All / All / Type1.5_Front

Total number of chains: 180
Active chains: 7
Total number of genes: 38
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 65 36.1% 4QTBA
DFGin None 24 13.3% 5HHWA
DFGin ABAminus 23 12.8% 6GR8A
DFGin BLBminus 18 10.0% 7QGPA
DFGin BLBplus 10 5.6% 7AVXA
DFGinter None 9 5.0% 9KS5B
DFGout BBAminus 9 5.0% 6PDJA
DFGin BLBtrans 7 3.9% 3VRZB
DFGin BLAplus 5 2.8% 7YAWB
DFGout None 5 2.8% 6HJKA
None None 5 2.8% 2C6EB

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 3QKKA P31749 144 478 480.0 SMH:60001 Type1.5_Front Inactive DFGin 6.383 13.598 BLAminus DFGAsp-rot-out -116.54, -179.44 52.7, 85.0 291.28, -88.93 -102.02, 14.36 303.33, 93.01 -66.45, -23.02 in-in in 8.916 Saltbr-in 2.342 HRD-in -78.65, -51.68 79.72, -12.12 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.57, 164.52 APE9-dihe-na 135.56, -139.12 APE8-dihe-in -127.86, 127.7 APE8-rot-in 299.02 APE67-dihe-in -62.38, -25.83 -44.42, -46.66 APE12-dist-in 8.22 APE11-dist-in 11.566 APE10-dist-in 6.028 APE9-dist-in 3.779 S473D TPO308 TPO308 XRAY 2.3 0.202 0.25 A 341 327 0 0 0 0 [[150, 408]] 1.0 3qkk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK2 ARBK1_HUMAN 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.407 13.123 BLAminus DFGAsp-rot-in -119.49, 148.71 76.08, 97.29 197.42, -12.71 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.399 Saltbr-in 2.971 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.151 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.922 APE11-dist-in 11.89 APE10-dist-in 5.931 APE9-dist-in 3.549 None None None XRAY 2.7 0.215 0.257 A 547 414 0 0 0 0 [[191, 453]] 1.0 5uuu AGC_GRK2_HUMAN AGC 3.8e-77 268.3 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKKA P25098 30 667 689.0 8DJ:702 Type1.5_Front Inactive DFGin 5.44 12.848 BLAminus DFGAsp-rot-out -148.52, 179.61 57.76, 73.54 251.91, 52.8 -87.98, 8.97 274.06, 69.08 -60.04, -18.89 in-in in 8.271 Saltbr-in 2.669 HRD-in -76.24, -37.94 75.49, -51.75 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.39, 145.94 APE9-dihe-na 143.2, -151.45 APE8-dihe-in -131.14, 141.32 APE8-rot-in 299.97 APE67-dihe-in -67.12, -33.98 -48.24, -30.82 APE12-dist-in 9.635 APE11-dist-in 11.819 APE10-dist-in 5.846 APE9-dist-in 4.157 S670A None None XRAY 2.6 0.224 0.281 A 642 613 0 0 0 0 [[191, 453]] 1.0 5ukk AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 6U7CA P25098 30 669 689.0 Q1Y:701 Type1.5_Front Inactive DFGin 5.061 12.454 BLAminus DFGAsp-rot-out -136.54, 170.55 57.52, 81.77 289.0, 20.73 -86.77, 20.22 308.16, 7.53 -58.1, -34.47 in-in in 9.05 Saltbr-in 2.543 HRD-in -72.35, -46.72 70.07, -13.25 in-in-in SNCiii in-in ActLoopNT-in 3.37 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 132.95 APE9-dihe-na 147.35, -168.5 APE8-dihe-in -105.63, 128.22 APE8-rot-in 297.44 APE67-dihe-inflip 124.86, -14.55 -55.92, 113.23 APE12-dist-in 10.206 APE11-dist-in 12.016 APE10-dist-in 6.072 APE9-dist-in 3.485 None None None XRAY 2.44 0.237 0.262 A 689 631 0 0 0 0 [[191, 453]] 1.0 6u7c AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCYA O15530 73 358 556.0 3Q3:371 Type1.5_Front Inactive DFGin 6.388 14.592 BLAminus DFGAsp-rot-in -136.93, -173.16 70.99, 75.14 183.59, 13.71 -110.32, 14.26 284.13, 86.28 -62.73, -28.34 in-in in 8.419 Saltbr-in 2.559 HRD-in -71.32, -53.51 82.01, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 125.83 APE9-dihe-na -76.07, -148.77 APE8-dihe-in -79.07, 127.11 APE8-rot-in 312.38 APE67-dihe-in -58.65, -24.48 -40.2, -55.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.317 APE9-dist-in 4.499 None SEP241 SEP241 XRAY 2.2 0.181 0.212 A 312 275 11 0 0 11 [[82, 342]] 1.0 3qcy AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.584 14.791 BLAminus DFGAsp-rot-in -135.89, -173.14 73.55, 73.02 182.88, 14.17 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.526 Saltbr-in 2.573 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.765 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312 274 12 0 0 12 [[82, 342]] 1.0 3qd0 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD3A O15530 71 358 556.0 3Q5:360 Type1.5_Front Inactive DFGin 6.64 14.776 BLAminus DFGAsp-rot-in -136.15, -173.35 75.08, 78.84 181.88, 8.0 -114.86, 7.79 284.21, 92.48 -60.8, -30.07 in-in in 8.47 Saltbr-in 2.547 HRD-in -69.84, -52.9 76.92, -8.58 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.87, 124.76 APE9-dihe-na -70.78, -165.19 APE8-dihe-in -61.65, 129.32 APE8-rot-in 306.27 APE67-dihe-in -62.1, -22.78 -46.86, -49.49 APE12-dist-in 8.992 APE11-dist-out 5.734 APE10-dist-out 10.414 APE9-dist-in 4.038 None SEP241 SEP241 XRAY 2.0 0.185 0.211 A 312 279 9 0 0 9 [[82, 342]] 1.0 3qd3 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.403 14.626 BLAminus DFGAsp-rot-in -137.72, -173.39 72.99, 75.84 178.14, 13.4 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.558 Saltbr-in 2.79 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.12 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312 276 12 0 0 12 [[82, 342]] 1.0 3qd4 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6C0TA Q13976 337 671 671.0 EE4:701 Type1.5_Front Inactive DFGin 5.9 14.257 BLAminus DFGAsp-rot-out -131.41, 173.3 67.52, 81.76 264.71, -7.5 -101.27, 23.85 278.07, 65.63 -65.26, -23.23 in-in in 8.935 Saltbr-in 2.797 HRD-in -100.02, -51.71 77.78, -11.77 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.5, 158.55 APE9-dihe-na 107.94, 162.3 APE8-dihe-in -69.48, 141.18 APE8-rot-out 79.81 APE67-dihe-in -72.66, -16.0 -52.58, -33.36 APE12-dist-in 7.74 APE11-dist-in 11.364 APE10-dist-in 5.987 APE9-dist-in 4.819 None TPO517 TPO517 XRAY 1.98 0.21 0.244 A 347 335 0 0 0 0 [[360, 619]] 1.0 6c0t AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUA Q13464 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus DFGAsp-rot-in -144.77, -177.33 55.22, 80.15 194.27, 8.27 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUB Q13464 6 402 1354.0 65R:60501 Type1.5_Front Inactive DFGin 6.027 12.975 BLAminus DFGAsp-rot-in -150.94, 172.97 62.5, 81.89 189.92, 10.32 -105.96, 31.62 305.32, 102.48 -65.13, -10.17 in-in in 8.313 Saltbr-in 2.938 HRD-in -68.69, -52.17 76.83, -16.13 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.5 APE8-rot-out 85.32 APE67-dihe-in -36.29, -45.18 -89.86, -8.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.239 0.248 B 415 393 4 0 0 4 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSB Q13464 6 402 1354.0 6U1:60501 Type1.5_Front Inactive DFGin 6.14 13.336 BLAminus DFGAsp-rot-in -142.66, 177.11 58.73, 60.85 198.24, -30.27 -80.32, 21.73 304.44, 101.0 -56.11, -39.34 in-in in 8.227 Saltbr-in 2.746 HRD-in -68.72, -42.28 78.49, -44.71 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -104.48, 133.16 APE9-dihe-na -95.73, 130.38 APE8-dihe-out 63.66, 89.81 APE8-rot-out 67.34 APE67-dihe-in -44.41, -53.62 -78.83, 5.04 APE12-dist-in 8.715 APE11-dist-in 12.174 APE10-dist-out 8.649 APE9-dist-out 10.213 None None None XRAY 3.3 0.215 0.254 B 415 394 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTB Q13464 6 402 1354.0 6U2:60501 Type1.5_Front Inactive DFGin 6.306 13.599 BLAminus DFGAsp-rot-in -130.02, -177.11 50.1, 80.15 197.72, -0.81 -95.96, 18.23 299.48, 98.02 -62.02, -10.47 in-in in 8.889 Saltbr-in 2.78 HRD-in -68.38, -47.41 71.48, -14.73 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -110.61, 86.79 APE9-dihe-na -63.17, 97.09 APE8-dihe-out 74.12, 110.85 APE8-rot-in 316.95 APE67-dihe-in -53.36, -37.05 -91.57, 10.0 APE12-dist-in 8.432 APE11-dist-in 11.357 APE10-dist-out 10.199 APE9-dist-out 9.422 None None None XRAY 2.8 0.223 0.237 B 415 393 0 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEA Q13464 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus DFGAsp-rot-in -135.0, 175.35 53.04, 84.77 186.88, 58.35 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus DFGAsp-rot-in -143.39, 177.51 52.52, 73.92 190.34, 63.29 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEC Q13464 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus DFGAsp-rot-in -141.6, 173.01 60.67, 84.57 201.57, -2.47 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNED Q13464 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus DFGAsp-rot-in -136.38, 179.68 48.06, 76.76 196.48, 0.38 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.02 13.098 BLAminus DFGAsp-rot-in -129.77, 174.02 63.85, 83.94 193.25, 3.03 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.669 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.222 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399 377 13 0 0 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OG O75116 25 417 1388.0 5YK:501 Type1.5_Front Inactive DFGin 6.03 13.093 BLAminus DFGAsp-rot-in -130.18, 173.76 63.87, 84.33 192.84, 2.47 -107.4, 35.32 304.41, 101.68 -72.33, -45.62 in-in in 8.657 Saltbr-in 2.757 HRD-in -67.47, -41.36 68.16, 2.55 in-in-out SNCiio in-out ActLoopNT-in 3.223 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.99 APE67-dihe-in -56.93, -36.54 -73.99, -19.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 G 399 381 8 0 0 5 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.031 13.142 BLAminus DFGAsp-rot-in -130.18, 173.86 63.9, 84.23 193.08, 2.31 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.685 Saltbr-in 2.757 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.218 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399 369 19 0 0 14 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6B O75116 28 416 1388.0 J0P:501 Type1.5_Front Inactive DFGin 6.399 13.183 BLAminus DFGAsp-rot-in -141.53, 178.3 54.07, 109.38 181.19, -78.21 -133.99, 38.6 302.74, 88.83 -73.72, -23.58 in-in in 8.537 Saltbr-in 2.814 HRD-in -63.89, -44.38 75.08, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.55 APE8-dihe-in -56.82, 118.75 APE8-rot-in 295.99 APE67-dihe-in -40.0, -36.43 -89.99, -12.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.059 None None None XRAY 2.86 0.206 0.247 B 415 364 18 0 0 12 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.7e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSD O75116 24 417 1388.0 Z8O:501 Type1.5_Front Inactive DFGout 14.51 9.548 BBAminus DFGAsp-rot-in -103.86, 141.89 -103.51, 117.86 171.51, 42.11 -102.63, 25.16 306.33, 142.76 108.24, 20.62 out-none out 14.969 Saltbr-none 999.0 HRD-in -60.5, -48.74 68.07, -4.31 none-in-none SNCnin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 89.84 APE9-dihe-na 170.11, -172.34 APE8-dihe-in -98.69, 124.47 APE8-rot-in 291.85 APE67-dihe-in -51.67, -33.01 -41.58, -52.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.122 APE9-dist-in 4.517 None None None XRAY 2.71 0.218 0.248 D 396 379 10 0 0 5 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
CAMK AURKA AURKA_HUMAN 6GRAA O14965 126 389 403.0 F8Z:501 Type1.5_Front Inactive DFGin 5.009 16.668 ABAminus DFGAsp-rot-out -83.94, -29.2 -118.43, -178.38 294.57, -77.49 -109.45, -4.58 278.61, 93.03 97.03, -121.48 out-out out 11.018 Saltbr-out 9.639 HRD-in -78.52, -51.2 68.01, 5.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-none 999.0 APE67-dihe-in -48.59, -35.52 -71.59, -26.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.213 0.269 A 285 250 14 0 0 14 [[133, 383]] 1.0 6gra CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3M11A O14965 126 391 403.0 AKI:1 Type1.5_Front Inactive DFGin 6.963 16.704 BLAminus DFGAsp-rot-in -121.88, 165.26 64.27, 67.3 185.37, -16.53 -73.83, 6.74 288.37, 76.5 -59.9, -23.24 out-out out 11.142 Saltbr-out 7.507 HRD-out -96.16, 99.79 -59.97, -43.23 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.15 APE8-dihe-in -53.14, 136.39 APE8-rot-in 259.54 APE67-dihe-in -40.98, -33.42 -92.04, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.255 T288D None None XRAY 2.75 0.221 0.299 A 279 256 10 0 0 10 [[133, 383]] 1.0 3m11 CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBPA O14965 126 390 403.0 YPH:501 Type1.5_Front Inactive DFGin 5.813 16.221 BLAminus DFGAsp-rot-in -117.4, 167.72 63.38, 95.52 189.71, -6.66 -104.02, 27.08 282.25, 81.8 -62.06, -18.61 out-out out 10.824 Saltbr-out 7.164 HRD-in -70.59, -54.13 72.42, 1.53 out-in-out SNCoio in-out ActLoopNT-in 3.475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.17 APE8-dihe-in -73.05, 143.32 APE8-rot-out 208.85 APE67-dihe-in -51.16, -32.61 -84.83, -4.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 T288D None None XRAY 2.45 0.226 0.291 A 279 255 10 0 0 10 [[133, 383]] 1.0 4jbp CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.77 14.737 None DFGAsp-rot-in -129.81, 37.03 -50.55, -31.01 189.99, 29.16 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.615 Saltbr-out 8.842 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.598 None None None XRAY 3.2 0.215 0.262 A 287 254 8 0 0 8 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 8.1e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.576 14.72 None DFGAsp-rot-in -129.5, 39.33 -48.31, -42.14 198.54, 7.32 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.397 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.587 APE11-dist-out 15.405 APE10-dist-out 16.527 APE9-dist-out 9.503 None None None XRAY 3.2 0.215 0.262 B 287 258 7 0 0 7 [[133, 383]] 1.0 4uzd CAMK_AURKA_HUMAN CAMK 8.1e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.695 14.011 None DFGAsp-rot-out -129.71, 33.27 -11.88, -124.06 106.65, -41.19 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.431 Saltbr-out 9.442 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287 249 18 0 0 16 [[133, 383]] 1.0 4uyn CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.166 9.192 None DFGAsp-rot-in -114.69, 29.1 -93.31, 98.64 213.81, -64.46 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.504 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267 240 23 0 0 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.843 8.718 None DFGAsp-rot-out -97.71, -18.22 -58.8, 127.67 296.84, -65.8 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.752 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267 242 22 0 0 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.926 8.59 None DFGAsp-rot-in -120.45, 57.47 -126.6, 83.94 204.27, -76.74 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.771 Saltbr-out 9.688 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267 246 17 0 0 14 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.129 8.801 None DFGAsp-rot-in -108.79, 36.5 -105.08, 99.13 215.11, 89.31 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.868 Saltbr-out 9.636 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.327 None None None XRAY 2.0 0.285 0.351 B 267 249 15 0 0 11 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.493 None DFGAsp-rot-out -112.85, -19.21 -86.09, 145.25 84.13, -52.92 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.308 Saltbr-out 9.311 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.22 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285 256 11 0 0 11 [[133, 383]] 1.0 6hjj CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.921 9.215 None DFGAsp-rot-in -125.94, 46.56 -78.14, 156.47 236.2, 69.99 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.863 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267 246 17 0 0 17 [[133, 383]] 1.0 3o51 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJKA O14965 127 391 403.0 G7W:501 Type1.5_Front Inactive DFGout 16.17 11.028 None DFGAsp-rot-out -98.89, -43.18 56.05, 51.38 278.3, -40.51 -26.46, 122.09 241.09, 49.93 -75.8, 146.41 out-none out 11.513 Saltbr-none 999.0 HRD-out -101.06, -164.07 153.73, -179.93 none-out-out SNCnoo out-out ActLoopNT-out 20.184 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -66.21 APE9-dihe-na -150.91, 1.99 APE8-dihe-out -109.25, 19.55 APE8-rot-in 313.76 APE67-dihe-in -56.8, -21.9 -54.42, -38.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.652 APE9-dist-out 13.829 L210C,C290A,C393A None None XRAY 2.4 0.219 0.252 A 285 255 10 0 0 10 [[133, 383]] 1.0 6hjk CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6EB O14965 127 388 403.0 HPM:61388 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -108.73, 147.84 100.58, 999.0 257.72, -11.81 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.334 Saltbr-out 11.707 HRD-in -74.71, -88.37 86.19, 28.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.56 APE8-dihe-out -69.38, -179.33 APE8-rot-out 55.29 APE67-dihe-in -54.24, -12.3 -58.45, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.566 None None None XRAY 2.1 0.2 0.27 B 283 246 16 0 0 16 [[133, 383]] 1.0 2c6e CAMK_AURKA_HUMAN CAMK 1.8e-79 272.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKC AURKC_HUMAN 6GR8A Q9UQB9 36 303 309.0 F8Z:60401 Type1.5_Front Inactive DFGin 6.388 16.369 ABAminus DFGAsp-rot-in -86.33, -37.22 -148.5, 121.35 170.36, 20.14 -101.84, 15.84 276.95, 115.08 -62.41, -31.31 out-out out 10.659 Saltbr-out 7.756 HRD-in -76.6, -55.3 75.61, 5.87 out-in-out SNCoio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.48, 154.35 APE9-dihe-na 86.68, -167.53 APE8-dihe-in -103.19, 151.93 APE8-rot-out 71.83 APE67-dihe-in -66.94, -16.94 -38.52, -57.04 APE12-dist-in 8.161 APE11-dist-in 10.454 APE10-dist-in 5.38 APE9-dist-in 3.753 None TPO39,TPO198 TPO39,TPO198 XRAY 1.75 0.178 0.216 A 274 268 0 0 0 0 [[43, 293]] 1.0 6gr8 CAMK_AURKC_HUMAN CAMK 1.1e-80 276.7 1 256 256 183 184 185 187 189 72 91 95 163 165 164 166 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
CAMK SIK3 SIK3_HUMAN 8R4UA Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.114 15.718 BLAminus DFGAsp-rot-in -120.83, 177.32 64.3, 69.36 208.49, -19.29 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.71 Saltbr-out 5.071 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.575 APE11-dist-in 10.839 APE10-dist-in 5.2 APE9-dist-in 3.515 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UC Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.064 15.726 BLAminus DFGAsp-rot-in -119.63, 172.69 64.17, 70.56 208.02, -18.54 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.634 Saltbr-out 5.218 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6 APE11-dist-in 10.767 APE10-dist-in 5.18 APE9-dist-in 3.513 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UE Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.17 15.536 BLAminus DFGAsp-rot-in -122.53, 178.95 58.14, 68.61 208.42, -19.02 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.651 Saltbr-out 5.131 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.534 APE11-dist-in 10.767 APE10-dist-in 5.184 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328 317 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UG Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.045 15.697 BLAminus DFGAsp-rot-in -121.26, 171.88 69.65, 69.3 209.13, -19.4 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.772 Saltbr-out 5.165 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.813 APE10-dist-in 5.192 APE9-dist-in 3.424 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CMGC DYRK1A DYR1A_HUMAN 6EIJC Q13627 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus DFGAsp-rot-in -119.52, 178.29 74.66, 62.43 194.0, 15.07 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC MAPK1 MK01_HUMAN 6OPIA P28482 10 356 360.0 N0V:60401 Type1.5_Front None DFGin 6.816 16.494 BLAminus DFGAsp-rot-in -135.48, 169.13 71.03, 93.69 199.93, -40.15 -111.04, 34.22 293.24, 78.08 -67.49, -29.15 in-in in 9.892 Saltbr-in 3.054 HRD-in -72.72, -50.31 76.41, -2.79 in-in-none SNCiin in-none ActLoopNT-in 2.808 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.69 APE8-rot-in 306.85 APE67-dihe-in -62.81, -15.96 -67.99, -45.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO185,PTR187 TPO185,PTR187 XRAY 3.0 0.189 0.26 A 354 326 17 0 0 12 [[25, 313]] 1.0 6opi CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4QTAA P28482 10 358 360.0 38Z:411 Type1.5_Front Inactive DFGin 6.901 16.419 BLAminus DFGAsp-rot-in -127.54, 173.07 71.53, 87.6 197.52, -9.12 -104.51, 22.85 289.22, 73.36 -66.57, -25.44 in-in in 9.627 Saltbr-in 2.647 HRD-in -72.05, -50.52 77.72, -5.81 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.19 APE8-rot-out 186.7 APE67-dihe-in -78.23, -10.32 -106.34, 7.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.45 0.16 0.191 A 361 335 14 0 0 14 [[25, 313]] 1.0 4qta CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9DA P28482 8 357 360.0 ER8:406 Type1.5_Front Inactive DFGin 6.832 16.417 BLAminus DFGAsp-rot-in -130.82, 177.58 62.78, 85.24 198.93, -5.3 -103.76, 20.35 283.71, 79.73 -63.11, -28.56 in-in in 9.944 Saltbr-in 2.634 HRD-in -73.65, -52.91 75.39, 8.67 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.6, -41.14 APE9-dihe-na -67.27, 166.02 APE8-dihe-in -67.59, 131.6 APE8-rot-in 309.39 APE67-dihe-in -67.26, -16.88 -58.97, -46.53 APE12-dist-out 14.47 APE11-dist-in 11.169 APE10-dist-in 7.005 APE9-dist-in 4.162 None None CME161 XRAY 1.8 0.169 0.223 A 368 346 0 0 0 0 [[25, 313]] 1.0 6g9d CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9HA P28482 11 357 360.0 ERW:405 Type1.5_Front Inactive DFGin 6.863 16.193 BLAminus DFGAsp-rot-in -129.54, 176.24 67.51, 84.59 190.02, -0.52 -100.67, 23.24 285.23, 76.32 -64.98, -24.84 out-in out 10.126 Saltbr-in 2.649 HRD-in -73.48, -50.99 74.79, 0.78 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.85, -36.75 APE9-dihe-na -71.44, 161.71 APE8-dihe-in -53.41, 125.25 APE8-rot-in 311.99 APE67-dihe-in -63.79, -17.26 -57.75, -47.59 APE12-dist-out 14.502 APE11-dist-in 11.198 APE10-dist-in 7.038 APE9-dist-in 4.328 None None CME161 XRAY 1.73 0.164 0.213 A 368 344 0 0 0 0 [[25, 313]] 1.0 6g9h CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9JA P28482 8 357 360.0 ERK:403 Type1.5_Front Inactive DFGin 6.852 16.45 BLAminus DFGAsp-rot-in -129.62, 174.38 66.65, 81.52 195.47, 2.95 -99.73, 19.69 286.36, 76.45 -66.94, -21.09 in-in in 9.657 Saltbr-in 2.72 HRD-in -69.57, -51.16 71.71, 3.51 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -94.41, -41.74 APE9-dihe-na -65.68, 165.5 APE8-dihe-in -68.67, 127.92 APE8-rot-in 310.31 APE67-dihe-in -68.75, -18.58 -53.05, -47.45 APE12-dist-out 14.709 APE11-dist-in 11.229 APE10-dist-in 7.162 APE9-dist-in 4.357 None None CME127,CME161,CME166 XRAY 1.98 0.162 0.212 A 368 350 0 0 0 0 [[25, 313]] 1.0 6g9j CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9KA P28482 11 357 360.0 ESK:404 Type1.5_Front Inactive DFGin 6.869 16.501 BLAminus DFGAsp-rot-in -127.44, 173.71 64.58, 89.87 195.69, 1.58 -103.62, 17.25 282.92, 76.11 -73.44, -14.72 in-in in 9.738 Saltbr-in 2.645 HRD-in -66.45, -52.24 73.55, 2.38 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.11, -41.06 APE9-dihe-na -64.16, 170.62 APE8-dihe-in -77.68, 128.75 APE8-rot-in 308.66 APE67-dihe-in -63.28, -19.27 -55.77, -50.47 APE12-dist-out 14.968 APE11-dist-in 11.461 APE10-dist-in 7.308 APE9-dist-in 4.294 None None CME127,CME161 XRAY 1.94 0.164 0.223 A 368 345 0 0 0 0 [[25, 313]] 1.0 6g9k CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9NA P28482 11 357 360.0 ESN:407 Type1.5_Front Inactive DFGin 7.133 16.526 BLAminus DFGAsp-rot-in -124.73, 175.13 63.57, 85.94 198.01, -15.91 -99.62, 16.39 282.24, 77.66 -74.35, -19.57 out-in out 10.165 Saltbr-in 2.75 HRD-in -70.0, -50.46 74.7, 7.06 in-in-out SNCiio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -65.54, 147.38 APE9-dihe-na 67.51, -176.26 APE8-dihe-in -97.0, 144.29 APE8-rot-in 289.97 APE67-dihe-in -64.18, -20.4 -49.42, -51.94 APE12-dist-in 13.633 APE11-dist-in 11.722 APE10-dist-out 9.01 APE9-dist-in 3.21 None None CME161 XRAY 1.76 0.168 0.218 A 368 345 0 0 0 0 [[25, 313]] 1.0 6g9n CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GDMA P28482 8 356 360.0 F3Z:404 Type1.5_Front Inactive DFGin 6.841 16.526 BLAminus DFGAsp-rot-in -126.95, 171.54 65.54, 87.24 199.32, -16.29 -101.62, 18.17 285.3, 73.79 -62.71, -23.55 in-in in 9.642 Saltbr-in 2.691 HRD-in -73.55, -51.55 74.53, 5.94 in-in-out SNCiio in-out ActLoopNT-in 2.769 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.91, -41.51 APE9-dihe-na -60.95, 166.12 APE8-dihe-in -74.95, 131.2 APE8-rot-in 307.5 APE67-dihe-in -60.9, -19.09 -57.69, -50.8 APE12-dist-out 14.652 APE11-dist-in 11.274 APE10-dist-in 7.213 APE9-dist-in 4.107 None None CME65,CME161,CME166,CME254 XRAY 1.91 0.185 0.243 A 368 345 0 0 0 0 [[25, 313]] 1.0 6gdm CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GE0A P28482 11 357 360.0 EVQ:406 Type1.5_Front Inactive DFGin 6.807 16.409 BLAminus DFGAsp-rot-in -125.01, 178.42 65.88, 86.44 192.64, -0.22 -104.81, 21.96 285.23, 73.29 -68.51, -20.31 in-in in 9.852 Saltbr-in 2.616 HRD-in -69.56, -50.3 73.32, 2.78 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.29, -38.81 APE9-dihe-na -61.85, 160.75 APE8-dihe-in -56.8, 124.98 APE8-rot-in 313.47 APE67-dihe-in -60.01, -18.82 -53.88, -51.43 APE12-dist-out 14.586 APE11-dist-in 11.277 APE10-dist-in 7.386 APE9-dist-in 4.33 None None CME127,CME161 XRAY 1.82 0.165 0.21 A 368 345 0 0 0 0 [[25, 313]] 1.0 6ge0 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GJDA P28482 10 357 360.0 F0E:411 Type1.5_Front Inactive DFGin 6.71 16.462 BLAminus DFGAsp-rot-in -129.58, 174.41 70.7, 91.35 194.5, -12.77 -105.73, 20.26 284.72, 79.09 -64.64, -25.49 in-in in 9.62 Saltbr-in 2.671 HRD-in -72.09, -52.59 71.97, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.798 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.38, -38.44 APE9-dihe-na -62.52, 167.01 APE8-dihe-in -77.48, 126.95 APE8-rot-in 303.11 APE67-dihe-in -62.52, -19.79 -59.63, -41.94 APE12-dist-out 14.402 APE11-dist-in 11.242 APE10-dist-in 6.98 APE9-dist-in 4.093 None None CME161 XRAY 1.58 0.169 0.21 A 368 342 0 0 0 0 [[25, 313]] 1.0 6gjd CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7AUVA P28482 11 357 360.0 RYW:405 Type1.5_Front Inactive DFGin 7.023 16.575 BLAminus DFGAsp-rot-in -127.45, 177.69 56.53, 84.41 199.63, -13.51 -94.89, 19.78 285.74, 75.17 -78.04, -13.36 out-in out 10.23 Saltbr-in 2.72 HRD-in -72.53, -48.67 70.65, 1.51 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -92.76, -42.85 APE9-dihe-na -53.93, 163.97 APE8-dihe-in -75.48, 124.43 APE8-rot-in 308.53 APE67-dihe-in -70.04, -12.97 -52.3, -46.84 APE12-dist-out 14.989 APE11-dist-in 11.59 APE10-dist-in 7.384 APE9-dist-in 4.228 None None CME161 XRAY 1.76 0.17 0.229 A 368 347 0 0 0 0 [[25, 313]] 1.0 7auv CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQQA P28482 11 356 360.0 UMN:406 Type1.5_Front Inactive DFGin 6.918 16.492 BLAminus DFGAsp-rot-in -130.12, 174.13 62.32, 86.15 195.1, -0.73 -100.4, 23.58 286.24, 72.55 -69.75, -20.62 in-in in 9.469 Saltbr-in 2.678 HRD-in -65.77, -47.18 66.3, 4.45 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -99.75, -32.6 APE9-dihe-na -69.61, 163.37 APE8-dihe-in -60.6, 124.16 APE8-rot-in 315.24 APE67-dihe-in -60.72, -19.47 -52.29, -51.54 APE12-dist-out 14.8 APE11-dist-in 11.374 APE10-dist-in 7.402 APE9-dist-in 4.344 None None CME161 XRAY 1.943 0.177 0.228 A 368 342 0 0 0 0 [[25, 313]] 1.0 7nqq CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQWA P28482 11 356 360.0 UNW:405 Type1.5_Front Inactive DFGin 6.816 16.419 BLAminus DFGAsp-rot-in -126.85, 178.18 67.17, 79.44 189.51, 12.54 -98.87, 21.06 284.86, 74.28 -63.45, -23.61 in-in in 9.783 Saltbr-in 2.511 HRD-in -71.96, -49.6 74.37, 1.07 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.4, -37.94 APE9-dihe-na -67.38, 158.88 APE8-dihe-in -52.66, 123.57 APE8-rot-in 311.73 APE67-dihe-in -63.22, -17.02 -54.57, -47.98 APE12-dist-out 14.626 APE11-dist-in 11.263 APE10-dist-in 7.186 APE9-dist-in 4.38 None None CME161 XRAY 1.775 0.167 0.206 A 368 346 0 0 0 0 [[25, 313]] 1.0 7nqw CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR5A P28482 11 357 360.0 UOH:405 Type1.5_Front Inactive DFGin 7.142 16.516 BLAminus DFGAsp-rot-in -128.99, 175.71 60.33, 87.75 197.73, -15.01 -101.3, 22.07 283.66, 79.18 -76.03, -20.46 out-in out 10.13 Saltbr-in 2.688 HRD-in -71.53, -48.61 67.4, 6.67 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -66.22, 143.49 APE9-dihe-na 70.29, 179.11 APE8-dihe-in -86.54, 137.23 APE8-rot-in 294.6 APE67-dihe-in -64.14, -18.44 -44.13, -48.47 APE12-dist-in 13.395 APE11-dist-in 11.517 APE10-dist-out 9.146 APE9-dist-in 3.117 None None CME161 XRAY 1.766 0.176 0.223 A 368 342 0 0 0 0 [[25, 313]] 1.0 7nr5 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR8A P28482 11 356 360.0 UOE:408 Type1.5_Front Inactive DFGin 6.789 16.622 BLAminus DFGAsp-rot-in -131.19, 173.71 59.31, 84.45 197.74, -15.45 -94.57, 22.79 284.69, 71.84 -65.62, -20.38 in-in in 9.992 Saltbr-in 2.554 HRD-in -71.25, -47.16 78.03, -4.67 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.57, -40.56 APE9-dihe-na -62.09, 161.08 APE8-dihe-in -53.56, 123.22 APE8-rot-in 309.14 APE67-dihe-in -64.63, -17.01 -54.92, -46.72 APE12-dist-out 14.771 APE11-dist-in 11.432 APE10-dist-in 7.445 APE9-dist-in 4.449 None None CME161 XRAY 1.627 0.173 0.213 A 368 346 0 0 0 0 [[25, 313]] 1.0 7nr8 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR9A P28482 11 355 360.0 UOW:402 Type1.5_Front Inactive DFGin 7.179 16.445 BLAminus DFGAsp-rot-in -121.95, 178.87 51.29, 96.32 189.39, -17.12 -108.0, 26.49 285.39, 78.02 -83.88, -16.22 out-in out 10.206 Saltbr-in 3.273 HRD-in -66.46, -47.39 67.01, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -152.12, -19.83 APE9-dihe-na -57.71, 157.85 APE8-dihe-in -80.51, 146.4 APE8-rot-in 299.55 APE67-dihe-in -65.28, -14.73 -65.27, -45.43 APE12-dist-out 14.665 APE11-dist-in 11.277 APE10-dist-in 7.298 APE9-dist-in 3.56 None None CME161 XRAY 1.906 0.248 0.308 A 368 335 0 0 0 0 [[25, 313]] 1.0 7nr9 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3DA6A P53779 46 401 464.0 BZ9:1 Type1.5_Front Inactive DFGin 3.929 14.747 ABAminus DFGAsp-rot-out -106.52, -2.79 -134.69, 178.18 74.66, -45.22 -120.78, 7.15 305.58, 102.19 77.8, -154.0 out-out out 11.165 Saltbr-out 7.563 HRD-in -66.32, -64.11 78.04, -4.14 out-out-out SNCooo out-out ActLoopNT-out 7.545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 119.26 APE9-dihe-na -81.12, 139.86 APE8-dihe-in -90.77, 119.11 APE8-rot-out 151.47 APE67-dihe-in -57.67, -20.17 -106.88, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.829 None None None XRAY 2.0 0.259 0.32 A 364 328 12 0 0 10 [[64, 359]] 1.0 3da6 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4U79A P53779 44 400 464.0 3EL:501 Type1.5_Front Inactive DFGin 4.272 14.867 ABAminus DFGAsp-rot-out -89.42, -22.99 -142.11, 177.19 69.97, 42.48 -106.92, 6.69 291.05, 92.1 89.72, -154.87 out-out out 10.185 Saltbr-out 7.925 HRD-in -77.27, -59.41 68.42, 2.43 out-out-out SNCooo out-out ActLoopNT-out 6.442 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.02 APE8-dihe-in -101.3, 127.09 APE8-rot-out 123.68 APE67-dihe-in -52.45, -19.16 -120.61, -1.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.63 None None None XRAY 2.23 0.218 0.249 A 364 337 13 0 0 11 [[64, 359]] 1.0 4u79 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK3 MK03_HUMAN 4QTBA P27361 24 374 379.0 38Z:418 Type1.5_Front Inactive DFGin 6.963 16.192 BLAminus DFGAsp-rot-in -128.63, 172.06 72.12, 87.31 200.35, -19.7 -104.64, 23.58 286.23, 74.76 -64.07, -28.14 in-in in 9.638 Saltbr-in 2.654 HRD-in -72.11, -54.76 73.09, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -93.95, -29.12 APE9-dihe-na -67.78, 160.1 APE8-dihe-in -53.91, 125.98 APE8-rot-in 310.28 APE67-dihe-in -65.26, -17.27 -52.54, -50.1 APE12-dist-out 14.155 APE11-dist-in 10.804 APE10-dist-in 6.843 APE9-dist-in 4.412 None None None XRAY 1.4 0.148 0.175 A 380 351 0 0 0 0 [[42, 330]] 1.0 4qtb CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 4QTBB P27361 27 374 379.0 38Z:412 Type1.5_Front Inactive DFGin 6.989 16.095 BLAminus DFGAsp-rot-in -131.38, 169.9 76.01, 86.99 200.97, -17.02 -105.18, 21.27 288.36, 77.86 -59.51, -32.2 in-in in 9.594 Saltbr-in 2.709 HRD-in -72.51, -53.5 77.51, 5.81 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -90.9, -27.9 APE9-dihe-na -67.55, 157.04 APE8-dihe-in -54.84, 126.95 APE8-rot-in 308.82 APE67-dihe-in -67.72, -16.58 -53.94, -47.75 APE12-dist-out 14.188 APE11-dist-in 10.858 APE10-dist-in 7.082 APE9-dist-in 4.411 None None None XRAY 1.4 0.148 0.175 B 380 348 0 0 0 0 [[42, 330]] 1.0 4qtb CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK7 MK07_HUMAN 6HKNA Q13164 54 393 816.0 G9E:1001 Type1.5_Front Inactive DFGin 6.803 16.175 BLAminus DFGAsp-rot-out -129.91, -177.31 56.69, 71.23 287.82, -19.93 -86.37, 9.05 284.58, 84.05 -53.54, -30.22 out-out out 10.182 Saltbr-out 5.893 HRD-in -68.18, -48.7 72.35, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -68.45, 121.21 APE9-dihe-na 64.95, -147.27 APE8-dihe-in -100.08, 133.81 APE8-rot-in 310.44 APE67-dihe-in -63.59, -21.47 -60.08, -43.48 APE12-dist-out 14.878 APE11-dist-in 11.693 APE10-dist-in 7.73 APE9-dist-in 4.463 None None None XRAY 2.33 0.209 0.249 A 340 333 7 0 0 0 [[55, 347]] 1.0 6hkn CMGC_MAPK7_HUMAN CMGC 6e-82 281.4 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 6HKMA Q13164 54 395 816.0 G92:1001 Type1.5_Front Inactive DFGin 6.803 15.84 BLAminus DFGAsp-rot-out -123.75, -172.09 56.25, 77.83 302.45, 79.5 -101.07, 16.04 286.41, 85.42 -62.88, -24.07 in-out in 9.919 Saltbr-out 4.891 HRD-in -70.02, -49.84 71.12, 8.12 out-in-out SNCoio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -78.44, 115.75 APE9-dihe-na 70.91, -145.41 APE8-dihe-in -108.32, 133.47 APE8-rot-out 174.14 APE67-dihe-in -68.29, -14.88 -60.97, -41.94 APE12-dist-out 14.71 APE11-dist-in 11.45 APE10-dist-in 7.56 APE9-dist-in 4.281 None None None XRAY 2.47 0.222 0.28 A 347 327 15 0 0 2 [[55, 347]] 1.0 6hkm CMGC_MAPK7_HUMAN CMGC 6.5e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
OTHER ERN1 ERN1_HUMAN 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.559 15.899 BLAminus DFGAsp-rot-out -140.85, 172.03 60.0, 89.13 289.15, -33.3 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.584 Saltbr-out 7.056 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431 366 31 0 0 21 [[571, 832]] 1.0 6w3e OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.489 15.205 BLAminus DFGAsp-rot-out -139.2, -157.42 53.89, 65.22 274.02, 87.33 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.188 Saltbr-out 12.042 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.114 APE10-dist-in 7.347 APE9-dist-out 9.016 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.499 14.81 BLAminus DFGAsp-rot-in -137.56, -175.69 71.07, 82.79 202.33, -9.91 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.069 Saltbr-out 11.269 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.721 APE11-dist-out 7.141 APE10-dist-out 10.097 APE9-dist-in 3.899 None None None XRAY 2.43 0.184 0.251 A 448 403 0 0 0 0 [[571, 832]] 1.0 8uvl OTHER_ERN1_HUMAN CAMK 3.5e-34 124.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 6Z5AA Q8TF76 465 798 798.0 Q8B:60807 Type1.5_Front Inactive DFGin 4.746 13.158 BLAminus DFGAsp-rot-in -130.52, 170.23 77.78, 97.19 195.47, -11.53 -110.55, 22.86 309.49, 126.33 -50.19, -42.61 out-out out 10.928 Saltbr-out 6.049 HRD-na-N -69.87, -51.48 73.76, 2.92 out-in-na SNCoia in-na ActLoopNT-in 2.957 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.05, 16.57 APE9-dihe-na -70.55, 162.23 APE8-dihe-na -152.03, 159.2 APE8-rot-na 218.93 APE67-dihe-na -157.88, 144.9 96.43, 3.83 APE12-dist-na 9.408 APE11-dist-na 13.313 APE10-dist-na 16.953 APE9-dist-na 12.968 None None None XRAY 1.55 0.157 0.182 A 357 334 0 0 0 0 [[484, 797]] 1.0 6z5a OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 6TNBA P33981 517 794 857.0 8QW:901 Type1.5_Front Inactive DFGin 3.852 15.094 ABAminus DFGAsp-rot-out -120.69, -13.19 -153.82, 168.98 72.21, -21.11 -122.43, 7.93 296.97, 146.25 65.5, 17.91 out-out out 11.011 Saltbr-out 8.542 HRD-in -60.06, -45.03 76.67, -3.67 out-out-out SNCooo out-out ActLoopNT-out 12.114 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 47.02 APE8-dihe-in -74.89, 162.5 APE8-rot-none 999.0 APE67-dihe-in -76.36, -29.64 -145.32, 10.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.114 None TPO686 TPO686 XRAY 2.65 0.215 0.262 A 294 252 26 0 0 15 [[525, 791]] 1.0 6tnb OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N9SA P33981 519 794 857.0 8QW:60901 Type1.5_Front Inactive DFGin 3.866 14.796 ABAminus DFGAsp-rot-out -103.91, -21.18 -148.36, 167.12 78.16, -46.47 -113.73, -1.29 297.53, 126.79 78.88, 15.58 out-out out 10.96 Saltbr-out 9.124 HRD-in -76.88, -53.0 67.73, 3.84 out-out-out SNCooo out-out ActLoopNT-out 11.817 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na 176.56, 127.56 APE9-dihe-na 70.2, 2.51 APE8-dihe-in -61.92, 151.57 APE8-rot-none 999.0 APE67-dihe-in -61.07, -20.0 -114.51, -10.18 APE12-dist-out 19.555 APE11-dist-out 17.191 APE10-dist-out 14.162 APE9-dist-out 10.05 None TPO686 TPO686 XRAY 2.3 0.194 0.245 A 313 257 19 0 0 7 [[525, 791]] 1.0 5n9s OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K7 MP2K7_HUMAN 7OVIA O14733 102 402 419.0 2GI:60501 Type1.5_Front Inactive DFGin 4.755 13.599 BLAplus DFGAsp-rot-out -140.91, 171.28 50.96, 52.63 291.6, -38.89 -104.5, 0.42 42.65, 71.15 -92.35, -151.25 na-na na 9.793 Saltbr-na 8.346 HRD-out -95.23, 128.06 -114.34, -2.31 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.25 A 318 262 39 0 0 23 [[120, 380]] 1.0 7ovi STE_MAP2K7_HUMAN STE 2.8e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVJA O14733 102 403 419.0 24N:60501 Type1.5_Front Inactive DFGin 5.238 14.04 BLBplus DFGAsp-rot-out -149.66, 173.75 53.03, 68.8 281.82, -31.25 -120.16, 126.9 30.41, 81.15 125.32, 999.0 na-na na 9.497 Saltbr-na 8.403 HRD-in -63.57, -57.01 68.81, 21.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.2 APE8-dihe-in -71.05, 126.52 APE8-rot-na 187.98 APE67-dihe-in -67.38, -26.76 -67.11, -24.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.191 None None None XRAY 2.35 0.204 0.244 A 318 276 26 0 0 15 [[120, 380]] 1.0 7ovj STE_MAP2K7_HUMAN STE 2.8e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.276 14.073 None DFGAsp-rot-in -91.61, -76.02 -109.31, 164.08 205.62, -36.22 -125.38, 999.0 315.5, 111.59 999.0, 999.0 na-na na 9.927 Saltbr-na 8.349 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318 265 35 0 0 19 [[120, 380]] 1.0 6ib2 STE_MAP2K7_HUMAN STE 3.2e-80 275.2 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE PAK1 PAK1_HUMAN 5DFPA Q13153 249 541 545.0 59U:601 Type1.5_Front Inactive DFGin 7.083 16.69 BLAminus DFGAsp-rot-in -140.33, 175.32 61.17, 77.14 201.86, -19.09 -92.35, 18.95 281.32, 71.97 -52.66, -30.78 out-none out 10.13 Saltbr-none 999.0 HRD-in -72.71, -47.47 77.58, -9.24 none-in-in SNCnii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.23, -24.32 APE9-dihe-na -78.24, 174.02 APE8-dihe-in -76.36, 125.32 APE8-rot-in 314.95 APE67-dihe-in -61.02, -19.58 -40.67, -55.78 APE12-dist-in 8.892 APE11-dist-in 11.038 APE10-dist-in 5.024 APE9-dist-in 3.405 K299R TPO423 TPO423 XRAY 2.2 0.193 0.246 A 297 293 0 0 0 0 [[270, 521]] 1.0 5dfp STE_PAK1_HUMAN STE 7.5e-95 323.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.32 10.343 BBAminus DFGAsp-rot-in -126.87, -173.24 -145.98, 95.31 190.47, -25.67 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303 272 19 0 0 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.363 10.386 BBAminus DFGAsp-rot-in -130.09, -171.07 -147.42, 95.57 190.72, -23.79 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.713 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.404 None None None XRAY 2.6 0.224 0.255 B 303 275 17 0 0 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK10 STK10_HUMAN 7QGPA O94804 23 313 968.0 DJ8:401 Type1.5_Front Inactive DFGin 6.63 15.647 BLBminus DFGAsp-rot-in -137.41, 176.17 64.63, 46.3 206.91, 12.85 -55.04, 138.14 280.95, 68.0 -53.28, 137.64 in-out in 8.416 Saltbr-out 10.651 HRD-in -69.38, -55.58 84.71, -10.94 out-out-out SNCooo out-out ActLoopNT-out 11.032 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -131.79, 8.52 APE9-dihe-na 91.31, 163.78 APE8-dihe-in -62.99, 130.71 APE8-rot-in 298.17 APE67-dihe-out -58.73, -25.46 -85.93, 65.94 APE12-dist-in 12.317 APE11-dist-in 13.564 APE10-dist-out 8.716 APE9-dist-out 11.288 None None None XRAY 1.9 0.201 0.237 A 302 288 3 0 0 0 [[36, 294]] 1.0 7qgp STE_STK10_HUMAN STE 4.8e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 7B30A Q9Y6E0 26 301 443.0 59T:60401 Type1.5_Front Inactive DFGin 5.998 16.341 BLBminus DFGAsp-rot-out -142.66, 171.86 53.27, 62.4 279.35, -7.02 -55.16, 145.73 286.02, 54.35 -77.45, 152.93 out-out out 10.152 Saltbr-out 5.155 HRD-in -71.84, -49.63 80.65, -3.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.97 APE8-rot-out 199.34 APE67-dihe-in -62.34, -30.7 -96.14, -7.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.178 0.196 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b30 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B31A Q9Y6E0 26 301 443.0 SQ8:60401 Type1.5_Front Inactive DFGin 5.963 16.341 BLBminus DFGAsp-rot-out -140.7, 175.65 52.28, 60.52 276.6, -7.1 -54.42, 142.35 285.4, 61.46 -75.74, 160.64 out-out out 10.162 Saltbr-out 5.212 HRD-in -69.31, -49.87 81.3, -4.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.03 APE8-rot-out 170.11 APE67-dihe-in -67.52, -27.96 -93.98, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.178 0.212 A 306 260 16 0 0 15 [[36, 286]] 1.0 7b31 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B32A Q9Y6E0 26 301 443.0 SQQ:60401 Type1.5_Front Inactive DFGin 5.994 16.506 BLBminus DFGAsp-rot-out -139.7, 173.68 52.58, 62.82 279.25, -8.3 -58.11, 145.21 283.84, 55.87 -74.74, 156.53 out-out out 10.247 Saltbr-out 5.257 HRD-in -70.06, -50.26 83.03, -8.41 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.41 APE8-rot-out 171.24 APE67-dihe-in -64.92, -27.84 -92.4, -6.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.176 0.203 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b32 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B33A Q9Y6E0 26 301 443.0 SQE:60905 Type1.5_Front Inactive DFGin 5.91 16.194 BLBminus DFGAsp-rot-out -141.17, 175.88 52.44, 59.58 279.1, -12.74 -53.5, 142.51 285.89, 62.08 -74.39, 158.17 out-out out 10.226 Saltbr-out 5.306 HRD-in -70.12, -49.24 81.27, -6.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.19 APE8-rot-out 184.46 APE67-dihe-in -66.19, -27.5 -93.44, -7.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.182 0.208 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b33 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B34A Q9Y6E0 26 301 443.0 SQK:60608 Type1.5_Front Inactive DFGin 5.982 16.334 BLBminus DFGAsp-rot-out -147.82, -179.56 47.7, 64.7 275.56, -11.15 -58.67, 144.27 284.06, 64.99 -79.61, 160.22 out-out out 10.231 Saltbr-out 5.075 HRD-in -70.42, -53.51 88.4, -7.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.81 APE8-rot-out 203.11 APE67-dihe-in -61.35, -31.31 -94.67, -11.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.191 0.215 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b34 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35A Q9Y6E0 26 301 443.0 SQB:60401 Type1.5_Front Inactive DFGin 5.824 16.212 BLBminus DFGAsp-rot-out -141.79, 178.75 47.82, 66.16 272.95, -10.96 -66.86, 142.85 279.77, 46.45 -79.99, 160.94 out-out out 10.147 Saltbr-out 5.385 HRD-in -75.69, -45.29 76.32, -1.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.05 APE8-rot-out 51.17 APE67-dihe-in -63.93, -31.26 -96.22, 7.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.263 A 306 261 15 0 0 15 [[36, 286]] 1.0 7b35 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35B Q9Y6E0 26 301 443.0 SQB:60401 Type1.5_Front Inactive DFGin 5.949 16.202 BLBminus DFGAsp-rot-out -142.08, 177.83 50.7, 59.46 271.7, -15.31 -61.4, 147.78 284.16, 55.56 -80.3, 162.91 out-out out 10.12 Saltbr-out 5.12 HRD-in -73.73, -40.61 75.9, -3.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.95 APE8-rot-out 172.46 APE67-dihe-in -66.86, -22.7 -94.71, -1.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.263 B 306 261 15 0 0 15 [[36, 286]] 1.0 7b35 STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZJB Q9Y6E0 26 301 443.0 SJX:60401 Type1.5_Front Inactive DFGin 5.978 16.498 BLBminus DFGAsp-rot-out -134.62, -178.8 42.57, 68.83 299.39, -79.84 -59.18, 156.04 283.69, 69.22 -85.7, 141.9 out-out out 10.293 Saltbr-out 5.207 HRD-in -67.7, -47.74 83.43, -18.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.33 APE8-rot-in 295.22 APE67-dihe-in -62.19, -30.29 -95.02, -12.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.185 0.25 B 306 261 15 0 0 15 [[36, 286]] 1.0 8bzj STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRA Q9Y6E0 26 301 443.0 VYN:60401 Type1.5_Front Inactive DFGin 5.781 16.292 BLBminus DFGAsp-rot-out -139.31, 171.02 54.18, 66.37 284.86, -56.76 -60.4, 145.29 286.55, 53.64 -76.98, 163.2 out-out out 10.244 Saltbr-out 5.329 HRD-in -64.82, -50.81 83.77, -6.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.94 APE8-rot-out 186.72 APE67-dihe-in -63.37, -30.26 -94.36, -2.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.181 0.217 A 306 261 15 0 0 15 [[36, 286]] 1.0 8qlr STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRB Q9Y6E0 26 301 443.0 VYN:60401 Type1.5_Front Inactive DFGin 5.739 16.377 BLBminus DFGAsp-rot-out -139.86, 177.24 47.6, 68.2 287.82, -64.78 -64.36, 146.73 282.24, 52.97 -75.84, 163.34 out-out out 10.251 Saltbr-out 5.252 HRD-in -68.7, -49.83 79.32, -3.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.74 APE8-rot-out 167.72 APE67-dihe-in -61.97, -27.51 -94.87, 0.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.181 0.217 B 306 259 17 0 0 15 [[36, 286]] 1.0 8qlr STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLSA Q9Y6E0 26 301 443.0 VYH:60401 Type1.5_Front Inactive DFGin 5.681 16.179 BLBminus DFGAsp-rot-out -139.23, 174.31 56.75, 63.77 290.26, -67.58 -56.08, 144.93 290.16, 67.75 -77.65, 157.52 out-out out 10.178 Saltbr-out 5.276 HRD-in -68.48, -51.67 82.32, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.2 APE8-rot-out 176.47 APE67-dihe-in -65.65, -27.09 -96.29, -4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.61 0.151 0.184 A 306 261 15 0 0 15 [[36, 286]] 1.0 8qls STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLTA Q9Y6E0 25 301 443.0 VZ2:60401 Type1.5_Front Inactive DFGin 5.789 16.276 BLBminus DFGAsp-rot-out -138.52, 170.04 55.04, 64.79 288.0, -65.16 -59.22, 147.63 285.87, 54.67 -80.11, 162.03 out-out out 10.123 Saltbr-out 5.238 HRD-in -67.15, -49.85 79.68, -8.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.14 APE8-rot-out 188.98 APE67-dihe-in -61.86, -29.94 -97.55, -6.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.47 0.153 0.176 A 306 261 16 0 0 15 [[36, 286]] 1.0 8qlt STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 7B36A Q9P289 18 300 416.0 59T:703 Type1.5_Front Inactive DFGin 5.918 16.497 BLBminus DFGAsp-rot-out -143.98, 170.7 56.84, 62.11 272.78, -5.98 -60.85, 154.55 283.92, 44.19 -84.52, 163.38 out-out out 10.529 Saltbr-out 5.434 HRD-in -65.72, -54.18 91.14, -9.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.53 APE8-dihe-in -102.71, 115.66 APE8-rot-out 39.32 APE67-dihe-in -69.82, -27.39 -95.85, 15.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.835 None None None XRAY 2.107 0.203 0.244 A 301 268 15 0 0 14 [[24, 274]] 1.0 7b36 STE_STK26_HUMAN STE 3.6e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus DFGAsp-rot-in -134.39, 177.59 74.52, 87.23 200.43, -15.44 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3.1e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL MAP3K20 M3K20_HUMAN 7YAWB Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 6.061 12.887 BLAplus DFGAsp-rot-in -112.26, 159.46 66.47, 30.72 211.28, 36.86 -77.06, -4.03 46.81, 82.8 -112.18, 3.53 out-out out 16.198 Saltbr-out 14.385 HRD-in -68.93, -58.68 76.93, -11.19 out-out-out SNCooo out-out ActLoopNT-out 5.841 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.67, -41.74 APE9-dihe-na -72.55, 0.42 APE8-dihe-out -131.57, -4.4 APE8-rot-out 77.42 APE67-dihe-in -62.57, -21.79 -53.81, -31.98 APE12-dist-out 14.667 APE11-dist-out 14.027 APE10-dist-out 18.493 APE9-dist-out 12.46 None None None XRAY 2.1 0.208 0.243 B 310 291 1 0 0 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL MAP3K20 M3K20_HUMAN 7YAWC Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 5.677 12.984 BLAplus DFGAsp-rot-in -105.78, 161.9 66.78, 23.82 199.54, 49.64 -68.46, -14.89 48.8, 88.46 -104.69, -15.53 out-out out 16.089 Saltbr-out 16.095 HRD-in -71.18, -58.92 73.09, -4.85 out-out-out SNCooo out-out ActLoopNT-out 5.616 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -67.62, -51.34 APE9-dihe-na -86.7, 18.29 APE8-dihe-out -115.5, -10.48 APE8-rot-in 308.5 APE67-dihe-in -59.14, -22.29 -53.59, -37.71 APE12-dist-out 14.986 APE11-dist-in 13.949 APE10-dist-out 18.373 APE9-dist-out 12.303 None None None XRAY 2.1 0.208 0.243 C 310 291 1 0 0 1 [[16, 262]] 1.0 7yaw TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL RIPK3 RIPK3_HUMAN 7MONB Q9Y572 5 311 518.0 ZL1:401 Type1.5_Front Inactive DFGin 5.319 12.898 BLBplus DFGAsp-rot-out -139.6, 164.18 56.61, 37.55 284.23, -25.27 -80.29, 166.6 34.44, 92.89 79.72, -103.63 out-out out 11.648 Saltbr-out 7.413 HRD-in -76.18, -40.34 61.78, -4.08 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 97.81, 14.44 APE9-dihe-na -63.58, 158.11 APE8-dihe-out -64.13, -29.56 APE8-rot-in 301.21 APE67-dihe-in -66.2, -17.44 -59.33, -40.24 APE12-dist-out 18.646 APE11-dist-out 21.316 APE10-dist-out 17.042 APE9-dist-out 10.554 C3S,C110A TPO224,SEP227 TPO224,SEP227 XRAY 2.23 0.212 0.26 B 316 285 22 0 0 12 [[21, 285]] 1.0 7mon TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TYR ABL1 ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None DFGAsp-rot-out -68.71, 128.66 -122.3, 46.03 51.01, 2.09 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-na 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None DFGAsp-rot-out -74.12, 129.26 -121.25, 39.81 53.04, -9.3 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-na 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None DFGAsp-rot-out -72.67, 142.35 -137.94, 44.53 59.76, -14.4 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-na 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None DFGAsp-rot-out -69.26, 149.18 -127.32, 25.05 44.91, 11.91 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-na 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 4JOAA Q9UM73 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.651 15.18 ABAminus DFGAsp-rot-in -99.28, -25.44 -116.97, 136.23 188.11, -80.67 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.532 Saltbr-out 7.323 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.099 APE10-dist-na 10.28 APE9-dist-na 8.098 S1281G None None XRAY 2.7 0.253 0.29 A 344 251 41 0 0 9 [[1116, 1385]] 1.0 4joa TYR_ALK_HUMAN TYR 5.1e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 3W2OA P00533 698 1017 1210.0 03P:61101 Type1.5_Front Inactive DFGin 6.063 16.853 BLAminus DFGAsp-rot-in -136.96, -170.56 62.22, 87.75 195.09, -21.25 -101.43, 18.89 291.4, 91.83 -57.44, -26.38 out-out out 10.675 Saltbr-out 8.523 HRD-in -77.47, -53.25 75.27, 2.22 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -73.73, 104.36 APE9-dihe-in -123.36, 141.58 APE8-dihe-in -79.92, 73.45 APE8-rot-na 24.57 APE67-dihe-in -74.19, -6.86 -50.44, -40.99 APE12-dist-na 11.686 APE11-dist-na 11.26 APE10-dist-na 10.559 APE9-dist-na 7.223 T790M,L858R None None XRAY 2.35 0.182 0.216 A 331 304 0 0 0 0 [[712, 970]] 1.0 3w2o TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2PA P00533 698 1018 1210.0 W2P:61101 Type1.5_Front Inactive DFGin 6.166 17.253 BLAminus DFGAsp-rot-in -131.72, -170.04 61.76, 87.11 193.27, -27.38 -100.15, 22.27 288.83, 85.51 -59.78, -24.55 out-out out 10.896 Saltbr-out 9.197 HRD-in -74.33, -49.37 70.61, 3.25 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -98.88, 109.86 APE9-dihe-in -115.54, 146.26 APE8-dihe-in -77.33, 72.71 APE8-rot-na 32.52 APE67-dihe-in -72.04, -9.29 -47.42, -44.04 APE12-dist-na 11.857 APE11-dist-na 11.036 APE10-dist-na 11.483 APE9-dist-na 7.134 T790M,L858R None None XRAY 2.05 0.181 0.206 A 331 307 0 0 0 0 [[712, 970]] 1.0 3w2p TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2QA P00533 698 1017 1210.0 HKI:61101 Type1.5_Front Inactive DFGin 6.184 16.72 BLAminus DFGAsp-rot-in -130.59, -173.46 61.6, 82.75 194.61, -17.8 -98.16, 22.05 287.41, 85.18 -65.26, -18.03 out-out out 10.536 Saltbr-out 5.753 HRD-in -77.64, -48.42 70.13, 4.48 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.12, 121.01 APE9-dihe-in -124.15, 141.54 APE8-dihe-in -80.25, 75.51 APE8-rot-na 32.95 APE67-dihe-in -72.98, -8.46 -42.37, -46.09 APE12-dist-na 12.571 APE11-dist-na 10.333 APE10-dist-na 10.606 APE9-dist-na 7.01 T790M,L858R None None XRAY 2.2 0.177 0.2 A 331 306 0 0 0 0 [[712, 970]] 1.0 3w2q TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKC P00533 701 1014 1210.0 TQA:1301 Type1.5_Front Inactive DFGin 4.108 14.307 BLBplus DFGAsp-rot-out -128.74, 170.35 57.84, 42.31 288.35, 8.06 -80.67, 146.74 56.84, 84.42 73.11, 52.84 out-out out 13.687 Saltbr-out 13.168 HRD-in -69.35, -57.7 81.97, -4.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -99.43 APE9-dihe-in -140.88, 118.68 APE8-dihe-in -72.34, 69.57 APE8-rot-na 41.21 APE67-dihe-in -76.32, 0.41 -56.53, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.489 APE9-dist-na 8.042 T790M,V948R None None XRAY 2.4 0.219 0.23 C 328 299 15 0 0 15 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNC P00533 701 1014 1210.0 UEJ:1301 Type1.5_Front Inactive DFGin 5.149 14.242 BLBplus DFGAsp-rot-out -125.79, 168.58 69.11, 30.42 286.81, 3.3 -73.13, 126.76 42.33, 95.66 91.61, -9.41 out-out out 13.559 Saltbr-out 12.827 HRD-in -75.25, -56.93 84.93, -23.09 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.4 APE8-dihe-in -83.07, 65.64 APE8-rot-na 32.78 APE67-dihe-in -77.0, -5.94 -52.82, -37.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.347 T790M,V948R None None XRAY 1.76 0.209 0.235 C 328 286 28 0 0 16 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXND P00533 702 1014 1210.0 UEJ:1101 Type1.5_Front Inactive DFGin 5.021 14.15 BLBplus DFGAsp-rot-out -127.07, 163.26 73.25, 22.29 286.6, 3.56 -63.33, 141.68 45.73, 93.45 80.75, -14.01 out-out out 13.653 Saltbr-out 13.598 HRD-in -75.42, -56.41 82.09, -17.01 out-out-none SNCoon out-none ActLoopNT-out 6.661 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.16 APE8-dihe-in -83.51, 70.14 APE8-rot-na 34.07 APE67-dihe-in -73.61, -7.52 -55.72, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.723 T790M,V948R None None XRAY 1.76 0.209 0.235 D 328 292 16 0 0 13 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3A P00533 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus DFGAsp-rot-out -135.94, 169.11 67.48, 22.01 287.05, -58.05 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-none SNCoon out-none ActLoopNT-out 8.667 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8PO3A P00533 706 1001 1210.0 2II:1101 Type1.5_Front Inactive DFGin 5.664 17.494 BLBtrans DFGAsp-rot-out -107.39, 172.75 67.19, 30.39 282.71, -22.83 -61.3, 132.08 163.82, 77.02 76.73, -7.92 out-out out 15.498 Saltbr-out 15.217 HRD-in -73.05, -52.43 81.25, -11.07 out-out-none SNCoon out-none ActLoopNT-out 6.766 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.29 APE8-dihe-in -83.1, 70.29 APE8-rot-na 33.27 APE67-dihe-in -73.75, -3.18 -47.3, -43.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.215 V948R None None XRAY 2.13 0.222 0.269 A 330 279 13 0 0 13 [[712, 970]] 1.0 8po3 TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR FGFR3 FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus DFGAsp-rot-in -138.69, 176.26 64.2, 86.01 192.54, -15.43 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-na 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus DFGAsp-rot-out -108.64, 157.87 56.15, 40.62 295.75, -51.28 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-na 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus DFGAsp-rot-out -109.74, 157.08 55.91, 40.67 296.56, -52.6 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-na 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR HCK HCK_HUMAN 2C0IA P08631 81 526 526.0 L1G:61506 Type1.5_Front Inactive DFGin 6.769 17.744 BLBtrans DFGAsp-rot-out -115.37, 154.0 70.82, 18.12 277.5, -11.55 -65.91, 121.57 184.38, 41.99 105.96, -38.14 out-out out 13.402 Saltbr-out 13.311 HRD-in -75.63, -56.77 92.51, -29.31 out-out-none SNCoon out-none ActLoopNT-out 6.493 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.77 APE8-rot-na 14.74 APE67-dihe-in -66.54, -21.29 -71.46, -21.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 A 454 433 13 0 0 13 [[262, 513]] 1.0 2c0i TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0OA P08631 81 526 526.0 L2G:61506 Type1.5_Front Inactive DFGin 6.623 17.558 BLBtrans DFGAsp-rot-out -102.76, 170.81 68.33, 6.06 279.79, -6.51 -62.19, 117.6 178.08, 53.25 105.15, -37.25 out-out out 13.425 Saltbr-out 14.041 HRD-in -86.82, -49.88 88.79, -24.67 out-out-none SNCoon out-none ActLoopNT-out 6.543 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.2 APE8-rot-na 27.76 APE67-dihe-in -65.03, -25.33 -76.85, -18.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 A 454 433 13 0 0 13 [[262, 513]] 1.0 2c0o TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TA P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.584 17.846 BLBtrans DFGAsp-rot-out -103.62, 161.87 63.4, 18.68 289.46, -18.94 -68.73, 122.03 173.01, 50.25 109.42, -49.86 out-out out 13.293 Saltbr-out 13.453 HRD-in -82.0, -51.15 69.41, -3.28 out-out-none SNCoon out-none ActLoopNT-out 6.066 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.05 APE8-rot-na 27.06 APE67-dihe-in -75.03, -15.66 -73.32, -16.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 A 454 427 13 0 0 13 [[262, 513]] 1.0 2c0t TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TB P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.709 17.866 BLBtrans DFGAsp-rot-out -104.05, 163.35 58.02, 34.32 293.3, -8.27 -79.78, 115.19 166.03, 51.93 89.06, 7.58 out-out out 14.206 Saltbr-out 14.127 HRD-in -92.96, -48.52 72.3, -13.86 out-out-none SNCoon out-none ActLoopNT-out 7.074 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 168.21 APE8-rot-na 23.75 APE67-dihe-in -65.46, -15.21 -125.7, -33.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 B 454 429 13 0 0 13 [[262, 513]] 1.0 2c0t TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZA P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.653 17.605 BLBtrans DFGAsp-rot-out -107.49, 162.36 65.41, 22.25 268.54, -33.15 -66.55, 118.82 172.12, 49.89 104.47, -23.12 out-out out 13.704 Saltbr-out 14.161 HRD-in -91.87, -51.27 85.65, -25.59 out-out-none SNCoon out-none ActLoopNT-out 6.947 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 29.34 APE67-dihe-in -64.65, 2.38 -52.77, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 A 454 429 13 0 0 13 [[262, 513]] 1.0 3vrz TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZB P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.496 17.504 BLBtrans DFGAsp-rot-out -106.94, 168.11 63.9, 13.84 252.07, 14.02 -60.21, 119.93 180.64, 41.8 108.28, -25.57 out-out out 13.229 Saltbr-out 13.467 HRD-in -97.14, -43.33 79.11, -20.29 out-out-none SNCoon out-none ActLoopNT-out 6.263 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.9 APE8-dihe-in -90.85, 64.85 APE8-rot-na 34.91 APE67-dihe-in -66.47, -19.82 -63.44, -23.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.492 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 B 454 430 12 0 0 12 [[262, 513]] 1.0 3vrz TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 3F5PA P08069 981 1286 1367.0 741:60001 Type1.5_Front Inactive DFGin 6.61 16.748 ABAminus DFGAsp-rot-in -138.06, -25.59 -129.58, 107.73 181.38, -16.46 -116.06, 43.16 310.54, 93.03 -78.83, -11.08 out-out out 11.275 Saltbr-out 6.906 HRD-in -67.38, -43.83 73.05, -28.09 out-in-out SNCoio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.2, 9.43 APE9-dihe-in -62.84, 138.01 APE8-dihe-in -63.08, 132.26 APE8-rot-na 338.19 APE67-dihe-in -72.6, -14.18 -69.93, -24.15 APE12-dist-na 13.896 APE11-dist-na 10.264 APE10-dist-na 9.82 APE9-dist-na 6.264 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 A 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PB P08069 981 1286 1367.0 741:60002 Type1.5_Front Inactive DFGin 6.74 16.774 ABAminus DFGAsp-rot-in -147.75, -6.76 -126.37, 106.72 190.37, -15.78 -113.94, 18.15 303.38, 100.96 -63.88, -6.59 out-out out 11.005 Saltbr-out 7.016 HRD-in -75.04, -39.09 66.41, -28.14 out-in-out SNCoio in-out ActLoopNT-in 2.98 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.44, 30.24 APE9-dihe-in -71.55, 137.53 APE8-dihe-in -59.54, 131.44 APE8-rot-na 338.8 APE67-dihe-in -62.32, -22.71 -80.06, -23.54 APE12-dist-na 13.869 APE11-dist-na 10.125 APE10-dist-na 10.151 APE9-dist-na 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 B 308 300 6 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PC P08069 981 1286 1367.0 741:60003 Type1.5_Front Inactive DFGin 6.476 16.508 ABAminus DFGAsp-rot-in -131.28, -29.71 -123.17, 122.2 184.37, -8.23 -124.32, 31.59 310.58, 97.96 -71.28, -4.47 out-out out 11.326 Saltbr-out 7.151 HRD-in -67.89, -44.01 69.59, -29.8 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -113.67, 21.52 APE9-dihe-in -66.68, 135.08 APE8-dihe-in -55.37, 125.9 APE8-rot-na 335.16 APE67-dihe-in -63.64, -20.63 -71.03, -23.62 APE12-dist-na 13.947 APE11-dist-na 10.314 APE10-dist-na 10.017 APE9-dist-na 6.347 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 C 308 303 3 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PD P08069 981 1286 1367.0 741:60004 Type1.5_Front Inactive DFGin 6.691 16.948 ABAminus DFGAsp-rot-in -123.55, -41.41 -120.41, 118.96 171.46, -26.66 -120.72, 27.37 304.28, 99.29 -67.93, -13.37 out-out out 11.466 Saltbr-out 7.444 HRD-in -72.44, -43.38 70.69, -28.87 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.64, 11.87 APE9-dihe-in -60.75, 136.9 APE8-dihe-in -61.78, 130.42 APE8-rot-na 20.36 APE67-dihe-in -67.44, -13.84 -72.23, -24.66 APE12-dist-na 13.872 APE11-dist-na 10.33 APE10-dist-na 10.049 APE9-dist-na 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 D 308 299 7 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PE P08069 981 1285 1367.0 741:60005 Type1.5_Front Inactive DFGin 6.694 16.82 ABAminus DFGAsp-rot-in -135.52, -29.09 -118.77, 122.15 185.37, -4.42 -123.6, 9.7 296.44, 108.3 -57.57, -18.08 out-out out 11.069 Saltbr-out 7.271 HRD-in -68.6, -42.13 69.21, -24.51 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -119.4, 7.14 APE9-dihe-in -54.67, 137.93 APE8-dihe-in -65.35, 131.07 APE8-rot-na 341.16 APE67-dihe-in -64.5, -10.68 -68.92, -32.58 APE12-dist-na 14.021 APE11-dist-na 10.452 APE10-dist-na 10.148 APE9-dist-na 6.28 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 E 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PF P08069 981 1285 1367.0 741:60006 Type1.5_Front Inactive DFGin 6.483 16.672 ABAminus DFGAsp-rot-in -133.64, -29.08 -124.95, 116.76 179.94, -13.2 -119.73, 22.12 307.37, 101.54 -62.11, -21.12 out-out out 11.456 Saltbr-out 7.439 HRD-in -66.51, -41.75 69.88, -16.79 out-in-out SNCoio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.91, 14.58 APE9-dihe-in -64.37, 136.64 APE8-dihe-in -51.49, 126.07 APE8-rot-na 332.53 APE67-dihe-in -71.57, -11.29 -75.66, -21.34 APE12-dist-na 14.067 APE11-dist-na 10.393 APE10-dist-na 10.014 APE9-dist-na 6.14 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 F 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PG P08069 981 1285 1367.0 741:60007 Type1.5_Front Inactive DFGin 6.83 16.816 ABAminus DFGAsp-rot-in -142.79, -22.58 -124.37, 117.71 176.98, -11.22 -119.99, 31.05 299.76, 104.87 -73.83, -11.77 out-out out 11.313 Saltbr-out 7.0 HRD-in -78.88, -44.79 72.24, -24.62 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.94, 24.79 APE9-dihe-in -73.02, 139.57 APE8-dihe-in -63.97, 132.91 APE8-rot-na 337.39 APE67-dihe-in -71.97, -5.77 -75.29, -20.42 APE12-dist-na 14.012 APE11-dist-na 10.239 APE10-dist-na 9.892 APE9-dist-na 6.221 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 G 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PH P08069 981 1286 1367.0 741:60008 Type1.5_Front Inactive DFGin 6.629 16.429 ABAminus DFGAsp-rot-in -135.18, -37.61 -123.09, 112.94 185.48, -1.81 -114.78, 16.78 310.03, 93.21 -57.54, -9.93 out-out out 11.26 Saltbr-out 7.542 HRD-in -79.51, -41.44 75.33, -29.75 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -108.47, 10.93 APE9-dihe-in -59.95, 134.42 APE8-dihe-in -57.02, 119.96 APE8-rot-na 332.96 APE67-dihe-in -72.4, -8.79 -61.06, -25.16 APE12-dist-na 14.198 APE11-dist-na 10.466 APE10-dist-na 10.185 APE9-dist-na 6.401 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 H 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PI P08069 981 1285 1367.0 741:60009 Type1.5_Front Inactive DFGin 6.637 16.461 ABAminus DFGAsp-rot-in -144.33, -12.52 -125.22, 113.79 188.79, -23.37 -116.99, 15.78 300.54, 108.07 -62.21, -14.24 out-out out 10.889 Saltbr-out 6.889 HRD-in -60.61, -42.68 67.93, -23.46 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.73, 15.28 APE9-dihe-in -67.33, 139.53 APE8-dihe-in -63.65, 128.86 APE8-rot-na 345.01 APE67-dihe-in -68.57, -17.49 -69.06, -21.27 APE12-dist-na 13.914 APE11-dist-na 10.23 APE10-dist-na 9.797 APE9-dist-na 6.228 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 I 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PJ P08069 981 1285 1367.0 741:60010 Type1.5_Front Inactive DFGin 6.647 16.713 ABAminus DFGAsp-rot-in -137.35, -22.07 -131.76, 119.09 176.99, -10.12 -115.56, 22.57 300.22, 101.26 -61.94, -18.78 out-out out 10.94 Saltbr-out 6.672 HRD-in -74.88, -41.95 72.95, -30.32 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.55, 26.2 APE9-dihe-in -76.04, 131.14 APE8-dihe-in -47.14, 118.18 APE8-rot-na 11.41 APE67-dihe-in -74.24, -9.54 -60.76, -20.49 APE12-dist-na 14.276 APE11-dist-na 10.237 APE10-dist-na 10.205 APE9-dist-na 6.46 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 J 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PK P08069 981 1285 1367.0 741:60011 Type1.5_Front Inactive DFGin 6.407 16.547 ABAminus DFGAsp-rot-in -137.37, -28.84 -124.99, 120.18 174.44, 4.56 -119.7, 16.02 301.42, 102.62 -59.26, -20.51 out-out out 11.163 Saltbr-out 6.697 HRD-in -69.13, -50.03 76.13, -25.52 out-in-out SNCoio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -116.66, 8.96 APE9-dihe-in -58.52, 142.15 APE8-dihe-in -59.15, 129.43 APE8-rot-na 338.61 APE67-dihe-in -60.69, -25.24 -69.7, -27.83 APE12-dist-na 14.114 APE11-dist-na 10.152 APE10-dist-na 9.947 APE9-dist-na 6.405 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 K 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PL P08069 981 1285 1367.0 741:60013 Type1.5_Front Inactive DFGin 6.56 16.394 ABAminus DFGAsp-rot-in -130.09, -30.53 -132.5, 115.28 164.26, 2.13 -114.91, 24.81 310.05, 96.63 -62.07, -19.46 out-out out 11.029 Saltbr-out 6.97 HRD-in -66.51, -50.25 76.73, -28.84 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -112.68, 19.75 APE9-dihe-in -67.29, 128.45 APE8-dihe-in -49.93, 126.32 APE8-rot-na 13.1 APE67-dihe-in -68.28, -21.28 -70.5, -21.67 APE12-dist-na 14.19 APE11-dist-na 10.315 APE10-dist-na 10.171 APE9-dist-na 6.356 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 L 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PM P08069 981 1285 1367.0 741:60012 Type1.5_Front Inactive DFGin 6.771 16.613 ABAminus DFGAsp-rot-in -128.57, -42.47 -122.66, 116.51 178.99, -22.16 -120.09, 38.47 314.34, 94.44 -73.17, -23.07 out-out out 11.214 Saltbr-out 7.332 HRD-in -78.25, -49.69 75.71, -26.22 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -117.51, 9.39 APE9-dihe-in -60.52, 138.49 APE8-dihe-in -61.63, 125.4 APE8-rot-na 341.15 APE67-dihe-in -68.1, -5.47 -67.37, -25.72 APE12-dist-na 13.872 APE11-dist-na 10.161 APE10-dist-na 9.914 APE9-dist-na 6.394 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 M 308 297 8 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PR P08069 981 1285 1367.0 741:60014 Type1.5_Front Inactive DFGin 6.538 16.629 ABAminus DFGAsp-rot-in -139.04, -20.87 -125.55, 103.39 185.52, 0.6 -109.5, 25.04 311.13, 96.42 -58.59, -20.19 out-out out 11.106 Saltbr-out 7.253 HRD-in -61.08, -46.93 71.37, -30.05 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -121.06, 13.96 APE9-dihe-in -63.18, 134.5 APE8-dihe-in -57.6, 125.54 APE8-rot-na 338.75 APE67-dihe-in -68.47, -18.65 -66.66, -22.95 APE12-dist-na 14.134 APE11-dist-na 10.186 APE10-dist-na 10.002 APE9-dist-na 6.439 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 R 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PS P08069 981 1286 1367.0 741:60015 Type1.5_Front Inactive DFGin 6.621 16.362 ABAminus DFGAsp-rot-in -137.74, -25.34 -122.78, 115.95 189.34, 4.69 -115.05, 8.88 304.38, 111.51 -47.71, -27.84 out-out out 11.103 Saltbr-out 6.886 HRD-in -69.09, -43.99 64.64, -15.6 out-in-out SNCoio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -120.58, 17.02 APE9-dihe-in -62.27, 136.85 APE8-dihe-in -61.63, 122.69 APE8-rot-na 21.86 APE67-dihe-in -66.47, -21.61 -67.46, -19.45 APE12-dist-na 13.986 APE11-dist-na 10.237 APE10-dist-na 10.157 APE9-dist-na 6.245 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 S 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PT P08069 981 1286 1367.0 741:60016 Type1.5_Front Inactive DFGin 6.52 16.375 ABAminus DFGAsp-rot-in -141.26, -19.49 -137.77, 101.2 180.1, -14.6 -103.13, 11.95 304.34, 96.76 -50.98, -21.44 out-out out 10.787 Saltbr-out 6.707 HRD-in -77.18, -39.29 69.12, -25.78 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.42, 13.71 APE9-dihe-in -68.71, 130.72 APE8-dihe-in -54.94, 124.12 APE8-rot-na 340.88 APE67-dihe-in -66.19, -17.17 -61.43, -26.74 APE12-dist-na 13.846 APE11-dist-na 10.239 APE10-dist-na 9.88 APE9-dist-na 6.273 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 T 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A P08069 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.753 12.09 None DFGAsp-rot-in -113.77, -141.33 -41.63, 115.12 193.94, 11.59 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.035 Saltbr-out 11.282 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.257 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.646 APE11-dist-na 8.596 APE10-dist-na 6.456 APE9-dist-na 7.111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301 289 11 0 0 0 [[999, 1268]] 1.0 3d94 TYR_IGF1R_HUMAN TYR 3.3e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA P08069 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.183 12.51 None DFGAsp-rot-in -115.76, -140.08 -56.69, 128.49 194.85, -1.13 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.581 Saltbr-out 8.136 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.922 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.172 APE9-dist-na 7.073 None None None XRAY 3.06 0.193 0.235 AAA 321 288 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB P08069 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.22 12.447 None DFGAsp-rot-in -115.29, -140.05 -57.59, 130.35 191.36, 3.91 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.581 Saltbr-out 8.138 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.993 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.11 APE9-dist-na 7.068 None None None XRAY 3.06 0.193 0.235 BBB 321 287 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.166 12.505 None DFGAsp-rot-in -114.85, -140.89 -57.29, 129.65 193.0, 0.84 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.547 Saltbr-out 8.078 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.653 APE10-dist-na 6.184 APE9-dist-na 7.131 None None None XRAY 3.06 0.193 0.235 CCC 321 286 13 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.219 12.459 None DFGAsp-rot-in -115.04, -139.19 -57.22, 129.11 193.91, 0.08 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.605 Saltbr-out 8.095 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.935 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.553 APE10-dist-na 5.986 APE9-dist-na 7.125 None None None XRAY 3.06 0.193 0.235 DDD 321 287 12 0 0 4 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.27 12.44 None DFGAsp-rot-in -115.61, -138.87 -56.86, 128.87 193.98, 0.75 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.516 Saltbr-out 8.092 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.951 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.155 APE9-dist-na 7.113 None None None XRAY 3.06 0.193 0.235 EEE 321 285 14 0 0 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.31 12.506 None DFGAsp-rot-in -114.84, -139.12 -57.32, 129.09 194.57, -0.49 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.562 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.267 APE11-dist-na 9.704 APE10-dist-na 6.176 APE9-dist-na 7.071 None None None XRAY 3.06 0.193 0.235 FFF 321 287 12 0 0 3 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.215 12.411 None DFGAsp-rot-in -115.39, -138.9 -56.85, 128.81 194.12, 1.71 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.582 Saltbr-out 8.151 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.313 APE9-dist-na 6.925 None None None XRAY 3.06 0.193 0.235 GGG 321 284 15 0 0 6 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.201 12.494 None DFGAsp-rot-in -116.04, -140.1 -57.52, 129.83 192.69, 1.38 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.616 Saltbr-out 8.121 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.154 APE9-dist-na 7.165 None None None XRAY 3.06 0.193 0.235 HHH 321 285 14 0 0 5 [[999, 1268]] 1.0 8pyi TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.523 11.883 None DFGAsp-rot-in -122.71, -134.04 -48.48, 117.08 193.21, -3.88 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.105 Saltbr-out 7.07 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.78 APE11-dist-na 9.341 APE10-dist-na 6.003 APE9-dist-na 7.412 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.668 11.698 None DFGAsp-rot-in -120.23, -145.7 -34.99, 114.07 201.91, -7.17 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.23 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.71 APE11-dist-na 9.436 APE10-dist-na 6.009 APE9-dist-na 7.413 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.504 11.893 None DFGAsp-rot-in -117.5, -144.25 -35.28, 118.67 193.73, 0.69 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.205 Saltbr-out 6.568 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.032 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-na 7.275 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.586 11.812 None DFGAsp-rot-in -120.23, -138.34 -41.88, 115.18 198.43, -7.81 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.156 Saltbr-out 7.057 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.098 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.179 APE11-dist-na 9.253 APE10-dist-na 6.021 APE9-dist-na 7.453 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304 304 0 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.534 11.884 None DFGAsp-rot-in -122.97, -133.9 -50.03, 120.11 190.59, -4.54 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.09 Saltbr-out 7.001 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.756 APE11-dist-na 9.32 APE10-dist-na 6.009 APE9-dist-na 7.417 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.669 11.686 None DFGAsp-rot-in -119.91, -143.87 -36.57, 117.22 200.05, -12.35 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.245 Saltbr-out 7.495 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.696 APE11-dist-na 9.431 APE10-dist-na 6.025 APE9-dist-na 7.415 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.495 11.888 None DFGAsp-rot-in -115.22, -143.92 -37.17, 121.14 194.75, -1.88 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.212 Saltbr-out 6.568 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.018 APE11-dist-na 9.418 APE10-dist-na 6.068 APE9-dist-na 7.312 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH P08069 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.564 11.84 None DFGAsp-rot-in -117.51, -139.77 -40.96, 115.52 196.3, -3.46 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.132 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.113 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.184 APE11-dist-na 9.261 APE10-dist-na 6.031 APE9-dist-na 7.449 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304 303 0 0 0 0 [[999, 1268]] 1.0 5hzn TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.547 15.218 None DFGAsp-rot-in -93.96, -126.86 -75.33, 119.05 185.67, 17.74 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.644 Saltbr-out 6.203 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.71 APE11-dist-na 10.945 APE10-dist-na 9.756 APE9-dist-na 7.506 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307 306 0 0 0 0 [[1023, 1292]] 1.0 5hhw TYR_INSR_HUMAN TYR 5.7e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 6PDJA P06239 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.351 8.956 BBAminus DFGAsp-rot-in -108.06, 146.7 -118.62, 138.04 175.49, 43.58 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.115 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.007 APE11-dist-na 10.591 APE10-dist-na 12.887 APE9-dist-na 6.856 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288 271 0 0 0 0 [[245, 496]] 1.0 6pdj TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 7AAZA Q12866 574 863 999.0 R6K:901 Type1.5_Front Inactive DFGin 6.931 13.0 BLAminus DFGAsp-rot-in -138.31, -157.88 39.97, 76.8 204.07, -16.71 -86.63, 13.92 303.38, 139.91 -55.98, -23.43 out-out out 13.714 Saltbr-out 13.412 HRD-in -73.08, -57.78 72.91, 6.58 out-in-out SNCoio in-out ActLoopNT-in 2.755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -69.02, -26.36 APE9-dihe-in -66.36, 123.32 APE8-dihe-in -78.41, 127.1 APE8-rot-na 30.52 APE67-dihe-in -75.24, 0.32 -53.59, -39.62 APE12-dist-na 9.191 APE11-dist-na 11.609 APE10-dist-na 7.365 APE9-dist-na 4.907 None None None XRAY 1.855 0.189 0.219 A 296 290 0 0 0 0 [[587, 856]] 1.0 7aaz TYR_MERTK_HUMAN TYR 1.2e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus DFGAsp-rot-in -138.66, -158.87 44.96, 74.5 205.27, 0.86 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-na 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHJA Q12866 578 862 999.0 A1APG:60901 Type1.5_Front Inactive DFGin 7.068 13.244 BLAminus DFGAsp-rot-out -146.72, -174.1 64.74, 69.57 296.14, 87.8 -92.99, 18.47 306.82, 135.89 -58.57, -33.38 out-out out 13.147 Saltbr-out 13.083 HRD-in -74.38, -50.97 66.43, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -101.13, 12.6 APE9-dihe-in -72.99, 145.36 APE8-dihe-in -59.15, 119.95 APE8-rot-na 335.8 APE67-dihe-in -75.1, -1.94 -63.08, -26.94 APE12-dist-na 7.006 APE11-dist-na 11.862 APE10-dist-na 11.009 APE9-dist-na 6.692 None None None XRAY 2.294 0.22 0.252 A 323 279 6 0 0 0 [[587, 856]] 1.0 9bhj TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHKA Q12866 578 862 999.0 A1APH:60901 Type1.5_Front Inactive DFGin 7.438 13.112 BLAminus DFGAsp-rot-out -146.17, -169.74 58.59, 57.61 300.0, 89.03 -88.08, 14.92 314.86, 133.55 -56.57, -30.36 out-out out 13.408 Saltbr-out 13.148 HRD-in -71.96, -51.79 69.44, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -99.49, 5.66 APE9-dihe-in -63.51, 142.65 APE8-dihe-in -57.87, 119.03 APE8-rot-na 336.99 APE67-dihe-in -73.75, -3.45 -57.71, -31.48 APE12-dist-na 7.129 APE11-dist-na 11.95 APE10-dist-na 11.013 APE9-dist-na 6.435 None None None XRAY 2.106 0.208 0.229 A 323 273 12 0 0 0 [[587, 856]] 1.0 9bhk TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW2A Q12866 571 862 999.0 S4W:60901 Type1.5_Front Inactive DFGin 6.721 12.964 BLBminus DFGAsp-rot-in -150.9, -171.53 41.59, 54.7 237.99, -37.37 -57.18, 136.95 317.76, 109.5 -43.48, 130.9 out-out out 12.917 Saltbr-out 13.1 HRD-in -73.03, -51.56 71.01, 1.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.98 APE8-rot-na 17.36 APE67-dihe-in -72.89, 2.66 -33.8, -45.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 2.1 0.208 0.238 A 298 267 25 0 0 18 [[587, 856]] 1.0 7aw2 TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLSA Q12866 571 862 999.0 VJZ:60901 Type1.5_Front Inactive DFGin 6.656 13.567 BLBminus DFGAsp-rot-out -153.83, -175.53 51.86, 59.49 254.96, -38.28 -72.66, 142.42 308.34, 110.17 -75.07, 999.0 out-out out 13.556 Saltbr-out 13.877 HRD-in -70.87, -52.35 83.16, -32.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.15 APE8-rot-na 35.66 APE67-dihe-in -76.51, -1.1 -58.07, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 1.89 0.222 0.282 A 298 269 23 0 0 19 [[587, 856]] 1.0 7ols TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLVA Q12866 571 862 999.0 VK2:60901 Type1.5_Front Inactive DFGin 6.528 13.64 BLBminus DFGAsp-rot-out -149.58, -174.75 55.04, 54.02 255.64, -42.84 -65.24, 140.11 308.45, 116.95 -72.6, 999.0 out-out out 13.503 Saltbr-out 14.112 HRD-in -71.43, -46.21 70.23, 5.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.84 APE8-rot-na 31.04 APE67-dihe-in -72.99, -5.09 -55.61, -36.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 2.13 0.21 0.247 A 298 269 23 0 0 19 [[587, 856]] 1.0 7olv TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLXA Q12866 571 862 999.0 VK5:60901 Type1.5_Front Inactive DFGin 6.209 13.727 BLBminus DFGAsp-rot-in -149.38, -179.13 56.05, 51.35 227.01, -28.44 -58.87, 139.21 312.09, 118.2 -79.48, 999.0 out-out out 13.764 Saltbr-out 12.352 HRD-in -72.38, -52.17 78.72, -5.83 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 42.77 APE8-rot-na 35.47 APE67-dihe-in -74.39, -3.51 -55.36, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.205 0.251 A 298 271 21 0 0 19 [[587, 856]] 1.0 7olx TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVXA Q12866 577 862 999.0 S4K:901 Type1.5_Front Inactive DFGin 6.212 14.187 BLBplus DFGAsp-rot-out -139.94, 176.96 57.63, 33.7 284.36, -23.5 -91.93, 149.58 50.89, 81.01 -76.42, 165.87 out-out out 12.696 Saltbr-out 9.191 HRD-in -70.33, -65.18 70.62, 12.45 out-out-out SNCooo out-out ActLoopNT-out 5.197 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -81.78, -23.56 APE9-dihe-in -75.41, 164.94 APE8-dihe-in -70.62, 164.17 APE8-rot-na 350.35 APE67-dihe-in -69.09, -9.08 -44.67, -43.43 APE12-dist-na 13.398 APE11-dist-na 14.161 APE10-dist-na 11.783 APE9-dist-na 4.623 None None None XRAY 2.44 0.216 0.259 A 313 276 10 0 0 5 [[587, 856]] 1.0 7avx TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZA Q12866 577 864 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 16.995 9.166 None DFGAsp-rot-in -144.96, 178.8 -147.12, 97.05 189.15, 3.97 -55.74, 999.0 272.88, 54.11 999.0, 999.0 out-none out 12.645 Saltbr-none 999.0 HRD-in -83.04, -57.33 76.85, -1.67 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.11 APE8-rot-na 9.43 APE67-dihe-in -73.23, -7.29 -55.21, -31.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.6 0.224 0.267 A 294 263 25 0 0 20 [[587, 856]] 1.0 9krz TYR_MERTK_HUMAN TYR 1.2e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZB Q12866 575 863 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 17.116 9.26 None DFGAsp-rot-in -136.76, -173.26 -147.11, 97.01 225.55, -15.88 -63.71, 999.0 262.09, 109.75 999.0, 999.0 out-none out 12.404 Saltbr-none 999.0 HRD-in -59.48, -61.4 74.72, -1.69 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.37 APE8-rot-na 32.13 APE67-dihe-in -79.29, -5.37 -59.11, -19.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.6 0.224 0.267 B 294 260 29 0 0 20 [[587, 856]] 1.0 9krz TYR_MERTK_HUMAN TYR 1.2e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3U6HA P08581 1051 1351 1390.0 03X:1 Type1.5_Front Inactive DFGin 5.5 14.419 BLBplus DFGAsp-rot-out -145.15, 179.51 61.38, 23.56 257.09, 20.81 -82.38, 149.62 53.62, 89.86 90.75, 999.0 out-out out 12.113 Saltbr-out 7.679 HRD-in -72.28, -53.74 82.85, -16.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 50.02 APE8-rot-na 30.69 APE67-dihe-in -72.37, 0.17 -64.56, -34.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.0 0.221 0.274 A 309 280 21 0 0 21 [[1078, 1339]] 1.0 3u6h TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3U6IA P08581 1051 1351 1390.0 044:1 Type1.5_Front Inactive DFGin 5.277 14.587 BLBplus DFGAsp-rot-out -134.83, 174.49 60.14, 23.77 274.48, -6.43 -73.51, 140.85 47.46, 91.22 78.44, 999.0 out-out out 12.048 Saltbr-out 8.482 HRD-in -67.0, -53.9 81.23, -23.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.68 APE8-dihe-in -90.4, 68.47 APE8-rot-na 28.01 APE67-dihe-in -76.04, -5.5 -62.36, -28.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.691 None None None XRAY 2.1 0.208 0.257 A 309 281 20 0 0 20 [[1078, 1339]] 1.0 3u6i TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKA P08581 1054 1351 1390.0 MT4:1 Type1.5_Front Inactive DFGin 5.064 14.093 None DFGAsp-rot-in -134.75, -178.01 61.2, 27.83 218.56, 7.55 -81.51, 999.0 42.72, 82.19 999.0, 999.0 out-out out 12.813 Saltbr-out 7.941 HRD-in -70.71, -51.36 83.62, -19.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 26.89 APE8-rot-na 29.1 APE67-dihe-in -75.12, -5.25 -59.44, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.2 0.257 0.292 A 310 276 22 0 0 22 [[1078, 1339]] 1.0 3efk TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB P08581 1054 1351 1390.0 MT4:2 Type1.5_Front Inactive DFGin 5.171 14.171 None DFGAsp-rot-in -136.11, -178.89 60.83, 31.64 221.42, 18.82 -88.75, 999.0 42.99, 77.64 999.0, 999.0 out-out out 12.549 Saltbr-out 7.623 HRD-in -66.0, -59.6 86.12, -12.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.71 APE8-rot-na 33.98 APE67-dihe-in -75.58, -3.26 -55.05, -32.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.2 0.257 0.292 B 310 272 26 0 0 22 [[1078, 1339]] 1.0 3efk TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8ANSA P08581 1052 1346 1390.0 MDI:1402 Type1.5_Front Inactive DFGout 21.988 12.134 BBAminus DFGAsp-rot-in -113.69, 156.55 -126.28, 136.74 176.58, 50.56 -116.06, 28.6 291.38, 93.7 114.66, -11.19 out-none out 16.715 Saltbr-none 999.0 HRD-in -66.61, -50.14 72.94, -14.68 none-in-none SNCnin in-none ActLoopNT-in 2.814 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.39 APE8-dihe-in -71.16, 118.3 APE8-rot-na 25.27 APE67-dihe-in -73.48, 1.82 -58.2, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.972 D1228V None None XRAY 2.01 0.232 0.277 A 296 277 18 0 0 15 [[1078, 1339]] 1.0 8ans TYR_MET_HUMAN TYR 1.3e-91 312.5 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1A P08581 1053 1346 1390.0 A1AB1:1401 Type1.5_Front Inactive DFGout 14.819 9.436 BBAminus DFGAsp-rot-in -108.11, 147.26 -117.32, 132.26 185.46, 9.39 -96.14, -16.7 282.99, 100.28 74.09, 31.57 out-out out 14.533 Saltbr-out 11.844 HRD-in -73.59, -41.12 80.85, -53.9 out-out-in SNCooi out-in ActLoopNT-out 8.453 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -73.38, 142.57 APE9-dihe-in -84.31, 136.88 APE8-dihe-in -79.64, 70.29 APE8-rot-na 34.05 APE67-dihe-in -83.39, -14.09 -70.01, -29.83 APE12-dist-na 999.0 APE11-dist-na 9.426 APE10-dist-na 10.403 APE9-dist-na 8.627 None None None XRAY 3.11 0.253 0.298 A 309 284 10 0 0 7 [[1078, 1339]] 1.0 8vi1 TYR_MET_HUMAN TYR 1.1e-91 313.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1B P08581 1050 1345 1390.0 A1AB1:1401 Type1.5_Front Inactive DFGout 15.272 8.725 BBAminus DFGAsp-rot-in -108.54, 151.43 -123.32, 136.74 187.88, 14.93 -110.22, 12.52 275.64, 111.62 71.37, 50.45 out-out out 15.162 Saltbr-out 11.973 HRD-in -74.07, -53.17 75.69, 9.37 out-out-in SNCooi out-in ActLoopNT-out 7.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.88, 110.5 APE9-dihe-in -114.0, 153.27 APE8-dihe-in -80.31, 90.69 APE8-rot-na 32.48 APE67-dihe-in -77.51, -25.6 -72.23, -29.3 APE12-dist-na 999.0 APE11-dist-na 9.908 APE10-dist-na 10.171 APE9-dist-na 7.148 None None None XRAY 3.11 0.253 0.298 B 309 287 9 0 0 9 [[1078, 1339]] 1.0 8vi1 TYR_MET_HUMAN TYR 1.1e-91 313.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8A P08581 1073 1345 1390.0 MDI:1405 Type1.5_Front Inactive DFGout 21.707 13.171 BBAminus DFGAsp-rot-in -94.14, 151.51 -120.93, 127.96 170.89, 55.41 -109.22, 32.25 303.58, 88.2 110.31, 1.2 out-out out 16.43 Saltbr-out 20.272 HRD-in -54.67, -51.39 71.04, -1.89 out-in-none SNCoin in-none ActLoopNT-in 2.9 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.15 APE8-rot-na 3.41 APE67-dihe-in -68.88, -23.67 -46.98, -37.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.394 0.244 0.298 A 296 244 29 0 0 10 [[1078, 1339]] 1.0 8an8 TYR_MET_HUMAN TYR 6.1e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8B P08581 1058 1345 1390.0 MDI:1402 Type1.5_Front Inactive DFGout 21.849 13.195 BBAminus DFGAsp-rot-in -106.1, 150.5 -120.05, 128.27 166.7, 51.19 -113.48, 46.76 300.29, 99.64 94.11, -3.01 out-out out 16.643 Saltbr-out 17.83 HRD-in -61.73, -46.11 67.66, -9.48 out-in-none SNCoin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 100.6 APE8-dihe-in -76.12, 118.46 APE8-rot-na 29.89 APE67-dihe-in -71.35, -4.52 -60.81, -23.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.046 None None None XRAY 2.394 0.244 0.298 B 296 263 25 0 0 9 [[1078, 1339]] 1.0 8an8 TYR_MET_HUMAN TYR 6.1e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJA P08581 1054 1351 1390.0 MT3:1 Type1.5_Front Inactive DFGout 14.778 8.785 None DFGAsp-rot-in -121.25, 162.39 -104.89, -29.61 213.31, -61.02 54.56, 999.0 265.44, 110.5 999.0, 999.0 out-out out 13.253 Saltbr-out 9.71 HRD-in -61.96, -46.17 77.81, -13.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.71 APE8-rot-na 30.83 APE67-dihe-in -80.48, 4.82 -65.53, -29.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.6 0.247 0.288 A 310 276 22 0 0 22 [[1078, 1339]] 1.0 3efj TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 5T3QA P08581 1050 1350 1390.0 75H:61401 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -142.6, 175.57 45.45, 999.0 279.25, -5.86 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.187 Saltbr-out 9.495 HRD-in -69.85, -55.7 82.52, -23.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 169.98 APE8-dihe-in -92.78, 65.48 APE8-rot-na 37.33 APE67-dihe-in -70.53, -2.22 -62.22, -34.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.582 None None None XRAY 2.0 0.198 0.248 A 309 277 24 0 0 22 [[1078, 1339]] 1.0 5t3q TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNA P08581 1057 1351 1390.0 AM7:1 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -145.52, 173.92 -137.55, 999.0 29.69, -41.77 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.313 Saltbr-out 10.101 HRD-in -80.8, -43.71 73.65, -29.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 31.17 APE8-rot-na 23.12 APE67-dihe-in -68.97, -9.97 -50.29, -35.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.241 0.294 A 310 268 27 0 0 23 [[1078, 1339]] 1.0 2rfn TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNB P08581 1056 1351 1390.0 AM7:1 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -149.27, 171.85 -132.94, 999.0 345.81, 32.63 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.46 Saltbr-out 10.805 HRD-in -77.04, -45.81 74.29, -30.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 33.53 APE8-rot-na 35.74 APE67-dihe-in -65.01, -12.86 -49.25, -36.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.241 0.294 B 310 269 27 0 0 23 [[1078, 1339]] 1.0 2rfn TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJB P08581 1054 1351 1390.0 MT3:2 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-in -130.74, -175.38 -145.16, 999.0 212.24, -25.22 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.373 Saltbr-none 999.0 HRD-in -71.19, -53.04 82.76, -19.12 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -10.37 APE8-rot-na 31.62 APE67-dihe-in -71.17, -12.51 -66.7, -29.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.6 0.247 0.288 B 310 275 23 0 0 23 [[1078, 1339]] 1.0 3efj TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR RET RET_HUMAN 7DU8A P07949 714 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.959 14.089 BLAminus DFGAsp-rot-in -139.9, -176.36 61.28, 71.22 180.69, 23.55 -96.57, 22.61 290.51, 82.58 -62.34, -43.12 in-in in 7.246 Saltbr-in 2.725 HRD-in -70.49, -42.48 76.18, -46.1 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.78, 19.85 APE9-dihe-in -91.59, 136.68 APE8-dihe-in -57.27, 135.39 APE8-rot-na 326.69 APE67-dihe-in -68.65, -17.13 -56.96, -36.43 APE12-dist-na 13.472 APE11-dist-na 9.218 APE10-dist-na 7.3 APE9-dist-na 5.634 None None None XRAY 2.75 0.217 0.277 A 314 286 13 0 0 0 [[724, 1007]] 1.0 7du8 TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7DU8B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.866 14.457 BLAminus DFGAsp-rot-in -139.37, -177.62 63.4, 72.86 189.15, 35.21 -98.32, 23.3 293.23, 81.57 -64.12, -44.29 in-in in 7.349 Saltbr-in 3.227 HRD-in -70.76, -41.16 77.27, -46.88 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -119.72, 24.05 APE9-dihe-in -92.66, 135.69 APE8-dihe-in -57.1, 135.94 APE8-rot-na 330.01 APE67-dihe-in -67.74, -17.88 -57.22, -36.2 APE12-dist-na 12.963 APE11-dist-na 8.955 APE10-dist-na 7.341 APE9-dist-na 5.668 None None None XRAY 2.75 0.217 0.277 B 314 274 31 0 0 10 [[724, 1007]] 1.0 7du8 TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7JU6B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.853 14.558 BLAminus DFGAsp-rot-in -133.87, -179.77 59.88, 75.8 189.5, 16.1 -96.18, 17.81 292.2, 77.2 -56.92, -30.18 in-in in 7.676 Saltbr-in 2.717 HRD-in -72.4, -43.27 78.98, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.34, 21.56 APE9-dihe-in -92.4, 131.54 APE8-dihe-in -51.97, 128.7 APE8-rot-na 329.4 APE67-dihe-in -67.8, -13.47 -45.61, -41.79 APE12-dist-na 13.246 APE11-dist-na 9.219 APE10-dist-na 7.607 APE9-dist-na 5.405 None None None XRAY 2.06 0.199 0.249 B 314 286 22 0 0 9 [[724, 1007]] 1.0 7ju6 TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR SYK KSYK_HUMAN 3TUCA P43405 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.556 15.019 BLBplus DFGAsp-rot-out -114.33, 165.27 53.65, 40.82 279.53, -19.63 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.471 Saltbr-out 7.068 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.216 0.285 A 299 257 19 0 0 19 [[370, 628]] 1.0 3tuc TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

All / All / Type1.5_Front

Total number of chains: 213
Active chains: 7
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 80 37.6% 4QTBA
DFGin ABAminus 27 12.7% 4C2VA
DFGin None 27 12.7% 5HHWA
DFGin BLBminus 21 9.9% 7QGPA
DFGin BLBplus 17 8.0% 9EJSA
DFGinter None 9 4.2% 9KS5B
DFGout BBAminus 9 4.2% 6PDJA
DFGin BLBtrans 8 3.8% 5DRBA
DFGin BLAplus 5 2.3% 7YAWB
DFGout None 5 2.3% 6HJKA
None None 5 2.3% 2C6EB

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK5 GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.267 12.797 ABAminus DFGAsp-rot-in -122.04, -4.62 -137.77, 133.15 190.13, -65.06 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.484 Saltbr-in 2.781 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.951 APE10-dist-in 6.101 APE9-dist-in 3.92 None None None XRAY 2.42 0.196 0.243 A 598 499 0 0 0 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.3e-84 288.8 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PRKACA KAPCA_BOVIN 1XH9A P00517 14 351 351.0 R69:60351 Type1.5_Front Inactive DFGin 6.209 14.353 BLAminus DFGAsp-rot-out -129.75, -179.11 60.33, 73.87 284.38, -8.82 -88.04, 22.6 274.32, 67.63 -61.73, -24.72 in-in in 8.581 Saltbr-in 2.609 HRD-in -83.79, -50.21 70.28, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.47, 163.02 APE9-dihe-na 127.04, -169.55 APE8-dihe-in -104.83, 132.1 APE8-rot-in 300.02 APE67-dihe-in -61.76, -25.27 -43.65, -49.85 APE12-dist-in 8.298 APE11-dist-in 11.805 APE10-dist-in 6.219 APE9-dist-in 3.696 Q85E,V124A,L174M,Q182K,F188L TPO198,SEP339 TPO198,SEP339 XRAY 1.64 0.166 0.199 A 350 338 0 0 0 0 [[44, 298]] 1.0 1xh9 Bos taurus AGC_PRKACA_BOVIN AGC 1e-94 322.6 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SVHA P00517 15 351 351.0 I08:60351 Type1.5_Front Inactive DFGin 6.29 14.359 BLAminus DFGAsp-rot-out -115.3, -171.03 56.71, 72.97 299.69, 70.16 -89.54, 18.36 276.49, 75.83 -65.64, -21.28 in-in in 8.519 Saltbr-in 2.417 HRD-in -84.39, -53.98 69.64, 16.78 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.15, 156.51 APE9-dihe-na 127.45, -173.0 APE8-dihe-in -94.86, 131.95 APE8-rot-in 296.28 APE67-dihe-in -64.98, -17.24 -40.94, -52.95 APE12-dist-in 8.685 APE11-dist-in 11.721 APE10-dist-in 6.22 APE9-dist-in 3.712 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.214 0.259 A 350 337 0 0 0 0 [[44, 298]] 1.0 1svh Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK PLK1 Q4KMI8_DANRE 3DB6A Q4KMI8 24 310 595.0 FRS:1 Type1.5_Front Inactive DFGin 5.817 15.954 BLAminus DFGAsp-rot-in -142.4, -169.51 60.61, 84.89 174.3, 25.49 -102.5, 26.5 287.92, 83.73 -63.45, -15.75 out-out out 11.643 Saltbr-out 7.205 HRD-in -75.01, -40.51 67.41, -16.08 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.76, 87.23 APE9-dihe-na 133.88, 161.1 APE8-dihe-in -107.95, 116.2 APE8-rot-in 306.39 APE67-dihe-out -75.67, -58.88 -71.76, 164.15 APE12-dist-in 11.272 APE11-dist-out 7.484 APE10-dist-in 7.511 APE9-dist-out 8.776 T196D None None XRAY 2.85 0.225 0.257 A 301 287 0 0 0 0 [[39, 291]] 1.0 3db6 Danio rerio CAMK_PLK1_DANRE CAMK 9.2e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
TYR SRC SRC_CHICK 4DGGA P00523 256 533 533.0 I76:601 Type1.5_Front Inactive DFGin 7.182 16.052 BLBminus DFGAsp-rot-in -138.93, 160.43 60.89, 77.08 214.6, 49.5 -83.17, 130.88 289.59, 69.05 -67.2, 999.0 out-none out 12.501 Saltbr-none 999.0 HRD-in -77.19, -53.85 87.04, -25.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.96 APE8-dihe-in -89.03, 71.14 APE8-rot-na 37.27 APE67-dihe-in -65.17, -28.22 -72.82, -18.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.855 None None None XRAY 2.65 0.21 0.252 A 286 261 17 0 0 17 [[267, 518]] 1.0 4dgg Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5J5SA P00523 258 533 533.0 6G3:601 Type1.5_Front Inactive DFGin 7.473 17.115 BLBminus DFGAsp-rot-out -139.23, 176.61 47.74, 68.55 291.15, -55.75 -62.62, 139.94 285.48, 65.31 -73.07, 999.0 out-out out 12.45 Saltbr-out 11.993 HRD-in -82.63, -54.31 82.21, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.84 APE8-rot-na 34.31 APE67-dihe-in -69.03, -18.92 -52.03, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.153 0.17 0.216 A 286 258 18 0 0 18 [[267, 518]] 1.0 5j5s Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5J5SB P00523 256 533 533.0 6G3:601 Type1.5_Front Inactive DFGin 6.972 16.373 BLBminus DFGAsp-rot-out -139.39, 176.63 48.37, 68.06 289.4, -55.26 -63.65, 138.85 285.11, 65.43 -74.42, 999.0 out-out out 12.567 Saltbr-out 12.185 HRD-in -81.75, -53.76 82.55, -14.27 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.16 APE8-rot-na 34.77 APE67-dihe-in -70.17, -21.94 -51.94, -30.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.153 0.17 0.216 B 286 258 20 0 0 18 [[267, 518]] 1.0 5j5s Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFB P00523 258 533 533.0 PD5:601 Type1.5_Front Inactive DFGin 6.141 12.601 None DFGAsp-rot-in -150.33, 164.09 75.91, 111.22 240.0, -40.51 -150.95, 999.0 2.54, 56.9 999.0, 999.0 out-none out 11.115 Saltbr-none 999.0 HRD-in -102.4, -44.0 81.56, -46.14 none-in-none SNCnin in-none ActLoopNT-in 3.221 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -83.83, 51.78 APE8-rot-na 4.43 APE67-dihe-in -63.43, -19.12 -50.83, -42.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.293 L317I None None XRAY 2.75 0.194 0.232 B 286 258 18 0 0 16 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7.2e-94 319.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC AKT1 AKT1_HUMAN 3QKKA P31749 144 478 480.0 SMH:60001 Type1.5_Front Inactive DFGin 6.383 13.598 BLAminus DFGAsp-rot-out -116.54, -179.44 52.7, 85.0 291.28, -88.93 -102.02, 14.36 303.33, 93.01 -66.45, -23.02 in-in in 8.916 Saltbr-in 2.342 HRD-in -78.65, -51.68 79.72, -12.12 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.57, 164.52 APE9-dihe-na 135.56, -139.12 APE8-dihe-in -127.86, 127.7 APE8-rot-in 299.02 APE67-dihe-in -62.38, -25.83 -44.42, -46.66 APE12-dist-in 8.22 APE11-dist-in 11.566 APE10-dist-in 6.028 APE9-dist-in 3.779 S473D TPO308 TPO308 XRAY 2.3 0.202 0.25 A 341 327 0 0 0 0 [[150, 408]] 1.0 3qkk Homo sapiens AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK2 ARBK1_HUMAN 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.407 13.123 BLAminus DFGAsp-rot-in -119.49, 148.71 76.08, 97.29 197.42, -12.71 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.399 Saltbr-in 2.971 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.151 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.922 APE11-dist-in 11.89 APE10-dist-in 5.931 APE9-dist-in 3.549 None None None XRAY 2.7 0.215 0.257 A 547 414 0 0 0 0 [[191, 453]] 1.0 5uuu Homo sapiens AGC_GRK2_HUMAN AGC 3.8e-77 268.3 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKKA P25098 30 667 689.0 8DJ:702 Type1.5_Front Inactive DFGin 5.44 12.848 BLAminus DFGAsp-rot-out -148.52, 179.61 57.76, 73.54 251.91, 52.8 -87.98, 8.97 274.06, 69.08 -60.04, -18.89 in-in in 8.271 Saltbr-in 2.669 HRD-in -76.24, -37.94 75.49, -51.75 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.39, 145.94 APE9-dihe-na 143.2, -151.45 APE8-dihe-in -131.14, 141.32 APE8-rot-in 299.97 APE67-dihe-in -67.12, -33.98 -48.24, -30.82 APE12-dist-in 9.635 APE11-dist-in 11.819 APE10-dist-in 5.846 APE9-dist-in 4.157 S670A None None XRAY 2.6 0.224 0.281 A 642 613 0 0 0 0 [[191, 453]] 1.0 5ukk Homo sapiens AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 6U7CA P25098 30 669 689.0 Q1Y:701 Type1.5_Front Inactive DFGin 5.061 12.454 BLAminus DFGAsp-rot-out -136.54, 170.55 57.52, 81.77 289.0, 20.73 -86.77, 20.22 308.16, 7.53 -58.1, -34.47 in-in in 9.05 Saltbr-in 2.543 HRD-in -72.35, -46.72 70.07, -13.25 in-in-in SNCiii in-in ActLoopNT-in 3.37 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 132.95 APE9-dihe-na 147.35, -168.5 APE8-dihe-in -105.63, 128.22 APE8-rot-in 297.44 APE67-dihe-inflip 124.86, -14.55 -55.92, 113.23 APE12-dist-in 10.206 APE11-dist-in 12.016 APE10-dist-in 6.072 APE9-dist-in 3.485 None None None XRAY 2.44 0.237 0.262 A 689 631 0 0 0 0 [[191, 453]] 1.0 6u7c Homo sapiens AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCYA O15530 73 358 556.0 3Q3:371 Type1.5_Front Inactive DFGin 6.388 14.592 BLAminus DFGAsp-rot-in -136.93, -173.16 70.99, 75.14 183.59, 13.71 -110.32, 14.26 284.13, 86.28 -62.73, -28.34 in-in in 8.419 Saltbr-in 2.559 HRD-in -71.32, -53.51 82.01, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 125.83 APE9-dihe-na -76.07, -148.77 APE8-dihe-in -79.07, 127.11 APE8-rot-in 312.38 APE67-dihe-in -58.65, -24.48 -40.2, -55.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.317 APE9-dist-in 4.499 None SEP241 SEP241 XRAY 2.2 0.181 0.212 A 312 275 11 0 0 11 [[82, 342]] 1.0 3qcy Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.584 14.791 BLAminus DFGAsp-rot-in -135.89, -173.14 73.55, 73.02 182.88, 14.17 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.526 Saltbr-in 2.573 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.765 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312 274 12 0 0 12 [[82, 342]] 1.0 3qd0 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD3A O15530 71 358 556.0 3Q5:360 Type1.5_Front Inactive DFGin 6.64 14.776 BLAminus DFGAsp-rot-in -136.15, -173.35 75.08, 78.84 181.88, 8.0 -114.86, 7.79 284.21, 92.48 -60.8, -30.07 in-in in 8.47 Saltbr-in 2.547 HRD-in -69.84, -52.9 76.92, -8.58 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.87, 124.76 APE9-dihe-na -70.78, -165.19 APE8-dihe-in -61.65, 129.32 APE8-rot-in 306.27 APE67-dihe-in -62.1, -22.78 -46.86, -49.49 APE12-dist-in 8.992 APE11-dist-out 5.734 APE10-dist-out 10.414 APE9-dist-in 4.038 None SEP241 SEP241 XRAY 2.0 0.185 0.211 A 312 279 9 0 0 9 [[82, 342]] 1.0 3qd3 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.403 14.626 BLAminus DFGAsp-rot-in -137.72, -173.39 72.99, 75.84 178.14, 13.4 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.558 Saltbr-in 2.79 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.12 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312 276 12 0 0 12 [[82, 342]] 1.0 3qd4 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6C0TA Q13976 337 671 671.0 EE4:701 Type1.5_Front Inactive DFGin 5.9 14.257 BLAminus DFGAsp-rot-out -131.41, 173.3 67.52, 81.76 264.71, -7.5 -101.27, 23.85 278.07, 65.63 -65.26, -23.23 in-in in 8.935 Saltbr-in 2.797 HRD-in -100.02, -51.71 77.78, -11.77 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.5, 158.55 APE9-dihe-na 107.94, 162.3 APE8-dihe-in -69.48, 141.18 APE8-rot-out 79.81 APE67-dihe-in -72.66, -16.0 -52.58, -33.36 APE12-dist-in 7.74 APE11-dist-in 11.364 APE10-dist-in 5.987 APE9-dist-in 4.819 None TPO517 TPO517 XRAY 1.98 0.21 0.244 A 347 335 0 0 0 0 [[360, 619]] 1.0 6c0t Homo sapiens AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUA Q13464 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus DFGAsp-rot-in -144.77, -177.33 55.22, 80.15 194.27, 8.27 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUB Q13464 6 402 1354.0 65R:60501 Type1.5_Front Inactive DFGin 6.027 12.975 BLAminus DFGAsp-rot-in -150.94, 172.97 62.5, 81.89 189.92, 10.32 -105.96, 31.62 305.32, 102.48 -65.13, -10.17 in-in in 8.313 Saltbr-in 2.938 HRD-in -68.69, -52.17 76.83, -16.13 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.5 APE8-rot-out 85.32 APE67-dihe-in -36.29, -45.18 -89.86, -8.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.239 0.248 B 415 393 4 0 0 4 [[76, 338]] 1.0 5hvu Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSB Q13464 6 402 1354.0 6U1:60501 Type1.5_Front Inactive DFGin 6.14 13.336 BLAminus DFGAsp-rot-in -142.66, 177.11 58.73, 60.85 198.24, -30.27 -80.32, 21.73 304.44, 101.0 -56.11, -39.34 in-in in 8.227 Saltbr-in 2.746 HRD-in -68.72, -42.28 78.49, -44.71 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -104.48, 133.16 APE9-dihe-na -95.73, 130.38 APE8-dihe-out 63.66, 89.81 APE8-rot-out 67.34 APE67-dihe-in -44.41, -53.62 -78.83, 5.04 APE12-dist-in 8.715 APE11-dist-in 12.174 APE10-dist-out 8.649 APE9-dist-out 10.213 None None None XRAY 3.3 0.215 0.254 B 415 394 0 0 0 0 [[76, 338]] 1.0 5kks Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTB Q13464 6 402 1354.0 6U2:60501 Type1.5_Front Inactive DFGin 6.306 13.599 BLAminus DFGAsp-rot-in -130.02, -177.11 50.1, 80.15 197.72, -0.81 -95.96, 18.23 299.48, 98.02 -62.02, -10.47 in-in in 8.889 Saltbr-in 2.78 HRD-in -68.38, -47.41 71.48, -14.73 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -110.61, 86.79 APE9-dihe-na -63.17, 97.09 APE8-dihe-out 74.12, 110.85 APE8-rot-in 316.95 APE67-dihe-in -53.36, -37.05 -91.57, 10.0 APE12-dist-in 8.432 APE11-dist-in 11.357 APE10-dist-out 10.199 APE9-dist-out 9.422 None None None XRAY 2.8 0.223 0.237 B 415 393 0 0 0 0 [[76, 338]] 1.0 5kkt Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEA Q13464 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus DFGAsp-rot-in -135.0, 175.35 53.04, 84.77 186.88, 58.35 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus DFGAsp-rot-in -143.39, 177.51 52.52, 73.92 190.34, 63.29 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEC Q13464 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus DFGAsp-rot-in -141.6, 173.01 60.67, 84.57 201.57, -2.47 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNED Q13464 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus DFGAsp-rot-in -136.38, 179.68 48.06, 76.76 196.48, 0.38 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.02 13.098 BLAminus DFGAsp-rot-in -129.77, 174.02 63.85, 83.94 193.25, 3.03 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.669 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.222 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399 377 13 0 0 7 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OG O75116 25 417 1388.0 5YK:501 Type1.5_Front Inactive DFGin 6.03 13.093 BLAminus DFGAsp-rot-in -130.18, 173.76 63.87, 84.33 192.84, 2.47 -107.4, 35.32 304.41, 101.68 -72.33, -45.62 in-in in 8.657 Saltbr-in 2.757 HRD-in -67.47, -41.36 68.16, 2.55 in-in-out SNCiio in-out ActLoopNT-in 3.223 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.99 APE67-dihe-in -56.93, -36.54 -73.99, -19.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 G 399 381 8 0 0 5 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.031 13.142 BLAminus DFGAsp-rot-in -130.18, 173.86 63.9, 84.23 193.08, 2.31 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.685 Saltbr-in 2.757 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.218 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399 369 19 0 0 14 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6B O75116 28 416 1388.0 J0P:501 Type1.5_Front Inactive DFGin 6.399 13.183 BLAminus DFGAsp-rot-in -141.53, 178.3 54.07, 109.38 181.19, -78.21 -133.99, 38.6 302.74, 88.83 -73.72, -23.58 in-in in 8.537 Saltbr-in 2.814 HRD-in -63.89, -44.38 75.08, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.55 APE8-dihe-in -56.82, 118.75 APE8-rot-in 295.99 APE67-dihe-in -40.0, -36.43 -89.99, -12.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.059 None None None XRAY 2.86 0.206 0.247 B 415 364 18 0 0 12 [[92, 354]] 1.0 6ed6 Homo sapiens AGC_ROCK2_HUMAN AGC 2.7e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSD O75116 24 417 1388.0 Z8O:501 Type1.5_Front Inactive DFGout 14.51 9.548 BBAminus DFGAsp-rot-in -103.86, 141.89 -103.51, 117.86 171.51, 42.11 -102.63, 25.16 306.33, 142.76 108.24, 20.62 out-none out 14.969 Saltbr-none 999.0 HRD-in -60.5, -48.74 68.07, -4.31 none-in-none SNCnin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 89.84 APE9-dihe-na 170.11, -172.34 APE8-dihe-in -98.69, 124.47 APE8-rot-in 291.85 APE67-dihe-in -51.67, -33.01 -41.58, -52.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.122 APE9-dist-in 4.517 None None None XRAY 2.71 0.218 0.248 D 396 379 10 0 0 5 [[92, 354]] 1.0 8gds Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
CAMK AURKA AURKA_HUMAN 6GRAA O14965 126 389 403.0 F8Z:501 Type1.5_Front Inactive DFGin 5.009 16.668 ABAminus DFGAsp-rot-out -83.94, -29.2 -118.43, -178.38 294.57, -77.49 -109.45, -4.58 278.61, 93.03 97.03, -121.48 out-out out 11.018 Saltbr-out 9.639 HRD-in -78.52, -51.2 68.01, 5.59 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 67.95 APE8-rot-none 999.0 APE67-dihe-in -48.59, -35.52 -71.59, -26.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.213 0.269 A 285 250 14 0 0 14 [[133, 383]] 1.0 6gra Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3M11A O14965 126 391 403.0 AKI:1 Type1.5_Front Inactive DFGin 6.963 16.704 BLAminus DFGAsp-rot-in -121.88, 165.26 64.27, 67.3 185.37, -16.53 -73.83, 6.74 288.37, 76.5 -59.9, -23.24 out-out out 11.142 Saltbr-out 7.507 HRD-out -96.16, 99.79 -59.97, -43.23 out-in-out SNCoio in-out ActLoopNT-in 3.401 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.15 APE8-dihe-in -53.14, 136.39 APE8-rot-in 259.54 APE67-dihe-in -40.98, -33.42 -92.04, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.255 T288D None None XRAY 2.75 0.221 0.299 A 279 256 10 0 0 10 [[133, 383]] 1.0 3m11 Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBPA O14965 126 390 403.0 YPH:501 Type1.5_Front Inactive DFGin 5.813 16.221 BLAminus DFGAsp-rot-in -117.4, 167.72 63.38, 95.52 189.71, -6.66 -104.02, 27.08 282.25, 81.8 -62.06, -18.61 out-out out 10.824 Saltbr-out 7.164 HRD-in -70.59, -54.13 72.42, 1.53 out-in-out SNCoio in-out ActLoopNT-in 3.475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 161.17 APE8-dihe-in -73.05, 143.32 APE8-rot-out 208.85 APE67-dihe-in -51.16, -32.61 -84.83, -4.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 T288D None None XRAY 2.45 0.226 0.291 A 279 255 10 0 0 10 [[133, 383]] 1.0 4jbp Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDA O14965 127 388 403.0 QMN:1389 Type1.5_Front Inactive DFGin 4.77 14.737 None DFGAsp-rot-in -129.81, 37.03 -50.55, -31.01 189.99, 29.16 -53.57, 125.59 325.32, 89.96 118.13, 999.0 out-out out 11.615 Saltbr-out 8.842 HRD-out 53.57, 64.67 -94.14, 134.34 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na -65.57, -29.93 APE9-dihe-na 142.25, -148.89 APE8-dihe-in -77.46, 105.91 APE8-rot-in 292.33 APE67-dihe-in -60.25, -12.9 -39.34, -60.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.598 None None None XRAY 3.2 0.215 0.262 A 287 254 8 0 0 8 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 8.1e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZDB O14965 125 389 403.0 QMN:1390 Type1.5_Front Inactive DFGin 4.576 14.72 None DFGAsp-rot-in -129.5, 39.33 -48.31, -42.14 198.54, 7.32 -43.39, 138.93 326.34, 95.13 97.81, -168.36 out-out out 11.585 Saltbr-out 9.397 HRD-out 50.88, 59.12 -92.12, 140.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.7, -29.88 APE9-dihe-na 143.96, -147.24 APE8-dihe-in -77.35, 106.49 APE8-rot-in 291.41 APE67-dihe-in -62.64, -12.41 -49.18, -49.73 APE12-dist-out 16.587 APE11-dist-out 15.405 APE10-dist-out 16.527 APE9-dist-out 9.503 None None None XRAY 3.2 0.215 0.262 B 287 258 7 0 0 7 [[133, 383]] 1.0 4uzd Homo sapiens CAMK_AURKA_HUMAN CAMK 8.1e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UYNA O14965 125 391 403.0 Y3M:1392 Type1.5_Front Inactive DFGin 4.695 14.011 None DFGAsp-rot-out -129.71, 33.27 -11.88, -124.06 106.65, -41.19 104.64, 86.61 36.8, 56.54 29.97, 999.0 out-out out 11.431 Saltbr-out 9.442 HRD-out 56.55, 66.12 -91.27, 149.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -53.31, -27.51 999.0, -36.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.201 0.234 A 287 249 18 0 0 16 [[133, 383]] 1.0 4uyn Homo sapiens CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.166 9.192 None DFGAsp-rot-in -114.69, 29.1 -93.31, 98.64 213.81, -64.46 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.504 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267 240 23 0 0 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.843 8.718 None DFGAsp-rot-out -97.71, -18.22 -58.8, 127.67 296.84, -65.8 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.752 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267 242 22 0 0 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.926 8.59 None DFGAsp-rot-in -120.45, 57.47 -126.6, 83.94 204.27, -76.74 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.771 Saltbr-out 9.688 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267 246 17 0 0 14 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.129 8.801 None DFGAsp-rot-in -108.79, 36.5 -105.08, 99.13 215.11, 89.31 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.868 Saltbr-out 9.636 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.327 None None None XRAY 2.0 0.285 0.351 B 267 249 15 0 0 11 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.493 None DFGAsp-rot-out -112.85, -19.21 -86.09, 145.25 84.13, -52.92 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.308 Saltbr-out 9.311 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.22 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285 256 11 0 0 11 [[133, 383]] 1.0 6hjj Homo sapiens CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.921 9.215 None DFGAsp-rot-in -125.94, 46.56 -78.14, 156.47 236.2, 69.99 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.863 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267 246 17 0 0 17 [[133, 383]] 1.0 3o51 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJKA O14965 127 391 403.0 G7W:501 Type1.5_Front Inactive DFGout 16.17 11.028 None DFGAsp-rot-out -98.89, -43.18 56.05, 51.38 278.3, -40.51 -26.46, 122.09 241.09, 49.93 -75.8, 146.41 out-none out 11.513 Saltbr-none 999.0 HRD-out -101.06, -164.07 153.73, -179.93 none-out-out SNCnoo out-out ActLoopNT-out 20.184 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -66.21 APE9-dihe-na -150.91, 1.99 APE8-dihe-out -109.25, 19.55 APE8-rot-in 313.76 APE67-dihe-in -56.8, -21.9 -54.42, -38.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.652 APE9-dist-out 13.829 L210C,C290A,C393A None None XRAY 2.4 0.219 0.252 A 285 255 10 0 0 10 [[133, 383]] 1.0 6hjk Homo sapiens CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6EB O14965 127 388 403.0 HPM:61388 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -108.73, 147.84 100.58, 999.0 257.72, -11.81 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.334 Saltbr-out 11.707 HRD-in -74.71, -88.37 86.19, 28.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.56 APE8-dihe-out -69.38, -179.33 APE8-rot-out 55.29 APE67-dihe-in -54.24, -12.3 -58.45, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.566 None None None XRAY 2.1 0.2 0.27 B 283 246 16 0 0 16 [[133, 383]] 1.0 2c6e Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKC AURKC_HUMAN 6GR8A Q9UQB9 36 303 309.0 F8Z:60401 Type1.5_Front Inactive DFGin 6.388 16.369 ABAminus DFGAsp-rot-in -86.33, -37.22 -148.5, 121.35 170.36, 20.14 -101.84, 15.84 276.95, 115.08 -62.41, -31.31 out-out out 10.659 Saltbr-out 7.756 HRD-in -76.6, -55.3 75.61, 5.87 out-in-out SNCoio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.48, 154.35 APE9-dihe-na 86.68, -167.53 APE8-dihe-in -103.19, 151.93 APE8-rot-out 71.83 APE67-dihe-in -66.94, -16.94 -38.52, -57.04 APE12-dist-in 8.161 APE11-dist-in 10.454 APE10-dist-in 5.38 APE9-dist-in 3.753 None TPO39,TPO198 TPO39,TPO198 XRAY 1.75 0.178 0.216 A 274 268 0 0 0 0 [[43, 293]] 1.0 6gr8 Homo sapiens CAMK_AURKC_HUMAN CAMK 1.1e-80 276.7 1 256 256 183 184 185 187 189 72 91 95 163 165 164 166 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
CAMK SIK3 SIK3_HUMAN 8R4UA Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.114 15.718 BLAminus DFGAsp-rot-in -120.83, 177.32 64.3, 69.36 208.49, -19.29 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.71 Saltbr-out 5.071 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.575 APE11-dist-in 10.839 APE10-dist-in 5.2 APE9-dist-in 3.515 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UC Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.064 15.726 BLAminus DFGAsp-rot-in -119.63, 172.69 64.17, 70.56 208.02, -18.54 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.634 Saltbr-out 5.218 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6 APE11-dist-in 10.767 APE10-dist-in 5.18 APE9-dist-in 3.513 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UE Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.17 15.536 BLAminus DFGAsp-rot-in -122.53, 178.95 58.14, 68.61 208.42, -19.02 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.651 Saltbr-out 5.131 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.534 APE11-dist-in 10.767 APE10-dist-in 5.184 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328 317 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN 8R4UG Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.045 15.697 BLAminus DFGAsp-rot-in -121.26, 171.88 69.65, 69.3 209.13, -19.4 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.772 Saltbr-out 5.165 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.813 APE10-dist-in 5.192 APE9-dist-in 3.424 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.9e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CMGC DYRK1A DYR1A_HUMAN 6EIJC Q13627 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus DFGAsp-rot-in -119.52, 178.29 74.66, 62.43 194.0, 15.07 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC MAPK1 MK01_HUMAN 6OPIA P28482 10 356 360.0 N0V:60401 Type1.5_Front None DFGin 6.816 16.494 BLAminus DFGAsp-rot-in -135.48, 169.13 71.03, 93.69 199.93, -40.15 -111.04, 34.22 293.24, 78.08 -67.49, -29.15 in-in in 9.892 Saltbr-in 3.054 HRD-in -72.72, -50.31 76.41, -2.79 in-in-none SNCiin in-none ActLoopNT-in 2.808 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.69 APE8-rot-in 306.85 APE67-dihe-in -62.81, -15.96 -67.99, -45.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO185,PTR187 TPO185,PTR187 XRAY 3.0 0.189 0.26 A 354 326 17 0 0 12 [[25, 313]] 1.0 6opi Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4QTAA P28482 10 358 360.0 38Z:411 Type1.5_Front Inactive DFGin 6.901 16.419 BLAminus DFGAsp-rot-in -127.54, 173.07 71.53, 87.6 197.52, -9.12 -104.51, 22.85 289.22, 73.36 -66.57, -25.44 in-in in 9.627 Saltbr-in 2.647 HRD-in -72.05, -50.52 77.72, -5.81 in-in-out SNCiio in-out ActLoopNT-in 2.787 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.19 APE8-rot-out 186.7 APE67-dihe-in -78.23, -10.32 -106.34, 7.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.45 0.16 0.191 A 361 335 14 0 0 14 [[25, 313]] 1.0 4qta Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9DA P28482 8 357 360.0 ER8:406 Type1.5_Front Inactive DFGin 6.832 16.417 BLAminus DFGAsp-rot-in -130.82, 177.58 62.78, 85.24 198.93, -5.3 -103.76, 20.35 283.71, 79.73 -63.11, -28.56 in-in in 9.944 Saltbr-in 2.634 HRD-in -73.65, -52.91 75.39, 8.67 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.6, -41.14 APE9-dihe-na -67.27, 166.02 APE8-dihe-in -67.59, 131.6 APE8-rot-in 309.39 APE67-dihe-in -67.26, -16.88 -58.97, -46.53 APE12-dist-out 14.47 APE11-dist-in 11.169 APE10-dist-in 7.005 APE9-dist-in 4.162 None None CME161 XRAY 1.8 0.169 0.223 A 368 346 0 0 0 0 [[25, 313]] 1.0 6g9d Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9HA P28482 11 357 360.0 ERW:405 Type1.5_Front Inactive DFGin 6.863 16.193 BLAminus DFGAsp-rot-in -129.54, 176.24 67.51, 84.59 190.02, -0.52 -100.67, 23.24 285.23, 76.32 -64.98, -24.84 out-in out 10.126 Saltbr-in 2.649 HRD-in -73.48, -50.99 74.79, 0.78 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.85, -36.75 APE9-dihe-na -71.44, 161.71 APE8-dihe-in -53.41, 125.25 APE8-rot-in 311.99 APE67-dihe-in -63.79, -17.26 -57.75, -47.59 APE12-dist-out 14.502 APE11-dist-in 11.198 APE10-dist-in 7.038 APE9-dist-in 4.328 None None CME161 XRAY 1.73 0.164 0.213 A 368 344 0 0 0 0 [[25, 313]] 1.0 6g9h Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9JA P28482 8 357 360.0 ERK:403 Type1.5_Front Inactive DFGin 6.852 16.45 BLAminus DFGAsp-rot-in -129.62, 174.38 66.65, 81.52 195.47, 2.95 -99.73, 19.69 286.36, 76.45 -66.94, -21.09 in-in in 9.657 Saltbr-in 2.72 HRD-in -69.57, -51.16 71.71, 3.51 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -94.41, -41.74 APE9-dihe-na -65.68, 165.5 APE8-dihe-in -68.67, 127.92 APE8-rot-in 310.31 APE67-dihe-in -68.75, -18.58 -53.05, -47.45 APE12-dist-out 14.709 APE11-dist-in 11.229 APE10-dist-in 7.162 APE9-dist-in 4.357 None None CME127,CME161,CME166 XRAY 1.98 0.162 0.212 A 368 350 0 0 0 0 [[25, 313]] 1.0 6g9j Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9KA P28482 11 357 360.0 ESK:404 Type1.5_Front Inactive DFGin 6.869 16.501 BLAminus DFGAsp-rot-in -127.44, 173.71 64.58, 89.87 195.69, 1.58 -103.62, 17.25 282.92, 76.11 -73.44, -14.72 in-in in 9.738 Saltbr-in 2.645 HRD-in -66.45, -52.24 73.55, 2.38 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.11, -41.06 APE9-dihe-na -64.16, 170.62 APE8-dihe-in -77.68, 128.75 APE8-rot-in 308.66 APE67-dihe-in -63.28, -19.27 -55.77, -50.47 APE12-dist-out 14.968 APE11-dist-in 11.461 APE10-dist-in 7.308 APE9-dist-in 4.294 None None CME127,CME161 XRAY 1.94 0.164 0.223 A 368 345 0 0 0 0 [[25, 313]] 1.0 6g9k Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6G9NA P28482 11 357 360.0 ESN:407 Type1.5_Front Inactive DFGin 7.133 16.526 BLAminus DFGAsp-rot-in -124.73, 175.13 63.57, 85.94 198.01, -15.91 -99.62, 16.39 282.24, 77.66 -74.35, -19.57 out-in out 10.165 Saltbr-in 2.75 HRD-in -70.0, -50.46 74.7, 7.06 in-in-out SNCiio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -65.54, 147.38 APE9-dihe-na 67.51, -176.26 APE8-dihe-in -97.0, 144.29 APE8-rot-in 289.97 APE67-dihe-in -64.18, -20.4 -49.42, -51.94 APE12-dist-in 13.633 APE11-dist-in 11.722 APE10-dist-out 9.01 APE9-dist-in 3.21 None None CME161 XRAY 1.76 0.168 0.218 A 368 345 0 0 0 0 [[25, 313]] 1.0 6g9n Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GDMA P28482 8 356 360.0 F3Z:404 Type1.5_Front Inactive DFGin 6.841 16.526 BLAminus DFGAsp-rot-in -126.95, 171.54 65.54, 87.24 199.32, -16.29 -101.62, 18.17 285.3, 73.79 -62.71, -23.55 in-in in 9.642 Saltbr-in 2.691 HRD-in -73.55, -51.55 74.53, 5.94 in-in-out SNCiio in-out ActLoopNT-in 2.769 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.91, -41.51 APE9-dihe-na -60.95, 166.12 APE8-dihe-in -74.95, 131.2 APE8-rot-in 307.5 APE67-dihe-in -60.9, -19.09 -57.69, -50.8 APE12-dist-out 14.652 APE11-dist-in 11.274 APE10-dist-in 7.213 APE9-dist-in 4.107 None None CME65,CME161,CME166,CME254 XRAY 1.91 0.185 0.243 A 368 345 0 0 0 0 [[25, 313]] 1.0 6gdm Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GE0A P28482 11 357 360.0 EVQ:406 Type1.5_Front Inactive DFGin 6.807 16.409 BLAminus DFGAsp-rot-in -125.01, 178.42 65.88, 86.44 192.64, -0.22 -104.81, 21.96 285.23, 73.29 -68.51, -20.31 in-in in 9.852 Saltbr-in 2.616 HRD-in -69.56, -50.3 73.32, 2.78 in-in-out SNCiio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.29, -38.81 APE9-dihe-na -61.85, 160.75 APE8-dihe-in -56.8, 124.98 APE8-rot-in 313.47 APE67-dihe-in -60.01, -18.82 -53.88, -51.43 APE12-dist-out 14.586 APE11-dist-in 11.277 APE10-dist-in 7.386 APE9-dist-in 4.33 None None CME127,CME161 XRAY 1.82 0.165 0.21 A 368 345 0 0 0 0 [[25, 313]] 1.0 6ge0 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6GJDA P28482 10 357 360.0 F0E:411 Type1.5_Front Inactive DFGin 6.71 16.462 BLAminus DFGAsp-rot-in -129.58, 174.41 70.7, 91.35 194.5, -12.77 -105.73, 20.26 284.72, 79.09 -64.64, -25.49 in-in in 9.62 Saltbr-in 2.671 HRD-in -72.09, -52.59 71.97, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.798 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.38, -38.44 APE9-dihe-na -62.52, 167.01 APE8-dihe-in -77.48, 126.95 APE8-rot-in 303.11 APE67-dihe-in -62.52, -19.79 -59.63, -41.94 APE12-dist-out 14.402 APE11-dist-in 11.242 APE10-dist-in 6.98 APE9-dist-in 4.093 None None CME161 XRAY 1.58 0.169 0.21 A 368 342 0 0 0 0 [[25, 313]] 1.0 6gjd Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7AUVA P28482 11 357 360.0 RYW:405 Type1.5_Front Inactive DFGin 7.023 16.575 BLAminus DFGAsp-rot-in -127.45, 177.69 56.53, 84.41 199.63, -13.51 -94.89, 19.78 285.74, 75.17 -78.04, -13.36 out-in out 10.23 Saltbr-in 2.72 HRD-in -72.53, -48.67 70.65, 1.51 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -92.76, -42.85 APE9-dihe-na -53.93, 163.97 APE8-dihe-in -75.48, 124.43 APE8-rot-in 308.53 APE67-dihe-in -70.04, -12.97 -52.3, -46.84 APE12-dist-out 14.989 APE11-dist-in 11.59 APE10-dist-in 7.384 APE9-dist-in 4.228 None None CME161 XRAY 1.76 0.17 0.229 A 368 347 0 0 0 0 [[25, 313]] 1.0 7auv Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQQA P28482 11 356 360.0 UMN:406 Type1.5_Front Inactive DFGin 6.918 16.492 BLAminus DFGAsp-rot-in -130.12, 174.13 62.32, 86.15 195.1, -0.73 -100.4, 23.58 286.24, 72.55 -69.75, -20.62 in-in in 9.469 Saltbr-in 2.678 HRD-in -65.77, -47.18 66.3, 4.45 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -99.75, -32.6 APE9-dihe-na -69.61, 163.37 APE8-dihe-in -60.6, 124.16 APE8-rot-in 315.24 APE67-dihe-in -60.72, -19.47 -52.29, -51.54 APE12-dist-out 14.8 APE11-dist-in 11.374 APE10-dist-in 7.402 APE9-dist-in 4.344 None None CME161 XRAY 1.943 0.177 0.228 A 368 342 0 0 0 0 [[25, 313]] 1.0 7nqq Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NQWA P28482 11 356 360.0 UNW:405 Type1.5_Front Inactive DFGin 6.816 16.419 BLAminus DFGAsp-rot-in -126.85, 178.18 67.17, 79.44 189.51, 12.54 -98.87, 21.06 284.86, 74.28 -63.45, -23.61 in-in in 9.783 Saltbr-in 2.511 HRD-in -71.96, -49.6 74.37, 1.07 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.4, -37.94 APE9-dihe-na -67.38, 158.88 APE8-dihe-in -52.66, 123.57 APE8-rot-in 311.73 APE67-dihe-in -63.22, -17.02 -54.57, -47.98 APE12-dist-out 14.626 APE11-dist-in 11.263 APE10-dist-in 7.186 APE9-dist-in 4.38 None None CME161 XRAY 1.775 0.167 0.206 A 368 346 0 0 0 0 [[25, 313]] 1.0 7nqw Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR5A P28482 11 357 360.0 UOH:405 Type1.5_Front Inactive DFGin 7.142 16.516 BLAminus DFGAsp-rot-in -128.99, 175.71 60.33, 87.75 197.73, -15.01 -101.3, 22.07 283.66, 79.18 -76.03, -20.46 out-in out 10.13 Saltbr-in 2.688 HRD-in -71.53, -48.61 67.4, 6.67 in-in-out SNCiio in-out ActLoopNT-in 2.832 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -66.22, 143.49 APE9-dihe-na 70.29, 179.11 APE8-dihe-in -86.54, 137.23 APE8-rot-in 294.6 APE67-dihe-in -64.14, -18.44 -44.13, -48.47 APE12-dist-in 13.395 APE11-dist-in 11.517 APE10-dist-out 9.146 APE9-dist-in 3.117 None None CME161 XRAY 1.766 0.176 0.223 A 368 342 0 0 0 0 [[25, 313]] 1.0 7nr5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR8A P28482 11 356 360.0 UOE:408 Type1.5_Front Inactive DFGin 6.789 16.622 BLAminus DFGAsp-rot-in -131.19, 173.71 59.31, 84.45 197.74, -15.45 -94.57, 22.79 284.69, 71.84 -65.62, -20.38 in-in in 9.992 Saltbr-in 2.554 HRD-in -71.25, -47.16 78.03, -4.67 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.57, -40.56 APE9-dihe-na -62.09, 161.08 APE8-dihe-in -53.56, 123.22 APE8-rot-in 309.14 APE67-dihe-in -64.63, -17.01 -54.92, -46.72 APE12-dist-out 14.771 APE11-dist-in 11.432 APE10-dist-in 7.445 APE9-dist-in 4.449 None None CME161 XRAY 1.627 0.173 0.213 A 368 346 0 0 0 0 [[25, 313]] 1.0 7nr8 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 7NR9A P28482 11 355 360.0 UOW:402 Type1.5_Front Inactive DFGin 7.179 16.445 BLAminus DFGAsp-rot-in -121.95, 178.87 51.29, 96.32 189.39, -17.12 -108.0, 26.49 285.39, 78.02 -83.88, -16.22 out-in out 10.206 Saltbr-in 3.273 HRD-in -66.46, -47.39 67.01, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -152.12, -19.83 APE9-dihe-na -57.71, 157.85 APE8-dihe-in -80.51, 146.4 APE8-rot-in 299.55 APE67-dihe-in -65.28, -14.73 -65.27, -45.43 APE12-dist-out 14.665 APE11-dist-in 11.277 APE10-dist-in 7.298 APE9-dist-in 3.56 None None CME161 XRAY 1.906 0.248 0.308 A 368 335 0 0 0 0 [[25, 313]] 1.0 7nr9 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3DA6A P53779 46 401 464.0 BZ9:1 Type1.5_Front Inactive DFGin 3.929 14.747 ABAminus DFGAsp-rot-out -106.52, -2.79 -134.69, 178.18 74.66, -45.22 -120.78, 7.15 305.58, 102.19 77.8, -154.0 out-out out 11.165 Saltbr-out 7.563 HRD-in -66.32, -64.11 78.04, -4.14 out-out-out SNCooo out-out ActLoopNT-out 7.545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 119.26 APE9-dihe-na -81.12, 139.86 APE8-dihe-in -90.77, 119.11 APE8-rot-out 151.47 APE67-dihe-in -57.67, -20.17 -106.88, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.829 None None None XRAY 2.0 0.259 0.32 A 364 328 12 0 0 10 [[64, 359]] 1.0 3da6 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4U79A P53779 44 400 464.0 3EL:501 Type1.5_Front Inactive DFGin 4.272 14.867 ABAminus DFGAsp-rot-out -89.42, -22.99 -142.11, 177.19 69.97, 42.48 -106.92, 6.69 291.05, 92.1 89.72, -154.87 out-out out 10.185 Saltbr-out 7.925 HRD-in -77.27, -59.41 68.42, 2.43 out-out-out SNCooo out-out ActLoopNT-out 6.442 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.02 APE8-dihe-in -101.3, 127.09 APE8-rot-out 123.68 APE67-dihe-in -52.45, -19.16 -120.61, -1.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.63 None None None XRAY 2.23 0.218 0.249 A 364 337 13 0 0 11 [[64, 359]] 1.0 4u79 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK3 MK03_HUMAN 4QTBA P27361 24 374 379.0 38Z:418 Type1.5_Front Inactive DFGin 6.963 16.192 BLAminus DFGAsp-rot-in -128.63, 172.06 72.12, 87.31 200.35, -19.7 -104.64, 23.58 286.23, 74.76 -64.07, -28.14 in-in in 9.638 Saltbr-in 2.654 HRD-in -72.11, -54.76 73.09, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.768 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -93.95, -29.12 APE9-dihe-na -67.78, 160.1 APE8-dihe-in -53.91, 125.98 APE8-rot-in 310.28 APE67-dihe-in -65.26, -17.27 -52.54, -50.1 APE12-dist-out 14.155 APE11-dist-in 10.804 APE10-dist-in 6.843 APE9-dist-in 4.412 None None None XRAY 1.4 0.148 0.175 A 380 351 0 0 0 0 [[42, 330]] 1.0 4qtb Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 4QTBB P27361 27 374 379.0 38Z:412 Type1.5_Front Inactive DFGin 6.989 16.095 BLAminus DFGAsp-rot-in -131.38, 169.9 76.01, 86.99 200.97, -17.02 -105.18, 21.27 288.36, 77.86 -59.51, -32.2 in-in in 9.594 Saltbr-in 2.709 HRD-in -72.51, -53.5 77.51, 5.81 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -90.9, -27.9 APE9-dihe-na -67.55, 157.04 APE8-dihe-in -54.84, 126.95 APE8-rot-in 308.82 APE67-dihe-in -67.72, -16.58 -53.94, -47.75 APE12-dist-out 14.188 APE11-dist-in 10.858 APE10-dist-in 7.082 APE9-dist-in 4.411 None None None XRAY 1.4 0.148 0.175 B 380 348 0 0 0 0 [[42, 330]] 1.0 4qtb Homo sapiens CMGC_MAPK3_HUMAN CMGC 3.3e-87 298.5 1 301 301 183 184 185 187 189 71 88 92 163 165 164 166 227 214 209 208 207 206 205 204 203 123 Mitogen-activated protein kinase 3
CMGC MAPK7 MK07_HUMAN 6HKNA Q13164 54 393 816.0 G9E:1001 Type1.5_Front Inactive DFGin 6.803 16.175 BLAminus DFGAsp-rot-out -129.91, -177.31 56.69, 71.23 287.82, -19.93 -86.37, 9.05 284.58, 84.05 -53.54, -30.22 out-out out 10.182 Saltbr-out 5.893 HRD-in -68.18, -48.7 72.35, -1.17 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -68.45, 121.21 APE9-dihe-na 64.95, -147.27 APE8-dihe-in -100.08, 133.81 APE8-rot-in 310.44 APE67-dihe-in -63.59, -21.47 -60.08, -43.48 APE12-dist-out 14.878 APE11-dist-in 11.693 APE10-dist-in 7.73 APE9-dist-in 4.463 None None None XRAY 2.33 0.209 0.249 A 340 333 7 0 0 0 [[55, 347]] 1.0 6hkn Homo sapiens CMGC_MAPK7_HUMAN CMGC 6e-82 281.4 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 6HKMA Q13164 54 395 816.0 G92:1001 Type1.5_Front Inactive DFGin 6.803 15.84 BLAminus DFGAsp-rot-out -123.75, -172.09 56.25, 77.83 302.45, 79.5 -101.07, 16.04 286.41, 85.42 -62.88, -24.07 in-out in 9.919 Saltbr-out 4.891 HRD-in -70.02, -49.84 71.12, 8.12 out-in-out SNCoio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -78.44, 115.75 APE9-dihe-na 70.91, -145.41 APE8-dihe-in -108.32, 133.47 APE8-rot-out 174.14 APE67-dihe-in -68.29, -14.88 -60.97, -41.94 APE12-dist-out 14.71 APE11-dist-in 11.45 APE10-dist-in 7.56 APE9-dist-in 4.281 None None None XRAY 2.47 0.222 0.28 A 347 327 15 0 0 2 [[55, 347]] 1.0 6hkm Homo sapiens CMGC_MAPK7_HUMAN CMGC 6.5e-82 281.3 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
OTHER ERN1 ERN1_HUMAN 6W3EA O75460 562 962 977.0 SJV:1001 Type1.5_Front Inactive DFGin 5.559 15.899 BLAminus DFGAsp-rot-out -140.85, 172.03 60.0, 89.13 289.15, -33.3 -100.99, 31.09 302.24, 167.69 86.31, 999.0 out-out out 10.584 Saltbr-out 7.056 HRD-out -78.48, 138.54 -121.69, -39.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 110.12, -20.7 999.0, 1.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.737 0.267 0.317 A 431 366 31 0 0 21 [[571, 832]] 1.0 6w3e Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6XDDA O75460 560 963 977.0 N97:1001 Type1.5_Front Inactive DFGin 5.489 15.205 BLAminus DFGAsp-rot-out -139.2, -157.42 53.89, 65.22 274.02, 87.33 -88.09, 16.93 282.86, 65.69 -65.77, -21.13 out-out out 11.188 Saltbr-out 12.042 HRD-in -80.68, -53.29 75.03, 2.35 out-in-out SNCoio in-out ActLoopNT-in 2.911 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oiio APE10-dihe-na -59.07, 142.31 APE9-dihe-na -71.86, -26.93 APE8-dihe-in -99.41, 120.0 APE8-rot-in 319.4 APE67-dihe-out 115.13, -26.59 -99.28, -175.8 APE12-dist-out 6.004 APE11-dist-in 9.114 APE10-dist-in 7.347 APE9-dist-out 9.016 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.4 0.2 0.238 A 434 404 0 0 0 0 [[571, 832]] 1.0 6xdd Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 8UVLA O75460 562 964 977.0 XOE:1009 Type1.5_Front Inactive DFGin 4.499 14.81 BLAminus DFGAsp-rot-in -137.56, -175.69 71.07, 82.79 202.33, -9.91 -97.11, 15.73 276.96, 54.31 -66.64, -22.13 out-out out 12.069 Saltbr-out 11.269 HRD-in -84.52, -50.1 80.24, 0.69 out-in-out SNCoio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.36, -16.47 APE9-dihe-na 124.74, -153.73 APE8-dihe-in -111.02, 130.63 APE8-rot-in 288.72 APE67-dihe-inflip 102.08, -11.75 -58.44, 133.55 APE12-dist-in 7.721 APE11-dist-out 7.141 APE10-dist-out 10.097 APE9-dist-in 3.899 None None None XRAY 2.43 0.184 0.251 A 448 403 0 0 0 0 [[571, 832]] 1.0 8uvl Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-34 124.6 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER HASPIN HASP_HUMAN 6Z5AA Q8TF76 465 798 798.0 Q8B:60807 Type1.5_Front Inactive DFGin 4.746 13.158 BLAminus DFGAsp-rot-in -130.52, 170.23 77.78, 97.19 195.47, -11.53 -110.55, 22.86 309.49, 126.33 -50.19, -42.61 out-out out 10.928 Saltbr-out 6.049 HRD-na-N -69.87, -51.48 73.76, 2.92 out-in-na SNCoia in-na ActLoopNT-in 2.957 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -114.05, 16.57 APE9-dihe-na -70.55, 162.23 APE8-dihe-na -152.03, 159.2 APE8-rot-na 218.93 APE67-dihe-na -157.88, 144.9 96.43, 3.83 APE12-dist-na 9.408 APE11-dist-na 13.313 APE10-dist-na 16.953 APE9-dist-na 12.968 None None None XRAY 1.55 0.157 0.182 A 357 334 0 0 0 0 [[484, 797]] 1.0 6z5a Homo sapiens OTHER_HASPIN_HUMAN HASP 1.4e-226 756.6 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 6TNBA P33981 517 794 857.0 8QW:901 Type1.5_Front Inactive DFGin 3.852 15.094 ABAminus DFGAsp-rot-out -120.69, -13.19 -153.82, 168.98 72.21, -21.11 -122.43, 7.93 296.97, 146.25 65.5, 17.91 out-out out 11.011 Saltbr-out 8.542 HRD-in -60.06, -45.03 76.67, -3.67 out-out-out SNCooo out-out ActLoopNT-out 12.114 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 47.02 APE8-dihe-in -74.89, 162.5 APE8-rot-none 999.0 APE67-dihe-in -76.36, -29.64 -145.32, 10.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.114 None TPO686 TPO686 XRAY 2.65 0.215 0.262 A 294 252 26 0 0 15 [[525, 791]] 1.0 6tnb Homo sapiens OTHER_TTK_HUMAN CAMK 6.8e-54 188.9 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N9SA P33981 519 794 857.0 8QW:60901 Type1.5_Front Inactive DFGin 3.866 14.796 ABAminus DFGAsp-rot-out -103.91, -21.18 -148.36, 167.12 78.16, -46.47 -113.73, -1.29 297.53, 126.79 78.88, 15.58 out-out out 10.96 Saltbr-out 9.124 HRD-in -76.88, -53.0 67.73, 3.84 out-out-out SNCooo out-out ActLoopNT-out 11.817 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na 176.56, 127.56 APE9-dihe-na 70.2, 2.51 APE8-dihe-in -61.92, 151.57 APE8-rot-none 999.0 APE67-dihe-in -61.07, -20.0 -114.51, -10.18 APE12-dist-out 19.555 APE11-dist-out 17.191 APE10-dist-out 14.162 APE9-dist-out 10.05 None TPO686 TPO686 XRAY 2.3 0.194 0.245 A 313 257 19 0 0 7 [[525, 791]] 1.0 5n9s Homo sapiens OTHER_TTK_HUMAN CAMK 8.6e-54 188.7 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
STE MAP2K7 MP2K7_HUMAN 7OVIA O14733 102 402 419.0 2GI:60501 Type1.5_Front Inactive DFGin 4.755 13.599 BLAplus DFGAsp-rot-out -140.91, 171.28 50.96, 52.63 291.6, -38.89 -104.5, 0.42 42.65, 71.15 -92.35, -151.25 na-na na 9.793 Saltbr-na 8.346 HRD-out -95.23, 128.06 -114.34, -2.31 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.25 A 318 262 39 0 0 23 [[120, 380]] 1.0 7ovi Homo sapiens STE_MAP2K7_HUMAN STE 2.8e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7OVJA O14733 102 403 419.0 24N:60501 Type1.5_Front Inactive DFGin 5.238 14.04 BLBplus DFGAsp-rot-out -149.66, 173.75 53.03, 68.8 281.82, -31.25 -120.16, 126.9 30.41, 81.15 125.32, 999.0 na-na na 9.497 Saltbr-na 8.403 HRD-in -63.57, -57.01 68.81, 21.85 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.2 APE8-dihe-in -71.05, 126.52 APE8-rot-na 187.98 APE67-dihe-in -67.38, -26.76 -67.11, -24.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.191 None None None XRAY 2.35 0.204 0.244 A 318 276 26 0 0 15 [[120, 380]] 1.0 7ovj Homo sapiens STE_MAP2K7_HUMAN STE 2.8e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6IB2A O14733 102 401 419.0 862:60501 Type1.5_Front Inactive DFGin 5.276 14.073 None DFGAsp-rot-in -91.61, -76.02 -109.31, 164.08 205.62, -36.22 -125.38, 999.0 315.5, 111.59 999.0, 999.0 na-na na 9.927 Saltbr-na 8.349 HRD-out -68.06, 100.79 -82.59, 24.57 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -28.73 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.224 0.25 A 318 265 35 0 0 19 [[120, 380]] 1.0 6ib2 Homo sapiens STE_MAP2K7_HUMAN STE 3.2e-80 275.2 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE PAK1 PAK1_HUMAN 5DFPA Q13153 249 541 545.0 59U:601 Type1.5_Front Inactive DFGin 7.083 16.69 BLAminus DFGAsp-rot-in -140.33, 175.32 61.17, 77.14 201.86, -19.09 -92.35, 18.95 281.32, 71.97 -52.66, -30.78 out-none out 10.13 Saltbr-none 999.0 HRD-in -72.71, -47.47 77.58, -9.24 none-in-in SNCnii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.23, -24.32 APE9-dihe-na -78.24, 174.02 APE8-dihe-in -76.36, 125.32 APE8-rot-in 314.95 APE67-dihe-in -61.02, -19.58 -40.67, -55.78 APE12-dist-in 8.892 APE11-dist-in 11.038 APE10-dist-in 5.024 APE9-dist-in 3.405 K299R TPO423 TPO423 XRAY 2.2 0.193 0.246 A 297 293 0 0 0 0 [[270, 521]] 1.0 5dfp Homo sapiens STE_PAK1_HUMAN STE 7.5e-95 323.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.32 10.343 BBAminus DFGAsp-rot-in -126.87, -173.24 -145.98, 95.31 190.47, -25.67 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303 272 19 0 0 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.363 10.386 BBAminus DFGAsp-rot-in -130.09, -171.07 -147.42, 95.57 190.72, -23.79 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.713 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.404 None None None XRAY 2.6 0.224 0.255 B 303 275 17 0 0 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK10 STK10_HUMAN 7QGPA O94804 23 313 968.0 DJ8:401 Type1.5_Front Inactive DFGin 6.63 15.647 BLBminus DFGAsp-rot-in -137.41, 176.17 64.63, 46.3 206.91, 12.85 -55.04, 138.14 280.95, 68.0 -53.28, 137.64 in-out in 8.416 Saltbr-out 10.651 HRD-in -69.38, -55.58 84.71, -10.94 out-out-out SNCooo out-out ActLoopNT-out 11.032 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioo APE10-dihe-na -131.79, 8.52 APE9-dihe-na 91.31, 163.78 APE8-dihe-in -62.99, 130.71 APE8-rot-in 298.17 APE67-dihe-out -58.73, -25.46 -85.93, 65.94 APE12-dist-in 12.317 APE11-dist-in 13.564 APE10-dist-out 8.716 APE9-dist-out 11.288 None None None XRAY 1.9 0.201 0.237 A 302 288 3 0 0 0 [[36, 294]] 1.0 7qgp Homo sapiens STE_STK10_HUMAN STE 4.8e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK24 STK24_HUMAN 7B30A Q9Y6E0 26 301 443.0 59T:60401 Type1.5_Front Inactive DFGin 5.998 16.341 BLBminus DFGAsp-rot-out -142.66, 171.86 53.27, 62.4 279.35, -7.02 -55.16, 145.73 286.02, 54.35 -77.45, 152.93 out-out out 10.152 Saltbr-out 5.155 HRD-in -71.84, -49.63 80.65, -3.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.97 APE8-rot-out 199.34 APE67-dihe-in -62.34, -30.7 -96.14, -7.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.178 0.196 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b30 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B31A Q9Y6E0 26 301 443.0 SQ8:60401 Type1.5_Front Inactive DFGin 5.963 16.341 BLBminus DFGAsp-rot-out -140.7, 175.65 52.28, 60.52 276.6, -7.1 -54.42, 142.35 285.4, 61.46 -75.74, 160.64 out-out out 10.162 Saltbr-out 5.212 HRD-in -69.31, -49.87 81.3, -4.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.03 APE8-rot-out 170.11 APE67-dihe-in -67.52, -27.96 -93.98, -4.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.178 0.212 A 306 260 16 0 0 15 [[36, 286]] 1.0 7b31 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B32A Q9Y6E0 26 301 443.0 SQQ:60401 Type1.5_Front Inactive DFGin 5.994 16.506 BLBminus DFGAsp-rot-out -139.7, 173.68 52.58, 62.82 279.25, -8.3 -58.11, 145.21 283.84, 55.87 -74.74, 156.53 out-out out 10.247 Saltbr-out 5.257 HRD-in -70.06, -50.26 83.03, -8.41 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.41 APE8-rot-out 171.24 APE67-dihe-in -64.92, -27.84 -92.4, -6.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.176 0.203 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b32 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B33A Q9Y6E0 26 301 443.0 SQE:60905 Type1.5_Front Inactive DFGin 5.91 16.194 BLBminus DFGAsp-rot-out -141.17, 175.88 52.44, 59.58 279.1, -12.74 -53.5, 142.51 285.89, 62.08 -74.39, 158.17 out-out out 10.226 Saltbr-out 5.306 HRD-in -70.12, -49.24 81.27, -6.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.19 APE8-rot-out 184.46 APE67-dihe-in -66.19, -27.5 -93.44, -7.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.182 0.208 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b33 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B34A Q9Y6E0 26 301 443.0 SQK:60608 Type1.5_Front Inactive DFGin 5.982 16.334 BLBminus DFGAsp-rot-out -147.82, -179.56 47.7, 64.7 275.56, -11.15 -58.67, 144.27 284.06, 64.99 -79.61, 160.22 out-out out 10.231 Saltbr-out 5.075 HRD-in -70.42, -53.51 88.4, -7.12 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.81 APE8-rot-out 203.11 APE67-dihe-in -61.35, -31.31 -94.67, -11.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.191 0.215 A 306 259 17 0 0 15 [[36, 286]] 1.0 7b34 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35A Q9Y6E0 26 301 443.0 SQB:60401 Type1.5_Front Inactive DFGin 5.824 16.212 BLBminus DFGAsp-rot-out -141.79, 178.75 47.82, 66.16 272.95, -10.96 -66.86, 142.85 279.77, 46.45 -79.99, 160.94 out-out out 10.147 Saltbr-out 5.385 HRD-in -75.69, -45.29 76.32, -1.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 134.05 APE8-rot-out 51.17 APE67-dihe-in -63.93, -31.26 -96.22, 7.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.263 A 306 261 15 0 0 15 [[36, 286]] 1.0 7b35 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 7B35B Q9Y6E0 26 301 443.0 SQB:60401 Type1.5_Front Inactive DFGin 5.949 16.202 BLBminus DFGAsp-rot-out -142.08, 177.83 50.7, 59.46 271.7, -15.31 -61.4, 147.78 284.16, 55.56 -80.3, 162.91 out-out out 10.12 Saltbr-out 5.12 HRD-in -73.73, -40.61 75.9, -3.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.95 APE8-rot-out 172.46 APE67-dihe-in -66.86, -22.7 -94.71, -1.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.263 B 306 261 15 0 0 15 [[36, 286]] 1.0 7b35 Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8BZJB Q9Y6E0 26 301 443.0 SJX:60401 Type1.5_Front Inactive DFGin 5.978 16.498 BLBminus DFGAsp-rot-out -134.62, -178.8 42.57, 68.83 299.39, -79.84 -59.18, 156.04 283.69, 69.22 -85.7, 141.9 out-out out 10.293 Saltbr-out 5.207 HRD-in -67.7, -47.74 83.43, -18.78 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.33 APE8-rot-in 295.22 APE67-dihe-in -62.19, -30.29 -95.02, -12.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.52 0.185 0.25 B 306 261 15 0 0 15 [[36, 286]] 1.0 8bzj Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRA Q9Y6E0 26 301 443.0 VYN:60401 Type1.5_Front Inactive DFGin 5.781 16.292 BLBminus DFGAsp-rot-out -139.31, 171.02 54.18, 66.37 284.86, -56.76 -60.4, 145.29 286.55, 53.64 -76.98, 163.2 out-out out 10.244 Saltbr-out 5.329 HRD-in -64.82, -50.81 83.77, -6.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.94 APE8-rot-out 186.72 APE67-dihe-in -63.37, -30.26 -94.36, -2.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.181 0.217 A 306 261 15 0 0 15 [[36, 286]] 1.0 8qlr Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLRB Q9Y6E0 26 301 443.0 VYN:60401 Type1.5_Front Inactive DFGin 5.739 16.377 BLBminus DFGAsp-rot-out -139.86, 177.24 47.6, 68.2 287.82, -64.78 -64.36, 146.73 282.24, 52.97 -75.84, 163.34 out-out out 10.251 Saltbr-out 5.252 HRD-in -68.7, -49.83 79.32, -3.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.74 APE8-rot-out 167.72 APE67-dihe-in -61.97, -27.51 -94.87, 0.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.181 0.217 B 306 259 17 0 0 15 [[36, 286]] 1.0 8qlr Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLSA Q9Y6E0 26 301 443.0 VYH:60401 Type1.5_Front Inactive DFGin 5.681 16.179 BLBminus DFGAsp-rot-out -139.23, 174.31 56.75, 63.77 290.26, -67.58 -56.08, 144.93 290.16, 67.75 -77.65, 157.52 out-out out 10.178 Saltbr-out 5.276 HRD-in -68.48, -51.67 82.32, -8.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.2 APE8-rot-out 176.47 APE67-dihe-in -65.65, -27.09 -96.29, -4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.61 0.151 0.184 A 306 261 15 0 0 15 [[36, 286]] 1.0 8qls Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 8QLTA Q9Y6E0 25 301 443.0 VZ2:60401 Type1.5_Front Inactive DFGin 5.789 16.276 BLBminus DFGAsp-rot-out -138.52, 170.04 55.04, 64.79 288.0, -65.16 -59.22, 147.63 285.87, 54.67 -80.11, 162.03 out-out out 10.123 Saltbr-out 5.238 HRD-in -67.15, -49.85 79.68, -8.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.14 APE8-rot-out 188.98 APE67-dihe-in -61.86, -29.94 -97.55, -6.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.47 0.153 0.176 A 306 261 16 0 0 15 [[36, 286]] 1.0 8qlt Homo sapiens STE_STK24_HUMAN STE 3.8e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK26 STK26_HUMAN 7B36A Q9P289 18 300 416.0 59T:703 Type1.5_Front Inactive DFGin 5.918 16.497 BLBminus DFGAsp-rot-out -143.98, 170.7 56.84, 62.11 272.78, -5.98 -60.85, 154.55 283.92, 44.19 -84.52, 163.38 out-out out 10.529 Saltbr-out 5.434 HRD-in -65.72, -54.18 91.14, -9.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.53 APE8-dihe-in -102.71, 115.66 APE8-rot-out 39.32 APE67-dihe-in -69.82, -27.39 -95.85, 15.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.835 None None None XRAY 2.107 0.203 0.244 A 301 268 15 0 0 14 [[24, 274]] 1.0 7b36 Homo sapiens STE_STK26_HUMAN STE 3.6e-100 340.6 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus DFGAsp-rot-in -134.39, 177.59 74.52, 87.23 200.43, -15.44 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3.1e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL MAP3K20 M3K20_HUMAN 7YAWB Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 6.061 12.887 BLAplus DFGAsp-rot-in -112.26, 159.46 66.47, 30.72 211.28, 36.86 -77.06, -4.03 46.81, 82.8 -112.18, 3.53 out-out out 16.198 Saltbr-out 14.385 HRD-in -68.93, -58.68 76.93, -11.19 out-out-out SNCooo out-out ActLoopNT-out 5.841 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -56.67, -41.74 APE9-dihe-na -72.55, 0.42 APE8-dihe-out -131.57, -4.4 APE8-rot-out 77.42 APE67-dihe-in -62.57, -21.79 -53.81, -31.98 APE12-dist-out 14.667 APE11-dist-out 14.027 APE10-dist-out 18.493 APE9-dist-out 12.46 None None None XRAY 2.1 0.208 0.243 B 310 291 1 0 0 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL MAP3K20 M3K20_HUMAN 7YAWC Q9NYL2 8 299 800.0 IGS:60401 Type1.5_Front Inactive DFGin 5.677 12.984 BLAplus DFGAsp-rot-in -105.78, 161.9 66.78, 23.82 199.54, 49.64 -68.46, -14.89 48.8, 88.46 -104.69, -15.53 out-out out 16.089 Saltbr-out 16.095 HRD-in -71.18, -58.92 73.09, -4.85 out-out-out SNCooo out-out ActLoopNT-out 5.616 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -67.62, -51.34 APE9-dihe-na -86.7, 18.29 APE8-dihe-out -115.5, -10.48 APE8-rot-in 308.5 APE67-dihe-in -59.14, -22.29 -53.59, -37.71 APE12-dist-out 14.986 APE11-dist-in 13.949 APE10-dist-out 18.373 APE9-dist-out 12.303 None None None XRAY 2.1 0.208 0.243 C 310 291 1 0 0 1 [[16, 262]] 1.0 7yaw Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.4 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL RIPK3 RIPK3_HUMAN 7MONB Q9Y572 5 311 518.0 ZL1:401 Type1.5_Front Inactive DFGin 5.319 12.898 BLBplus DFGAsp-rot-out -139.6, 164.18 56.61, 37.55 284.23, -25.27 -80.29, 166.6 34.44, 92.89 79.72, -103.63 out-out out 11.648 Saltbr-out 7.413 HRD-in -76.18, -40.34 61.78, -4.08 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na 97.81, 14.44 APE9-dihe-na -63.58, 158.11 APE8-dihe-out -64.13, -29.56 APE8-rot-in 301.21 APE67-dihe-in -66.2, -17.44 -59.33, -40.24 APE12-dist-out 18.646 APE11-dist-out 21.316 APE10-dist-out 17.042 APE9-dist-out 10.554 C3S,C110A TPO224,SEP227 TPO224,SEP227 XRAY 2.23 0.212 0.26 B 316 285 22 0 0 12 [[21, 285]] 1.0 7mon Homo sapiens TKL_RIPK3_HUMAN TKL 7.4e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TYR ABL1 ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None DFGAsp-rot-out -68.71, 128.66 -122.3, 46.03 51.01, 2.09 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-na 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None DFGAsp-rot-out -74.12, 129.26 -121.25, 39.81 53.04, -9.3 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-na 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None DFGAsp-rot-out -72.67, 142.35 -137.94, 44.53 59.76, -14.4 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-na 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None DFGAsp-rot-out -69.26, 149.18 -127.32, 25.05 44.91, 11.91 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-na 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 4JOAA Q9UM73 1107 1398 1620.0 3DK:1501 Type1.5_Front Inactive DFGin 5.651 15.18 ABAminus DFGAsp-rot-in -99.28, -25.44 -116.97, 136.23 188.11, -80.67 -132.09, 28.46 289.09, 82.31 -66.18, -40.48 in-out in 8.532 Saltbr-out 7.323 HRD-in -79.35, -45.13 67.79, 9.59 out-out-out SNCooo out-out ActLoopNT-out 6.633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -75.97, -11.03 APE9-dihe-in -75.81, 135.85 APE8-dihe-in -79.69, 75.84 APE8-rot-na 32.08 APE67-dihe-in -70.53, -20.07 -69.09, -33.02 APE12-dist-na 999.0 APE11-dist-na 15.099 APE10-dist-na 10.28 APE9-dist-na 8.098 S1281G None None XRAY 2.7 0.253 0.29 A 344 251 41 0 0 9 [[1116, 1385]] 1.0 4joa Homo sapiens TYR_ALK_HUMAN TYR 5.1e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 3W2OA P00533 698 1017 1210.0 03P:61101 Type1.5_Front Inactive DFGin 6.063 16.853 BLAminus DFGAsp-rot-in -136.96, -170.56 62.22, 87.75 195.09, -21.25 -101.43, 18.89 291.4, 91.83 -57.44, -26.38 out-out out 10.675 Saltbr-out 8.523 HRD-in -77.47, -53.25 75.27, 2.22 out-in-in SNCoii in-in ActLoopNT-in 2.888 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -73.73, 104.36 APE9-dihe-in -123.36, 141.58 APE8-dihe-in -79.92, 73.45 APE8-rot-na 24.57 APE67-dihe-in -74.19, -6.86 -50.44, -40.99 APE12-dist-na 11.686 APE11-dist-na 11.26 APE10-dist-na 10.559 APE9-dist-na 7.223 T790M,L858R None None XRAY 2.35 0.182 0.216 A 331 304 0 0 0 0 [[712, 970]] 1.0 3w2o Homo sapiens TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2PA P00533 698 1018 1210.0 W2P:61101 Type1.5_Front Inactive DFGin 6.166 17.253 BLAminus DFGAsp-rot-in -131.72, -170.04 61.76, 87.11 193.27, -27.38 -100.15, 22.27 288.83, 85.51 -59.78, -24.55 out-out out 10.896 Saltbr-out 9.197 HRD-in -74.33, -49.37 70.61, 3.25 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -98.88, 109.86 APE9-dihe-in -115.54, 146.26 APE8-dihe-in -77.33, 72.71 APE8-rot-na 32.52 APE67-dihe-in -72.04, -9.29 -47.42, -44.04 APE12-dist-na 11.857 APE11-dist-na 11.036 APE10-dist-na 11.483 APE9-dist-na 7.134 T790M,L858R None None XRAY 2.05 0.181 0.206 A 331 307 0 0 0 0 [[712, 970]] 1.0 3w2p Homo sapiens TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3W2QA P00533 698 1017 1210.0 HKI:61101 Type1.5_Front Inactive DFGin 6.184 16.72 BLAminus DFGAsp-rot-in -130.59, -173.46 61.6, 82.75 194.61, -17.8 -98.16, 22.05 287.41, 85.18 -65.26, -18.03 out-out out 10.536 Saltbr-out 5.753 HRD-in -77.64, -48.42 70.13, 4.48 out-in-in SNCoii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.12, 121.01 APE9-dihe-in -124.15, 141.54 APE8-dihe-in -80.25, 75.51 APE8-rot-na 32.95 APE67-dihe-in -72.98, -8.46 -42.37, -46.09 APE12-dist-na 12.571 APE11-dist-na 10.333 APE10-dist-na 10.606 APE9-dist-na 7.01 T790M,L858R None None XRAY 2.2 0.177 0.2 A 331 306 0 0 0 0 [[712, 970]] 1.0 3w2q Homo sapiens TYR_EGFR_HUMAN TYR 9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKC P00533 701 1014 1210.0 TQA:1301 Type1.5_Front Inactive DFGin 4.108 14.307 BLBplus DFGAsp-rot-out -128.74, 170.35 57.84, 42.31 288.35, 8.06 -80.67, 146.74 56.84, 84.42 73.11, 52.84 out-out out 13.687 Saltbr-out 13.168 HRD-in -69.35, -57.7 81.97, -4.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -99.43 APE9-dihe-in -140.88, 118.68 APE8-dihe-in -72.34, 69.57 APE8-rot-na 41.21 APE67-dihe-in -76.32, 0.41 -56.53, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.489 APE9-dist-na 8.042 T790M,V948R None None XRAY 2.4 0.219 0.23 C 328 299 15 0 0 15 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNC P00533 701 1014 1210.0 UEJ:1301 Type1.5_Front Inactive DFGin 5.149 14.242 BLBplus DFGAsp-rot-out -125.79, 168.58 69.11, 30.42 286.81, 3.3 -73.13, 126.76 42.33, 95.66 91.61, -9.41 out-out out 13.559 Saltbr-out 12.827 HRD-in -75.25, -56.93 84.93, -23.09 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.4 APE8-dihe-in -83.07, 65.64 APE8-rot-na 32.78 APE67-dihe-in -77.0, -5.94 -52.82, -37.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.347 T790M,V948R None None XRAY 1.76 0.209 0.235 C 328 286 28 0 0 16 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXND P00533 702 1014 1210.0 UEJ:1101 Type1.5_Front Inactive DFGin 5.021 14.15 BLBplus DFGAsp-rot-out -127.07, 163.26 73.25, 22.29 286.6, 3.56 -63.33, 141.68 45.73, 93.45 80.75, -14.01 out-out out 13.653 Saltbr-out 13.598 HRD-in -75.42, -56.41 82.09, -17.01 out-out-none SNCoon out-none ActLoopNT-out 6.661 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.16 APE8-dihe-in -83.51, 70.14 APE8-rot-na 34.07 APE67-dihe-in -73.61, -7.52 -55.72, -38.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.723 T790M,V948R None None XRAY 1.76 0.209 0.235 D 328 292 16 0 0 13 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3A P00533 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus DFGAsp-rot-out -135.94, 169.11 67.48, 22.01 287.05, -58.05 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-none SNCoon out-none ActLoopNT-out 8.667 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8PO3A P00533 706 1001 1210.0 2II:1101 Type1.5_Front Inactive DFGin 5.664 17.494 BLBtrans DFGAsp-rot-out -107.39, 172.75 67.19, 30.39 282.71, -22.83 -61.3, 132.08 163.82, 77.02 76.73, -7.92 out-out out 15.498 Saltbr-out 15.217 HRD-in -73.05, -52.43 81.25, -11.07 out-out-none SNCoon out-none ActLoopNT-out 6.766 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.29 APE8-dihe-in -83.1, 70.29 APE8-rot-na 33.27 APE67-dihe-in -73.75, -3.18 -47.3, -43.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.215 V948R None None XRAY 2.13 0.222 0.269 A 330 279 13 0 0 13 [[712, 970]] 1.0 8po3 Homo sapiens TYR_EGFR_HUMAN TYR 8.3e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR FGFR3 FGFR3_HUMAN 8UDUB P22607 459 755 806.0 WIQ:61002 Type1.5_Front Active DFGin 6.421 14.415 BLAminus DFGAsp-rot-in -138.69, 176.26 64.2, 86.01 192.54, -15.43 -100.28, 24.84 287.71, 79.66 -57.6, -41.09 in-in in 8.185 Saltbr-in 2.946 HRD-in -71.69, -47.92 71.62, 0.22 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.88, 155.75 APE9-dihe-in -122.51, 89.95 APE8-dihe-in -81.37, 70.05 APE8-rot-na 30.61 APE67-dihe-in -66.22, -12.9 -45.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 7.661 APE10-dist-na 8.489 APE9-dist-na 7.717 P572S,P573G None None XRAY 1.737 0.231 0.256 B 297 276 9 0 0 1 [[472, 750]] 1.0 8udu Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus DFGAsp-rot-out -108.64, 157.87 56.15, 40.62 295.75, -51.28 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-na 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus DFGAsp-rot-out -109.74, 157.08 55.91, 40.67 296.56, -52.6 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaaa APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-na 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.6e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR HCK HCK_HUMAN 2C0IA P08631 81 526 526.0 L1G:61506 Type1.5_Front Inactive DFGin 6.769 17.744 BLBtrans DFGAsp-rot-out -115.37, 154.0 70.82, 18.12 277.5, -11.55 -65.91, 121.57 184.38, 41.99 105.96, -38.14 out-out out 13.402 Saltbr-out 13.311 HRD-in -75.63, -56.77 92.51, -29.31 out-out-none SNCoon out-none ActLoopNT-out 6.493 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.77 APE8-rot-na 14.74 APE67-dihe-in -66.54, -21.29 -71.46, -21.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.3 0.224 0.274 A 454 433 13 0 0 13 [[262, 513]] 1.0 2c0i Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0OA P08631 81 526 526.0 L2G:61506 Type1.5_Front Inactive DFGin 6.623 17.558 BLBtrans DFGAsp-rot-out -102.76, 170.81 68.33, 6.06 279.79, -6.51 -62.19, 117.6 178.08, 53.25 105.15, -37.25 out-out out 13.425 Saltbr-out 14.041 HRD-in -86.82, -49.88 88.79, -24.67 out-out-none SNCoon out-none ActLoopNT-out 6.543 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.2 APE8-rot-na 27.76 APE67-dihe-in -65.03, -25.33 -76.85, -18.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.85 0.204 0.273 A 454 433 13 0 0 13 [[262, 513]] 1.0 2c0o Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TA P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.584 17.846 BLBtrans DFGAsp-rot-out -103.62, 161.87 63.4, 18.68 289.46, -18.94 -68.73, 122.03 173.01, 50.25 109.42, -49.86 out-out out 13.293 Saltbr-out 13.453 HRD-in -82.0, -51.15 69.41, -3.28 out-out-none SNCoon out-none ActLoopNT-out 6.066 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 73.05 APE8-rot-na 27.06 APE67-dihe-in -75.03, -15.66 -73.32, -16.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 A 454 427 13 0 0 13 [[262, 513]] 1.0 2c0t Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 2C0TB P08631 81 526 526.0 L3G:61506 Type1.5_Front Inactive DFGin 6.709 17.866 BLBtrans DFGAsp-rot-out -104.05, 163.35 58.02, 34.32 293.3, -8.27 -79.78, 115.19 166.03, 51.93 89.06, 7.58 out-out out 14.206 Saltbr-out 14.127 HRD-in -92.96, -48.52 72.3, -13.86 out-out-none SNCoon out-none ActLoopNT-out 7.074 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 168.21 APE8-rot-na 23.75 APE67-dihe-in -65.46, -15.21 -125.7, -33.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.15 0.197 0.253 B 454 429 13 0 0 13 [[262, 513]] 1.0 2c0t Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZA P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.653 17.605 BLBtrans DFGAsp-rot-out -107.49, 162.36 65.41, 22.25 268.54, -33.15 -66.55, 118.82 172.12, 49.89 104.47, -23.12 out-out out 13.704 Saltbr-out 14.161 HRD-in -91.87, -51.27 85.65, -25.59 out-out-none SNCoon out-none ActLoopNT-out 6.947 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 57.56 APE8-rot-na 29.34 APE67-dihe-in -64.65, 2.38 -52.77, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 A 454 429 13 0 0 13 [[262, 513]] 1.0 3vrz Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VRZB P08631 81 526 526.0 VRZ:60603 Type1.5_Front Inactive DFGin 6.496 17.504 BLBtrans DFGAsp-rot-out -106.94, 168.11 63.9, 13.84 252.07, 14.02 -60.21, 119.93 180.64, 41.8 108.28, -25.57 out-out out 13.229 Saltbr-out 13.467 HRD-in -97.14, -43.33 79.11, -20.29 out-out-none SNCoon out-none ActLoopNT-out 6.263 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.9 APE8-dihe-in -90.85, 64.85 APE8-rot-na 34.91 APE67-dihe-in -66.47, -19.82 -63.44, -23.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.492 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.218 0.267 0.267 B 454 430 12 0 0 12 [[262, 513]] 1.0 3vrz Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 3F5PA P08069 981 1286 1367.0 741:60001 Type1.5_Front Inactive DFGin 6.61 16.748 ABAminus DFGAsp-rot-in -138.06, -25.59 -129.58, 107.73 181.38, -16.46 -116.06, 43.16 310.54, 93.03 -78.83, -11.08 out-out out 11.275 Saltbr-out 6.906 HRD-in -67.38, -43.83 73.05, -28.09 out-in-out SNCoio in-out ActLoopNT-in 2.971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.2, 9.43 APE9-dihe-in -62.84, 138.01 APE8-dihe-in -63.08, 132.26 APE8-rot-na 338.19 APE67-dihe-in -72.6, -14.18 -69.93, -24.15 APE12-dist-na 13.896 APE11-dist-na 10.264 APE10-dist-na 9.82 APE9-dist-na 6.264 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 A 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PB P08069 981 1286 1367.0 741:60002 Type1.5_Front Inactive DFGin 6.74 16.774 ABAminus DFGAsp-rot-in -147.75, -6.76 -126.37, 106.72 190.37, -15.78 -113.94, 18.15 303.38, 100.96 -63.88, -6.59 out-out out 11.005 Saltbr-out 7.016 HRD-in -75.04, -39.09 66.41, -28.14 out-in-out SNCoio in-out ActLoopNT-in 2.98 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.44, 30.24 APE9-dihe-in -71.55, 137.53 APE8-dihe-in -59.54, 131.44 APE8-rot-na 338.8 APE67-dihe-in -62.32, -22.71 -80.06, -23.54 APE12-dist-na 13.869 APE11-dist-na 10.125 APE10-dist-na 10.151 APE9-dist-na 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 B 308 300 6 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PC P08069 981 1286 1367.0 741:60003 Type1.5_Front Inactive DFGin 6.476 16.508 ABAminus DFGAsp-rot-in -131.28, -29.71 -123.17, 122.2 184.37, -8.23 -124.32, 31.59 310.58, 97.96 -71.28, -4.47 out-out out 11.326 Saltbr-out 7.151 HRD-in -67.89, -44.01 69.59, -29.8 out-in-out SNCoio in-out ActLoopNT-in 2.929 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -113.67, 21.52 APE9-dihe-in -66.68, 135.08 APE8-dihe-in -55.37, 125.9 APE8-rot-na 335.16 APE67-dihe-in -63.64, -20.63 -71.03, -23.62 APE12-dist-na 13.947 APE11-dist-na 10.314 APE10-dist-na 10.017 APE9-dist-na 6.347 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 C 308 303 3 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PD P08069 981 1286 1367.0 741:60004 Type1.5_Front Inactive DFGin 6.691 16.948 ABAminus DFGAsp-rot-in -123.55, -41.41 -120.41, 118.96 171.46, -26.66 -120.72, 27.37 304.28, 99.29 -67.93, -13.37 out-out out 11.466 Saltbr-out 7.444 HRD-in -72.44, -43.38 70.69, -28.87 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.64, 11.87 APE9-dihe-in -60.75, 136.9 APE8-dihe-in -61.78, 130.42 APE8-rot-na 20.36 APE67-dihe-in -67.44, -13.84 -72.23, -24.66 APE12-dist-na 13.872 APE11-dist-na 10.33 APE10-dist-na 10.049 APE9-dist-na 6.368 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 D 308 299 7 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PE P08069 981 1285 1367.0 741:60005 Type1.5_Front Inactive DFGin 6.694 16.82 ABAminus DFGAsp-rot-in -135.52, -29.09 -118.77, 122.15 185.37, -4.42 -123.6, 9.7 296.44, 108.3 -57.57, -18.08 out-out out 11.069 Saltbr-out 7.271 HRD-in -68.6, -42.13 69.21, -24.51 out-in-out SNCoio in-out ActLoopNT-in 2.855 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -119.4, 7.14 APE9-dihe-in -54.67, 137.93 APE8-dihe-in -65.35, 131.07 APE8-rot-na 341.16 APE67-dihe-in -64.5, -10.68 -68.92, -32.58 APE12-dist-na 14.021 APE11-dist-na 10.452 APE10-dist-na 10.148 APE9-dist-na 6.28 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 E 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PF P08069 981 1285 1367.0 741:60006 Type1.5_Front Inactive DFGin 6.483 16.672 ABAminus DFGAsp-rot-in -133.64, -29.08 -124.95, 116.76 179.94, -13.2 -119.73, 22.12 307.37, 101.54 -62.11, -21.12 out-out out 11.456 Saltbr-out 7.439 HRD-in -66.51, -41.75 69.88, -16.79 out-in-out SNCoio in-out ActLoopNT-in 2.973 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.91, 14.58 APE9-dihe-in -64.37, 136.64 APE8-dihe-in -51.49, 126.07 APE8-rot-na 332.53 APE67-dihe-in -71.57, -11.29 -75.66, -21.34 APE12-dist-na 14.067 APE11-dist-na 10.393 APE10-dist-na 10.014 APE9-dist-na 6.14 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 F 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PG P08069 981 1285 1367.0 741:60007 Type1.5_Front Inactive DFGin 6.83 16.816 ABAminus DFGAsp-rot-in -142.79, -22.58 -124.37, 117.71 176.98, -11.22 -119.99, 31.05 299.76, 104.87 -73.83, -11.77 out-out out 11.313 Saltbr-out 7.0 HRD-in -78.88, -44.79 72.24, -24.62 out-in-out SNCoio in-out ActLoopNT-in 2.969 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -107.94, 24.79 APE9-dihe-in -73.02, 139.57 APE8-dihe-in -63.97, 132.91 APE8-rot-na 337.39 APE67-dihe-in -71.97, -5.77 -75.29, -20.42 APE12-dist-na 14.012 APE11-dist-na 10.239 APE10-dist-na 9.892 APE9-dist-na 6.221 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 G 308 301 4 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PH P08069 981 1286 1367.0 741:60008 Type1.5_Front Inactive DFGin 6.629 16.429 ABAminus DFGAsp-rot-in -135.18, -37.61 -123.09, 112.94 185.48, -1.81 -114.78, 16.78 310.03, 93.21 -57.54, -9.93 out-out out 11.26 Saltbr-out 7.542 HRD-in -79.51, -41.44 75.33, -29.75 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -108.47, 10.93 APE9-dihe-in -59.95, 134.42 APE8-dihe-in -57.02, 119.96 APE8-rot-na 332.96 APE67-dihe-in -72.4, -8.79 -61.06, -25.16 APE12-dist-na 14.198 APE11-dist-na 10.466 APE10-dist-na 10.185 APE9-dist-na 6.401 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 H 308 301 5 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PI P08069 981 1285 1367.0 741:60009 Type1.5_Front Inactive DFGin 6.637 16.461 ABAminus DFGAsp-rot-in -144.33, -12.52 -125.22, 113.79 188.79, -23.37 -116.99, 15.78 300.54, 108.07 -62.21, -14.24 out-out out 10.889 Saltbr-out 6.889 HRD-in -60.61, -42.68 67.93, -23.46 out-in-out SNCoio in-out ActLoopNT-in 2.917 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.73, 15.28 APE9-dihe-in -67.33, 139.53 APE8-dihe-in -63.65, 128.86 APE8-rot-na 345.01 APE67-dihe-in -68.57, -17.49 -69.06, -21.27 APE12-dist-na 13.914 APE11-dist-na 10.23 APE10-dist-na 9.797 APE9-dist-na 6.228 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 I 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PJ P08069 981 1285 1367.0 741:60010 Type1.5_Front Inactive DFGin 6.647 16.713 ABAminus DFGAsp-rot-in -137.35, -22.07 -131.76, 119.09 176.99, -10.12 -115.56, 22.57 300.22, 101.26 -61.94, -18.78 out-out out 10.94 Saltbr-out 6.672 HRD-in -74.88, -41.95 72.95, -30.32 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.55, 26.2 APE9-dihe-in -76.04, 131.14 APE8-dihe-in -47.14, 118.18 APE8-rot-na 11.41 APE67-dihe-in -74.24, -9.54 -60.76, -20.49 APE12-dist-na 14.276 APE11-dist-na 10.237 APE10-dist-na 10.205 APE9-dist-na 6.46 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 J 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PK P08069 981 1285 1367.0 741:60011 Type1.5_Front Inactive DFGin 6.407 16.547 ABAminus DFGAsp-rot-in -137.37, -28.84 -124.99, 120.18 174.44, 4.56 -119.7, 16.02 301.42, 102.62 -59.26, -20.51 out-out out 11.163 Saltbr-out 6.697 HRD-in -69.13, -50.03 76.13, -25.52 out-in-out SNCoio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -116.66, 8.96 APE9-dihe-in -58.52, 142.15 APE8-dihe-in -59.15, 129.43 APE8-rot-na 338.61 APE67-dihe-in -60.69, -25.24 -69.7, -27.83 APE12-dist-na 14.114 APE11-dist-na 10.152 APE10-dist-na 9.947 APE9-dist-na 6.405 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 K 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PL P08069 981 1285 1367.0 741:60013 Type1.5_Front Inactive DFGin 6.56 16.394 ABAminus DFGAsp-rot-in -130.09, -30.53 -132.5, 115.28 164.26, 2.13 -114.91, 24.81 310.05, 96.63 -62.07, -19.46 out-out out 11.029 Saltbr-out 6.97 HRD-in -66.51, -50.25 76.73, -28.84 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -112.68, 19.75 APE9-dihe-in -67.29, 128.45 APE8-dihe-in -49.93, 126.32 APE8-rot-na 13.1 APE67-dihe-in -68.28, -21.28 -70.5, -21.67 APE12-dist-na 14.19 APE11-dist-na 10.315 APE10-dist-na 10.171 APE9-dist-na 6.356 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 L 308 295 10 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PM P08069 981 1285 1367.0 741:60012 Type1.5_Front Inactive DFGin 6.771 16.613 ABAminus DFGAsp-rot-in -128.57, -42.47 -122.66, 116.51 178.99, -22.16 -120.09, 38.47 314.34, 94.44 -73.17, -23.07 out-out out 11.214 Saltbr-out 7.332 HRD-in -78.25, -49.69 75.71, -26.22 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -117.51, 9.39 APE9-dihe-in -60.52, 138.49 APE8-dihe-in -61.63, 125.4 APE8-rot-na 341.15 APE67-dihe-in -68.1, -5.47 -67.37, -25.72 APE12-dist-na 13.872 APE11-dist-na 10.161 APE10-dist-na 9.914 APE9-dist-na 6.394 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 M 308 297 8 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PR P08069 981 1285 1367.0 741:60014 Type1.5_Front Inactive DFGin 6.538 16.629 ABAminus DFGAsp-rot-in -139.04, -20.87 -125.55, 103.39 185.52, 0.6 -109.5, 25.04 311.13, 96.42 -58.59, -20.19 out-out out 11.106 Saltbr-out 7.253 HRD-in -61.08, -46.93 71.37, -30.05 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -121.06, 13.96 APE9-dihe-in -63.18, 134.5 APE8-dihe-in -57.6, 125.54 APE8-rot-na 338.75 APE67-dihe-in -68.47, -18.65 -66.66, -22.95 APE12-dist-na 14.134 APE11-dist-na 10.186 APE10-dist-na 10.002 APE9-dist-na 6.439 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 R 308 296 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PS P08069 981 1286 1367.0 741:60015 Type1.5_Front Inactive DFGin 6.621 16.362 ABAminus DFGAsp-rot-in -137.74, -25.34 -122.78, 115.95 189.34, 4.69 -115.05, 8.88 304.38, 111.51 -47.71, -27.84 out-out out 11.103 Saltbr-out 6.886 HRD-in -69.09, -43.99 64.64, -15.6 out-in-out SNCoio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -120.58, 17.02 APE9-dihe-in -62.27, 136.85 APE8-dihe-in -61.63, 122.69 APE8-rot-na 21.86 APE67-dihe-in -66.47, -21.61 -67.46, -19.45 APE12-dist-na 13.986 APE11-dist-na 10.237 APE10-dist-na 10.157 APE9-dist-na 6.245 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 S 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3F5PT P08069 981 1286 1367.0 741:60016 Type1.5_Front Inactive DFGin 6.52 16.375 ABAminus DFGAsp-rot-in -141.26, -19.49 -137.77, 101.2 180.1, -14.6 -103.13, 11.95 304.34, 96.76 -50.98, -21.44 out-out out 10.787 Saltbr-out 6.707 HRD-in -77.18, -39.29 69.12, -25.78 out-in-out SNCoio in-out ActLoopNT-in 2.859 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -114.42, 13.71 APE9-dihe-in -68.71, 130.72 APE8-dihe-in -54.94, 124.12 APE8-rot-na 340.88 APE67-dihe-in -66.19, -17.17 -61.43, -26.74 APE12-dist-na 13.846 APE11-dist-na 10.239 APE10-dist-na 9.88 APE9-dist-na 6.273 None PTR1161,PTR1165,PTR1166 PTR1161,PTR1165,PTR1166 XRAY 2.9 0.212 0.258 T 308 297 9 0 0 0 [[999, 1268]] 1.0 3f5p Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3D94A P08069 986 1285 1367.0 D94:60001 Type1.5_Front Inactive DFGin 5.753 12.09 None DFGAsp-rot-in -113.77, -141.33 -41.63, 115.12 193.94, 11.59 -104.14, 0.25 54.89, 83.46 -78.61, -17.4 out-out out 11.035 Saltbr-out 11.282 HRD-in -72.35, -49.36 78.31, -12.49 out-out-in SNCooi out-in ActLoopNT-out 9.257 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -76.21, 135.68 APE9-dihe-in -120.98, 133.2 APE8-dihe-in -80.59, 66.97 APE8-rot-na 24.88 APE67-dihe-in -76.95, -9.87 -55.9, -29.5 APE12-dist-na 12.646 APE11-dist-na 8.596 APE10-dist-na 6.456 APE9-dist-na 7.111 None None MHO1142 XRAY 2.3 0.2 0.236 A 301 289 11 0 0 0 [[999, 1268]] 1.0 3d94 Homo sapiens TYR_IGF1R_HUMAN TYR 3.3e-95 324.3 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIAAA P08069 986 1286 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.183 12.51 None DFGAsp-rot-in -115.76, -140.08 -56.69, 128.49 194.85, -1.13 -118.25, -19.27 59.93, 80.29 -40.9, -38.76 out-out out 10.581 Saltbr-out 8.136 HRD-in -71.36, -56.99 87.46, -13.56 out-out-none SNCoon out-none ActLoopNT-out 8.922 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 111.18 APE9-dihe-in -126.65, 126.64 APE8-dihe-in -81.12, 76.62 APE8-rot-na 35.9 APE67-dihe-in -71.26, -20.53 -54.98, -37.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.172 APE9-dist-na 7.073 None None None XRAY 3.06 0.193 0.235 AAA 321 288 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIBBB P08069 986 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.22 12.447 None DFGAsp-rot-in -115.29, -140.05 -57.59, 130.35 191.36, 3.91 -119.47, -19.04 57.6, 81.65 -39.33, -40.51 out-out out 10.581 Saltbr-out 8.138 HRD-in -71.54, -57.15 87.92, -15.23 out-out-none SNCoon out-none ActLoopNT-out 8.993 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.31 APE9-dihe-in -126.67, 128.52 APE8-dihe-in -80.09, 76.32 APE8-rot-na 35.62 APE67-dihe-in -70.72, -20.09 -56.2, -36.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.11 APE9-dist-na 7.068 None None None XRAY 3.06 0.193 0.235 BBB 321 287 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYICCC P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.166 12.505 None DFGAsp-rot-in -114.85, -140.89 -57.29, 129.65 193.0, 0.84 -118.38, -19.22 58.71, 80.33 -40.35, -39.19 out-out out 10.547 Saltbr-out 8.078 HRD-in -70.97, -56.86 87.86, -15.93 out-out-in SNCooi out-in ActLoopNT-out 8.949 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -146.69, 116.05 APE9-dihe-in -129.59, 126.27 APE8-dihe-in -80.63, 76.08 APE8-rot-na 36.39 APE67-dihe-in -71.13, -19.68 -54.93, -37.06 APE12-dist-na 999.0 APE11-dist-na 9.653 APE10-dist-na 6.184 APE9-dist-na 7.131 None None None XRAY 3.06 0.193 0.235 CCC 321 286 13 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIDDD P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.219 12.459 None DFGAsp-rot-in -115.04, -139.19 -57.22, 129.11 193.91, 0.08 -118.66, -19.63 58.67, 81.12 -40.31, -39.48 out-out out 10.605 Saltbr-out 8.095 HRD-in -71.24, -57.12 86.84, -13.26 out-out-in SNCooi out-in ActLoopNT-out 8.935 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.29, 122.24 APE9-dihe-in -125.14, 125.87 APE8-dihe-in -79.9, 75.59 APE8-rot-na 36.0 APE67-dihe-in -70.95, -19.69 -56.73, -36.41 APE12-dist-na 999.0 APE11-dist-na 9.553 APE10-dist-na 5.986 APE9-dist-na 7.125 None None None XRAY 3.06 0.193 0.235 DDD 321 287 12 0 0 4 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIEEE P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.27 12.44 None DFGAsp-rot-in -115.61, -138.87 -56.86, 128.87 193.98, 0.75 -118.49, -19.41 58.83, 81.0 -40.15, -38.87 out-out out 10.516 Saltbr-out 8.092 HRD-in -71.39, -56.94 87.82, -14.48 out-out-none SNCoon out-none ActLoopNT-out 8.951 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 116.42 APE9-dihe-in -125.67, 127.35 APE8-dihe-in -81.15, 76.83 APE8-rot-na 35.52 APE67-dihe-in -70.81, -19.39 -56.95, -36.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.155 APE9-dist-na 7.113 None None None XRAY 3.06 0.193 0.235 EEE 321 285 14 0 0 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIFFF P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.31 12.506 None DFGAsp-rot-in -114.84, -139.12 -57.32, 129.09 194.57, -0.49 -119.24, -19.1 58.43, 80.95 -39.6, -40.34 out-out out 10.562 Saltbr-out 8.089 HRD-in -71.51, -57.69 87.61, -14.16 out-out-in SNCooi out-in ActLoopNT-out 8.913 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -146.97, 119.39 APE9-dihe-in -127.92, 126.81 APE8-dihe-in -81.17, 76.54 APE8-rot-na 34.85 APE67-dihe-in -70.74, -20.02 -56.2, -36.99 APE12-dist-na 14.267 APE11-dist-na 9.704 APE10-dist-na 6.176 APE9-dist-na 7.071 None None None XRAY 3.06 0.193 0.235 FFF 321 287 12 0 0 3 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIGGG P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.215 12.411 None DFGAsp-rot-in -115.39, -138.9 -56.85, 128.81 194.12, 1.71 -118.89, -19.11 58.65, 81.01 -40.57, -39.34 out-out out 10.582 Saltbr-out 8.151 HRD-in -71.45, -56.87 87.79, -13.89 out-out-none SNCoon out-none ActLoopNT-out 8.956 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 115.56 APE9-dihe-in -139.88, 129.5 APE8-dihe-in -81.92, 78.52 APE8-rot-na 36.73 APE67-dihe-in -71.48, -19.02 -54.63, -36.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.313 APE9-dist-na 6.925 None None None XRAY 3.06 0.193 0.235 GGG 321 284 15 0 0 6 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYIHHH P08069 987 1285 1367.0 IER:3000 Type1.5_Front Inactive DFGin 6.201 12.494 None DFGAsp-rot-in -116.04, -140.1 -57.52, 129.83 192.69, 1.38 -118.81, -19.1 57.82, 80.84 -40.32, -39.43 out-out out 10.616 Saltbr-out 8.121 HRD-in -71.69, -57.04 87.53, -14.25 out-out-none SNCoon out-none ActLoopNT-out 8.959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.91 APE9-dihe-in -126.66, 127.03 APE8-dihe-in -79.81, 75.92 APE8-rot-na 35.31 APE67-dihe-in -70.25, -19.75 -57.25, -36.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 6.154 APE9-dist-na 7.165 None None None XRAY 3.06 0.193 0.235 HHH 321 285 14 0 0 5 [[999, 1268]] 1.0 8pyi Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNA P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.523 11.883 None DFGAsp-rot-in -122.71, -134.04 -48.48, 117.08 193.21, -3.88 -112.65, 5.39 56.52, 89.56 -80.2, -12.63 out-out out 10.105 Saltbr-out 7.07 HRD-in -68.72, -44.68 74.42, -15.27 out-out-in SNCooi out-in ActLoopNT-out 9.082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.2, 129.26 APE9-dihe-in -125.1, 113.12 APE8-dihe-in -76.3, 72.6 APE8-rot-na 31.29 APE67-dihe-in -71.82, -14.27 -59.77, -33.09 APE12-dist-na 12.78 APE11-dist-na 9.341 APE10-dist-na 6.003 APE9-dist-na 7.412 E1097A,E1099A None None XRAY 2.2 0.195 0.218 A 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNB P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.668 11.698 None DFGAsp-rot-in -120.23, -145.7 -34.99, 114.07 201.91, -7.17 -109.86, 7.02 53.42, 94.67 -86.81, -17.85 out-out out 10.23 Saltbr-out 7.469 HRD-in -74.79, -42.86 77.21, -19.92 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.8, 127.36 APE9-dihe-in -126.61, 120.91 APE8-dihe-in -82.51, 72.5 APE8-rot-na 31.18 APE67-dihe-in -70.34, -12.61 -56.19, -36.04 APE12-dist-na 12.71 APE11-dist-na 9.436 APE10-dist-na 6.009 APE9-dist-na 7.413 E1097A,E1099A None None XRAY 2.2 0.195 0.218 B 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNC P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.504 11.893 None DFGAsp-rot-in -117.5, -144.25 -35.28, 118.67 193.73, 0.69 -116.54, 5.75 57.58, 87.45 -83.77, -13.7 out-out out 10.205 Saltbr-out 6.568 HRD-in -68.11, -52.05 81.72, -11.87 out-out-in SNCooi out-in ActLoopNT-out 8.979 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -79.64, 128.06 APE9-dihe-in -121.48, 117.98 APE8-dihe-in -78.81, 67.18 APE8-rot-na 28.39 APE67-dihe-in -73.45, -14.3 -52.08, -33.81 APE12-dist-na 13.032 APE11-dist-na 9.428 APE10-dist-na 6.062 APE9-dist-na 7.275 E1097A,E1099A None None XRAY 2.2 0.195 0.218 C 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZND P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.586 11.812 None DFGAsp-rot-in -120.23, -138.34 -41.88, 115.18 198.43, -7.81 -111.54, 6.87 52.55, 90.98 -80.5, -21.29 out-out out 10.156 Saltbr-out 7.057 HRD-in -75.17, -45.42 77.74, -21.01 out-out-in SNCooi out-in ActLoopNT-out 9.098 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.35, 128.86 APE9-dihe-in -120.46, 118.5 APE8-dihe-in -79.97, 71.37 APE8-rot-na 32.37 APE67-dihe-in -73.39, -13.02 -52.14, -35.35 APE12-dist-na 13.179 APE11-dist-na 9.253 APE10-dist-na 6.021 APE9-dist-na 7.453 E1097A,E1099A None None XRAY 2.2 0.195 0.218 D 304 304 0 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNE P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.534 11.884 None DFGAsp-rot-in -122.97, -133.9 -50.03, 120.11 190.59, -4.54 -115.89, 7.06 56.85, 84.61 -81.92, -13.97 out-out out 10.09 Saltbr-out 7.001 HRD-in -71.62, -46.82 77.23, -15.08 out-out-in SNCooi out-in ActLoopNT-out 9.076 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.35, 128.61 APE9-dihe-in -123.88, 113.86 APE8-dihe-in -76.92, 69.0 APE8-rot-na 31.9 APE67-dihe-in -73.44, -14.93 -54.7, -32.97 APE12-dist-na 12.756 APE11-dist-na 9.32 APE10-dist-na 6.009 APE9-dist-na 7.417 E1097A,E1099A None None XRAY 2.2 0.195 0.218 E 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNF P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.669 11.686 None DFGAsp-rot-in -119.91, -143.87 -36.57, 117.22 200.05, -12.35 -111.83, 7.84 53.92, 93.37 -86.48, -19.66 out-out out 10.245 Saltbr-out 7.495 HRD-in -71.54, -45.74 77.92, -19.28 out-out-in SNCooi out-in ActLoopNT-out 8.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.77, 125.58 APE9-dihe-in -123.67, 120.15 APE8-dihe-in -81.16, 71.31 APE8-rot-na 31.34 APE67-dihe-in -70.78, -14.02 -54.99, -34.82 APE12-dist-na 12.696 APE11-dist-na 9.431 APE10-dist-na 6.025 APE9-dist-na 7.415 E1097A,E1099A None None XRAY 2.2 0.195 0.218 F 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNG P08069 983 1286 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.495 11.888 None DFGAsp-rot-in -115.22, -143.92 -37.17, 121.14 194.75, -1.88 -119.03, 5.44 57.57, 87.05 -84.31, -13.87 out-out out 10.212 Saltbr-out 6.568 HRD-in -69.56, -54.08 84.44, -12.44 out-out-in SNCooi out-in ActLoopNT-out 8.999 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -81.44, 128.11 APE9-dihe-in -122.01, 115.9 APE8-dihe-in -78.8, 69.19 APE8-rot-na 29.58 APE67-dihe-in -71.28, -16.87 -55.78, -34.47 APE12-dist-na 13.018 APE11-dist-na 9.418 APE10-dist-na 6.068 APE9-dist-na 7.312 E1097A,E1099A None None XRAY 2.2 0.195 0.218 G 304 296 8 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 5HZNH P08069 983 1285 1367.0 66A:61301 Type1.5_Front Inactive DFGin 5.564 11.84 None DFGAsp-rot-in -117.51, -139.77 -40.96, 115.52 196.3, -3.46 -113.35, 4.84 52.59, 91.03 -79.05, -20.18 out-out out 10.169 Saltbr-out 7.132 HRD-in -75.23, -47.04 79.69, -19.55 out-out-in SNCooi out-in ActLoopNT-out 9.113 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -78.78, 128.57 APE9-dihe-in -119.04, 118.91 APE8-dihe-in -80.75, 73.24 APE8-rot-na 32.94 APE67-dihe-in -74.0, -12.28 -56.22, -33.69 APE12-dist-na 13.184 APE11-dist-na 9.261 APE10-dist-na 6.031 APE9-dist-na 7.449 E1097A,E1099A None None XRAY 2.2 0.195 0.218 H 304 303 0 0 0 0 [[999, 1268]] 1.0 5hzn Homo sapiens TYR_IGF1R_HUMAN TYR 2e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 5HHWA P06213 1005 1310 1382.0 60O:1401 Type1.5_Front Inactive DFGin 6.547 15.218 None DFGAsp-rot-in -93.96, -126.86 -75.33, 119.05 185.67, 17.74 -115.08, 17.9 55.03, 94.29 -68.54, 168.98 in-out in 9.644 Saltbr-out 6.203 HRD-in -63.14, -55.1 75.15, -13.24 out-out-in SNCooi out-in ActLoopNT-out 12.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -83.8, 124.07 APE9-dihe-in -122.61, 132.0 APE8-dihe-in -80.76, 65.66 APE8-rot-na 27.91 APE67-dihe-in -68.74, -10.86 -50.91, -39.07 APE12-dist-na 13.71 APE11-dist-na 10.945 APE10-dist-na 9.756 APE9-dist-na 7.506 C1008S,D1159N None None XRAY 1.79 0.172 0.198 A 307 306 0 0 0 0 [[1023, 1292]] 1.0 5hhw Homo sapiens TYR_INSR_HUMAN TYR 5.7e-96 326.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 6PDJA P06239 225 500 509.0 ODJ:60601 Type1.5_Front Inactive DFGout 11.351 8.956 BBAminus DFGAsp-rot-in -108.06, 146.7 -118.62, 138.04 175.49, 43.58 -125.67, 34.93 300.23, 95.6 96.65, -2.92 out-none out 17.115 Saltbr-none 999.0 HRD-in -91.73, -46.03 72.74, -1.78 none-in-in SNCnii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -117.11, 126.2 APE9-dihe-in -121.94, 158.33 APE8-dihe-in -71.45, 105.31 APE8-rot-na 23.06 APE67-dihe-in -61.4, -18.91 -48.25, -48.5 APE12-dist-na 15.007 APE11-dist-na 10.591 APE10-dist-na 12.887 APE9-dist-na 6.856 None PTR394 PTR394 XRAY 1.81 0.169 0.217 A 288 271 0 0 0 0 [[245, 496]] 1.0 6pdj Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 7AAZA Q12866 574 863 999.0 R6K:901 Type1.5_Front Inactive DFGin 6.931 13.0 BLAminus DFGAsp-rot-in -138.31, -157.88 39.97, 76.8 204.07, -16.71 -86.63, 13.92 303.38, 139.91 -55.98, -23.43 out-out out 13.714 Saltbr-out 13.412 HRD-in -73.08, -57.78 72.91, 6.58 out-in-out SNCoio in-out ActLoopNT-in 2.755 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -69.02, -26.36 APE9-dihe-in -66.36, 123.32 APE8-dihe-in -78.41, 127.1 APE8-rot-na 30.52 APE67-dihe-in -75.24, 0.32 -53.59, -39.62 APE12-dist-na 9.191 APE11-dist-na 11.609 APE10-dist-na 7.365 APE9-dist-na 4.907 None None None XRAY 1.855 0.189 0.219 A 296 290 0 0 0 0 [[587, 856]] 1.0 7aaz Homo sapiens TYR_MERTK_HUMAN TYR 1.2e-92 315.9 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus DFGAsp-rot-in -138.66, -158.87 44.96, 74.5 205.27, 0.86 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-na 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHJA Q12866 578 862 999.0 A1APG:60901 Type1.5_Front Inactive DFGin 7.068 13.244 BLAminus DFGAsp-rot-out -146.72, -174.1 64.74, 69.57 296.14, 87.8 -92.99, 18.47 306.82, 135.89 -58.57, -33.38 out-out out 13.147 Saltbr-out 13.083 HRD-in -74.38, -50.97 66.43, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.931 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -101.13, 12.6 APE9-dihe-in -72.99, 145.36 APE8-dihe-in -59.15, 119.95 APE8-rot-na 335.8 APE67-dihe-in -75.1, -1.94 -63.08, -26.94 APE12-dist-na 7.006 APE11-dist-na 11.862 APE10-dist-na 11.009 APE9-dist-na 6.692 None None None XRAY 2.294 0.22 0.252 A 323 279 6 0 0 0 [[587, 856]] 1.0 9bhj Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9BHKA Q12866 578 862 999.0 A1APH:60901 Type1.5_Front Inactive DFGin 7.438 13.112 BLAminus DFGAsp-rot-out -146.17, -169.74 58.59, 57.61 300.0, 89.03 -88.08, 14.92 314.86, 133.55 -56.57, -30.36 out-out out 13.408 Saltbr-out 13.148 HRD-in -71.96, -51.79 69.44, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -99.49, 5.66 APE9-dihe-in -63.51, 142.65 APE8-dihe-in -57.87, 119.03 APE8-rot-na 336.99 APE67-dihe-in -73.75, -3.45 -57.71, -31.48 APE12-dist-na 7.129 APE11-dist-na 11.95 APE10-dist-na 11.013 APE9-dist-na 6.435 None None None XRAY 2.106 0.208 0.229 A 323 273 12 0 0 0 [[587, 856]] 1.0 9bhk Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW2A Q12866 571 862 999.0 S4W:60901 Type1.5_Front Inactive DFGin 6.721 12.964 BLBminus DFGAsp-rot-in -150.9, -171.53 41.59, 54.7 237.99, -37.37 -57.18, 136.95 317.76, 109.5 -43.48, 130.9 out-out out 12.917 Saltbr-out 13.1 HRD-in -73.03, -51.56 71.01, 1.22 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.98 APE8-rot-na 17.36 APE67-dihe-in -72.89, 2.66 -33.8, -45.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 2.1 0.208 0.238 A 298 267 25 0 0 18 [[587, 856]] 1.0 7aw2 Homo sapiens TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLSA Q12866 571 862 999.0 VJZ:60901 Type1.5_Front Inactive DFGin 6.656 13.567 BLBminus DFGAsp-rot-out -153.83, -175.53 51.86, 59.49 254.96, -38.28 -72.66, 142.42 308.34, 110.17 -75.07, 999.0 out-out out 13.556 Saltbr-out 13.877 HRD-in -70.87, -52.35 83.16, -32.56 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.15 APE8-rot-na 35.66 APE67-dihe-in -76.51, -1.1 -58.07, -40.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 1.89 0.222 0.282 A 298 269 23 0 0 19 [[587, 856]] 1.0 7ols Homo sapiens TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLVA Q12866 571 862 999.0 VK2:60901 Type1.5_Front Inactive DFGin 6.528 13.64 BLBminus DFGAsp-rot-out -149.58, -174.75 55.04, 54.02 255.64, -42.84 -65.24, 140.11 308.45, 116.95 -72.6, 999.0 out-out out 13.503 Saltbr-out 14.112 HRD-in -71.43, -46.21 70.23, 5.98 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.84 APE8-rot-na 31.04 APE67-dihe-in -72.99, -5.09 -55.61, -36.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 2.13 0.21 0.247 A 298 269 23 0 0 19 [[587, 856]] 1.0 7olv Homo sapiens TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7OLXA Q12866 571 862 999.0 VK5:60901 Type1.5_Front Inactive DFGin 6.209 13.727 BLBminus DFGAsp-rot-in -149.38, -179.13 56.05, 51.35 227.01, -28.44 -58.87, 139.21 312.09, 118.2 -79.48, 999.0 out-out out 13.764 Saltbr-out 12.352 HRD-in -72.38, -52.17 78.72, -5.83 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 42.77 APE8-rot-na 35.47 APE67-dihe-in -74.39, -3.51 -55.36, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 K591R,K693R,K702R,K856R None None XRAY 1.98 0.205 0.251 A 298 271 21 0 0 19 [[587, 856]] 1.0 7olx Homo sapiens TYR_MERTK_HUMAN TYR 2.4e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AVXA Q12866 577 862 999.0 S4K:901 Type1.5_Front Inactive DFGin 6.212 14.187 BLBplus DFGAsp-rot-out -139.94, 176.96 57.63, 33.7 284.36, -23.5 -91.93, 149.58 50.89, 81.01 -76.42, 165.87 out-out out 12.696 Saltbr-out 9.191 HRD-in -70.33, -65.18 70.62, 12.45 out-out-out SNCooo out-out ActLoopNT-out 5.197 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -81.78, -23.56 APE9-dihe-in -75.41, 164.94 APE8-dihe-in -70.62, 164.17 APE8-rot-na 350.35 APE67-dihe-in -69.09, -9.08 -44.67, -43.43 APE12-dist-na 13.398 APE11-dist-na 14.161 APE10-dist-na 11.783 APE9-dist-na 4.623 None None None XRAY 2.44 0.216 0.259 A 313 276 10 0 0 5 [[587, 856]] 1.0 7avx Homo sapiens TYR_MERTK_HUMAN TYR 1.5e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZA Q12866 577 864 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 16.995 9.166 None DFGAsp-rot-in -144.96, 178.8 -147.12, 97.05 189.15, 3.97 -55.74, 999.0 272.88, 54.11 999.0, 999.0 out-none out 12.645 Saltbr-none 999.0 HRD-in -83.04, -57.33 76.85, -1.67 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 22.11 APE8-rot-na 9.43 APE67-dihe-in -73.23, -7.29 -55.21, -31.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.6 0.224 0.267 A 294 263 25 0 0 20 [[587, 856]] 1.0 9krz Homo sapiens TYR_MERTK_HUMAN TYR 1.2e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZB Q12866 575 863 999.0 A1L6K:901 Type1.5_Front Inactive DFGout 17.116 9.26 None DFGAsp-rot-in -136.76, -173.26 -147.11, 97.01 225.55, -15.88 -63.71, 999.0 262.09, 109.75 999.0, 999.0 out-none out 12.404 Saltbr-none 999.0 HRD-in -59.48, -61.4 74.72, -1.69 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.37 APE8-rot-na 32.13 APE67-dihe-in -79.29, -5.37 -59.11, -19.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.6 0.224 0.267 B 294 260 29 0 0 20 [[587, 856]] 1.0 9krz Homo sapiens TYR_MERTK_HUMAN TYR 1.2e-92 316.0 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3U6HA P08581 1051 1351 1390.0 03X:1 Type1.5_Front Inactive DFGin 5.5 14.419 BLBplus DFGAsp-rot-out -145.15, 179.51 61.38, 23.56 257.09, 20.81 -82.38, 149.62 53.62, 89.86 90.75, 999.0 out-out out 12.113 Saltbr-out 7.679 HRD-in -72.28, -53.74 82.85, -16.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 50.02 APE8-rot-na 30.69 APE67-dihe-in -72.37, 0.17 -64.56, -34.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.0 0.221 0.274 A 309 280 21 0 0 21 [[1078, 1339]] 1.0 3u6h Homo sapiens TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3U6IA P08581 1051 1351 1390.0 044:1 Type1.5_Front Inactive DFGin 5.277 14.587 BLBplus DFGAsp-rot-out -134.83, 174.49 60.14, 23.77 274.48, -6.43 -73.51, 140.85 47.46, 91.22 78.44, 999.0 out-out out 12.048 Saltbr-out 8.482 HRD-in -67.0, -53.9 81.23, -23.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.68 APE8-dihe-in -90.4, 68.47 APE8-rot-na 28.01 APE67-dihe-in -76.04, -5.5 -62.36, -28.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.691 None None None XRAY 2.1 0.208 0.257 A 309 281 20 0 0 20 [[1078, 1339]] 1.0 3u6i Homo sapiens TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKA P08581 1054 1351 1390.0 MT4:1 Type1.5_Front Inactive DFGin 5.064 14.093 None DFGAsp-rot-in -134.75, -178.01 61.2, 27.83 218.56, 7.55 -81.51, 999.0 42.72, 82.19 999.0, 999.0 out-out out 12.813 Saltbr-out 7.941 HRD-in -70.71, -51.36 83.62, -19.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 26.89 APE8-rot-na 29.1 APE67-dihe-in -75.12, -5.25 -59.44, -32.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.2 0.257 0.292 A 310 276 22 0 0 22 [[1078, 1339]] 1.0 3efk Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFKB P08581 1054 1351 1390.0 MT4:2 Type1.5_Front Inactive DFGin 5.171 14.171 None DFGAsp-rot-in -136.11, -178.89 60.83, 31.64 221.42, 18.82 -88.75, 999.0 42.99, 77.64 999.0, 999.0 out-out out 12.549 Saltbr-out 7.623 HRD-in -66.0, -59.6 86.12, -12.02 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 28.71 APE8-rot-na 33.98 APE67-dihe-in -75.58, -3.26 -55.05, -32.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.2 0.257 0.292 B 310 272 26 0 0 22 [[1078, 1339]] 1.0 3efk Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8ANSA P08581 1052 1346 1390.0 MDI:1402 Type1.5_Front Inactive DFGout 21.988 12.134 BBAminus DFGAsp-rot-in -113.69, 156.55 -126.28, 136.74 176.58, 50.56 -116.06, 28.6 291.38, 93.7 114.66, -11.19 out-none out 16.715 Saltbr-none 999.0 HRD-in -66.61, -50.14 72.94, -14.68 none-in-none SNCnin in-none ActLoopNT-in 2.814 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.39 APE8-dihe-in -71.16, 118.3 APE8-rot-na 25.27 APE67-dihe-in -73.48, 1.82 -58.2, -31.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.972 D1228V None None XRAY 2.01 0.232 0.277 A 296 277 18 0 0 15 [[1078, 1339]] 1.0 8ans Homo sapiens TYR_MET_HUMAN TYR 1.3e-91 312.5 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1A P08581 1053 1346 1390.0 A1AB1:1401 Type1.5_Front Inactive DFGout 14.819 9.436 BBAminus DFGAsp-rot-in -108.11, 147.26 -117.32, 132.26 185.46, 9.39 -96.14, -16.7 282.99, 100.28 74.09, 31.57 out-out out 14.533 Saltbr-out 11.844 HRD-in -73.59, -41.12 80.85, -53.9 out-out-in SNCooi out-in ActLoopNT-out 8.453 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -73.38, 142.57 APE9-dihe-in -84.31, 136.88 APE8-dihe-in -79.64, 70.29 APE8-rot-na 34.05 APE67-dihe-in -83.39, -14.09 -70.01, -29.83 APE12-dist-na 999.0 APE11-dist-na 9.426 APE10-dist-na 10.403 APE9-dist-na 8.627 None None None XRAY 3.11 0.253 0.298 A 309 284 10 0 0 7 [[1078, 1339]] 1.0 8vi1 Homo sapiens TYR_MET_HUMAN TYR 1.1e-91 313.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8VI1B P08581 1050 1345 1390.0 A1AB1:1401 Type1.5_Front Inactive DFGout 15.272 8.725 BBAminus DFGAsp-rot-in -108.54, 151.43 -123.32, 136.74 187.88, 14.93 -110.22, 12.52 275.64, 111.62 71.37, 50.45 out-out out 15.162 Saltbr-out 11.973 HRD-in -74.07, -53.17 75.69, 9.37 out-out-in SNCooi out-in ActLoopNT-out 7.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.88, 110.5 APE9-dihe-in -114.0, 153.27 APE8-dihe-in -80.31, 90.69 APE8-rot-na 32.48 APE67-dihe-in -77.51, -25.6 -72.23, -29.3 APE12-dist-na 999.0 APE11-dist-na 9.908 APE10-dist-na 10.171 APE9-dist-na 7.148 None None None XRAY 3.11 0.253 0.298 B 309 287 9 0 0 9 [[1078, 1339]] 1.0 8vi1 Homo sapiens TYR_MET_HUMAN TYR 1.1e-91 313.3 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8A P08581 1073 1345 1390.0 MDI:1405 Type1.5_Front Inactive DFGout 21.707 13.171 BBAminus DFGAsp-rot-in -94.14, 151.51 -120.93, 127.96 170.89, 55.41 -109.22, 32.25 303.58, 88.2 110.31, 1.2 out-out out 16.43 Saltbr-out 20.272 HRD-in -54.67, -51.39 71.04, -1.89 out-in-none SNCoin in-none ActLoopNT-in 2.9 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.15 APE8-rot-na 3.41 APE67-dihe-in -68.88, -23.67 -46.98, -37.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.394 0.244 0.298 A 296 244 29 0 0 10 [[1078, 1339]] 1.0 8an8 Homo sapiens TYR_MET_HUMAN TYR 6.1e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 8AN8B P08581 1058 1345 1390.0 MDI:1402 Type1.5_Front Inactive DFGout 21.849 13.195 BBAminus DFGAsp-rot-in -106.1, 150.5 -120.05, 128.27 166.7, 51.19 -113.48, 46.76 300.29, 99.64 94.11, -3.01 out-out out 16.643 Saltbr-out 17.83 HRD-in -61.73, -46.11 67.66, -9.48 out-in-none SNCoin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 100.6 APE8-dihe-in -76.12, 118.46 APE8-rot-na 29.89 APE67-dihe-in -71.35, -4.52 -60.81, -23.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.046 None None None XRAY 2.394 0.244 0.298 B 296 263 25 0 0 9 [[1078, 1339]] 1.0 8an8 Homo sapiens TYR_MET_HUMAN TYR 6.1e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJA P08581 1054 1351 1390.0 MT3:1 Type1.5_Front Inactive DFGout 14.778 8.785 None DFGAsp-rot-in -121.25, 162.39 -104.89, -29.61 213.31, -61.02 54.56, 999.0 265.44, 110.5 999.0, 999.0 out-out out 13.253 Saltbr-out 9.71 HRD-in -61.96, -46.17 77.81, -13.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.71 APE8-rot-na 30.83 APE67-dihe-in -80.48, 4.82 -65.53, -29.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.6 0.247 0.288 A 310 276 22 0 0 22 [[1078, 1339]] 1.0 3efj Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 5T3QA P08581 1050 1350 1390.0 75H:61401 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -142.6, 175.57 45.45, 999.0 279.25, -5.86 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.187 Saltbr-out 9.495 HRD-in -69.85, -55.7 82.52, -23.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 169.98 APE8-dihe-in -92.78, 65.48 APE8-rot-na 37.33 APE67-dihe-in -70.53, -2.22 -62.22, -34.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.582 None None None XRAY 2.0 0.198 0.248 A 309 277 24 0 0 22 [[1078, 1339]] 1.0 5t3q Homo sapiens TYR_MET_HUMAN TYR 7.1e-92 313.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNA P08581 1057 1351 1390.0 AM7:1 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -145.52, 173.92 -137.55, 999.0 29.69, -41.77 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.313 Saltbr-out 10.101 HRD-in -80.8, -43.71 73.65, -29.19 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 31.17 APE8-rot-na 23.12 APE67-dihe-in -68.97, -9.97 -50.29, -35.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.241 0.294 A 310 268 27 0 0 23 [[1078, 1339]] 1.0 2rfn Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 2RFNB P08581 1056 1351 1390.0 AM7:1 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-out -149.27, 171.85 -132.94, 999.0 345.81, 32.63 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 13.46 Saltbr-out 10.805 HRD-in -77.04, -45.81 74.29, -30.03 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 33.53 APE8-rot-na 35.74 APE67-dihe-in -65.01, -12.86 -49.25, -36.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.241 0.294 B 310 269 27 0 0 23 [[1078, 1339]] 1.0 2rfn Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJB P08581 1054 1351 1390.0 MT3:2 Type1.5_Front Inactive None 999.0 999.0 None DFGAsp-rot-in -130.74, -175.38 -145.16, 999.0 212.24, -25.22 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 13.373 Saltbr-none 999.0 HRD-in -71.19, -53.04 82.76, -19.12 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -10.37 APE8-rot-na 31.62 APE67-dihe-in -71.17, -12.51 -66.7, -29.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L1272L None None XRAY 2.6 0.247 0.288 B 310 275 23 0 0 23 [[1078, 1339]] 1.0 3efj Homo sapiens TYR_MET_HUMAN TYR 7.2e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR RET RET_HUMAN 7DU8A P07949 714 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.959 14.089 BLAminus DFGAsp-rot-in -139.9, -176.36 61.28, 71.22 180.69, 23.55 -96.57, 22.61 290.51, 82.58 -62.34, -43.12 in-in in 7.246 Saltbr-in 2.725 HRD-in -70.49, -42.48 76.18, -46.1 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.78, 19.85 APE9-dihe-in -91.59, 136.68 APE8-dihe-in -57.27, 135.39 APE8-rot-na 326.69 APE67-dihe-in -68.65, -17.13 -56.96, -36.43 APE12-dist-na 13.472 APE11-dist-na 9.218 APE10-dist-na 7.3 APE9-dist-na 5.634 None None None XRAY 2.75 0.217 0.277 A 314 286 13 0 0 0 [[724, 1007]] 1.0 7du8 Homo sapiens TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7DU8B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.866 14.457 BLAminus DFGAsp-rot-in -139.37, -177.62 63.4, 72.86 189.15, 35.21 -98.32, 23.3 293.23, 81.57 -64.12, -44.29 in-in in 7.349 Saltbr-in 3.227 HRD-in -70.76, -41.16 77.27, -46.88 in-in-out SNCiio in-out ActLoopNT-in 2.948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -119.72, 24.05 APE9-dihe-in -92.66, 135.69 APE8-dihe-in -57.1, 135.94 APE8-rot-na 330.01 APE67-dihe-in -67.74, -17.88 -57.22, -36.2 APE12-dist-na 12.963 APE11-dist-na 8.955 APE10-dist-na 7.341 APE9-dist-na 5.668 None None None XRAY 2.75 0.217 0.277 B 314 274 31 0 0 10 [[724, 1007]] 1.0 7du8 Homo sapiens TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 7JU6B P07949 705 1012 1114.0 Q6G:61101 Type1.5_Front Inactive DFGin 6.853 14.558 BLAminus DFGAsp-rot-in -133.87, -179.77 59.88, 75.8 189.5, 16.1 -96.18, 17.81 292.2, 77.2 -56.92, -30.18 in-in in 7.676 Saltbr-in 2.717 HRD-in -72.4, -43.27 78.98, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.91 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -109.34, 21.56 APE9-dihe-in -92.4, 131.54 APE8-dihe-in -51.97, 128.7 APE8-rot-na 329.4 APE67-dihe-in -67.8, -13.47 -45.61, -41.79 APE12-dist-na 13.246 APE11-dist-na 9.219 APE10-dist-na 7.607 APE9-dist-na 5.405 None None None XRAY 2.06 0.199 0.249 B 314 286 22 0 0 9 [[724, 1007]] 1.0 7ju6 Homo sapiens TYR_RET_HUMAN TYR 4.2e-101 343.6 1 261 261 891 892 893 895 897 758 775 779 871 873 872 874 933 921 916 915 914 913 912 911 910 805 Proto-oncogene tyrosine-protein kinase receptor Ret
TYR SYK KSYK_HUMAN 3TUCA P43405 358 633 635.0 FPW:999 Type1.5_Front Inactive DFGin 6.556 15.019 BLBplus DFGAsp-rot-out -114.33, 165.27 53.65, 40.82 279.53, -19.63 -73.1, 146.31 90.45, 83.64 -43.15, -55.01 out-out out 11.471 Saltbr-out 7.068 HRD-in -66.05, -58.66 86.11, -25.8 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.49 APE8-rot-na 24.54 APE67-dihe-in -67.39, -16.05 -47.1, -39.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.216 0.285 A 299 257 19 0 0 19 [[370, 628]] 1.0 3tuc Homo sapiens TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
CAMK AURKA AURKA_MOUSE 3D14A P97477 117 379 395.0 AK1:60001 Type1.5_Front Inactive DFGin 6.829 16.115 BLAminus DFGAsp-rot-in -139.07, 172.86 70.75, 85.85 191.15, -2.19 -101.44, 25.77 290.86, 79.7 -66.74, -24.1 out-out out 10.978 Saltbr-out 7.777 HRD-in -71.22, -52.01 70.27, -4.3 out-in-out SNCoio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.43 APE9-dihe-na -158.18, -138.37 APE8-dihe-in -81.17, 171.47 APE8-rot-out 71.66 APE67-dihe-in -52.26, -34.35 -85.54, 0.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.713 APE9-dist-out 10.882 N164G,K218R,M280L None None XRAY 1.9 0.213 0.257 A 272 257 6 0 0 6 [[124, 374]] 1.0 3d14 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D15A P97477 117 379 395.0 AK2:60001 Type1.5_Front Inactive DFGin 7.341 16.547 BLAminus DFGAsp-rot-in -133.09, 171.12 62.7, 82.59 197.04, -28.78 -93.04, 24.05 278.36, 81.94 -66.36, -33.72 out-out out 11.26 Saltbr-out 7.415 HRD-in -74.96, -54.78 78.32, -11.59 out-in-out SNCoio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -61.43, 168.75 APE8-rot-out 172.07 APE67-dihe-in -47.97, -35.28 -92.1, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.628 N164G,K218R,M280L None None XRAY 2.3 0.238 0.287 A 272 256 7 0 0 7 [[124, 374]] 1.0 3d15 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D2IA P97477 118 379 395.0 AK3:60001 Type1.5_Front Inactive DFGin 6.93 16.152 BLAminus DFGAsp-rot-in -138.38, 171.61 68.82, 84.95 210.53, -34.66 -100.0, 33.08 285.24, 81.68 -70.28, -40.3 out-out out 11.041 Saltbr-out 7.909 HRD-in -79.0, -48.65 68.62, -9.76 out-in-out SNCoio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -64.89 APE9-dihe-na -137.07, -130.76 APE8-dihe-in -91.86, 172.43 APE8-rot-out 65.59 APE67-dihe-in -40.2, -35.42 -84.93, -8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.336 APE9-dist-out 10.416 N164G,K218R,M280L None None XRAY 2.9 0.245 0.298 A 272 255 7 0 0 7 [[124, 374]] 1.0 3d2i Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D2KA P97477 119 379 395.0 AK4:60001 Type1.5_Front Inactive DFGin 7.154 16.099 BLAminus DFGAsp-rot-in -121.9, 166.39 73.54, 78.63 187.85, 22.87 -94.98, 32.39 279.69, 79.25 -71.49, -37.35 out-out out 10.939 Saltbr-out 7.275 HRD-in -71.67, -45.16 66.48, -9.73 out-in-out SNCoio in-out ActLoopNT-in 3.239 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.82 APE8-rot-out 51.06 APE67-dihe-in -54.24, -21.42 -103.79, -17.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,M280L None None XRAY 2.5 0.223 0.273 A 272 245 16 0 0 11 [[124, 374]] 1.0 3d2k Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ7A P97477 117 379 395.0 AK7:60001 Type1.5_Front Inactive DFGin 6.747 16.264 BLAminus DFGAsp-rot-in -136.71, 173.78 65.51, 86.14 201.13, -20.92 -100.61, 22.92 284.54, 84.94 -64.18, -29.0 out-out out 11.144 Saltbr-out 7.502 HRD-in -76.06, -47.14 68.45, -12.93 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -39.63 APE9-dihe-na -153.17, -157.42 APE8-dihe-in -67.83, 166.09 APE8-rot-out 60.32 APE67-dihe-in -43.83, -37.54 -88.19, -6.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.644 APE9-dist-out 10.494 N164G,K218R,M280L None None XRAY 2.8 0.269 0.296 A 272 257 6 0 0 6 [[124, 374]] 1.0 3dj7 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.628 14.047 None DFGAsp-rot-out -136.29, 19.35 -86.03, 63.82 60.96, -39.07 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.905 APE11-dist-out 15.549 APE10-dist-out 15.409 APE9-dist-out 17.251 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272 252 9 0 0 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.511 14.321 None DFGAsp-rot-out -137.4, 19.75 -87.35, 63.1 63.91, -39.91 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.942 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.131 APE11-dist-out 15.714 APE10-dist-out 15.886 APE9-dist-out 17.36 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272 252 9 0 0 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
TYR BTK BTK_MOUSE 9EJJA P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.761 13.649 BLBplus DFGAsp-rot-out -147.32, 173.09 58.85, 28.19 290.6, 3.06 -76.07, 130.26 40.28, 86.74 72.63, 22.79 out-out out 15.391 Saltbr-out 16.721 HRD-in -81.76, -55.09 79.59, -6.11 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_oooai APEdist_aaaa APE10-dihe-out -88.9, -177.8 APE9-dihe-out -69.14, -44.42 APE8-dihe-out -58.97, -6.69 APE8-rot-na 334.43 APE67-dihe-in -64.23, -15.53 -59.83, -30.31 APE12-dist-na 999.0 APE11-dist-na 19.696 APE10-dist-na 15.002 APE9-dist-na 11.026 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 A 279 258 8 0 0 7 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJJB P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.501 14.073 BLBplus DFGAsp-rot-out -153.48, 175.7 63.93, 27.52 287.58, -3.02 -79.9, 134.25 41.75, 85.89 73.22, 13.03 out-out out 16.475 Saltbr-out 15.515 HRD-in -79.13, -52.93 77.61, -0.8 out-out-out SNCooo out-out ActLoopNT-out 7.904 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -93.15, 172.37 APE9-dihe-out -61.71, -38.19 APE8-dihe-out -62.73, -3.38 APE8-rot-na 336.57 APE67-dihe-in -68.39, -9.76 -59.68, -31.05 APE12-dist-na 999.0 APE11-dist-na 19.478 APE10-dist-na 14.504 APE9-dist-na 10.867 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 B 279 256 10 0 0 8 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJRA P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.915 13.644 BLBplus DFGAsp-rot-out -146.74, 166.14 62.28, 23.66 288.09, 0.94 -68.17, 124.47 38.27, 88.12 78.54, 14.19 out-out out 15.699 Saltbr-out 15.741 HRD-in -72.31, -57.13 80.67, 0.3 out-out-out SNCooo out-out ActLoopNT-out 7.816 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -92.94, 175.88 APE9-dihe-out -65.52, -38.77 APE8-dihe-out -63.32, -1.31 APE8-rot-na 335.74 APE67-dihe-in -69.18, -9.94 -59.0, -31.83 APE12-dist-na 21.489 APE11-dist-na 20.061 APE10-dist-na 15.137 APE9-dist-na 11.12 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 A 279 260 6 0 0 6 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJRB P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.579 14.023 BLBplus DFGAsp-rot-out -146.82, 168.57 65.02, 26.83 286.14, -7.4 -69.27, 132.22 36.8, 90.68 70.75, 10.33 out-out out 16.126 Saltbr-out 17.377 HRD-in -76.4, -57.97 82.93, -6.46 out-out-out SNCooo out-out ActLoopNT-out 7.898 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -73.95, 158.19 APE9-dihe-out -60.45, -36.51 APE8-dihe-out -63.06, -4.13 APE8-rot-na 335.95 APE67-dihe-in -67.11, -17.18 -54.59, -31.21 APE12-dist-na 999.0 APE11-dist-na 19.985 APE10-dist-na 13.976 APE9-dist-na 10.882 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 B 279 256 10 0 0 8 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSA P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 6.097 14.093 BLBplus DFGAsp-rot-out -154.67, 173.53 58.61, 37.48 280.82, -31.99 -82.66, 135.95 37.6, 82.44 70.22, 5.22 out-none out 15.429 Saltbr-none 999.0 HRD-in -84.8, -55.83 84.5, -7.48 none-out-out SNCnoo out-out ActLoopNT-out 8.101 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -110.34, 5.15 APE9-dihe-in -73.07, 137.61 APE8-dihe-in -77.55, 68.34 APE8-rot-na 30.59 APE67-dihe-in -71.3, -7.86 -58.39, -36.7 APE12-dist-na 16.663 APE11-dist-na 18.581 APE10-dist-na 13.537 APE9-dist-na 8.47 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 A 271 264 0 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSB P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.686 14.036 BLBplus DFGAsp-rot-out -156.42, 172.76 60.49, 20.29 284.86, -18.85 -63.05, 132.72 45.29, 85.58 77.61, -1.77 out-none out 15.225 Saltbr-none 999.0 HRD-in -73.66, -56.25 84.42, -8.07 none-out-out SNCnoo out-out ActLoopNT-out 7.622 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -122.47, 7.16 APE9-dihe-in -70.4, 144.43 APE8-dihe-in -80.98, 77.13 APE8-rot-na 29.28 APE67-dihe-in -72.16, -5.06 -62.4, -44.39 APE12-dist-na 16.636 APE11-dist-na 18.73 APE10-dist-na 13.869 APE9-dist-na 8.644 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 B 271 262 2 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSC P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.736 13.805 BLBplus DFGAsp-rot-out -149.75, 171.22 61.78, 31.3 288.03, -31.63 -76.97, 128.5 43.86, 90.23 72.89, 21.93 out-none out 14.958 Saltbr-none 999.0 HRD-in -89.58, -48.29 82.25, -17.58 none-out-out SNCnoo out-out ActLoopNT-out 7.873 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -125.95, 7.94 APE9-dihe-in -72.64, 139.26 APE8-dihe-in -74.43, 65.15 APE8-rot-na 26.63 APE67-dihe-in -70.23, -10.99 -55.69, -40.73 APE12-dist-na 16.965 APE11-dist-na 18.73 APE10-dist-na 13.812 APE9-dist-na 8.549 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 C 271 264 0 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
CMGC MPS1 MPS1_PYRO7 8H59A G4N374 5 412 415.0 KR9:501 Type1.5_Front Inactive DFGin 5.956 15.366 BLAminus DFGAsp-rot-in -134.85, 173.26 70.85, 86.1 200.19, -20.38 -93.21, 14.91 286.31, 97.32 -67.37, -25.49 in-in in 9.041 Saltbr-in 3.033 HRD-in -67.24, -45.34 79.73, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.72 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.85, 139.82 APE9-dihe-na -77.1, 173.87 APE8-dihe-in -76.55, 127.71 APE8-rot-in 308.36 APE67-dihe-in -58.6, -29.07 -61.68, -44.62 APE12-dist-in 7.28 APE11-dist-out 5.653 APE10-dist-out 9.255 APE9-dist-in 4.462 None None None XRAY 2.15 0.178 0.203 A 408 375 0 0 0 0 [[23, 314]] 1.0 8h59 Pyricularia oryzae CMGC_MPS1_PYRO7 CMGC 1.4e-78 270.2 1 301 301 166 167 168 170 172 52 70 74 146 148 147 149 211 198 193 192 191 190 189 188 187 105 Mitogen-activated protein kinase MPS1
CMGC MAPK1 MK01_RAT 4XOZA P63086 8 354 358.0 620:401 Type1.5_Front Inactive DFGin 7.034 17.18 BLAminus DFGAsp-rot-in -134.11, -179.17 64.03, 75.89 237.16, -74.57 -98.44, 22.92 284.72, 79.08 -64.36, -27.3 out-out out 10.954 Saltbr-out 7.058 HRD-in -69.47, -52.23 72.29, -1.02 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.18, -18.66 APE9-dihe-na -75.46, 166.86 APE8-dihe-in -66.79, 127.73 APE8-rot-in 308.37 APE67-dihe-in -59.61, -18.58 -53.08, -50.65 APE12-dist-out 14.394 APE11-dist-in 11.073 APE10-dist-in 7.364 APE9-dist-in 4.474 None None CME159 XRAY 1.95 0.147 0.188 A 351 342 0 0 0 0 [[23, 311]] 1.0 4xoz Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.3 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4QYYA P63086 13 353 358.0 3G7:401 Type1.5_Front Inactive DFGin 6.725 16.39 BLAminus DFGAsp-rot-in -132.71, 173.31 70.0, 86.57 201.52, -14.83 -103.46, 23.97 286.71, 76.13 -60.77, -27.68 in-in in 9.537 Saltbr-in 2.6 HRD-in -74.52, -50.72 73.19, 8.77 in-in-out SNCiio in-out ActLoopNT-in 2.785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.27, -36.79 APE9-dihe-na -64.89, 158.32 APE8-dihe-in -46.41, 120.56 APE8-rot-in 314.36 APE67-dihe-in -60.78, -19.5 -50.53, -52.6 APE12-dist-out 14.381 APE11-dist-in 11.107 APE10-dist-in 7.3 APE9-dist-in 4.426 None None None XRAY 1.65 0.229 0.259 A 365 337 0 0 0 0 [[23, 311]] 1.0 4qyy Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 5HD4A P63086 9 355 358.0 38Z:401 Type1.5_Front Inactive DFGin 6.762 16.396 BLAminus DFGAsp-rot-in -132.15, 171.71 72.04, 89.95 200.08, -17.89 -105.49, 25.28 288.89, 74.15 -62.94, -29.6 in-in in 9.609 Saltbr-in 2.651 HRD-in -73.9, -52.49 73.6, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.81, -40.96 APE9-dihe-na -60.91, 155.22 APE8-dihe-in -46.4, 120.98 APE8-rot-in 315.89 APE67-dihe-in -62.79, -18.63 -49.8, -50.9 APE12-dist-out 14.32 APE11-dist-in 11.068 APE10-dist-in 7.16 APE9-dist-in 4.436 None None None XRAY 1.45 0.177 0.199 A 365 347 0 0 0 0 [[23, 311]] 1.0 5hd4 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 6CPWA P63086 16 355 358.0 F8V:403 Type1.5_Front Inactive DFGin 6.729 16.433 BLAminus DFGAsp-rot-in -131.65, 172.57 66.32, 87.15 200.55, -9.94 -102.19, 23.21 287.0, 74.02 -60.73, -27.83 in-in in 9.74 Saltbr-in 2.61 HRD-in -72.55, -51.86 72.75, 5.47 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.83, -38.85 APE9-dihe-na -58.06, 150.18 APE8-dihe-in -41.46, 122.36 APE8-rot-in 313.47 APE67-dihe-in -62.43, -17.55 -55.27, -49.2 APE12-dist-out 14.418 APE11-dist-in 11.112 APE10-dist-in 7.425 APE9-dist-in 4.403 None None None XRAY 1.85 0.19 0.224 A 366 328 5 0 0 0 [[23, 311]] 1.0 6cpw Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 6DCGA P63086 16 354 358.0 G67:403 Type1.5_Front Inactive DFGin 6.738 16.311 BLAminus DFGAsp-rot-in -128.96, 170.91 70.91, 87.53 199.29, -11.95 -102.77, 23.72 285.91, 75.71 -65.7, -26.65 in-in in 9.578 Saltbr-in 2.587 HRD-in -74.26, -51.41 73.54, 7.44 in-in-out SNCiio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.1, -35.07 APE9-dihe-na -65.64, 158.57 APE8-dihe-in -47.89, 121.75 APE8-rot-in 313.14 APE67-dihe-in -64.08, -17.48 -49.3, -51.53 APE12-dist-out 14.452 APE11-dist-in 11.117 APE10-dist-in 7.306 APE9-dist-in 4.373 None None None XRAY 1.45 0.178 0.199 A 366 326 5 0 0 0 [[23, 311]] 1.0 6dcg Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5DRBA Q9JIH7 209 481 2126.0 5FJ:501 Type1.5_Front Inactive DFGin 6.415 15.243 BLBtrans DFGAsp-rot-out -102.41, 174.78 66.6, 17.24 285.06, 13.49 -54.98, 136.9 200.01, 54.53 87.03, -12.43 na-na na 15.693 Saltbr-na 999.0 HRD-in -69.28, -52.98 81.61, -10.52 na-out-out SNCaoo out-out ActLoopNT-out 7.608 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -157.99, 142.74 APE9-dihe-na 70.29, -166.96 APE8-dihe-in -67.0, 128.15 APE8-rot-out 148.06 APE67-dihe-out -98.12, 161.39 -68.79, 138.19 APE12-dist-out 18.331 APE11-dist-out 21.629 APE10-dist-out 19.494 APE9-dist-out 17.674 S382A None None XRAY 1.65 0.199 0.24 A 291 273 0 0 0 0 [[220, 479]] 1.0 5drb Rattus norvegicus OTHER_WNK1_RAT WNK 7.3e-180 601.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Inactive DFGin 6.754 15.371 BLAminus DFGAsp-rot-out -131.59, 172.16 63.96, 73.04 291.02, -28.5 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.658 Saltbr-in 2.783 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.88 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.731 APE11-dist-na 11.145 APE10-dist-na 14.707 APE9-dist-na 11.713 None None None XRAY 1.997 0.185 0.222 A 261 236 21 0 0 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5.2e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
CAMK AURKBA AUKBA_XENLA 2VRXA Q6DE08 87 355 361.0 447:1356 Type1.5_Front Inactive DFGin 5.42 15.778 ABAminus DFGAsp-rot-in -105.62, -30.67 -123.67, 131.33 185.58, 88.51 -117.99, 34.15 285.03, 83.66 -62.28, -30.72 out-out out 10.682 Saltbr-out 8.585 HRD-in -81.76, -55.95 77.01, 3.35 out-in-in SNCoii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.89, 162.13 APE9-dihe-na 112.16, -139.2 APE8-dihe-in -134.38, 133.56 APE8-rot-in 313.33 APE67-dihe-in -66.93, -14.33 -36.35, -56.78 APE12-dist-in 8.24 APE11-dist-in 10.984 APE10-dist-in 5.366 APE9-dist-in 3.599 None TPO248 TPO248 XRAY 1.86 0.191 0.243 A 285 269 0 0 0 0 [[93, 343]] 1.0 2vrx Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2VA Q6DE08 87 357 361.0 YJA:1357 Type1.5_Front Inactive DFGin 5.69 15.549 ABAminus DFGAsp-rot-in -108.16, -35.27 -114.73, 124.49 189.1, -80.08 -117.48, 35.02 287.24, 73.89 -61.26, -33.55 out-out out 10.498 Saltbr-out 6.613 HRD-in -78.14, -58.65 78.38, 3.8 out-in-in SNCoii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.3, 162.85 APE9-dihe-na 114.08, -146.04 APE8-dihe-in -135.51, 133.89 APE8-rot-in 294.11 APE67-dihe-in -71.33, -17.09 -36.81, -55.94 APE12-dist-in 8.288 APE11-dist-in 10.871 APE10-dist-in 5.538 APE9-dist-in 3.614 None TPO248 TPO248 XRAY 1.49 0.168 0.197 A 285 271 0 0 0 0 [[93, 343]] 1.0 4c2v Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2VB Q6DE08 76 356 361.0 YJA:1357 Type1.5_Front Inactive DFGin 5.942 15.883 ABAminus DFGAsp-rot-in -109.55, -42.74 -106.71, 117.87 194.43, -38.22 -113.37, 30.44 284.56, 79.44 -66.62, -22.24 out-out out 10.936 Saltbr-out 5.894 HRD-in -82.35, -52.94 75.14, -4.14 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.26, 161.88 APE9-dihe-na 127.85, -152.7 APE8-dihe-in -130.87, 132.44 APE8-rot-in 296.15 APE67-dihe-in -67.07, -19.19 -44.45, -53.34 APE12-dist-in 8.111 APE11-dist-in 10.915 APE10-dist-in 5.332 APE9-dist-in 3.644 None TPO248 TPO248 XRAY 1.49 0.168 0.197 B 285 281 0 0 0 0 [[93, 343]] 1.0 4c2v Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A

All / All / Type1.5_Front

Total number of chains: 33
Active chains: 0
Total number of genes: 11
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 15 45.5% 5HD4A
DFGin BLBplus 7 21.2% 9EJSA
DFGin ABAminus 4 12.1% 4C2VA
DFGin BLBminus 3 9.1% 4DGGA
DFGin None 3 9.1% 3DJ6A
DFGin BLBtrans 1 3.0% 5DRBA

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK5 GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.267 12.797 ABAminus DFGAsp-rot-in -122.04, -4.62 -137.77, 133.15 190.13, -65.06 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.484 Saltbr-in 2.781 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.951 APE10-dist-in 6.101 APE9-dist-in 3.92 None None None XRAY 2.42 0.196 0.243 A 598 499 0 0 0 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.3e-84 288.8 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PRKACA KAPCA_BOVIN 1XH9A P00517 14 351 351.0 R69:60351 Type1.5_Front Inactive DFGin 6.209 14.353 BLAminus DFGAsp-rot-out -129.75, -179.11 60.33, 73.87 284.38, -8.82 -88.04, 22.6 274.32, 67.63 -61.73, -24.72 in-in in 8.581 Saltbr-in 2.609 HRD-in -83.79, -50.21 70.28, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.47, 163.02 APE9-dihe-na 127.04, -169.55 APE8-dihe-in -104.83, 132.1 APE8-rot-in 300.02 APE67-dihe-in -61.76, -25.27 -43.65, -49.85 APE12-dist-in 8.298 APE11-dist-in 11.805 APE10-dist-in 6.219 APE9-dist-in 3.696 Q85E,V124A,L174M,Q182K,F188L TPO198,SEP339 TPO198,SEP339 XRAY 1.64 0.166 0.199 A 350 338 0 0 0 0 [[44, 298]] 1.0 1xh9 Bos taurus AGC_PRKACA_BOVIN AGC 1e-94 322.6 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SVHA P00517 15 351 351.0 I08:60351 Type1.5_Front Inactive DFGin 6.29 14.359 BLAminus DFGAsp-rot-out -115.3, -171.03 56.71, 72.97 299.69, 70.16 -89.54, 18.36 276.49, 75.83 -65.64, -21.28 in-in in 8.519 Saltbr-in 2.417 HRD-in -84.39, -53.98 69.64, 16.78 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.15, 156.51 APE9-dihe-na 127.45, -173.0 APE8-dihe-in -94.86, 131.95 APE8-rot-in 296.28 APE67-dihe-in -64.98, -17.24 -40.94, -52.95 APE12-dist-in 8.685 APE11-dist-in 11.721 APE10-dist-in 6.22 APE9-dist-in 3.712 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.214 0.259 A 350 337 0 0 0 0 [[44, 298]] 1.0 1svh Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK PLK1 Q4KMI8_DANRE 3DB6A Q4KMI8 24 310 595.0 FRS:1 Type1.5_Front Inactive DFGin 5.817 15.954 BLAminus DFGAsp-rot-in -142.4, -169.51 60.61, 84.89 174.3, 25.49 -102.5, 26.5 287.92, 83.73 -63.45, -15.75 out-out out 11.643 Saltbr-out 7.205 HRD-in -75.01, -40.51 67.41, -16.08 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -91.76, 87.23 APE9-dihe-na 133.88, 161.1 APE8-dihe-in -107.95, 116.2 APE8-rot-in 306.39 APE67-dihe-out -75.67, -58.88 -71.76, 164.15 APE12-dist-in 11.272 APE11-dist-out 7.484 APE10-dist-in 7.511 APE9-dist-out 8.776 T196D None None XRAY 2.85 0.225 0.257 A 301 287 0 0 0 0 [[39, 291]] 1.0 3db6 Danio rerio CAMK_PLK1_DANRE CAMK 9.2e-77 263.8 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
TYR SRC SRC_CHICK 4DGGA P00523 256 533 533.0 I76:601 Type1.5_Front Inactive DFGin 7.182 16.052 BLBminus DFGAsp-rot-in -138.93, 160.43 60.89, 77.08 214.6, 49.5 -83.17, 130.88 289.59, 69.05 -67.2, 999.0 out-none out 12.501 Saltbr-none 999.0 HRD-in -77.19, -53.85 87.04, -25.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.96 APE8-dihe-in -89.03, 71.14 APE8-rot-na 37.27 APE67-dihe-in -65.17, -28.22 -72.82, -18.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.855 None None None XRAY 2.65 0.21 0.252 A 286 261 17 0 0 17 [[267, 518]] 1.0 4dgg Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5J5SA P00523 258 533 533.0 6G3:601 Type1.5_Front Inactive DFGin 7.473 17.115 BLBminus DFGAsp-rot-out -139.23, 176.61 47.74, 68.55 291.15, -55.75 -62.62, 139.94 285.48, 65.31 -73.07, 999.0 out-out out 12.45 Saltbr-out 11.993 HRD-in -82.63, -54.31 82.21, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.84 APE8-rot-na 34.31 APE67-dihe-in -69.03, -18.92 -52.03, -32.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.153 0.17 0.216 A 286 258 18 0 0 18 [[267, 518]] 1.0 5j5s Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5J5SB P00523 256 533 533.0 6G3:601 Type1.5_Front Inactive DFGin 6.972 16.373 BLBminus DFGAsp-rot-out -139.39, 176.63 48.37, 68.06 289.4, -55.26 -63.65, 138.85 285.11, 65.43 -74.42, 999.0 out-out out 12.567 Saltbr-out 12.185 HRD-in -81.75, -53.76 82.55, -14.27 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 44.16 APE8-rot-na 34.77 APE67-dihe-in -70.17, -21.94 -51.94, -30.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.153 0.17 0.216 B 286 258 20 0 0 18 [[267, 518]] 1.0 5j5s Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3QLFB P00523 258 533 533.0 PD5:601 Type1.5_Front Inactive DFGin 6.141 12.601 None DFGAsp-rot-in -150.33, 164.09 75.91, 111.22 240.0, -40.51 -150.95, 999.0 2.54, 56.9 999.0, 999.0 out-none out 11.115 Saltbr-none 999.0 HRD-in -102.4, -44.0 81.56, -46.14 none-in-none SNCnin in-none ActLoopNT-in 3.221 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -83.83, 51.78 APE8-rot-na 4.43 APE67-dihe-in -63.43, -19.12 -50.83, -42.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 9.293 L317I None None XRAY 2.75 0.194 0.232 B 286 258 18 0 0 16 [[267, 518]] 1.0 3qlf Gallus gallus TYR_SRC_CHICK TYR 7.2e-94 319.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CAMK AURKA AURKA_MOUSE 3D14A P97477 117 379 395.0 AK1:60001 Type1.5_Front Inactive DFGin 6.829 16.115 BLAminus DFGAsp-rot-in -139.07, 172.86 70.75, 85.85 191.15, -2.19 -101.44, 25.77 290.86, 79.7 -66.74, -24.1 out-out out 10.978 Saltbr-out 7.777 HRD-in -71.22, -52.01 70.27, -4.3 out-in-out SNCoio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -30.43 APE9-dihe-na -158.18, -138.37 APE8-dihe-in -81.17, 171.47 APE8-rot-out 71.66 APE67-dihe-in -52.26, -34.35 -85.54, 0.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.713 APE9-dist-out 10.882 N164G,K218R,M280L None None XRAY 1.9 0.213 0.257 A 272 257 6 0 0 6 [[124, 374]] 1.0 3d14 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D15A P97477 117 379 395.0 AK2:60001 Type1.5_Front Inactive DFGin 7.341 16.547 BLAminus DFGAsp-rot-in -133.09, 171.12 62.7, 82.59 197.04, -28.78 -93.04, 24.05 278.36, 81.94 -66.36, -33.72 out-out out 11.26 Saltbr-out 7.415 HRD-in -74.96, -54.78 78.32, -11.59 out-in-out SNCoio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -61.43, 168.75 APE8-rot-out 172.07 APE67-dihe-in -47.97, -35.28 -92.1, -4.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.628 N164G,K218R,M280L None None XRAY 2.3 0.238 0.287 A 272 256 7 0 0 7 [[124, 374]] 1.0 3d15 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D2IA P97477 118 379 395.0 AK3:60001 Type1.5_Front Inactive DFGin 6.93 16.152 BLAminus DFGAsp-rot-in -138.38, 171.61 68.82, 84.95 210.53, -34.66 -100.0, 33.08 285.24, 81.68 -70.28, -40.3 out-out out 11.041 Saltbr-out 7.909 HRD-in -79.0, -48.65 68.62, -9.76 out-in-out SNCoio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -64.89 APE9-dihe-na -137.07, -130.76 APE8-dihe-in -91.86, 172.43 APE8-rot-out 65.59 APE67-dihe-in -40.2, -35.42 -84.93, -8.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.336 APE9-dist-out 10.416 N164G,K218R,M280L None None XRAY 2.9 0.245 0.298 A 272 255 7 0 0 7 [[124, 374]] 1.0 3d2i Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3D2KA P97477 119 379 395.0 AK4:60001 Type1.5_Front Inactive DFGin 7.154 16.099 BLAminus DFGAsp-rot-in -121.9, 166.39 73.54, 78.63 187.85, 22.87 -94.98, 32.39 279.69, 79.25 -71.49, -37.35 out-out out 10.939 Saltbr-out 7.275 HRD-in -71.67, -45.16 66.48, -9.73 out-in-out SNCoio in-out ActLoopNT-in 3.239 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.82 APE8-rot-out 51.06 APE67-dihe-in -54.24, -21.42 -103.79, -17.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,M280L None None XRAY 2.5 0.223 0.273 A 272 245 16 0 0 11 [[124, 374]] 1.0 3d2k Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ7A P97477 117 379 395.0 AK7:60001 Type1.5_Front Inactive DFGin 6.747 16.264 BLAminus DFGAsp-rot-in -136.71, 173.78 65.51, 86.14 201.13, -20.92 -100.61, 22.92 284.54, 84.94 -64.18, -29.0 out-out out 11.144 Saltbr-out 7.502 HRD-in -76.06, -47.14 68.45, -12.93 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -39.63 APE9-dihe-na -153.17, -157.42 APE8-dihe-in -67.83, 166.09 APE8-rot-out 60.32 APE67-dihe-in -43.83, -37.54 -88.19, -6.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.644 APE9-dist-out 10.494 N164G,K218R,M280L None None XRAY 2.8 0.269 0.296 A 272 257 6 0 0 6 [[124, 374]] 1.0 3dj7 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ5A P97477 119 379 395.0 AK5:60001 Type1.5_Front Inactive DFGin 7.628 14.047 None DFGAsp-rot-out -136.29, 19.35 -86.03, 63.82 60.96, -39.07 -110.83, -25.4 302.03, 108.73 -69.83, 159.06 out-out out 12.978 Saltbr-out 9.961 HRD-out -131.01, 157.62 -122.24, -24.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.12, -1.39 APE9-dihe-na 118.23, -161.25 APE8-dihe-in -83.03, 126.77 APE8-rot-in 300.87 APE67-dihe-in -53.36, -22.0 -45.96, -54.49 APE12-dist-out 14.905 APE11-dist-out 15.549 APE10-dist-out 15.409 APE9-dist-out 17.251 N164G,K218R,M280L None None XRAY 1.8 0.21 0.243 A 272 252 9 0 0 9 [[124, 374]] 1.0 3dj5 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
CAMK AURKA AURKA_MOUSE 3DJ6A P97477 119 379 395.0 AK6:60001 Type1.5_Front Inactive DFGin 7.511 14.321 None DFGAsp-rot-out -137.4, 19.75 -87.35, 63.1 63.91, -39.91 -109.74, -19.59 301.75, 109.1 -74.07, 159.87 out-out out 12.942 Saltbr-out 9.941 HRD-out -131.2, 158.79 -119.8, -29.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -104.43, 1.85 APE9-dihe-na 118.27, -159.99 APE8-dihe-in -81.23, 128.14 APE8-rot-in 303.03 APE67-dihe-in -53.67, -23.26 -47.45, -53.56 APE12-dist-out 15.131 APE11-dist-out 15.714 APE10-dist-out 15.886 APE9-dist-out 17.36 N164G,K218R,M280L None None XRAY 1.7 0.217 0.261 A 272 252 9 0 0 9 [[124, 374]] 1.0 3dj6 Mus musculus CAMK_AURKA_MOUSE CAMK 5e-80 274.5 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
TYR BTK BTK_MOUSE 9EJJA P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.761 13.649 BLBplus DFGAsp-rot-out -147.32, 173.09 58.85, 28.19 290.6, 3.06 -76.07, 130.26 40.28, 86.74 72.63, 22.79 out-out out 15.391 Saltbr-out 16.721 HRD-in -81.76, -55.09 79.59, -6.11 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_oooai APEdist_aaaa APE10-dihe-out -88.9, -177.8 APE9-dihe-out -69.14, -44.42 APE8-dihe-out -58.97, -6.69 APE8-rot-na 334.43 APE67-dihe-in -64.23, -15.53 -59.83, -30.31 APE12-dist-na 999.0 APE11-dist-na 19.696 APE10-dist-na 15.002 APE9-dist-na 11.026 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 A 279 258 8 0 0 7 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJJB P35991 394 659 659.0 A1BIZ:701 Type1.5_Front Inactive DFGin 5.501 14.073 BLBplus DFGAsp-rot-out -153.48, 175.7 63.93, 27.52 287.58, -3.02 -79.9, 134.25 41.75, 85.89 73.22, 13.03 out-out out 16.475 Saltbr-out 15.515 HRD-in -79.13, -52.93 77.61, -0.8 out-out-out SNCooo out-out ActLoopNT-out 7.904 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -93.15, 172.37 APE9-dihe-out -61.71, -38.19 APE8-dihe-out -62.73, -3.38 APE8-rot-na 336.57 APE67-dihe-in -68.39, -9.76 -59.68, -31.05 APE12-dist-na 999.0 APE11-dist-na 19.478 APE10-dist-na 14.504 APE9-dist-na 10.867 L390G,Y551E,Y617P None None XRAY 2.03 0.225 0.242 B 279 256 10 0 0 8 [[402, 653]] 1.0 9ejj Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJRA P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.915 13.644 BLBplus DFGAsp-rot-out -146.74, 166.14 62.28, 23.66 288.09, 0.94 -68.17, 124.47 38.27, 88.12 78.54, 14.19 out-out out 15.699 Saltbr-out 15.741 HRD-in -72.31, -57.13 80.67, 0.3 out-out-out SNCooo out-out ActLoopNT-out 7.816 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -92.94, 175.88 APE9-dihe-out -65.52, -38.77 APE8-dihe-out -63.32, -1.31 APE8-rot-na 335.74 APE67-dihe-in -69.18, -9.94 -59.0, -31.83 APE12-dist-na 21.489 APE11-dist-na 20.061 APE10-dist-na 15.137 APE9-dist-na 11.12 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 A 279 260 6 0 0 6 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJRB P35991 394 659 659.0 A1BI0:701 Type1.5_Front Inactive DFGin 5.579 14.023 BLBplus DFGAsp-rot-out -146.82, 168.57 65.02, 26.83 286.14, -7.4 -69.27, 132.22 36.8, 90.68 70.75, 10.33 out-out out 16.126 Saltbr-out 17.377 HRD-in -76.4, -57.97 82.93, -6.46 out-out-out SNCooo out-out ActLoopNT-out 7.898 ActLoopCT-out TYR APEdihe_iooai APEdist_aaaa APE10-dihe-in -73.95, 158.19 APE9-dihe-out -60.45, -36.51 APE8-dihe-out -63.06, -4.13 APE8-rot-na 335.95 APE67-dihe-in -67.11, -17.18 -54.59, -31.21 APE12-dist-na 999.0 APE11-dist-na 19.985 APE10-dist-na 13.976 APE9-dist-na 10.882 L390G,Y551E,Y617P None None XRAY 2.1 0.25 0.295 B 279 256 10 0 0 8 [[402, 653]] 1.0 9ejr Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSA P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 6.097 14.093 BLBplus DFGAsp-rot-out -154.67, 173.53 58.61, 37.48 280.82, -31.99 -82.66, 135.95 37.6, 82.44 70.22, 5.22 out-none out 15.429 Saltbr-none 999.0 HRD-in -84.8, -55.83 84.5, -7.48 none-out-out SNCnoo out-out ActLoopNT-out 8.101 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -110.34, 5.15 APE9-dihe-in -73.07, 137.61 APE8-dihe-in -77.55, 68.34 APE8-rot-na 30.59 APE67-dihe-in -71.3, -7.86 -58.39, -36.7 APE12-dist-na 16.663 APE11-dist-na 18.581 APE10-dist-na 13.537 APE9-dist-na 8.47 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 A 271 264 0 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSB P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.686 14.036 BLBplus DFGAsp-rot-out -156.42, 172.76 60.49, 20.29 284.86, -18.85 -63.05, 132.72 45.29, 85.58 77.61, -1.77 out-none out 15.225 Saltbr-none 999.0 HRD-in -73.66, -56.25 84.42, -8.07 none-out-out SNCnoo out-out ActLoopNT-out 7.622 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -122.47, 7.16 APE9-dihe-in -70.4, 144.43 APE8-dihe-in -80.98, 77.13 APE8-rot-na 29.28 APE67-dihe-in -72.16, -5.06 -62.4, -44.39 APE12-dist-na 16.636 APE11-dist-na 18.73 APE10-dist-na 13.869 APE9-dist-na 8.644 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 B 271 262 2 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 9EJSC P35991 396 659 659.0 A1BI0:60701 Type1.5_Front Inactive DFGin 5.736 13.805 BLBplus DFGAsp-rot-out -149.75, 171.22 61.78, 31.3 288.03, -31.63 -76.97, 128.5 43.86, 90.23 72.89, 21.93 out-none out 14.958 Saltbr-none 999.0 HRD-in -89.58, -48.29 82.25, -17.58 none-out-out SNCnoo out-out ActLoopNT-out 7.873 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -125.95, 7.94 APE9-dihe-in -72.64, 139.26 APE8-dihe-in -74.43, 65.15 APE8-rot-na 26.63 APE67-dihe-in -70.23, -10.99 -55.69, -40.73 APE12-dist-na 16.965 APE11-dist-na 18.73 APE10-dist-na 13.812 APE9-dist-na 8.549 K430R,L542M,S543T,V555T,R562K,S564A,P565S,Y617P None None XRAY 2.26 0.194 0.246 C 271 264 0 0 0 0 [[402, 653]] 1.0 9ejs Mus musculus TYR_BTK_MOUSE TYR 1.1e-92 316.0 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
CMGC MPS1 MPS1_PYRO7 8H59A G4N374 5 412 415.0 KR9:501 Type1.5_Front Inactive DFGin 5.956 15.366 BLAminus DFGAsp-rot-in -134.85, 173.26 70.85, 86.1 200.19, -20.38 -93.21, 14.91 286.31, 97.32 -67.37, -25.49 in-in in 9.041 Saltbr-in 3.033 HRD-in -67.24, -45.34 79.73, -13.71 in-in-out SNCiio in-out ActLoopNT-in 2.72 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -91.85, 139.82 APE9-dihe-na -77.1, 173.87 APE8-dihe-in -76.55, 127.71 APE8-rot-in 308.36 APE67-dihe-in -58.6, -29.07 -61.68, -44.62 APE12-dist-in 7.28 APE11-dist-out 5.653 APE10-dist-out 9.255 APE9-dist-in 4.462 None None None XRAY 2.15 0.178 0.203 A 408 375 0 0 0 0 [[23, 314]] 1.0 8h59 Pyricularia oryzae CMGC_MPS1_PYRO7 CMGC 1.4e-78 270.2 1 301 301 166 167 168 170 172 52 70 74 146 148 147 149 211 198 193 192 191 190 189 188 187 105 Mitogen-activated protein kinase MPS1
CMGC MAPK1 MK01_RAT 4XOZA P63086 8 354 358.0 620:401 Type1.5_Front Inactive DFGin 7.034 17.18 BLAminus DFGAsp-rot-in -134.11, -179.17 64.03, 75.89 237.16, -74.57 -98.44, 22.92 284.72, 79.08 -64.36, -27.3 out-out out 10.954 Saltbr-out 7.058 HRD-in -69.47, -52.23 72.29, -1.02 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.18, -18.66 APE9-dihe-na -75.46, 166.86 APE8-dihe-in -66.79, 127.73 APE8-rot-in 308.37 APE67-dihe-in -59.61, -18.58 -53.08, -50.65 APE12-dist-out 14.394 APE11-dist-in 11.073 APE10-dist-in 7.364 APE9-dist-in 4.474 None None CME159 XRAY 1.95 0.147 0.188 A 351 342 0 0 0 0 [[23, 311]] 1.0 4xoz Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.3 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4QYYA P63086 13 353 358.0 3G7:401 Type1.5_Front Inactive DFGin 6.725 16.39 BLAminus DFGAsp-rot-in -132.71, 173.31 70.0, 86.57 201.52, -14.83 -103.46, 23.97 286.71, 76.13 -60.77, -27.68 in-in in 9.537 Saltbr-in 2.6 HRD-in -74.52, -50.72 73.19, 8.77 in-in-out SNCiio in-out ActLoopNT-in 2.785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.27, -36.79 APE9-dihe-na -64.89, 158.32 APE8-dihe-in -46.41, 120.56 APE8-rot-in 314.36 APE67-dihe-in -60.78, -19.5 -50.53, -52.6 APE12-dist-out 14.381 APE11-dist-in 11.107 APE10-dist-in 7.3 APE9-dist-in 4.426 None None None XRAY 1.65 0.229 0.259 A 365 337 0 0 0 0 [[23, 311]] 1.0 4qyy Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 5HD4A P63086 9 355 358.0 38Z:401 Type1.5_Front Inactive DFGin 6.762 16.396 BLAminus DFGAsp-rot-in -132.15, 171.71 72.04, 89.95 200.08, -17.89 -105.49, 25.28 288.89, 74.15 -62.94, -29.6 in-in in 9.609 Saltbr-in 2.651 HRD-in -73.9, -52.49 73.6, 6.76 in-in-out SNCiio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.81, -40.96 APE9-dihe-na -60.91, 155.22 APE8-dihe-in -46.4, 120.98 APE8-rot-in 315.89 APE67-dihe-in -62.79, -18.63 -49.8, -50.9 APE12-dist-out 14.32 APE11-dist-in 11.068 APE10-dist-in 7.16 APE9-dist-in 4.436 None None None XRAY 1.45 0.177 0.199 A 365 347 0 0 0 0 [[23, 311]] 1.0 5hd4 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 6CPWA P63086 16 355 358.0 F8V:403 Type1.5_Front Inactive DFGin 6.729 16.433 BLAminus DFGAsp-rot-in -131.65, 172.57 66.32, 87.15 200.55, -9.94 -102.19, 23.21 287.0, 74.02 -60.73, -27.83 in-in in 9.74 Saltbr-in 2.61 HRD-in -72.55, -51.86 72.75, 5.47 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -95.83, -38.85 APE9-dihe-na -58.06, 150.18 APE8-dihe-in -41.46, 122.36 APE8-rot-in 313.47 APE67-dihe-in -62.43, -17.55 -55.27, -49.2 APE12-dist-out 14.418 APE11-dist-in 11.112 APE10-dist-in 7.425 APE9-dist-in 4.403 None None None XRAY 1.85 0.19 0.224 A 366 328 5 0 0 0 [[23, 311]] 1.0 6cpw Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 6DCGA P63086 16 354 358.0 G67:403 Type1.5_Front Inactive DFGin 6.738 16.311 BLAminus DFGAsp-rot-in -128.96, 170.91 70.91, 87.53 199.29, -11.95 -102.77, 23.72 285.91, 75.71 -65.7, -26.65 in-in in 9.578 Saltbr-in 2.587 HRD-in -74.26, -51.41 73.54, 7.44 in-in-out SNCiio in-out ActLoopNT-in 2.815 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.1, -35.07 APE9-dihe-na -65.64, 158.57 APE8-dihe-in -47.89, 121.75 APE8-rot-in 313.14 APE67-dihe-in -64.08, -17.48 -49.3, -51.53 APE12-dist-out 14.452 APE11-dist-in 11.117 APE10-dist-in 7.306 APE9-dist-in 4.373 None None None XRAY 1.45 0.178 0.199 A 366 326 5 0 0 0 [[23, 311]] 1.0 6dcg Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5DRBA Q9JIH7 209 481 2126.0 5FJ:501 Type1.5_Front Inactive DFGin 6.415 15.243 BLBtrans DFGAsp-rot-out -102.41, 174.78 66.6, 17.24 285.06, 13.49 -54.98, 136.9 200.01, 54.53 87.03, -12.43 na-na na 15.693 Saltbr-na 999.0 HRD-in -69.28, -52.98 81.61, -10.52 na-out-out SNCaoo out-out ActLoopNT-out 7.608 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -157.99, 142.74 APE9-dihe-na 70.29, -166.96 APE8-dihe-in -67.0, 128.15 APE8-rot-out 148.06 APE67-dihe-out -98.12, 161.39 -68.79, 138.19 APE12-dist-out 18.331 APE11-dist-out 21.629 APE10-dist-out 19.494 APE9-dist-out 17.674 S382A None None XRAY 1.65 0.199 0.24 A 291 273 0 0 0 0 [[220, 479]] 1.0 5drb Rattus norvegicus OTHER_WNK1_RAT WNK 7.3e-180 601.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Inactive DFGin 6.754 15.371 BLAminus DFGAsp-rot-out -131.59, 172.16 63.96, 73.04 291.02, -28.5 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.658 Saltbr-in 2.783 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.88 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.731 APE11-dist-na 11.145 APE10-dist-na 14.707 APE9-dist-na 11.713 None None None XRAY 1.997 0.185 0.222 A 261 236 21 0 0 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5.2e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
CAMK AURKBA AUKBA_XENLA 2VRXA Q6DE08 87 355 361.0 447:1356 Type1.5_Front Inactive DFGin 5.42 15.778 ABAminus DFGAsp-rot-in -105.62, -30.67 -123.67, 131.33 185.58, 88.51 -117.99, 34.15 285.03, 83.66 -62.28, -30.72 out-out out 10.682 Saltbr-out 8.585 HRD-in -81.76, -55.95 77.01, 3.35 out-in-in SNCoii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.89, 162.13 APE9-dihe-na 112.16, -139.2 APE8-dihe-in -134.38, 133.56 APE8-rot-in 313.33 APE67-dihe-in -66.93, -14.33 -36.35, -56.78 APE12-dist-in 8.24 APE11-dist-in 10.984 APE10-dist-in 5.366 APE9-dist-in 3.599 None TPO248 TPO248 XRAY 1.86 0.191 0.243 A 285 269 0 0 0 0 [[93, 343]] 1.0 2vrx Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2VA Q6DE08 87 357 361.0 YJA:1357 Type1.5_Front Inactive DFGin 5.69 15.549 ABAminus DFGAsp-rot-in -108.16, -35.27 -114.73, 124.49 189.1, -80.08 -117.48, 35.02 287.24, 73.89 -61.26, -33.55 out-out out 10.498 Saltbr-out 6.613 HRD-in -78.14, -58.65 78.38, 3.8 out-in-in SNCoii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.3, 162.85 APE9-dihe-na 114.08, -146.04 APE8-dihe-in -135.51, 133.89 APE8-rot-in 294.11 APE67-dihe-in -71.33, -17.09 -36.81, -55.94 APE12-dist-in 8.288 APE11-dist-in 10.871 APE10-dist-in 5.538 APE9-dist-in 3.614 None TPO248 TPO248 XRAY 1.49 0.168 0.197 A 285 271 0 0 0 0 [[93, 343]] 1.0 4c2v Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2VB Q6DE08 76 356 361.0 YJA:1357 Type1.5_Front Inactive DFGin 5.942 15.883 ABAminus DFGAsp-rot-in -109.55, -42.74 -106.71, 117.87 194.43, -38.22 -113.37, 30.44 284.56, 79.44 -66.62, -22.24 out-out out 10.936 Saltbr-out 5.894 HRD-in -82.35, -52.94 75.14, -4.14 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.26, 161.88 APE9-dihe-na 127.85, -152.7 APE8-dihe-in -130.87, 132.44 APE8-rot-in 296.15 APE67-dihe-in -67.07, -19.19 -44.45, -53.34 APE12-dist-in 8.111 APE11-dist-in 10.915 APE10-dist-in 5.332 APE9-dist-in 3.644 None TPO248 TPO248 XRAY 1.49 0.168 0.197 B 285 281 0 0 0 0 [[93, 343]] 1.0 4c2v Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.6e-77 265.6 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A