:307 Type3 Inactive DFGout 14.111 8.042 BBAminus DFGAsp-rot-in -124.73, 172.6 -138.48, 68.81 179.15, 23.28 -68.88, -22.32 295.59, 2.39 -91.07, 2.58 out-out out 13.598 Saltbr-out 12.965 HRD-in -65.52, -52.94 79.64, -21.46 out-out-out SNCooo out-out ActLoopNT-out 5.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.47 APE8-dihe-in -73.02, 143.29 APE8-rot-in 249.4 APE67-dihe-in -62.29, -27.12 -114.9, 22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.706 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 A 294 247 40 0 0 19 [[17, 287]] 1.0 4ith TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITHB Q13546 7 294 671.0 RCM:307 Type3 Inactive DFGout 13.911 7.88 BBAminus DFGAsp-rot-in -124.36, 170.84 -137.49, 67.98 177.85, 28.12 -68.97, -21.27 308.9, 171.62 -88.43, 4.67 out-out out 13.671 Saltbr-out 12.354 HRD-in -66.08, -61.08 99.79, -41.26 out-out-out SNCooo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.33 APE8-dihe-out -80.2, -0.81 APE8-rot-out 76.21 APE67-dihe-in -69.94, -29.23 -70.53, -20.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.372 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 B 294 270 18 0 0 12 [[17, 287]] 1.0 4ith TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITIA Q13546 8 294 671.0 1HW:301 Type3 Inactive DFGout 14.809 7.536 BBAminus DFGAsp-rot-in -119.39, 171.24 -131.64, 70.92 187.85, 10.43 -77.19, -1.86 301.33, 175.38 -111.16, 12.31 out-out out 14.461 Saltbr-out 12.021 HRD-in -63.67, -39.02 58.78, 3.1 out-out-out SNCooo out-out ActLoopNT-out 5.063 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 135.54 APE9-dihe-na -28.2, -40.78 APE8-dihe-out -49.5, 2.2 APE8-rot-out 126.42 APE67-dihe-in -74.62, -10.45 -88.53, -16.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.612 APE9-dist-out 11.919 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 A 294 272 15 0 0 10 [[17, 287]] 1.0 4iti TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITIB Q13546 7 294 671.0 1HW:301 Type3 Inactive DFGout 15.287 8.279 BBAminus DFGAsp-rot-in -133.02, 174.0 -136.87, 74.76 191.45, -4.85 -71.37, -1.88 298.09, 0.08 -118.72, 6.02 out-out out 14.736 Saltbr-out 12.105 HRD-in -67.98, -50.79 78.94, -25.18 out-out-out SNCooo out-out ActLoopNT-out 5.029 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.75 APE8-dihe-out -48.23, -36.55 APE8-rot-out 178.41 APE67-dihe-in -64.1, -17.64 -60.59, -39.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 B 294 270 18 0 0 11 [[17, 287]] 1.0 4iti TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NYHA Q13546 8 294 671.0 L8D:301 Type3 Inactive DFGout 13.435 9.94 BBAminus DFGAsp-rot-in -117.53, 173.88 -134.6, 59.12 180.97, 29.37 -68.75, -26.25 307.46, 178.63 -80.82, 2.01 out-out out 14.527 Saltbr-out 12.436 HRD-in -67.92, -54.26 77.85, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.11 APE8-dihe-in -70.09, 140.73 APE8-rot-out 198.89 APE67-dihe-in -52.04, -30.58 -103.66, -3.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.748 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 A 296 265 22 0 0 12 [[17, 287]] 1.0 6nyh TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NYHB Q13546 11 294 671.0 L8D:301 Type3 Inactive DFGout 13.932 9.865 BBAminus DFGAsp-rot-in -122.04, 173.92 -132.13, 59.75 185.19, 23.07 -67.23, -24.7 302.43, 2.51 -86.8, 3.14 out-out out 14.458 Saltbr-out 12.191 HRD-in -67.08, -53.83 81.99, -19.6 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -85.36 APE8-dihe-in -72.43, 144.74 APE8-rot-out 184.05 APE67-dihe-in -66.66, -21.12 -105.82, 2.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 B 296 246 38 0 0 18 [[17, 287]] 1.0 6nyh TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q31A Q13546 7 294 671.0 A1CNU:301 Type3 Inactive DFGout 13.735 8.23 BBAminus DFGAsp-rot-in -120.57, 170.34 -130.15, 58.16 181.17, 27.05 -63.68, -22.9 293.63, 177.4 -82.91, 0.44 out-out out 13.869 Saltbr-out 11.761 HRD-in -67.33, -55.79 80.06, -9.46 out-out-out SNCooo out-out ActLoopNT-out 6.088 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.72 APE8-rot-out 187.62 APE67-dihe-in -62.14, -27.07 -101.34, -1.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 A 296 269 19 0 0 12 [[17, 287]] 1.0 9q31 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32A Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.528 8.226 BBAminus DFGAsp-rot-in -121.4, 167.22 -125.99, 62.31 194.01, 28.99 -66.66, -26.07 287.26, 169.09 -79.79, -0.98 out-out out 14.14 Saltbr-out 12.229 HRD-in -66.73, -48.33 74.89, -10.1 out-out-out SNCooo out-out ActLoopNT-out 5.546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 27.12 APE8-dihe-in -71.54, 159.66 APE8-rot-out 185.13 APE67-dihe-in -62.84, -25.84 -113.42, -0.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 A 296 266 22 0 0 12 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32B Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.34 8.34 BBAminus DFGAsp-rot-in -125.85, 168.27 -125.45, 64.08 186.92, 57.88 -70.16, -25.81 289.07, 162.55 -79.65, -1.07 out-out out 14.45 Saltbr-out 13.417 HRD-in -68.2, -50.31 78.72, -10.28 out-out-out SNCooo out-out ActLoopNT-out 5.817 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.67 APE8-rot-out 168.75 APE67-dihe-in -63.25, -31.84 -91.02, 4.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 B 296 251 36 0 0 18 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32C Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.46 8.281 BBAminus DFGAsp-rot-in -120.28, 170.4 -126.9, 54.43 197.64, 68.53 -63.55, -25.46 293.16, 167.28 -77.54, -4.89 out-out out 13.586 Saltbr-out 12.769 HRD-in -69.24, -48.43 74.25, -12.6 out-out-out SNCooo out-out ActLoopNT-out 6.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.99 APE8-dihe-in -75.87, 151.54 APE8-rot-out 168.79 APE67-dihe-in -61.95, -25.0 -103.03, -0.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 C 296 259 29 0 0 17 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32D Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.457 8.195 BBAminus DFGAsp-rot-in -119.22, 172.55 -131.06, 63.91 185.62, 55.86 -69.23, -20.15 294.44, 171.06 -85.09, -1.42 out-none out 14.021 Saltbr-none 999.0 HRD-in -82.45, -48.15 73.95, -16.29 none-out-out SNCnoo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.84 APE8-dihe-in -75.4, 152.13 APE8-rot-out 189.23 APE67-dihe-in -64.73, -21.38 -109.94, 2.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.29 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 D 296 250 37 0 0 19 [[17, 287]] 1.0 9q32 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus DFGAsp-rot-in -121.61, 171.92 -133.79, 66.08 177.88, 26.12 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus DFGAsp-rot-in -118.21, 174.22 -136.13, 64.53 181.1, 28.93 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY8A Q13546 8 294 671.0 A1IX7:301 Type3 Inactive DFGout 12.981 9.596 BBAminus DFGAsp-rot-in -141.13, 164.94 -130.11, 66.18 182.31, 35.61 -66.58, -24.49 309.73, 7.18 -84.28, -2.51 out-out out 14.033 Saltbr-out 11.772 HRD-out -86.53, 114.22 -72.4, -38.91 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.03 APE8-dihe-out -67.08, -34.07 APE8-rot-out 196.53 APE67-dihe-in -68.73, -30.32 -60.21, -30.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.808 None None None XRAY 2.98 0.23 0.295 A 297 260 27 0 0 18 [[17, 287]] 1.0 9hy8 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY8B Q13546 7 294 671.0 1HX:305 Type3 Inactive DFGout 13.904 9.078 BBAminus DFGAsp-rot-in -137.15, 163.21 -126.56, 62.14 181.49, 37.0 -66.56, -24.08 304.02, 3.22 -81.88, 1.19 out-out out 13.745 Saltbr-out 12.321 HRD-out -85.29, 111.77 -72.25, -38.63 out-out-out SNCooo out-out ActLoopNT-out 6.114 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -35.46 APE8-rot-out 195.34 APE67-dihe-in -63.95, -33.12 -61.2, -31.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.98 0.23 0.295 B 297 271 17 0 0 12 [[17, 287]] 1.0 9hy8 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY9A Q13546 10 294 671.0 A1IX9:301 Type3 Inactive DFGout 12.864 9.725 BBAminus DFGAsp-rot-in -132.24, 163.44 -119.98, 69.92 175.12, 34.62 -71.64, -30.92 302.3, 2.93 -73.75, -3.09 out-out out 14.314 Saltbr-out 11.313 HRD-in -66.75, -56.07 86.01, -13.31 out-out-out SNCooo out-out ActLoopNT-out 6.04 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -51.61 APE8-dihe-out -64.18, -21.53 APE8-rot-out 61.29 APE67-dihe-in -61.96, -24.09 -103.08, -2.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.198 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 A 297 251 34 0 0 18 [[17, 287]] 1.0 9hy9 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY9B Q13546 8 294 671.0 A1IX9:301 Type3 Inactive DFGout 14.034 9.477 BBAminus DFGAsp-rot-in -133.17, 165.69 -124.95, 70.39 172.81, 33.44 -65.88, -32.58 304.79, 2.82 -81.7, 4.58 out-out out 14.395 Saltbr-out 11.494 HRD-in -67.55, -54.35 91.32, -11.86 out-out-out SNCooo out-out ActLoopNT-out 6.175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.85 APE8-dihe-in -57.79, 140.57 APE8-rot-out 188.52 APE67-dihe-in -62.67, -21.78 -100.89, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.311 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 B 297 265 22 0 0 13 [[17, 287]] 1.0 9hy9 TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DA Q13546 8 294 671.0 EJP:1100 Type3 Inactive DFGout 15.126 10.11 BBAminus DFGAsp-rot-in -117.56, 178.71 -149.43, 73.24 186.48, 32.2 -69.95, -18.38 305.75, 179.55 -101.55, 7.83 out-out out 16.257 Saltbr-out 16.566 HRD-in -55.77, -51.03 80.27, -34.22 out-out-out SNCooo out-out ActLoopNT-out 5.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.93 APE8-dihe-in -106.53, 126.83 APE8-rot-in 321.17 APE67-dihe-in -67.47, -17.91 -88.44, 5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.641 None None None XRAY 2.52 0.246 0.296 A 297 267 20 0 0 13 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DB Q13546 7 294 671.0 EJP:1100 Type3 Inactive DFGout 14.902 9.997 BBAminus DFGAsp-rot-in -109.17, 170.78 -134.96, 67.82 191.15, 62.76 -67.04, -23.45 302.04, 179.31 -86.78, -0.45 out-out out 13.971 Saltbr-out 13.274 HRD-in -58.83, -55.33 81.23, -6.46 out-out-out SNCooo out-out ActLoopNT-out 6.208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 135.34 APE8-dihe-in -76.56, 126.03 APE8-rot-in 339.29 APE67-dihe-in -57.69, -33.16 -79.19, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.114 None None None XRAY 2.52 0.246 0.296 B 297 266 22 0 0 16 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DC Q13546 10 294 671.0 EJP:1100 Type3 Inactive DFGout 13.888 9.719 BBAminus DFGAsp-rot-in -117.68, 178.27 -141.12, 66.69 187.08, 29.32 -63.91, -32.83 304.36, 1.77 -82.22, -7.01 out-out out 14.002 Saltbr-out 13.724 HRD-out -79.05, 115.27 -95.69, 8.59 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.35 APE8-dihe-in -80.27, 139.4 APE8-rot-in 352.11 APE67-dihe-in -58.83, -30.61 -90.66, -17.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.716 None None None XRAY 2.52 0.246 0.296 C 297 258 27 0 0 18 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DD Q13546 5 293 671.0 EJP:1100 Type3 Inactive DFGout 14.579 10.057 BBAminus DFGAsp-rot-in -117.58, 172.01 -139.03, 81.37 191.71, 1.36 -72.34, -39.58 302.56, 173.11 -76.31, -0.83 out-out out 15.418 Saltbr-out 15.949 HRD-out -76.11, 120.54 -93.07, -33.93 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.51 APE8-dihe-in -75.78, 153.21 APE8-rot-out 63.53 APE67-dihe-in -63.87, -30.91 -109.82, 5.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.301 None None None XRAY 2.52 0.246 0.296 D 297 266 23 0 0 16 [[17, 287]] 1.0 6c4d TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 5HX6A Q13546 10 294 671.0 65U:301 Type3 Inactive DFGout 13.746 10.081 BBAminus DFGAsp-rot-in -114.15, 174.66 -134.73, 71.48 191.79, 44.33 -75.96, -22.44 306.17, 175.84 -90.96, 8.33 out-out out 15.167 Saltbr-out 14.396 HRD-in -69.31, -54.37 72.33, -26.98 out-out-out SNCooo out-out ActLoopNT-out 5.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.42 APE8-dihe-in -113.81, 128.35 APE8-rot-in 307.51 APE67-dihe-in -68.28, -25.41 -91.99, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.926 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 A 303 259 26 0 0 18 [[17, 287]] 1.0 5hx6 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 5TX5A Q13546 10 294 671.0 7MJ:301 Type3 Inactive DFGout 13.573 10.201 BBAminus DFGAsp-rot-in -116.16, 171.57 -130.87, 63.14 191.27, 66.76 -69.82, -14.33 312.94, 168.86 -98.42, 6.27 out-out out 14.845 Saltbr-out 14.379 HRD-in -66.81, -51.24 62.33, -1.21 out-out-out SNCooo out-out ActLoopNT-out 6.13 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.73 APE8-dihe-in -110.36, 127.1 APE8-rot-in 310.57 APE67-dihe-in -70.3, -28.6 -100.12, 4.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.291 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 A 303 259 26 0 0 18 [[17, 287]] 1.0 5tx5 TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6HHOA Q13546 8 294 671.0 G4W:301 Type3 Inactive DFGout 13.67 9.694 BBAminus DFGAsp-rot-in -115.24, 164.48 -126.66, 62.71 179.85, 55.23 -63.79, -26.65 296.63, 179.45 -87.49, 3.26 out-out out 14.208 Saltbr-out 13.017 HRD-in -59.4, -57.1 78.79, -22.09 out-out-out SNCooo out-out ActLoopNT-out 6.209 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.3 APE8-dihe-in -93.04, 144.83 APE8-rot-out 195.71 APE67-dihe-in -65.11, -26.33 -104.41, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 A 303 273 14 0 0 11 [[17, 287]] 1.0 6hho TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6HHOB Q13546 7 294 671.0 G4W:301 Type3 Inactive DFGout 13.824 9.442 BBAminus DFGAsp-rot-in -119.74, 167.8 -136.07, 70.92 169.95, -84.84 -69.13, -25.22 303.5, 11.26 -79.53, -4.81 out-out out 14.318 Saltbr-out 12.609 HRD-in -55.52, -56.34 83.4, -19.29 out-out-none SNCoon out-none ActLoopNT-out 6.05 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.12 APE8-rot-in 325.58 APE67-dihe-in -55.64, -31.82 -55.9, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 B 303 266 22 0 0 12 [[17, 287]] 1.0 6hho TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6OCQB Q13546 7 294 671.0 M5J:301 Type3 Inactive DFGout 13.012 8.057 BBAminus DFGAsp-rot-in -130.11, 162.38 -122.52, 81.31 185.37, -5.83 -82.7, -15.44 293.68, 160.97 -87.37, 2.43 out-out out 13.636 Saltbr-out 13.611 HRD-in -64.49, -53.65 73.55, -4.84 out-out-out SNCooo out-out ActLoopNT-out 5.464 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-out 173.0 APE67-dihe-in -61.59, -15.49 -61.5, -24.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 B 303 274 14 0 0 12 [[17, 287]] 1.0 6ocq TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FA Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.955 9.481 BBAminus DFGAsp-rot-in -112.95, 165.41 -130.42, 63.72 180.08, 54.56 -66.93, -21.93 297.24, 0.02 -91.89, 5.73 out-out out 14.529 Saltbr-out 13.191 HRD-in -56.51, -60.39 80.9, -22.8 out-out-out SNCooo out-out ActLoopNT-out 5.924 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.38 APE8-rot-out 178.71 APE67-dihe-in -64.62, -25.33 -74.5, -6.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 A 303 252 34 0 0 16 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FB Q13546 10 294 671.0 JSW:301 Type3 Inactive DFGout 13.78 9.691 BBAminus DFGAsp-rot-in -117.91, 170.03 -135.39, 68.26 176.51, 38.79 -70.88, -17.07 303.86, 8.01 -86.89, -7.53 out-out out 14.147 Saltbr-out 14.183 HRD-in -58.11, -56.03 90.31, -47.38 out-out-out SNCooo out-out ActLoopNT-out 6.22 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.8 APE8-dihe-in -110.24, 128.64 APE8-rot-out 54.88 APE67-dihe-in -53.24, -34.36 -61.38, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.919 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 B 303 256 29 0 0 17 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FC Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.993 9.934 BBAminus DFGAsp-rot-in -129.98, 154.77 -113.58, 87.15 188.59, -5.78 -77.89, -25.03 313.32, 1.4 -85.25, 0.11 out-out out 14.529 Saltbr-out 15.039 HRD-in -68.31, -36.48 72.06, -57.73 out-out-out SNCooo out-out ActLoopNT-out 5.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.85 APE8-dihe-in -109.8, 132.44 APE8-rot-out 61.03 APE67-dihe-in -41.51, -34.43 -97.85, -8.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.153 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 C 303 253 33 0 0 16 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FD Q13546 11 294 671.0 JSW:301 Type3 Inactive DFGout 14.45 9.248 BBAminus DFGAsp-rot-in -142.39, 170.94 -125.26, 78.91 214.02, -13.58 -70.36, -35.3 283.29, 144.33 -66.46, -23.13 out-out out 15.019 Saltbr-out 16.123 HRD-in -59.61, -37.57 70.15, -52.85 out-out-out SNCooo out-out ActLoopNT-out 6.06 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.22 APE8-dihe-in -103.39, 137.53 APE8-rot-out 189.96 APE67-dihe-in -50.68, -36.72 -90.03, -10.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.433 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 D 303 250 34 0 0 17 [[17, 287]] 1.0 6r5f TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6RLNA Q13546 8 294 671.0 K8K:301 Type3 Inactive DFGout 13.828 9.344 BBAminus DFGAsp-rot-in -121.93, 164.11 -127.72, 59.44 180.68, 46.74 -57.14, -30.4 302.07, 177.27 -86.63, -0.56 out-out out 14.464 Saltbr-out 13.169 HRD-in -55.19, -50.82 78.22, -37.5 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.07 APE8-dihe-in -87.79, 130.01 APE8-rot-in 299.1 APE67-dihe-in -57.83, -39.09 -99.26, -10.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.716 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 A 303 266 21 0 0 11 [[17, 287]] 1.0 6rln TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NW2A Q13546 8 294 671.0 L4Y:301 Type3 Inactive DFGout 13.608 9.512 BBAminus DFGAsp-rot-in -126.76, 173.12 -134.47, 72.41 174.44, 34.45 -77.05, -17.16 300.87, 12.85 -87.44, 3.81 out-out out 13.794 Saltbr-out 12.048 HRD-in -68.25, -50.83 78.22, -14.78 out-out-none SNCoon out-none ActLoopNT-out 6.312 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.64 APE8-rot-in 298.28 APE67-dihe-in -63.58, -21.18 -59.6, -37.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.212 0.261 A 310 260 27 0 0 12 [[17, 287]] 1.0 6nw2 TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NW2B Q13546 11 294 671.0 L4Y:301 Type3 Inactive DFGout 13.716 9.993 BBAminus DFGAsp-rot-in -122.99, 177.91 -138.58, 64.6 180.05, 18.31 -73.14, -19.26 303.52, 11.16 -82.07, -0.78 out-out out 14.265 Saltbr-out 13.612 HRD-in -71.79, -51.87 81.67, -16.37 out-out-out SNCooo out-out ActLoopNT-out 6.279 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.93 APE8-dihe-out -77.38, -12.49 APE8-rot-out 198.5 APE67-dihe-in -68.62, -19.61 -107.28, 7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.491 None None None XRAY 2.0 0.212 0.261 B 310 246 38 0 0 18 [[17, 287]] 1.0 6nw2 TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9GTYA Q13546 8 294 671.0 RCM:301 Type3 Inactive DFGout 13.983 8.222 BBAminus DFGAsp-rot-in -123.34, 171.31 -137.95, 64.52 176.69, 29.45 -61.74, -25.38 305.36, 176.3 -90.28, 0.66 out-out out 13.752 Saltbr-out 13.245 HRD-in -64.08, -57.67 81.97, -22.12 out-out-out SNCooo out-out ActLoopNT-out 5.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -14.17 APE8-dihe-out -79.25, -21.69 APE8-rot-out 51.22 APE67-dihe-in -62.86, -31.23 -89.57, 1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.816 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 A 313 253 34 0 0 19 [[17, 287]] 1.0 9gty TKL_RIPK1_HUMAN TKL 1.6e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TYR ABL1 ABL1_HUMAN 3QRKA P00519 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.538 9.263 BBAminus DFGAsp-rot-in -128.74, -174.73 -147.03, 106.14 178.14, -8.71 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.853 Saltbr-in 2.674 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.303 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.815 APE11-dist-na 15.758 APE10-dist-na 10.991 APE9-dist-na 7.585 None None None XRAY 2.3 0.192 0.281 A 277 268 0 0 0 0 [[242, 495]] 1.0 3qrk TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR DDR1 DDR1_HUMAN 7FEHA Q08345 603 912 913.0 3UI:1001 Type3 Inactive DFGout 14.614 10.976 BBAminus DFGAsp-rot-in -140.43, -166.19 -155.59, 100.98 183.75, -8.06 -76.78, -5.55 282.16, 80.98 68.97, 34.94 in-in in 8.239 Saltbr-in 2.707 HRD-in -73.62, -47.42 78.59, -7.41 in-out-in SNCioi out-in ActLoopNT-out 18.36 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.1, 130.52 APE9-dihe-in -126.17, 127.16 APE8-dihe-in -82.15, 70.85 APE8-rot-na 34.51 APE67-dihe-in -74.2, -7.26 -55.53, -34.86 APE12-dist-na 14.424 APE11-dist-na 11.384 APE10-dist-na 6.966 APE9-dist-na 7.347 None None None XRAY 1.61 0.168 0.206 A 320 293 11 0 0 0 [[610, 907]] 1.0 7feh TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5BVKA Q08345 604 911 913.0 4VC:1007 Type3 Inactive DFGout 12.534 10.223 None DFGAsp-rot-in -129.55, -176.3 -140.67, 98.58 194.41, 10.77 -92.44, 131.08 301.57, 107.64 -55.47, -44.27 in-in in 8.231 Saltbr-in 2.779 HRD-in -71.41, -52.83 83.7, -18.63 in-out-in SNCioi out-in ActLoopNT-out 15.725 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -83.83, 116.31 APE9-dihe-in -112.39, 120.52 APE8-dihe-in -71.84, 64.33 APE8-rot-na 29.08 APE67-dihe-in -73.09, -12.57 -54.87, -32.03 APE12-dist-na 18.806 APE11-dist-na 15.611 APE10-dist-na 11.342 APE9-dist-na 7.263 None None None XRAY 2.29 0.19 0.232 A 324 278 30 0 0 0 [[610, 907]] 1.0 5bvk TYR_DDR1_HUMAN TYR 1.7e-92 315.4 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 8A27A P00533 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.672 14.381 BLAplus DFGAsp-rot-out -145.52, -178.77 57.22, 42.47 287.34, -1.9 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.238 Saltbr-out 11.714 HRD-in -70.42, -54.97 75.01, -8.44 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.484 None None None XRAY 1.07 0.126 0.16 A 326 269 16 0 0 16 [[712, 970]] 1.0 8a27 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2AA P00533 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.117 14.356 BLAplus DFGAsp-rot-out -139.34, 175.57 57.42, 45.45 286.02, -2.31 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.637 Saltbr-out 12.255 HRD-in -68.19, -54.53 72.52, -7.02 out-out-none SNCoon out-none ActLoopNT-out 6.62 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.037 None None None XRAY 1.43 0.19 0.223 A 326 306 8 0 0 8 [[712, 970]] 1.0 8a2a TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2DA P00533 701 1021 1210.0 KXY:1103 Type3 Inactive DFGin 6.285 15.539 BLBminus DFGAsp-rot-out -141.89, -177.21 45.57, 75.85 289.49, -7.72 -58.33, 149.05 294.71, 179.21 -62.78, 135.74 out-out out 13.017 Saltbr-out 10.523 HRD-in -72.83, -53.94 77.64, -5.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.3 APE8-dihe-in -76.96, 68.89 APE8-rot-na 35.24 APE67-dihe-in -71.59, -9.31 -48.88, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.169 L858R,V948R None None XRAY 1.11 0.164 0.179 A 326 281 10 0 0 10 [[712, 970]] 1.0 8a2d TYR_EGFR_HUMAN TYR 8.4e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5ZWJA P00533 702 985 1210.0 9LL:1101 Type3 Inactive DFGin 5.542 14.462 BLBplus DFGAsp-rot-out -134.76, 169.78 70.33, 21.35 292.87, -5.43 -80.26, 157.71 46.02, 86.11 85.63, 6.58 out-none out 12.365 Saltbr-none 999.0 HRD-in -62.57, -46.38 74.18, -0.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.69 APE8-dihe-in -84.81, 75.57 APE8-rot-na 34.77 APE67-dihe-in -62.54, -42.94 -62.02, -41.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.058 T790M,C797S,V948R None None XRAY 2.9 0.256 0.272 A 355 267 17 0 0 17 [[712, 970]] 1.0 5zwj TYR_EGFR_HUMAN TYR 6.1e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2BA P00533 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.426 14.435 BLBplus DFGAsp-rot-out -143.53, -174.33 44.34, 37.79 305.95, -21.04 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.246 Saltbr-out 12.26 HRD-in -75.49, -60.69 77.7, -7.21 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.066 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326 272 17 0 0 17 [[712, 970]] 1.0 8a2b TYR_EGFR_HUMAN TYR 8.4e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR ITK ITK_HUMAN 4M12A Q08881 355 618 620.0 1YZ:701 Type3 Inactive DFGin 7.901 15.256 BLBplus DFGAsp-rot-out -141.2, 169.8 60.4, 25.89 302.78, -1.84 -67.61, 137.8 36.63, 92.49 68.92, 0.26 out-out out 17.153 Saltbr-out 16.924 HRD-in -66.63, -51.27 84.1, -22.7 out-out-out SNCooo out-out ActLoopNT-out 7.86 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.29, 13.09 APE9-dihe-in -55.02, 125.4 APE8-dihe-in -69.29, 63.1 APE8-rot-na 28.21 APE67-dihe-in -55.35, -27.28 -53.96, -32.74 APE12-dist-na 16.702 APE11-dist-na 19.4 APE10-dist-na 14.954 APE9-dist-na 9.292 None None None XRAY 2.15 0.185 0.228 A 269 264 0 0 0 0 [[363, 614]] 1.0 4m12 TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4M13A Q08881 355 618 620.0 1E0:701 Type3 Inactive DFGin 7.937 15.236 BLBplus DFGAsp-rot-out -140.0, 164.92 66.92, 22.84 301.09, -7.35 -65.43, 134.74 36.83, 90.87 73.53, -6.2 out-out out 17.258 Saltbr-out 17.152 HRD-in -67.22, -57.57 90.49, -24.24 out-out-out SNCooo out-out ActLoopNT-out 7.795 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.18, 13.19 APE9-dihe-in -58.29, 129.4 APE8-dihe-in -71.46, 60.73 APE8-rot-na 27.96 APE67-dihe-in -58.06, -25.43 -56.35, -32.28 APE12-dist-na 16.675 APE11-dist-na 19.459 APE10-dist-na 14.985 APE9-dist-na 9.271 None None None XRAY 1.85 0.19 0.232 A 269 264 0 0 0 0 [[363, 614]] 1.0 4m13 TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR MERTK MERTK_HUMAN 7AW4A Q12866 576 862 999.0 S5E:901 Type3 Inactive DFGout 14.166 6.988 BBAminus DFGAsp-rot-in -151.73, 174.5 -134.58, 93.64 199.28, -45.36 -99.75, 11.14 282.83, 106.8 -60.06, 134.62 out-out out 12.678 Saltbr-out 6.924 HRD-in -71.68, -56.26 76.66, -5.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.4 APE8-rot-na 27.32 APE67-dihe-in -72.74, -3.62 -49.0, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.98 0.215 0.246 A 313 264 23 0 0 17 [[587, 856]] 1.0 7aw4 TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW4B Q12866 574 862 999.0 S5E:901 Type3 Inactive DFGout 14.17 7.002 BBAminus DFGAsp-rot-in -152.39, 174.35 -134.62, 92.94 199.68, -46.03 -100.47, 8.02 282.22, 107.21 -60.15, 130.28 out-out out 12.756 Saltbr-out 7.104 HRD-in -72.36, -56.01 76.07, -4.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.48 APE8-rot-na 27.51 APE67-dihe-in -72.81, -3.1 -48.72, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.98 0.215 0.246 B 313 257 32 0 0 18 [[587, 856]] 1.0 7aw4 TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 8OUUA P08581 1059 1346 1390.0 W49:1404 Type3 Inactive DFGout 13.515 6.876 BBAminus DFGAsp-rot-in -147.46, -168.73 -151.04, 108.81 190.89, -19.36 -112.08, 40.61 288.5, 94.51 -110.14, -161.37 out-out out 12.355 Saltbr-out 10.46 HRD-in -63.12, -55.99 76.4, -17.82 out-out-in SNCooi out-in ActLoopNT-out 9.091 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -82.11, 150.07 APE9-dihe-in -72.2, 149.25 APE8-dihe-in -80.89, 58.5 APE8-rot-na 27.43 APE67-dihe-in -74.53, -1.63 -44.12, -49.33 APE12-dist-na 999.0 APE11-dist-na 6.546 APE10-dist-na 10.792 APE9-dist-na 7.893 D1228V None None XRAY 1.77 0.203 0.225 A 309 284 4 0 0 4 [[1078, 1339]] 1.0 8ouu TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUUB P08581 1057 1346 1390.0 W49:1405 Type3 Inactive DFGout 13.488 6.97 BBAminus DFGAsp-rot-in -144.89, -171.19 -149.83, 102.26 193.02, -21.79 -101.8, 30.99 273.18, 101.18 -108.36, -152.3 out-out out 12.311 Saltbr-out 10.383 HRD-in -62.48, -51.05 73.17, -16.23 out-out-in SNCooi out-in ActLoopNT-out 9.188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -63.11, 139.96 APE9-dihe-in -71.28, 138.06 APE8-dihe-in -78.82, 59.01 APE8-rot-na 36.37 APE67-dihe-in -74.44, -3.9 -45.73, -43.18 APE12-dist-na 10.634 APE11-dist-na 6.56 APE10-dist-na 11.61 APE9-dist-na 8.235 D1228V None None XRAY 1.77 0.203 0.225 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ouu TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUVA P08581 1053 1346 1390.0 W3R:1401 Type3 Inactive DFGout 13.432 6.982 BBAminus DFGAsp-rot-in -150.55, -166.67 -153.94, 107.37 184.46, -3.47 -108.14, 42.08 281.33, 84.2 -114.79, -152.59 out-out out 12.492 Saltbr-out 10.788 HRD-in -65.45, -52.15 77.68, -39.15 out-out-in SNCooi out-in ActLoopNT-out 9.594 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.07, 137.88 APE9-dihe-in -75.04, 140.45 APE8-dihe-in -83.02, 58.2 APE8-rot-na 29.39 APE67-dihe-in -74.39, -2.19 -46.6, -48.03 APE12-dist-na 10.641 APE11-dist-na 6.116 APE10-dist-na 10.331 APE9-dist-na 8.21 D1228V None None XRAY 1.783 0.193 0.22 A 309 294 0 0 0 0 [[1078, 1339]] 1.0 8ouv TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUVB P08581 1057 1346 1390.0 W3R:1403 Type3 Inactive DFGout 13.51 7.147 BBAminus DFGAsp-rot-in -147.83, -171.85 -148.7, 102.33 190.45, -21.29 -101.0, 36.34 274.67, 80.19 -118.46, -149.43 out-out out 12.359 Saltbr-out 10.666 HRD-in -65.36, -51.5 76.95, -23.29 out-out-in SNCooi out-in ActLoopNT-out 9.126 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.24, 136.99 APE9-dihe-in -67.7, 139.76 APE8-dihe-in -82.33, 58.02 APE8-rot-na 32.55 APE67-dihe-in -77.97, -2.31 -52.96, -31.41 APE12-dist-na 10.989 APE11-dist-na 6.865 APE10-dist-na 11.983 APE9-dist-na 8.293 D1228V None None XRAY 1.783 0.193 0.22 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ouv TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OV7A P08581 1051 1346 1390.0 W3W:1401 Type3 Inactive DFGout 16.903 9.364 BBAminus DFGAsp-rot-in -153.61, -165.39 -151.4, 119.76 182.24, 19.38 -84.83, -13.59 281.18, 90.67 -96.35, -144.67 out-out out 12.327 Saltbr-out 10.74 HRD-in -65.11, -52.02 80.74, -20.69 out-out-out SNCooo out-out ActLoopNT-out 6.49 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -77.6, 93.42 APE9-dihe-in -116.32, 89.67 APE8-dihe-out -52.96, -30.95 APE8-rot-na 334.19 APE67-dihe-in -78.41, -2.44 -56.72, -27.38 APE12-dist-na 16.993 APE11-dist-na 17.033 APE10-dist-na 11.812 APE9-dist-na 10.786 D1228V None None XRAY 1.95 0.274 0.287 A 309 289 7 0 0 0 [[1078, 1339]] 1.0 8ov7 TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OVZA P08581 1061 1346 1390.0 W3N:1411 Type3 Inactive DFGout 13.353 7.006 BBAminus DFGAsp-rot-in -146.53, -171.32 -145.54, 124.96 177.55, -83.35 -119.17, 42.96 279.31, 88.35 -118.39, -154.9 out-out out 12.132 Saltbr-out 11.597 HRD-in -61.66, -54.56 76.63, -30.67 out-out-in SNCooi out-in ActLoopNT-out 9.29 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -75.2, 144.98 APE9-dihe-in -69.5, 147.31 APE8-dihe-in -82.74, 56.17 APE8-rot-na 31.37 APE67-dihe-in -67.83, -2.09 -44.04, -52.84 APE12-dist-na 10.733 APE11-dist-na 6.553 APE10-dist-na 11.677 APE9-dist-na 8.152 D1228V None None XRAY 2.206 0.227 0.275 A 309 286 0 0 0 0 [[1078, 1339]] 1.0 8ovz TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OVZB P08581 1057 1346 1390.0 W3N:1410 Type3 Inactive DFGout 13.772 6.771 BBAminus DFGAsp-rot-in -146.01, -169.05 -148.05, 116.27 204.18, -49.13 -112.98, 47.33 264.21, 88.29 -128.7, -142.69 out-out out 12.232 Saltbr-out 11.019 HRD-in -68.15, -51.01 72.21, -18.47 out-out-in SNCooi out-in ActLoopNT-out 9.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.33, 137.86 APE9-dihe-in -70.76, 127.71 APE8-dihe-in -79.23, 64.44 APE8-rot-na 29.84 APE67-dihe-in -76.38, -8.07 -54.71, -26.75 APE12-dist-na 10.89 APE11-dist-na 6.759 APE10-dist-na 11.936 APE9-dist-na 8.433 D1228V None None XRAY 2.206 0.227 0.275 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ovz TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGA P08581 1060 1344 1390.0 W40:1401 Type3 Inactive DFGout 15.215 7.185 BBAminus DFGAsp-rot-in -151.69, 176.81 -129.27, 111.57 197.85, -20.24 -101.99, 63.08 247.0, 19.93 135.49, 100.91 out-none out 12.564 Saltbr-none 999.0 HRD-in -54.29, -59.14 87.34, -18.08 none-out-none SNCnon out-none ActLoopNT-out 6.455 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 39.54 APE8-rot-na 32.71 APE67-dihe-in -69.3, -0.31 -58.16, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D1228V None None XRAY 2.631 0.283 0.329 A 309 244 41 0 0 17 [[1078, 1339]] 1.0 8owg TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGB P08581 1060 1343 1390.0 W40:1401 Type3 Inactive DFGout 13.474 7.027 BBAminus DFGAsp-rot-in -143.52, -173.91 -145.15, 96.11 200.22, -29.73 -104.84, 19.11 287.04, 87.7 -144.89, 36.92 out-none out 12.676 Saltbr-none 999.0 HRD-in -57.0, -54.53 71.26, 2.24 none-out-in SNCnoi out-in ActLoopNT-out 8.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.21, 155.54 APE9-dihe-in -138.84, 156.19 APE8-dihe-in -90.42, 73.4 APE8-rot-na 26.27 APE67-dihe-in -74.77, 0.81 -53.95, -37.48 APE12-dist-na 13.969 APE11-dist-na 10.934 APE10-dist-na 9.933 APE9-dist-na 7.283 D1228V None None XRAY 2.631 0.283 0.329 B 309 246 38 0 0 14 [[1078, 1339]] 1.0 8owg TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGC P08581 1060 1343 1390.0 W40:1401 Type3 Inactive DFGout 13.494 7.396 BBAminus DFGAsp-rot-in -137.63, 176.74 -129.85, 94.81 212.98, -42.17 -103.25, 51.6 272.59, 87.18 162.66, 999.0 out-none out 12.719 Saltbr-none 999.0 HRD-in -60.14, -44.34 69.98, -16.33 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.95 APE8-dihe-in -84.26, 62.47 APE8-rot-na 30.42 APE67-dihe-in -68.37, 4.72 -58.51, -48.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.132 D1228V None None XRAY 2.631 0.283 0.329 C 309 235 49 0 0 20 [[1078, 1339]] 1.0 8owg TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OW3A P08581 1058 1345 1390.0 W40:1401 Type3 Inactive DFGout 13.282 6.949 BBAminus DFGAsp-rot-in -144.85, -172.89 -148.19, 116.28 194.24, -22.83 -124.16, 31.55 280.56, 89.39 -106.2, 999.0 out-none out 12.663 Saltbr-none 999.0 HRD-in -58.32, -54.99 72.45, -5.24 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.74 APE8-dihe-in -87.02, 65.42 APE8-rot-na 27.11 APE67-dihe-in -76.81, 1.52 -53.65, -34.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.743 None None None XRAY 2.27 0.247 0.295 A 309 258 30 0 0 20 [[1078, 1339]] 1.0 8ow3 TYR_MET_HUMAN TYR 7.1e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PL4A P04629 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.331 6.751 BBAminus DFGAsp-rot-out 163.32, 156.14 -161.4, 166.2 68.92, 89.64 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.548 Saltbr-out 6.947 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.677 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.774 APE11-dist-na 15.065 APE10-dist-na 10.803 APE9-dist-na 7.259 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311 299 3 0 0 0 [[510, 783]] 1.0 6pl4 TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSPA P04629 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.341 6.918 None DFGAsp-rot-out 147.69, 153.73 -147.15, -178.06 57.89, 82.36 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.506 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.69 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.055 APE10-dist-na 10.661 APE9-dist-na 7.371 None None None XRAY 2.31 0.192 0.255 A 297 293 3 0 0 0 [[510, 783]] 1.0 6nsp TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NPTA P04629 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.438 7.501 None DFGAsp-rot-out 158.18, 155.8 -152.05, 169.87 66.59, 77.8 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.008 Saltbr-out 5.238 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.426 APE11-dist-na 15.187 APE10-dist-na 10.648 APE9-dist-na 7.262 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305 288 10 0 0 0 [[510, 783]] 1.0 6npt TYR_NTRK1_HUMAN TYR 2e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSSA P04629 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.815 7.025 None DFGAsp-rot-out 168.65, 153.78 -158.36, 171.84 65.15, 78.36 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.666 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.068 APE11-dist-na 15.018 APE10-dist-na 10.687 APE9-dist-na 7.449 None None None XRAY 1.97 0.184 0.218 A 311 303 3 0 0 0 [[510, 783]] 1.0 6nss TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6D1YA P04629 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.673 6.856 None DFGAsp-rot-out 169.8, 145.64 -149.42, -179.74 67.03, 86.72 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.052 Saltbr-out 5.442 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.709 APE9-dist-na 7.254 None None None XRAY 1.93 0.179 0.224 A 320 300 16 0 0 4 [[510, 783]] 1.0 6d1y TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMIA P04629 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.102 7.293 None DFGAsp-rot-out 161.69, 152.83 -154.44, 168.25 64.92, -83.35 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.486 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.003 APE11-dist-na 15.654 APE10-dist-na 10.916 APE9-dist-na 7.529 None None None XRAY 1.87 0.21 0.247 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmi TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None DFGAsp-rot-out 156.98, 152.76 -155.56, 161.93 73.62, -85.77 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-na 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMKA P04629 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.367 7.444 None DFGAsp-rot-out 155.23, 152.12 -152.95, 175.79 63.96, -81.36 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.763 Saltbr-out 6.397 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.029 APE11-dist-na 15.416 APE10-dist-na 11.102 APE9-dist-na 7.25 None None None XRAY 2.24 0.227 0.281 A 329 302 5 0 0 0 [[510, 783]] 1.0 5kmk TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMMA P04629 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.368 7.184 None DFGAsp-rot-out 157.73, 155.5 -160.68, 165.48 66.77, -89.3 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.114 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.663 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.548 APE11-dist-na 15.633 APE10-dist-na 11.207 APE9-dist-na 7.428 None None None XRAY 2.12 0.216 0.264 A 329 300 5 0 0 0 [[510, 783]] 1.0 5kmm TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMLA P04629 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.398 7.282 None DFGAsp-rot-out 158.81, 154.45 -158.96, 169.19 65.27, 88.0 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.957 Saltbr-out 5.226 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.512 APE11-dist-na 15.25 APE10-dist-na 11.024 APE9-dist-na 7.223 None None None XRAY 2.01 0.204 0.232 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kml TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMNA P04629 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.55 7.54 None DFGAsp-rot-out 154.23, 154.5 -157.96, 168.93 64.57, -87.9 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.889 Saltbr-out 4.996 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.168 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.561 APE11-dist-na 15.367 APE10-dist-na 11.163 APE9-dist-na 7.323 None None None XRAY 2.14 0.195 0.222 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kmn TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4I4FA Q05397 415 686 1052.0 1BR:702 Type3 Inactive DFGout 13.674 8.178 None DFGAsp-rot-out -137.25, -178.53 -131.85, 30.21 68.51, -15.91 -146.33, 163.88 55.94, 90.52 -101.82, 157.06 out-out out 10.618 Saltbr-out 6.191 HRD-out -98.84, 110.46 -92.47, -29.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 158.93 APE9-dihe-in -71.56, 140.23 APE8-dihe-in -82.88, 69.99 APE8-rot-na 31.14 APE67-dihe-in -67.42, -12.73 -49.69, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.614 APE9-dist-na 8.777 None None None XRAY 1.75 0.188 0.228 A 281 255 17 0 0 14 [[422, 678]] 1.0 4i4f TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1

All / All / Type3

Total number of chains: 149
Active chains: 0
Total number of genes: 20
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 92 61.7% 8OUUB
DFGout None 21 14.1% 6NSSA
DFGin BLBminus 18 12.1% 5R97A
DFGin BLBplus 12 8.1% 4M13A
DFGin BLAminus 3 2.0% 4ZSGA
DFGin BLAplus 2 1.3% 8A2AA
None None 1 0.7% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3F3UB P00523 257 533 533.0 1AW:1 Type3 Inactive DFGout 15.336 9.183 BBAminus DFGAsp-rot-in -141.0, -173.96 -153.88, 116.05 190.7, -21.88 -70.03, -22.13 273.23, 93.9 97.77, 28.5 in-out in 8.179 Saltbr-out 4.092 HRD-in -96.28, -57.27 85.03, -8.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.31 APE8-dihe-in -63.37, 107.9 APE8-rot-na 21.01 APE67-dihe-in -72.88, -5.99 -68.0, -15.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.765 S345C None None XRAY 2.5 0.224 0.281 B 286 259 18 0 0 16 [[267, 518]] 1.0 3f3u Gallus gallus TYR_SRC_CHICK TYR 4.6e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC AKT2 AKT2_HUMAN 8Q61A P31751 1 435 481.0 K06:60501 Type3 Inactive DFGout 18.89 8.016 BBAminus DFGAsp-rot-in -86.01, 164.11 -136.51, 53.07 188.04, 23.44 -106.57, 16.06 303.39, 155.45 -59.47, 122.51 out-out out 16.663 Saltbr-out 14.734 HRD-in -73.93, -39.6 78.27, -25.65 out-out-none SNCoon out-none ActLoopNT-out 15.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.87, 132.41 999.0, 120.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N2D None None XRAY 2.32 0.212 0.263 A 483 382 13 0 0 6 [[152, 409]] 1.0 8q61 Homo sapiens AGC_AKT2_HUMAN AGC 5.3e-99 336.6 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
CMGC CDK2 CDK2_HUMAN 7RXOA P24941 3 298 298.0 80E:302 Type3 Inactive DFGin 9.577 15.209 BLBminus DFGAsp-rot-out -139.06, 169.7 61.6, 49.36 302.38, -34.06 -60.15, 142.75 280.94, 71.13 -90.17, 55.28 out-none out 16.257 Saltbr-none 999.0 HRD-in -84.07, -54.4 80.78, -17.71 none-out-out SNCnoo out-out ActLoopNT-out 9.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.7 APE9-dihe-na -79.88, 129.58 APE8-dihe-in -82.74, 122.09 APE8-rot-in 299.53 APE67-dihe-in -61.07, -23.59 -103.49, 0.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.234 APE9-dist-out 11.072 None None None XRAY 1.38 0.221 0.233 A 298 266 30 0 0 11 [[4, 286]] 1.0 7rxo Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S4TA P24941 3 298 298.0 88O:302 Type3 Inactive DFGin 9.489 14.93 BLBminus DFGAsp-rot-out -139.75, 172.37 54.85, 54.18 308.39, -50.01 -61.18, 140.99 279.06, 68.96 -88.85, 55.03 out-out out 16.133 Saltbr-out 17.267 HRD-in -83.62, -51.24 80.26, -20.24 out-out-out SNCooo out-out ActLoopNT-out 9.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.14, 114.43 APE9-dihe-na -104.15, 134.39 APE8-dihe-in -80.41, 117.61 APE8-rot-in 297.25 APE67-dihe-in -59.04, -28.55 -98.31, -2.72 APE12-dist-out 21.83 APE11-dist-out 15.938 APE10-dist-out 19.475 APE9-dist-out 10.954 None None None XRAY 1.91 0.176 0.218 A 298 293 3 0 0 0 [[4, 286]] 1.0 7s4t Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S7AA P24941 2 298 298.0 8FI:302 Type3 Inactive DFGin 9.329 14.863 BLBminus DFGAsp-rot-out -135.89, 169.74 57.4, 53.57 307.6, -34.28 -62.05, 140.1 280.75, 73.98 -88.85, 60.5 out-none out 16.295 Saltbr-none 999.0 HRD-in -83.29, -52.56 81.61, -18.34 none-out-out SNCnoo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 134.88 APE9-dihe-na -76.39, 137.86 APE8-dihe-in -88.45, 118.46 APE8-rot-in 298.52 APE67-dihe-in -62.81, -25.13 -99.02, 0.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.232 APE9-dist-out 11.121 None None None XRAY 1.7 0.207 0.238 A 298 278 19 0 0 6 [[4, 286]] 1.0 7s7a Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S84A P24941 1 298 298.0 8IL:301 Type3 Inactive DFGin 9.497 14.909 BLBminus DFGAsp-rot-out -138.52, 170.26 59.0, 52.71 303.85, -34.49 -61.4, 138.63 280.38, 69.16 -88.44, 57.68 out-out out 16.574 Saltbr-out 16.91 HRD-in -84.23, -49.7 77.31, -14.87 out-out-out SNCooo out-out ActLoopNT-out 9.341 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 132.74 APE9-dihe-na -86.51, 133.78 APE8-dihe-in -79.23, 128.57 APE8-rot-in 299.16 APE67-dihe-in -62.27, -25.49 -106.32, 3.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.695 APE9-dist-out 10.85 None None None XRAY 2.0 0.2 0.244 A 298 282 16 0 0 6 [[4, 286]] 1.0 7s84 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S85A P24941 3 298 298.0 8IQ:303 Type3 Inactive DFGin 9.781 15.144 BLBminus DFGAsp-rot-out -134.14, 169.78 58.04, 49.92 306.0, -42.69 -58.53, 139.92 281.4, 68.84 -85.04, 54.66 out-out out 16.939 Saltbr-out 18.208 HRD-in -87.86, -51.53 80.52, -16.15 out-out-out SNCooo out-out ActLoopNT-out 9.384 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 138.57 APE9-dihe-na -72.34, 136.21 APE8-dihe-in -90.62, 126.85 APE8-rot-in 294.4 APE67-dihe-in -60.51, -24.54 -104.08, -3.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.471 APE9-dist-out 10.828 None None None XRAY 1.98 0.208 0.252 A 298 281 15 0 0 6 [[4, 286]] 1.0 7s85 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus DFGAsp-rot-out -140.51, 174.83 55.24, 52.61 297.0, -30.77 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7RWFA P24941 1 298 298.0 7TW:60302 Type3 Inactive DFGin 9.475 14.851 BLBminus DFGAsp-rot-out -140.11, 174.11 55.01, 51.54 310.66, -45.1 -61.58, 141.11 278.46, 73.02 -87.62, 59.54 out-out out 16.189 Saltbr-out 17.439 HRD-in -86.88, -54.95 86.13, -18.41 out-out-out SNCooo out-out ActLoopNT-out 9.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -106.87, 114.93 APE9-dihe-na -103.6, 143.12 APE8-dihe-in -86.24, 120.37 APE8-rot-in 298.57 APE67-dihe-in -60.28, -26.78 -101.29, -1.63 APE12-dist-out 21.854 APE11-dist-out 16.026 APE10-dist-out 19.464 APE9-dist-out 10.963 None None None XRAY 1.5 0.193 0.209 A 299 298 0 0 0 0 [[4, 286]] 1.0 7rwf Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK8 CDK8_HUMAN 4F6SA P49336 1 359 464.0 0SQ:60501 Type3 Inactive DFGout 13.878 7.557 BBAminus DFGAsp-rot-in -143.37, 174.31 -133.59, 95.54 194.03, -0.3 -89.33, -12.55 298.0, 127.79 85.97, -154.1 in-in in 8.67 Saltbr-in 2.813 HRD-in -74.89, -55.83 78.59, -0.68 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.84 APE8-dihe-in -132.11, 155.15 APE8-rot-out 82.42 APE67-dihe-in -62.47, -25.65 -106.71, 17.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.87 None None None XRAY 2.6 0.205 0.26 A 405 327 32 0 0 17 [[22, 335]] 1.0 4f6s Homo sapiens CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CDK8 CDK8_HUMAN 4F7JA P49336 1 359 464.0 0SU:60501 Type3 Inactive DFGout 14.423 8.595 BBAminus DFGAsp-rot-in -131.55, -173.38 -148.17, 95.28 192.53, -8.04 -72.43, -38.8 311.88, 131.51 104.34, -133.92 in-in in 8.724 Saltbr-in 2.664 HRD-in -75.51, -51.42 85.3, -13.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -31.87 APE8-dihe-in -70.46, 100.26 APE8-rot-in 296.32 APE67-dihe-in -60.95, -26.84 -87.97, 10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.055 None None None XRAY 2.6 0.229 0.276 A 405 326 33 0 0 18 [[22, 335]] 1.0 4f7j Homo sapiens CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CDK8 CDK8_HUMAN 4F70A P49336 1 359 464.0 0ST:60501 Type3 Inactive None 18.647 14.421 None DFGAsp-rot-in -123.12, -177.92 -154.05, 113.27 191.1, 13.8 -90.85, 999.0 75.63, 12.09 999.0, 999.0 in-in in 8.993 Saltbr-in 3.008 HRD-in -82.85, -48.58 74.91, -2.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 73.37 APE8-dihe-in -133.51, 141.85 APE8-rot-out 58.33 APE67-dihe-in -73.19, -29.13 -108.0, 28.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 3.0 0.204 0.239 A 405 326 33 0 0 20 [[22, 335]] 1.0 4f70 Homo sapiens CMGC_CDK8_HUMAN CMGC 6.1e-82 281.4 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC MAPK14 MK14_HUMAN 3IW8A Q16539 4 352 360.0 HIZ:361 Type3 Inactive DFGout 14.339 10.748 BBAminus DFGAsp-rot-in -128.77, 173.15 -144.49, 96.52 190.46, 7.77 -69.13, -29.38 264.26, 95.46 -57.05, 999.0 in-in in 9.584 Saltbr-in 3.184 HRD-in -68.87, -52.0 80.48, -15.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -40.92 APE8-dihe-out -64.98, -16.01 APE8-rot-out 58.5 APE67-dihe-in -67.61, -18.84 -96.57, -8.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.89 C119S,C162S,A172C,F327L None None XRAY 2.0 0.22 0.298 A 360 334 15 0 0 13 [[24, 308]] 1.0 3iw8 Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFBA Q16539 4 353 360.0 Z87:361 Type3 Inactive DFGout 13.506 8.669 BBAminus DFGAsp-rot-in -137.91, -175.41 -148.69, 98.28 182.67, -5.37 -75.6, 80.49 288.48, 128.29 -32.77, 999.0 in-in in 8.869 Saltbr-in 3.302 HRD-in -68.86, -47.3 79.01, -11.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 142.13 APE8-dihe-out -63.54, -31.96 APE8-rot-in 292.75 APE67-dihe-in -68.43, -9.24 -55.41, -18.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.763 C119S,C162S,A172C,F327L None None XRAY 2.6 0.236 0.32 A 360 333 17 0 0 13 [[24, 308]] 1.0 3lfb Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFCA Q16539 4 354 360.0 Z86:361 Type3 Inactive DFGout 15.084 10.469 BBAminus DFGAsp-rot-in -140.93, 172.03 -136.7, 104.03 194.49, 12.28 -73.11, 19.87 257.43, 81.27 31.49, 999.0 in-in in 9.185 Saltbr-in 2.914 HRD-in -68.27, -48.31 75.76, -5.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.38 APE8-dihe-out -70.67, -45.62 APE8-rot-in 307.9 APE67-dihe-in -82.24, -9.74 -64.34, 0.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.78 C119S,C162S,A172C,F327L None None XRAY 2.8 0.242 0.326 A 360 334 17 0 0 13 [[24, 308]] 1.0 3lfc Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNVA Q16539 5 352 360.0 437:355 Type3 Inactive DFGout 14.572 9.258 BBAminus DFGAsp-rot-in -142.55, -173.27 -145.34, 106.59 186.8, -17.75 -51.19, -52.47 263.96, 85.79 66.07, 29.58 in-in in 8.439 Saltbr-in 2.655 HRD-in -68.73, -54.43 79.33, -18.5 in-out-out SNCioo out-out ActLoopNT-out 15.264 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.26, 134.3 APE9-dihe-na -61.65, -19.68 APE8-dihe-out -63.7, -16.87 APE8-rot-out 57.56 APE67-dihe-in -65.56, -22.72 -113.46, -23.13 APE12-dist-out 19.824 APE11-dist-out 21.1 APE10-dist-out 15.449 APE9-dist-out 11.706 None None None XRAY 2.1 0.188 0.235 A 354 348 0 0 0 0 [[24, 308]] 1.0 3nnv Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNXA Q16539 5 352 360.0 EDD:355 Type3 Inactive DFGout 14.2 9.216 BBAminus DFGAsp-rot-in -135.6, -177.89 -139.59, 108.47 191.86, -3.62 -57.96, -45.51 273.61, 91.9 59.97, 25.47 in-in in 8.607 Saltbr-in 2.887 HRD-in -71.36, -53.19 82.69, -16.33 in-out-out SNCioo out-out ActLoopNT-out 17.237 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nioo APE10-dihe-na -88.62, 104.06 APE9-dihe-na -72.31, 123.14 APE8-dihe-out -62.65, -30.04 APE8-rot-out 108.29 APE67-dihe-in -62.69, -25.91 -61.93, -24.39 APE12-dist-none 999.0 APE11-dist-in 12.992 APE10-dist-out 12.872 APE9-dist-out 10.683 None PTR182 PTR182 XRAY 2.28 0.222 0.285 A 354 337 11 0 0 7 [[24, 308]] 1.0 3nnx Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.7e-85 291.2 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1W82A Q16539 4 355 360.0 L10:1356 Type3 Inactive DFGout 14.069 9.174 BBAminus DFGAsp-rot-in -147.9, -178.18 -145.43, 99.06 189.84, -16.69 -49.9, -42.31 277.8, 103.87 66.12, 29.05 in-in in 8.918 Saltbr-in 2.549 HRD-in -69.25, -58.44 82.74, -19.28 in-out-out SNCioo out-out ActLoopNT-out 15.324 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -133.24, 132.47 APE9-dihe-na -61.88, -19.44 APE8-dihe-out -63.75, -20.33 APE8-rot-out 53.66 APE67-dihe-in -64.33, -18.99 -112.97, -18.8 APE12-dist-out 19.607 APE11-dist-out 20.963 APE10-dist-out 15.264 APE9-dist-out 11.814 None None None XRAY 2.2 0.174 0.235 A 360 352 0 0 0 0 [[24, 308]] 1.0 1w82 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBVA Q16539 4 355 360.0 LI3:1355 Type3 Inactive DFGout 13.811 10.62 BBAminus DFGAsp-rot-in -134.67, -171.45 -143.3, 105.97 189.47, -16.87 -79.38, -25.77 282.68, 115.07 -27.13, 80.56 in-in in 9.443 Saltbr-in 2.665 HRD-in -73.41, -55.51 76.97, -15.29 in-out-out SNCioo out-out ActLoopNT-out 15.672 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -135.39, 133.7 APE9-dihe-na -61.21, -22.55 APE8-dihe-out -53.62, -26.32 APE8-rot-in 304.67 APE67-dihe-in -66.43, -19.77 -114.84, -13.62 APE12-dist-out 19.73 APE11-dist-out 21.028 APE10-dist-out 15.345 APE9-dist-out 11.867 None None None XRAY 2.0 0.18 0.233 A 360 352 0 0 0 0 [[24, 308]] 1.0 1wbv Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HV7A Q16539 5 352 360.0 1AU:361 Type3 Inactive DFGout 14.463 9.132 BBAminus DFGAsp-rot-in -135.81, -172.79 -148.84, 101.39 193.04, -11.97 -62.36, -41.87 280.67, 103.39 51.74, 88.53 in-in in 8.867 Saltbr-in 3.125 HRD-in -79.33, -51.9 86.38, -21.44 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 109.97 APE9-dihe-na -61.86, 118.1 APE8-dihe-out -35.91, -46.58 APE8-rot-in 283.34 APE67-dihe-in -67.06, -23.86 -60.08, -25.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.948 APE9-dist-out 11.13 None None None XRAY 2.4 0.208 0.279 A 360 330 18 0 0 11 [[24, 308]] 1.0 3hv7 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2BAJA Q16539 2 353 360.0 1PP:60401 Type3 Inactive DFGout 14.417 9.252 BBAminus DFGAsp-rot-in -151.05, 178.08 -142.27, 101.23 192.02, -25.16 -49.29, -43.08 274.53, 77.37 57.96, 32.94 in-in in 8.442 Saltbr-in 2.799 HRD-in -68.1, -55.57 80.28, -12.3 in-out-out SNCioo out-out ActLoopNT-out 15.581 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -142.01, 130.0 APE9-dihe-na -85.9, 148.12 APE8-dihe-out -78.24, -30.99 APE8-rot-out 234.7 APE67-dihe-in -63.24, -22.11 -66.59, -20.46 APE12-dist-in 12.668 APE11-dist-out 17.209 APE10-dist-out 14.646 APE9-dist-out 11.597 None None None XRAY 2.25 0.221 0.303 A 365 334 15 0 0 0 [[24, 308]] 1.0 2baj Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.4e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8UA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.796 9.306 BBAminus DFGAsp-rot-in -146.29, -170.4 -144.05, 102.12 191.07, -19.03 -67.29, -15.97 286.91, 115.68 99.79, 999.0 in-in in 9.331 Saltbr-in 3.364 HRD-in -63.28, -51.7 74.53, -20.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.38 APE8-dihe-out -70.85, -30.66 APE8-rot-in 258.69 APE67-dihe-in -65.11, -25.9 -59.1, -20.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.104 F169Y None None XRAY 2.1 0.224 0.285 A 360 332 16 0 0 13 [[24, 308]] 1.0 3o8u Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.4e-84 288.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OBJA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 14.513 11.366 BBAminus DFGAsp-rot-in -154.08, -178.49 -133.48, 111.98 200.89, -22.56 -61.66, -36.04 255.28, 56.42 -103.05, -92.49 in-out in 9.304 Saltbr-out 5.802 HRD-in -72.07, -52.81 76.05, -16.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 143.04 APE8-dihe-out -70.24, -30.65 APE8-rot-out 197.91 APE67-dihe-in -70.14, -17.15 -63.21, -16.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.973 F169R None None XRAY 2.4 0.22 0.287 A 360 332 16 0 0 12 [[24, 308]] 1.0 3obj Homo sapiens CMGC_MAPK14_HUMAN CMGC 2.1e-83 286.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFDA Q16539 4 353 360.0 Z85:361 Type3 Inactive DFGout 14.4 11.185 None DFGAsp-rot-in -141.36, 173.62 -120.67, -179.03 214.8, -33.04 -146.09, 999.0 271.75, 117.44 999.0, 999.0 in-in in 8.854 Saltbr-in 3.232 HRD-in -64.3, -44.5 70.71, -12.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.22 APE8-dihe-out -67.22, -56.7 APE8-rot-in 307.71 APE67-dihe-in -57.89, -22.29 -55.8, -7.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.027 C119S,C162S,A172C,F327L None None XRAY 3.4 0.23 0.305 A 360 331 19 0 0 14 [[24, 308]] 1.0 3lfd Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1KV1A Q16539 5 352 360.0 BMU:391 Type3 Inactive DFGout 13.635 9.556 None DFGAsp-rot-in -159.24, -177.02 -146.07, 100.83 191.42, -13.74 -75.42, -134.45 282.12, 117.71 154.13, 999.0 in-in in 9.163 Saltbr-in 3.578 HRD-in -68.61, -47.67 58.19, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.94 APE8-dihe-out -125.34, -40.47 APE8-rot-in 276.42 APE67-dihe-in -57.32, -20.72 -62.12, -27.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.271 None None None XRAY 2.5 0.24 0.284 A 360 331 17 0 0 13 [[24, 308]] 1.0 1kv1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8TA Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 13.263 10.326 None DFGAsp-rot-in -137.91, -177.55 -138.77, 94.77 187.8, -20.35 -70.74, -1.41 999.0, 999.0 121.86, 999.0 in-out in 9.427 Saltbr-out 4.27 HRD-in -65.83, -55.54 74.19, -14.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 158.65 APE8-dihe-out -42.15, -37.49 APE8-rot-out 44.7 APE67-dihe-in -68.78, -13.14 -104.02, 1.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.491 F169A None None XRAY 2.0 0.229 0.282 A 360 332 16 0 0 13 [[24, 308]] 1.0 3o8t Homo sapiens CMGC_MAPK14_HUMAN CMGC 1.1e-83 287.0 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OC1A Q16539 5 352 360.0 BMU:361 Type3 Inactive DFGout 12.729 11.102 None DFGAsp-rot-in -150.55, -172.96 -134.29, 139.02 208.04, -3.99 -118.77, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.418 Saltbr-in 3.337 HRD-in -75.41, -45.78 70.08, -9.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.76 APE8-dihe-out -49.39, -49.27 APE8-rot-in 287.36 APE67-dihe-in -53.47, -28.65 -54.1, -35.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.094 F169G None None XRAY 2.59 0.229 0.303 A 360 330 18 0 0 14 [[24, 308]] 1.0 3oc1 Homo sapiens CMGC_MAPK14_HUMAN CMGC 3.1e-83 285.5 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK7 MK07_HUMAN 4ZSLA Q13164 53 393 816.0 4QZ:401 Type3 Inactive DFGin 6.779 16.184 BLAminus DFGAsp-rot-in -126.18, -176.13 60.65, 76.15 182.77, 18.08 -96.35, 17.76 285.61, 87.05 -59.31, -35.13 out-out out 10.056 Saltbr-out 9.323 HRD-in -67.2, -48.44 68.55, -1.34 out-in-out SNCoio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -75.33, 121.79 APE9-dihe-na 66.48, -154.79 APE8-dihe-in -93.8, 123.6 APE8-rot-in 308.6 APE67-dihe-in -68.27, -17.62 -46.65, -44.93 APE12-dist-out 14.501 APE11-dist-in 11.223 APE10-dist-in 7.3 APE9-dist-in 4.219 None None None XRAY 2.25 0.179 0.219 A 341 341 0 0 0 0 [[55, 347]] 1.0 4zsl Homo sapiens CMGC_MAPK7_HUMAN CMGC 6.1e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4ZSJA Q13164 50 393 816.0 4R0:405 Type3 Inactive DFGin 6.809 15.895 BLAminus DFGAsp-rot-in -125.1, 178.4 65.55, 77.26 186.66, 38.28 -98.13, 17.11 289.93, 82.18 -56.03, -39.7 in-out in 9.754 Saltbr-out 9.166 HRD-in -64.96, -45.98 65.93, 5.26 out-in-out SNCoio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.12, 119.44 APE9-dihe-na 69.21, -148.69 APE8-dihe-in -101.85, 127.02 APE8-rot-in 308.97 APE67-dihe-in -62.6, -22.74 -46.5, -52.73 APE12-dist-out 14.457 APE11-dist-in 11.232 APE10-dist-in 7.31 APE9-dist-in 4.251 None None None XRAY 2.48 0.17 0.23 A 344 344 0 0 0 0 [[55, 347]] 1.0 4zsj Homo sapiens CMGC_MAPK7_HUMAN CMGC 6.3e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4ZSGA Q13164 47 393 816.0 4QX:406 Type3 Inactive DFGin 6.834 16.18 BLAminus DFGAsp-rot-in -127.2, -178.81 58.37, 79.93 183.69, 19.28 -94.46, 20.05 287.86, 85.24 -54.85, -40.65 in-out in 9.972 Saltbr-out 10.251 HRD-in -63.94, -52.8 75.44, -3.93 out-in-out SNCoio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -79.38, 122.65 APE9-dihe-na 73.61, -149.23 APE8-dihe-in -104.8, 129.27 APE8-rot-in 311.31 APE67-dihe-in -65.93, -17.21 -46.87, -50.9 APE12-dist-out 14.523 APE11-dist-in 11.192 APE10-dist-in 7.339 APE9-dist-in 4.115 None None None XRAY 1.79 0.206 0.235 A 347 347 0 0 0 0 [[55, 347]] 1.0 4zsg Homo sapiens CMGC_MAPK7_HUMAN CMGC 6.5e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
OTHER ERN1 ERN1_HUMAN 4YZ9A O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.93 7.257 None DFGAsp-rot-in -145.42, 154.32 -79.25, -25.27 169.85, 66.54 -113.1, 147.21 74.93, 92.08 -101.05, 170.75 out-out out 11.465 Saltbr-out 6.557 HRD-in -65.78, -56.93 75.18, -20.46 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.49 APE8-dihe-out -91.72, -3.5 APE8-rot-out 69.34 APE67-dihe-inflip 101.89, 14.03 -97.24, 145.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.782 None None None XRAY 2.463 0.238 0.283 A 405 381 22 0 0 17 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9B O75460 563 963 977.0 4K7:1001 Type3 Inactive DFGout 17.04 7.266 None DFGAsp-rot-in -150.4, 164.44 -74.79, -40.79 159.24, 51.75 -115.62, 154.13 77.21, 107.48 -102.62, 170.51 out-out out 12.359 Saltbr-out 7.616 HRD-in -70.74, -51.1 76.22, -19.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 103.24, -20.76 999.0, -159.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 B 405 375 24 0 0 19 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9C O75460 562 964 977.0 4K7:1001 Type3 Inactive DFGout 15.914 7.11 None DFGAsp-rot-out -135.14, 175.91 -93.49, -10.88 55.66, -53.54 -129.03, 149.22 68.81, 88.89 -96.28, -179.45 out-out out 11.562 Saltbr-out 6.749 HRD-in -69.18, -49.88 66.0, -15.77 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.06 APE8-rot-in 308.85 APE67-dihe-inflip 96.07, 16.76 -122.57, 162.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.463 0.238 0.283 C 405 378 25 0 0 18 [[571, 832]] 1.0 4yz9 Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
STE MAP2K1 MP2K1_HUMAN 7MFDB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.404 15.002 BLBplus DFGAsp-rot-in -158.62, 167.12 60.92, 63.61 183.7, 3.0 -97.12, -175.46 63.42, 90.2 -85.78, 95.16 out-out out 16.323 Saltbr-out 15.726 HRD-in -63.97, -52.79 67.43, -4.72 out-out-out SNCooo out-out ActLoopNT-out 9.676 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -74.44, -63.74 APE9-dihe-na 63.29, 177.26 APE8-dihe-out -134.0, -13.26 APE8-rot-out 186.3 APE67-dihe-out -128.3, 117.83 -113.33, 134.88 APE12-dist-out 15.876 APE11-dist-out 14.211 APE10-dist-out 20.349 APE9-dist-out 12.751 None None None EM 3.66 999.0 999.0 B 393 293 39 0 0 0 [[68, 361]] 1.0 7mfd Homo sapiens STE_MAP2K1_HUMAN STE 2.5e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O2ZB Q02750 52 383 393.0 CHU:401 Type3 Inactive DFGin 5.693 14.557 BLBplus DFGAsp-rot-out -161.53, 165.82 61.62, 61.08 322.28, -30.7 -96.61, -171.26 43.54, 100.17 -85.43, 98.09 out-out out 16.596 Saltbr-out 16.461 HRD-in -72.32, -46.17 67.98, -6.22 out-out-out SNCooo out-out ActLoopNT-out 9.647 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -91.74, -52.46 APE9-dihe-na 52.82, -171.67 APE8-dihe-out -137.35, -7.44 APE8-rot-out 199.8 APE67-dihe-out -140.63, 115.25 -121.25, 136.62 APE12-dist-out 16.396 APE11-dist-out 14.248 APE10-dist-out 20.354 APE9-dist-out 13.12 None None None EM 3.83 999.0 999.0 B 393 293 39 0 0 0 [[68, 361]] 1.0 9o2z Homo sapiens STE_MAP2K1_HUMAN STE 2.5e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 6.813 13.768 BLBplus DFGAsp-rot-in -157.46, 170.37 59.28, 64.98 193.79, -2.98 -117.48, 165.11 40.29, 81.19 -81.1, 74.19 out-out out 15.431 Saltbr-out 17.41 HRD-in -75.24, -42.64 72.38, -11.77 out-out-out SNCooo out-out ActLoopNT-out 9.208 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.37, -62.71 APE9-dihe-na 103.09, 102.94 APE8-dihe-out -88.38, -48.33 APE8-rot-out 62.02 APE67-dihe-out -122.1, 131.17 -98.78, 143.35 APE12-dist-out 16.696 APE11-dist-out 18.126 APE10-dist-out 22.852 APE9-dist-out 12.424 S218A,S222A None None EM 4.36 999.0 999.0 B 394 278 51 0 0 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXAD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 6.188 15.038 BLBplus DFGAsp-rot-out -161.59, 167.64 63.71, 27.36 291.69, -29.13 -77.56, 162.55 63.45, 90.49 -80.72, 76.54 out-out out 17.613 Saltbr-out 18.798 HRD-in -103.62, -49.66 71.76, -9.27 out-out-out SNCooo out-out ActLoopNT-out 9.797 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na 56.39, -81.94 APE9-dihe-na 48.87, 69.85 APE8-dihe-out -71.23, -18.7 APE8-rot-out 181.91 APE67-dihe-out -127.48, 156.86 -129.99, 139.21 APE12-dist-out 19.162 APE11-dist-out 16.676 APE10-dist-out 21.374 APE9-dist-out 12.272 S218A,S222A None None EM 4.36 999.0 999.0 D 394 275 50 0 0 0 [[68, 361]] 1.0 9axa Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCB Q02750 52 380 393.0 A1AHE:401 Type3 Inactive DFGin 5.979 13.857 BLBplus DFGAsp-rot-out -156.34, 159.86 58.05, 51.28 302.77, -6.22 -90.68, 168.57 45.43, 79.18 -80.79, 77.37 out-out out 15.525 Saltbr-out 16.483 HRD-in -82.47, -42.11 70.94, -10.4 out-out-out SNCooo out-out ActLoopNT-out 9.445 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -71.13, -44.57 APE9-dihe-na 100.23, 100.79 APE8-dihe-out -96.55, -49.37 APE8-rot-out 61.77 APE67-dihe-out -125.36, 134.49 -112.13, 139.3 APE12-dist-out 16.732 APE11-dist-out 18.062 APE10-dist-out 22.927 APE9-dist-out 12.623 S218A,S222A None None EM 4.16 999.0 999.0 B 394 278 51 0 0 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXCD Q02750 59 383 393.0 A1AHE:401 Type3 Inactive DFGin 5.944 14.943 BLBplus DFGAsp-rot-out -155.71, -173.77 60.85, 40.35 292.65, -28.69 -100.84, 165.38 63.0, 90.55 -83.19, 80.54 out-out out 17.464 Saltbr-out 19.882 HRD-in -94.68, -47.55 72.62, -11.59 out-out-out SNCooo out-out ActLoopNT-out 9.375 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na 51.94, -88.31 APE9-dihe-na 51.11, 70.23 APE8-dihe-out -66.0, -35.69 APE8-rot-in 292.49 APE67-dihe-out -158.48, 126.03 -105.47, -179.54 APE12-dist-out 18.774 APE11-dist-out 17.062 APE10-dist-out 21.141 APE9-dist-out 12.44 S218A,S222A None None EM 4.16 999.0 999.0 D 394 275 50 0 0 0 [[68, 361]] 1.0 9axc Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UD Q02750 31 380 393.0 CHU:401 Type3 Inactive DFGin 6.258 14.245 BLBplus DFGAsp-rot-out -155.2, 170.07 62.24, 48.49 290.44, -9.58 -103.46, 163.38 44.86, 81.23 -80.64, 82.9 out-out out 15.804 Saltbr-out 15.56 HRD-in -72.61, -47.48 72.0, -5.51 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.99, 151.57 APE9-dihe-na -129.02, 151.01 APE8-dihe-out -101.49, -25.69 APE8-rot-in 295.14 APE67-dihe-out -149.54, 133.77 -134.81, 174.59 APE12-dist-out 17.407 APE11-dist-out 17.558 APE10-dist-out 22.648 APE9-dist-out 12.754 S218A,S222A None None XRAY 2.91 0.232 0.264 D 395 317 33 0 0 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UF Q02750 30 380 393.0 CHU:401 Type3 Inactive DFGin 6.24 14.242 BLBplus DFGAsp-rot-out -149.4, 162.55 67.26, 47.9 291.19, -5.21 -103.2, 163.92 46.52, 88.85 -79.29, 85.22 out-out out 15.539 Saltbr-out 16.236 HRD-in -74.73, -46.69 72.92, -6.37 out-out-out SNCooo out-out ActLoopNT-out 9.834 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -124.83, 125.43 APE9-dihe-na -156.49, 116.77 APE8-dihe-out -98.23, -8.63 APE8-rot-in 320.21 APE67-dihe-out -147.81, 133.84 -133.15, 172.65 APE12-dist-out 18.664 APE11-dist-out 16.786 APE10-dist-out 21.173 APE9-dist-out 12.537 S218A,S222A None None XRAY 2.91 0.232 0.264 F 395 322 29 0 0 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK1 PAK1_HUMAN 4ZJIA Q13153 254 542 545.0 4OQ:601 Type3 Inactive DFGout 14.486 7.862 BBAminus DFGAsp-rot-in -124.98, 172.53 -139.37, 60.86 176.3, 32.23 -76.04, -0.31 290.5, 165.49 -101.27, 2.8 out-out out 11.456 Saltbr-out 9.179 HRD-in -74.01, -52.86 71.92, 1.18 out-out-out SNCooo out-out ActLoopNT-out 4.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.27, 143.67 APE9-dihe-na 128.32, -164.34 APE8-dihe-in -119.07, 120.68 APE8-rot-in 308.34 APE67-dihe-in -57.07, -27.71 -45.34, -50.35 APE12-dist-in 12.553 APE11-dist-in 13.876 APE10-dist-out 8.621 APE9-dist-in 3.47 None None None XRAY 1.99 0.192 0.22 A 299 278 11 0 0 6 [[270, 521]] 1.0 4zji Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIB Q13153 254 540 545.0 4OQ:601 Type3 Inactive DFGout 14.347 7.911 BBAminus DFGAsp-rot-in -122.99, 169.12 -135.22, 63.32 177.32, 36.71 -78.42, -1.05 289.36, 166.77 -102.4, 3.7 out-out out 11.355 Saltbr-out 9.5 HRD-in -73.68, -52.57 71.67, 0.82 out-out-out SNCooo out-out ActLoopNT-out 4.463 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -121.49, 143.59 APE9-dihe-na 127.1, -165.24 APE8-dihe-in -117.4, 119.62 APE8-rot-in 306.54 APE67-dihe-in -58.04, -25.35 -40.93, -53.52 APE12-dist-in 12.464 APE11-dist-in 13.856 APE10-dist-out 8.632 APE9-dist-in 3.458 None None None XRAY 1.99 0.192 0.22 B 299 276 11 0 0 6 [[270, 521]] 1.0 4zji Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJIC Q13153 250 541 545.0 4OQ:601 Type3 Inactive DFGout 14.215 7.811 BBAminus DFGAsp-rot-in -121.31, 171.98 -130.54, 60.34 181.05, 40.62 -81.43, -2.47 290.92, 169.61 -101.24, 4.12 out-out out 11.332 Saltbr-out 7.131 HRD-in -69.29, -53.03 70.55, 2.57 out-out-out SNCooo out-out ActLoopNT-out 4.697 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.35, 146.99 APE9-dihe-na -60.27, 135.04 APE8-dihe-in -113.96, 115.83 APE8-rot-in 300.08 APE67-dihe-in -103.44, 21.24 -64.25, -21.29 APE12-dist-out 15.886 APE11-dist-out 15.167 APE10-dist-out 10.107 APE9-dist-out 8.616 None None None XRAY 1.99 0.192 0.22 C 299 281 11 0 0 5 [[270, 521]] 1.0 4zji Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJID Q13153 253 541 545.0 4OQ:601 Type3 Inactive DFGout 14.159 7.854 BBAminus DFGAsp-rot-in -123.8, 172.68 -134.23, 62.09 175.61, 36.84 -78.43, -2.16 289.23, 167.94 -100.19, 2.82 out-out out 11.24 Saltbr-out 7.121 HRD-in -70.67, -52.48 69.45, 4.83 out-in-out SNCoio in-out ActLoopNT-in 3.118 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.08, 151.63 APE9-dihe-na -63.3, 137.02 APE8-dihe-in -115.16, 115.5 APE8-rot-in 303.37 APE67-dihe-in -103.69, 23.11 -64.43, -20.74 APE12-dist-out 15.883 APE11-dist-out 15.53 APE10-dist-out 10.143 APE9-dist-out 8.504 None None None XRAY 1.99 0.192 0.22 D 299 280 9 0 0 4 [[270, 521]] 1.0 4zji Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJA Q13153 249 539 545.0 4OR:601 Type3 Inactive DFGout 14.93 7.884 BBAminus DFGAsp-rot-in -121.34, 171.37 -136.52, 66.59 177.56, 28.21 -79.2, -3.71 291.13, 159.73 -99.9, 1.22 out-out out 12.071 Saltbr-out 9.378 HRD-in -72.7, -51.01 69.62, -1.62 out-out-out SNCooo out-out ActLoopNT-out 4.327 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -108.73, 140.93 APE9-dihe-na 129.99, -160.2 APE8-dihe-in -123.0, 117.69 APE8-rot-in 310.93 APE67-dihe-in -52.25, -30.59 -37.79, -59.06 APE12-dist-in 12.193 APE11-dist-in 13.862 APE10-dist-out 8.608 APE9-dist-in 3.296 None None None XRAY 2.2 0.203 0.238 A 299 280 11 0 0 7 [[270, 521]] 1.0 4zjj Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJB Q13153 251 539 545.0 4OR:601 Type3 Inactive DFGout 14.948 7.932 BBAminus DFGAsp-rot-in -119.95, 170.64 -136.17, 65.87 175.85, 40.96 -79.78, -2.78 291.31, 160.73 -99.76, -0.39 out-out out 12.019 Saltbr-out 9.348 HRD-in -71.08, -50.26 68.41, 0.81 out-out-out SNCooo out-out ActLoopNT-out 4.306 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -110.29, 139.33 APE9-dihe-na 127.62, -164.58 APE8-dihe-in -118.42, 122.35 APE8-rot-in 307.66 APE67-dihe-in -57.94, -28.38 -41.45, -53.66 APE12-dist-in 13.115 APE11-dist-in 13.841 APE10-dist-out 8.56 APE9-dist-in 3.322 None None None XRAY 2.2 0.203 0.238 B 299 277 12 0 0 7 [[270, 521]] 1.0 4zjj Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJC Q13153 251 542 545.0 4OR:601 Type3 Inactive DFGout 14.688 7.965 BBAminus DFGAsp-rot-in -117.77, 169.13 -137.11, 67.47 180.55, 26.2 -83.74, 26.97 291.43, 162.22 -146.25, 999.0 out-none out 11.922 Saltbr-none 999.0 HRD-in -69.95, -52.05 69.27, 1.3 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -119.64, 146.88 APE9-dihe-na -53.72, 136.85 APE8-dihe-in -114.06, 116.5 APE8-rot-in 303.53 APE67-dihe-in -106.18, 21.65 -68.59, -18.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.339 None None None XRAY 2.2 0.203 0.238 C 299 276 16 0 0 7 [[270, 521]] 1.0 4zjj Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZJJD Q13153 252 541 545.0 4OR:601 Type3 Inactive DFGout 13.746 8.374 BBAminus DFGAsp-rot-in -122.31, 164.62 -155.38, 60.52 184.47, 33.47 -68.67, -25.53 302.03, 128.76 -82.18, -4.05 out-none out 11.407 Saltbr-none 999.0 HRD-in -69.6, -54.19 71.18, 0.18 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -124.0, 135.82 APE9-dihe-na -50.29, 114.73 APE8-dihe-in -106.44, 108.75 APE8-rot-in 304.37 APE67-dihe-in -111.14, 19.03 -62.05, -15.3 APE12-dist-out 16.261 APE11-dist-out 16.538 APE10-dist-out 10.957 APE9-dist-out 8.242 None None None XRAY 2.2 0.203 0.238 D 299 274 13 0 0 4 [[270, 521]] 1.0 4zjj Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 324.9 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 4ZLOA Q13153 250 543 545.0 4PV:601 Type3 Inactive DFGout 12.793 7.554 None DFGAsp-rot-in -124.62, -179.06 -146.97, -83.67 211.45, -6.5 75.06, -28.03 305.7, 127.25 125.56, 999.0 out-out out 10.827 Saltbr-out 5.775 HRD-in -62.03, -53.17 80.12, -16.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na -89.92, 112.03 APE9-dihe-na 92.48, 159.15 APE8-dihe-in -79.66, 123.09 APE8-rot-out 71.08 APE67-dihe-out -53.9, -30.99 -83.68, 58.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.202 None TPO423 TPO423 XRAY 2.5 0.196 0.222 A 297 278 16 0 0 9 [[270, 521]] 1.0 4zlo Homo sapiens STE_PAK1_HUMAN STE 2.1e-95 325.0 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
TKL LIMK1 LIMK1_HUMAN 7ATUA P53667 330 634 647.0 RXN:60701 Type3 Inactive DFGout 14.988 10.001 BBAminus DFGAsp-rot-in -109.21, 174.28 -142.39, 83.58 164.18, 11.1 -74.29, -18.32 285.18, 140.01 -111.7, 18.04 out-out out 16.084 Saltbr-out 15.451 HRD-in -57.8, -51.16 74.51, -19.19 out-out-out SNCooo out-out ActLoopNT-out 4.329 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -67.49, -72.98 APE9-dihe-na -69.77, -144.94 APE8-dihe-in -75.87, 154.24 APE8-rot-na 319.69 APE67-dihe-in -61.11, -47.04 -83.72, 16.19 APE12-dist-in 12.865 APE11-dist-in 10.208 APE10-dist-out 8.797 APE9-dist-out 10.305 None None None XRAY 2.8 0.244 0.316 A 310 275 26 0 0 21 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUB P53667 330 636 647.0 RXN:60701 Type3 Inactive DFGout 14.871 10.385 BBAminus DFGAsp-rot-in -106.42, 171.63 -143.53, 69.8 166.47, 38.77 -63.76, -14.73 294.73, 133.01 -108.57, -0.53 out-out out 15.698 Saltbr-out 15.929 HRD-in -85.21, -51.0 77.42, -16.83 out-out-out SNCooo out-out ActLoopNT-out 4.354 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -53.4, -74.11 APE9-dihe-na -79.86, -149.85 APE8-dihe-in -70.91, 144.09 APE8-rot-na 286.44 APE67-dihe-in -64.41, -40.03 -82.97, 20.25 APE12-dist-in 12.959 APE11-dist-in 10.358 APE10-dist-out 8.533 APE9-dist-out 10.077 None None None XRAY 2.8 0.244 0.316 B 310 286 21 0 0 20 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUC P53667 350 632 647.0 RXN:60701 Type3 Inactive DFGout 14.718 10.033 BBAminus DFGAsp-rot-in -88.15, 177.18 -140.99, 72.99 167.73, 87.1 -70.21, -9.41 281.23, 139.59 -112.2, 13.51 out-none out 16.334 Saltbr-none 999.0 HRD-in -66.72, -54.87 73.93, -4.49 none-out-none SNCnon out-none ActLoopNT-out 4.173 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.36 APE8-rot-na 315.64 APE67-dihe-in -46.43, -53.49 -85.62, 16.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.244 0.316 C 310 244 50 0 0 26 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 7ATUD P53667 354 632 647.0 RXN:60701 Type3 Inactive DFGout 15.331 10.224 BBAminus DFGAsp-rot-in -128.0, -173.91 -147.27, 77.77 191.36, 11.05 -61.68, -36.22 282.23, 139.99 -104.61, 32.02 out-none out 15.918 Saltbr-none 999.0 HRD-in -81.48, -48.99 75.04, -24.96 none-out-out SNCnoo out-out ActLoopNT-out 4.359 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 90.29 APE8-dihe-in -64.34, 138.15 APE8-rot-none 999.0 APE67-dihe-in -66.61, -40.13 -99.55, 33.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.651 None None None XRAY 2.8 0.244 0.316 D 310 243 50 0 0 25 [[339, 606]] 1.0 7atu Homo sapiens TKL_LIMK1_HUMAN TKL 4.6e-77 265.1 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK2 LIMK2_HUMAN 4TPTA P53671 330 631 638.0 35H:701 Type3 Inactive DFGout 16.096 11.142 BBAminus DFGAsp-rot-in -114.59, 179.84 -146.01, 83.03 175.52, 22.11 -70.78, -31.53 290.09, 109.97 -82.43, -2.78 out-out out 15.862 Saltbr-out 16.376 HRD-in -70.45, -54.99 74.1, -7.22 out-out-out SNCooo out-out ActLoopNT-out 4.568 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -135.17, 156.48 APE9-dihe-na 121.28, -168.66 APE8-dihe-in -107.67, 124.96 APE8-rot-na 184.54 APE67-dihe-in -64.31, -24.66 -54.17, -26.81 APE12-dist-in 12.014 APE11-dist-out 14.643 APE10-dist-out 8.775 APE9-dist-in 3.89 None None None XRAY 2.6 0.223 0.274 A 303 279 23 0 0 23 [[331, 603]] 1.0 4tpt Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 4TPTB P53671 330 632 638.0 35H:701 Type3 Inactive DFGout 16.355 11.034 BBAminus DFGAsp-rot-in -130.75, -177.01 -149.57, 73.72 182.67, 23.33 -61.92, -29.69 288.54, 113.54 -95.75, 7.29 out-out out 15.844 Saltbr-out 15.526 HRD-in -72.14, -56.53 86.02, -32.37 out-out-out SNCooo out-out ActLoopNT-out 4.602 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooi APE10-dihe-na -134.67, 147.66 APE9-dihe-na 124.79, 175.82 APE8-dihe-in -86.47, 130.25 APE8-rot-na 184.44 APE67-dihe-in -70.78, -18.97 -49.94, -29.41 APE12-dist-in 12.536 APE11-dist-out 14.694 APE10-dist-out 8.83 APE9-dist-in 4.468 None None None XRAY 2.6 0.223 0.274 B 303 277 26 0 0 26 [[331, 603]] 1.0 4tpt Homo sapiens TKL_LIMK2_HUMAN TKL 7e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 5NXDB P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 15.929 9.622 BBAminus DFGAsp-rot-in -120.85, -179.43 -146.81, 73.71 187.77, 6.08 -62.47, -25.15 278.45, 45.25 -102.04, 2.18 out-out out 15.912 Saltbr-out 15.763 HRD-in -73.52, -53.98 77.3, -13.62 out-out-none SNCoon out-none ActLoopNT-out 4.503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.09, -26.34 999.0, 50.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 B 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd Homo sapiens TKL_LIMK2_HUMAN TKL 7.2e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL LIMK2 LIMK2_HUMAN 5NXDA P53671 330 632 638.0 9D8:701 Type3 Inactive DFGout 18.215 8.199 None DFGAsp-rot-in -133.95, 177.46 -146.72, 77.25 180.57, 19.03 -55.91, -32.79 190.69, 79.33 -96.52, 3.25 out-out out 16.007 Saltbr-out 14.828 HRD-in -75.21, -55.71 76.14, -4.58 out-out-none SNCoon out-none ActLoopNT-out 4.382 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.14, -25.71 999.0, -20.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.197 0.23 A 305 271 32 0 0 32 [[331, 603]] 1.0 5nxd Homo sapiens TKL_LIMK2_HUMAN TKL 7.2e-77 264.5 3 266 264 468 469 470 472 474 360 376 380 448 450 449 451 528 516 511 510 509 508 507 506 505 406 LIM domain kinase 2
TKL RIPK1 RIPK1_HUMAN 9MZYA Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.417 8.594 BBAminus DFGAsp-rot-in -121.56, 163.73 -131.53, 69.41 181.05, 25.67 -69.13, -26.9 298.04, 169.8 -86.04, 2.22 out-out out 14.107 Saltbr-out 12.369 HRD-in -64.46, -51.93 74.85, -2.94 out-out-out SNCooo out-out ActLoopNT-out 5.757 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -38.39 APE8-dihe-out -63.39, -46.19 APE8-rot-out 52.35 APE67-dihe-in -66.56, -26.22 -73.65, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.629 None None None XRAY 2.32 0.242 0.315 A 287 266 21 0 0 11 [[17, 287]] 1.0 9mzy Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZYB Q13546 8 294 671.0 A1BU6:301 Type3 Inactive DFGout 13.256 8.174 BBAminus DFGAsp-rot-in -120.1, 168.45 -128.87, 68.39 181.49, 22.28 -67.18, -24.35 298.87, 170.09 -81.57, -2.83 out-out out 13.682 Saltbr-out 12.765 HRD-in -64.72, -49.57 76.17, -4.64 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -55.1 APE8-dihe-out -64.67, -43.51 APE8-rot-in 298.41 APE67-dihe-in -63.01, -29.76 -69.62, -21.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.549 None None None XRAY 2.32 0.242 0.315 B 287 276 11 0 0 7 [[17, 287]] 1.0 9mzy Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.7 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZZB Q13546 7 294 671.0 A1BU5:301 Type3 Inactive DFGout 12.91 8.093 BBAminus DFGAsp-rot-in -123.12, 159.01 -125.1, 65.1 192.29, -20.92 -71.49, -24.77 295.21, 165.65 -63.79, -21.88 out-out out 13.71 Saltbr-out 11.064 HRD-in -62.15, -53.84 85.81, -19.41 out-out-out SNCooo out-out ActLoopNT-out 5.831 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.81 APE8-dihe-out -60.77, -43.31 APE8-rot-out 60.81 APE67-dihe-in -60.82, -28.84 -40.61, -46.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.68 0.229 0.272 B 288 273 15 0 0 11 [[17, 287]] 1.0 9mzz Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZXA Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.155 8.608 BBAminus DFGAsp-rot-in -120.41, 164.67 -130.16, 69.77 182.71, 26.46 -71.17, -32.11 302.55, 177.42 -76.49, -1.63 out-out out 13.684 Saltbr-out 12.721 HRD-in -65.64, -50.76 75.88, -9.5 out-out-out SNCooo out-out ActLoopNT-out 5.537 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 34.89 APE8-dihe-in -83.2, 116.64 APE8-rot-out 186.76 APE67-dihe-in -69.05, -25.68 -94.99, 5.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.474 None None None XRAY 2.53 0.217 0.263 A 289 265 24 0 0 17 [[17, 287]] 1.0 9mzx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9MZXB Q13546 6 294 671.0 A1BU4:301 Type3 Inactive DFGout 13.385 8.604 BBAminus DFGAsp-rot-in -119.33, 165.52 -131.66, 72.61 180.15, 28.94 -71.75, -33.33 299.78, 172.5 -85.72, 10.29 out-out out 13.591 Saltbr-out 12.641 HRD-in -65.63, -49.62 75.8, -10.44 out-out-out SNCooo out-out ActLoopNT-out 5.433 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.61 APE8-dihe-in -77.58, 125.06 APE8-rot-out 189.43 APE67-dihe-in -65.68, -27.84 -90.79, 1.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.082 None None None XRAY 2.53 0.217 0.263 B 289 268 21 0 0 11 [[17, 287]] 1.0 9mzx Homo sapiens TKL_RIPK1_HUMAN TKL 1.2e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C3EA Q13546 9 293 671.0 EJY:301 Type3 Inactive DFGout 13.211 8.704 BBAminus DFGAsp-rot-in -130.6, 166.87 -129.4, 74.2 188.21, 18.77 -68.21, -19.66 307.39, 166.79 -86.61, -13.09 out-out out 13.511 Saltbr-out 13.358 HRD-out -69.12, 116.26 -89.73, 2.91 out-out-out SNCooo out-out ActLoopNT-out 5.346 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -66.6 APE8-dihe-out -78.73, -34.83 APE8-rot-out 76.27 APE67-dihe-in -63.09, -35.77 -52.34, -36.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.672 None None None XRAY 2.6 0.261 0.307 A 297 258 27 0 0 17 [[17, 287]] 1.0 6c3e Homo sapiens TKL_RIPK1_HUMAN TKL 1.7e-72 250.1 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITHA Q13546 8 294 671.0 RCM:307 Type3 Inactive DFGout 14.111 8.042 BBAminus DFGAsp-rot-in -124.73, 172.6 -138.48, 68.81 179.15, 23.28 -68.88, -22.32 295.59, 2.39 -91.07, 2.58 out-out out 13.598 Saltbr-out 12.965 HRD-in -65.52, -52.94 79.64, -21.46 out-out-out SNCooo out-out ActLoopNT-out 5.125 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.47 APE8-dihe-in -73.02, 143.29 APE8-rot-in 249.4 APE67-dihe-in -62.29, -27.12 -114.9, 22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.706 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 A 294 247 40 0 0 19 [[17, 287]] 1.0 4ith Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITHB Q13546 7 294 671.0 RCM:307 Type3 Inactive DFGout 13.911 7.88 BBAminus DFGAsp-rot-in -124.36, 170.84 -137.49, 67.98 177.85, 28.12 -68.97, -21.27 308.9, 171.62 -88.43, 4.67 out-out out 13.671 Saltbr-out 12.354 HRD-in -66.08, -61.08 99.79, -41.26 out-out-out SNCooo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.33 APE8-dihe-out -80.2, -0.81 APE8-rot-out 76.21 APE67-dihe-in -69.94, -29.23 -70.53, -20.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.372 C34A,C127A,C233A,C240A None None XRAY 2.25 0.222 0.247 B 294 270 18 0 0 12 [[17, 287]] 1.0 4ith Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITIA Q13546 8 294 671.0 1HW:301 Type3 Inactive DFGout 14.809 7.536 BBAminus DFGAsp-rot-in -119.39, 171.24 -131.64, 70.92 187.85, 10.43 -77.19, -1.86 301.33, 175.38 -111.16, 12.31 out-out out 14.461 Saltbr-out 12.021 HRD-in -63.67, -39.02 58.78, 3.1 out-out-out SNCooo out-out ActLoopNT-out 5.063 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 135.54 APE9-dihe-na -28.2, -40.78 APE8-dihe-out -49.5, 2.2 APE8-rot-out 126.42 APE67-dihe-in -74.62, -10.45 -88.53, -16.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.612 APE9-dist-out 11.919 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 A 294 272 15 0 0 10 [[17, 287]] 1.0 4iti Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 4ITIB Q13546 7 294 671.0 1HW:301 Type3 Inactive DFGout 15.287 8.279 BBAminus DFGAsp-rot-in -133.02, 174.0 -136.87, 74.76 191.45, -4.85 -71.37, -1.88 298.09, 0.08 -118.72, 6.02 out-out out 14.736 Saltbr-out 12.105 HRD-in -67.98, -50.79 78.94, -25.18 out-out-out SNCooo out-out ActLoopNT-out 5.029 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -36.75 APE8-dihe-out -48.23, -36.55 APE8-rot-out 178.41 APE67-dihe-in -64.1, -17.64 -60.59, -39.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.503 C34A,C127A,C233A,C240A None None XRAY 2.86 0.229 0.267 B 294 270 18 0 0 11 [[17, 287]] 1.0 4iti Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.6 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NYHA Q13546 8 294 671.0 L8D:301 Type3 Inactive DFGout 13.435 9.94 BBAminus DFGAsp-rot-in -117.53, 173.88 -134.6, 59.12 180.97, 29.37 -68.75, -26.25 307.46, 178.63 -80.82, 2.01 out-out out 14.527 Saltbr-out 12.436 HRD-in -67.92, -54.26 77.85, -10.18 out-out-out SNCooo out-out ActLoopNT-out 6.112 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.11 APE8-dihe-in -70.09, 140.73 APE8-rot-out 198.89 APE67-dihe-in -52.04, -30.58 -103.66, -3.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.748 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 A 296 265 22 0 0 12 [[17, 287]] 1.0 6nyh Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NYHB Q13546 11 294 671.0 L8D:301 Type3 Inactive DFGout 13.932 9.865 BBAminus DFGAsp-rot-in -122.04, 173.92 -132.13, 59.75 185.19, 23.07 -67.23, -24.7 302.43, 2.51 -86.8, 3.14 out-out out 14.458 Saltbr-out 12.191 HRD-in -67.08, -53.83 81.99, -19.6 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -85.36 APE8-dihe-in -72.43, 144.74 APE8-rot-out 184.05 APE67-dihe-in -66.66, -21.12 -105.82, 2.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 C34A,C127A,C233A,C240A None None XRAY 2.1 0.206 0.246 B 296 246 38 0 0 18 [[17, 287]] 1.0 6nyh Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q31A Q13546 7 294 671.0 A1CNU:301 Type3 Inactive DFGout 13.735 8.23 BBAminus DFGAsp-rot-in -120.57, 170.34 -130.15, 58.16 181.17, 27.05 -63.68, -22.9 293.63, 177.4 -82.91, 0.44 out-out out 13.869 Saltbr-out 11.761 HRD-in -67.33, -55.79 80.06, -9.46 out-out-out SNCooo out-out ActLoopNT-out 6.088 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.72 APE8-rot-out 187.62 APE67-dihe-in -62.14, -27.07 -101.34, -1.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.05 0.187 0.222 A 296 269 19 0 0 12 [[17, 287]] 1.0 9q31 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32A Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.528 8.226 BBAminus DFGAsp-rot-in -121.4, 167.22 -125.99, 62.31 194.01, 28.99 -66.66, -26.07 287.26, 169.09 -79.79, -0.98 out-out out 14.14 Saltbr-out 12.229 HRD-in -66.73, -48.33 74.89, -10.1 out-out-out SNCooo out-out ActLoopNT-out 5.546 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 27.12 APE8-dihe-in -71.54, 159.66 APE8-rot-out 185.13 APE67-dihe-in -62.84, -25.84 -113.42, -0.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.855 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 A 296 266 22 0 0 12 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32B Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.34 8.34 BBAminus DFGAsp-rot-in -125.85, 168.27 -125.45, 64.08 186.92, 57.88 -70.16, -25.81 289.07, 162.55 -79.65, -1.07 out-out out 14.45 Saltbr-out 13.417 HRD-in -68.2, -50.31 78.72, -10.28 out-out-out SNCooo out-out ActLoopNT-out 5.817 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.67 APE8-rot-out 168.75 APE67-dihe-in -63.25, -31.84 -91.02, 4.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 B 296 251 36 0 0 18 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32C Q13546 6 293 671.0 A1CNV:301 Type3 Inactive DFGout 14.46 8.281 BBAminus DFGAsp-rot-in -120.28, 170.4 -126.9, 54.43 197.64, 68.53 -63.55, -25.46 293.16, 167.28 -77.54, -4.89 out-out out 13.586 Saltbr-out 12.769 HRD-in -69.24, -48.43 74.25, -12.6 out-out-out SNCooo out-out ActLoopNT-out 6.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -164.99 APE8-dihe-in -75.87, 151.54 APE8-rot-out 168.79 APE67-dihe-in -61.95, -25.0 -103.03, -0.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 C 296 259 29 0 0 17 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9Q32D Q13546 8 294 671.0 A1CNV:301 Type3 Inactive DFGout 14.457 8.195 BBAminus DFGAsp-rot-in -119.22, 172.55 -131.06, 63.91 185.62, 55.86 -69.23, -20.15 294.44, 171.06 -85.09, -1.42 out-none out 14.021 Saltbr-none 999.0 HRD-in -82.45, -48.15 73.95, -16.29 none-out-out SNCnoo out-out ActLoopNT-out 5.764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 25.84 APE8-dihe-in -75.4, 152.13 APE8-rot-out 189.23 APE67-dihe-in -64.73, -21.38 -109.94, 2.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.29 C34A,C127A,C233A,C240A None None XRAY 2.49 0.189 0.233 D 296 250 37 0 0 19 [[17, 287]] 1.0 9q32 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus DFGAsp-rot-in -121.61, 171.92 -133.79, 66.08 177.88, 26.12 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus DFGAsp-rot-in -118.21, 174.22 -136.13, 64.53 181.1, 28.93 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY8A Q13546 8 294 671.0 A1IX7:301 Type3 Inactive DFGout 12.981 9.596 BBAminus DFGAsp-rot-in -141.13, 164.94 -130.11, 66.18 182.31, 35.61 -66.58, -24.49 309.73, 7.18 -84.28, -2.51 out-out out 14.033 Saltbr-out 11.772 HRD-out -86.53, 114.22 -72.4, -38.91 out-out-out SNCooo out-out ActLoopNT-out 6.11 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.03 APE8-dihe-out -67.08, -34.07 APE8-rot-out 196.53 APE67-dihe-in -68.73, -30.32 -60.21, -30.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.808 None None None XRAY 2.98 0.23 0.295 A 297 260 27 0 0 18 [[17, 287]] 1.0 9hy8 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY8B Q13546 7 294 671.0 1HX:305 Type3 Inactive DFGout 13.904 9.078 BBAminus DFGAsp-rot-in -137.15, 163.21 -126.56, 62.14 181.49, 37.0 -66.56, -24.08 304.02, 3.22 -81.88, 1.19 out-out out 13.745 Saltbr-out 12.321 HRD-out -85.29, 111.77 -72.25, -38.63 out-out-out SNCooo out-out ActLoopNT-out 6.114 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -35.46 APE8-rot-out 195.34 APE67-dihe-in -63.95, -33.12 -61.2, -31.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.98 0.23 0.295 B 297 271 17 0 0 12 [[17, 287]] 1.0 9hy8 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY9A Q13546 10 294 671.0 A1IX9:301 Type3 Inactive DFGout 12.864 9.725 BBAminus DFGAsp-rot-in -132.24, 163.44 -119.98, 69.92 175.12, 34.62 -71.64, -30.92 302.3, 2.93 -73.75, -3.09 out-out out 14.314 Saltbr-out 11.313 HRD-in -66.75, -56.07 86.01, -13.31 out-out-out SNCooo out-out ActLoopNT-out 6.04 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -51.61 APE8-dihe-out -64.18, -21.53 APE8-rot-out 61.29 APE67-dihe-in -61.96, -24.09 -103.08, -2.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.198 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 A 297 251 34 0 0 18 [[17, 287]] 1.0 9hy9 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9HY9B Q13546 8 294 671.0 A1IX9:301 Type3 Inactive DFGout 14.034 9.477 BBAminus DFGAsp-rot-in -133.17, 165.69 -124.95, 70.39 172.81, 33.44 -65.88, -32.58 304.79, 2.82 -81.7, 4.58 out-out out 14.395 Saltbr-out 11.494 HRD-in -67.55, -54.35 91.32, -11.86 out-out-out SNCooo out-out ActLoopNT-out 6.175 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.85 APE8-dihe-in -57.79, 140.57 APE8-rot-out 188.52 APE67-dihe-in -62.67, -21.78 -100.89, 3.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.311 C34A,C127A,C233A,C240A None None XRAY 2.29 0.219 0.275 B 297 265 22 0 0 13 [[17, 287]] 1.0 9hy9 Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DA Q13546 8 294 671.0 EJP:1100 Type3 Inactive DFGout 15.126 10.11 BBAminus DFGAsp-rot-in -117.56, 178.71 -149.43, 73.24 186.48, 32.2 -69.95, -18.38 305.75, 179.55 -101.55, 7.83 out-out out 16.257 Saltbr-out 16.566 HRD-in -55.77, -51.03 80.27, -34.22 out-out-out SNCooo out-out ActLoopNT-out 5.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.93 APE8-dihe-in -106.53, 126.83 APE8-rot-in 321.17 APE67-dihe-in -67.47, -17.91 -88.44, 5.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.641 None None None XRAY 2.52 0.246 0.296 A 297 267 20 0 0 13 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DB Q13546 7 294 671.0 EJP:1100 Type3 Inactive DFGout 14.902 9.997 BBAminus DFGAsp-rot-in -109.17, 170.78 -134.96, 67.82 191.15, 62.76 -67.04, -23.45 302.04, 179.31 -86.78, -0.45 out-out out 13.971 Saltbr-out 13.274 HRD-in -58.83, -55.33 81.23, -6.46 out-out-out SNCooo out-out ActLoopNT-out 6.208 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 135.34 APE8-dihe-in -76.56, 126.03 APE8-rot-in 339.29 APE67-dihe-in -57.69, -33.16 -79.19, -15.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.114 None None None XRAY 2.52 0.246 0.296 B 297 266 22 0 0 16 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DC Q13546 10 294 671.0 EJP:1100 Type3 Inactive DFGout 13.888 9.719 BBAminus DFGAsp-rot-in -117.68, 178.27 -141.12, 66.69 187.08, 29.32 -63.91, -32.83 304.36, 1.77 -82.22, -7.01 out-out out 14.002 Saltbr-out 13.724 HRD-out -79.05, 115.27 -95.69, 8.59 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.35 APE8-dihe-in -80.27, 139.4 APE8-rot-in 352.11 APE67-dihe-in -58.83, -30.61 -90.66, -17.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.716 None None None XRAY 2.52 0.246 0.296 C 297 258 27 0 0 18 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6C4DD Q13546 5 293 671.0 EJP:1100 Type3 Inactive DFGout 14.579 10.057 BBAminus DFGAsp-rot-in -117.58, 172.01 -139.03, 81.37 191.71, 1.36 -72.34, -39.58 302.56, 173.11 -76.31, -0.83 out-out out 15.418 Saltbr-out 15.949 HRD-out -76.11, 120.54 -93.07, -33.93 out-out-out SNCooo out-out ActLoopNT-out 5.708 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.51 APE8-dihe-in -75.78, 153.21 APE8-rot-out 63.53 APE67-dihe-in -63.87, -30.91 -109.82, 5.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.301 None None None XRAY 2.52 0.246 0.296 D 297 266 23 0 0 16 [[17, 287]] 1.0 6c4d Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 5HX6A Q13546 10 294 671.0 65U:301 Type3 Inactive DFGout 13.746 10.081 BBAminus DFGAsp-rot-in -114.15, 174.66 -134.73, 71.48 191.79, 44.33 -75.96, -22.44 306.17, 175.84 -90.96, 8.33 out-out out 15.167 Saltbr-out 14.396 HRD-in -69.31, -54.37 72.33, -26.98 out-out-out SNCooo out-out ActLoopNT-out 5.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.42 APE8-dihe-in -113.81, 128.35 APE8-rot-in 307.51 APE67-dihe-in -68.28, -25.41 -91.99, -10.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.926 C34A,C127A,C233A,C240A None None XRAY 2.23 0.202 0.248 A 303 259 26 0 0 18 [[17, 287]] 1.0 5hx6 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 5TX5A Q13546 10 294 671.0 7MJ:301 Type3 Inactive DFGout 13.573 10.201 BBAminus DFGAsp-rot-in -116.16, 171.57 -130.87, 63.14 191.27, 66.76 -69.82, -14.33 312.94, 168.86 -98.42, 6.27 out-out out 14.845 Saltbr-out 14.379 HRD-in -66.81, -51.24 62.33, -1.21 out-out-out SNCooo out-out ActLoopNT-out 6.13 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.73 APE8-dihe-in -110.36, 127.1 APE8-rot-in 310.57 APE67-dihe-in -70.3, -28.6 -100.12, 4.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.291 C34A,C127A,C233A,C240A None None XRAY 2.56 0.2 0.24 A 303 259 26 0 0 18 [[17, 287]] 1.0 5tx5 Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6HHOA Q13546 8 294 671.0 G4W:301 Type3 Inactive DFGout 13.67 9.694 BBAminus DFGAsp-rot-in -115.24, 164.48 -126.66, 62.71 179.85, 55.23 -63.79, -26.65 296.63, 179.45 -87.49, 3.26 out-out out 14.208 Saltbr-out 13.017 HRD-in -59.4, -57.1 78.79, -22.09 out-out-out SNCooo out-out ActLoopNT-out 6.209 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 174.3 APE8-dihe-in -93.04, 144.83 APE8-rot-out 195.71 APE67-dihe-in -65.11, -26.33 -104.41, -2.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.244 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 A 303 273 14 0 0 11 [[17, 287]] 1.0 6hho Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6HHOB Q13546 7 294 671.0 G4W:301 Type3 Inactive DFGout 13.824 9.442 BBAminus DFGAsp-rot-in -119.74, 167.8 -136.07, 70.92 169.95, -84.84 -69.13, -25.22 303.5, 11.26 -79.53, -4.81 out-out out 14.318 Saltbr-out 12.609 HRD-in -55.52, -56.34 83.4, -19.29 out-out-none SNCoon out-none ActLoopNT-out 6.05 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -34.12 APE8-rot-in 325.58 APE67-dihe-in -55.64, -31.82 -55.9, -39.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.49 0.209 0.227 B 303 266 22 0 0 12 [[17, 287]] 1.0 6hho Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6OCQB Q13546 7 294 671.0 M5J:301 Type3 Inactive DFGout 13.012 8.057 BBAminus DFGAsp-rot-in -130.11, 162.38 -122.52, 81.31 185.37, -5.83 -82.7, -15.44 293.68, 160.97 -87.37, 2.43 out-out out 13.636 Saltbr-out 13.611 HRD-in -64.49, -53.65 73.55, -4.84 out-out-out SNCooo out-out ActLoopNT-out 5.464 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-out 173.0 APE67-dihe-in -61.59, -15.49 -61.5, -24.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 2.793 0.206 0.268 B 303 274 14 0 0 12 [[17, 287]] 1.0 6ocq Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FA Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.955 9.481 BBAminus DFGAsp-rot-in -112.95, 165.41 -130.42, 63.72 180.08, 54.56 -66.93, -21.93 297.24, 0.02 -91.89, 5.73 out-out out 14.529 Saltbr-out 13.191 HRD-in -56.51, -60.39 80.9, -22.8 out-out-out SNCooo out-out ActLoopNT-out 5.924 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.38 APE8-rot-out 178.71 APE67-dihe-in -64.62, -25.33 -74.5, -6.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 A 303 252 34 0 0 16 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FB Q13546 10 294 671.0 JSW:301 Type3 Inactive DFGout 13.78 9.691 BBAminus DFGAsp-rot-in -117.91, 170.03 -135.39, 68.26 176.51, 38.79 -70.88, -17.07 303.86, 8.01 -86.89, -7.53 out-out out 14.147 Saltbr-out 14.183 HRD-in -58.11, -56.03 90.31, -47.38 out-out-out SNCooo out-out ActLoopNT-out 6.22 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.8 APE8-dihe-in -110.24, 128.64 APE8-rot-out 54.88 APE67-dihe-in -53.24, -34.36 -61.38, -32.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.919 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 B 303 256 29 0 0 17 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FC Q13546 9 294 671.0 JSW:301 Type3 Inactive DFGout 13.993 9.934 BBAminus DFGAsp-rot-in -129.98, 154.77 -113.58, 87.15 188.59, -5.78 -77.89, -25.03 313.32, 1.4 -85.25, 0.11 out-out out 14.529 Saltbr-out 15.039 HRD-in -68.31, -36.48 72.06, -57.73 out-out-out SNCooo out-out ActLoopNT-out 5.739 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.85 APE8-dihe-in -109.8, 132.44 APE8-rot-out 61.03 APE67-dihe-in -41.51, -34.43 -97.85, -8.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.153 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 C 303 253 33 0 0 16 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6R5FD Q13546 11 294 671.0 JSW:301 Type3 Inactive DFGout 14.45 9.248 BBAminus DFGAsp-rot-in -142.39, 170.94 -125.26, 78.91 214.02, -13.58 -70.36, -35.3 283.29, 144.33 -66.46, -23.13 out-out out 15.019 Saltbr-out 16.123 HRD-in -59.61, -37.57 70.15, -52.85 out-out-out SNCooo out-out ActLoopNT-out 6.06 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 119.22 APE8-dihe-in -103.39, 137.53 APE8-rot-out 189.96 APE67-dihe-in -50.68, -36.72 -90.03, -10.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.433 C34A,C127A,C233A,C240A None None XRAY 3.25 0.245 0.289 D 303 250 34 0 0 17 [[17, 287]] 1.0 6r5f Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6RLNA Q13546 8 294 671.0 K8K:301 Type3 Inactive DFGout 13.828 9.344 BBAminus DFGAsp-rot-in -121.93, 164.11 -127.72, 59.44 180.68, 46.74 -57.14, -30.4 302.07, 177.27 -86.63, -0.56 out-out out 14.464 Saltbr-out 13.169 HRD-in -55.19, -50.82 78.22, -37.5 out-out-out SNCooo out-out ActLoopNT-out 5.952 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.07 APE8-dihe-in -87.79, 130.01 APE8-rot-in 299.1 APE67-dihe-in -57.83, -39.09 -99.26, -10.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.716 C34A,C127A,C233A,C240A None None XRAY 2.87 0.196 0.232 A 303 266 21 0 0 11 [[17, 287]] 1.0 6rln Homo sapiens TKL_RIPK1_HUMAN TKL 1.4e-72 250.4 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NW2A Q13546 8 294 671.0 L4Y:301 Type3 Inactive DFGout 13.608 9.512 BBAminus DFGAsp-rot-in -126.76, 173.12 -134.47, 72.41 174.44, 34.45 -77.05, -17.16 300.87, 12.85 -87.44, 3.81 out-out out 13.794 Saltbr-out 12.048 HRD-in -68.25, -50.83 78.22, -14.78 out-out-none SNCoon out-none ActLoopNT-out 6.312 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.64 APE8-rot-in 298.28 APE67-dihe-in -63.58, -21.18 -59.6, -37.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.212 0.261 A 310 260 27 0 0 12 [[17, 287]] 1.0 6nw2 Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 6NW2B Q13546 11 294 671.0 L4Y:301 Type3 Inactive DFGout 13.716 9.993 BBAminus DFGAsp-rot-in -122.99, 177.91 -138.58, 64.6 180.05, 18.31 -73.14, -19.26 303.52, 11.16 -82.07, -0.78 out-out out 14.265 Saltbr-out 13.612 HRD-in -71.79, -51.87 81.67, -16.37 out-out-out SNCooo out-out ActLoopNT-out 6.279 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -16.93 APE8-dihe-out -77.38, -12.49 APE8-rot-out 198.5 APE67-dihe-in -68.62, -19.61 -107.28, 7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.491 None None None XRAY 2.0 0.212 0.261 B 310 246 38 0 0 18 [[17, 287]] 1.0 6nw2 Homo sapiens TKL_RIPK1_HUMAN TKL 1.5e-72 250.3 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 9GTYA Q13546 8 294 671.0 RCM:301 Type3 Inactive DFGout 13.983 8.222 BBAminus DFGAsp-rot-in -123.34, 171.31 -137.95, 64.52 176.69, 29.45 -61.74, -25.38 305.36, 176.3 -90.28, 0.66 out-out out 13.752 Saltbr-out 13.245 HRD-in -64.08, -57.67 81.97, -22.12 out-out-out SNCooo out-out ActLoopNT-out 5.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -14.17 APE8-dihe-out -79.25, -21.69 APE8-rot-out 51.22 APE67-dihe-in -62.86, -31.23 -89.57, 1.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.816 C34A,C127A,C233A,C240A None None XRAY 2.145 0.251 0.294 A 313 253 34 0 0 19 [[17, 287]] 1.0 9gty Homo sapiens TKL_RIPK1_HUMAN TKL 1.6e-72 250.2 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TYR ABL1 ABL1_HUMAN 3QRKA P00519 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.538 9.263 BBAminus DFGAsp-rot-in -128.74, -174.73 -147.03, 106.14 178.14, -8.71 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.853 Saltbr-in 2.674 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.303 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.815 APE11-dist-na 15.758 APE10-dist-na 10.991 APE9-dist-na 7.585 None None None XRAY 2.3 0.192 0.281 A 277 268 0 0 0 0 [[242, 495]] 1.0 3qrk Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR DDR1 DDR1_HUMAN 7FEHA Q08345 603 912 913.0 3UI:1001 Type3 Inactive DFGout 14.614 10.976 BBAminus DFGAsp-rot-in -140.43, -166.19 -155.59, 100.98 183.75, -8.06 -76.78, -5.55 282.16, 80.98 68.97, 34.94 in-in in 8.239 Saltbr-in 2.707 HRD-in -73.62, -47.42 78.59, -7.41 in-out-in SNCioi out-in ActLoopNT-out 18.36 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.1, 130.52 APE9-dihe-in -126.17, 127.16 APE8-dihe-in -82.15, 70.85 APE8-rot-na 34.51 APE67-dihe-in -74.2, -7.26 -55.53, -34.86 APE12-dist-na 14.424 APE11-dist-na 11.384 APE10-dist-na 6.966 APE9-dist-na 7.347 None None None XRAY 1.61 0.168 0.206 A 320 293 11 0 0 0 [[610, 907]] 1.0 7feh Homo sapiens TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5BVKA Q08345 604 911 913.0 4VC:1007 Type3 Inactive DFGout 12.534 10.223 None DFGAsp-rot-in -129.55, -176.3 -140.67, 98.58 194.41, 10.77 -92.44, 131.08 301.57, 107.64 -55.47, -44.27 in-in in 8.231 Saltbr-in 2.779 HRD-in -71.41, -52.83 83.7, -18.63 in-out-in SNCioi out-in ActLoopNT-out 15.725 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -83.83, 116.31 APE9-dihe-in -112.39, 120.52 APE8-dihe-in -71.84, 64.33 APE8-rot-na 29.08 APE67-dihe-in -73.09, -12.57 -54.87, -32.03 APE12-dist-na 18.806 APE11-dist-na 15.611 APE10-dist-na 11.342 APE9-dist-na 7.263 None None None XRAY 2.29 0.19 0.232 A 324 278 30 0 0 0 [[610, 907]] 1.0 5bvk Homo sapiens TYR_DDR1_HUMAN TYR 1.7e-92 315.4 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 8A27A P00533 701 985 1210.0 KY9:1102 Type3 Inactive DFGin 5.672 14.381 BLAplus DFGAsp-rot-out -145.52, -178.77 57.22, 42.47 287.34, -1.9 -100.42, -1.68 47.88, 94.3 -89.32, 20.08 out-out out 13.238 Saltbr-out 11.714 HRD-in -70.42, -54.97 75.01, -8.44 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.04 APE8-dihe-in -81.29, 59.61 APE8-rot-na 35.43 APE67-dihe-in -73.27, -7.01 -50.89, -40.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.484 None None None XRAY 1.07 0.126 0.16 A 326 269 16 0 0 16 [[712, 970]] 1.0 8a27 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2AA P00533 700 1019 1210.0 KY9:1101 Type3 Inactive DFGin 5.117 14.356 BLAplus DFGAsp-rot-out -139.34, 175.57 57.42, 45.45 286.02, -2.31 -97.33, -2.42 49.8, 85.36 -104.26, 24.72 out-out out 13.637 Saltbr-out 12.255 HRD-in -68.19, -54.53 72.52, -7.02 out-out-none SNCoon out-none ActLoopNT-out 6.62 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.68 APE8-dihe-in -79.56, 62.59 APE8-rot-na 33.47 APE67-dihe-in -77.17, -2.3 -52.5, -40.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.037 None None None XRAY 1.43 0.19 0.223 A 326 306 8 0 0 8 [[712, 970]] 1.0 8a2a Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2DA P00533 701 1021 1210.0 KXY:1103 Type3 Inactive DFGin 6.285 15.539 BLBminus DFGAsp-rot-out -141.89, -177.21 45.57, 75.85 289.49, -7.72 -58.33, 149.05 294.71, 179.21 -62.78, 135.74 out-out out 13.017 Saltbr-out 10.523 HRD-in -72.83, -53.94 77.64, -5.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.3 APE8-dihe-in -76.96, 68.89 APE8-rot-na 35.24 APE67-dihe-in -71.59, -9.31 -48.88, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.169 L858R,V948R None None XRAY 1.11 0.164 0.179 A 326 281 10 0 0 10 [[712, 970]] 1.0 8a2d Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5ZWJA P00533 702 985 1210.0 9LL:1101 Type3 Inactive DFGin 5.542 14.462 BLBplus DFGAsp-rot-out -134.76, 169.78 70.33, 21.35 292.87, -5.43 -80.26, 157.71 46.02, 86.11 85.63, 6.58 out-none out 12.365 Saltbr-none 999.0 HRD-in -62.57, -46.38 74.18, -0.41 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.69 APE8-dihe-in -84.81, 75.57 APE8-rot-na 34.77 APE67-dihe-in -62.54, -42.94 -62.02, -41.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.058 T790M,C797S,V948R None None XRAY 2.9 0.256 0.272 A 355 267 17 0 0 17 [[712, 970]] 1.0 5zwj Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8A2BA P00533 702 990 1210.0 KY9:1101 Type3 Inactive DFGin 5.426 14.435 BLBplus DFGAsp-rot-out -143.53, -174.33 44.34, 37.79 305.95, -21.04 -92.75, 167.36 44.38, 91.12 110.41, -145.91 out-out out 13.246 Saltbr-out 12.26 HRD-in -75.49, -60.69 77.7, -7.21 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.84 APE8-dihe-in -84.13, 67.89 APE8-rot-na 33.21 APE67-dihe-in -76.37, -2.66 -52.66, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.066 L858R,V948R None None XRAY 1.69 0.212 0.258 A 326 272 17 0 0 17 [[712, 970]] 1.0 8a2b Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR ITK ITK_HUMAN 4M12A Q08881 355 618 620.0 1YZ:701 Type3 Inactive DFGin 7.901 15.256 BLBplus DFGAsp-rot-out -141.2, 169.8 60.4, 25.89 302.78, -1.84 -67.61, 137.8 36.63, 92.49 68.92, 0.26 out-out out 17.153 Saltbr-out 16.924 HRD-in -66.63, -51.27 84.1, -22.7 out-out-out SNCooo out-out ActLoopNT-out 7.86 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.29, 13.09 APE9-dihe-in -55.02, 125.4 APE8-dihe-in -69.29, 63.1 APE8-rot-na 28.21 APE67-dihe-in -55.35, -27.28 -53.96, -32.74 APE12-dist-na 16.702 APE11-dist-na 19.4 APE10-dist-na 14.954 APE9-dist-na 9.292 None None None XRAY 2.15 0.185 0.228 A 269 264 0 0 0 0 [[363, 614]] 1.0 4m12 Homo sapiens TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR ITK ITK_HUMAN 4M13A Q08881 355 618 620.0 1E0:701 Type3 Inactive DFGin 7.937 15.236 BLBplus DFGAsp-rot-out -140.0, 164.92 66.92, 22.84 301.09, -7.35 -65.43, 134.74 36.83, 90.87 73.53, -6.2 out-out out 17.258 Saltbr-out 17.152 HRD-in -67.22, -57.57 90.49, -24.24 out-out-out SNCooo out-out ActLoopNT-out 7.795 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.18, 13.19 APE9-dihe-in -58.29, 129.4 APE8-dihe-in -71.46, 60.73 APE8-rot-na 27.96 APE67-dihe-in -58.06, -25.43 -56.35, -32.28 APE12-dist-na 16.675 APE11-dist-na 19.459 APE10-dist-na 14.985 APE9-dist-na 9.271 None None None XRAY 1.85 0.19 0.232 A 269 264 0 0 0 0 [[363, 614]] 1.0 4m13 Homo sapiens TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR MERTK MERTK_HUMAN 7AW4A Q12866 576 862 999.0 S5E:901 Type3 Inactive DFGout 14.166 6.988 BBAminus DFGAsp-rot-in -151.73, 174.5 -134.58, 93.64 199.28, -45.36 -99.75, 11.14 282.83, 106.8 -60.06, 134.62 out-out out 12.678 Saltbr-out 6.924 HRD-in -71.68, -56.26 76.66, -5.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.4 APE8-rot-na 27.32 APE67-dihe-in -72.74, -3.62 -49.0, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.98 0.215 0.246 A 313 264 23 0 0 17 [[587, 856]] 1.0 7aw4 Homo sapiens TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW4B Q12866 574 862 999.0 S5E:901 Type3 Inactive DFGout 14.17 7.002 BBAminus DFGAsp-rot-in -152.39, 174.35 -134.62, 92.94 199.68, -46.03 -100.47, 8.02 282.22, 107.21 -60.15, 130.28 out-out out 12.756 Saltbr-out 7.104 HRD-in -72.36, -56.01 76.07, -4.93 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.48 APE8-rot-na 27.51 APE67-dihe-in -72.81, -3.1 -48.72, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.98 0.215 0.246 B 313 257 32 0 0 18 [[587, 856]] 1.0 7aw4 Homo sapiens TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 8OUUA P08581 1059 1346 1390.0 W49:1404 Type3 Inactive DFGout 13.515 6.876 BBAminus DFGAsp-rot-in -147.46, -168.73 -151.04, 108.81 190.89, -19.36 -112.08, 40.61 288.5, 94.51 -110.14, -161.37 out-out out 12.355 Saltbr-out 10.46 HRD-in -63.12, -55.99 76.4, -17.82 out-out-in SNCooi out-in ActLoopNT-out 9.091 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -82.11, 150.07 APE9-dihe-in -72.2, 149.25 APE8-dihe-in -80.89, 58.5 APE8-rot-na 27.43 APE67-dihe-in -74.53, -1.63 -44.12, -49.33 APE12-dist-na 999.0 APE11-dist-na 6.546 APE10-dist-na 10.792 APE9-dist-na 7.893 D1228V None None XRAY 1.77 0.203 0.225 A 309 284 4 0 0 4 [[1078, 1339]] 1.0 8ouu Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUUB P08581 1057 1346 1390.0 W49:1405 Type3 Inactive DFGout 13.488 6.97 BBAminus DFGAsp-rot-in -144.89, -171.19 -149.83, 102.26 193.02, -21.79 -101.8, 30.99 273.18, 101.18 -108.36, -152.3 out-out out 12.311 Saltbr-out 10.383 HRD-in -62.48, -51.05 73.17, -16.23 out-out-in SNCooi out-in ActLoopNT-out 9.188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -63.11, 139.96 APE9-dihe-in -71.28, 138.06 APE8-dihe-in -78.82, 59.01 APE8-rot-na 36.37 APE67-dihe-in -74.44, -3.9 -45.73, -43.18 APE12-dist-na 10.634 APE11-dist-na 6.56 APE10-dist-na 11.61 APE9-dist-na 8.235 D1228V None None XRAY 1.77 0.203 0.225 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ouu Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUVA P08581 1053 1346 1390.0 W3R:1401 Type3 Inactive DFGout 13.432 6.982 BBAminus DFGAsp-rot-in -150.55, -166.67 -153.94, 107.37 184.46, -3.47 -108.14, 42.08 281.33, 84.2 -114.79, -152.59 out-out out 12.492 Saltbr-out 10.788 HRD-in -65.45, -52.15 77.68, -39.15 out-out-in SNCooi out-in ActLoopNT-out 9.594 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.07, 137.88 APE9-dihe-in -75.04, 140.45 APE8-dihe-in -83.02, 58.2 APE8-rot-na 29.39 APE67-dihe-in -74.39, -2.19 -46.6, -48.03 APE12-dist-na 10.641 APE11-dist-na 6.116 APE10-dist-na 10.331 APE9-dist-na 8.21 D1228V None None XRAY 1.783 0.193 0.22 A 309 294 0 0 0 0 [[1078, 1339]] 1.0 8ouv Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OUVB P08581 1057 1346 1390.0 W3R:1403 Type3 Inactive DFGout 13.51 7.147 BBAminus DFGAsp-rot-in -147.83, -171.85 -148.7, 102.33 190.45, -21.29 -101.0, 36.34 274.67, 80.19 -118.46, -149.43 out-out out 12.359 Saltbr-out 10.666 HRD-in -65.36, -51.5 76.95, -23.29 out-out-in SNCooi out-in ActLoopNT-out 9.126 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.24, 136.99 APE9-dihe-in -67.7, 139.76 APE8-dihe-in -82.33, 58.02 APE8-rot-na 32.55 APE67-dihe-in -77.97, -2.31 -52.96, -31.41 APE12-dist-na 10.989 APE11-dist-na 6.865 APE10-dist-na 11.983 APE9-dist-na 8.293 D1228V None None XRAY 1.783 0.193 0.22 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ouv Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OV7A P08581 1051 1346 1390.0 W3W:1401 Type3 Inactive DFGout 16.903 9.364 BBAminus DFGAsp-rot-in -153.61, -165.39 -151.4, 119.76 182.24, 19.38 -84.83, -13.59 281.18, 90.67 -96.35, -144.67 out-out out 12.327 Saltbr-out 10.74 HRD-in -65.11, -52.02 80.74, -20.69 out-out-out SNCooo out-out ActLoopNT-out 6.49 ActLoopCT-out TYR APEdihe_iioai APEdist_aaaa APE10-dihe-in -77.6, 93.42 APE9-dihe-in -116.32, 89.67 APE8-dihe-out -52.96, -30.95 APE8-rot-na 334.19 APE67-dihe-in -78.41, -2.44 -56.72, -27.38 APE12-dist-na 16.993 APE11-dist-na 17.033 APE10-dist-na 11.812 APE9-dist-na 10.786 D1228V None None XRAY 1.95 0.274 0.287 A 309 289 7 0 0 0 [[1078, 1339]] 1.0 8ov7 Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OVZA P08581 1061 1346 1390.0 W3N:1411 Type3 Inactive DFGout 13.353 7.006 BBAminus DFGAsp-rot-in -146.53, -171.32 -145.54, 124.96 177.55, -83.35 -119.17, 42.96 279.31, 88.35 -118.39, -154.9 out-out out 12.132 Saltbr-out 11.597 HRD-in -61.66, -54.56 76.63, -30.67 out-out-in SNCooi out-in ActLoopNT-out 9.29 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -75.2, 144.98 APE9-dihe-in -69.5, 147.31 APE8-dihe-in -82.74, 56.17 APE8-rot-na 31.37 APE67-dihe-in -67.83, -2.09 -44.04, -52.84 APE12-dist-na 10.733 APE11-dist-na 6.553 APE10-dist-na 11.677 APE9-dist-na 8.152 D1228V None None XRAY 2.206 0.227 0.275 A 309 286 0 0 0 0 [[1078, 1339]] 1.0 8ovz Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OVZB P08581 1057 1346 1390.0 W3N:1410 Type3 Inactive DFGout 13.772 6.771 BBAminus DFGAsp-rot-in -146.01, -169.05 -148.05, 116.27 204.18, -49.13 -112.98, 47.33 264.21, 88.29 -128.7, -142.69 out-out out 12.232 Saltbr-out 11.019 HRD-in -68.15, -51.01 72.21, -18.47 out-out-in SNCooi out-in ActLoopNT-out 9.007 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.33, 137.86 APE9-dihe-in -70.76, 127.71 APE8-dihe-in -79.23, 64.44 APE8-rot-na 29.84 APE67-dihe-in -76.38, -8.07 -54.71, -26.75 APE12-dist-na 10.89 APE11-dist-na 6.759 APE10-dist-na 11.936 APE9-dist-na 8.433 D1228V None None XRAY 2.206 0.227 0.275 B 309 290 0 0 0 0 [[1078, 1339]] 1.0 8ovz Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGA P08581 1060 1344 1390.0 W40:1401 Type3 Inactive DFGout 15.215 7.185 BBAminus DFGAsp-rot-in -151.69, 176.81 -129.27, 111.57 197.85, -20.24 -101.99, 63.08 247.0, 19.93 135.49, 100.91 out-none out 12.564 Saltbr-none 999.0 HRD-in -54.29, -59.14 87.34, -18.08 none-out-none SNCnon out-none ActLoopNT-out 6.455 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 39.54 APE8-rot-na 32.71 APE67-dihe-in -69.3, -0.31 -58.16, -36.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D1228V None None XRAY 2.631 0.283 0.329 A 309 244 41 0 0 17 [[1078, 1339]] 1.0 8owg Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGB P08581 1060 1343 1390.0 W40:1401 Type3 Inactive DFGout 13.474 7.027 BBAminus DFGAsp-rot-in -143.52, -173.91 -145.15, 96.11 200.22, -29.73 -104.84, 19.11 287.04, 87.7 -144.89, 36.92 out-none out 12.676 Saltbr-none 999.0 HRD-in -57.0, -54.53 71.26, 2.24 none-out-in SNCnoi out-in ActLoopNT-out 8.803 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.21, 155.54 APE9-dihe-in -138.84, 156.19 APE8-dihe-in -90.42, 73.4 APE8-rot-na 26.27 APE67-dihe-in -74.77, 0.81 -53.95, -37.48 APE12-dist-na 13.969 APE11-dist-na 10.934 APE10-dist-na 9.933 APE9-dist-na 7.283 D1228V None None XRAY 2.631 0.283 0.329 B 309 246 38 0 0 14 [[1078, 1339]] 1.0 8owg Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OWGC P08581 1060 1343 1390.0 W40:1401 Type3 Inactive DFGout 13.494 7.396 BBAminus DFGAsp-rot-in -137.63, 176.74 -129.85, 94.81 212.98, -42.17 -103.25, 51.6 272.59, 87.18 162.66, 999.0 out-none out 12.719 Saltbr-none 999.0 HRD-in -60.14, -44.34 69.98, -16.33 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.95 APE8-dihe-in -84.26, 62.47 APE8-rot-na 30.42 APE67-dihe-in -68.37, 4.72 -58.51, -48.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.132 D1228V None None XRAY 2.631 0.283 0.329 C 309 235 49 0 0 20 [[1078, 1339]] 1.0 8owg Homo sapiens TYR_MET_HUMAN TYR 1.6e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8OW3A P08581 1058 1345 1390.0 W40:1401 Type3 Inactive DFGout 13.282 6.949 BBAminus DFGAsp-rot-in -144.85, -172.89 -148.19, 116.28 194.24, -22.83 -124.16, 31.55 280.56, 89.39 -106.2, 999.0 out-none out 12.663 Saltbr-none 999.0 HRD-in -58.32, -54.99 72.45, -5.24 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.74 APE8-dihe-in -87.02, 65.42 APE8-rot-na 27.11 APE67-dihe-in -76.81, 1.52 -53.65, -34.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.743 None None None XRAY 2.27 0.247 0.295 A 309 258 30 0 0 20 [[1078, 1339]] 1.0 8ow3 Homo sapiens TYR_MET_HUMAN TYR 7.1e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PL4A P04629 485 795 796.0 OO7:801 Type3 Inactive DFGout 12.331 6.751 BBAminus DFGAsp-rot-out 163.32, 156.14 -161.4, 166.2 68.92, 89.64 -103.41, 14.03 294.82, 105.0 75.38, 27.87 in-out in 9.548 Saltbr-out 6.947 HRD-in -67.83, -53.77 81.67, -11.19 out-out-in SNCooi out-in ActLoopNT-out 15.677 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.06, 119.89 APE9-dihe-in -108.16, 133.15 APE8-dihe-in -81.07, 64.06 APE8-rot-na 35.11 APE67-dihe-in -63.69, -22.36 -54.01, -37.98 APE12-dist-na 13.774 APE11-dist-na 15.065 APE10-dist-na 10.803 APE9-dist-na 7.259 None SEP677 SEP677 XRAY 2.06 0.202 0.239 A 311 299 3 0 0 0 [[510, 783]] 1.0 6pl4 Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSPA P04629 500 795 796.0 L0P:801 Type3 Inactive DFGout 12.341 6.918 None DFGAsp-rot-out 147.69, 153.73 -147.15, -178.06 57.89, 82.36 -113.86, 11.77 292.26, 110.9 67.54, 37.24 in-out in 9.506 Saltbr-out 9.102 HRD-in -80.74, -60.67 84.66, -17.32 out-out-in SNCooi out-in ActLoopNT-out 15.69 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -135.01, 112.02 APE9-dihe-in -104.87, 129.45 APE8-dihe-in -77.35, 65.98 APE8-rot-na 35.66 APE67-dihe-in -61.95, -17.33 -58.27, -39.42 APE12-dist-na 13.388 APE11-dist-na 15.055 APE10-dist-na 10.661 APE9-dist-na 7.371 None None None XRAY 2.31 0.192 0.255 A 297 293 3 0 0 0 [[510, 783]] 1.0 6nsp Homo sapiens TYR_NTRK1_HUMAN TYR 1.8e-100 341.5 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NPTA P04629 491 795 796.0 KWY:801 Type3 Inactive DFGout 12.438 7.501 None DFGAsp-rot-out 158.18, 155.8 -152.05, 169.87 66.59, 77.8 -107.1, 19.78 311.07, 121.3 72.87, 27.1 out-out out 10.008 Saltbr-out 5.238 HRD-in -70.4, -52.75 80.08, -14.8 out-out-in SNCooi out-in ActLoopNT-out 15.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -127.83, 113.75 APE9-dihe-in -105.63, 131.16 APE8-dihe-in -80.28, 65.31 APE8-rot-na 34.86 APE67-dihe-in -61.58, -17.65 -56.43, -41.31 APE12-dist-na 14.426 APE11-dist-na 15.187 APE10-dist-na 10.648 APE9-dist-na 7.262 None SEP677 SEP677 XRAY 2.19 0.227 0.276 A 305 288 10 0 0 0 [[510, 783]] 1.0 6npt Homo sapiens TYR_NTRK1_HUMAN TYR 2e-100 341.4 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSSA P04629 485 795 796.0 L0M:801 Type3 Inactive DFGout 11.815 7.025 None DFGAsp-rot-out 168.65, 153.78 -158.36, 171.84 65.15, 78.36 -109.19, 24.3 297.57, 118.56 67.82, 28.96 in-out in 9.528 Saltbr-out 5.666 HRD-in -90.15, -59.03 81.79, -5.07 out-out-in SNCooi out-in ActLoopNT-out 16.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -142.54, 111.04 APE9-dihe-in -105.46, 130.52 APE8-dihe-in -80.81, 65.09 APE8-rot-na 33.3 APE67-dihe-in -66.94, -20.44 -58.3, -34.71 APE12-dist-na 13.068 APE11-dist-na 15.018 APE10-dist-na 10.687 APE9-dist-na 7.449 None None None XRAY 1.97 0.184 0.218 A 311 303 3 0 0 0 [[510, 783]] 1.0 6nss Homo sapiens TYR_NTRK1_HUMAN TYR 2.1e-100 341.3 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6D1YA P04629 481 796 796.0 FQJ:801 Type3 Inactive DFGout 12.673 6.856 None DFGAsp-rot-out 169.8, 145.64 -149.42, -179.74 67.03, 86.72 -114.54, 6.91 301.35, 101.16 76.21, 25.01 out-out out 10.052 Saltbr-out 5.442 HRD-in -65.07, -51.13 81.32, -20.97 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -101.27, 120.93 APE9-dihe-in -115.22, 138.24 APE8-dihe-in -78.51, 63.15 APE8-rot-na 29.74 APE67-dihe-in -66.08, -21.72 -48.21, -36.42 APE12-dist-na 999.0 APE11-dist-na 14.923 APE10-dist-na 10.709 APE9-dist-na 7.254 None None None XRAY 1.93 0.179 0.224 A 320 300 16 0 0 4 [[510, 783]] 1.0 6d1y Homo sapiens TYR_NTRK1_HUMAN TYR 2.3e-100 341.2 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMIA P04629 486 796 796.0 6UE:901 Type3 Inactive DFGout 12.102 7.293 None DFGAsp-rot-out 161.69, 152.83 -154.44, 168.25 64.92, -83.35 -105.96, 25.99 305.3, 125.58 65.11, 30.06 in-out in 9.486 Saltbr-out 6.201 HRD-in -70.33, -55.53 75.77, -9.09 out-out-in SNCooi out-in ActLoopNT-out 15.758 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.77, 111.89 APE9-dihe-in -104.52, 130.31 APE8-dihe-in -84.87, 65.08 APE8-rot-na 32.16 APE67-dihe-in -62.84, -22.31 -53.23, -38.24 APE12-dist-na 14.003 APE11-dist-na 15.654 APE10-dist-na 10.916 APE9-dist-na 7.529 None None None XRAY 1.87 0.21 0.247 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmi Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None DFGAsp-rot-out 156.98, 152.76 -155.56, 161.93 73.62, -85.77 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-na 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMKA P04629 484 796 796.0 6UG:60901 Type3 Inactive DFGout 12.367 7.444 None DFGAsp-rot-out 155.23, 152.12 -152.95, 175.79 63.96, -81.36 -116.52, 20.57 308.16, 114.44 75.73, 21.77 in-out in 9.763 Saltbr-out 6.397 HRD-in -59.42, -51.85 75.91, -16.02 out-out-in SNCooi out-in ActLoopNT-out 15.471 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.53, 119.76 APE9-dihe-in -107.42, 137.31 APE8-dihe-in -83.03, 63.78 APE8-rot-na 29.2 APE67-dihe-in -62.44, -17.14 -49.56, -42.83 APE12-dist-na 14.029 APE11-dist-na 15.416 APE10-dist-na 11.102 APE9-dist-na 7.25 None None None XRAY 2.24 0.227 0.281 A 329 302 5 0 0 0 [[510, 783]] 1.0 5kmk Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMMA P04629 484 796 796.0 6UJ:60901 Type3 Inactive DFGout 12.368 7.184 None DFGAsp-rot-out 157.73, 155.5 -160.68, 165.48 66.77, -89.3 -107.15, 26.91 307.0, 120.61 71.24, 15.54 in-out in 9.463 Saltbr-out 5.114 HRD-in -61.78, -57.27 78.61, -13.21 out-out-in SNCooi out-in ActLoopNT-out 15.663 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -128.76, 118.16 APE9-dihe-in -103.64, 132.25 APE8-dihe-in -82.99, 66.28 APE8-rot-na 32.09 APE67-dihe-in -66.37, -19.35 -53.37, -35.26 APE12-dist-na 13.548 APE11-dist-na 15.633 APE10-dist-na 11.207 APE9-dist-na 7.428 None None None XRAY 2.12 0.216 0.264 A 329 300 5 0 0 0 [[510, 783]] 1.0 5kmm Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMLA P04629 474 796 796.0 6UH:60901 Type3 Inactive DFGout 12.398 7.282 None DFGAsp-rot-out 158.81, 154.45 -158.96, 169.19 65.27, 88.0 -111.19, 29.55 308.68, 112.5 65.84, 21.76 in-out in 9.957 Saltbr-out 5.226 HRD-out -95.27, 113.75 -82.3, 1.42 out-out-in SNCooi out-in ActLoopNT-out 16.01 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -124.36, 117.18 APE9-dihe-in -101.68, 134.53 APE8-dihe-in -83.65, 62.57 APE8-rot-na 32.66 APE67-dihe-in -60.72, -23.67 -48.68, -40.28 APE12-dist-na 14.512 APE11-dist-na 15.25 APE10-dist-na 11.024 APE9-dist-na 7.223 None None None XRAY 2.01 0.204 0.232 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kml Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMNA P04629 474 796 796.0 6UK:60901 Type3 Inactive DFGout 12.55 7.54 None DFGAsp-rot-out 154.23, 154.5 -157.96, 168.93 64.57, -87.9 -109.62, 31.32 313.55, 117.07 68.77, 19.82 in-out in 9.889 Saltbr-out 4.996 HRD-out -100.52, 112.12 -80.72, -0.22 out-out-in SNCooi out-in ActLoopNT-out 16.168 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -130.74, 114.86 APE9-dihe-in -100.75, 133.2 APE8-dihe-in -82.26, 61.08 APE8-rot-na 30.54 APE67-dihe-in -63.96, -19.55 -48.16, -39.69 APE12-dist-na 14.561 APE11-dist-na 15.367 APE10-dist-na 11.163 APE9-dist-na 7.323 None None None XRAY 2.14 0.195 0.222 A 330 296 8 0 0 0 [[510, 783]] 1.0 5kmn Homo sapiens TYR_NTRK1_HUMAN TYR 2.6e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4I4FA Q05397 415 686 1052.0 1BR:702 Type3 Inactive DFGout 13.674 8.178 None DFGAsp-rot-out -137.25, -178.53 -131.85, 30.21 68.51, -15.91 -146.33, 163.88 55.94, 90.52 -101.82, 157.06 out-out out 10.618 Saltbr-out 6.191 HRD-out -98.84, 110.46 -92.47, -29.67 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 158.93 APE9-dihe-in -71.56, 140.23 APE8-dihe-in -82.88, 69.99 APE8-rot-na 31.14 APE67-dihe-in -67.42, -12.73 -49.69, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.614 APE9-dist-na 8.777 None None None XRAY 1.75 0.188 0.228 A 281 255 17 0 0 14 [[422, 678]] 1.0 4i4f Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
CMGC MAPK14 MK14_MOUSE 5R8YA P47811 4 352 360.0 SMV:401 Type3 Inactive DFGin 7.9 16.793 BLBminus DFGAsp-rot-in -115.18, 174.46 86.01, 79.12 199.49, -7.04 -130.02, 131.19 294.34, 93.85 77.63, 13.6 in-in in 9.45 Saltbr-in 2.815 HRD-in -72.91, -49.09 80.16, -14.98 in-out-out SNCioo out-out ActLoopNT-out 11.08 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.04, 132.68 APE9-dihe-na -64.1, -21.25 APE8-dihe-out -66.93, -11.24 APE8-rot-out 49.29 APE67-dihe-in -64.72, -20.5 -110.83, -19.65 APE12-dist-out 21.89 APE11-dist-out 23.669 APE10-dist-out 17.819 APE9-dist-out 11.505 None None None XRAY 1.679 0.179 0.198 A 360 346 3 0 0 0 [[24, 308]] 1.0 5r8y Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R8ZA P47811 5 352 360.0 SN4:401 Type3 Inactive DFGin 8.083 16.78 BLBminus DFGAsp-rot-in -109.77, 173.86 86.86, 76.26 197.03, -6.13 -126.38, 131.11 295.21, 88.72 77.15, 15.55 in-in in 9.437 Saltbr-in 2.748 HRD-in -74.55, -50.34 76.91, -8.98 in-out-out SNCioo out-out ActLoopNT-out 10.868 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.11, 136.4 APE9-dihe-na -65.57, -21.76 APE8-dihe-out -71.02, -4.43 APE8-rot-out 44.37 APE67-dihe-in -63.83, -21.68 -115.56, -21.67 APE12-dist-out 21.944 APE11-dist-out 23.76 APE10-dist-out 17.921 APE9-dist-out 11.328 None None None XRAY 1.65 0.181 0.194 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r8z Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R97A P47811 5 352 360.0 RUY:401 Type3 Inactive DFGin 8.052 16.786 BLBminus DFGAsp-rot-in -107.35, 174.0 88.72, 75.58 195.78, -0.4 -129.06, 130.07 292.0, 84.81 76.81, 15.71 in-in in 9.135 Saltbr-in 2.862 HRD-in -73.91, -50.02 78.62, -14.33 in-out-out SNCioo out-out ActLoopNT-out 11.006 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.66, 133.31 APE9-dihe-na -61.73, -24.21 APE8-dihe-out -70.48, -5.0 APE8-rot-out 35.58 APE67-dihe-in -62.43, -22.92 -114.02, -22.54 APE12-dist-out 21.971 APE11-dist-out 23.778 APE10-dist-out 17.928 APE9-dist-out 11.399 None None None XRAY 1.438 0.178 0.187 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r97 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9DA P47811 5 352 360.0 N9J:401 Type3 Inactive DFGin 6.906 16.291 BLBminus DFGAsp-rot-out -142.84, -177.62 59.46, 54.53 271.99, -3.27 -49.92, 143.22 293.02, 81.79 -67.58, 124.55 in-in in 9.607 Saltbr-in 2.708 HRD-in -71.3, -52.07 83.51, -18.96 in-out-out SNCioo out-out ActLoopNT-out 10.66 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.54, 137.09 APE9-dihe-na -66.35, -15.51 APE8-dihe-out -64.24, -16.61 APE8-rot-out 49.12 APE67-dihe-in -64.38, -19.38 -115.02, -18.09 APE12-dist-out 21.652 APE11-dist-out 23.92 APE10-dist-out 18.235 APE9-dist-out 11.841 None None None XRAY 1.69 0.192 0.213 A 360 344 4 0 0 0 [[24, 308]] 1.0 5r9d Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9EA P47811 5 352 360.0 S7S:401 Type3 Inactive DFGin 7.674 17.272 BLBminus DFGAsp-rot-out -137.39, 179.1 57.74, 56.07 275.69, 6.79 -53.7, 142.45 286.41, 71.06 -68.12, 115.34 in-in in 9.919 Saltbr-in 2.838 HRD-in -69.03, -54.62 82.77, -10.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.87, 136.52 APE9-dihe-na -64.45, -18.37 APE8-dihe-out -63.84, -12.84 APE8-rot-out 48.2 APE67-dihe-in -64.03, -22.32 -118.18, -18.76 APE12-dist-out 22.053 APE11-dist-out 24.224 APE10-dist-out 18.501 APE9-dist-out 11.84 None None None XRAY 1.775 0.192 0.212 A 360 345 3 0 0 1 [[24, 308]] 1.0 5r9e Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9KA P47811 4 352 360.0 SR4:401 Type3 Inactive DFGin 7.975 16.664 BLBminus DFGAsp-rot-in -109.17, 173.51 89.46, 74.18 201.12, -3.34 -129.95, 129.84 290.88, 85.94 81.01, 12.12 in-in in 9.27 Saltbr-in 2.865 HRD-in -71.68, -50.3 79.29, -13.82 in-out-out SNCioo out-out ActLoopNT-out 10.771 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.69, 132.06 APE9-dihe-na -61.92, -24.83 APE8-dihe-out -67.69, -6.53 APE8-rot-out 49.1 APE67-dihe-in -65.36, -21.0 -113.73, -21.26 APE12-dist-out 21.814 APE11-dist-out 23.654 APE10-dist-out 17.818 APE9-dist-out 11.368 None None None XRAY 1.498 0.19 0.201 A 360 343 6 0 0 0 [[24, 308]] 1.0 5r9k Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9QA P47811 5 352 360.0 LVD:401 Type3 Inactive DFGin 8.188 17.064 BLBminus DFGAsp-rot-out -112.14, 170.23 80.58, 82.07 285.0, 12.86 -125.39, 129.02 290.8, 89.76 79.27, 13.12 in-in in 9.66 Saltbr-in 2.769 HRD-in -79.07, -52.75 78.49, -13.32 in-out-out SNCioo out-out ActLoopNT-out 11.768 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 130.81 APE9-dihe-na -62.18, -18.13 APE8-dihe-out -61.69, -16.69 APE8-rot-out 55.26 APE67-dihe-in -64.61, -20.41 -115.23, -19.01 APE12-dist-out 21.868 APE11-dist-out 23.655 APE10-dist-out 17.812 APE9-dist-out 11.626 None None None XRAY 1.645 0.211 0.229 A 360 346 2 0 0 0 [[24, 308]] 1.0 5r9q Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9WA P47811 5 352 360.0 STV:401 Type3 Inactive DFGin 7.656 16.951 BLBminus DFGAsp-rot-out -134.85, -175.6 55.42, 59.11 281.03, 10.4 -52.2, 138.85 288.54, 71.33 -68.06, 113.57 in-in in 9.773 Saltbr-in 2.847 HRD-in -67.37, -56.08 84.96, -12.7 in-out-out SNCioo out-out ActLoopNT-out 10.075 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.6, 135.98 APE9-dihe-na -66.18, -24.11 APE8-dihe-out -59.13, -22.75 APE8-rot-out 55.31 APE67-dihe-in -66.54, -23.46 -107.25, -17.91 APE12-dist-out 22.242 APE11-dist-out 24.41 APE10-dist-out 18.608 APE9-dist-out 11.757 None None None XRAY 1.89 0.176 0.204 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r9w Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5RA1A P47811 5 352 360.0 PO6:401 Type3 Inactive DFGin 8.032 16.967 BLBminus DFGAsp-rot-in -116.6, 170.37 81.52, 81.7 188.64, 5.04 -127.11, 124.0 290.13, 89.2 75.77, 17.38 in-in in 9.598 Saltbr-in 2.767 HRD-in -67.99, -54.24 81.95, -19.51 in-out-out SNCioo out-out ActLoopNT-out 11.33 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 131.95 APE9-dihe-na -63.72, -22.68 APE8-dihe-out -62.28, -13.71 APE8-rot-out 51.04 APE67-dihe-in -62.19, -23.02 -116.68, -25.26 APE12-dist-out 21.982 APE11-dist-out 23.809 APE10-dist-out 17.926 APE9-dist-out 11.478 None None None XRAY 1.61 0.188 0.213 A 360 348 0 0 0 0 [[24, 308]] 1.0 5ra1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5RA9A P47811 5 352 360.0 SWD:401 Type3 Inactive DFGin 7.838 16.606 BLBminus DFGAsp-rot-in -112.11, 165.99 91.45, 84.17 192.1, -1.71 -130.08, 120.06 293.76, 89.11 79.19, 18.98 in-in in 9.422 Saltbr-in 3.02 HRD-in -67.29, -51.81 76.3, -9.73 in-out-out SNCioo out-out ActLoopNT-out 11.052 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.7 APE9-dihe-na -64.27, -25.04 APE8-dihe-out -60.75, -16.06 APE8-rot-out 55.77 APE67-dihe-in -64.26, -22.13 -114.22, -21.12 APE12-dist-out 21.949 APE11-dist-out 23.811 APE10-dist-out 17.937 APE9-dist-out 11.598 None None None XRAY 1.68 0.185 0.201 A 360 348 0 0 0 0 [[24, 308]] 1.0 5ra9 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P5KA P47811 5 352 360.0 P5K:362 Type3 Inactive DFGout 14.525 9.308 BBAminus DFGAsp-rot-in -141.15, -168.68 -148.23, 99.3 193.76, -9.82 -58.18, -32.6 276.48, 90.7 88.55, 999.0 in-in in 8.606 Saltbr-in 2.79 HRD-in -63.98, -57.19 74.55, -12.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.21 APE8-dihe-out -61.52, -32.15 APE8-rot-in 260.23 APE67-dihe-in -70.66, -25.54 -65.62, -20.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.546 None None None XRAY 2.09 0.214 0.265 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p5k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P78A P47811 5 352 360.0 P78:362 Type3 Inactive DFGout 13.709 9.668 BBAminus DFGAsp-rot-in -145.29, -172.71 -144.52, 103.86 182.63, -3.53 -60.78, -27.28 283.97, 109.45 117.0, 999.0 in-in in 9.49 Saltbr-in 2.844 HRD-in -69.5, -62.61 90.57, -20.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.4 APE8-dihe-out -43.61, -34.17 APE8-rot-in 261.47 APE67-dihe-in -68.8, -24.58 -57.91, -21.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.807 None None None XRAY 2.3 0.247 0.313 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p78 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P79A P47811 5 352 360.0 P79:362 Type3 Inactive DFGout 14.0 9.873 BBAminus DFGAsp-rot-in -151.22, -174.47 -141.93, 101.48 186.17, -1.16 -66.27, -17.47 283.09, 111.48 104.1, 999.0 in-in in 9.228 Saltbr-in 2.786 HRD-in -63.58, -58.2 79.24, -16.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.77 APE8-dihe-out -56.29, -31.49 APE8-rot-in 268.32 APE67-dihe-in -72.21, -24.76 -62.87, -19.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.524 None None None XRAY 2.1 0.213 0.27 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p79 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7AA P47811 5 352 360.0 P7A:362 Type3 Inactive DFGout 14.019 8.951 BBAminus DFGAsp-rot-in -141.3, -162.35 -154.35, 95.38 195.03, -6.53 -72.41, 28.1 269.3, 92.19 44.28, 999.0 in-in in 8.826 Saltbr-in 3.158 HRD-in -68.47, -56.82 86.62, -20.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.86 APE8-dihe-out -40.2, -40.94 APE8-rot-in 279.74 APE67-dihe-in -55.35, -23.72 -65.33, -37.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.041 None None None XRAY 2.31 0.23 0.298 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7a Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7BA P47811 5 352 360.0 P7B:362 Type3 Inactive DFGout 14.322 9.131 BBAminus DFGAsp-rot-in -139.72, -169.55 -146.44, 103.45 185.46, -12.04 -68.51, -32.05 266.87, 101.4 106.97, 999.0 in-in in 8.836 Saltbr-in 2.915 HRD-in -63.72, -60.5 81.04, -16.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.57 APE8-dihe-out -51.57, -34.06 APE8-rot-in 268.36 APE67-dihe-in -70.75, -19.21 -60.51, -28.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.489 None None None XRAY 1.9 0.224 0.265 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7b Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7CA P47811 5 352 360.0 P7C:362 Type3 Inactive DFGout 14.184 8.886 BBAminus DFGAsp-rot-in -148.94, 179.04 -136.31, 98.75 195.2, -12.32 -67.28, -8.09 273.29, 107.9 73.35, 999.0 in-in in 8.665 Saltbr-in 3.002 HRD-in -66.58, -58.56 78.92, -19.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.98 APE8-dihe-out -68.5, -25.84 APE8-rot-out 232.65 APE67-dihe-in -58.76, -32.39 -62.96, -27.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.887 None None None XRAY 2.3 0.239 0.292 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7c Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

All / All / Type3

Total number of chains: 17
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 10 58.8% 5R97A
DFGout BBAminus 7 41.2% 3P7BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3F3UB P00523 257 533 533.0 1AW:1 Type3 Inactive DFGout 15.336 9.183 BBAminus DFGAsp-rot-in -141.0, -173.96 -153.88, 116.05 190.7, -21.88 -70.03, -22.13 273.23, 93.9 97.77, 28.5 in-out in 8.179 Saltbr-out 4.092 HRD-in -96.28, -57.27 85.03, -8.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.31 APE8-dihe-in -63.37, 107.9 APE8-rot-na 21.01 APE67-dihe-in -72.88, -5.99 -68.0, -15.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.765 S345C None None XRAY 2.5 0.224 0.281 B 286 259 18 0 0 16 [[267, 518]] 1.0 3f3u Gallus gallus TYR_SRC_CHICK TYR 4.6e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC MAPK14 MK14_MOUSE 5R8YA P47811 4 352 360.0 SMV:401 Type3 Inactive DFGin 7.9 16.793 BLBminus DFGAsp-rot-in -115.18, 174.46 86.01, 79.12 199.49, -7.04 -130.02, 131.19 294.34, 93.85 77.63, 13.6 in-in in 9.45 Saltbr-in 2.815 HRD-in -72.91, -49.09 80.16, -14.98 in-out-out SNCioo out-out ActLoopNT-out 11.08 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.04, 132.68 APE9-dihe-na -64.1, -21.25 APE8-dihe-out -66.93, -11.24 APE8-rot-out 49.29 APE67-dihe-in -64.72, -20.5 -110.83, -19.65 APE12-dist-out 21.89 APE11-dist-out 23.669 APE10-dist-out 17.819 APE9-dist-out 11.505 None None None XRAY 1.679 0.179 0.198 A 360 346 3 0 0 0 [[24, 308]] 1.0 5r8y Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R8ZA P47811 5 352 360.0 SN4:401 Type3 Inactive DFGin 8.083 16.78 BLBminus DFGAsp-rot-in -109.77, 173.86 86.86, 76.26 197.03, -6.13 -126.38, 131.11 295.21, 88.72 77.15, 15.55 in-in in 9.437 Saltbr-in 2.748 HRD-in -74.55, -50.34 76.91, -8.98 in-out-out SNCioo out-out ActLoopNT-out 10.868 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.11, 136.4 APE9-dihe-na -65.57, -21.76 APE8-dihe-out -71.02, -4.43 APE8-rot-out 44.37 APE67-dihe-in -63.83, -21.68 -115.56, -21.67 APE12-dist-out 21.944 APE11-dist-out 23.76 APE10-dist-out 17.921 APE9-dist-out 11.328 None None None XRAY 1.65 0.181 0.194 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r8z Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R97A P47811 5 352 360.0 RUY:401 Type3 Inactive DFGin 8.052 16.786 BLBminus DFGAsp-rot-in -107.35, 174.0 88.72, 75.58 195.78, -0.4 -129.06, 130.07 292.0, 84.81 76.81, 15.71 in-in in 9.135 Saltbr-in 2.862 HRD-in -73.91, -50.02 78.62, -14.33 in-out-out SNCioo out-out ActLoopNT-out 11.006 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.66, 133.31 APE9-dihe-na -61.73, -24.21 APE8-dihe-out -70.48, -5.0 APE8-rot-out 35.58 APE67-dihe-in -62.43, -22.92 -114.02, -22.54 APE12-dist-out 21.971 APE11-dist-out 23.778 APE10-dist-out 17.928 APE9-dist-out 11.399 None None None XRAY 1.438 0.178 0.187 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r97 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9DA P47811 5 352 360.0 N9J:401 Type3 Inactive DFGin 6.906 16.291 BLBminus DFGAsp-rot-out -142.84, -177.62 59.46, 54.53 271.99, -3.27 -49.92, 143.22 293.02, 81.79 -67.58, 124.55 in-in in 9.607 Saltbr-in 2.708 HRD-in -71.3, -52.07 83.51, -18.96 in-out-out SNCioo out-out ActLoopNT-out 10.66 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.54, 137.09 APE9-dihe-na -66.35, -15.51 APE8-dihe-out -64.24, -16.61 APE8-rot-out 49.12 APE67-dihe-in -64.38, -19.38 -115.02, -18.09 APE12-dist-out 21.652 APE11-dist-out 23.92 APE10-dist-out 18.235 APE9-dist-out 11.841 None None None XRAY 1.69 0.192 0.213 A 360 344 4 0 0 0 [[24, 308]] 1.0 5r9d Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9EA P47811 5 352 360.0 S7S:401 Type3 Inactive DFGin 7.674 17.272 BLBminus DFGAsp-rot-out -137.39, 179.1 57.74, 56.07 275.69, 6.79 -53.7, 142.45 286.41, 71.06 -68.12, 115.34 in-in in 9.919 Saltbr-in 2.838 HRD-in -69.03, -54.62 82.77, -10.63 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -135.87, 136.52 APE9-dihe-na -64.45, -18.37 APE8-dihe-out -63.84, -12.84 APE8-rot-out 48.2 APE67-dihe-in -64.03, -22.32 -118.18, -18.76 APE12-dist-out 22.053 APE11-dist-out 24.224 APE10-dist-out 18.501 APE9-dist-out 11.84 None None None XRAY 1.775 0.192 0.212 A 360 345 3 0 0 1 [[24, 308]] 1.0 5r9e Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9KA P47811 4 352 360.0 SR4:401 Type3 Inactive DFGin 7.975 16.664 BLBminus DFGAsp-rot-in -109.17, 173.51 89.46, 74.18 201.12, -3.34 -129.95, 129.84 290.88, 85.94 81.01, 12.12 in-in in 9.27 Saltbr-in 2.865 HRD-in -71.68, -50.3 79.29, -13.82 in-out-out SNCioo out-out ActLoopNT-out 10.771 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.69, 132.06 APE9-dihe-na -61.92, -24.83 APE8-dihe-out -67.69, -6.53 APE8-rot-out 49.1 APE67-dihe-in -65.36, -21.0 -113.73, -21.26 APE12-dist-out 21.814 APE11-dist-out 23.654 APE10-dist-out 17.818 APE9-dist-out 11.368 None None None XRAY 1.498 0.19 0.201 A 360 343 6 0 0 0 [[24, 308]] 1.0 5r9k Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9QA P47811 5 352 360.0 LVD:401 Type3 Inactive DFGin 8.188 17.064 BLBminus DFGAsp-rot-out -112.14, 170.23 80.58, 82.07 285.0, 12.86 -125.39, 129.02 290.8, 89.76 79.27, 13.12 in-in in 9.66 Saltbr-in 2.769 HRD-in -79.07, -52.75 78.49, -13.32 in-out-out SNCioo out-out ActLoopNT-out 11.768 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.25, 130.81 APE9-dihe-na -62.18, -18.13 APE8-dihe-out -61.69, -16.69 APE8-rot-out 55.26 APE67-dihe-in -64.61, -20.41 -115.23, -19.01 APE12-dist-out 21.868 APE11-dist-out 23.655 APE10-dist-out 17.812 APE9-dist-out 11.626 None None None XRAY 1.645 0.211 0.229 A 360 346 2 0 0 0 [[24, 308]] 1.0 5r9q Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5R9WA P47811 5 352 360.0 STV:401 Type3 Inactive DFGin 7.656 16.951 BLBminus DFGAsp-rot-out -134.85, -175.6 55.42, 59.11 281.03, 10.4 -52.2, 138.85 288.54, 71.33 -68.06, 113.57 in-in in 9.773 Saltbr-in 2.847 HRD-in -67.37, -56.08 84.96, -12.7 in-out-out SNCioo out-out ActLoopNT-out 10.075 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -132.6, 135.98 APE9-dihe-na -66.18, -24.11 APE8-dihe-out -59.13, -22.75 APE8-rot-out 55.31 APE67-dihe-in -66.54, -23.46 -107.25, -17.91 APE12-dist-out 22.242 APE11-dist-out 24.41 APE10-dist-out 18.608 APE9-dist-out 11.757 None None None XRAY 1.89 0.176 0.204 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r9w Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5RA1A P47811 5 352 360.0 PO6:401 Type3 Inactive DFGin 8.032 16.967 BLBminus DFGAsp-rot-in -116.6, 170.37 81.52, 81.7 188.64, 5.04 -127.11, 124.0 290.13, 89.2 75.77, 17.38 in-in in 9.598 Saltbr-in 2.767 HRD-in -67.99, -54.24 81.95, -19.51 in-out-out SNCioo out-out ActLoopNT-out 11.33 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -137.06, 131.95 APE9-dihe-na -63.72, -22.68 APE8-dihe-out -62.28, -13.71 APE8-rot-out 51.04 APE67-dihe-in -62.19, -23.02 -116.68, -25.26 APE12-dist-out 21.982 APE11-dist-out 23.809 APE10-dist-out 17.926 APE9-dist-out 11.478 None None None XRAY 1.61 0.188 0.213 A 360 348 0 0 0 0 [[24, 308]] 1.0 5ra1 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 5RA9A P47811 5 352 360.0 SWD:401 Type3 Inactive DFGin 7.838 16.606 BLBminus DFGAsp-rot-in -112.11, 165.99 91.45, 84.17 192.1, -1.71 -130.08, 120.06 293.76, 89.11 79.19, 18.98 in-in in 9.422 Saltbr-in 3.02 HRD-in -67.29, -51.81 76.3, -9.73 in-out-out SNCioo out-out ActLoopNT-out 11.052 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -134.19, 133.7 APE9-dihe-na -64.27, -25.04 APE8-dihe-out -60.75, -16.06 APE8-rot-out 55.77 APE67-dihe-in -64.26, -22.13 -114.22, -21.12 APE12-dist-out 21.949 APE11-dist-out 23.811 APE10-dist-out 17.937 APE9-dist-out 11.598 None None None XRAY 1.68 0.185 0.201 A 360 348 0 0 0 0 [[24, 308]] 1.0 5ra9 Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P5KA P47811 5 352 360.0 P5K:362 Type3 Inactive DFGout 14.525 9.308 BBAminus DFGAsp-rot-in -141.15, -168.68 -148.23, 99.3 193.76, -9.82 -58.18, -32.6 276.48, 90.7 88.55, 999.0 in-in in 8.606 Saltbr-in 2.79 HRD-in -63.98, -57.19 74.55, -12.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.21 APE8-dihe-out -61.52, -32.15 APE8-rot-in 260.23 APE67-dihe-in -70.66, -25.54 -65.62, -20.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.546 None None None XRAY 2.09 0.214 0.265 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p5k Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P78A P47811 5 352 360.0 P78:362 Type3 Inactive DFGout 13.709 9.668 BBAminus DFGAsp-rot-in -145.29, -172.71 -144.52, 103.86 182.63, -3.53 -60.78, -27.28 283.97, 109.45 117.0, 999.0 in-in in 9.49 Saltbr-in 2.844 HRD-in -69.5, -62.61 90.57, -20.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.4 APE8-dihe-out -43.61, -34.17 APE8-rot-in 261.47 APE67-dihe-in -68.8, -24.58 -57.91, -21.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.807 None None None XRAY 2.3 0.247 0.313 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p78 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P79A P47811 5 352 360.0 P79:362 Type3 Inactive DFGout 14.0 9.873 BBAminus DFGAsp-rot-in -151.22, -174.47 -141.93, 101.48 186.17, -1.16 -66.27, -17.47 283.09, 111.48 104.1, 999.0 in-in in 9.228 Saltbr-in 2.786 HRD-in -63.58, -58.2 79.24, -16.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.77 APE8-dihe-out -56.29, -31.49 APE8-rot-in 268.32 APE67-dihe-in -72.21, -24.76 -62.87, -19.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.524 None None None XRAY 2.1 0.213 0.27 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p79 Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7AA P47811 5 352 360.0 P7A:362 Type3 Inactive DFGout 14.019 8.951 BBAminus DFGAsp-rot-in -141.3, -162.35 -154.35, 95.38 195.03, -6.53 -72.41, 28.1 269.3, 92.19 44.28, 999.0 in-in in 8.826 Saltbr-in 3.158 HRD-in -68.47, -56.82 86.62, -20.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.86 APE8-dihe-out -40.2, -40.94 APE8-rot-in 279.74 APE67-dihe-in -55.35, -23.72 -65.33, -37.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.041 None None None XRAY 2.31 0.23 0.298 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7a Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7BA P47811 5 352 360.0 P7B:362 Type3 Inactive DFGout 14.322 9.131 BBAminus DFGAsp-rot-in -139.72, -169.55 -146.44, 103.45 185.46, -12.04 -68.51, -32.05 266.87, 101.4 106.97, 999.0 in-in in 8.836 Saltbr-in 2.915 HRD-in -63.72, -60.5 81.04, -16.22 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.57 APE8-dihe-out -51.57, -34.06 APE8-rot-in 268.36 APE67-dihe-in -70.75, -19.21 -60.51, -28.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.489 None None None XRAY 1.9 0.224 0.265 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7b Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_MOUSE 3P7CA P47811 5 352 360.0 P7C:362 Type3 Inactive DFGout 14.184 8.886 BBAminus DFGAsp-rot-in -148.94, 179.04 -136.31, 98.75 195.2, -12.32 -67.28, -8.09 273.29, 107.9 73.35, 999.0 in-in in 8.665 Saltbr-in 3.002 HRD-in -66.58, -58.56 78.92, -19.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.98 APE8-dihe-out -68.5, -25.84 APE8-rot-out 232.65 APE67-dihe-in -58.76, -32.39 -62.96, -27.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.887 None None None XRAY 2.3 0.239 0.292 A 366 332 16 0 0 13 [[24, 308]] 1.0 3p7c Mus musculus CMGC_MAPK14_MOUSE CMGC 2.1e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14