All / Activity_Active / All

Total number of chains: 3027
Active chains: 3027
Total number of genes: 437
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3026 100.0% AF-P31749-K1A
DFGin ABAminus 1 0.0% AF-Q504Y2-K3A
All chains
No PyMOL session because the query has >1000 chains
Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.048 13.113 BLAminus DFGAsp-rot-in -112.5, -177.27 66.46, 90.66 198.98, 2.5 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.651 Saltbr-in 2.978 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.814 APE11-dist-in 11.718 APE10-dist-in 6.07 APE9-dist-in 4.069 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.075 13.046 BLAminus DFGAsp-rot-in -112.98, 175.61 60.18, 117.01 197.33, 0.64 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.766 Saltbr-in 2.665 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.77 APE11-dist-in 11.686 APE10-dist-in 6.125 APE9-dist-in 4.285 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN AF-P31749-K1A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 6.263 13.145 BLAminus DFGAsp-rot-in -114.62, -167.38 40.57, 67.78 207.16, 11.22 -78.23, 20.61 301.26, 84.0 -56.98, -40.88 in-in in 8.68 Saltbr-in 2.68 HRD-in -78.93, -42.17 64.1, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.25, 159.39 APE9-dihe-na 136.34, -176.15 APE8-dihe-in -90.74, 129.43 APE8-rot-in 299.37 APE67-dihe-in -70.7, -14.81 -47.91, -45.56 APE12-dist-in 8.322 APE11-dist-in 11.748 APE10-dist-in 6.046 APE9-dist-in 3.779 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[150, 408]] 1.0 AF-P31749-K1 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN AF-P31749-K3A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 5.861 13.331 BLAminus DFGAsp-rot-in -119.71, -175.9 43.31, 87.62 211.71, -12.35 -90.32, 18.66 297.34, 81.96 -61.74, -29.8 in-in in 8.79 Saltbr-in 2.698 HRD-in -81.85, -49.76 69.24, 0.24 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.64, 153.01 APE9-dihe-na 135.73, 179.27 APE8-dihe-in -81.81, 130.02 APE8-rot-in 289.58 APE67-dihe-in -69.79, -14.8 -47.58, -43.93 APE12-dist-in 8.487 APE11-dist-in 11.473 APE10-dist-in 5.866 APE9-dist-in 4.262 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[150, 408]] 1.0 AF-P31749-K3 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OW4A P31749 144 478 480.0 SMY:60001 Type1 Active DFGin 6.386 13.523 BLAminus DFGAsp-rot-in -119.32, 159.71 79.63, 82.83 211.82, -24.97 -104.78, 4.01 298.86, 82.1 -54.94, -24.29 in-in in 8.955 Saltbr-in 2.902 HRD-in -70.99, -49.36 69.67, -8.21 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.63, 156.89 APE9-dihe-na 142.86, -142.49 APE8-dihe-in -124.25, 130.13 APE8-rot-in 298.03 APE67-dihe-in -63.26, -12.53 -44.97, -47.55 APE12-dist-in 8.407 APE11-dist-in 11.499 APE10-dist-in 5.943 APE9-dist-in 4.122 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 A 341 318 0 0 0 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OW4B P31749 144 478 480.0 SMY:60002 Type1 Active DFGin 6.468 13.471 BLAminus DFGAsp-rot-in -110.6, 166.76 74.64, 94.72 203.85, -22.62 -107.78, 10.54 297.92, 88.21 -53.21, -30.59 in-in in 9.014 Saltbr-in 2.873 HRD-in -68.95, -46.49 77.32, -19.31 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 158.48 APE9-dihe-na 136.94, -160.6 APE8-dihe-in -112.04, 132.88 APE8-rot-in 279.55 APE67-dihe-in -64.15, -17.53 -43.71, -49.28 APE12-dist-in 8.567 APE11-dist-in 11.482 APE10-dist-in 6.0 APE9-dist-in 4.209 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 B 341 318 0 0 0 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.496 13.423 BLAminus DFGAsp-rot-in -130.08, 156.46 77.16, 99.77 202.35, -40.94 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.958 Saltbr-in 2.452 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.512 APE10-dist-in 6.011 APE9-dist-in 4.443 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341 330 0 0 0 0 [[150, 408]] 1.0 4ekl AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.734 BLAminus DFGAsp-rot-in -120.8, -176.05 56.87, 82.9 186.65, 12.61 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.749 Saltbr-in 2.796 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.193 APE11-dist-in 11.759 APE10-dist-in 6.119 APE9-dist-in 3.921 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336 318 0 0 0 0 [[152, 409]] 1.0 1o6k AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.258 12.925 BLAminus DFGAsp-rot-in -121.53, -178.18 58.41, 83.34 187.36, 7.04 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.794 Saltbr-in 2.76 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.173 APE11-dist-in 11.74 APE10-dist-in 6.122 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337 312 0 0 0 0 [[152, 409]] 1.0 1o6l AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN AF-P31751-K1A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 6.233 13.023 BLAminus DFGAsp-rot-in -113.23, -144.19 8.44, 78.9 204.72, 12.07 -80.27, 18.08 299.23, 85.15 -63.04, -27.98 in-in in 8.759 Saltbr-in 2.638 HRD-in -78.66, -46.08 65.41, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 154.65 APE9-dihe-na 130.96, 174.62 APE8-dihe-in -79.56, 129.32 APE8-rot-in 301.13 APE67-dihe-in -71.15, -16.28 -47.49, -43.65 APE12-dist-in 8.406 APE11-dist-in 11.677 APE10-dist-in 5.92 APE9-dist-in 3.689 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[152, 409]] 1.0 AF-P31751-K1 AGC_AKT2_HUMAN AGC 8.7e-100 339.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN AF-P31751-K3A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 5.926 12.937 BLAminus DFGAsp-rot-in -120.75, -176.12 46.87, 67.81 209.49, 9.39 -72.56, 16.67 304.47, 92.86 -64.84, -25.38 in-in in 8.908 Saltbr-in 2.672 HRD-in -85.04, -45.39 68.23, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.84, 152.71 APE9-dihe-na 130.61, 173.68 APE8-dihe-in -78.91, 130.99 APE8-rot-in 284.27 APE67-dihe-in -69.37, -17.14 -47.07, -44.67 APE12-dist-in 8.543 APE11-dist-in 11.658 APE10-dist-in 5.979 APE9-dist-in 3.74 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[152, 409]] 1.0 AF-P31751-K3 AGC_AKT2_HUMAN AGC 8.7e-100 339.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E87A P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.356 13.341 BLAminus DFGAsp-rot-in -126.04, 163.87 68.85, 90.68 210.97, -37.83 -105.7, 33.53 302.5, 89.72 -71.05, -31.02 in-in in 9.195 Saltbr-in 2.673 HRD-in -74.63, -46.2 65.87, 9.52 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 164.29 APE9-dihe-na 138.82, -139.79 APE8-dihe-in -129.72, 130.9 APE8-rot-in 295.88 APE67-dihe-in -69.5, -20.74 -43.13, -48.06 APE12-dist-in 8.258 APE11-dist-in 11.703 APE10-dist-in 6.114 APE9-dist-in 3.669 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 A 335 323 0 0 0 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E87B P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.363 13.328 BLAminus DFGAsp-rot-in -125.6, 164.26 67.65, 91.39 209.66, -39.85 -106.11, 33.4 302.92, 90.11 -70.63, -30.74 in-in in 9.207 Saltbr-in 2.657 HRD-in -73.89, -47.28 67.09, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 163.8 APE9-dihe-na 138.15, -140.19 APE8-dihe-in -128.95, 131.51 APE8-rot-in 293.83 APE67-dihe-in -69.92, -20.28 -43.71, -47.61 APE12-dist-in 8.266 APE11-dist-in 11.706 APE10-dist-in 6.115 APE9-dist-in 3.664 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 B 335 323 0 0 0 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2JDRA P31751 146 477 481.0 L20:61480 Type1 Active DFGin 6.289 13.187 BLAminus DFGAsp-rot-in -140.76, 154.56 67.85, 87.58 196.94, -1.01 -95.95, 16.78 295.18, 71.62 -47.79, -46.7 in-in in 8.713 Saltbr-in 2.796 HRD-in -80.08, -42.59 66.93, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 174.01 APE9-dihe-na 115.68, -166.42 APE8-dihe-in -112.23, 130.56 APE8-rot-in 296.59 APE67-dihe-in -62.74, -25.12 -49.6, -46.59 APE12-dist-in 7.942 APE11-dist-in 11.57 APE10-dist-in 6.023 APE9-dist-in 3.773 None TPO309 TPO309 XRAY 2.3 0.196 0.252 A 342 312 0 0 0 0 [[152, 409]] 1.0 2jdr AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3D0EA P31751 146 480 481.0 G93:1 Type1.5_Back Active DFGin 6.701 13.546 BLAminus DFGAsp-rot-in -125.73, 168.9 61.89, 84.21 205.68, -19.09 -95.51, 25.74 292.33, 79.73 -76.94, 1.71 in-in in 9.061 Saltbr-in 2.764 HRD-in -80.14, -42.28 68.95, -5.28 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.97, 167.33 APE9-dihe-na 127.67, -168.31 APE8-dihe-in -106.36, 125.11 APE8-rot-in 301.0 APE67-dihe-in -64.27, -20.07 -41.91, -50.48 APE12-dist-in 8.248 APE11-dist-in 11.661 APE10-dist-in 6.05 APE9-dist-in 4.016 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 A 335 324 0 0 0 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3D0EB P31751 146 480 481.0 G93:2 Type1.5_Back Active DFGin 6.809 13.565 BLAminus DFGAsp-rot-in -120.57, 168.95 62.61, 83.67 201.77, -13.94 -96.74, 28.63 294.15, 77.27 -76.08, -2.14 in-in in 9.13 Saltbr-in 2.993 HRD-in -78.43, -43.98 69.1, -0.1 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.44, 163.97 APE9-dihe-na 132.51, -165.35 APE8-dihe-in -107.37, 125.67 APE8-rot-in 301.69 APE67-dihe-in -66.88, -18.51 -42.11, -48.84 APE12-dist-in 8.237 APE11-dist-in 11.68 APE10-dist-in 6.04 APE9-dist-in 3.86 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 B 335 324 0 0 0 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E88A P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.577 13.405 BLAminus DFGAsp-rot-in -128.82, 173.63 61.99, 93.97 183.23, 13.27 -108.84, 31.73 297.8, 80.14 -73.82, -16.27 in-in in 9.196 Saltbr-in 2.832 HRD-in -75.09, -42.0 67.98, -2.73 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.37, 168.63 APE9-dihe-na 135.96, -142.36 APE8-dihe-in -130.12, 129.82 APE8-rot-in 291.65 APE67-dihe-in -63.55, -20.99 -45.06, -54.18 APE12-dist-in 8.073 APE11-dist-in 11.634 APE10-dist-in 6.003 APE9-dist-in 3.845 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 A 335 321 0 0 0 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E88B P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.509 13.327 BLAminus DFGAsp-rot-in -128.8, 173.14 62.13, 94.09 183.56, 26.77 -108.62, 31.59 298.9, 80.14 -73.92, -15.88 in-in in 9.208 Saltbr-in 2.724 HRD-in -75.96, -42.03 68.35, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.45, 168.65 APE9-dihe-na 136.37, -142.41 APE8-dihe-in -130.19, 130.02 APE8-rot-in 291.1 APE67-dihe-in -63.44, -20.2 -45.4, -53.85 APE12-dist-in 8.063 APE11-dist-in 11.626 APE10-dist-in 6.004 APE9-dist-in 3.853 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 B 335 321 0 0 0 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E8DA P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.627 13.602 BLAminus DFGAsp-rot-in -131.95, 161.19 63.93, 96.17 189.53, 2.68 -108.94, 28.77 296.25, 77.68 -84.56, 5.75 in-in in 9.2 Saltbr-in 2.805 HRD-in -77.32, -43.78 69.76, 5.0 in-in-in SNCiii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.79, 164.59 APE9-dihe-na 136.0, -148.3 APE8-dihe-in -124.36, 129.64 APE8-rot-in 293.72 APE67-dihe-in -64.33, -19.25 -43.26, -53.33 APE12-dist-in 8.087 APE11-dist-in 11.665 APE10-dist-in 5.995 APE9-dist-in 3.689 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 A 335 316 0 0 0 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E8DB P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.588 13.557 BLAminus DFGAsp-rot-in -130.8, 161.71 64.68, 95.04 189.0, 27.58 -108.93, 28.35 296.53, 82.54 -84.83, 6.03 in-in in 9.239 Saltbr-in 2.851 HRD-in -77.39, -43.59 70.5, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.079 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 165.61 APE9-dihe-na 135.83, -147.81 APE8-dihe-in -124.63, 129.91 APE8-rot-in 295.04 APE67-dihe-in -64.9, -18.78 -43.89, -52.5 APE12-dist-in 8.082 APE11-dist-in 11.649 APE10-dist-in 5.988 APE9-dist-in 3.707 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 B 335 318 0 0 0 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT3 AKT3_HUMAN AF-Q9Y243-K1A Q9Y243 140 413 479.0 No_ligand No_ligand Active DFGin 6.38 13.153 BLAminus DFGAsp-rot-in -112.11, -161.48 27.98, 82.03 205.73, 6.48 -85.83, 20.1 298.55, 83.88 -63.73, -28.06 in-in in 8.721 Saltbr-in 2.623 HRD-in -77.1, -50.07 65.87, 7.19 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 152.33 APE9-dihe-na 131.97, 174.69 APE8-dihe-in -79.42, 129.32 APE8-rot-in 300.62 APE67-dihe-in -71.2, -15.34 -47.33, -44.09 APE12-dist-in 8.737 APE11-dist-in 11.659 APE10-dist-in 5.928 APE9-dist-in 3.64 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[148, 405]] 1.0 AF-Q9Y243-K1 AGC_AKT3_HUMAN AGC 2.6e-101 344.1 1 260 260 288 289 290 292 294 177 196 200 268 270 269 271 328 316 311 310 309 308 307 306 305 226 RAC-gamma serine/threonine-protein kinase
AGC AKT3 AKT3_HUMAN AF-Q9Y243-K3A Q9Y243 140 413 479.0 No_ligand No_ligand Active DFGin 5.843 12.845 BLAminus DFGAsp-rot-in -119.93, -165.91 45.76, 60.08 208.14, 19.6 -68.89, 21.59 306.78, 94.29 -64.68, -32.82 in-in in 8.8 Saltbr-in 2.682 HRD-in -85.27, -50.05 69.08, 5.0 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.19, 155.79 APE9-dihe-na 139.4, -174.29 APE8-dihe-in -95.13, 130.97 APE8-rot-in 296.55 APE67-dihe-in -70.47, -15.66 -48.46, -45.34 APE12-dist-in 8.309 APE11-dist-in 11.671 APE10-dist-in 6.004 APE9-dist-in 3.653 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[148, 405]] 1.0 AF-Q9Y243-K3 AGC_AKT3_HUMAN AGC 2.6e-101 344.1 1 260 260 288 289 290 292 294 177 196 200 268 270 269 271 328 316 311 310 309 308 307 306 305 226 RAC-gamma serine/threonine-protein kinase
AGC CDC42BPA MRCKA_HUMAN AF-Q5VT25-K1A Q5VT25 69 351 1732.0 No_ligand No_ligand Active DFGin 6.627 14.085 BLAminus DFGAsp-rot-in -137.35, 178.83 52.57, 60.69 202.87, 23.81 -74.75, 17.34 293.19, 92.14 -61.72, -19.0 in-in in 8.934 Saltbr-in 2.688 HRD-in -76.44, -46.24 68.08, 6.85 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.21, 130.01 APE9-dihe-na 139.4, 177.82 APE8-dihe-in -74.18, 124.45 APE8-rot-in 302.09 APE67-dihe-in -66.75, -21.22 -50.16, -45.25 APE12-dist-in 10.239 APE11-dist-in 11.032 APE10-dist-in 5.325 APE9-dist-in 3.918 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[77, 343]] 1.0 AF-Q5VT25-K1 AGC_CDC42BPA_HUMAN AGC 1.1e-96 328.9 1 260 260 218 219 220 222 224 106 125 129 198 200 199 201 264 247 242 241 240 239 238 237 236 155 Serine/threonine-protein kinase MRCK alpha
AGC CDC42BPA MRCKA_HUMAN AF-Q5VT25-K3A Q5VT25 69 351 1732.0 No_ligand No_ligand Active DFGin 6.089 13.554 BLAminus DFGAsp-rot-in -140.55, 172.62 55.82, 69.24 200.22, 6.66 -78.39, 15.33 299.05, 91.36 -61.53, -17.02 in-in in 8.555 Saltbr-in 2.635 HRD-in -79.96, -45.49 66.46, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.67, 146.01 APE9-dihe-na 127.4, 168.74 APE8-dihe-in -72.01, 132.81 APE8-rot-in 288.27 APE67-dihe-in -76.54, -19.12 -51.84, -40.74 APE12-dist-in 9.879 APE11-dist-in 11.252 APE10-dist-in 5.425 APE9-dist-in 3.544 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[77, 343]] 1.0 AF-Q5VT25-K3 AGC_CDC42BPA_HUMAN AGC 1.1e-96 328.9 1 260 260 218 219 220 222 224 106 125 129 198 200 199 201 264 247 242 241 240 239 238 237 236 155 Serine/threonine-protein kinase MRCK alpha
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.536 13.389 BLAminus DFGAsp-rot-in -126.67, 169.91 71.43, 81.15 187.26, 6.44 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.635 Saltbr-in 2.748 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.511 APE11-dist-in 11.151 APE10-dist-in 6.313 APE9-dist-in 3.548 None None None XRAY 1.73 0.198 0.243 A 419 401 0 0 0 0 [[76, 342]] 1.0 4uak AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN AF-Q9Y5S2-K1A Q9Y5S2 68 350 1711.0 No_ligand No_ligand Active DFGin 6.286 13.418 BLAminus DFGAsp-rot-in -138.11, 175.86 52.03, 73.16 198.2, 19.2 -82.88, 16.9 300.82, 95.68 -61.27, -18.14 in-in in 8.67 Saltbr-in 2.619 HRD-in -80.82, -44.33 65.35, 6.41 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.32, 151.0 APE9-dihe-na 118.31, 170.33 APE8-dihe-in -66.77, 129.62 APE8-rot-in 287.64 APE67-dihe-in -77.39, -20.44 -51.73, -36.54 APE12-dist-in 9.843 APE11-dist-in 10.942 APE10-dist-in 5.188 APE9-dist-in 3.788 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[76, 342]] 1.0 AF-Q9Y5S2-K1 AGC_CDC42BPB_HUMAN AGC 1.8e-96 328.2 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN AF-Q9Y5S2-K3A Q9Y5S2 68 350 1711.0 No_ligand No_ligand Active DFGin 6.165 13.252 BLAminus DFGAsp-rot-in -140.87, 174.27 54.93, 67.41 202.11, 11.11 -77.14, 15.47 302.2, 109.63 -60.94, -17.3 in-in in 8.594 Saltbr-in 2.681 HRD-in -80.0, -45.38 64.95, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.11, 160.14 APE9-dihe-na 106.26, -177.58 APE8-dihe-in -89.7, 125.56 APE8-rot-in 303.52 APE67-dihe-in -69.05, -20.8 -47.75, -44.36 APE12-dist-in 9.53 APE11-dist-in 10.952 APE10-dist-in 5.151 APE9-dist-in 3.627 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[76, 342]] 1.0 AF-Q9Y5S2-K3 AGC_CDC42BPB_HUMAN AGC 1.8e-96 328.2 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3QFVA Q9Y5S2 2 415 1711.0 NM7:416 Type1 Active DFGin 6.652 13.483 BLAminus DFGAsp-rot-in -155.19, -177.74 51.28, 74.91 210.1, 7.48 -100.44, 20.96 290.95, 120.41 -84.8, 1.24 in-in in 8.66 Saltbr-in 3.586 HRD-in -68.56, -55.63 80.26, 2.79 in-in-in SNCiii in-in ActLoopNT-in 3.062 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.25, 145.57 APE9-dihe-na 95.66, -174.68 APE8-dihe-in -88.83, 133.9 APE8-rot-in 320.1 APE67-dihe-in -63.11, -25.9 -60.21, -35.51 APE12-dist-in 10.616 APE11-dist-in 11.198 APE10-dist-in 5.501 APE9-dist-in 4.17 None None None XRAY 2.65 0.196 0.268 A 415 395 0 0 0 0 [[76, 342]] 1.0 3qfv AGC_CDC42BPB_HUMAN AGC 6.6e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3QFVB Q9Y5S2 2 415 1711.0 NM7:416 Type1 Active DFGin 6.357 13.248 BLAminus DFGAsp-rot-in -146.98, -178.33 51.23, 77.88 197.04, -79.76 -102.57, 32.33 302.88, 111.63 -92.77, 5.32 in-in in 8.692 Saltbr-in 2.619 HRD-in -65.12, -52.57 79.81, -7.22 in-in-in SNCiii in-in ActLoopNT-in 3.139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.96, 150.13 APE9-dihe-na 114.47, 164.94 APE8-dihe-in -66.67, 141.54 APE8-rot-in 317.58 APE67-dihe-in -60.07, -38.36 -60.72, -35.72 APE12-dist-in 10.736 APE11-dist-in 11.342 APE10-dist-in 5.667 APE9-dist-in 4.087 None None None XRAY 2.65 0.196 0.268 B 415 396 0 0 0 0 [[76, 342]] 1.0 3qfv AGC_CDC42BPB_HUMAN AGC 6.6e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 4UALA Q9Y5S2 2 417 1711.0 3FV:60501 Type1 Active DFGin 6.57 13.343 BLAminus DFGAsp-rot-in -128.09, 170.47 58.99, 78.49 204.14, -10.96 -90.49, 11.57 302.61, 102.02 -65.54, -5.61 in-in in 8.675 Saltbr-in 2.909 HRD-in -76.1, -52.24 74.17, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.7, -165.94 APE9-dihe-na 97.69, -165.3 APE8-dihe-in -123.13, 127.49 APE8-rot-in 312.99 APE67-dihe-in -64.7, -21.04 -49.2, -41.29 APE12-dist-in 10.401 APE11-dist-in 10.706 APE10-dist-in 5.458 APE9-dist-in 3.725 None None None XRAY 1.71 0.206 0.236 A 419 400 5 0 0 3 [[76, 342]] 1.0 4ual AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 5OTEA Q9Y5S2 2 417 1711.0 AQE:60501 Type1 Active DFGin 6.44 13.538 BLAminus DFGAsp-rot-in -132.86, 172.8 58.15, 78.6 203.24, -11.81 -89.88, 11.87 305.96, 106.7 -64.89, -6.52 in-in in 8.637 Saltbr-in 2.717 HRD-in -76.88, -48.31 73.79, 2.14 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 152.67 APE9-dihe-na 86.33, -167.63 APE8-dihe-in -120.1, 130.3 APE8-rot-in 304.26 APE67-dihe-in -60.96, -19.55 -48.3, -43.83 APE12-dist-in 10.442 APE11-dist-in 11.319 APE10-dist-in 6.425 APE9-dist-in 3.469 None None None XRAY 1.68 0.197 0.218 A 419 404 2 0 0 0 [[76, 342]] 1.0 5ote AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 5OTFA Q9Y5S2 2 417 1711.0 AQ5:60504 Type1 Active DFGin 6.474 13.836 BLAminus DFGAsp-rot-in -138.71, 166.8 56.15, 77.62 201.3, -13.37 -87.94, 13.12 305.59, 108.27 -63.54, -12.28 in-in in 8.966 Saltbr-in 2.633 HRD-in -69.74, -49.73 69.82, 11.73 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.82, 174.96 APE9-dihe-na 90.86, 165.77 APE8-dihe-in -78.76, 136.08 APE8-rot-in 311.34 APE67-dihe-in -61.08, -29.98 -51.0, -40.22 APE12-dist-in 10.501 APE11-dist-in 10.889 APE10-dist-in 5.774 APE9-dist-in 4.003 None None None XRAY 2.0 0.201 0.227 A 419 408 0 0 0 0 [[76, 342]] 1.0 5otf AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUA Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.602 13.355 BLAminus DFGAsp-rot-in -143.03, 175.94 52.02, 80.01 192.66, 1.52 -94.23, 18.83 305.33, 99.72 -66.85, -0.48 in-in in 8.858 Saltbr-in 2.916 HRD-in -68.08, -55.01 75.95, 5.48 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.43, 163.82 APE9-dihe-na 93.99, -165.51 APE8-dihe-in -114.48, 131.1 APE8-rot-in 310.89 APE67-dihe-in -54.25, -25.55 -45.59, -49.4 APE12-dist-in 11.04 APE11-dist-in 11.04 APE10-dist-in 5.176 APE9-dist-in 3.762 None None None XRAY 2.15 0.223 0.273 A 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.4e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUB Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.7 13.42 BLAminus DFGAsp-rot-in -146.47, 178.95 50.88, 78.82 194.59, -4.77 -93.25, 17.64 304.13, 100.62 -66.46, -1.59 in-in in 8.934 Saltbr-in 2.849 HRD-in -79.08, -52.56 75.39, 5.44 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.41, 166.49 APE9-dihe-na 89.07, -163.52 APE8-dihe-in -118.0, 134.6 APE8-rot-in 310.18 APE67-dihe-in -54.07, -25.9 -51.37, -47.08 APE12-dist-in 11.06 APE11-dist-in 11.053 APE10-dist-in 5.192 APE9-dist-in 3.746 None None None XRAY 2.15 0.223 0.273 B 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.4e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPG MRCKG_HUMAN AF-Q6DT37-K1A Q6DT37 63 345 1551.0 No_ligand No_ligand Active DFGin 6.249 13.354 BLAminus DFGAsp-rot-in -136.58, 177.62 52.53, 69.39 199.75, 21.61 -81.79, 17.47 304.78, 93.89 -60.65, -18.57 in-in in 8.764 Saltbr-in 2.697 HRD-in -74.8, -49.36 68.64, -0.64 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.03, 134.36 APE9-dihe-na 135.63, 174.09 APE8-dihe-in -75.39, 129.12 APE8-rot-in 303.67 APE67-dihe-in -74.05, -21.28 -51.4, -41.32 APE12-dist-in 10.059 APE11-dist-in 11.03 APE10-dist-in 5.264 APE9-dist-in 3.729 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[71, 337]] 1.0 AF-Q6DT37-K1 AGC_CDC42BPG_HUMAN AGC 1.8e-91 311.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 258 241 236 235 234 233 232 231 230 149 Serine/threonine-protein kinase MRCK gamma
AGC CDC42BPG MRCKG_HUMAN AF-Q6DT37-K3A Q6DT37 63 345 1551.0 No_ligand No_ligand Active DFGin 6.052 13.3 BLAminus DFGAsp-rot-in -141.28, 172.37 53.37, 66.71 201.85, 7.05 -75.24, 16.17 303.15, 98.83 -61.17, -19.77 in-in in 8.565 Saltbr-in 2.619 HRD-in -82.2, -47.68 64.54, 7.21 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 148.94 APE9-dihe-na 121.6, 174.29 APE8-dihe-in -71.61, 132.51 APE8-rot-in 297.13 APE67-dihe-in -71.85, -16.71 -50.64, -43.7 APE12-dist-in 9.674 APE11-dist-in 10.915 APE10-dist-in 5.186 APE9-dist-in 3.564 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[71, 337]] 1.0 AF-Q6DT37-K3 AGC_CDC42BPG_HUMAN AGC 1.8e-91 311.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 258 241 236 235 234 233 232 231 230 149 Serine/threonine-protein kinase MRCK gamma
AGC CIT CTRO_HUMAN AF-O14578-K1A O14578 89 368 2027.0 No_ligand No_ligand Active DFGin 6.409 13.254 BLAminus DFGAsp-rot-in -133.75, 176.99 59.92, 65.89 197.73, 24.84 -78.38, 15.69 305.38, 98.39 -62.22, -18.89 in-in in 8.488 Saltbr-in 2.652 HRD-in -75.88, -45.79 66.97, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.7, 139.89 APE9-dihe-na 127.55, 176.62 APE8-dihe-in -71.67, 127.44 APE8-rot-in 288.09 APE67-dihe-in -73.05, -16.96 -48.85, -41.55 APE12-dist-in 11.105 APE11-dist-in 11.223 APE10-dist-in 5.522 APE9-dist-in 3.54 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[97, 360]] 1.0 AF-O14578-K1 AGC_CIT_HUMAN AGC 9e-83 283.3 1 260 260 238 239 240 242 244 126 145 149 218 220 219 221 285 267 262 261 260 259 258 257 256 175 Citron Rho-interacting kinase
AGC CIT CTRO_HUMAN AF-O14578-K3A O14578 89 368 2027.0 No_ligand No_ligand Active DFGin 6.268 13.112 BLAminus DFGAsp-rot-in -131.84, 178.95 60.29, 59.62 201.21, 19.96 -70.63, 9.42 310.34, 101.74 -63.63, -17.83 in-in in 8.165 Saltbr-in 2.667 HRD-in -75.16, -46.66 70.27, -11.82 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.71, 138.84 APE9-dihe-na 132.93, -179.42 APE8-dihe-in -87.72, 130.21 APE8-rot-in 296.39 APE67-dihe-in -71.65, -18.6 -46.94, -44.88 APE12-dist-in 11.406 APE11-dist-in 11.753 APE10-dist-in 5.946 APE9-dist-in 3.113 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[97, 360]] 1.0 AF-O14578-K3 AGC_CIT_HUMAN AGC 9e-83 283.3 1 260 260 238 239 240 242 244 126 145 149 218 220 219 221 285 267 262 261 260 259 258 257 256 175 Citron Rho-interacting kinase
AGC DMPK DMPK_HUMAN AF-Q09013-K1A Q09013 63 347 629.0 No_ligand No_ligand Active DFGin 6.346 13.852 BLAminus DFGAsp-rot-in -137.62, 177.74 53.65, 65.13 199.56, 22.08 -77.89, 17.17 296.72, 90.52 -60.73, -21.33 in-in in 8.815 Saltbr-in 2.648 HRD-in -80.23, -48.51 67.35, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 128.58 APE9-dihe-na 140.09, 174.97 APE8-dihe-in -73.76, 126.81 APE8-rot-in 301.78 APE67-dihe-in -67.58, -20.1 -48.89, -47.46 APE12-dist-in 10.002 APE11-dist-in 10.994 APE10-dist-in 5.275 APE9-dist-in 3.818 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[71, 339]] 1.0 AF-Q09013-K1 AGC_DMPK_HUMAN AGC 6.1e-90 306.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN AF-Q09013-K3A Q09013 63 347 629.0 No_ligand No_ligand Active DFGin 6.28 13.587 BLAminus DFGAsp-rot-in -138.65, -179.6 53.91, 53.19 203.19, 21.93 -69.94, 14.2 301.64, 92.66 -62.49, -16.23 in-in in 8.767 Saltbr-in 2.74 HRD-in -83.91, -45.62 68.98, 2.73 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.36, 130.62 APE9-dihe-na 136.22, 175.22 APE8-dihe-in -79.62, 130.97 APE8-rot-in 297.38 APE67-dihe-in -72.32, -21.96 -47.71, -46.74 APE12-dist-in 10.104 APE11-dist-in 11.131 APE10-dist-in 5.319 APE9-dist-in 3.399 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[71, 339]] 1.0 AF-Q09013-K3 AGC_DMPK_HUMAN AGC 6.1e-90 306.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5A Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.454 13.714 BLAminus DFGAsp-rot-in -135.51, 173.02 64.16, 82.57 202.64, -19.0 -103.69, 18.13 299.09, 90.62 -77.9, 10.3 in-in in 8.8 Saltbr-in 2.505 HRD-in -77.17, -55.14 72.28, 14.55 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.26, 159.56 APE9-dihe-na 91.29, 143.9 APE8-dihe-in -51.98, 129.25 APE8-rot-in 309.4 APE67-dihe-in -62.16, -18.51 -40.32, -51.73 APE12-dist-in 10.917 APE11-dist-in 10.832 APE10-dist-in 5.147 APE9-dist-in 3.422 None None None XRAY 2.8 0.198 0.244 A 412 390 4 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5B Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.584 14.066 BLAminus DFGAsp-rot-in -121.55, -178.43 55.14, 76.32 200.88, -18.1 -92.54, 18.35 300.48, 94.03 -63.79, -6.57 in-in in 8.838 Saltbr-in 2.497 HRD-in -79.22, -52.08 70.41, 5.71 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.77, 162.62 APE9-dihe-na 96.06, 164.49 APE8-dihe-in -76.33, 130.66 APE8-rot-in 327.06 APE67-dihe-in -66.1, -27.98 -47.72, -38.95 APE12-dist-in 11.28 APE11-dist-in 11.013 APE10-dist-in 5.474 APE9-dist-in 3.936 None None None XRAY 2.8 0.198 0.244 B 412 380 11 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC GRK1 GRK1_HUMAN AF-Q15835-K1A Q15835 182 463 563.0 No_ligand No_ligand Active DFGin 6.287 12.982 BLAminus DFGAsp-rot-in -136.35, -175.46 50.41, 68.56 206.49, 12.29 -84.63, 18.73 288.09, 153.13 -66.15, -19.38 in-in in 8.539 Saltbr-in 2.698 HRD-in -79.0, -46.45 64.22, 3.54 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.64, 146.23 APE9-dihe-na 128.56, 178.92 APE8-dihe-in -91.42, 131.88 APE8-rot-in 297.69 APE67-dihe-inflip 105.02, -24.11 -55.02, 126.46 APE12-dist-in 10.603 APE11-dist-in 11.278 APE10-dist-in 5.539 APE9-dist-in 3.316 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[190, 455]] 1.0 AF-Q15835-K1 AGC_GRK1_HUMAN AGC 4.9e-81 277.6 4 260 257 334 335 336 338 340 219 238 242 314 316 315 317 374 362 357 356 355 354 353 352 351 268 Rhodopsin kinase GRK1
AGC GRK1 GRK1_HUMAN AF-Q15835-K3A Q15835 182 463 563.0 No_ligand No_ligand Active DFGin 6.234 12.673 BLAminus DFGAsp-rot-in -132.6, -178.51 49.86, 63.45 203.93, 1.25 -76.42, 16.89 298.82, 166.43 -67.25, -17.86 in-in in 8.359 Saltbr-in 2.707 HRD-in -85.57, -47.78 70.01, -0.82 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.92, 145.73 APE9-dihe-na 125.2, -163.99 APE8-dihe-in -109.07, 130.14 APE8-rot-in 295.51 APE67-dihe-inflip 103.48, -23.56 -54.31, 127.87 APE12-dist-in 10.526 APE11-dist-in 11.024 APE10-dist-in 5.333 APE9-dist-in 3.034 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[190, 455]] 1.0 AF-Q15835-K3 AGC_GRK1_HUMAN AGC 4.9e-81 277.6 4 260 257 334 335 336 338 340 219 238 242 314 316 315 317 374 362 357 356 355 354 353 352 351 268 Rhodopsin kinase GRK1
AGC GRK2 ARBK1_HUMAN AF-P25098-K1A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.562 13.067 BLAminus DFGAsp-rot-in -119.78, 178.65 52.56, 73.94 202.12, 24.92 -83.8, 16.08 278.33, 71.82 -60.8, -26.56 in-in in 8.541 Saltbr-in 2.589 HRD-in -80.89, -42.45 65.72, -2.62 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.3, 128.35 APE9-dihe-na 142.96, -178.54 APE8-dihe-in -87.49, 128.15 APE8-rot-in 299.26 APE67-dihe-inflip 86.45, 0.9 -52.52, 136.47 APE12-dist-in 10.234 APE11-dist-in 12.025 APE10-dist-in 6.083 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P25098-K1 AGC_GRK2_HUMAN AGC 4.8e-78 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN AF-P25098-K3A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.32 12.853 BLAminus DFGAsp-rot-in -125.8, 178.57 52.64, 62.07 205.19, 18.18 -71.89, 17.23 286.12, 88.29 -61.97, -25.79 in-in in 8.526 Saltbr-in 2.55 HRD-in -86.05, -43.82 69.06, 3.02 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.98, 153.8 APE9-dihe-na 127.94, -163.33 APE8-dihe-in -103.05, 123.69 APE8-rot-in 298.01 APE67-dihe-inflip 89.53, 2.54 -53.74, 129.56 APE12-dist-in 9.061 APE11-dist-in 11.855 APE10-dist-in 5.951 APE9-dist-in 3.215 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P25098-K3 AGC_GRK2_HUMAN AGC 4.8e-78 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKLA P25098 31 671 689.0 SIX:702 Type1 Active DFGin 5.553 13.455 BLAminus DFGAsp-rot-in -136.15, 162.37 65.35, 90.8 183.32, 22.08 -91.1, 16.16 287.26, 80.35 -44.51, -43.27 in-in in 8.936 Saltbr-in 2.627 HRD-in -76.69, -51.69 80.53, -28.69 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.59, 119.44 APE9-dihe-na 167.03, -154.05 APE8-dihe-in -112.97, 140.97 APE8-rot-in 300.02 APE67-dihe-in -82.52, 9.1 -61.65, -35.94 APE12-dist-in 10.201 APE11-dist-in 11.742 APE10-dist-in 5.843 APE9-dist-in 3.756 S670A None None XRAY 2.15 0.184 0.228 A 642 630 0 0 0 0 [[191, 453]] 1.0 5ukl AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 4MK0A P25098 30 668 689.0 29X:60702 Type1 Active DFGin 5.022 12.557 BLAminus DFGAsp-rot-in -114.3, 159.32 62.47, 95.12 204.08, -37.37 -99.09, 26.84 314.83, 15.76 -55.23, -46.17 in-in in 8.796 Saltbr-in 3.293 HRD-in -74.82, -46.73 65.86, 15.22 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.22, 138.8 APE9-dihe-na 140.75, -169.47 APE8-dihe-in -90.2, 139.3 APE8-rot-in 300.61 APE67-dihe-inflip 101.57, -12.83 -69.61, 140.12 APE12-dist-in 10.215 APE11-dist-in 12.155 APE10-dist-in 6.419 APE9-dist-in 3.225 None None None XRAY 2.4 0.179 0.238 A 640 630 0 0 0 0 [[191, 453]] 1.0 4mk0 AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7K7LA P25098 30 668 689.0 W4D:702 Type1 Active DFGin 5.346 13.407 BLAminus DFGAsp-rot-in -120.75, 157.11 65.86, 85.74 188.79, 17.26 -89.44, 20.76 269.03, 169.7 -63.22, -26.35 in-in in 9.088 Saltbr-in 2.744 HRD-in -83.14, -50.8 72.46, -22.33 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 143.89 APE9-dihe-na 130.34, -178.78 APE8-dihe-in -87.05, 140.86 APE8-rot-in 300.91 APE67-dihe-inflip 101.09, -17.29 -67.82, 137.73 APE12-dist-in 10.803 APE11-dist-in 12.386 APE10-dist-in 6.443 APE9-dist-in 3.667 None None None XRAY 2.539 0.203 0.244 A 640 616 0 0 0 0 [[191, 453]] 1.0 7k7l AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7K7ZA P25098 30 668 689.0 W4G:701 Type1 Active DFGin 5.228 13.261 BLAminus DFGAsp-rot-in -131.21, 159.45 58.45, 84.74 193.09, -42.66 -81.51, 17.96 273.45, 160.93 -49.98, -46.53 in-in in 9.15 Saltbr-in 2.606 HRD-in -69.84, -65.83 82.28, 6.02 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 129.42 APE9-dihe-na 151.42, -156.98 APE8-dihe-in -108.77, 134.07 APE8-rot-in 292.67 APE67-dihe-inflip 104.4, -17.1 -64.98, 131.58 APE12-dist-in 12.686 APE11-dist-in 12.309 APE10-dist-in 6.485 APE9-dist-in 3.28 None None None XRAY 2.606 0.207 0.262 A 640 625 0 0 0 0 [[191, 453]] 1.0 7k7z AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 4PNKA P25098 30 668 689.0 KZQ:701 Type1 Active DFGin 5.696 13.31 BLAminus DFGAsp-rot-in -131.92, 150.67 73.23, 94.18 199.64, -36.26 -104.4, 20.24 276.38, 72.07 -49.27, -48.99 in-in in 8.869 Saltbr-in 2.892 HRD-in -75.55, -46.99 79.65, -28.55 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 151.18 APE9-dihe-na 153.42, -170.47 APE8-dihe-in -97.49, 139.43 APE8-rot-in 296.18 APE67-dihe-inflip 99.83, -0.25 -68.24, 133.65 APE12-dist-in 10.11 APE11-dist-in 11.731 APE10-dist-in 5.94 APE9-dist-in 3.597 None None None XRAY 2.56 0.194 0.259 A 689 625 0 0 0 0 [[191, 453]] 1.0 4pnk AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5WG5A P25098 30 668 689.0 ZSO:701 Type1 Active DFGin 5.451 13.01 BLAminus DFGAsp-rot-in -128.14, 171.88 56.74, 83.28 192.77, 21.75 -91.88, 32.75 279.7, 68.89 -65.05, -47.67 in-in in 8.625 Saltbr-in 2.651 HRD-in -77.29, -47.13 67.77, -1.76 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.64, 131.79 APE9-dihe-na 147.8, -171.59 APE8-dihe-in -95.05, 124.52 APE8-rot-in 297.6 APE67-dihe-inflip 97.31, -8.85 -62.05, 143.11 APE12-dist-in 10.491 APE11-dist-in 12.044 APE10-dist-in 6.193 APE9-dist-in 3.392 None None None XRAY 3.1 0.19 0.232 A 689 617 3 0 0 0 [[191, 453]] 1.0 5wg5 AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.407 13.123 BLAminus DFGAsp-rot-in -119.49, 148.71 76.08, 97.29 197.42, -12.71 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.399 Saltbr-in 2.971 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.151 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.922 APE11-dist-in 11.89 APE10-dist-in 5.931 APE9-dist-in 3.549 None None None XRAY 2.7 0.215 0.257 A 547 414 0 0 0 0 [[191, 453]] 1.0 5uuu AGC_GRK2_HUMAN AGC 3.8e-77 268.3 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK3 ARBK2_HUMAN AF-P35626-K1A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.389 12.979 BLAminus DFGAsp-rot-in -119.85, -177.05 47.66, 71.7 202.74, 28.68 -81.78, 19.84 282.66, 77.07 -60.27, -30.98 in-in in 8.444 Saltbr-in 2.574 HRD-in -79.78, -43.12 66.85, 1.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.85, 154.0 APE9-dihe-na 126.52, 172.74 APE8-dihe-in -77.57, 128.03 APE8-rot-in 302.33 APE67-dihe-inflip 86.21, -2.04 -52.74, 135.57 APE12-dist-in 9.228 APE11-dist-in 12.059 APE10-dist-in 6.147 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K1 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
AGC GRK3 ARBK2_HUMAN AF-P35626-K3A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.337 12.966 BLAminus DFGAsp-rot-in -127.84, 178.42 53.44, 63.01 205.73, 15.61 -72.34, 17.54 287.43, 91.74 -61.73, -26.86 in-in in 8.586 Saltbr-in 2.574 HRD-in -86.58, -43.9 68.67, 3.65 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 153.69 APE9-dihe-na 128.92, -164.53 APE8-dihe-in -101.52, 124.31 APE8-rot-in 298.48 APE67-dihe-inflip 88.79, 1.53 -53.76, 131.32 APE12-dist-in 9.093 APE11-dist-in 11.84 APE10-dist-in 5.923 APE9-dist-in 3.195 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K3 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
AGC GRK4 GRK4_HUMAN 4YHJA P32298 25 525 578.0 AN2:601 ATPlike Active DFGin 6.129 13.374 BLAminus DFGAsp-rot-in -118.16, -176.89 50.04, 69.58 195.65, -12.01 -89.94, 31.88 285.36, 98.48 -66.46, -45.19 in-in in 9.266 Saltbr-in 3.026 HRD-in -63.35, -45.97 74.46, -21.42 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 157.81 APE9-dihe-na 113.97, -154.87 APE8-dihe-in -108.33, 139.74 APE8-rot-in 312.15 APE67-dihe-inflip 104.58, -18.92 -61.34, 124.85 APE12-dist-in 11.453 APE11-dist-in 12.888 APE10-dist-in 6.916 APE9-dist-in 4.145 C563S,C578S None None XRAY 2.6 0.2 0.248 A 584 501 0 0 0 0 [[187, 449]] 1.0 4yhj AGC_GRK4_HUMAN AGC 8.4e-84 286.9 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN AF-P32298-K1A P32298 179 457 578.0 No_ligand No_ligand Active DFGin 6.124 12.833 BLAminus DFGAsp-rot-in -120.03, -175.56 45.08, 74.96 204.69, 22.87 -87.72, 22.25 285.66, 73.41 -59.0, -38.27 in-in in 8.768 Saltbr-in 2.66 HRD-in -81.72, -44.96 67.52, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.15, 151.54 APE9-dihe-na 127.86, 174.63 APE8-dihe-in -80.28, 134.89 APE8-rot-in 301.77 APE67-dihe-inflip 97.33, -20.86 -54.78, 131.24 APE12-dist-in 10.479 APE11-dist-in 12.253 APE10-dist-in 6.255 APE9-dist-in 3.575 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[187, 449]] 1.0 AF-P32298-K1 AGC_GRK4_HUMAN AGC 9e-85 289.8 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN AF-P32298-K3A P32298 179 457 578.0 No_ligand No_ligand Active DFGin 6.099 12.768 BLAminus DFGAsp-rot-in -126.56, 178.75 48.35, 61.02 204.87, 23.2 -72.83, 20.71 294.75, 76.46 -64.12, -27.65 in-in in 8.885 Saltbr-in 2.619 HRD-in -85.16, -47.19 67.94, 0.45 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 150.99 APE9-dihe-na 125.92, -171.45 APE8-dihe-in -98.43, 134.52 APE8-rot-in 298.92 APE67-dihe-inflip 98.38, -17.84 -56.69, 129.66 APE12-dist-in 10.2 APE11-dist-in 11.857 APE10-dist-in 5.872 APE9-dist-in 3.235 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[187, 449]] 1.0 AF-P32298-K3 AGC_GRK4_HUMAN AGC 9e-85 289.8 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus DFGAsp-rot-in -123.04, 159.77 67.48, 80.75 208.15, -7.31 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus DFGAsp-rot-in -123.04, 167.6 79.98, 56.79 199.25, -25.13 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN AF-P34947-K3A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 6.022 12.099 BLAminus DFGAsp-rot-in -130.04, 178.69 50.56, 62.08 202.36, 7.28 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.543 Saltbr-in 2.615 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.541 APE11-dist-in 11.976 APE10-dist-in 5.961 APE9-dist-in 3.312 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K3 AGC_GRK5_HUMAN AGC 6.2e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKQA P34947 25 542 590.0 No_ligand No_ligand Active DFGin 6.036 12.85 BLAminus DFGAsp-rot-in -128.35, 170.36 62.76, 74.57 191.5, -18.84 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.106 Saltbr-in 2.933 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.779 APE11-dist-in 12.023 APE10-dist-in 6.163 APE9-dist-in 4.116 D311N None None XRAY 2.7 0.239 0.294 A 597 490 11 0 0 0 [[186, 448]] 1.0 9ckq AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAPA P34947 25 542 590.0 W2T:601 Type1 Active DFGin 5.952 12.669 BLAminus DFGAsp-rot-in -132.18, -179.7 52.11, 79.03 188.79, 1.81 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.319 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.242 APE11-dist-in 12.329 APE10-dist-in 6.498 APE9-dist-in 4.083 D311N None None XRAY 2.5 0.229 0.267 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uap AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus DFGAsp-rot-in -128.67, 172.15 57.35, 77.75 187.2, 1.77 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRGA P34947 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.888 12.744 BLAminus DFGAsp-rot-in -127.15, 171.02 61.76, 75.85 189.75, -1.48 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.043 Saltbr-in 2.346 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.77 APE11-dist-in 12.073 APE10-dist-in 6.219 APE9-dist-in 4.083 D311N None None XRAY 2.7 0.242 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brg AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRHA P34947 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.213 12.998 BLAminus DFGAsp-rot-in -137.89, -178.33 53.87, 65.42 189.34, 1.43 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.364 Saltbr-in 2.788 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.364 APE11-dist-in 12.068 APE10-dist-in 6.136 APE9-dist-in 4.119 D311N None None XRAY 3.69 0.2 0.244 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brh AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRMA P34947 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.93 12.32 BLAminus DFGAsp-rot-in -129.54, 170.53 64.08, 75.97 187.97, -0.6 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.627 Saltbr-in 2.58 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.803 APE11-dist-in 12.059 APE10-dist-in 6.213 APE9-dist-in 4.157 D311N None None XRAY 2.73 0.234 0.278 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brm AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRNA P34947 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.902 12.725 BLAminus DFGAsp-rot-in -139.33, 159.94 74.16, 72.44 193.95, -6.51 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.993 Saltbr-in 2.439 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.809 APE11-dist-in 11.996 APE10-dist-in 6.094 APE9-dist-in 4.274 D311N None None XRAY 2.9 0.209 0.256 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brn AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BROA P34947 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.964 12.572 BLAminus DFGAsp-rot-in -128.27, -178.6 50.36, 73.78 190.25, -7.35 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.906 Saltbr-in 2.39 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.277 APE11-dist-in 12.337 APE10-dist-in 6.406 APE9-dist-in 4.05 D311N None None XRAY 2.8 0.221 0.271 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bro AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKPA P34947 1 542 590.0 SGV:602 Type1 Active DFGin 5.386 11.98 BLAminus DFGAsp-rot-in -132.87, 164.94 63.45, 71.08 186.35, -6.85 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.975 Saltbr-in 3.569 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.27 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.034 APE11-dist-in 12.223 APE10-dist-in 6.349 APE9-dist-in 4.192 D311N None None XRAY 2.6 0.236 0.27 A 598 538 0 0 0 0 [[186, 448]] 1.0 9ckp AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.207 13.284 BLAminus DFGAsp-rot-in -133.82, 164.79 58.79, 76.03 188.37, 11.14 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.341 Saltbr-in 3.219 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.478 APE11-dist-in 11.834 APE10-dist-in 6.083 APE9-dist-in 3.906 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576 495 0 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.09 13.146 BLAminus DFGAsp-rot-in -128.37, 163.87 55.35, 87.14 186.91, 8.51 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.231 Saltbr-in 2.439 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.477 APE11-dist-in 11.872 APE10-dist-in 6.167 APE9-dist-in 3.71 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576 492 5 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOA P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.423 12.986 BLAminus DFGAsp-rot-in -150.32, 176.66 46.57, 93.99 184.14, 20.15 -112.64, 27.92 269.12, 56.38 -53.19, -36.92 in-in in 8.492 Saltbr-in 3.133 HRD-in -67.42, -53.58 67.41, 17.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.58, 145.08 APE9-dihe-na 153.72, -154.4 APE8-dihe-in -119.63, 125.01 APE8-rot-in 309.24 APE67-dihe-inflip 99.19, -30.43 -48.0, 129.76 APE12-dist-in 10.102 APE11-dist-in 11.881 APE10-dist-in 6.152 APE9-dist-in 3.985 None None None XRAY 2.92 0.222 0.253 A 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOB P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.469 12.921 BLAminus DFGAsp-rot-in -147.57, -176.88 49.48, 66.09 192.64, 45.89 -89.42, 43.68 283.74, 78.16 -61.9, -48.01 in-in in 8.429 Saltbr-in 2.859 HRD-in -67.89, -44.49 63.77, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 138.67 APE9-dihe-na 143.94, 179.93 APE8-dihe-in -100.37, 135.53 APE8-rot-in 311.67 APE67-dihe-inflip 96.9, -39.59 -38.27, 126.0 APE12-dist-in 10.148 APE11-dist-in 11.731 APE10-dist-in 5.96 APE9-dist-in 3.734 None None None XRAY 2.92 0.222 0.253 B 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN AF-P43250-K1A P43250 178 456 576.0 No_ligand No_ligand Active DFGin 6.216 12.749 BLAminus DFGAsp-rot-in -123.11, -178.58 47.67, 74.06 201.73, 22.12 -87.65, 23.59 291.93, 77.77 -58.68, -35.83 in-in in 8.712 Saltbr-in 2.665 HRD-in -82.84, -44.36 66.32, 2.28 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.32, 157.5 APE9-dihe-na 121.0, 172.74 APE8-dihe-in -78.3, 135.32 APE8-rot-in 301.62 APE67-dihe-inflip 93.32, -20.35 -55.72, 131.85 APE12-dist-in 10.366 APE11-dist-in 12.137 APE10-dist-in 6.139 APE9-dist-in 3.49 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P43250-K1 AGC_GRK6_HUMAN AGC 2.3e-86 295.0 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN AF-P43250-K3A P43250 178 456 576.0 No_ligand No_ligand Active DFGin 6.045 12.282 BLAminus DFGAsp-rot-in -130.79, 178.36 51.08, 64.04 203.4, 6.87 -74.31, 18.83 302.42, 178.07 -60.87, -31.76 in-in in 8.624 Saltbr-in 2.619 HRD-in -87.79, -47.34 67.55, 3.73 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 159.69 APE9-dihe-na 109.39, -175.73 APE8-dihe-in -92.28, 133.79 APE8-rot-in 298.55 APE67-dihe-inflip 96.49, -17.7 -57.25, 129.59 APE12-dist-in 10.525 APE11-dist-in 11.952 APE10-dist-in 5.989 APE9-dist-in 3.192 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P43250-K3 AGC_GRK6_HUMAN AGC 2.3e-86 295.0 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK7 GRK7_HUMAN AF-Q8WTQ7-K1A Q8WTQ7 183 462 553.0 No_ligand No_ligand Active DFGin 5.929 12.613 BLAminus DFGAsp-rot-in -133.31, 179.18 49.9, 64.37 204.5, 25.45 -76.28, 16.87 298.16, 175.08 -59.65, -30.13 in-in in 8.672 Saltbr-in 2.652 HRD-in -76.82, -43.16 65.03, -5.02 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.38, 151.36 APE9-dihe-na 130.52, 169.53 APE8-dihe-in -83.21, 132.57 APE8-rot-in 300.08 APE67-dihe-inflip 93.05, -16.2 -55.98, 134.31 APE12-dist-in 9.402 APE11-dist-in 11.255 APE10-dist-in 5.521 APE9-dist-in 3.339 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[191, 454]] 1.0 AF-Q8WTQ7-K1 AGC_GRK7_HUMAN AGC 7.5e-77 263.9 1 260 260 333 334 335 337 339 220 239 243 313 315 314 316 373 360 355 354 353 352 351 350 349 269 Rhodopsin kinase GRK7
AGC GRK7 GRK7_HUMAN AF-Q8WTQ7-K3A Q8WTQ7 183 462 553.0 No_ligand No_ligand Active DFGin 6.049 12.227 BLAminus DFGAsp-rot-in -140.12, -175.95 46.19, 59.72 201.36, 9.33 -72.96, 14.71 305.72, 3.12 -61.03, -26.32 in-in in 8.426 Saltbr-in 2.648 HRD-in -81.75, -42.27 66.36, -4.03 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.45, 154.07 APE9-dihe-na 122.89, 177.55 APE8-dihe-in -94.77, 134.12 APE8-rot-in 298.37 APE67-dihe-inflip 101.79, -16.54 -61.18, 130.51 APE12-dist-in 9.597 APE11-dist-in 11.158 APE10-dist-in 5.385 APE9-dist-in 3.096 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[191, 454]] 1.0 AF-Q8WTQ7-K3 AGC_GRK7_HUMAN AGC 7.5e-77 263.9 1 260 260 333 334 335 337 339 220 239 243 313 315 314 316 373 360 355 354 353 352 351 350 349 269 Rhodopsin kinase GRK7
AGC LATS1 LATS1_HUMAN AF-O95835-K1A O95835 697 1018 1130.0 No_ligand No_ligand Active DFGin 6.448 13.636 BLAminus DFGAsp-rot-in -143.35, 177.8 55.65, 59.96 198.83, 24.33 -76.33, 19.85 303.31, 93.61 -60.54, -23.3 in-in in 8.715 Saltbr-in 2.589 HRD-in -76.01, -44.62 64.86, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 152.9 APE9-dihe-na 115.97, 164.18 APE8-dihe-in -69.17, 126.81 APE8-rot-in 291.41 APE67-dihe-in -73.93, -24.48 -53.79, -30.18 APE12-dist-in 8.378 APE11-dist-in 11.6 APE10-dist-in 5.68 APE9-dist-in 4.0 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[705, 1010]] 1.0 AF-O95835-K1 AGC_LATS1_HUMAN AGC 6e-99 336.3 1 260 260 845 846 847 849 851 734 753 757 825 827 826 828 932 920 915 914 913 912 911 910 909 783 Serine/threonine-protein kinase LATS1
AGC LATS1 LATS1_HUMAN AF-O95835-K3A O95835 697 1018 1130.0 No_ligand No_ligand Active DFGin 6.258 13.477 BLAminus DFGAsp-rot-in -141.89, 179.41 57.95, 56.46 204.61, 21.82 -67.19, 12.5 305.54, 96.31 -65.12, -18.55 in-in in 8.603 Saltbr-in 2.598 HRD-in -72.7, -50.58 67.96, -2.1 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.44, 160.32 APE9-dihe-na 110.94, 162.86 APE8-dihe-in -79.18, 131.32 APE8-rot-in 297.15 APE67-dihe-in -76.19, -23.32 -55.25, -28.73 APE12-dist-in 8.616 APE11-dist-in 11.521 APE10-dist-in 5.689 APE9-dist-in 3.222 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[705, 1010]] 1.0 AF-O95835-K3 AGC_LATS1_HUMAN AGC 6e-99 336.3 1 260 260 845 846 847 849 851 734 753 757 825 827 826 828 932 920 915 914 913 912 911 910 909 783 Serine/threonine-protein kinase LATS1
AGC LATS2 LATS2_HUMAN AF-Q9NRM7-K1A Q9NRM7 660 981 1088.0 No_ligand No_ligand Active DFGin 6.524 13.733 BLAminus DFGAsp-rot-in -135.12, -176.38 50.42, 56.34 205.74, 26.89 -69.48, 13.51 299.9, 82.84 -67.51, -8.19 in-in in 8.828 Saltbr-in 2.61 HRD-in -75.89, -48.73 67.39, 3.63 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.49, 167.28 APE9-dihe-na 102.76, 163.55 APE8-dihe-in -82.71, 133.67 APE8-rot-in 300.06 APE67-dihe-in -76.79, -28.01 -54.69, -30.21 APE12-dist-in 8.514 APE11-dist-in 11.63 APE10-dist-in 5.753 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[668, 973]] 1.0 AF-Q9NRM7-K1 AGC_LATS2_HUMAN AGC 1.2e-99 338.6 1 260 260 808 809 810 812 814 697 716 720 788 790 789 791 895 883 878 877 876 875 874 873 872 746 Serine/threonine-protein kinase LATS2
AGC LATS2 LATS2_HUMAN AF-Q9NRM7-K3A Q9NRM7 660 981 1088.0 No_ligand No_ligand Active DFGin 6.107 13.541 BLAminus DFGAsp-rot-in -140.84, -177.37 57.32, 57.14 202.07, 20.36 -69.85, 9.28 305.0, 103.31 -63.54, -18.57 in-in in 8.623 Saltbr-in 2.628 HRD-in -73.99, -51.28 68.37, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.94, 158.65 APE9-dihe-na 113.61, 162.45 APE8-dihe-in -79.33, 131.36 APE8-rot-in 297.59 APE67-dihe-in -73.0, -25.22 -54.12, -32.61 APE12-dist-in 8.591 APE11-dist-in 11.606 APE10-dist-in 5.771 APE9-dist-in 3.222 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[668, 973]] 1.0 AF-Q9NRM7-K3 AGC_LATS2_HUMAN AGC 1.2e-99 338.6 1 260 260 808 809 810 812 814 697 716 720 788 790 789 791 895 883 878 877 876 875 874 873 872 746 Serine/threonine-protein kinase LATS2
AGC MAST1 MAST1_HUMAN AF-Q9Y2H9-K1A Q9Y2H9 366 655 1570.0 No_ligand No_ligand Active DFGin 6.618 13.248 BLAminus DFGAsp-rot-in -138.58, -179.67 61.91, 62.13 204.55, 14.92 -75.14, 16.43 307.86, 107.52 -58.73, -26.5 in-in in 8.571 Saltbr-in 2.666 HRD-in -71.62, -49.4 68.88, -11.12 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.19, 150.52 APE9-dihe-na 122.98, 175.51 APE8-dihe-in -83.39, 115.94 APE8-rot-in 306.22 APE67-dihe-in -66.34, -22.78 -46.59, -39.59 APE12-dist-in 11.831 APE11-dist-in 12.441 APE10-dist-in 6.64 APE9-dist-in 4.145 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[374, 647]] 1.0 AF-Q9Y2H9-K1 AGC_MAST1_HUMAN AGC 6.3e-97 329.7 1 260 260 514 515 516 518 520 403 422 426 494 496 495 497 569 557 552 551 550 549 548 547 546 452 Microtubule-associated serine/threonine-protein kinase 1
AGC MAST1 MAST1_HUMAN AF-Q9Y2H9-K3A Q9Y2H9 366 655 1570.0 No_ligand No_ligand Active DFGin 6.179 13.387 BLAminus DFGAsp-rot-in -139.34, -179.61 56.59, 78.0 202.65, 4.73 -84.65, 19.65 302.87, 97.34 -64.99, -20.16 in-in in 8.473 Saltbr-in 2.607 HRD-in -75.61, -48.95 68.43, -6.75 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.99, 146.81 APE9-dihe-na 128.23, 179.36 APE8-dihe-in -77.45, 118.48 APE8-rot-in 290.11 APE67-dihe-in -64.73, -19.93 -48.18, -41.38 APE12-dist-in 11.728 APE11-dist-in 12.091 APE10-dist-in 6.665 APE9-dist-in 4.485 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[374, 647]] 1.0 AF-Q9Y2H9-K3 AGC_MAST1_HUMAN AGC 6.3e-97 329.7 1 260 260 514 515 516 518 520 403 422 426 494 496 495 497 569 557 552 551 550 549 548 547 546 452 Microtubule-associated serine/threonine-protein kinase 1
AGC MAST2 MAST2_HUMAN AF-Q6P0Q8-K1A Q6P0Q8 504 793 1798.0 No_ligand No_ligand Active DFGin 6.411 13.36 BLAminus DFGAsp-rot-in -134.48, 176.64 63.48, 68.04 204.67, 2.63 -78.49, 16.62 307.28, 103.65 -60.72, -22.41 in-in in 8.662 Saltbr-in 2.64 HRD-in -71.43, -51.38 68.67, -7.82 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.91, 149.43 APE9-dihe-na 128.65, -177.44 APE8-dihe-in -86.63, 114.88 APE8-rot-in 306.21 APE67-dihe-in -65.83, -23.52 -47.09, -39.32 APE12-dist-in 12.138 APE11-dist-in 12.568 APE10-dist-in 6.944 APE9-dist-in 4.246 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[512, 785]] 1.0 AF-Q6P0Q8-K1 AGC_MAST2_HUMAN AGC 7e-98 332.8 1 260 260 652 653 654 656 658 541 560 564 632 634 633 635 707 695 690 689 688 687 686 685 684 590 Microtubule-associated serine/threonine-protein kinase 2
AGC MAST2 MAST2_HUMAN AF-Q6P0Q8-K3A Q6P0Q8 504 793 1798.0 No_ligand No_ligand Active DFGin 6.104 13.474 BLAminus DFGAsp-rot-in -140.2, -179.55 56.73, 79.38 203.67, 1.2 -84.63, 19.96 302.1, 96.79 -64.67, -19.66 in-in in 8.476 Saltbr-in 2.603 HRD-in -72.34, -47.12 71.88, -13.41 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.18, 149.37 APE9-dihe-na 125.46, -175.09 APE8-dihe-in -86.05, 115.5 APE8-rot-in 308.38 APE67-dihe-in -64.49, -22.71 -48.28, -41.41 APE12-dist-in 11.856 APE11-dist-in 12.184 APE10-dist-in 6.823 APE9-dist-in 4.643 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[512, 785]] 1.0 AF-Q6P0Q8-K3 AGC_MAST2_HUMAN AGC 7e-98 332.8 1 260 260 652 653 654 656 658 541 560 564 632 634 633 635 707 695 690 689 688 687 686 685 684 590 Microtubule-associated serine/threonine-protein kinase 2
AGC MAST3 MAST3_HUMAN AF-O60307-K1A O60307 359 648 1309.0 No_ligand No_ligand Active DFGin 6.522 13.444 BLAminus DFGAsp-rot-in -138.03, 178.79 62.24, 64.88 204.01, 9.36 -76.46, 17.82 304.34, 93.51 -60.68, -21.95 in-in in 8.441 Saltbr-in 2.596 HRD-in -71.01, -52.26 70.35, -7.1 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.85, 149.66 APE9-dihe-na 122.8, 176.45 APE8-dihe-in -83.11, 114.61 APE8-rot-in 306.68 APE67-dihe-in -65.58, -21.81 -46.47, -40.36 APE12-dist-in 11.762 APE11-dist-in 12.28 APE10-dist-in 6.582 APE9-dist-in 4.246 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[367, 640]] 1.0 AF-O60307-K1 AGC_MAST3_HUMAN AGC 1.4e-98 335.1 1 260 260 507 508 509 511 513 396 415 419 487 489 488 490 562 550 545 544 543 542 541 540 539 445 Microtubule-associated serine/threonine-protein kinase 3
AGC MAST3 MAST3_HUMAN AF-O60307-K3A O60307 359 648 1309.0 No_ligand No_ligand Active DFGin 6.18 13.44 BLAminus DFGAsp-rot-in -138.61, 179.42 58.85, 73.13 203.99, 5.7 -80.23, 17.38 301.73, 96.41 -64.4, -20.11 in-in in 8.487 Saltbr-in 2.617 HRD-in -73.93, -52.53 71.51, -3.81 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 146.32 APE9-dihe-na 130.74, -178.05 APE8-dihe-in -84.77, 114.43 APE8-rot-in 307.72 APE67-dihe-in -65.31, -20.3 -48.45, -40.32 APE12-dist-in 11.628 APE11-dist-in 12.043 APE10-dist-in 6.588 APE9-dist-in 4.482 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[367, 640]] 1.0 AF-O60307-K3 AGC_MAST3_HUMAN AGC 1.4e-98 335.1 1 260 260 507 508 509 511 513 396 415 419 487 489 488 490 562 550 545 544 543 542 541 540 539 445 Microtubule-associated serine/threonine-protein kinase 3
AGC MAST4 MAST4_HUMAN AF-O15021-K1A O15021 562 851 2623.0 No_ligand No_ligand Active DFGin 6.44 13.459 BLAminus DFGAsp-rot-in -137.47, 177.13 60.94, 67.65 205.24, -2.06 -78.32, 16.66 306.06, 103.66 -61.37, -20.77 in-in in 8.622 Saltbr-in 2.607 HRD-in -72.62, -50.14 65.81, 7.35 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.82, 155.64 APE9-dihe-na 121.63, -177.08 APE8-dihe-in -87.04, 117.87 APE8-rot-in 305.8 APE67-dihe-in -65.95, -21.55 -46.81, -39.91 APE12-dist-in 10.092 APE11-dist-in 12.316 APE10-dist-in 6.615 APE9-dist-in 3.944 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[570, 843]] 1.0 AF-O15021-K1 AGC_MAST4_HUMAN AGC 4.8e-98 333.3 1 260 260 710 711 712 714 716 599 618 622 690 692 691 693 765 753 748 747 746 745 744 743 742 648 Microtubule-associated serine/threonine-protein kinase 4
AGC MAST4 MAST4_HUMAN AF-O15021-K3A O15021 562 851 2623.0 No_ligand No_ligand Active DFGin 6.237 13.537 BLAminus DFGAsp-rot-in -139.76, -179.31 59.32, 69.49 204.87, 4.42 -78.15, 16.78 302.9, 94.69 -64.85, -19.65 in-in in 8.563 Saltbr-in 2.646 HRD-in -73.74, -50.47 69.74, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.96, 155.78 APE9-dihe-na 123.92, -173.73 APE8-dihe-in -85.8, 119.22 APE8-rot-in 305.81 APE67-dihe-in -64.26, -20.07 -48.25, -42.01 APE12-dist-in 9.202 APE11-dist-in 11.969 APE10-dist-in 6.548 APE9-dist-in 4.0 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[570, 843]] 1.0 AF-O15021-K3 AGC_MAST4_HUMAN AGC 4.8e-98 333.3 1 260 260 710 711 712 714 716 599 618 622 690 692 691 693 765 753 748 747 746 745 744 743 742 648 Microtubule-associated serine/threonine-protein kinase 4
AGC MASTL GWL_HUMAN AF-Q96GX5-K1A Q96GX5 27 843 879.0 No_ligand No_ligand Active DFGin 6.511 14.249 BLAminus DFGAsp-rot-in -136.98, 175.5 52.45, 59.28 206.14, 9.37 -63.96, 15.13 300.56, 93.34 -53.91, -47.49 in-in in 8.776 Saltbr-in 2.642 HRD-in -73.64, -43.72 60.71, -18.09 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.26, 121.64 APE9-dihe-na 143.48, 174.34 APE8-dihe-in -74.8, 126.47 APE8-rot-in 296.06 APE67-dihe-in -71.28, -23.69 -46.57, -43.27 APE12-dist-in 11.456 APE11-dist-in 12.048 APE10-dist-in 6.356 APE9-dist-in 5.035 None None None AF2 -1.0 1.0 1.0 A 817 817 0 0 0 0 [[35, 835]] 1.0 AF-Q96GX5-K1 AGC_MASTL_HUMAN AGC 9.5e-130 437.3 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 748 743 742 741 740 739 738 737 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN AF-Q96GX5-K3A Q96GX5 27 843 879.0 No_ligand No_ligand Active DFGin 5.887 14.65 BLAminus DFGAsp-rot-in -143.15, -179.72 55.04, 67.18 203.9, 0.69 -81.13, 21.34 288.66, 83.06 -63.08, -28.24 in-in in 8.238 Saltbr-in 2.67 HRD-in -73.76, -46.46 67.61, -17.09 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.57, 127.46 APE9-dihe-na 155.7, -179.82 APE8-dihe-in -89.49, 123.19 APE8-rot-in 308.85 APE67-dihe-in -65.53, -23.25 -48.82, -46.12 APE12-dist-in 11.356 APE11-dist-in 11.666 APE10-dist-in 6.303 APE9-dist-in 5.128 None None None AF2 -1.0 1.0 1.0 A 817 817 0 0 0 0 [[35, 835]] 1.0 AF-Q96GX5-K3 AGC_MASTL_HUMAN AGC 9.5e-130 437.3 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 748 743 742 741 740 739 738 737 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.619 15.095 BLAminus DFGAsp-rot-in -141.33, -175.84 82.91, 67.67 191.68, 17.83 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.673 Saltbr-in 2.575 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.868 APE11-dist-in 12.869 APE10-dist-in 7.268 APE9-dist-in 4.745 S241A None None XRAY 1.95 0.186 0.23 A 310 288 0 0 0 0 [[82, 342]] 1.0 2biy AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.486 14.833 BLAminus DFGAsp-rot-in -136.91, -178.17 71.81, 74.55 202.23, 18.32 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.421 Saltbr-in 3.159 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.409 APE11-dist-in 10.582 APE10-dist-in 4.926 APE9-dist-in 3.479 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311 280 4 0 0 4 [[82, 342]] 1.0 3hrc AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.548 14.998 BLAminus DFGAsp-rot-in -136.55, -175.99 74.63, 72.8 201.28, 22.14 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.52 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.281 APE11-dist-in 10.502 APE10-dist-in 4.943 APE9-dist-in 3.569 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311 284 0 0 0 0 [[82, 342]] 1.0 4rrv AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.303 14.998 BLAminus DFGAsp-rot-in -144.92, -168.82 66.06, 77.78 194.2, -10.21 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.158 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.907 APE11-dist-in 10.671 APE10-dist-in 5.166 APE9-dist-in 3.705 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.328 14.55 BLAminus DFGAsp-rot-in -137.23, -179.71 80.14, 74.16 185.74, 13.47 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.274 Saltbr-in 3.302 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.872 APE11-dist-in 11.011 APE10-dist-in 5.375 APE9-dist-in 3.787 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.391 14.608 BLAminus DFGAsp-rot-in -132.15, -176.81 71.98, 84.02 194.29, 22.96 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.304 Saltbr-in 3.087 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.652 APE11-dist-in 10.863 APE10-dist-in 5.123 APE9-dist-in 3.645 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.334 14.433 BLAminus DFGAsp-rot-in -146.99, -174.22 74.22, 81.56 195.88, 5.87 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.304 Saltbr-in 3.252 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.228 APE11-dist-in 10.891 APE10-dist-in 5.348 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.551 14.867 BLAminus DFGAsp-rot-in -136.23, -174.98 70.54, 70.07 200.1, -11.41 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.252 Saltbr-in 2.643 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.163 APE11-dist-in 10.524 APE10-dist-in 4.979 APE9-dist-in 3.527 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311 280 5 0 0 0 [[82, 342]] 1.0 4ct2 AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.429 14.7 BLAminus DFGAsp-rot-in -133.69, -177.11 74.21, 73.9 195.15, 21.67 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.346 Saltbr-in 2.667 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.352 APE11-dist-in 10.498 APE10-dist-in 4.91 APE9-dist-in 3.542 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310 284 0 0 0 0 [[82, 342]] 1.0 5mrd AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.514 14.784 BLAminus DFGAsp-rot-in -133.77, -176.11 75.25, 77.12 200.44, 30.19 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.387 Saltbr-in 2.701 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.351 APE11-dist-in 10.546 APE10-dist-in 4.867 APE9-dist-in 3.481 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311 285 0 0 0 0 [[82, 342]] 1.0 3hrf AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.512 14.757 BLAminus DFGAsp-rot-in -135.73, -177.17 74.25, 74.67 196.89, 18.2 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.319 Saltbr-in 2.864 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.447 APE10-dist-in 4.873 APE9-dist-in 3.509 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a06 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus DFGAsp-rot-in -134.84, 177.25 78.73, 76.19 221.06, -58.96 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus DFGAsp-rot-in -137.24, -178.23 68.96, 84.69 188.02, 9.8 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.576 Saltbr-in 2.864 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.653 APE11-dist-in 10.852 APE10-dist-in 5.075 APE9-dist-in 3.586 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311 287 5 0 0 5 [[82, 342]] 1.0 4aw1 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.461 14.786 BLAminus DFGAsp-rot-in -139.06, -177.03 75.27, 72.83 204.82, 14.94 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.464 Saltbr-in 2.941 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.244 APE11-dist-in 10.466 APE10-dist-in 4.918 APE9-dist-in 3.544 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311 286 0 0 0 0 [[82, 342]] 1.0 4rqk AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.492 14.954 BLAminus DFGAsp-rot-in -139.41, -174.88 74.87, 69.78 197.41, 11.79 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.256 Saltbr-in 2.772 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.253 APE11-dist-in 10.488 APE10-dist-in 4.969 APE9-dist-in 3.513 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311 289 0 0 0 0 [[82, 342]] 1.0 4rqv AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.005 BLAminus DFGAsp-rot-in -134.78, 179.9 79.12, 70.17 202.31, 18.74 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.588 Saltbr-in 2.631 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.45 APE11-dist-in 10.558 APE10-dist-in 4.984 APE9-dist-in 3.553 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311 287 0 0 0 0 [[82, 342]] 1.0 5lvo AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.513 14.988 BLAminus DFGAsp-rot-in -138.47, -176.21 74.83, 73.76 201.91, 22.08 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.442 Saltbr-in 2.922 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.372 APE11-dist-in 10.575 APE10-dist-in 4.947 APE9-dist-in 3.545 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310 289 0 0 0 0 [[82, 342]] 1.0 4xx9 AGC_PDPK1_HUMAN AGC 7e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.655 14.752 BLAminus DFGAsp-rot-in -135.35, -178.9 76.01, 72.4 205.56, 22.7 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.621 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.322 APE11-dist-in 10.427 APE10-dist-in 4.998 APE9-dist-in 3.582 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a07 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 8DQTA O15530 70 359 556.0 U35:401,U35:402,U35:403 Allosteric,Allosteric,Allosteric Active DFGin 6.539 15.228 BLAminus DFGAsp-rot-in -137.99, -177.67 76.39, 75.41 195.07, 13.78 -107.03, 7.63 286.75, 95.91 -68.77, -18.63 in-in in 8.557 Saltbr-in 2.907 HRD-in -74.31, -48.93 74.07, -13.37 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 161.34 APE9-dihe-na 132.87, -165.96 APE8-dihe-in -131.33, 133.45 APE8-rot-in 295.53 APE67-dihe-in -61.71, -24.62 -51.87, -45.17 APE12-dist-in 7.252 APE11-dist-in 10.434 APE10-dist-in 4.909 APE9-dist-in 3.591 Y288G,Q292A SEP241 SEP241 XRAY 1.31 0.2 0.224 A 311 290 0 0 0 0 [[82, 342]] 1.0 8dqt AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3OTUA O15530 77 359 556.0 J30:1,BI4:360 Allosteric,Type1.5_Front Active DFGin 6.407 14.986 BLAminus DFGAsp-rot-in -147.19, -166.49 62.44, 61.65 193.06, 25.86 -95.64, 10.19 290.91, 105.88 -63.28, -24.6 in-in in 8.37 Saltbr-in 3.337 HRD-in -67.23, -53.13 82.11, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.97, 157.81 APE9-dihe-na 151.4, -176.81 APE8-dihe-in -123.26, 126.19 APE8-rot-in 294.94 APE67-dihe-in -53.95, -30.51 -40.25, -53.87 APE12-dist-in 7.712 APE11-dist-in 10.329 APE10-dist-in 5.244 APE9-dist-in 4.13 T148C SEP241 SEP241 XRAY 2.101 0.197 0.24 A 316 277 6 0 0 5 [[82, 342]] 1.0 3otu AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN AF-O15530-K1A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.307 14.752 BLAminus DFGAsp-rot-in -134.14, -175.03 67.73, 56.76 194.33, 25.44 -81.0, 7.09 290.02, 100.1 -62.73, -31.75 in-in in 8.479 Saltbr-in 2.692 HRD-in -71.22, -49.98 68.85, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 160.45 APE9-dihe-na 125.82, -178.56 APE8-dihe-in -110.7, 135.78 APE8-rot-in 301.58 APE67-dihe-in -71.92, -18.9 -54.44, -36.21 APE12-dist-in 7.478 APE11-dist-in 10.746 APE10-dist-in 5.036 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[82, 342]] 1.0 AF-O15530-K1 AGC_PDPK1_HUMAN AGC 8.6e-85 289.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN AF-O15530-K3A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.023 14.647 BLAminus DFGAsp-rot-in -139.54, -179.29 63.97, 66.91 201.03, -4.77 -82.88, 11.22 294.97, 97.73 -59.7, -35.74 in-in in 8.729 Saltbr-in 2.655 HRD-in -73.34, -47.9 67.59, -9.95 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 143.7 APE9-dihe-na 124.83, 164.09 APE8-dihe-in -82.81, 130.45 APE8-rot-in 291.03 APE67-dihe-in -71.92, -16.19 -51.02, -35.4 APE12-dist-in 8.387 APE11-dist-in 11.06 APE10-dist-in 5.29 APE9-dist-in 4.362 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[82, 342]] 1.0 AF-O15530-K3 AGC_PDPK1_HUMAN AGC 8.6e-85 289.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3SC1A O15530 73 359 556.0 3S1:900 Type1 Active DFGin 6.433 14.115 BLAminus DFGAsp-rot-in -125.85, 175.62 82.13, 80.63 188.87, 73.98 -113.39, 8.45 290.85, 87.77 -53.07, -47.22 in-in in 8.708 Saltbr-in 3.216 HRD-in -72.93, -48.81 80.48, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.12, -172.48 APE9-dihe-na 115.93, 147.74 APE8-dihe-in -93.61, 137.68 APE8-rot-in 299.7 APE67-dihe-in -55.26, -32.91 -54.79, -48.8 APE12-dist-in 8.739 APE11-dist-in 10.606 APE10-dist-in 5.411 APE9-dist-in 3.986 None SEP241 SEP241 XRAY 2.7 0.2 0.237 A 311 279 8 0 0 8 [[82, 342]] 1.0 3sc1 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3RCJA O15530 77 358 556.0 3RC:0 Type1 Active DFGin 6.55 14.392 BLAminus DFGAsp-rot-in -128.99, -167.62 59.76, 67.13 209.12, -1.28 -93.27, 12.1 286.78, 86.8 -60.54, -37.27 in-in in 8.539 Saltbr-in 2.786 HRD-in -65.85, -49.34 77.48, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.08, 164.56 APE9-dihe-na 127.57, -173.24 APE8-dihe-in -123.98, 130.3 APE8-rot-in 296.56 APE67-dihe-in -63.09, -20.07 -49.59, -44.96 APE12-dist-in 7.83 APE11-dist-in 10.746 APE10-dist-in 5.025 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 1.7 0.217 0.198 A 311 282 0 0 0 0 [[82, 342]] 1.0 3rcj AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVLA O15530 74 359 556.0 537:401 Type1 Active DFGin 6.596 14.602 BLAminus DFGAsp-rot-in -130.64, -179.01 78.07, 78.29 191.88, 12.9 -107.64, 5.9 287.24, 98.42 -64.3, -24.0 in-in in 8.293 Saltbr-in 2.558 HRD-in -74.44, -52.48 78.34, -12.89 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.91, 163.01 APE9-dihe-na 134.48, -168.83 APE8-dihe-in -131.23, 133.97 APE8-rot-in 296.05 APE67-dihe-in -61.17, -24.01 -50.83, -47.55 APE12-dist-in 7.321 APE11-dist-in 10.47 APE10-dist-in 4.881 APE9-dist-in 3.565 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.154 0.178 A 311 286 0 0 0 0 [[82, 342]] 1.0 5lvl AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVMA O15530 76 359 556.0 ADE:401 Type1 Active DFGin 6.515 14.858 BLAminus DFGAsp-rot-in -134.29, -178.73 78.5, 76.19 196.79, 18.83 -107.92, 3.05 284.81, 100.85 -68.49, -15.39 in-in in 8.399 Saltbr-in 2.922 HRD-in -74.83, -53.98 76.68, -6.53 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 160.72 APE9-dihe-na 136.54, -165.87 APE8-dihe-in -131.32, 134.23 APE8-rot-in 298.42 APE67-dihe-in -62.0, -21.56 -53.2, -46.03 APE12-dist-in 7.426 APE11-dist-in 10.557 APE10-dist-in 4.949 APE9-dist-in 3.534 Y288G,Q292A SEP241 SEP241 XRAY 1.26 0.135 0.155 A 311 284 0 0 0 0 [[82, 342]] 1.0 5lvm AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.493 14.784 BLAminus DFGAsp-rot-in -138.56, -175.41 73.41, 75.09 199.3, 25.53 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.435 Saltbr-in 2.739 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.439 APE11-dist-in 10.533 APE10-dist-in 4.893 APE9-dist-in 3.566 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311 285 0 0 0 0 [[82, 342]] 1.0 5lvn AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PKN1 PKN1_HUMAN AF-Q16512-K1A Q16512 607 882 942.0 No_ligand No_ligand Active DFGin 6.125 12.803 BLAminus DFGAsp-rot-in -104.04, -164.64 32.68, 89.18 203.0, 3.6 -91.79, 14.64 301.92, 91.88 -63.04, -27.24 in-in in 9.067 Saltbr-in 2.671 HRD-in -84.1, -49.81 66.41, 1.28 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.08, 154.4 APE9-dihe-na 137.89, 173.8 APE8-dihe-in -75.84, 131.35 APE8-rot-in 298.99 APE67-dihe-in -68.2, -19.42 -47.26, -48.97 APE12-dist-in 8.484 APE11-dist-in 11.508 APE10-dist-in 5.848 APE9-dist-in 3.561 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[615, 874]] 1.0 AF-Q16512-K1 AGC_PKN1_HUMAN AGC 9.3e-91 309.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN AF-Q16512-K3A Q16512 607 882 942.0 No_ligand No_ligand Active DFGin 5.87 13.023 BLAminus DFGAsp-rot-in -110.25, -171.62 42.06, 78.21 204.99, 8.68 -81.03, 13.32 306.32, 97.97 -64.16, -27.17 in-in in 8.964 Saltbr-in 2.7 HRD-in -80.36, -49.64 68.98, 3.43 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.89, 155.38 APE9-dihe-na 131.55, -178.6 APE8-dihe-in -90.87, 131.72 APE8-rot-in 298.43 APE67-dihe-in -65.82, -21.14 -44.47, -52.21 APE12-dist-in 8.575 APE11-dist-in 11.483 APE10-dist-in 5.841 APE9-dist-in 3.369 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[615, 874]] 1.0 AF-Q16512-K3 AGC_PKN1_HUMAN AGC 9.3e-91 309.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN2 PKN2_HUMAN AF-Q16513-K1A Q16513 649 924 984.0 No_ligand No_ligand Active DFGin 6.179 12.729 BLAminus DFGAsp-rot-in -104.78, -164.2 32.17, 86.42 204.16, -1.05 -87.58, 14.2 304.86, 114.56 -62.49, -27.35 in-in in 9.006 Saltbr-in 2.648 HRD-in -83.07, -50.09 65.54, -0.41 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.04, 155.51 APE9-dihe-na 136.28, 173.3 APE8-dihe-in -75.79, 131.33 APE8-rot-in 298.91 APE67-dihe-in -68.12, -19.4 -47.06, -49.21 APE12-dist-in 8.485 APE11-dist-in 11.511 APE10-dist-in 5.853 APE9-dist-in 3.567 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[657, 916]] 1.0 AF-Q16513-K1 AGC_PKN2_HUMAN AGC 3.4e-95 324.0 1 260 260 799 800 801 803 805 686 705 709 779 781 780 782 839 827 822 821 820 819 818 817 816 738 Serine/threonine-protein kinase N2
AGC PKN2 PKN2_HUMAN AF-Q16513-K3A Q16513 649 924 984.0 No_ligand No_ligand Active DFGin 6.155 13.031 BLAminus DFGAsp-rot-in -110.59, -176.82 43.27, 87.9 204.69, 1.71 -86.69, 13.51 305.95, 120.87 -62.78, -28.87 in-in in 9.03 Saltbr-in 2.64 HRD-in -78.44, -51.01 68.76, 3.8 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.46, 154.22 APE9-dihe-na 132.16, 175.84 APE8-dihe-in -81.22, 133.36 APE8-rot-in 279.53 APE67-dihe-in -65.51, -20.27 -44.08, -52.92 APE12-dist-in 8.58 APE11-dist-in 11.4 APE10-dist-in 5.77 APE9-dist-in 3.406 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[657, 916]] 1.0 AF-Q16513-K3 AGC_PKN2_HUMAN AGC 3.4e-95 324.0 1 260 260 799 800 801 803 805 686 705 709 779 781 780 782 839 827 822 821 820 819 818 817 816 738 Serine/threonine-protein kinase N2
AGC PKN3 PKN3_HUMAN AF-Q6P5Z2-K1A Q6P5Z2 551 826 889.0 No_ligand No_ligand Active DFGin 6.213 12.713 BLAminus DFGAsp-rot-in -108.29, -162.23 28.36, 90.15 205.62, -1.39 -92.7, 15.89 303.19, 91.08 -64.78, -25.98 in-in in 8.816 Saltbr-in 2.676 HRD-in -86.48, -52.08 64.95, 2.74 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.84, 156.99 APE9-dihe-na 136.91, 173.5 APE8-dihe-in -75.44, 130.67 APE8-rot-in 299.0 APE67-dihe-in -68.06, -21.81 -47.48, -46.99 APE12-dist-in 8.511 APE11-dist-in 11.521 APE10-dist-in 5.87 APE9-dist-in 3.542 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[559, 818]] 1.0 AF-Q6P5Z2-K1 AGC_PKN3_HUMAN AGC 5.5e-88 300.4 1 260 260 701 702 703 705 707 588 607 611 681 683 682 684 741 729 724 723 722 721 720 719 718 640 Serine/threonine-protein kinase N3
AGC PKN3 PKN3_HUMAN AF-Q6P5Z2-K3A Q6P5Z2 551 826 889.0 No_ligand No_ligand Active DFGin 5.991 12.817 BLAminus DFGAsp-rot-in -113.6, -173.17 41.21, 88.04 206.31, -4.26 -90.03, 15.6 305.64, 101.61 -64.6, -27.59 in-in in 8.734 Saltbr-in 2.649 HRD-in -85.04, -52.23 68.56, 8.23 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.23, 154.67 APE9-dihe-na 136.51, -175.68 APE8-dihe-in -92.57, 130.9 APE8-rot-in 297.39 APE67-dihe-in -65.24, -22.49 -44.55, -51.17 APE12-dist-in 8.514 APE11-dist-in 11.482 APE10-dist-in 5.852 APE9-dist-in 3.352 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[559, 818]] 1.0 AF-Q6P5Z2-K3 AGC_PKN3_HUMAN AGC 5.5e-88 300.4 1 260 260 701 702 703 705 707 588 607 611 681 683 682 684 741 729 724 723 722 721 720 719 718 640 Serine/threonine-protein kinase N3
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.684 14.414 BLAminus DFGAsp-rot-in -121.45, -177.2 62.67, 77.75 196.78, -6.91 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.913 Saltbr-in 2.759 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.098 APE11-dist-in 11.392 APE10-dist-in 5.827 APE9-dist-in 3.498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337 336 0 0 0 0 [[44, 298]] 1.0 4wb8 AGC_PRKACA_HUMAN AGC 4.1e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.6 14.452 BLAminus DFGAsp-rot-in -123.05, 176.84 68.94, 80.02 197.37, -7.71 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.03 Saltbr-in 2.715 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.012 APE11-dist-in 11.4 APE10-dist-in 5.799 APE9-dist-in 3.567 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb5 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.445 14.649 BLAminus DFGAsp-rot-in -119.06, -174.39 59.4, 77.28 195.74, -3.82 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.87 Saltbr-in 2.769 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.18 APE11-dist-in 11.54 APE10-dist-in 5.955 APE9-dist-in 3.723 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.38 14.712 BLAminus DFGAsp-rot-in -115.93, -176.79 62.38, 75.33 194.29, -4.22 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.962 Saltbr-in 2.773 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.198 APE11-dist-in 11.563 APE10-dist-in 5.97 APE9-dist-in 3.642 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.626 14.616 BLAminus DFGAsp-rot-in -128.29, 177.03 62.06, 86.64 183.58, 14.0 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.808 Saltbr-in 3.196 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.734 APE11-dist-in 11.076 APE10-dist-in 5.63 APE9-dist-in 3.491 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.679 14.34 BLAminus DFGAsp-rot-in -129.89, 172.29 61.76, 74.25 173.55, 39.57 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.733 Saltbr-in 2.498 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.316 APE11-dist-in 11.106 APE10-dist-in 5.767 APE9-dist-in 3.618 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.626 13.772 BLAminus DFGAsp-rot-in -125.61, -173.52 60.53, 69.6 195.3, -1.08 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.129 Saltbr-in 3.0 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.14 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.999 APE11-dist-in 11.111 APE10-dist-in 5.797 APE9-dist-in 3.748 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edc AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.068 14.398 BLAminus DFGAsp-rot-in -118.38, -169.49 51.77, 82.47 196.99, -10.62 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.83 Saltbr-in 2.561 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.046 APE11-dist-in 11.764 APE10-dist-in 6.243 APE9-dist-in 3.767 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.8e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.872 14.073 BLAminus DFGAsp-rot-in -117.82, -168.32 53.27, 78.35 192.68, -12.16 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.687 Saltbr-in 2.75 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.617 APE10-dist-in 6.204 APE9-dist-in 3.822 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350 343 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.8e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5J5XA P17612 10 351 351.0 6J9:60404 Allosteric Active DFGin 6.131 14.267 BLAminus DFGAsp-rot-in -130.51, 173.14 68.75, 93.05 211.2, -45.33 -105.74, 27.05 279.27, 61.24 -64.37, -20.92 in-in in 8.495 Saltbr-in 2.736 HRD-in -82.45, -52.91 66.97, 1.69 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.53, 148.7 APE9-dihe-na 119.01, 165.11 APE8-dihe-in -70.44, 134.99 APE8-rot-in 296.24 APE67-dihe-in -60.26, -38.48 -54.53, -34.6 APE12-dist-in 7.811 APE11-dist-in 11.133 APE10-dist-in 5.601 APE9-dist-in 3.989 None TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.24 0.309 A 351 342 0 0 0 0 [[44, 298]] 1.0 5j5x AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN AF-P17612-K1A P17612 36 306 351.0 No_ligand No_ligand Active DFGin 5.955 14.101 BLAminus DFGAsp-rot-in -112.06, -162.49 41.01, 73.74 200.88, 17.4 -80.57, 22.27 279.02, 69.01 -57.23, -32.63 in-in in 8.73 Saltbr-in 2.607 HRD-in -81.22, -48.08 66.27, 5.12 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.31, 161.49 APE9-dihe-na 113.97, -179.99 APE8-dihe-in -91.88, 135.09 APE8-rot-in 302.21 APE67-dihe-in -65.91, -23.79 -48.59, -45.69 APE12-dist-in 8.056 APE11-dist-in 11.478 APE10-dist-in 5.716 APE9-dist-in 3.496 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P17612-K1 AGC_PRKACA_HUMAN AGC 1.9e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN AF-P17612-K3A P17612 36 306 351.0 No_ligand No_ligand Active DFGin 5.989 14.182 BLAminus DFGAsp-rot-in -127.06, -175.23 47.34, 85.15 204.74, -16.87 -88.29, 17.62 289.75, 82.76 -56.25, -31.52 in-in in 8.798 Saltbr-in 2.649 HRD-in -85.43, -51.15 69.13, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.07, 161.67 APE9-dihe-na 110.83, -179.43 APE8-dihe-in -90.4, 132.09 APE8-rot-in 300.17 APE67-dihe-in -66.95, -21.36 -48.38, -45.21 APE12-dist-in 8.072 APE11-dist-in 11.156 APE10-dist-in 5.49 APE9-dist-in 3.416 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P17612-K3 AGC_PRKACA_HUMAN AGC 1.9e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7C P17612 12 351 351.0 No_ligand No_ligand Active DFGin 5.309 14.041 BLAminus DFGAsp-rot-in -119.31, 176.37 65.24, 77.94 194.93, -1.32 -84.43, 19.43 273.37, 51.07 -43.97, -41.52 in-in in 8.987 Saltbr-in 2.36 HRD-in -94.38, -54.81 73.77, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.7, 149.95 APE9-dihe-na 149.29, -142.75 APE8-dihe-in -132.31, 130.88 APE8-rot-in 297.15 APE67-dihe-in -65.36, -25.54 -38.33, -55.04 APE12-dist-in 8.372 APE11-dist-in 10.863 APE10-dist-in 5.572 APE9-dist-in 3.16 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 C 350 340 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGMA P17612 13 351 351.0 No_ligand No_ligand Active DFGin 6.446 13.402 BLAminus DFGAsp-rot-in -121.71, 165.51 70.43, 93.14 197.46, -19.7 -102.22, 24.88 291.91, 69.39 -56.91, -34.43 in-in in 8.76 Saltbr-in 2.802 HRD-in -90.0, -49.9 65.54, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 155.53 APE9-dihe-na 129.13, -155.89 APE8-dihe-in -119.08, 128.77 APE8-rot-in 315.26 APE67-dihe-in -58.72, -28.41 -42.89, -48.17 APE12-dist-in 7.962 APE11-dist-in 11.34 APE10-dist-in 5.789 APE9-dist-in 3.839 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.277 0.265 A 351 339 0 0 0 0 [[44, 298]] 1.0 3agm AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5IZFA P17612 14 351 351.0 No_ligand No_ligand Active DFGin 6.469 14.681 BLAminus DFGAsp-rot-in -115.33, 168.85 66.79, 92.72 197.91, -8.29 -104.07, 26.57 271.02, 67.91 -60.32, -26.19 in-in in 8.92 Saltbr-in 2.86 HRD-in -91.12, -53.12 70.24, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 154.6 APE9-dihe-na 132.55, -178.51 APE8-dihe-in -93.41, 131.47 APE8-rot-in 300.25 APE67-dihe-in -61.6, -25.88 -48.77, -44.1 APE12-dist-in 7.999 APE11-dist-in 11.651 APE10-dist-in 5.984 APE9-dist-in 4.143 None TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.232 0.27 A 351 338 0 0 0 0 [[44, 298]] 1.0 5izf AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3NX8A P17612 16 351 351.0 No_ligand No_ligand Active DFGin 6.217 14.321 BLAminus DFGAsp-rot-in -121.41, 174.36 68.59, 92.57 202.99, -30.78 -100.19, 21.71 266.05, 56.03 -54.66, -29.9 in-in in 8.867 Saltbr-in 3.095 HRD-in -83.14, -56.31 66.43, 12.16 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.5, 160.02 APE9-dihe-na 128.98, -158.22 APE8-dihe-in -117.99, 132.74 APE8-rot-in 294.49 APE67-dihe-in -53.23, -32.68 -47.46, -50.82 APE12-dist-in 8.049 APE11-dist-in 11.428 APE10-dist-in 5.853 APE9-dist-in 3.626 None TPO198,SEP339 TPO198,LGY293,SEP339 XRAY 2.0 0.22 0.288 A 351 336 0 0 0 0 [[44, 298]] 1.0 3nx8 AGC_PRKACA_HUMAN AGC 3e-94 321.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9DCDA P17612 14 351 351.0 A1A3J:60401 Type1 Active DFGin 5.929 14.45 BLAminus DFGAsp-rot-in -126.13, 173.68 64.63, 91.94 197.49, -17.64 -99.88, 28.46 273.99, 56.84 -61.81, -26.4 in-in in 9.125 Saltbr-in 2.729 HRD-in -91.13, -53.48 71.25, 11.66 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.7, 158.74 APE9-dihe-na 136.61, -155.83 APE8-dihe-in -120.28, 133.14 APE8-rot-in 302.66 APE67-dihe-in -56.79, -23.93 -44.41, -54.9 APE12-dist-in 8.029 APE11-dist-in 11.442 APE10-dist-in 5.913 APE9-dist-in 3.617 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.7 0.174 0.191 A 350 338 0 0 0 0 [[44, 298]] 1.0 9dcd AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGLA P17612 11 351 351.0 A03:60351 Type1 Active DFGin 6.145 14.187 BLAminus DFGAsp-rot-in -123.32, 177.62 64.25, 83.52 198.9, -10.58 -96.46, 22.51 272.11, 61.62 -58.64, -28.46 in-in in 8.491 Saltbr-in 2.886 HRD-in -82.44, -53.5 74.32, 9.67 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.19, 166.18 APE9-dihe-na 128.76, -154.1 APE8-dihe-in -126.1, 126.27 APE8-rot-in 292.64 APE67-dihe-in -59.45, -23.51 -43.73, -52.47 APE12-dist-in 8.09 APE11-dist-in 11.285 APE10-dist-in 5.642 APE9-dist-in 3.692 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.2 0.237 A 351 341 0 0 0 0 [[44, 298]] 1.0 3agl AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGLB P17612 15 351 351.0 A03:60351 Type1 Active DFGin 6.244 14.259 BLAminus DFGAsp-rot-in -119.17, 172.99 64.04, 88.92 196.61, -12.73 -97.96, 24.36 271.27, 65.91 -60.24, -24.04 in-in in 8.483 Saltbr-in 2.838 HRD-in -81.23, -56.2 72.88, 10.89 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.17, 153.35 APE9-dihe-na 137.51, -153.25 APE8-dihe-in -122.43, 130.68 APE8-rot-in 303.24 APE67-dihe-in -59.0, -24.94 -49.14, -44.94 APE12-dist-in 8.082 APE11-dist-in 11.322 APE10-dist-in 5.744 APE9-dist-in 3.881 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.2 0.237 B 351 337 0 0 0 0 [[44, 298]] 1.0 3agl AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9LA P17612 12 351 351.0 L9L:60351 Type1 Active DFGin 6.686 14.585 BLAminus DFGAsp-rot-in -131.42, 170.84 67.14, 98.79 201.59, -25.27 -112.52, 31.48 281.78, 68.95 -76.6, -5.02 in-in in 9.118 Saltbr-in 3.022 HRD-in -66.86, -56.55 70.6, 11.25 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.79, 159.06 APE9-dihe-na 115.3, -161.08 APE8-dihe-in -112.72, 124.05 APE8-rot-in 306.01 APE67-dihe-in -58.13, -24.33 -29.04, -60.55 APE12-dist-in 8.35 APE11-dist-in 11.188 APE10-dist-in 5.587 APE9-dist-in 3.515 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.262 A 351 340 0 0 0 0 [[44, 298]] 1.0 3l9l AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9LB P17612 13 351 351.0 L9L:60351 Type1 Active DFGin 6.504 14.748 BLAminus DFGAsp-rot-in -126.06, 169.3 70.23, 93.91 198.58, -19.42 -105.72, 28.14 277.25, 72.68 -68.61, -5.61 in-in in 9.122 Saltbr-in 3.092 HRD-in -71.18, -54.73 64.89, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 167.34 APE9-dihe-na 115.39, -170.56 APE8-dihe-in -110.93, 132.83 APE8-rot-in 304.32 APE67-dihe-in -49.56, -29.7 -32.05, -69.65 APE12-dist-in 8.223 APE11-dist-in 11.294 APE10-dist-in 5.685 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.262 B 351 339 0 0 0 0 [[44, 298]] 1.0 3l9l AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OOGA P17612 17 351 351.0 YTP:62001 Type1 Active DFGin 5.897 14.324 BLAminus DFGAsp-rot-in -121.7, 177.27 65.88, 89.72 198.64, -14.4 -99.72, 18.72 271.46, 61.56 -55.08, -24.51 in-in in 9.092 Saltbr-in 2.564 HRD-in -88.93, -49.19 62.2, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.22, 156.24 APE9-dihe-na 130.48, -158.98 APE8-dihe-in -121.53, 132.57 APE8-rot-in 295.61 APE67-dihe-in -56.76, -31.12 -46.34, -49.72 APE12-dist-in 8.184 APE11-dist-in 11.561 APE10-dist-in 5.99 APE9-dist-in 3.782 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.276 A 351 335 0 0 0 0 [[44, 298]] 1.0 3oog AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OVVA P17612 15 351 351.0 1SB:62001 Type1 Active DFGin 5.695 14.513 BLAminus DFGAsp-rot-in -122.03, 173.75 63.75, 85.64 192.68, -15.9 -91.93, 24.88 270.34, 49.38 -58.53, -29.2 in-in in 9.157 Saltbr-in 2.643 HRD-in -85.42, -51.64 68.38, 18.21 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.97, 161.66 APE9-dihe-na 131.92, -151.97 APE8-dihe-in -126.88, 132.92 APE8-rot-in 299.89 APE67-dihe-in -61.32, -22.22 -45.4, -52.6 APE12-dist-in 8.128 APE11-dist-in 11.55 APE10-dist-in 5.907 APE9-dist-in 3.531 None TPO198,SEP339 TPO198,SEP339 XRAY 1.58 0.186 0.232 A 351 337 0 0 0 0 [[44, 298]] 1.0 3ovv AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OWPA P17612 16 351 351.0 2SB:62001 Type1 Active DFGin 5.797 14.577 BLAminus DFGAsp-rot-in -129.79, 179.44 68.22, 88.81 199.91, -15.39 -97.88, 23.63 269.47, 50.63 -59.8, -24.73 in-in in 9.021 Saltbr-in 2.648 HRD-in -91.6, -55.1 70.56, 10.08 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 156.32 APE9-dihe-na 133.26, -159.94 APE8-dihe-in -117.71, 131.95 APE8-rot-in 303.89 APE67-dihe-in -56.68, -26.5 -44.05, -53.81 APE12-dist-in 8.079 APE11-dist-in 11.53 APE10-dist-in 5.947 APE9-dist-in 3.825 None TPO198,SEP339 TPO198,SEP339 XRAY 1.88 0.172 0.211 A 351 336 0 0 0 0 [[44, 298]] 1.0 3owp AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OXTA P17612 15 351 351.0 3SB:62001 Type1 Active DFGin 5.724 14.322 BLAminus DFGAsp-rot-in -130.49, 176.59 67.71, 88.75 205.31, -21.95 -96.86, 20.88 271.58, 55.14 -54.8, -35.77 in-in in 9.108 Saltbr-in 2.754 HRD-in -88.64, -56.71 72.64, 4.73 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.01, 154.62 APE9-dihe-na 133.52, -155.05 APE8-dihe-in -117.36, 129.13 APE8-rot-in 302.02 APE67-dihe-in -56.32, -26.92 -42.89, -52.47 APE12-dist-in 8.269 APE11-dist-in 11.861 APE10-dist-in 6.261 APE9-dist-in 4.109 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.176 0.239 A 351 337 0 0 0 0 [[44, 298]] 1.0 3oxt AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3P0MA P17612 15 351 351.0 4SB:60351 Type1 Active DFGin 5.923 14.578 BLAminus DFGAsp-rot-in -120.95, -179.03 59.8, 84.94 195.98, -7.43 -96.45, 19.28 269.08, 54.31 -49.85, -35.86 in-in in 9.001 Saltbr-in 2.66 HRD-in -87.41, -52.38 71.61, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.78, 160.64 APE9-dihe-na 131.62, -157.52 APE8-dihe-in -119.88, 133.57 APE8-rot-in 304.97 APE67-dihe-in -52.04, -26.97 -43.23, -57.05 APE12-dist-in 8.019 APE11-dist-in 11.477 APE10-dist-in 5.887 APE9-dist-in 3.658 None TPO198,SEP339 TPO198,SEP339 XRAY 2.03 0.171 0.205 A 351 337 0 0 0 0 [[44, 298]] 1.0 3p0m AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3POOA P17612 15 351 351.0 S69:62001 Type1 Active DFGin 5.688 14.66 BLAminus DFGAsp-rot-in -122.77, 177.28 59.44, 86.58 197.54, -7.06 -95.62, 24.37 267.18, 52.33 -56.67, -28.22 in-in in 9.226 Saltbr-in 2.614 HRD-in -88.33, -52.91 73.26, 10.11 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 158.93 APE9-dihe-na 133.77, -158.97 APE8-dihe-in -121.67, 134.24 APE8-rot-in 298.67 APE67-dihe-in -57.61, -22.88 -45.78, -52.79 APE12-dist-in 8.096 APE11-dist-in 11.527 APE10-dist-in 5.938 APE9-dist-in 3.556 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.187 0.212 A 351 333 0 0 0 0 [[44, 298]] 1.0 3poo AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5BX6A P17612 6 351 351.0 495:60401 Type1 Active DFGin 6.183 14.303 BLAminus DFGAsp-rot-in -119.55, 164.86 70.92, 91.57 197.89, -12.96 -100.18, 26.65 271.79, 52.76 -61.33, -23.25 in-in in 8.906 Saltbr-in 2.708 HRD-in -93.87, -50.75 70.32, 10.63 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.15, 164.21 APE9-dihe-na 125.51, -162.2 APE8-dihe-in -117.48, 134.41 APE8-rot-in 303.65 APE67-dihe-in -56.37, -27.52 -46.12, -51.63 APE12-dist-in 8.075 APE11-dist-in 11.455 APE10-dist-in 5.918 APE9-dist-in 3.601 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.89 0.172 0.218 A 351 346 0 0 0 0 [[44, 298]] 1.0 5bx6 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5BX7A P17612 6 350 351.0 4W1:60401 Type1 Active DFGin 5.893 14.257 BLAminus DFGAsp-rot-in -120.21, 170.97 66.4, 95.24 202.52, -17.27 -104.96, 26.38 271.55, 55.44 -58.59, -27.02 in-in in 8.887 Saltbr-in 2.646 HRD-in -91.82, -48.84 66.55, 10.61 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.67, 162.65 APE9-dihe-na 129.46, -159.53 APE8-dihe-in -119.63, 133.68 APE8-rot-in 305.25 APE67-dihe-in -56.25, -25.43 -45.01, -52.75 APE12-dist-in 8.11 APE11-dist-in 11.518 APE10-dist-in 5.961 APE9-dist-in 3.581 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.89 0.178 0.226 A 351 345 0 0 0 0 [[44, 298]] 1.0 5bx7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5UZKA P17612 15 351 351.0 504:60401 Type1 Active DFGin 6.381 13.948 BLAminus DFGAsp-rot-in -125.23, 159.32 70.49, 97.31 201.36, -17.78 -104.94, 23.81 281.36, 67.83 -60.03, -27.16 in-in in 8.88 Saltbr-in 2.765 HRD-in -81.16, -49.29 61.5, 17.59 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.44, 160.74 APE9-dihe-na 127.01, -154.99 APE8-dihe-in -117.26, 132.5 APE8-rot-in 297.37 APE67-dihe-in -55.36, -26.76 -39.46, -56.34 APE12-dist-in 8.011 APE11-dist-in 11.394 APE10-dist-in 5.83 APE9-dist-in 3.588 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.191 0.253 A 351 337 0 0 0 0 [[44, 298]] 1.0 5uzk AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6QJ7A P17612 14 351 351.0 J4B:60401 Type1 Active DFGin 6.371 14.879 BLAminus DFGAsp-rot-in -117.39, 169.65 69.58, 85.56 196.66, -4.98 -98.1, 21.35 272.03, 58.03 -54.77, -30.7 in-in in 9.214 Saltbr-in 2.75 HRD-in -87.29, -50.94 66.9, 9.43 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.01, 157.32 APE9-dihe-na 126.55, -163.63 APE8-dihe-in -112.81, 131.54 APE8-rot-in 300.45 APE67-dihe-in -57.75, -27.43 -43.16, -51.25 APE12-dist-in 8.004 APE11-dist-in 11.506 APE10-dist-in 5.846 APE9-dist-in 3.703 None TPO198,SEP339 TPO198,SEP339 XRAY 1.69 0.179 0.214 A 351 338 0 0 0 0 [[44, 298]] 1.0 6qj7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3MVJA P17612 16 351 351.0 XFE:60351 Type1 Active DFGin 6.188 13.582 BLAminus DFGAsp-rot-in -115.88, 169.36 72.34, 84.05 212.56, -48.08 -100.4, 21.07 284.54, 72.78 -48.33, -32.34 in-in in 8.693 Saltbr-in 2.943 HRD-in -94.45, -57.98 81.77, 7.12 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.5, 165.11 APE9-dihe-na 130.23, -153.23 APE8-dihe-in -130.91, 127.14 APE8-rot-in 305.92 APE67-dihe-in -54.4, -32.7 -46.27, -53.24 APE12-dist-in 8.165 APE11-dist-in 11.441 APE10-dist-in 5.835 APE9-dist-in 3.678 None TPO198,SEP339 TPO198,SEP339 XRAY 2.49 0.217 0.304 A 371 336 0 0 0 0 [[44, 298]] 1.0 3mvj AGC_PRKACA_HUMAN AGC 5.6e-95 323.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3MVJE P17612 16 351 351.0 XFE:60351 Type1 Active DFGin 6.01 13.904 BLAminus DFGAsp-rot-in -120.77, 173.49 75.79, 91.53 221.62, -16.98 -105.05, 22.03 286.9, 73.04 -48.68, -45.44 in-in in 8.786 Saltbr-in 2.504 HRD-in -85.62, -59.75 66.22, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.99, 156.89 APE9-dihe-na 143.78, -161.15 APE8-dihe-in -124.44, 132.79 APE8-rot-in 305.29 APE67-dihe-in -69.91, -25.33 -54.9, -34.25 APE12-dist-in 8.148 APE11-dist-in 11.447 APE10-dist-in 5.803 APE9-dist-in 3.801 None TPO198,SEP339 TPO198,SEP339 XRAY 2.49 0.217 0.304 E 371 336 0 0 0 0 [[44, 298]] 1.0 3mvj AGC_PRKACA_HUMAN AGC 5.6e-95 323.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9MA P17612 12 351 351.0 L9M:60351 Type1 Active DFGin 6.702 13.68 BLAminus DFGAsp-rot-in -123.42, 168.26 64.27, 97.86 199.47, -23.49 -112.03, 32.77 297.13, 76.75 -74.15, -5.52 in-in in 9.035 Saltbr-in 2.793 HRD-in -71.88, -60.17 71.32, 14.02 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.62, 165.36 APE9-dihe-na 118.63, -161.51 APE8-dihe-in -116.7, 125.6 APE8-rot-in 304.73 APE67-dihe-in -59.86, -22.26 -32.71, -59.17 APE12-dist-in 8.187 APE11-dist-in 11.209 APE10-dist-in 5.617 APE9-dist-in 3.571 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.223 0.27 A 351 340 0 0 0 0 [[44, 298]] 1.0 3l9m AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9MB P17612 14 351 351.0 L9M:60351 Type1 Active DFGin 6.767 13.738 BLAminus DFGAsp-rot-in -124.39, 166.06 67.02, 98.19 199.53, -25.11 -111.82, 31.79 294.5, 74.52 -67.48, -11.73 in-in in 8.878 Saltbr-in 2.913 HRD-in -76.18, -53.82 65.92, 13.75 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.4, 166.8 APE9-dihe-na 115.45, -164.35 APE8-dihe-in -115.85, 130.97 APE8-rot-in 297.34 APE67-dihe-in -54.51, -26.46 -29.85, -67.98 APE12-dist-in 8.224 APE11-dist-in 11.263 APE10-dist-in 5.658 APE9-dist-in 3.558 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.223 0.27 B 351 338 0 0 0 0 [[44, 298]] 1.0 3l9m AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9NA P17612 15 351 351.0 L9N:60351 Type1 Active DFGin 6.423 13.46 BLAminus DFGAsp-rot-in -123.73, 167.95 65.98, 97.53 204.12, -34.05 -115.01, 25.76 300.78, 81.96 -66.98, -19.82 in-in in 9.05 Saltbr-in 2.744 HRD-in -67.38, -52.97 66.43, 17.24 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.06, 165.76 APE9-dihe-na 122.47, -160.51 APE8-dihe-in -116.6, 130.05 APE8-rot-in 304.11 APE67-dihe-in -53.81, -24.08 -30.84, -70.07 APE12-dist-in 8.197 APE11-dist-in 11.394 APE10-dist-in 5.934 APE9-dist-in 3.553 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.217 0.257 A 351 334 0 0 0 0 [[44, 298]] 1.0 3l9n AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE2A P17612 4 351 351.0 XTI:60501 Type1 Active DFGin 6.142 13.913 BLAminus DFGAsp-rot-in -123.85, 174.03 69.38, 86.41 196.47, -7.09 -105.22, 28.0 281.98, 71.1 -68.62, -14.04 in-in in 8.854 Saltbr-in 2.514 HRD-in -84.66, -51.16 67.93, 20.04 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.46, 164.95 APE9-dihe-na 122.51, -154.32 APE8-dihe-in -114.26, 125.71 APE8-rot-in 301.9 APE67-dihe-in -53.15, -32.01 -48.08, -46.83 APE12-dist-in 8.315 APE11-dist-in 11.573 APE10-dist-in 6.003 APE9-dist-in 3.939 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.34 0.199 0.251 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fe2 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE2B P17612 4 351 351.0 XTI:60501 Type1 Active DFGin 6.227 13.875 BLAminus DFGAsp-rot-in -121.06, -174.83 58.15, 84.69 198.37, -17.08 -101.22, 28.39 282.36, 54.58 -64.33, -23.67 in-in in 8.861 Saltbr-in 2.936 HRD-in -86.41, -49.46 70.11, 7.42 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.54, 160.4 APE9-dihe-na 134.47, -156.72 APE8-dihe-in -118.93, 133.24 APE8-rot-in 292.47 APE67-dihe-in -59.44, -24.84 -53.68, -43.95 APE12-dist-in 8.112 APE11-dist-in 11.51 APE10-dist-in 5.875 APE9-dist-in 3.792 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.34 0.199 0.251 B 405 333 0 0 0 0 [[44, 298]] 1.0 8fe2 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE5A P17612 3 351 351.0 XTT:60501 Type1 Active DFGin 6.6 14.271 BLAminus DFGAsp-rot-in -118.08, 163.41 75.28, 94.71 203.28, -12.14 -111.66, 23.11 283.47, 69.64 -61.06, -23.26 in-in in 8.668 Saltbr-in 2.794 HRD-in -90.95, -53.69 70.13, 22.37 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.31, 157.71 APE9-dihe-na 120.85, -158.74 APE8-dihe-in -109.76, 129.18 APE8-rot-in 307.33 APE67-dihe-in -52.63, -34.99 -47.86, -48.55 APE12-dist-in 8.409 APE11-dist-in 11.54 APE10-dist-in 5.918 APE9-dist-in 3.881 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.51 0.193 0.243 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fe5 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE5B P17612 4 351 351.0 XTT:60501 Type1 Active DFGin 6.585 14.16 BLAminus DFGAsp-rot-in -125.03, 171.21 68.33, 95.08 204.51, -14.37 -111.16, 25.84 279.92, 72.93 -61.92, -29.97 in-in in 8.694 Saltbr-in 2.655 HRD-in -80.97, -54.69 77.96, 3.27 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.98, 153.65 APE9-dihe-na 132.84, -165.24 APE8-dihe-in -101.75, 136.64 APE8-rot-in 293.15 APE67-dihe-in -60.99, -28.63 -57.01, -42.49 APE12-dist-in 8.343 APE11-dist-in 11.666 APE10-dist-in 6.076 APE9-dist-in 3.865 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.51 0.193 0.243 B 405 336 0 0 0 0 [[44, 298]] 1.0 8fe5 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FECA P17612 3 351 351.0 XU0:60501 Type1 Active DFGin 5.927 14.461 BLAminus DFGAsp-rot-in -126.38, -179.91 61.84, 90.42 206.73, -8.83 -102.64, 31.23 279.77, 62.7 -61.22, -32.63 in-in in 9.155 Saltbr-in 3.107 HRD-in -85.43, -52.43 73.91, 14.55 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.02, 165.29 APE9-dihe-na 137.47, -140.99 APE8-dihe-in -132.86, 123.05 APE8-rot-in 312.11 APE67-dihe-in -60.14, -32.0 -40.12, -49.13 APE12-dist-in 8.232 APE11-dist-in 11.562 APE10-dist-in 5.955 APE9-dist-in 3.606 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.7 0.214 0.287 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fec AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FECB P17612 3 351 351.0 XU0:60501 Type1 Active DFGin 5.975 14.684 BLAminus DFGAsp-rot-in -127.65, 171.34 68.29, 92.72 207.63, -0.98 -102.21, 27.6 281.7, 67.04 -60.34, -31.82 in-in in 8.84 Saltbr-in 2.809 HRD-in -91.52, -53.88 75.61, 9.83 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.24, 178.4 APE9-dihe-na 115.87, -151.85 APE8-dihe-in -128.69, 124.59 APE8-rot-in 281.12 APE67-dihe-in -60.64, -38.43 -38.43, -52.12 APE12-dist-in 8.18 APE11-dist-in 11.378 APE10-dist-in 5.793 APE9-dist-in 3.46 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.214 0.287 B 405 336 0 0 0 0 [[44, 298]] 1.0 8fec AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9NFSA P17612 4 351 351.0 A1BX1:60501 Type1 Active DFGin 6.289 13.616 BLAminus DFGAsp-rot-in -130.7785, 168.6135 68.445, 100.1007 196.8975, -50.7087 -112.4058, 21.0811 282.979, 73.4956 -56.8821, -13.5221 in-in in 8.891 Saltbr-in 3.337 HRD-in -93.0982, -57.1021 79.0878, 19.7924 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.4241, 172.8177 APE9-dihe-na 140.5312, -147.403 APE8-dihe-in -129.0541, 120.1432 APE8-rot-in 289.8434 APE67-dihe-in -57.6402, -31.505 -31.3289, -51.1398 APE12-dist-in 7.963 APE11-dist-in 11.385 APE10-dist-in 5.783 APE9-dist-in 3.659 None TPO198 TPO198 XRAY 2.45 0.282 0.334 A 405 336 0 0 0 0 [[44, 298]] 1.0 9nfs AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9NFSB P17612 4 351 351.0 A1BX1:60501 Type1 Active DFGin 6.023 13.704 BLAminus DFGAsp-rot-in -121.9669, 172.2508 74.2554, 88.121 200.0384, -6.3976 -106.7477, 23.5957 283.7269, 74.2926 -55.4029, -13.3176 in-in in 8.684 Saltbr-in 2.762 HRD-in -107.072, -47.5862 65.993, 15.1387 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.2547, 176.76 APE9-dihe-na 135.9619, -132.0663 APE8-dihe-in -149.8201, 125.8002 APE8-rot-in 307.1569 APE67-dihe-in -54.1174, -49.0959 -37.929, -47.3475 APE12-dist-in 7.889 APE11-dist-in 11.281 APE10-dist-in 5.755 APE9-dist-in 3.467 None TPO198 TPO198 XRAY 2.45 0.282 0.334 B 405 336 0 0 0 0 [[44, 298]] 1.0 9nfs AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 2GU8A P17612 15 351 351.0 796:61001 Type1 Active DFGin 6.63 14.367 BLAminus DFGAsp-rot-in -112.13, 169.56 64.55, 88.46 197.82, -13.56 -98.67, 24.98 279.28, 59.9 -52.79, -25.6 in-in in 8.969 Saltbr-in 3.03 HRD-in -83.27, -51.67 71.2, 9.61 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.43, 156.76 APE9-dihe-na 146.07, -145.55 APE8-dihe-in -129.46, 134.31 APE8-rot-in 294.43 APE67-dihe-in -57.08, -22.75 -50.07, -49.98 APE12-dist-in 8.04 APE11-dist-in 11.469 APE10-dist-in 5.977 APE9-dist-in 3.507 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.203 0.261 A 337 337 0 0 0 0 [[44, 298]] 1.0 2gu8 AGC_PRKACA_HUMAN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5N23A P17612 9 351 351.0 35R:60401 Type1 Active DFGin 5.421 13.864 BLAminus DFGAsp-rot-in -109.83, 165.02 72.7, 94.27 204.39, -32.89 -97.78, 24.01 286.85, 71.32 -58.73, -25.18 in-in in 9.5 Saltbr-in 2.927 HRD-in -90.99, -49.74 71.93, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.89, 153.96 APE9-dihe-na 137.51, -163.29 APE8-dihe-in -116.51, 133.79 APE8-rot-in 303.7 APE67-dihe-in -56.98, -24.74 -46.64, -52.33 APE12-dist-in 8.056 APE11-dist-in 11.585 APE10-dist-in 5.945 APE9-dist-in 3.654 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.088 0.192 0.239 A 352 337 0 0 0 0 [[44, 298]] 1.0 5n23 AGC_PRKACA_HUMAN AGC 5.5e-93 316.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AMAA P17612 2 351 351.0 SKE:60351 Type1 Active DFGin 5.097 14.026 BLAminus DFGAsp-rot-in -113.5, 162.11 72.12, 95.43 207.93, -32.54 -101.12, 20.61 280.01, 66.12 -51.23, -34.47 in-in in 9.396 Saltbr-in 2.734 HRD-in -88.12, -51.56 68.22, 12.75 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.04, 164.64 APE9-dihe-na 124.94, -160.1 APE8-dihe-in -123.9, 133.09 APE8-rot-in 298.24 APE67-dihe-in -57.85, -22.29 -46.67, -50.91 APE12-dist-in 8.102 APE11-dist-in 11.571 APE10-dist-in 5.902 APE9-dist-in 3.582 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.75 0.198 0.223 A 351 345 0 0 0 0 [[44, 298]] 1.0 3ama AGC_PRKACA_HUMAN AGC 8.1e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6FRXA P17612 13 351 351.0 E3Z:60401 Type1 Active DFGin 5.276 14.242 BLAminus DFGAsp-rot-in -103.8, 165.76 62.73, 100.4 214.25, -78.25 -98.82, 30.34 278.36, 58.69 -63.79, -25.19 in-in in 9.307 Saltbr-in 2.635 HRD-in -83.02, -52.27 73.43, 9.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.05, 168.13 APE9-dihe-na 109.0, -164.56 APE8-dihe-in -112.4, 132.82 APE8-rot-in 302.54 APE67-dihe-in -55.48, -26.17 -48.65, -50.5 APE12-dist-in 8.324 APE11-dist-in 11.711 APE10-dist-in 6.118 APE9-dist-in 3.716 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.88 0.191 0.226 A 351 334 0 0 0 0 [[44, 298]] 1.0 6frx AGC_PRKACA_HUMAN AGC 8.1e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACB KAPCB_HUMAN AF-P22694-K1A P22694 36 306 351.0 No_ligand No_ligand Active DFGin 5.735 14.08 BLAminus DFGAsp-rot-in -113.18, -170.6 48.14, 81.8 200.0, 9.2 -87.93, 20.24 276.82, 61.61 -55.85, -32.41 in-in in 8.819 Saltbr-in 2.656 HRD-in -86.21, -47.66 67.2, 5.71 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.21, 165.03 APE9-dihe-na 114.21, -173.02 APE8-dihe-in -104.24, 136.01 APE8-rot-in 300.44 APE67-dihe-in -64.96, -24.87 -48.41, -47.34 APE12-dist-in 8.107 APE11-dist-in 11.463 APE10-dist-in 5.752 APE9-dist-in 3.372 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22694-K1 AGC_PRKACB_HUMAN AGC 6.8e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit beta
AGC PRKACB KAPCB_HUMAN AF-P22694-K3A P22694 36 306 351.0 No_ligand No_ligand Active DFGin 5.906 14.07 BLAminus DFGAsp-rot-in -127.45, -176.84 50.2, 78.93 205.02, -10.14 -82.9, 18.23 290.95, 82.51 -56.89, -30.87 in-in in 8.792 Saltbr-in 2.667 HRD-in -85.56, -50.77 69.25, 7.31 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.25, 161.18 APE9-dihe-na 110.5, 174.06 APE8-dihe-in -79.35, 133.3 APE8-rot-in 289.14 APE67-dihe-in -66.54, -21.67 -47.06, -45.67 APE12-dist-in 8.042 APE11-dist-in 11.143 APE10-dist-in 5.481 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22694-K3 AGC_PRKACB_HUMAN AGC 6.8e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit beta
AGC PRKACG KAPCG_HUMAN AF-P22612-K1A P22612 36 306 351.0 No_ligand No_ligand Active DFGin 6.055 14.157 BLAminus DFGAsp-rot-in -119.69, -175.0 51.86, 76.25 201.65, 14.24 -82.21, 21.45 280.79, 67.93 -55.81, -32.56 in-in in 8.764 Saltbr-in 2.601 HRD-in -83.71, -50.57 67.08, 0.27 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.95, 164.93 APE9-dihe-na 115.6, -172.56 APE8-dihe-in -103.25, 136.92 APE8-rot-in 300.69 APE67-dihe-in -65.17, -25.87 -48.73, -47.57 APE12-dist-in 8.098 APE11-dist-in 11.44 APE10-dist-in 5.756 APE9-dist-in 3.363 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22612-K1 AGC_PRKACG_HUMAN AGC 2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit gamma
AGC PRKACG KAPCG_HUMAN AF-P22612-K3A P22612 36 306 351.0 No_ligand No_ligand Active DFGin 6.169 13.781 BLAminus DFGAsp-rot-in -129.64, -177.35 52.38, 81.61 201.8, -9.83 -84.7, 15.93 297.94, 93.35 -59.08, -32.02 in-in in 8.838 Saltbr-in 2.618 HRD-in -79.24, -49.45 68.23, -1.8 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.43, 159.7 APE9-dihe-na 111.24, 173.65 APE8-dihe-in -73.65, 132.45 APE8-rot-in 288.98 APE67-dihe-in -66.64, -20.45 -47.52, -46.06 APE12-dist-in 8.211 APE11-dist-in 11.264 APE10-dist-in 5.609 APE9-dist-in 3.651 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22612-K3 AGC_PRKACG_HUMAN AGC 2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit gamma
AGC PRKCA KPCA_HUMAN AF-P17252-K1A P17252 331 605 672.0 No_ligand No_ligand Active DFGin 6.173 13.285 BLAminus DFGAsp-rot-in -134.19, 165.14 67.28, 83.9 200.58, 8.09 -93.09, 16.82 301.84, 90.91 -60.2, -31.47 in-in in 8.702 Saltbr-in 2.65 HRD-in -82.1, -45.11 61.73, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.4, 163.47 APE9-dihe-na 118.86, 165.59 APE8-dihe-in -72.29, 131.08 APE8-rot-in 294.73 APE67-dihe-in -60.18, -26.54 -44.24, -48.61 APE12-dist-in 8.787 APE11-dist-in 12.094 APE10-dist-in 6.517 APE9-dist-in 3.939 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[339, 597]] 1.0 AF-P17252-K1 AGC_PRKCA_HUMAN AGC 1.8e-99 338.0 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN AF-P17252-K3A P17252 331 605 672.0 No_ligand No_ligand Active DFGin 6.225 13.289 BLAminus DFGAsp-rot-in -116.31, -167.6 39.52, 81.02 202.12, 9.08 -87.89, 12.58 300.91, 89.91 -58.46, -29.92 in-in in 8.791 Saltbr-in 2.69 HRD-in -87.62, -44.21 65.44, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 164.78 APE9-dihe-na 116.13, 165.08 APE8-dihe-in -70.89, 133.86 APE8-rot-in 286.57 APE67-dihe-in -59.67, -26.56 -48.45, -48.08 APE12-dist-in 8.697 APE11-dist-in 12.024 APE10-dist-in 6.547 APE9-dist-in 3.501 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[339, 597]] 1.0 AF-P17252-K3 AGC_PRKCA_HUMAN AGC 1.8e-99 338.0 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4A P17252 331 669 672.0 LW4:901 Type1 Active DFGin 6.623 13.818 BLAminus DFGAsp-rot-in -108.9, -177.56 59.08, 89.37 188.08, -24.45 -106.96, 24.06 294.83, 102.31 -75.53, 23.85 in-in in 8.815 Saltbr-in 2.41 HRD-in -74.65, -45.15 57.81, 14.63 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.54, 165.03 APE9-dihe-na 118.37, 165.26 APE8-dihe-in -73.23, 122.76 APE8-rot-in 296.87 APE67-dihe-in -65.34, -19.42 -43.95, -40.88 APE12-dist-in 9.597 APE11-dist-in 12.404 APE10-dist-in 7.198 APE9-dist-in 4.278 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 A 360 332 0 0 0 0 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4B P17252 332 666 672.0 LW4:901 Type1 Active DFGin 6.418 13.305 BLAminus DFGAsp-rot-in -121.94, -178.66 60.88, 102.14 194.72, -21.46 -120.38, 26.83 301.99, 84.51 -64.84, -10.1 in-in in 8.502 Saltbr-in 2.277 HRD-in -77.23, -55.63 71.28, 15.73 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.82, 155.18 APE9-dihe-na 134.69, -179.0 APE8-dihe-in -84.78, 118.85 APE8-rot-in 310.63 APE67-dihe-in -51.46, -22.6 -31.15, -62.66 APE12-dist-in 9.67 APE11-dist-in 12.179 APE10-dist-in 6.955 APE9-dist-in 3.906 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 B 360 327 1 0 0 1 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4C P17252 330 670 672.0 LW4:901 Type1 Active DFGin 6.462 13.422 BLAminus DFGAsp-rot-in -141.95, -178.5 58.36, 93.1 173.38, 5.8 -108.43, 30.26 303.23, 90.16 -75.14, 20.66 in-in in 8.688 Saltbr-in 2.568 HRD-in -74.14, -54.37 68.8, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.97, 175.07 APE9-dihe-na 106.85, 167.92 APE8-dihe-in -78.66, 121.4 APE8-rot-in 308.52 APE67-dihe-in -55.88, -21.85 -44.2, -44.83 APE12-dist-in 9.978 APE11-dist-in 12.209 APE10-dist-in 6.918 APE9-dist-in 4.275 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 C 360 334 0 0 0 0 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 8U37A P17252 332 666 672.0 V5U:701 Type1 Active DFGin 6.456 13.982 BLAminus DFGAsp-rot-in -124.67, 166.89 71.84, 85.0 194.0, -3.05 -101.61, 23.28 297.19, 92.03 -74.96, -6.46 in-in in 9.247 Saltbr-in 2.92 HRD-in -83.79, -50.86 64.48, 14.73 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.97, 164.54 APE9-dihe-na 123.96, -175.11 APE8-dihe-in -105.91, 130.22 APE8-rot-in 295.66 APE67-dihe-in -58.49, -24.13 -40.33, -55.15 APE12-dist-in 8.912 APE11-dist-in 11.978 APE10-dist-in 6.465 APE9-dist-in 3.97 D463N,V568I,S657E TPO497,TPO638 TPO497,TPO638 XRAY 2.48 0.22 0.258 A 354 320 0 0 0 0 [[339, 597]] 1.0 8u37 AGC_PRKCA_HUMAN AGC 4.8e-98 333.4 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 8UAKA P17252 332 666 672.0 W39:701 Type1 Active DFGin 6.212 13.741 BLAminus DFGAsp-rot-in -125.08, 168.12 72.21, 85.43 197.06, -8.27 -101.49, 23.86 298.05, 92.55 -75.06, -6.75 in-in in 8.95 Saltbr-in 3.138 HRD-in -83.28, -49.78 64.18, 14.31 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.06, 166.71 APE9-dihe-na 125.31, -174.75 APE8-dihe-in -105.85, 130.44 APE8-rot-in 299.2 APE67-dihe-in -58.77, -23.31 -39.4, -55.69 APE12-dist-in 8.681 APE11-dist-in 12.011 APE10-dist-in 6.429 APE9-dist-in 3.766 D463N,V568I,S657E TPO497,TPO638 TPO497,TPO638 XRAY 2.82 0.208 0.243 A 354 319 0 0 0 0 [[339, 597]] 1.0 8uak AGC_PRKCA_HUMAN AGC 4.8e-98 333.4 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus DFGAsp-rot-in -130.5, -169.38 54.07, 70.37 192.19, 7.48 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus DFGAsp-rot-in -130.75, -169.0 53.85, 70.09 192.17, 8.08 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus DFGAsp-rot-in -122.79, -175.57 50.54, 85.22 197.04, -8.87 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN AF-P05771-K1A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.973 13.023 BLAminus DFGAsp-rot-in -104.35, -161.36 27.53, 84.09 204.83, 11.56 -90.04, 16.15 301.5, 91.82 -59.68, -29.78 in-in in 8.617 Saltbr-in 2.673 HRD-in -85.78, -46.1 64.58, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.82, 162.82 APE9-dihe-na 121.92, 167.13 APE8-dihe-in -72.73, 133.23 APE8-rot-in 298.5 APE67-dihe-in -66.05, -23.0 -49.76, -45.57 APE12-dist-in 8.607 APE11-dist-in 11.905 APE10-dist-in 6.229 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K1 AGC_PRKCB_HUMAN AGC 1.2e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN AF-P05771-K3A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.745 13.195 BLAminus DFGAsp-rot-in -110.85, -172.96 35.96, 94.12 207.07, -18.32 -98.35, 13.42 304.83, 99.89 -60.51, -33.43 in-in in 8.348 Saltbr-in 2.666 HRD-in -84.51, -47.08 65.34, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.41, 161.65 APE9-dihe-na 129.21, 169.52 APE8-dihe-in -83.16, 130.6 APE8-rot-in 297.23 APE67-dihe-in -58.28, -24.56 -44.92, -51.84 APE12-dist-in 8.731 APE11-dist-in 11.81 APE10-dist-in 6.251 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K3 AGC_PRKCB_HUMAN AGC 1.2e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 2I0EB P05771 339 668 671.0 PDS:60902 Type1 Active DFGin 6.906 13.595 BLAminus DFGAsp-rot-in -122.54, 163.63 74.87, 90.26 203.8, -3.99 -109.7, 30.33 301.59, 90.18 -89.33, 11.84 in-in in 9.025 Saltbr-in 2.821 HRD-in -82.04, -48.12 70.57, -0.74 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.03, 175.5 APE9-dihe-na 106.77, 155.55 APE8-dihe-in -68.48, 122.99 APE8-rot-in 298.97 APE67-dihe-in -65.65, -22.82 -42.1, -37.43 APE12-dist-in 8.683 APE11-dist-in 12.143 APE10-dist-in 6.729 APE9-dist-in 3.821 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 B 353 300 0 0 0 0 [[342, 600]] 1.0 2i0e AGC_PRKCB_HUMAN AGC 2.8e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCD KPCD_HUMAN AF-Q05655-K1A Q05655 341 611 676.0 No_ligand No_ligand Active DFGin 5.762 12.98 BLAminus DFGAsp-rot-in -108.87, -152.19 13.42, 84.55 204.41, 7.87 -85.99, 14.4 304.74, 97.93 -60.65, -27.31 in-in in 8.509 Saltbr-in 2.606 HRD-in -83.86, -47.35 64.43, -6.23 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.85, 159.33 APE9-dihe-na 127.37, 165.29 APE8-dihe-in -67.93, 133.61 APE8-rot-in 296.68 APE67-dihe-in -66.15, -22.37 -49.15, -47.86 APE12-dist-in 8.746 APE11-dist-in 11.982 APE10-dist-in 6.38 APE9-dist-in 3.397 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[349, 603]] 1.0 AF-Q05655-K1 AGC_PRKCD_HUMAN AGC 9.9e-93 315.9 1 260 260 490 491 492 494 496 378 397 401 470 472 471 473 530 518 513 512 511 510 509 508 507 428 Protein kinase C delta type
AGC PRKCD KPCD_HUMAN AF-Q05655-K3A Q05655 341 611 676.0 No_ligand No_ligand Active DFGin 5.585 13.044 BLAminus DFGAsp-rot-in -116.86, -177.83 45.18, 84.72 209.8, -15.32 -91.11, 13.43 306.23, 100.59 -59.29, -31.35 in-in in 8.312 Saltbr-in 2.657 HRD-in -81.53, -47.84 67.21, 0.35 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.66, 159.14 APE9-dihe-na 133.74, 168.34 APE8-dihe-in -79.24, 131.18 APE8-rot-in 294.95 APE67-dihe-in -58.09, -22.52 -44.39, -53.02 APE12-dist-in 8.693 APE11-dist-in 11.788 APE10-dist-in 6.219 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[349, 603]] 1.0 AF-Q05655-K3 AGC_PRKCD_HUMAN AGC 9.9e-93 315.9 1 260 260 490 491 492 494 496 378 397 401 470 472 471 473 530 518 513 512 511 510 509 508 507 428 Protein kinase C delta type
AGC PRKCE KPCE_HUMAN AF-Q02156-K1A Q02156 400 676 737.0 No_ligand No_ligand Active DFGin 5.76 12.789 BLAminus DFGAsp-rot-in -109.14, -174.81 42.5, 79.36 205.62, 6.1 -85.06, 16.43 303.93, 96.39 -63.79, -28.29 in-in in 8.728 Saltbr-in 2.692 HRD-in -84.34, -46.8 62.89, 1.98 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.52, 164.55 APE9-dihe-na 130.34, 177.4 APE8-dihe-in -87.15, 127.62 APE8-rot-in 296.09 APE67-dihe-in -64.76, -22.51 -47.37, -45.68 APE12-dist-in 8.909 APE11-dist-in 11.876 APE10-dist-in 6.222 APE9-dist-in 3.449 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[408, 668]] 1.0 AF-Q02156-K1 AGC_PRKCE_HUMAN AGC 7.3e-100 339.3 1 260 260 549 550 551 553 555 437 456 460 529 531 530 532 589 577 572 571 570 569 568 567 566 487 Protein kinase C epsilon type
AGC PRKCE KPCE_HUMAN AF-Q02156-K3A Q02156 400 676 737.0 No_ligand No_ligand Active DFGin 5.779 12.705 BLAminus DFGAsp-rot-in -119.92, 177.83 55.03, 75.07 204.48, 0.28 -88.27, 15.42 307.81, 102.74 -68.02, -28.02 in-in in 8.299 Saltbr-in 2.731 HRD-in -85.36, -48.33 64.74, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.67, 163.72 APE9-dihe-na 137.29, 172.07 APE8-dihe-in -87.55, 129.61 APE8-rot-in 294.41 APE67-dihe-in -58.17, -22.63 -44.36, -52.53 APE12-dist-in 8.898 APE11-dist-in 11.747 APE10-dist-in 6.206 APE9-dist-in 3.412 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[408, 668]] 1.0 AF-Q02156-K3 AGC_PRKCE_HUMAN AGC 7.3e-100 339.3 1 260 260 549 550 551 553 555 437 456 460 529 531 530 532 589 577 572 571 570 569 568 567 566 487 Protein kinase C epsilon type
AGC PRKCG KPCG_HUMAN AF-P05129-K1A P05129 343 622 697.0 No_ligand No_ligand Active DFGin 6.105 12.952 BLAminus DFGAsp-rot-in -111.37, -152.57 16.87, 87.61 202.66, 9.05 -91.31, 13.91 302.66, 90.5 -59.22, -30.54 in-in in 8.569 Saltbr-in 2.688 HRD-in -83.15, -45.84 63.41, -0.56 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.46, 165.12 APE9-dihe-na 116.59, 162.28 APE8-dihe-in -64.96, 134.05 APE8-rot-in 287.01 APE67-dihe-in -65.51, -23.33 -48.83, -46.67 APE12-dist-in 8.64 APE11-dist-in 11.898 APE10-dist-in 6.241 APE9-dist-in 3.459 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[351, 614]] 1.0 AF-P05129-K1 AGC_PRKCG_HUMAN AGC 2.4e-93 317.9 1 260 260 497 498 499 501 503 380 399 403 477 479 478 480 537 525 520 519 518 517 516 515 514 435 Protein kinase C gamma type
AGC PRKCG KPCG_HUMAN AF-P05129-K3A P05129 343 622 697.0 No_ligand No_ligand Active DFGin 6.162 13.252 BLAminus DFGAsp-rot-in -108.58, -167.98 34.6, 86.68 203.33, -1.32 -90.71, 13.96 301.23, 91.08 -61.22, -32.03 in-in in 8.68 Saltbr-in 2.626 HRD-in -84.75, -46.91 68.8, 2.98 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.3, 168.77 APE9-dihe-na 113.09, 167.53 APE8-dihe-in -80.1, 133.75 APE8-rot-in 300.08 APE67-dihe-in -59.0, -24.44 -48.22, -50.17 APE12-dist-in 8.519 APE11-dist-in 11.869 APE10-dist-in 6.272 APE9-dist-in 3.378 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[351, 614]] 1.0 AF-P05129-K3 AGC_PRKCG_HUMAN AGC 2.4e-93 317.9 1 260 260 497 498 499 501 503 380 399 403 477 479 478 480 537 525 520 519 518 517 516 515 514 435 Protein kinase C gamma type
AGC PRKCH KPCL_HUMAN AF-P24723-K1A P24723 347 622 683.0 No_ligand No_ligand Active DFGin 5.749 12.772 BLAminus DFGAsp-rot-in -106.1, -173.16 38.28, 91.09 206.39, -2.31 -97.14, 16.07 304.8, 94.12 -62.68, -25.89 in-in in 8.525 Saltbr-in 2.617 HRD-in -85.22, -48.7 63.75, -0.17 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.59, 159.8 APE9-dihe-na 134.84, 173.72 APE8-dihe-in -79.82, 127.49 APE8-rot-in 296.6 APE67-dihe-in -67.71, -17.85 -43.24, -50.27 APE12-dist-in 8.71 APE11-dist-in 11.608 APE10-dist-in 5.964 APE9-dist-in 3.432 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[355, 614]] 1.0 AF-P24723-K1 AGC_PRKCH_HUMAN AGC 7.1e-98 332.8 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN AF-P24723-K3A P24723 347 622 683.0 No_ligand No_ligand Active DFGin 5.486 12.838 BLAminus DFGAsp-rot-in -113.3, -173.79 33.92, 96.43 208.65, -6.72 -97.69, 15.91 306.27, 99.4 -63.08, -28.8 in-in in 8.388 Saltbr-in 2.625 HRD-in -87.28, -49.72 68.32, -5.12 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.76, 163.25 APE9-dihe-na 130.19, 175.68 APE8-dihe-in -87.39, 133.47 APE8-rot-in 293.76 APE67-dihe-in -64.49, -20.83 -48.29, -47.55 APE12-dist-in 8.681 APE11-dist-in 11.638 APE10-dist-in 6.033 APE9-dist-in 3.433 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[355, 614]] 1.0 AF-P24723-K3 AGC_PRKCH_HUMAN AGC 7.1e-98 332.8 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.04 12.861 BLAminus DFGAsp-rot-in -134.17, 160.39 76.6, 103.68 196.33, -14.99 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.529 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.666 APE11-dist-in 11.701 APE10-dist-in 6.365 APE9-dist-in 3.566 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353 328 0 0 0 0 [[355, 614]] 1.0 8fp1 AGC_PRKCH_HUMAN AGC 1.7e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN 8FP3A P24723 349 679 683.0 Y3I:9000 Type1 Active DFGin 6.22 13.226 BLAminus DFGAsp-rot-in -127.87, 165.42 68.91, 93.86 200.87, -5.67 -107.42, 16.9 300.66, 99.02 -64.47, -31.74 in-in in 8.835 Saltbr-in 2.953 HRD-in -62.84, -58.95 67.06, -3.18 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.98, 170.15 APE9-dihe-na 118.17, 177.41 APE8-dihe-in -88.28, 125.69 APE8-rot-in 312.19 APE67-dihe-in -66.78, -22.74 -44.71, -43.76 APE12-dist-in 8.702 APE11-dist-in 11.681 APE10-dist-in 6.178 APE9-dist-in 3.426 S675E TPO513,TPO656 TPO513,TPO656 XRAY 2.3 0.198 0.256 A 353 331 0 0 0 0 [[355, 614]] 1.0 8fp3 AGC_PRKCH_HUMAN AGC 1.7e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.403 11.863 BLAminus DFGAsp-rot-in -129.58, 178.7 63.64, 84.98 184.94, 11.75 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.178 Saltbr-in 3.031 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.986 APE10-dist-in 5.421 APE9-dist-in 3.56 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349 326 15 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.31 11.876 BLAminus DFGAsp-rot-in -129.18, 178.42 63.46, 84.62 184.86, 11.73 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.72 Saltbr-in 2.545 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.329 APE11-dist-in 11.256 APE10-dist-in 5.693 APE9-dist-in 3.742 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349 320 20 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.635 12.633 BLAminus DFGAsp-rot-in -139.17, 172.4 72.31, 78.11 201.72, -12.7 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.361 Saltbr-in 2.614 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.812 APE11-dist-in 11.949 APE10-dist-in 6.432 APE9-dist-in 3.836 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350 330 12 0 0 0 [[254, 522]] 1.0 5li9 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.079 11.961 BLAminus DFGAsp-rot-in -129.24, 176.98 73.22, 90.17 187.2, 4.73 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.816 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.752 APE11-dist-in 11.822 APE10-dist-in 6.31 APE9-dist-in 3.517 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354 332 10 0 0 0 [[254, 522]] 1.0 5li1 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN AF-P41743-K1A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.447 12.405 BLAminus DFGAsp-rot-in -131.03, -165.82 44.28, 65.55 207.94, 24.01 -76.76, 9.18 306.63, 118.08 -56.74, -36.72 in-in in 8.45 Saltbr-in 2.623 HRD-in -77.0, -41.44 60.49, -7.42 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.06, 173.77 APE9-dihe-na 111.64, 163.54 APE8-dihe-in -68.62, 127.52 APE8-rot-in 295.24 APE67-dihe-in -71.1, -16.65 -47.7, -40.44 APE12-dist-in 8.652 APE11-dist-in 11.892 APE10-dist-in 6.185 APE9-dist-in 3.578 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[254, 522]] 1.0 AF-P41743-K1 AGC_PRKCI_HUMAN AGC 5.7e-96 326.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN AF-P41743-K3A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.067 12.263 BLAminus DFGAsp-rot-in -132.42, 177.52 58.72, 87.78 207.01, 0.36 -95.71, 10.36 309.96, 125.27 -59.78, -23.56 in-in in 8.434 Saltbr-in 2.609 HRD-in -81.78, -44.52 65.41, -3.76 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.16, 168.09 APE9-dihe-na 113.77, 166.26 APE8-dihe-in -77.9, 128.97 APE8-rot-in 291.1 APE67-dihe-in -65.12, -20.54 -47.59, -43.64 APE12-dist-in 8.77 APE11-dist-in 11.646 APE10-dist-in 6.116 APE9-dist-in 3.269 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[254, 522]] 1.0 AF-P41743-K3 AGC_PRKCI_HUMAN AGC 5.7e-96 326.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8XA P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.479 12.306 BLAminus DFGAsp-rot-in -133.56, 171.16 66.18, 84.73 191.3, -29.14 -94.69, 12.13 305.3, 131.59 -63.13, -17.58 in-in in 8.784 Saltbr-in 2.575 HRD-in -71.12, -56.95 73.87, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.63, 123.28 APE9-dihe-na 133.81, -165.17 APE8-dihe-in -100.11, 125.82 APE8-rot-in 300.75 APE67-dihe-in -55.67, -25.11 -46.23, -50.55 APE12-dist-in 8.534 APE11-dist-in 11.685 APE10-dist-in 6.739 APE9-dist-in 3.798 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 A 345 333 7 0 0 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8XB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.196 12.363 BLAminus DFGAsp-rot-in -134.81, 172.86 61.29, 86.65 182.43, -6.13 -89.58, 25.14 305.87, 129.78 -77.51, -26.88 in-in in 8.854 Saltbr-in 3.141 HRD-in -71.84, -53.34 75.49, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.8, 129.32 APE9-dihe-na 125.34, -174.85 APE8-dihe-in -94.58, 120.99 APE8-rot-in 296.51 APE67-dihe-in -60.75, -26.64 -37.16, -45.74 APE12-dist-in 8.85 APE11-dist-in 11.874 APE10-dist-in 6.855 APE9-dist-in 3.878 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 B 345 327 13 0 0 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJKB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 6.322 12.883 BLAminus DFGAsp-rot-in -140.76, 171.15 65.08, 85.19 184.74, 1.57 -104.47, 31.46 313.7, 135.04 -76.2, -15.07 in-in in 9.004 Saltbr-in 3.533 HRD-in -63.1, -53.44 69.1, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.455 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 154.63 APE9-dihe-na 128.06, 155.44 APE8-dihe-in -56.67, 121.19 APE8-rot-in 310.7 APE67-dihe-in -58.25, -24.63 -54.37, -39.36 APE12-dist-in 9.377 APE11-dist-in 12.385 APE10-dist-in 6.726 APE9-dist-in 4.126 None TPO412,TPO564 TPO412,TPO564 EM 3.08 999.0 999.0 B 596 320 9 0 0 0 [[254, 522]] 1.0 9ejk AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJLB P41743 25 588 596.0 No_ligand No_ligand Active DFGin 5.78 13.01 BLAminus DFGAsp-rot-in -138.05, 176.56 63.52, 82.24 184.24, 1.31 -100.53, 29.28 318.31, 120.09 -73.2, -15.29 in-in in 8.71 Saltbr-in 3.107 HRD-in -63.42, -52.9 69.14, -4.84 in-in-in SNCiii in-in ActLoopNT-in 3.39 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.27, 154.98 APE9-dihe-na 129.08, 155.07 APE8-dihe-in -56.55, 121.43 APE8-rot-in 311.13 APE67-dihe-in -59.47, -23.97 -53.96, -40.11 APE12-dist-in 9.615 APE11-dist-in 12.402 APE10-dist-in 6.733 APE9-dist-in 4.127 None TPO412,TPO564 TPO412,TPO564 EM 3.48 999.0 999.0 B 596 506 0 0 0 0 [[254, 522]] 1.0 9ejl AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8A P41743 248 590 596.0 C58:61582 Type1 Active DFGin 5.556 12.002 BLAminus DFGAsp-rot-in -130.37, -178.04 51.18, 83.54 180.62, 17.37 -87.27, 17.91 304.14, 111.3 -61.33, -13.38 in-in in 9.325 Saltbr-in 3.341 HRD-in -65.53, -55.38 66.64, 24.69 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 178.63 APE9-dihe-na 118.81, -170.03 APE8-dihe-in -107.2, 114.73 APE8-rot-in 305.39 APE67-dihe-in -50.56, -25.42 -31.13, -57.8 APE12-dist-in 8.723 APE11-dist-in 11.789 APE10-dist-in 6.195 APE9-dist-in 3.857 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 A 349 320 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8B P41743 248 589 596.0 C58:61581 Type1 Active DFGin 5.505 12.036 BLAminus DFGAsp-rot-in -129.65, -179.53 51.29, 82.99 180.55, 17.08 -86.76, 19.25 305.39, 112.3 -61.07, -14.24 in-in in 9.33 Saltbr-in 3.256 HRD-in -64.76, -55.3 66.61, 24.25 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, 178.62 APE9-dihe-na 117.31, -170.26 APE8-dihe-in -107.45, 114.14 APE8-rot-in 306.11 APE67-dihe-in -50.63, -24.48 -30.49, -58.16 APE12-dist-in 8.839 APE11-dist-in 11.985 APE10-dist-in 6.37 APE9-dist-in 3.864 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 B 349 319 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8C P41743 248 588 596.0 C58:61580 Type1 Active DFGin 5.796 12.073 BLAminus DFGAsp-rot-in -128.69, -178.25 53.53, 81.54 180.64, 17.88 -88.45, 18.44 303.41, 111.5 -61.77, -13.25 in-in in 9.367 Saltbr-in 3.275 HRD-in -64.18, -55.09 66.76, 24.05 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.52, 178.89 APE9-dihe-na 116.26, -170.7 APE8-dihe-in -106.06, 114.81 APE8-rot-in 304.72 APE67-dihe-in -49.82, -25.77 -29.67, -57.17 APE12-dist-in 8.928 APE11-dist-in 11.778 APE10-dist-in 6.17 APE9-dist-in 3.786 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 C 349 314 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 1ZRZA P41743 249 588 596.0 BI1:61000 Type1 Active DFGin 5.407 12.571 BLAminus DFGAsp-rot-in -130.8, 174.67 64.45, 118.73 183.45, -58.03 -128.08, 29.21 300.88, 154.48 -95.06, 36.97 in-in in 8.489 Saltbr-in 2.773 HRD-in -48.25, -53.67 63.34, -15.36 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.12, -165.87 APE9-dihe-na 92.97, 155.51 APE8-dihe-in -67.22, 110.52 APE8-rot-in 321.88 APE67-dihe-in -51.87, -24.47 -26.14, -57.0 APE12-dist-in 8.399 APE11-dist-in 11.824 APE10-dist-in 6.456 APE9-dist-in 3.789 None TPO412,TPO564 TPO412,TPO564 XRAY 3.0 0.249 0.333 A 364 312 9 0 0 0 [[254, 522]] 1.0 1zrz AGC_PRKCI_HUMAN AGC 2.5e-95 324.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCQ KPCT_HUMAN AF-Q04759-K1A Q04759 372 642 706.0 No_ligand No_ligand Active DFGin 5.888 13.092 BLAminus DFGAsp-rot-in -111.47, -161.58 28.49, 81.48 202.79, 9.55 -87.29, 15.51 303.95, 98.21 -58.98, -28.73 in-in in 8.489 Saltbr-in 2.611 HRD-in -79.51, -46.72 64.6, -6.08 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.83, 164.71 APE9-dihe-na 120.22, 165.8 APE8-dihe-in -69.46, 133.57 APE8-rot-in 297.66 APE67-dihe-in -68.66, -21.56 -49.68, -45.16 APE12-dist-in 8.698 APE11-dist-in 12.045 APE10-dist-in 6.447 APE9-dist-in 3.501 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[380, 634]] 1.0 AF-Q04759-K1 AGC_PRKCQ_HUMAN AGC 5.2e-96 326.7 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN AF-Q04759-K3A Q04759 372 642 706.0 No_ligand No_ligand Active DFGin 5.719 13.112 BLAminus DFGAsp-rot-in -115.41, 178.48 45.7, 90.34 205.98, -12.57 -95.22, 12.74 305.99, 102.65 -59.82, -31.49 in-in in 8.395 Saltbr-in 2.63 HRD-in -80.31, -47.4 66.14, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, 163.76 APE9-dihe-na 124.04, 165.42 APE8-dihe-in -77.47, 131.1 APE8-rot-in 294.41 APE67-dihe-in -61.12, -22.91 -45.2, -50.91 APE12-dist-in 8.834 APE11-dist-in 11.702 APE10-dist-in 6.141 APE9-dist-in 3.332 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[380, 634]] 1.0 AF-Q04759-K3 AGC_PRKCQ_HUMAN AGC 5.2e-96 326.7 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 2JEDA Q04759 375 700 706.0 LG8:61701 Type1 Active DFGin 6.614 13.667 BLAminus DFGAsp-rot-in -113.39, 165.43 67.55, 92.49 205.96, -25.95 -102.81, 25.08 299.09, 96.04 -77.76, -4.74 in-in in 8.698 Saltbr-in 3.201 HRD-in -82.61, -46.83 69.15, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.64, 141.45 APE9-dihe-na 144.48, -176.42 APE8-dihe-in -112.96, 132.15 APE8-rot-in 286.91 APE67-dihe-in -65.19, -26.4 -40.31, -53.61 APE12-dist-in 8.797 APE11-dist-in 11.75 APE10-dist-in 5.962 APE9-dist-in 3.883 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.32 0.188 0.221 A 352 326 0 0 0 0 [[380, 634]] 1.0 2jed AGC_PRKCQ_HUMAN AGC 6.5e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 2JEDB Q04759 375 706 706.0 LG8:61712 Type1 Active DFGin 6.477 13.775 BLAminus DFGAsp-rot-in -116.9, 164.62 69.71, 89.68 205.74, -25.34 -101.74, 24.61 303.13, 88.06 -65.56, -17.66 in-in in 8.91 Saltbr-in 3.02 HRD-in -77.46, -49.1 72.97, -12.75 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.05, 132.52 APE9-dihe-na 123.41, 168.41 APE8-dihe-in -74.67, 129.81 APE8-rot-in 290.27 APE67-dihe-in -53.63, -32.33 -43.76, -48.79 APE12-dist-in 8.773 APE11-dist-in 11.68 APE10-dist-in 6.647 APE9-dist-in 4.1 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.32 0.188 0.221 B 352 317 0 0 0 0 [[380, 634]] 1.0 2jed AGC_PRKCQ_HUMAN AGC 6.5e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 5F9EA Q04759 374 706 706.0 5VS:61001 Type1 Active DFGin 6.476 13.852 BLAminus DFGAsp-rot-in -124.47, 161.09 72.18, 90.67 193.54, -5.54 -101.4, 15.51 297.35, 95.13 -63.75, -26.0 in-in in 9.058 Saltbr-in 2.717 HRD-in -81.15, -47.98 73.24, -5.11 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.97, 169.63 APE9-dihe-na 131.49, -173.01 APE8-dihe-in -109.76, 129.84 APE8-rot-in 295.69 APE67-dihe-in -61.77, -26.26 -46.68, -44.42 APE12-dist-in 8.954 APE11-dist-in 12.017 APE10-dist-in 6.561 APE9-dist-in 3.659 None SEP676,SEP695 SEP676,SEP695 XRAY 2.0 0.199 0.233 A 353 333 0 0 0 0 [[380, 634]] 1.0 5f9e AGC_PRKCQ_HUMAN AGC 6.6e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 5F9EB Q04759 375 700 706.0 5VS:61001 Type1 Active DFGin 6.583 13.885 BLAminus DFGAsp-rot-in -118.45, 165.26 62.54, 88.94 193.49, -6.25 -98.52, 15.46 302.93, 89.41 -59.36, -22.06 in-in in 9.267 Saltbr-in 2.59 HRD-in -84.26, -45.13 71.76, -7.56 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.19, 135.47 APE9-dihe-na 127.82, -166.17 APE8-dihe-in -112.12, 133.27 APE8-rot-in 297.56 APE67-dihe-in -57.44, -27.74 -44.31, -54.84 APE12-dist-in 8.768 APE11-dist-in 12.046 APE10-dist-in 7.323 APE9-dist-in 3.578 None SEP676,SEP695 SEP676,SEP695 XRAY 2.0 0.199 0.233 B 353 294 0 0 0 0 [[380, 634]] 1.0 5f9e AGC_PRKCQ_HUMAN AGC 6.6e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.828 13.193 BLAminus DFGAsp-rot-in -132.69, 162.8 69.28, 95.13 199.49, -20.4 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.064 Saltbr-in 2.513 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.03 APE11-dist-in 12.294 APE10-dist-in 6.896 APE9-dist-in 3.767 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345 282 0 0 0 0 [[380, 634]] 1.0 1xjd AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCZ KPCZ_HUMAN AF-Q05513-K1A Q05513 244 526 592.0 No_ligand No_ligand Active DFGin 5.247 12.248 BLAminus DFGAsp-rot-in -134.19, -169.05 47.75, 68.43 205.19, 24.54 -79.67, 13.11 309.63, 113.67 -62.25, -19.27 in-in in 8.664 Saltbr-in 2.594 HRD-in -77.28, -43.6 62.88, -6.04 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.51, 169.63 APE9-dihe-na 112.85, 164.61 APE8-dihe-in -71.33, 130.47 APE8-rot-in 295.97 APE67-dihe-in -66.67, -18.73 -48.34, -43.82 APE12-dist-in 8.54 APE11-dist-in 11.753 APE10-dist-in 6.085 APE9-dist-in 3.588 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[252, 518]] 1.0 AF-Q05513-K1 AGC_PRKCZ_HUMAN AGC 4.3e-94 320.4 1 260 260 393 394 395 397 399 281 300 304 373 375 374 376 433 421 416 415 414 413 412 411 410 331 Protein kinase C zeta type
AGC PRKCZ KPCZ_HUMAN AF-Q05513-K3A Q05513 244 526 592.0 No_ligand No_ligand Active DFGin 5.121 12.155 BLAminus DFGAsp-rot-in -132.86, -176.33 58.74, 76.35 202.54, 23.99 -87.97, 8.87 310.28, 134.34 -62.38, -20.23 in-in in 8.478 Saltbr-in 2.638 HRD-in -83.8, -41.61 66.03, -3.98 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 173.93 APE9-dihe-na 108.79, 169.21 APE8-dihe-in -80.7, 127.66 APE8-rot-in 291.97 APE67-dihe-in -62.23, -21.3 -45.38, -45.91 APE12-dist-in 8.892 APE11-dist-in 11.838 APE10-dist-in 6.182 APE9-dist-in 3.324 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[252, 518]] 1.0 AF-Q05513-K3 AGC_PRKCZ_HUMAN AGC 4.3e-94 320.4 1 260 260 393 394 395 397 399 281 300 304 373 375 374 376 433 421 416 415 414 413 412 411 410 331 Protein kinase C zeta type
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.811 14.714 BLAminus DFGAsp-rot-in -124.15, 169.14 66.07, 88.5 189.42, -2.31 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.522 Saltbr-in 2.883 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.235 APE11-dist-in 11.512 APE10-dist-in 6.041 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347 336 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.001 13.81 BLAminus DFGAsp-rot-in -122.67, 175.58 65.94, 84.43 190.65, 1.3 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.743 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.826 APE11-dist-in 11.215 APE10-dist-in 5.769 APE9-dist-in 4.008 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347 326 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.746 14.057 BLAminus DFGAsp-rot-in -122.99, 175.03 65.66, 84.22 189.65, 1.38 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.742 Saltbr-in 2.723 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.972 APE11-dist-in 11.385 APE10-dist-in 5.857 APE9-dist-in 3.861 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347 335 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.71 14.012 BLAminus DFGAsp-rot-in -124.49, 174.79 65.67, 84.87 190.77, 1.27 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.644 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.988 APE11-dist-in 11.327 APE10-dist-in 5.784 APE9-dist-in 3.81 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347 328 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.851 14.036 BLAminus DFGAsp-rot-in -116.97, 177.04 63.26, 88.72 193.0, 2.14 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.624 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.972 APE11-dist-in 11.057 APE10-dist-in 5.469 APE9-dist-in 3.811 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617 600 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.634 13.962 BLAminus DFGAsp-rot-in -116.52, 178.28 63.3, 90.17 189.2, 6.59 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.883 Saltbr-in 2.824 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.134 APE11-dist-in 11.198 APE10-dist-in 5.604 APE9-dist-in 3.787 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617 593 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN AF-Q13976-K1A Q13976 352 627 671.0 No_ligand No_ligand Active DFGin 6.271 14.18 BLAminus DFGAsp-rot-in -115.7, -171.89 41.6, 86.13 204.02, -3.4 -92.63, 18.96 285.01, 78.59 -59.54, -30.9 in-in in 9.607 Saltbr-in 2.712 HRD-in -90.69, -50.22 66.05, 7.72 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.15, 172.71 APE9-dihe-na 108.43, 171.02 APE8-dihe-in -80.49, 129.57 APE8-rot-in 300.74 APE67-dihe-in -68.04, -21.28 -48.8, -41.85 APE12-dist-in 8.214 APE11-dist-in 11.197 APE10-dist-in 5.629 APE9-dist-in 3.53 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[360, 619]] 1.0 AF-Q13976-K1 AGC_PRKG1_HUMAN AGC 1.2e-84 289.4 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN AF-Q13976-K3A Q13976 352 627 671.0 No_ligand No_ligand Active DFGin 5.906 13.923 BLAminus DFGAsp-rot-in -115.45, -173.31 41.39, 87.3 204.92, 2.57 -90.8, 19.58 282.99, 76.21 -58.78, -31.1 in-in in 9.248 Saltbr-in 2.714 HRD-in -91.17, -53.27 69.22, 14.91 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.96, 169.62 APE9-dihe-na 104.72, 167.78 APE8-dihe-in -75.94, 135.6 APE8-rot-in 283.37 APE67-dihe-in -66.68, -21.92 -49.58, -45.16 APE12-dist-in 7.888 APE11-dist-in 11.013 APE10-dist-in 5.444 APE9-dist-in 3.338 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[360, 619]] 1.0 AF-Q13976-K3 AGC_PRKG1_HUMAN AGC 1.2e-84 289.4 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG2 KGP2_HUMAN AF-Q13237-K1A Q13237 445 719 762.0 No_ligand No_ligand Active DFGin 6.752 14.082 BLAminus DFGAsp-rot-in -119.48, -168.56 40.28, 72.03 204.36, 20.64 -81.07, 22.48 279.52, 70.99 -61.25, -29.42 in-in in 9.097 Saltbr-in 2.634 HRD-in -88.44, -50.44 65.17, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.09, 174.87 APE9-dihe-na 104.38, 165.11 APE8-dihe-in -75.18, 129.23 APE8-rot-in 301.17 APE67-dihe-in -67.52, -20.75 -48.21, -43.33 APE12-dist-in 7.965 APE11-dist-in 11.192 APE10-dist-in 5.565 APE9-dist-in 3.516 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[453, 711]] 1.0 AF-Q13237-K1 AGC_PRKG2_HUMAN AGC 3.4e-83 284.7 2 259 258 593 594 595 597 599 482 501 505 573 575 574 576 632 620 615 614 613 612 611 610 609 531 cGMP-dependent protein kinase 2
AGC PRKG2 KGP2_HUMAN AF-Q13237-K3A Q13237 445 719 762.0 No_ligand No_ligand Active DFGin 6.502 14.153 BLAminus DFGAsp-rot-in -125.77, -178.87 48.72, 84.0 207.66, 5.43 -89.45, 17.56 282.99, 76.2 -58.9, -27.76 in-in in 9.096 Saltbr-in 2.644 HRD-in -88.18, -50.21 69.86, 1.4 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.03, 171.58 APE9-dihe-na 102.04, 166.89 APE8-dihe-in -72.95, 132.54 APE8-rot-in 286.13 APE67-dihe-in -67.36, -20.13 -48.32, -44.14 APE12-dist-in 7.685 APE11-dist-in 10.986 APE10-dist-in 5.484 APE9-dist-in 3.725 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[453, 711]] 1.0 AF-Q13237-K3 AGC_PRKG2_HUMAN AGC 3.4e-83 284.7 2 259 258 593 594 595 597 599 482 501 505 573 575 574 576 632 620 615 614 613 612 611 610 609 531 cGMP-dependent protein kinase 2
AGC PRKX PRKX_HUMAN AF-P51817-K1A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.667 14.553 BLAminus DFGAsp-rot-in -121.72, -174.69 49.59, 81.61 199.0, -12.13 -95.04, 16.66 288.42, 82.22 -70.51, -23.61 in-in in 8.911 Saltbr-in 2.708 HRD-in -86.78, -47.49 65.73, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.15, 159.34 APE9-dihe-na 109.64, 178.29 APE8-dihe-in -81.97, 127.99 APE8-rot-in 303.22 APE67-dihe-in -65.66, -24.04 -47.75, -43.09 APE12-dist-in 8.315 APE11-dist-in 11.312 APE10-dist-in 5.621 APE9-dist-in 3.592 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K1 AGC_PRKX_HUMAN AGC 5.6e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
AGC PRKX PRKX_HUMAN AF-P51817-K3A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.24 14.365 BLAminus DFGAsp-rot-in -126.23, -173.14 47.02, 78.73 201.67, -14.04 -87.6, 16.57 289.31, 79.51 -57.8, -34.93 in-in in 8.808 Saltbr-in 2.688 HRD-in -84.22, -46.74 70.42, -1.61 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.47, 160.07 APE9-dihe-na 104.92, 173.58 APE8-dihe-in -75.13, 134.82 APE8-rot-in 294.67 APE67-dihe-in -64.87, -22.2 -48.45, -44.36 APE12-dist-in 7.788 APE11-dist-in 11.149 APE10-dist-in 5.605 APE9-dist-in 4.253 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K3 AGC_PRKX_HUMAN AGC 5.6e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus DFGAsp-rot-in -137.29, -177.31 60.22, 109.9 175.76, 18.16 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus DFGAsp-rot-in -137.56, -177.44 62.15, 108.48 175.21, 17.4 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN AF-Q13464-K1A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 6.006 13.066 BLAminus DFGAsp-rot-in -137.66, -178.75 47.45, 69.34 200.5, 17.15 -81.8, 16.56 305.27, 105.28 -65.56, -12.08 in-in in 8.552 Saltbr-in 2.624 HRD-in -74.85, -46.42 64.04, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.58, 160.73 APE9-dihe-na 98.63, 175.06 APE8-dihe-in -68.34, 133.89 APE8-rot-in 288.19 APE67-dihe-in -75.11, -22.05 -52.44, -39.16 APE12-dist-in 10.159 APE11-dist-in 11.26 APE10-dist-in 5.393 APE9-dist-in 3.726 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K1 AGC_ROCK1_HUMAN AGC 9.5e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN AF-Q13464-K3A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 5.851 13.271 BLAminus DFGAsp-rot-in -137.07, 179.96 52.49, 70.51 204.01, 13.06 -80.48, 13.64 307.69, 107.27 -65.8, -8.31 in-in in 8.833 Saltbr-in 2.683 HRD-in -84.07, -47.73 66.69, 2.67 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.35, 143.29 APE9-dihe-na 121.73, 178.17 APE8-dihe-in -80.88, 131.47 APE8-rot-in 300.07 APE67-dihe-in -72.64, -15.78 -48.59, -46.75 APE12-dist-in 10.802 APE11-dist-in 11.642 APE10-dist-in 5.871 APE9-dist-in 3.256 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K3 AGC_ROCK1_HUMAN AGC 9.5e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PA Q13464 6 405 1354.0 3J7:501 Type1 Active DFGin 6.259 12.978 BLAminus DFGAsp-rot-in -131.32, -179.69 55.02, 77.47 198.76, 11.12 -91.49, 17.42 302.12, 101.71 -69.96, -11.88 in-in in 8.182 Saltbr-in 2.566 HRD-in -62.73, -47.54 67.38, -1.52 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.79, 138.22 APE9-dihe-na 110.79, -174.17 APE8-dihe-in -93.29, 129.06 APE8-rot-in 302.8 APE67-dihe-in -74.33, -31.52 -36.7, -38.86 APE12-dist-in 10.731 APE11-dist-in 11.462 APE10-dist-in 5.952 APE9-dist-in 3.674 None None None XRAY 2.8 0.208 0.246 A 411 388 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PB Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.154 13.435 BLAminus DFGAsp-rot-in -133.96, 174.8 56.5, 83.88 178.54, 23.36 -98.36, 33.02 302.17, 98.2 -70.04, -15.43 in-in in 8.214 Saltbr-in 2.726 HRD-in -62.94, -46.77 66.68, -0.73 in-in-in SNCiii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.83, 139.14 APE9-dihe-na 109.13, -172.67 APE8-dihe-in -92.68, 127.41 APE8-rot-in 302.74 APE67-dihe-in -74.45, -31.78 -35.08, -39.48 APE12-dist-in 10.707 APE11-dist-in 11.408 APE10-dist-in 5.883 APE9-dist-in 3.703 None None None XRAY 2.8 0.208 0.246 B 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PC Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.282 13.256 BLAminus DFGAsp-rot-in -124.31, 179.51 53.21, 87.62 191.44, 20.02 -105.48, 23.02 305.5, 95.5 -67.24, -3.72 in-in in 8.257 Saltbr-in 2.797 HRD-in -62.84, -46.85 67.56, -2.48 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.95, 139.35 APE9-dihe-na 109.16, -174.28 APE8-dihe-in -91.11, 127.59 APE8-rot-in 304.22 APE67-dihe-in -73.68, -32.3 -37.14, -39.74 APE12-dist-in 10.725 APE11-dist-in 11.541 APE10-dist-in 6.024 APE9-dist-in 3.675 None None None XRAY 2.8 0.208 0.246 C 411 383 7 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PD Q13464 6 403 1354.0 3J7:501 Type1 Active DFGin 6.352 13.321 BLAminus DFGAsp-rot-in -140.19, -177.5 56.39, 77.39 190.6, 2.96 -95.5, 16.8 300.98, 99.72 -61.76, -14.51 in-in in 8.291 Saltbr-in 2.836 HRD-in -63.87, -49.18 67.62, 4.17 in-in-in SNCiii in-in ActLoopNT-in 3.098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.12, 138.83 APE9-dihe-na 110.39, -175.06 APE8-dihe-in -91.75, 128.12 APE8-rot-in 303.98 APE67-dihe-in -75.08, -31.43 -35.22, -39.46 APE12-dist-in 10.68 APE11-dist-in 11.483 APE10-dist-in 5.932 APE9-dist-in 3.702 None None None XRAY 2.8 0.208 0.246 D 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETKA Q13464 6 405 1354.0 HFS:60416 Type1 Active DFGin 6.059 14.097 BLAminus DFGAsp-rot-in -116.57, 151.42 65.52, 106.25 193.08, -22.07 -118.99, 38.28 303.23, 95.7 -62.53, -30.1 in-in in 9.024 Saltbr-in 3.087 HRD-in -67.16, -45.15 69.82, -9.8 in-in-in SNCiii in-in ActLoopNT-in 3.224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 135.93 APE9-dihe-na 138.1, -153.58 APE8-dihe-in -121.49, 133.91 APE8-rot-in 318.16 APE67-dihe-in -78.08, -32.49 -44.0, -39.32 APE12-dist-in 11.84 APE11-dist-in 11.546 APE10-dist-in 5.856 APE9-dist-in 3.737 None None None XRAY 2.96 0.278 0.298 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etk AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETRA Q13464 6 405 1354.0 Y27:60416 Type1 Active DFGin 6.023 14.033 BLAminus DFGAsp-rot-in -115.35, 151.29 66.22, 120.62 185.79, 11.71 -135.54, 23.8 302.55, 92.69 -59.35, -26.34 in-in in 8.786 Saltbr-in 2.733 HRD-in -66.03, -45.85 73.19, -11.33 in-in-in SNCiii in-in ActLoopNT-in 3.095 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 135.12 APE9-dihe-na 138.18, -155.48 APE8-dihe-in -122.76, 133.42 APE8-rot-in 310.03 APE67-dihe-in -71.74, -29.22 -38.34, -50.83 APE12-dist-in 11.748 APE11-dist-in 11.548 APE10-dist-in 5.877 APE9-dist-in 3.701 None None None XRAY 2.6 0.252 0.266 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etr AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3D9VA Q13464 6 405 1354.0 H52:60416 Type1 Active DFGin 6.202 14.259 BLAminus DFGAsp-rot-in -97.17, 154.71 64.91, 125.89 173.22, 64.61 -137.95, 39.08 298.06, 99.68 -71.65, -6.65 in-in in 9.177 Saltbr-in 3.154 HRD-in -71.72, -45.61 70.74, -5.17 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.18, 131.07 APE9-dihe-na 140.68, -156.12 APE8-dihe-in -114.86, 135.68 APE8-rot-in 311.45 APE67-dihe-in -80.47, -37.33 -48.71, -38.59 APE12-dist-in 11.746 APE11-dist-in 11.776 APE10-dist-in 6.137 APE9-dist-in 3.756 None None None XRAY 3.3 0.262 0.28 A 415 400 0 0 0 0 [[76, 338]] 1.0 3d9v AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVCA Q13464 6 405 1354.0 4KH:60501 Type1 Active DFGin 5.87 13.114 BLAminus DFGAsp-rot-in -131.73, 179.43 49.79, 78.91 196.76, -3.88 -95.58, 35.98 309.76, 96.36 -52.74, -39.15 in-in in 8.425 Saltbr-in 3.027 HRD-in -62.91, -47.72 78.09, -4.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 137.86 APE9-dihe-na 126.1, -158.78 APE8-dihe-in -106.17, 145.81 APE8-rot-in 290.0 APE67-dihe-in -72.07, -14.66 -55.89, -48.56 APE12-dist-in 11.644 APE11-dist-in 11.414 APE10-dist-in 5.915 APE9-dist-in 3.809 None None None XRAY 3.2 0.193 0.221 A 415 388 5 0 0 0 [[76, 338]] 1.0 4yvc AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVEA Q13464 6 405 1354.0 4KK:60501 Type1 Active DFGin 5.621 12.807 BLAminus DFGAsp-rot-in -135.63, 174.2 57.57, 62.47 168.6, 32.55 -84.06, 54.44 321.53, 81.4 -64.54, -38.78 in-in in 8.392 Saltbr-in 2.839 HRD-in -66.81, -33.75 61.05, -11.49 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 139.44 APE9-dihe-na 133.32, -156.65 APE8-dihe-in -109.47, 141.28 APE8-rot-in 300.76 APE67-dihe-in -87.71, -40.47 -52.3, -33.35 APE12-dist-in 11.916 APE11-dist-in 11.54 APE10-dist-in 6.006 APE9-dist-in 3.84 None None None XRAY 3.4 0.219 0.244 A 415 390 4 0 0 0 [[76, 338]] 1.0 4yve AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5BMLA Q13464 6 405 1354.0 4TW:60501 Type1 Active DFGin 6.166 13.115 BLAminus DFGAsp-rot-in -136.45, -178.03 52.19, 80.38 188.51, 26.99 -99.05, 18.0 302.5, 105.79 -59.89, -6.36 in-in in 8.173 Saltbr-in 2.761 HRD-in -66.74, -49.49 70.73, -5.79 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.01, 144.84 APE9-dihe-na 123.64, -151.58 APE8-dihe-in -116.7, 138.56 APE8-rot-in 292.02 APE67-dihe-in -71.41, -43.61 -45.01, -45.51 APE12-dist-in 12.171 APE11-dist-in 11.52 APE10-dist-in 6.047 APE9-dist-in 3.748 None None None XRAY 2.95 0.207 0.235 A 415 393 2 0 0 0 [[76, 338]] 1.0 5bml AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSA Q13464 6 405 1354.0 6U1:60501 Type1 Active DFGin 6.186 13.352 BLAminus DFGAsp-rot-in -142.64, 177.27 59.6, 62.04 199.21, -31.59 -81.65, 21.26 304.3, 101.28 -54.79, -41.15 in-in in 8.259 Saltbr-in 2.754 HRD-in -54.42, -38.35 63.96, -11.55 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.2, 147.03 APE9-dihe-na 120.6, -151.04 APE8-dihe-in -115.4, 140.07 APE8-rot-in 299.71 APE67-dihe-in -59.58, -43.85 -44.15, -59.93 APE12-dist-in 11.887 APE11-dist-in 11.441 APE10-dist-in 5.829 APE9-dist-in 3.748 None None None XRAY 3.3 0.215 0.254 A 415 395 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTA Q13464 6 405 1354.0 6U2:60501 Type1 Active DFGin 6.335 13.585 BLAminus DFGAsp-rot-in -128.59, -176.48 50.52, 79.42 196.8, 0.41 -95.97, 17.69 299.29, 99.89 -62.82, -14.55 in-in in 8.893 Saltbr-in 2.772 HRD-in -67.63, -48.61 71.19, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, 142.19 APE9-dihe-na 128.21, -142.04 APE8-dihe-in -128.93, 139.4 APE8-rot-in 303.92 APE67-dihe-in -73.59, -33.97 -48.22, -44.35 APE12-dist-in 11.474 APE11-dist-in 11.675 APE10-dist-in 6.173 APE9-dist-in 3.606 None None None XRAY 2.8 0.223 0.237 A 415 389 4 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5UZJA Q13464 6 405 1354.0 8UV:60501 Type1 Active DFGin 6.17 13.101 BLAminus DFGAsp-rot-in -139.82, 174.8 51.53, 74.94 183.89, 17.98 -94.18, 44.21 303.79, 97.11 -58.95, -59.6 in-in in 8.64 Saltbr-in 2.794 HRD-in -71.22, -41.37 70.75, -24.52 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.33, 135.82 APE9-dihe-na 134.09, -159.86 APE8-dihe-in -104.52, 140.59 APE8-rot-in 298.4 APE67-dihe-in -92.6, -25.3 -52.4, -27.33 APE12-dist-in 11.906 APE11-dist-in 11.503 APE10-dist-in 5.992 APE9-dist-in 4.031 None None None XRAY 3.3 0.202 0.241 A 415 387 8 0 0 0 [[76, 338]] 1.0 5uzj AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUA Q13464 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus DFGAsp-rot-in -144.77, -177.33 55.22, 80.15 194.27, 8.27 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEA Q13464 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus DFGAsp-rot-in -135.0, 175.35 53.04, 84.77 186.88, 58.35 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEC Q13464 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus DFGAsp-rot-in -141.6, 173.01 60.67, 84.57 201.57, -2.47 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNED Q13464 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus DFGAsp-rot-in -136.38, 179.68 48.06, 76.76 196.48, 0.38 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN AF-O75116-K1A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.869 12.915 BLAminus DFGAsp-rot-in -136.99, 177.96 53.48, 73.71 201.61, 26.61 -86.19, 14.62 307.2, 104.5 -65.86, -9.9 in-in in 8.731 Saltbr-in 2.651 HRD-in -85.23, -49.89 67.76, 1.46 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 135.21 APE9-dihe-na 135.69, 171.46 APE8-dihe-in -70.75, 130.03 APE8-rot-in 300.74 APE67-dihe-in -77.08, -19.45 -51.29, -40.8 APE12-dist-in 10.485 APE11-dist-in 11.568 APE10-dist-in 5.755 APE9-dist-in 3.634 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[92, 354]] 1.0 AF-O75116-K1 AGC_ROCK2_HUMAN AGC 7.1e-94 319.7 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN AF-O75116-K3A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.82 13.449 BLAminus DFGAsp-rot-in -136.65, 179.19 54.41, 68.61 204.25, 7.76 -80.36, 13.1 307.71, 103.33 -65.49, -10.01 in-in in 8.674 Saltbr-in 2.629 HRD-in -85.92, -46.0 66.47, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 142.1 APE9-dihe-na 129.39, 171.44 APE8-dihe-in -69.98, 129.02 APE8-rot-in 286.32 APE67-dihe-in -70.68, -17.36 -43.25, -51.09 APE12-dist-in 10.635 APE11-dist-in 11.941 APE10-dist-in 6.01 APE9-dist-in 3.263 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[92, 354]] 1.0 AF-O75116-K3 AGC_ROCK2_HUMAN AGC 7.1e-94 319.7 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8XA O75116 32 417 1388.0 YDW:501 Type1 Active DFGin 6.358 13.618 BLAminus DFGAsp-rot-in -145.81, -178.89 53.82, 76.54 193.51, 1.98 -97.16, 31.49 303.8, 87.87 -66.69, -28.82 in-in in 8.957 Saltbr-in 2.665 HRD-in -74.39, -58.56 77.08, -1.86 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.16, 162.89 APE9-dihe-na 114.79, -140.41 APE8-dihe-in -127.19, 138.75 APE8-rot-in 307.63 APE67-dihe-in -63.05, -28.14 -61.81, -39.49 APE12-dist-in 10.396 APE11-dist-in 11.705 APE10-dist-in 5.857 APE9-dist-in 3.8 None None None XRAY 2.6 0.201 0.253 A 391 380 0 0 0 0 [[92, 354]] 1.0 8x8x AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6A O75116 27 415 1388.0 J0P:501 Type1 Active DFGin 6.479 13.361 BLAminus DFGAsp-rot-in -145.19, 179.01 60.98, 63.29 195.62, 15.02 -87.07, 23.13 303.43, 107.85 -60.41, -48.86 in-in in 8.532 Saltbr-in 2.744 HRD-in -56.44, -54.27 71.45, -18.59 in-in-in SNCiii in-in ActLoopNT-in 3.439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.8, 126.02 APE9-dihe-na 153.03, -163.23 APE8-dihe-in -114.06, 130.07 APE8-rot-in 328.57 APE67-dihe-in -55.65, -29.13 -25.97, -72.15 APE12-dist-in 10.492 APE11-dist-in 11.382 APE10-dist-in 5.553 APE9-dist-in 3.96 None None None XRAY 2.86 0.206 0.247 A 415 378 4 0 0 0 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.7e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K1A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.621 14.355 BLAminus DFGAsp-rot-in -124.04, -166.26 40.15, 63.05 204.37, 27.6 -75.14, 13.01 287.46, 77.73 -62.04, -17.57 in-in in 8.996 Saltbr-in 2.655 HRD-in -82.17, -49.64 65.88, 6.04 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.23, 164.1 APE9-dihe-na 113.31, 168.76 APE8-dihe-in -68.46, 130.82 APE8-rot-in 292.77 APE67-dihe-in -60.62, -26.43 -61.01, -40.77 APE12-dist-in 8.416 APE11-dist-in 11.406 APE10-dist-in 5.696 APE9-dist-in 3.493 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K1 AGC_RPS6KA1-1_HUMAN AGC 9.2e-96 325.9 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K3A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.446 14.352 BLAminus DFGAsp-rot-in -131.09, -177.74 50.28, 63.61 203.37, 13.88 -71.56, 10.34 294.57, 83.15 -62.78, -13.6 in-in in 8.88 Saltbr-in 2.663 HRD-in -82.73, -46.46 67.14, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.19, 164.66 APE9-dihe-na 112.66, 172.32 APE8-dihe-in -74.19, 134.18 APE8-rot-in 293.08 APE67-dihe-in -61.38, -26.34 -64.42, -40.72 APE12-dist-in 8.366 APE11-dist-in 11.432 APE10-dist-in 5.676 APE9-dist-in 3.387 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K3 AGC_RPS6KA1-1_HUMAN AGC 9.2e-96 325.9 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA2-1 KS6A2_HUMAN AF-Q15349-K1A Q15349 51 326 733.0 No_ligand No_ligand Active DFGin 6.56 14.298 BLAminus DFGAsp-rot-in -128.83, -162.98 39.17, 62.6 202.27, 27.67 -73.7, 13.33 288.23, 79.39 -63.05, -17.58 in-in in 8.746 Saltbr-in 2.618 HRD-in -82.39, -49.82 64.45, 9.53 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.56, 163.19 APE9-dihe-na 114.31, 169.62 APE8-dihe-in -69.73, 130.78 APE8-rot-in 293.85 APE67-dihe-in -60.4, -27.19 -59.3, -42.05 APE12-dist-in 8.399 APE11-dist-in 11.444 APE10-dist-in 5.699 APE9-dist-in 3.539 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K1 AGC_RPS6KA2-1_HUMAN AGC 6.3e-97 329.7 1 260 260 201 202 203 205 207 91 109 113 181 183 182 184 241 229 224 223 222 221 220 219 218 139 Ribosomal protein S6 kinase alpha-2
AGC RPS6KA2-1 KS6A2_HUMAN AF-Q15349-K3A Q15349 51 326 733.0 No_ligand No_ligand Active DFGin 6.434 14.159 BLAminus DFGAsp-rot-in -128.23, -175.81 52.4, 64.67 204.58, 16.81 -72.62, 10.99 294.75, 82.08 -64.43, -12.72 in-in in 8.626 Saltbr-in 2.643 HRD-in -85.46, -48.02 66.82, 11.67 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.59, 164.28 APE9-dihe-na 111.5, 172.79 APE8-dihe-in -74.02, 136.08 APE8-rot-in 294.1 APE67-dihe-in -63.58, -25.11 -70.41, -35.48 APE12-dist-in 8.374 APE11-dist-in 11.421 APE10-dist-in 5.655 APE9-dist-in 3.388 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K3 AGC_RPS6KA2-1_HUMAN AGC 6.3e-97 329.7 1 260 260 201 202 203 205 207 91 109 113 181 183 182 184 241 229 224 223 222 221 220 219 218 139 Ribosomal protein S6 kinase alpha-2
AGC RPS6KA3-1 KS6A3_HUMAN AF-P51812-K1A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.764 14.365 BLAminus DFGAsp-rot-in -128.08, -168.93 44.14, 64.08 203.55, 24.75 -76.47, 13.22 289.9, 79.47 -63.08, -17.42 in-in in 8.864 Saltbr-in 2.673 HRD-in -82.22, -48.58 63.74, 10.13 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.28, 165.34 APE9-dihe-na 113.22, 171.27 APE8-dihe-in -72.62, 129.88 APE8-rot-in 293.52 APE67-dihe-in -60.98, -26.44 -58.38, -41.01 APE12-dist-in 8.476 APE11-dist-in 11.414 APE10-dist-in 5.681 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K1 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN AF-P51812-K3A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.499 14.162 BLAminus DFGAsp-rot-in -131.58, -177.03 51.85, 64.94 202.82, 13.21 -73.26, 9.93 296.53, 86.04 -63.15, -12.88 in-in in 8.786 Saltbr-in 2.627 HRD-in -83.1, -49.32 68.04, 9.8 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.96, 166.11 APE9-dihe-na 108.7, 179.24 APE8-dihe-in -85.77, 132.92 APE8-rot-in 303.81 APE67-dihe-in -62.2, -27.77 -65.91, -38.69 APE12-dist-in 8.389 APE11-dist-in 11.43 APE10-dist-in 5.673 APE9-dist-in 3.362 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K3 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA4-1 KS6A4_HUMAN AF-O75676-K1A O75676 25 309 772.0 No_ligand No_ligand Active DFGin 6.598 13.71 BLAminus DFGAsp-rot-in -124.98, -168.39 42.55, 70.55 203.29, 24.06 -80.59, 14.7 297.97, 83.91 -61.19, -20.29 in-in in 8.77 Saltbr-in 2.604 HRD-in -82.76, -47.29 63.76, 4.18 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.03, 161.17 APE9-dihe-na 111.84, 169.32 APE8-dihe-in -72.29, 131.49 APE8-rot-in 292.11 APE67-dihe-in -60.98, -29.84 -59.69, -36.55 APE12-dist-in 8.541 APE11-dist-in 11.517 APE10-dist-in 5.761 APE9-dist-in 3.594 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K1 AGC_RPS6KA4-1_HUMAN AGC 5.9e-92 313.4 1 260 260 178 179 180 182 184 65 85 89 158 160 159 161 220 207 202 201 200 199 198 197 196 116 Ribosomal protein S6 kinase alpha-4
AGC RPS6KA4-1 KS6A4_HUMAN AF-O75676-K3A O75676 25 309 772.0 No_ligand No_ligand Active DFGin 5.878 13.345 BLAminus DFGAsp-rot-in -137.86, 174.13 57.75, 77.02 204.17, -4.77 -80.17, 14.68 304.16, 99.37 -63.32, -16.55 in-in in 8.703 Saltbr-in 2.623 HRD-in -79.41, -52.95 68.65, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.69, 162.48 APE9-dihe-na 107.74, -177.94 APE8-dihe-in -90.07, 132.25 APE8-rot-in 304.86 APE67-dihe-in -59.91, -31.29 -62.41, -36.29 APE12-dist-in 8.34 APE11-dist-in 11.525 APE10-dist-in 5.775 APE9-dist-in 3.898 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K3 AGC_RPS6KA4-1_HUMAN AGC 5.9e-92 313.4 1 260 260 178 179 180 182 184 65 85 89 158 160 159 161 220 207 202 201 200 199 198 197 196 116 Ribosomal protein S6 kinase alpha-4
AGC RPS6KA5-1 KS6A5_HUMAN AF-O75582-K1A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.78 13.79 BLAminus DFGAsp-rot-in -122.36, -163.26 38.53, 66.9 205.82, 19.55 -78.09, 17.93 295.37, 82.19 -64.85, -18.18 in-in in 8.796 Saltbr-in 2.625 HRD-in -82.76, -49.06 64.23, 11.02 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 163.8 APE9-dihe-na 113.59, 179.22 APE8-dihe-in -90.62, 126.59 APE8-rot-in 304.99 APE67-dihe-in -61.69, -29.36 -58.71, -34.47 APE12-dist-in 8.406 APE11-dist-in 11.56 APE10-dist-in 5.806 APE9-dist-in 3.557 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K1 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA5-1 KS6A5_HUMAN AF-O75582-K3A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.186 13.358 BLAminus DFGAsp-rot-in -132.07, -177.35 48.31, 79.01 206.54, -5.16 -81.08, 17.52 302.26, 93.07 -63.99, -14.82 in-in in 8.702 Saltbr-in 2.577 HRD-in -86.05, -53.15 68.0, 7.54 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.1, 160.71 APE9-dihe-na 110.46, -176.37 APE8-dihe-in -88.86, 131.0 APE8-rot-in 291.71 APE67-dihe-in -59.57, -30.36 -60.19, -36.11 APE12-dist-in 8.116 APE11-dist-in 11.406 APE10-dist-in 5.697 APE9-dist-in 3.59 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K3 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA6-1 KS6A6_HUMAN AF-Q9UK32-K1A Q9UK32 65 338 745.0 No_ligand No_ligand Active DFGin 6.717 14.38 BLAminus DFGAsp-rot-in -122.74, -167.91 42.21, 63.67 203.33, 27.47 -74.28, 13.2 286.97, 79.25 -62.83, -17.84 in-in in 8.957 Saltbr-in 2.617 HRD-in -80.3, -49.99 66.24, 7.44 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.5, 163.94 APE9-dihe-na 113.91, 169.75 APE8-dihe-in -69.91, 129.74 APE8-rot-in 294.78 APE67-dihe-in -61.58, -27.56 -58.44, -40.04 APE12-dist-in 8.319 APE11-dist-in 11.322 APE10-dist-in 5.613 APE9-dist-in 3.564 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K1 AGC_RPS6KA6-1_HUMAN AGC 7.6e-98 332.7 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN AF-Q9UK32-K3A Q9UK32 65 338 745.0 No_ligand No_ligand Active DFGin 6.501 14.102 BLAminus DFGAsp-rot-in -132.27, -175.76 52.2, 64.77 205.05, 14.17 -72.92, 11.15 296.44, 84.22 -64.03, -14.25 in-in in 8.777 Saltbr-in 2.623 HRD-in -81.65, -46.67 67.29, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.4, 164.19 APE9-dihe-na 112.49, 174.41 APE8-dihe-in -75.23, 135.24 APE8-rot-in 295.17 APE67-dihe-in -61.93, -26.66 -66.02, -39.52 APE12-dist-in 8.423 APE11-dist-in 11.441 APE10-dist-in 5.694 APE9-dist-in 3.368 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K3 AGC_RPS6KA6-1_HUMAN AGC 7.6e-98 332.7 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KB1 KS6B1_HUMAN AF-P23443-K1A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.85 14.148 BLAminus DFGAsp-rot-in -124.31, -166.39 38.73, 66.43 205.1, 24.77 -77.66, 13.72 288.38, 76.88 -63.66, -21.1 in-in in 8.764 Saltbr-in 2.612 HRD-in -85.2, -47.45 63.14, 5.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.51, 166.53 APE9-dihe-na 111.13, -177.37 APE8-dihe-in -97.94, 129.35 APE8-rot-in 304.6 APE67-dihe-in -59.86, -23.05 -60.69, -41.68 APE12-dist-in 8.424 APE11-dist-in 11.405 APE10-dist-in 5.675 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K1 AGC_RPS6KB1_HUMAN AGC 2.6e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN AF-P23443-K3A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.499 13.931 BLAminus DFGAsp-rot-in -128.06, -173.88 44.57, 66.94 206.78, 17.91 -75.34, 10.89 293.5, 80.29 -60.23, -27.79 in-in in 8.905 Saltbr-in 2.613 HRD-in -82.97, -50.48 68.32, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 169.69 APE9-dihe-na 107.2, 177.16 APE8-dihe-in -89.35, 135.4 APE8-rot-in 302.12 APE67-dihe-in -65.67, -26.41 -68.11, -34.82 APE12-dist-in 8.273 APE11-dist-in 11.346 APE10-dist-in 5.632 APE9-dist-in 3.355 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K3 AGC_RPS6KB1_HUMAN AGC 2.6e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB2 KS6B2_HUMAN AF-Q9UBS0-K1A Q9UBS0 59 336 482.0 No_ligand No_ligand Active DFGin 6.767 14.153 BLAminus DFGAsp-rot-in -122.6, -163.21 32.52, 70.94 205.93, 17.73 -79.17, 14.37 282.5, 73.29 -66.4, -18.33 in-in in 9.058 Saltbr-in 2.658 HRD-in -85.1, -48.99 62.91, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.67, 166.83 APE9-dihe-na 112.36, -178.82 APE8-dihe-in -94.75, 128.18 APE8-rot-in 304.35 APE67-dihe-in -60.99, -23.51 -55.81, -43.33 APE12-dist-in 8.296 APE11-dist-in 11.418 APE10-dist-in 5.72 APE9-dist-in 3.404 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[67, 328]] 1.0 AF-Q9UBS0-K1 AGC_RPS6KB2_HUMAN AGC 2.1e-95 324.7 1 260 260 211 212 213 215 217 99 119 123 191 193 192 194 251 239 234 233 232 231 230 229 228 149 Ribosomal protein S6 kinase beta-2
AGC RPS6KB2 KS6B2_HUMAN AF-Q9UBS0-K3A Q9UBS0 59 336 482.0 No_ligand No_ligand Active DFGin 6.562 13.94 BLAminus DFGAsp-rot-in -128.82, -176.09 45.46, 64.71 207.48, 19.07 -72.89, 13.46 297.09, 86.74 -63.72, -26.05 in-in in 8.846 Saltbr-in 2.62 HRD-in -82.85, -49.48 67.58, 9.22 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.3, 167.26 APE9-dihe-na 111.46, 179.11 APE8-dihe-in -88.78, 132.69 APE8-rot-in 290.07 APE67-dihe-in -60.12, -23.72 -65.21, -38.72 APE12-dist-in 8.179 APE11-dist-in 11.341 APE10-dist-in 5.623 APE9-dist-in 3.377 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[67, 328]] 1.0 AF-Q9UBS0-K3 AGC_RPS6KB2_HUMAN AGC 2.1e-95 324.7 1 260 260 211 212 213 215 217 99 119 123 191 193 192 194 251 239 234 233 232 231 230 229 228 149 Ribosomal protein S6 kinase beta-2
AGC RSKR KS6R_HUMAN AF-Q96LW2-K1A Q96LW2 99 367 410.0 No_ligand No_ligand Active DFGin 6.001 14.413 BLAminus DFGAsp-rot-in -128.15, 175.11 63.05, 70.74 203.01, 9.58 -77.02, 14.42 296.82, 82.95 -59.41, -30.24 in-in in 9.187 Saltbr-in 2.761 HRD-in -72.59, -46.98 65.7, 9.25 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.27, 158.07 APE9-dihe-na 116.39, -173.48 APE8-dihe-in -88.12, 124.34 APE8-rot-in 302.8 APE67-dihe-in -69.33, -19.53 -47.96, -47.56 APE12-dist-in 9.264 APE11-dist-in 11.918 APE10-dist-in 6.183 APE9-dist-in 3.33 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[107, 359]] 1.0 AF-Q96LW2-K1 AGC_RSKR_HUMAN AGC 2.7e-69 239.1 2 260 259 246 247 248 250 252 136 155 159 226 228 227 229 285 273 268 267 266 265 264 263 262 185 Ribosomal protein S6 kinase-related protein
AGC RSKR KS6R_HUMAN AF-Q96LW2-K3A Q96LW2 99 367 410.0 No_ligand No_ligand Active DFGin 6.015 14.381 BLAminus DFGAsp-rot-in -130.08, -176.68 56.94, 61.03 206.75, 13.39 -66.7, 14.64 294.77, 81.62 -63.54, -22.02 in-in in 9.311 Saltbr-in 2.759 HRD-in -79.07, -48.39 69.1, 3.8 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.04, 159.89 APE9-dihe-na 119.8, -171.41 APE8-dihe-in -96.32, 125.52 APE8-rot-in 302.07 APE67-dihe-in -64.39, -22.74 -47.43, -45.47 APE12-dist-in 8.888 APE11-dist-in 11.657 APE10-dist-in 5.981 APE9-dist-in 3.373 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[107, 359]] 1.0 AF-Q96LW2-K3 AGC_RSKR_HUMAN AGC 2.7e-69 239.1 2 260 259 246 247 248 250 252 136 155 159 226 228 227 229 285 273 268 267 266 265 264 263 262 185 Ribosomal protein S6 kinase-related protein
AGC SGK1 SGK1_HUMAN AF-O00141-K1A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.581 13.124 BLAminus DFGAsp-rot-in -124.65, -166.79 42.56, 64.43 203.37, 17.06 -73.44, 18.78 305.22, 97.86 -59.66, -29.15 in-in in 8.643 Saltbr-in 2.619 HRD-in -74.89, -49.13 66.3, -0.59 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.35, 160.2 APE9-dihe-na 121.68, 167.97 APE8-dihe-in -78.59, 129.41 APE8-rot-in 299.24 APE67-dihe-in -64.62, -22.89 -47.15, -41.83 APE12-dist-in 8.396 APE11-dist-in 11.598 APE10-dist-in 5.867 APE9-dist-in 3.664 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-O00141-K1 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN AF-O00141-K3A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.302 13.205 BLAminus DFGAsp-rot-in -132.91, -176.65 51.85, 63.47 207.46, 14.71 -69.17, 14.1 303.31, 90.06 -64.44, -24.17 in-in in 8.874 Saltbr-in 2.646 HRD-in -80.08, -49.64 66.81, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.31, 163.89 APE9-dihe-na 116.3, 167.63 APE8-dihe-in -77.55, 132.12 APE8-rot-in 281.34 APE67-dihe-in -64.39, -24.37 -47.8, -41.95 APE12-dist-in 8.43 APE11-dist-in 11.586 APE10-dist-in 5.913 APE9-dist-in 3.428 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-O00141-K3 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK2 SGK2_HUMAN AF-Q9HBY8-K1A Q9HBY8 27 300 367.0 No_ligand No_ligand Active DFGin 6.757 13.183 BLAminus DFGAsp-rot-in -126.19, -164.1 40.86, 62.15 206.42, 19.58 -71.83, 20.65 305.11, 102.31 -61.65, -30.88 in-in in 8.474 Saltbr-in 2.632 HRD-in -81.71, -47.54 64.15, 1.17 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.38, 158.67 APE9-dihe-na 125.17, 168.37 APE8-dihe-in -80.06, 129.55 APE8-rot-in 299.85 APE67-dihe-in -63.96, -21.91 -47.78, -42.81 APE12-dist-in 8.307 APE11-dist-in 11.589 APE10-dist-in 5.847 APE9-dist-in 3.631 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[35, 292]] 1.0 AF-Q9HBY8-K1 AGC_SGK2_HUMAN AGC 5.4e-97 329.9 1 260 260 176 177 178 180 182 64 83 87 156 158 157 159 216 204 199 198 197 196 195 194 193 114 Serine/threonine-protein kinase Sgk2
AGC SGK2 SGK2_HUMAN AF-Q9HBY8-K3A Q9HBY8 27 300 367.0 No_ligand No_ligand Active DFGin 6.008 12.725 BLAminus DFGAsp-rot-in -136.14, -177.62 55.87, 64.97 206.14, 11.23 -72.87, 17.08 309.8, 105.75 -66.38, -25.27 in-in in 8.572 Saltbr-in 2.609 HRD-in -79.56, -49.81 67.65, 8.61 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.72, 160.21 APE9-dihe-na 128.5, 178.27 APE8-dihe-in -92.21, 130.85 APE8-rot-in 293.37 APE67-dihe-in -64.53, -22.85 -47.18, -44.94 APE12-dist-in 8.561 APE11-dist-in 11.589 APE10-dist-in 5.894 APE9-dist-in 3.38 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[35, 292]] 1.0 AF-Q9HBY8-K3 AGC_SGK2_HUMAN AGC 5.4e-97 329.9 1 260 260 176 177 178 180 182 64 83 87 156 158 157 159 216 204 199 198 197 196 195 194 193 114 Serine/threonine-protein kinase Sgk2
AGC SGK3 SGK3_HUMAN AF-Q96BR1-K1A Q96BR1 154 427 496.0 No_ligand No_ligand Active DFGin 6.554 13.233 BLAminus DFGAsp-rot-in -124.26, -164.17 39.89, 62.61 205.91, 18.14 -70.98, 20.78 304.51, 99.52 -61.78, -29.79 in-in in 8.749 Saltbr-in 2.617 HRD-in -76.68, -49.81 63.69, 3.76 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.42, 161.15 APE9-dihe-na 124.64, 167.92 APE8-dihe-in -81.48, 130.81 APE8-rot-in 298.9 APE67-dihe-in -65.23, -22.01 -49.05, -42.13 APE12-dist-in 8.372 APE11-dist-in 11.657 APE10-dist-in 5.911 APE9-dist-in 3.584 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[162, 419]] 1.0 AF-Q96BR1-K1 AGC_SGK3_HUMAN AGC 1.6e-96 328.4 1 260 260 303 304 305 307 309 191 210 214 283 285 284 286 343 331 326 325 324 323 322 321 320 241 Serine/threonine-protein kinase Sgk3
AGC SGK3 SGK3_HUMAN AF-Q96BR1-K3A Q96BR1 154 427 496.0 No_ligand No_ligand Active DFGin 6.057 12.929 BLAminus DFGAsp-rot-in -127.24, -166.5 45.66, 62.91 206.92, 17.28 -70.24, 20.11 307.22, 99.55 -62.39, -28.8 in-in in 8.846 Saltbr-in 2.67 HRD-in -78.27, -50.26 68.22, 4.19 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.59, 166.93 APE9-dihe-na 122.01, -178.74 APE8-dihe-in -96.73, 130.87 APE8-rot-in 294.73 APE67-dihe-in -66.48, -22.51 -48.92, -42.34 APE12-dist-in 8.575 APE11-dist-in 11.523 APE10-dist-in 5.886 APE9-dist-in 3.513 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[162, 419]] 1.0 AF-Q96BR1-K3 AGC_SGK3_HUMAN AGC 1.6e-96 328.4 1 260 260 303 304 305 307 309 191 210 214 283 285 284 286 343 331 326 325 324 323 322 321 320 241 Serine/threonine-protein kinase Sgk3
AGC STK32A ST32A_HUMAN AF-Q8WU08-K1A Q8WU08 15 289 396.0 No_ligand No_ligand Active DFGin 6.691 14.98 BLAminus DFGAsp-rot-in -134.52, 176.14 62.68, 72.52 194.49, 9.22 -81.94, 13.61 288.18, 84.89 -57.12, -36.56 in-in in 9.737 Saltbr-in 2.732 HRD-in -76.02, -47.46 67.94, -2.78 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.29, 143.95 APE9-dihe-na 133.56, 174.14 APE8-dihe-in -86.99, 107.05 APE8-rot-in 307.27 APE67-dihe-in -67.4, -14.96 -36.72, -45.57 APE12-dist-in 9.919 APE11-dist-in 11.672 APE10-dist-in 5.831 APE9-dist-in 3.353 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[23, 281]] 1.0 AF-Q8WU08-K1 AGC_STK32A_HUMAN AGC 2.6e-84 288.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN AF-Q8WU08-K3A Q8WU08 15 289 396.0 No_ligand No_ligand Active DFGin 6.205 14.899 BLAminus DFGAsp-rot-in -134.69, 175.4 63.51, 72.19 199.57, 13.11 -77.61, 13.96 291.45, 89.04 -57.55, -31.55 in-in in 9.385 Saltbr-in 2.755 HRD-in -71.4, -43.65 68.44, -0.86 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.44, 147.52 APE9-dihe-na 129.41, -176.11 APE8-dihe-in -96.11, 105.57 APE8-rot-in 302.12 APE67-dihe-in -61.84, -14.72 -39.2, -44.55 APE12-dist-in 9.655 APE11-dist-in 11.314 APE10-dist-in 5.491 APE9-dist-in 3.189 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[23, 281]] 1.0 AF-Q8WU08-K3 AGC_STK32A_HUMAN AGC 2.6e-84 288.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32B ST32B_HUMAN AF-Q9NY57-K1A Q9NY57 15 291 414.0 No_ligand No_ligand Active DFGin 6.389 14.494 BLAminus DFGAsp-rot-in -131.15, 175.38 60.66, 77.05 197.98, 24.58 -86.03, 14.25 289.41, 82.97 -54.59, -32.73 in-in in 9.412 Saltbr-in 2.665 HRD-in -72.16, -47.9 68.07, 0.25 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.39, 143.77 APE9-dihe-na 122.75, 173.75 APE8-dihe-in -83.96, 113.15 APE8-rot-in 305.79 APE67-dihe-in -68.57, -13.85 -36.75, -46.17 APE12-dist-in 8.799 APE11-dist-in 11.28 APE10-dist-in 5.446 APE9-dist-in 3.289 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[23, 283]] 1.0 AF-Q9NY57-K1 AGC_STK32B_HUMAN AGC 6.8e-82 280.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 207 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32B
AGC STK32B ST32B_HUMAN AF-Q9NY57-K3A Q9NY57 15 291 414.0 No_ligand No_ligand Active DFGin 6.106 14.902 BLAminus DFGAsp-rot-in -134.32, 176.3 62.98, 74.94 200.62, 9.45 -81.48, 14.43 292.36, 87.95 -58.47, -30.42 in-in in 9.309 Saltbr-in 2.809 HRD-in -72.82, -43.64 70.33, -0.26 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.35, 141.75 APE9-dihe-na 128.67, -173.61 APE8-dihe-in -100.23, 110.09 APE8-rot-in 305.19 APE67-dihe-in -65.55, -13.75 -38.89, -45.84 APE12-dist-in 9.023 APE11-dist-in 11.276 APE10-dist-in 5.378 APE9-dist-in 3.285 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[23, 283]] 1.0 AF-Q9NY57-K3 AGC_STK32B_HUMAN AGC 6.8e-82 280.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 207 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32B
AGC STK32C ST32C_HUMAN AF-Q86UX6-K3A Q86UX6 85 361 486.0 No_ligand No_ligand Active DFGin 6.618 14.728 BLAminus DFGAsp-rot-in -140.78, 178.78 62.47, 74.47 198.96, 8.69 -81.32, 15.05 293.91, 85.17 -58.16, -28.82 in-in in 9.129 Saltbr-in 2.666 HRD-in -73.3, -43.21 68.03, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 142.63 APE9-dihe-na 125.48, -179.79 APE8-dihe-in -94.87, 111.14 APE8-rot-in 302.22 APE67-dihe-in -64.85, -15.99 -40.84, -43.79 APE12-dist-in 9.122 APE11-dist-in 11.355 APE10-dist-in 5.582 APE9-dist-in 3.184 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[93, 353]] 1.0 AF-Q86UX6-K3 AGC_STK32C_HUMAN AGC 4e-82 281.2 1 258 258 233 234 235 237 239 122 141 145 213 215 214 216 277 260 255 254 253 252 251 250 249 171 Serine/threonine-protein kinase 32C
AGC STK38 STK38_HUMAN AF-Q15208-K1A Q15208 81 390 465.0 No_ligand No_ligand Active DFGin 6.259 13.072 BLAminus DFGAsp-rot-in -134.61, 173.44 54.06, 73.9 200.68, 16.13 -81.72, 14.99 305.51, 100.34 -63.52, -18.16 in-in in 8.716 Saltbr-in 2.595 HRD-in -72.89, -52.36 66.95, 13.5 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.32, 156.98 APE9-dihe-na 128.63, -175.74 APE8-dihe-in -93.85, 123.58 APE8-rot-in 301.4 APE67-dihe-in -70.52, -20.09 -45.54, -41.13 APE12-dist-in 8.669 APE11-dist-in 11.616 APE10-dist-in 5.73 APE9-dist-in 3.329 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[89, 382]] 1.0 AF-Q15208-K1 AGC_STK38_HUMAN AGC 2.2e-98 334.5 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN AF-Q15208-K3A Q15208 81 390 465.0 No_ligand No_ligand Active DFGin 6.274 12.898 BLAminus DFGAsp-rot-in -140.2, -177.63 50.78, 63.8 200.25, 16.32 -70.85, 11.95 306.06, 111.32 -64.39, -16.5 in-in in 8.668 Saltbr-in 2.613 HRD-in -73.09, -52.84 69.33, 0.49 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 152.58 APE9-dihe-na 134.45, 168.77 APE8-dihe-in -78.44, 129.3 APE8-rot-in 298.45 APE67-dihe-in -74.77, -20.02 -52.75, -38.1 APE12-dist-in 8.716 APE11-dist-in 11.62 APE10-dist-in 5.739 APE9-dist-in 3.208 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[89, 382]] 1.0 AF-Q15208-K3 AGC_STK38_HUMAN AGC 2.2e-98 334.5 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38L ST38L_HUMAN AF-Q9Y2H1-K1A Q9Y2H1 82 391 464.0 No_ligand No_ligand Active DFGin 6.127 12.786 BLAminus DFGAsp-rot-in -135.9, 176.29 54.59, 71.07 200.8, 18.54 -77.78, 12.55 308.68, 110.86 -65.47, -15.43 in-in in 8.748 Saltbr-in 2.662 HRD-in -74.57, -52.73 67.15, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.54, 159.2 APE9-dihe-na 119.39, -179.63 APE8-dihe-in -97.35, 134.6 APE8-rot-in 300.97 APE67-dihe-in -77.2, -21.12 -50.84, -38.72 APE12-dist-in 8.643 APE11-dist-in 11.648 APE10-dist-in 5.779 APE9-dist-in 3.322 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[90, 383]] 1.0 AF-Q9Y2H1-K1 AGC_STK38L_HUMAN AGC 3.7e-100 340.3 1 260 260 230 231 232 234 236 119 138 142 210 212 211 213 305 293 288 287 286 285 284 283 282 168 Serine/threonine-protein kinase 38-like
AGC STK38L ST38L_HUMAN AF-Q9Y2H1-K3A Q9Y2H1 82 391 464.0 No_ligand No_ligand Active DFGin 6.169 13.097 BLAminus DFGAsp-rot-in -140.06, -179.59 52.1, 63.03 202.52, 14.63 -72.36, 13.02 306.88, 105.07 -64.09, -17.83 in-in in 8.911 Saltbr-in 2.671 HRD-in -72.91, -53.66 69.03, 2.42 in-in-in SNCiii in-in ActLoopNT-in 3.018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.96, 156.91 APE9-dihe-na 124.62, -179.56 APE8-dihe-in -90.79, 126.38 APE8-rot-in 299.46 APE67-dihe-in -69.46, -22.27 -47.42, -42.82 APE12-dist-in 8.765 APE11-dist-in 11.486 APE10-dist-in 5.626 APE9-dist-in 3.193 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[90, 383]] 1.0 AF-Q9Y2H1-K3 AGC_STK38L_HUMAN AGC 3.7e-100 340.3 1 260 260 230 231 232 234 236 119 138 142 210 212 211 213 305 293 288 287 286 285 284 283 282 168 Serine/threonine-protein kinase 38-like
CAMK AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.578 15.096 BLAminus DFGAsp-rot-in -139.2, -172.08 52.22, 80.16 196.46, -3.74 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.451 Saltbr-in 2.912 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.174 APE11-dist-in 10.957 APE10-dist-in 5.274 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282 266 0 0 0 0 [[133, 383]] 1.0 1ol5 CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.318 15.07 BLAminus DFGAsp-rot-in -133.54, 176.05 56.91, 81.54 195.86, -1.23 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.884 Saltbr-in 2.954 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.517 APE11-dist-in 11.427 APE10-dist-in 5.724 APE9-dist-in 3.833 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292 267 0 0 0 0 [[133, 383]] 1.0 6vpg CAMK_AURKA_HUMAN CAMK 8.6e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.391 14.976 BLAminus DFGAsp-rot-in -135.45, -179.78 54.7, 80.97 184.07, 19.2 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.247 Saltbr-in 2.724 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.257 APE11-dist-in 10.692 APE10-dist-in 5.213 APE9-dist-in 3.298 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283 267 0 0 0 0 [[133, 383]] 1.0 5lxm CAMK_AURKA_HUMAN CAMK 9.5e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.343 15.03 BLAminus DFGAsp-rot-in -132.86, -170.57 52.68, 76.5 207.99, -10.47 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.278 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.247 APE11-dist-in 10.799 APE10-dist-in 5.53 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285 264 0 0 0 0 [[133, 383]] 1.0 5g1x CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.623 15.108 BLAminus DFGAsp-rot-in -131.55, 179.55 58.91, 75.38 190.02, 0.89 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.225 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.126 APE11-dist-in 10.601 APE10-dist-in 5.354 APE9-dist-in 3.765 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309 264 0 0 0 0 [[133, 383]] 1.0 7ztl CAMK_AURKA_HUMAN CAMK 4.4e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN AF-O14965-K1A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.529 14.88 BLAminus DFGAsp-rot-in -132.48, -179.84 57.24, 70.17 206.24, 11.51 -79.24, 16.4 282.35, 77.01 -58.05, -32.04 in-in in 9.228 Saltbr-in 2.708 HRD-in -80.88, -51.09 67.96, 12.7 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.18, 173.11 APE9-dihe-na 86.42, -161.65 APE8-dihe-in -116.22, 122.78 APE8-rot-in 305.5 APE67-dihe-in -58.7, -20.28 -46.82, -49.92 APE12-dist-in 8.431 APE11-dist-in 11.227 APE10-dist-in 5.556 APE9-dist-in 3.551 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[133, 383]] 1.0 AF-O14965-K1 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN AF-O14965-K3A O14965 125 391 403.0 No_ligand No_ligand Active DFGin 5.698 15.216 BLAminus DFGAsp-rot-in -127.1, 175.03 53.67, 75.17 207.52, -28.4 -77.09, 18.89 286.79, 79.82 -57.24, -36.78 in-in in 9.953 Saltbr-in 2.826 HRD-in -82.42, -50.55 68.17, 14.97 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.94, 160.76 APE9-dihe-na 99.46, -154.48 APE8-dihe-in -120.71, 133.3 APE8-rot-in 307.63 APE67-dihe-in -63.76, -17.86 -47.79, -50.9 APE12-dist-in 8.761 APE11-dist-in 11.283 APE10-dist-in 5.572 APE9-dist-in 3.588 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[133, 383]] 1.0 AF-O14965-K3 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKB AURKB_HUMAN AF-Q96GD4-K1A Q96GD4 69 335 344.0 No_ligand No_ligand Active DFGin 5.78 15.026 BLAminus DFGAsp-rot-in -127.0, 176.5 57.8, 71.92 206.17, 19.23 -79.61, 19.08 285.14, 75.28 -59.65, -34.69 in-in in 9.481 Saltbr-in 2.704 HRD-in -78.88, -50.69 66.99, 11.13 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.14, 164.25 APE9-dihe-na 101.07, -163.18 APE8-dihe-in -106.28, 136.6 APE8-rot-in 304.12 APE67-dihe-in -69.73, -13.69 -45.42, -54.05 APE12-dist-in 8.572 APE11-dist-in 11.389 APE10-dist-in 5.657 APE9-dist-in 3.574 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[77, 327]] 1.0 AF-Q96GD4-K1 CAMK_AURKB_HUMAN CAMK 4.4e-80 274.7 1 256 256 217 218 219 221 223 106 125 129 197 199 198 200 255 243 238 237 236 235 234 233 232 155 Aurora kinase B
CAMK AURKB AURKB_HUMAN AF-Q96GD4-K3A Q96GD4 69 335 344.0 No_ligand No_ligand Active DFGin 5.577 14.992 BLAminus DFGAsp-rot-in -124.01, 179.54 50.32, 77.12 202.96, -18.4 -79.4, 14.41 288.62, 84.9 -59.82, -34.0 out-in out 10.078 Saltbr-in 2.759 HRD-in -78.41, -50.15 69.96, -4.31 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.38, 153.11 APE9-dihe-na 117.94, -172.26 APE8-dihe-in -95.05, 139.82 APE8-rot-in 304.53 APE67-dihe-in -69.06, -14.73 -44.88, -56.87 APE12-dist-in 9.043 APE11-dist-in 11.573 APE10-dist-in 5.835 APE9-dist-in 3.918 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[77, 327]] 1.0 AF-Q96GD4-K3 CAMK_AURKB_HUMAN CAMK 4.4e-80 274.7 1 256 256 217 218 219 221 223 106 125 129 197 199 198 200 255 243 238 237 236 235 234 233 232 155 Aurora kinase B
CAMK AURKC AURKC_HUMAN AF-Q9UQB9-K1A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.635 15.076 BLAminus DFGAsp-rot-in -126.22, 175.58 57.82, 73.67 203.35, 26.53 -81.22, 19.26 286.92, 74.37 -59.64, -33.26 in-in in 9.616 Saltbr-in 2.696 HRD-in -77.09, -49.16 67.41, 4.37 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.86, 162.45 APE9-dihe-na 106.12, -161.9 APE8-dihe-in -104.75, 137.86 APE8-rot-in 305.41 APE67-dihe-in -68.53, -15.21 -46.94, -52.61 APE12-dist-in 8.552 APE11-dist-in 11.243 APE10-dist-in 5.523 APE9-dist-in 3.664 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[43, 293]] 1.0 AF-Q9UQB9-K1 CAMK_AURKC_HUMAN CAMK 6.7e-81 277.3 1 256 256 183 184 185 187 189 72 91 95 163 165 164 166 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
CAMK AURKC AURKC_HUMAN AF-Q9UQB9-K3A Q9UQB9 35 301 309.0 No_ligand No_ligand Active DFGin 5.747 15.172 BLAminus DFGAsp-rot-in -125.84, 175.88 53.66, 71.06 205.92, -19.04 -74.66, 15.01 288.03, 83.94 -57.4, -36.96 out-in out 10.097 Saltbr-in 2.787 HRD-in -76.36, -51.95 70.98, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.99, 160.92 APE9-dihe-na 96.02, -158.34 APE8-dihe-in -106.03, 137.86 APE8-rot-in 305.48 APE67-dihe-in -66.92, -15.31 -47.34, -55.42 APE12-dist-in 8.927 APE11-dist-in 11.39 APE10-dist-in 5.652 APE9-dist-in 3.769 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[43, 293]] 1.0 AF-Q9UQB9-K3 CAMK_AURKC_HUMAN CAMK 6.7e-81 277.3 1 256 256 183 184 185 187 189 72 91 95 163 165 164 166 221 209 204 203 202 201 200 199 198 121 Aurora kinase C
CAMK BRSK1 BRSK1_HUMAN AF-Q8TDC3-K1A Q8TDC3 26 293 778.0 No_ligand No_ligand Active DFGin 6.808 15.13 BLAminus DFGAsp-rot-in -121.81, 178.15 56.09, 71.26 198.68, 12.13 -82.5, 17.05 284.26, 75.57 -61.12, -27.49 in-in in 9.227 Saltbr-in 2.74 HRD-in -77.3, -46.5 65.05, 8.08 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.75, 175.55 APE9-dihe-na 93.85, 175.65 APE8-dihe-in -81.85, 131.23 APE8-rot-in 304.83 APE67-dihe-in -65.54, -24.1 -54.25, -36.56 APE12-dist-in 8.75 APE11-dist-in 11.05 APE10-dist-in 5.412 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[34, 285]] 1.0 AF-Q8TDC3-K1 CAMK_BRSK1_HUMAN CAMK 3.1e-92 314.5 1 256 256 173 174 175 177 179 63 81 85 153 155 154 156 213 200 195 194 193 192 191 190 189 111 Serine/threonine-protein kinase BRSK1
CAMK BRSK1 BRSK1_HUMAN AF-Q8TDC3-K3A Q8TDC3 26 293 778.0 No_ligand No_ligand Active DFGin 6.712 15.445 BLAminus DFGAsp-rot-in -124.89, 175.0 56.49, 69.07 200.65, -3.64 -77.65, 15.8 289.5, 78.28 -63.98, -19.77 in-in in 9.233 Saltbr-in 2.734 HRD-in -78.79, -46.74 65.49, -0.78 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, -176.69 APE9-dihe-na 91.16, 160.53 APE8-dihe-in -69.59, 133.66 APE8-rot-in 283.52 APE67-dihe-in -66.21, -25.9 -50.21, -36.42 APE12-dist-in 8.155 APE11-dist-in 11.132 APE10-dist-in 5.627 APE9-dist-in 3.585 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[34, 285]] 1.0 AF-Q8TDC3-K3 CAMK_BRSK1_HUMAN CAMK 3.1e-92 314.5 1 256 256 173 174 175 177 179 63 81 85 153 155 154 156 213 200 195 194 193 192 191 190 189 111 Serine/threonine-protein kinase BRSK1
CAMK BRSK2 BRSK2_HUMAN AF-Q8IWQ3-K1A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.755 15.139 BLAminus DFGAsp-rot-in -120.06, 176.45 55.43, 76.65 196.83, 9.32 -86.23, 17.08 284.49, 75.24 -61.34, -26.15 in-in in 9.211 Saltbr-in 2.723 HRD-in -77.84, -45.13 64.62, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.81, 174.5 APE9-dihe-na 96.2, 170.99 APE8-dihe-in -71.92, 131.75 APE8-rot-in 284.78 APE67-dihe-in -64.62, -25.5 -53.71, -37.53 APE12-dist-in 8.698 APE11-dist-in 11.037 APE10-dist-in 5.404 APE9-dist-in 3.56 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[19, 270]] 1.0 AF-Q8IWQ3-K1 CAMK_BRSK2_HUMAN CAMK 2.6e-90 308.2 1 256 256 158 159 160 162 164 48 66 70 138 140 139 141 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2
CAMK BRSK2 BRSK2_HUMAN AF-Q8IWQ3-K3A Q8IWQ3 11 278 736.0 No_ligand No_ligand Active DFGin 6.691 15.173 BLAminus DFGAsp-rot-in -125.49, 176.18 54.9, 67.65 202.34, 5.33 -75.8, 15.73 285.69, 75.39 -60.59, -24.71 in-in in 9.084 Saltbr-in 2.784 HRD-in -81.88, -46.37 65.68, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.02, -179.24 APE9-dihe-na 88.25, 169.54 APE8-dihe-in -84.0, 130.88 APE8-rot-in 303.39 APE67-dihe-in -65.92, -26.66 -51.03, -36.6 APE12-dist-in 8.393 APE11-dist-in 11.149 APE10-dist-in 5.564 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[19, 270]] 1.0 AF-Q8IWQ3-K3 CAMK_BRSK2_HUMAN CAMK 2.6e-90 308.2 1 256 256 158 159 160 162 164 48 66 70 138 140 139 141 198 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase BRSK2
CAMK CAMK1 KCC1A_HUMAN AF-Q14012-K1A Q14012 12 284 370.0 No_ligand No_ligand Active DFGin 7.039 14.431 BLAminus DFGAsp-rot-in -132.3, 178.79 56.92, 77.41 195.65, 19.27 -87.64, 15.18 286.59, 83.85 -61.28, -27.44 in-in in 9.583 Saltbr-in 2.712 HRD-in -75.76, -45.28 65.4, 7.12 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.83, 172.09 APE9-dihe-na 101.67, 170.8 APE8-dihe-in -82.09, 131.11 APE8-rot-in 303.03 APE67-dihe-in -75.19, -13.11 -44.35, -42.98 APE12-dist-in 9.298 APE11-dist-in 11.651 APE10-dist-in 5.955 APE9-dist-in 3.497 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[20, 276]] 1.0 AF-Q14012-K1 CAMK_CAMK1_HUMAN CAMK 5.3e-97 330.1 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN AF-Q14012-K3A Q14012 12 284 370.0 No_ligand No_ligand Active DFGin 6.581 14.414 BLAminus DFGAsp-rot-in -130.02, 178.51 53.52, 86.81 199.06, -3.63 -92.3, 12.6 289.08, 88.58 -61.48, -26.42 in-in in 9.533 Saltbr-in 2.727 HRD-in -78.79, -44.16 66.04, 7.08 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.64, 175.22 APE9-dihe-na 90.47, 179.28 APE8-dihe-in -92.1, 119.46 APE8-rot-in 305.28 APE67-dihe-in -64.75, -14.55 -32.68, -55.85 APE12-dist-in 9.042 APE11-dist-in 11.708 APE10-dist-in 6.014 APE9-dist-in 3.483 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[20, 276]] 1.0 AF-Q14012-K3 CAMK_CAMK1_HUMAN CAMK 5.3e-97 330.1 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1D KCC1D_HUMAN AF-Q8IU85-K1A Q8IU85 15 287 385.0 No_ligand No_ligand Active DFGin 7.023 14.388 BLAminus DFGAsp-rot-in -125.91, 179.82 54.16, 76.18 198.52, 21.55 -84.67, 15.12 286.97, 82.97 -60.81, -27.83 in-in in 9.529 Saltbr-in 2.738 HRD-in -73.45, -47.31 66.44, 1.49 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.8, 172.07 APE9-dihe-na 103.91, 170.45 APE8-dihe-in -82.31, 131.37 APE8-rot-in 303.36 APE67-dihe-in -74.0, -12.41 -43.3, -45.63 APE12-dist-in 9.335 APE11-dist-in 11.648 APE10-dist-in 5.964 APE9-dist-in 3.534 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[23, 279]] 1.0 AF-Q8IU85-K1 CAMK_CAMK1D_HUMAN CAMK 1.1e-99 338.9 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN AF-Q8IU85-K3A Q8IU85 15 287 385.0 No_ligand No_ligand Active DFGin 6.561 14.511 BLAminus DFGAsp-rot-in -131.99, 178.86 49.3, 86.01 201.46, -4.98 -90.33, 13.8 289.17, 84.92 -60.61, -28.9 in-in in 9.316 Saltbr-in 2.738 HRD-in -77.21, -45.23 66.57, 2.89 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.89, 171.93 APE9-dihe-na 88.98, -178.14 APE8-dihe-in -93.78, 123.13 APE8-rot-in 305.99 APE67-dihe-in -64.39, -14.73 -53.29, -37.9 APE12-dist-in 9.308 APE11-dist-in 11.792 APE10-dist-in 6.074 APE9-dist-in 3.538 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[23, 279]] 1.0 AF-Q8IU85-K3 CAMK_CAMK1D_HUMAN CAMK 1.1e-99 338.9 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1G KCC1G_HUMAN AF-Q96NX5-K1A Q96NX5 15 285 476.0 No_ligand No_ligand Active DFGin 7.056 14.338 BLAminus DFGAsp-rot-in -126.58, 179.85 56.39, 77.72 198.13, 16.56 -87.16, 15.63 287.82, 84.96 -60.45, -29.23 in-in in 9.447 Saltbr-in 2.71 HRD-in -74.86, -46.27 65.96, 8.65 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.84, 169.22 APE9-dihe-na 102.92, 169.72 APE8-dihe-in -81.73, 123.98 APE8-rot-in 303.38 APE67-dihe-in -70.91, -11.9 -37.09, -50.52 APE12-dist-in 9.447 APE11-dist-in 11.742 APE10-dist-in 6.027 APE9-dist-in 3.595 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[23, 277]] 1.0 AF-Q96NX5-K1 CAMK_CAMK1G_HUMAN CAMK 4.7e-95 323.7 2 256 255 163 164 165 167 169 52 68 72 140 142 141 143 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CAMK1G KCC1G_HUMAN AF-Q96NX5-K3A Q96NX5 15 285 476.0 No_ligand No_ligand Active DFGin 6.525 14.257 BLAminus DFGAsp-rot-in -129.17, -179.4 55.4, 81.07 202.94, 0.55 -88.62, 13.01 293.17, 88.91 -61.06, -29.49 in-in in 9.211 Saltbr-in 2.712 HRD-in -76.58, -45.99 66.65, 0.57 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.42, 177.26 APE9-dihe-na 91.59, 178.28 APE8-dihe-in -90.09, 127.83 APE8-rot-in 302.62 APE67-dihe-inflip 90.7, -32.17 -46.34, 142.38 APE12-dist-in 9.3 APE11-dist-in 11.794 APE10-dist-in 6.074 APE9-dist-in 3.483 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[23, 277]] 1.0 AF-Q96NX5-K3 CAMK_CAMK1G_HUMAN CAMK 4.7e-95 323.7 2 256 255 163 164 165 167 169 52 68 72 140 142 141 143 201 189 184 183 182 181 180 179 178 98 Calcium/calmodulin-dependent protein kinase type 1G
CAMK CAMK2A KCC2A_HUMAN 7UIRA Q9UQM7 7 274 478.0 ATP:302 ATPlike Active DFGin 6.045 15.107 BLAminus DFGAsp-rot-in -137.0, 179.68 44.28, 101.28 174.91, 78.75 -106.42, 24.78 295.79, 81.95 -53.14, -27.06 in-in in 9.85 Saltbr-in 3.466 HRD-in -74.22, -43.69 67.52, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.48, 156.41 APE9-dihe-na 131.95, -156.1 APE8-dihe-in -122.09, 129.91 APE8-rot-in 298.28 APE67-dihe-in -55.12, -36.11 -51.43, -40.3 APE12-dist-in 10.333 APE11-dist-in 11.793 APE10-dist-in 6.056 APE9-dist-in 3.425 D135N,Q223K None None XRAY 3.1 0.234 0.274 A 268 268 0 0 0 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.093 14.463 BLAminus DFGAsp-rot-in -136.84, -179.4 43.86, 99.82 186.2, 999.0 -105.8, 24.57 296.99, 81.24 -56.04, -26.17 in-in in 9.403 Saltbr-in 3.027 HRD-in -74.93, -42.65 67.84, 3.24 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.86, 157.92 APE9-dihe-na 132.59, -155.55 APE8-dihe-in -122.09, 129.05 APE8-rot-in 298.73 APE67-dihe-in -54.7, -35.97 -51.63, -40.47 APE12-dist-in 10.303 APE11-dist-in 11.733 APE10-dist-in 5.989 APE9-dist-in 3.504 D135N,Q223K None None XRAY 3.1 0.234 0.274 B 268 261 6 0 0 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.775 14.64 BLAminus DFGAsp-rot-in -129.88, 174.11 65.35, 73.67 194.2, -5.95 -96.28, 29.41 284.7, 81.79 -65.3, -26.47 in-in in 8.527 Saltbr-in 2.903 HRD-in -76.38, -51.72 77.74, -11.0 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.94, 142.69 APE9-dihe-na 139.08, -169.53 APE8-dihe-in -115.65, 123.25 APE8-rot-in 308.77 APE67-dihe-in -69.44, -15.11 -33.38, -56.34 APE12-dist-in 10.469 APE11-dist-in 11.397 APE10-dist-in 5.657 APE9-dist-in 3.521 D135N,Q223K None None XRAY 2.56 0.234 0.281 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujp CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN AF-Q9UQM7-K1A Q9UQM7 5 279 478.0 No_ligand No_ligand Active DFGin 6.488 14.315 BLAminus DFGAsp-rot-in -125.02, 173.38 53.51, 80.22 198.68, 16.46 -85.69, 18.65 289.06, 79.25 -60.63, -25.38 in-in in 8.898 Saltbr-in 2.702 HRD-in -73.35, -47.46 65.63, -1.47 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.72, 148.09 APE9-dihe-na 125.54, 170.94 APE8-dihe-in -88.92, 132.18 APE8-rot-in 302.3 APE67-dihe-in -70.6, -10.42 -44.59, -50.01 APE12-dist-in 10.478 APE11-dist-in 11.531 APE10-dist-in 5.755 APE9-dist-in 3.456 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[13, 271]] 1.0 AF-Q9UQM7-K1 CAMK_CAMK2A_HUMAN CAMK 1.1e-96 329.1 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN AF-Q9UQM7-K3A Q9UQM7 5 279 478.0 No_ligand No_ligand Active DFGin 6.191 13.905 BLAminus DFGAsp-rot-in -129.09, 176.81 54.38, 73.99 207.13, -13.18 -79.35, 15.21 294.98, 88.86 -61.22, -26.9 in-in in 9.017 Saltbr-in 2.715 HRD-in -74.96, -46.17 66.01, -1.86 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.93, 151.74 APE9-dihe-na 116.08, 172.73 APE8-dihe-in -91.09, 134.45 APE8-rot-in 297.0 APE67-dihe-in -70.49, -13.14 -45.84, -50.34 APE12-dist-in 10.43 APE11-dist-in 11.27 APE10-dist-in 5.606 APE9-dist-in 3.191 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[13, 271]] 1.0 AF-Q9UQM7-K3 CAMK_CAMK2A_HUMAN CAMK 1.1e-96 329.1 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 6VZKA Q9UQM7 7 274 478.0 No_ligand No_ligand Active DFGin 6.351 13.943 BLAminus DFGAsp-rot-in -134.11, -178.17 51.67, 87.56 196.42, -8.46 -98.04, 20.59 282.85, 84.39 -60.3, -28.86 in-in in 9.088 Saltbr-in 3.136 HRD-in -72.72, -60.29 84.66, -3.19 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.77, 146.91 APE9-dihe-na 134.03, -157.81 APE8-dihe-in -109.96, 122.28 APE8-rot-in 299.52 APE67-dihe-in -55.05, -26.94 -35.18, -55.5 APE12-dist-in 10.16 APE11-dist-in 11.717 APE10-dist-in 5.949 APE9-dist-in 3.748 D135N,Q223K None None XRAY 2.55 0.214 0.294 A 268 258 10 0 0 0 [[13, 271]] 1.0 6vzk CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIQA Q9UQM7 7 274 478.0 No_ligand No_ligand Active DFGin 6.449 15.084 BLAminus DFGAsp-rot-in -140.43, -178.97 55.68, 69.33 220.93, -78.78 -81.32, 13.56 293.24, 82.91 -55.86, -14.59 in-in in 9.369 Saltbr-in 3.241 HRD-in -63.79, -57.12 80.21, -18.13 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.13, 162.67 APE9-dihe-na 124.48, -161.06 APE8-dihe-in -101.59, 135.95 APE8-rot-in 309.11 APE67-dihe-in -59.39, -26.36 -49.73, -52.37 APE12-dist-in 10.776 APE11-dist-in 11.902 APE10-dist-in 6.319 APE9-dist-in 3.925 D135N,Q223K None None XRAY 3.11 0.261 0.309 A 268 268 0 0 0 0 [[13, 271]] 1.0 7uiq CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIQB Q9UQM7 8 273 478.0 No_ligand No_ligand Active DFGin 6.354 14.86 BLAminus DFGAsp-rot-in -135.8, -173.94 47.0, 72.56 219.67, -78.38 -81.17, 12.3 291.45, 79.85 -57.12, -13.89 in-in in 9.302 Saltbr-in 3.162 HRD-in -71.21, -53.55 83.02, -20.81 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.85, 162.27 APE9-dihe-na 122.54, -165.04 APE8-dihe-in -104.82, 139.66 APE8-rot-in 306.2 APE67-dihe-in -59.16, -25.74 -56.75, -47.86 APE12-dist-in 10.807 APE11-dist-in 11.867 APE10-dist-in 6.301 APE9-dist-in 4.027 D135N,Q223K None None XRAY 3.11 0.261 0.309 B 268 261 5 0 0 0 [[13, 271]] 1.0 7uiq CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.124 13.93 BLAminus DFGAsp-rot-in -130.3, 144.9 77.59, 104.3 207.91, -27.85 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.032 Saltbr-in 2.623 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.819 APE10-dist-in 5.993 APE9-dist-in 3.832 None None None XRAY 2.3 0.165 0.203 A 313 289 2 0 0 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.7e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.865 14.032 BLAminus DFGAsp-rot-in -131.92, 139.26 77.54, 110.88 202.88, -43.01 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.31 Saltbr-in 2.931 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.252 APE11-dist-in 11.756 APE10-dist-in 5.996 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313 292 0 0 0 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.7e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7KL0A Q9UQM7 7 274 478.0 UZD:301 Type1 Active DFGin 6.77 14.532 BLAminus DFGAsp-rot-in -136.67, 172.68 63.72, 78.54 199.82, -15.19 -95.13, 23.83 289.55, 78.47 -63.68, -26.92 in-in in 8.456 Saltbr-in 2.845 HRD-in -73.15, -49.92 78.5, -7.4 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 144.1 APE9-dihe-na 136.1, -171.7 APE8-dihe-in -113.97, 130.36 APE8-rot-in 302.39 APE67-dihe-in -62.47, -20.95 -39.79, -54.85 APE12-dist-in 10.297 APE11-dist-in 11.423 APE10-dist-in 5.714 APE9-dist-in 3.654 D135N,Q223K None None XRAY 2.4 0.209 0.258 A 268 268 0 0 0 0 [[13, 271]] 1.0 7kl0 CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7KL0B Q9UQM7 7 274 478.0 UZD:301 Type1 Active DFGin 6.749 14.557 BLAminus DFGAsp-rot-in -135.5, 169.63 63.85, 78.98 199.3, -16.77 -95.27, 24.21 290.21, 80.29 -65.31, -21.38 in-in in 8.502 Saltbr-in 2.899 HRD-in -76.54, -48.6 76.75, -5.26 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.75, 146.84 APE9-dihe-na 143.82, -168.2 APE8-dihe-in -112.24, 128.47 APE8-rot-in 302.73 APE67-dihe-in -64.12, -18.13 -40.1, -53.96 APE12-dist-in 10.262 APE11-dist-in 11.385 APE10-dist-in 5.689 APE9-dist-in 3.705 D135N,Q223K None None XRAY 2.4 0.209 0.258 B 268 268 0 0 0 0 [[13, 271]] 1.0 7kl0 CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJQA Q9UQM7 7 274 478.0 UZD:301 Type1 Active DFGin 6.71 14.596 BLAminus DFGAsp-rot-in -130.29, 166.42 66.39, 83.92 196.14, -13.97 -99.29, 27.12 288.6, 77.85 -63.43, -28.99 in-in in 8.503 Saltbr-in 2.716 HRD-in -69.37, -48.63 77.68, -9.72 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.38, 146.4 APE9-dihe-na 132.63, -170.13 APE8-dihe-in -113.98, 127.54 APE8-rot-in 302.91 APE67-dihe-in -64.79, -16.69 -37.21, -55.42 APE12-dist-in 10.39 APE11-dist-in 11.413 APE10-dist-in 5.693 APE9-dist-in 3.661 D135N,Q223K None None XRAY 2.25 0.222 0.271 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujq CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJQB Q9UQM7 7 274 478.0 UZD:301 Type1 Active DFGin 6.776 14.527 BLAminus DFGAsp-rot-in -130.71, 166.51 65.49, 84.45 196.73, -12.85 -98.57, 27.04 288.12, 79.65 -65.11, -27.34 in-in in 8.514 Saltbr-in 2.74 HRD-in -69.76, -48.69 76.31, -7.39 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.35, 149.36 APE9-dihe-na 136.2, -166.91 APE8-dihe-in -112.91, 126.09 APE8-rot-in 303.49 APE67-dihe-in -63.04, -16.99 -38.33, -54.23 APE12-dist-in 10.355 APE11-dist-in 11.469 APE10-dist-in 5.743 APE9-dist-in 3.69 D135N,Q223K None None XRAY 2.25 0.222 0.271 B 268 268 0 0 0 0 [[13, 271]] 1.0 7ujq CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 6X5GA Q9UQM7 7 274 478.0 BCN:303 Type1.5_Back Active DFGin 6.275 15.29 BLAminus DFGAsp-rot-in -137.39, 173.54 61.4, 81.65 200.65, -12.3 -93.04, 16.42 283.75, 82.3 -58.37, -20.82 in-in in 9.287 Saltbr-in 3.494 HRD-in -74.17, -48.17 75.9, -4.37 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.51, 141.58 APE9-dihe-na 134.3, -159.12 APE8-dihe-in -120.77, 126.02 APE8-rot-in 299.57 APE67-dihe-in -64.67, -15.46 -38.22, -55.61 APE12-dist-in 10.635 APE11-dist-in 11.558 APE10-dist-in 5.946 APE9-dist-in 3.621 D135N,Q223K None None XRAY 1.85 0.189 0.227 A 268 268 0 0 0 0 [[13, 271]] 1.0 6x5g CAMK_CAMK2A_HUMAN CAMK 9.6e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2B KCC2B_HUMAN AF-Q13554-K1A Q13554 6 280 666.0 No_ligand No_ligand Active DFGin 6.439 14.169 BLAminus DFGAsp-rot-in -122.94, 175.94 51.38, 80.81 197.27, 23.78 -86.65, 18.92 291.89, 81.54 -60.01, -26.85 in-in in 8.891 Saltbr-in 2.702 HRD-in -72.47, -46.45 66.36, -6.79 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.32, 148.11 APE9-dihe-na 126.08, 167.07 APE8-dihe-in -82.56, 133.32 APE8-rot-in 300.35 APE67-dihe-in -71.17, -10.54 -46.21, -49.92 APE12-dist-in 10.465 APE11-dist-in 11.589 APE10-dist-in 5.822 APE9-dist-in 3.507 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13554-K1 CAMK_CAMK2B_HUMAN CAMK 4.4e-96 327.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN AF-Q13554-K3A Q13554 6 280 666.0 No_ligand No_ligand Active DFGin 6.187 13.894 BLAminus DFGAsp-rot-in -129.49, 177.65 53.79, 73.56 206.54, -11.05 -79.14, 14.93 294.94, 89.19 -60.96, -26.71 in-in in 8.992 Saltbr-in 2.719 HRD-in -74.58, -46.46 66.15, -1.06 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.13, 151.97 APE9-dihe-na 117.28, 172.91 APE8-dihe-in -91.67, 133.66 APE8-rot-in 296.91 APE67-dihe-in -70.13, -13.31 -45.09, -50.58 APE12-dist-in 10.472 APE11-dist-in 11.261 APE10-dist-in 5.588 APE9-dist-in 3.18 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13554-K3 CAMK_CAMK2B_HUMAN CAMK 4.4e-96 327.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN 3BHHB Q13554 11 301 666.0 5CP:60600 Type1 Active DFGin 6.941 14.456 BLAminus DFGAsp-rot-in -117.2, 170.85 61.15, 83.16 199.89, -4.8 -97.72, 36.05 287.66, 74.53 -67.67, -38.54 in-in in 8.604 Saltbr-in 2.675 HRD-in -58.6, -51.5 66.61, 3.54 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -169.21, 142.03 APE9-dihe-na 119.94, 176.56 APE8-dihe-in -98.59, 132.55 APE8-rot-in 303.2 APE67-dihe-in -57.82, -18.36 -41.82, -57.14 APE12-dist-in 10.456 APE11-dist-in 11.076 APE10-dist-in 5.596 APE9-dist-in 3.692 None None None XRAY 2.4 0.225 0.275 B 295 288 3 0 0 0 [[14, 272]] 1.0 3bhh CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2D KCC2D_HUMAN AF-Q13557-K1A Q13557 6 280 499.0 No_ligand No_ligand Active DFGin 6.47 14.236 BLAminus DFGAsp-rot-in -122.26, 176.5 50.79, 79.83 196.88, 25.11 -85.93, 18.86 290.58, 80.69 -60.01, -28.02 in-in in 8.878 Saltbr-in 2.705 HRD-in -73.19, -46.14 66.59, -7.7 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 148.66 APE9-dihe-na 124.57, 167.11 APE8-dihe-in -82.49, 133.61 APE8-rot-in 301.15 APE67-dihe-in -70.6, -10.99 -46.16, -50.3 APE12-dist-in 10.441 APE11-dist-in 11.599 APE10-dist-in 5.843 APE9-dist-in 3.48 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13557-K1 CAMK_CAMK2D_HUMAN CAMK 2.3e-97 331.3 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN AF-Q13557-K3A Q13557 6 280 499.0 No_ligand No_ligand Active DFGin 6.31 14.319 BLAminus DFGAsp-rot-in -126.4466, 176.5794 54.8095, 72.0191 200.5874, 20.2725 -76.7401, 15.248 292.8837, 85.251 -60.3001, -27.5864 in-in in 8.916 Saltbr-in 2.713 HRD-in -75.5491, -46.9994 66.8207, 1.8664 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.7641, 148.15 APE9-dihe-na 113.9033, 169.3062 APE8-dihe-in -88.6864, 135.0834 APE8-rot-in 299.0295 APE67-dihe-in -70.136, -14.0716 -45.5568, -49.9534 APE12-dist-in 10.473 APE11-dist-in 11.087 APE10-dist-in 5.524 APE9-dist-in 3.197 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13557-K3 CAMK_CAMK2D_HUMAN CAMK 2.3e-97 331.3 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D D6R938_HUMAN 8USOB D6R938 6 475 498.0 No_ligand No_ligand Active DFGin 6.806 15.016 BLAminus DFGAsp-rot-in -127.5, 163.6 65.94, 89.59 202.36, -17.9 -102.38, 32.29 288.13, 79.86 -71.59, -19.82 in-in in 8.59 Saltbr-in 2.639 HRD-in -71.3, -50.05 77.65, -5.71 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.54, 150.5 APE9-dihe-na 136.44, -170.02 APE8-dihe-in -111.38, 131.33 APE8-rot-in 304.76 APE67-dihe-in -65.19, -20.1 -48.22, -47.04 APE12-dist-in 10.184 APE11-dist-in 11.895 APE10-dist-in 6.075 APE9-dist-in 3.619 D364C None None XRAY 2.3 0.185 0.213 B 450 436 0 0 0 0 [[14, 272]] 1.0 8uso CAMK_CAMK2D_HUMAN CAMK 1.2e-96 329.4 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 calcium/calmodulin-dependent protein kinase
CAMK CAMK2D KCC2D_HUMAN 9BLHA Q13557 11 301 499.0 6ZZ:400 Type1 Active DFGin 6.557 14.798 BLAminus DFGAsp-rot-in -126.09, 171.4 53.95, 91.02 202.54, -12.91 -97.64, 24.97 286.97, 77.72 -61.75, -25.83 in-in in 8.382 Saltbr-in 2.685 HRD-in -69.34, -46.51 75.56, -3.98 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.43, 148.15 APE9-dihe-na 136.6, -162.07 APE8-dihe-in -117.16, 133.77 APE8-rot-in 302.83 APE67-dihe-in -65.71, -19.8 -50.02, -46.22 APE12-dist-in 10.25 APE11-dist-in 11.703 APE10-dist-in 5.909 APE9-dist-in 3.695 None None None XRAY 2.35 0.201 0.251 A 300 291 0 0 0 0 [[14, 272]] 1.0 9blh CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 9BLHB Q13557 11 298 499.0 6ZZ:401 Type1 Active DFGin 6.707 14.726 BLAminus DFGAsp-rot-in -132.5, 166.89 59.11, 88.28 205.56, -23.21 -98.43, 27.58 287.41, 83.03 -66.65, -16.38 in-in in 8.373 Saltbr-in 2.905 HRD-in -69.19, -48.82 76.63, -7.07 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 154.85 APE9-dihe-na 124.25, -172.4 APE8-dihe-in -108.0, 132.6 APE8-rot-in 299.23 APE67-dihe-inflip 89.48, -27.26 -55.4, 149.02 APE12-dist-in 10.146 APE11-dist-in 11.85 APE10-dist-in 5.995 APE9-dist-in 3.583 None None None XRAY 2.35 0.201 0.251 B 300 288 0 0 0 0 [[14, 272]] 1.0 9blh CAMK_CAMK2D_HUMAN CAMK 3.2e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 2VN9A Q13557 10 309 499.0 GVD:61314 Type1 Active DFGin 6.59 14.614 BLAminus DFGAsp-rot-in -124.96, 171.71 55.2, 92.42 198.77, -22.54 -101.83, 28.41 288.28, 77.94 -66.41, -20.24 in-in in 9.242 Saltbr-in 2.843 HRD-in -68.47, -47.2 70.33, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.47, 140.91 APE9-dihe-na 137.94, -158.39 APE8-dihe-in -117.81, 127.62 APE8-rot-in 304.33 APE67-dihe-in -59.63, -25.55 -44.23, -52.64 APE12-dist-in 10.261 APE11-dist-in 11.912 APE10-dist-in 6.197 APE9-dist-in 3.798 None None None XRAY 2.3 0.213 0.248 A 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 2VN9B Q13557 10 309 499.0 GVD:61310 Type1 Active DFGin 6.551 14.602 BLAminus DFGAsp-rot-in -127.37, 171.91 57.38, 92.45 199.7, -19.65 -101.92, 22.76 286.58, 76.44 -61.0, -20.5 in-in in 9.266 Saltbr-in 2.869 HRD-in -69.29, -46.65 68.24, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.29, 141.49 APE9-dihe-na 142.44, -161.34 APE8-dihe-in -114.21, 127.94 APE8-rot-in 302.01 APE67-dihe-in -63.28, -20.34 -43.86, -50.83 APE12-dist-in 10.34 APE11-dist-in 11.874 APE10-dist-in 6.184 APE9-dist-in 3.738 None None None XRAY 2.3 0.213 0.248 B 301 300 0 0 0 0 [[14, 272]] 1.0 2vn9 CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 5VLOA Q13557 8 300 499.0 9EJ:401 Type1 Active DFGin 6.706 13.878 BLAminus DFGAsp-rot-in -130.05, 160.81 64.78, 109.07 199.23, -32.65 -117.58, 29.14 292.75, 86.52 -65.37, -22.87 in-in in 8.775 Saltbr-in 2.449 HRD-in -65.49, -44.36 73.72, -7.68 in-in-in SNCiii in-in ActLoopNT-in 3.01 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.47, 145.71 APE9-dihe-na 128.02, 178.51 APE8-dihe-in -112.02, 134.64 APE8-rot-in 309.42 APE67-dihe-in -64.14, -15.28 -42.07, -53.64 APE12-dist-in 10.859 APE11-dist-in 11.037 APE10-dist-in 5.888 APE9-dist-in 3.642 None None None XRAY 2.05 0.184 0.226 A 302 290 3 0 0 0 [[14, 272]] 1.0 5vlo CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 5VLOB Q13557 7 299 499.0 9EJ:401 Type1 Active DFGin 6.484 13.904 BLAminus DFGAsp-rot-in -134.01, 166.26 64.06, 99.6 204.67, -33.46 -109.74, 31.17 294.26, 89.58 -69.03, -23.87 in-in in 8.824 Saltbr-in 2.639 HRD-in -72.23, -47.02 74.68, -1.49 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.65, 146.65 APE9-dihe-na 120.86, -178.91 APE8-dihe-in -104.42, 135.12 APE8-rot-in 295.71 APE67-dihe-in -65.09, -10.9 -46.09, -51.75 APE12-dist-in 10.632 APE11-dist-in 10.897 APE10-dist-in 5.457 APE9-dist-in 3.347 None None None XRAY 2.05 0.184 0.226 B 302 293 0 0 0 0 [[14, 272]] 1.0 5vlo CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 6AYWA Q13557 8 300 499.0 C2V:401 Type1 Active DFGin 6.798 14.013 BLAminus DFGAsp-rot-in -129.66, 162.48 66.98, 94.93 202.78, -6.24 -102.18, 23.06 289.39, 86.24 -60.21, -25.31 in-in in 8.729 Saltbr-in 2.618 HRD-in -76.7, -45.04 76.44, -3.66 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.63, 143.06 APE9-dihe-na 136.95, 172.55 APE8-dihe-in -110.09, 132.94 APE8-rot-in 297.48 APE67-dihe-in -62.77, -18.19 -52.65, -46.68 APE12-dist-in 10.672 APE11-dist-in 11.217 APE10-dist-in 5.815 APE9-dist-in 3.585 None None None XRAY 2.05 0.202 0.267 A 302 293 0 0 0 0 [[14, 272]] 1.0 6ayw CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2D KCC2D_HUMAN 6AYWB Q13557 7 299 499.0 C2V:402 Type1 Active DFGin 6.584 13.97 BLAminus DFGAsp-rot-in -126.53, 171.85 60.28, 89.59 204.15, -20.86 -97.82, 25.08 291.27, 84.52 -59.0, -26.52 in-in in 8.56 Saltbr-in 2.653 HRD-in -72.96, -48.66 76.86, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.64, 142.07 APE9-dihe-na 121.32, -174.92 APE8-dihe-in -105.07, 134.99 APE8-rot-in 288.9 APE67-dihe-in -65.78, -11.98 -46.42, -51.9 APE12-dist-in 10.672 APE11-dist-in 11.089 APE10-dist-in 5.676 APE9-dist-in 3.603 None None None XRAY 2.05 0.202 0.267 B 302 293 0 0 0 0 [[14, 272]] 1.0 6ayw CAMK_CAMK2D_HUMAN CAMK 3.3e-97 330.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit delta
CAMK CAMK2G KCC2G_HUMAN AF-Q13555-K1A Q13555 6 280 558.0 No_ligand No_ligand Active DFGin 6.541 14.189 BLAminus DFGAsp-rot-in -123.54, 175.26 50.68, 80.23 196.95, 22.74 -84.85, 18.78 290.3, 82.49 -60.28, -26.7 in-in in 8.856 Saltbr-in 2.701 HRD-in -71.7, -47.07 66.54, -6.54 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.06, 148.84 APE9-dihe-na 126.1, 167.76 APE8-dihe-in -82.5, 132.78 APE8-rot-in 301.25 APE67-dihe-in -70.93, -10.21 -46.47, -49.41 APE12-dist-in 10.474 APE11-dist-in 11.619 APE10-dist-in 5.84 APE9-dist-in 3.492 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13555-K1 CAMK_CAMK2G_HUMAN CAMK 2.6e-97 331.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit gamma
CAMK CAMK2G KCC2G_HUMAN AF-Q13555-K3A Q13555 6 280 558.0 No_ligand No_ligand Active DFGin 6.22 14.029 BLAminus DFGAsp-rot-in -131.4473, 176.0329 56.0151, 70.1184 206.5489, -4.8352 -75.7385, 14.5047 293.7596, 89.4902 -61.2435, -25.8143 in-in in 8.982 Saltbr-in 2.714 HRD-in -74.1308, -46.6458 64.595, 11.4055 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.569, 151.2212 APE9-dihe-na 115.9642, 173.0638 APE8-dihe-in -91.3956, 134.4834 APE8-rot-in 297.3657 APE67-dihe-in -70.7533, -13.3186 -45.836, -50.3632 APE12-dist-in 10.491 APE11-dist-in 11.303 APE10-dist-in 5.643 APE9-dist-in 3.11 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[14, 272]] 1.0 AF-Q13555-K3 CAMK_CAMK2G_HUMAN CAMK 2.6e-97 331.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit gamma
CAMK CAMK2G KCC2G_HUMAN 2V7OA Q13555 3 302 558.0 DRN:61303 Type1 Active DFGin 6.908 14.673 BLAminus DFGAsp-rot-in -130.63, 164.18 65.17, 81.92 196.99, -9.06 -95.2, 27.9 289.49, 72.67 -63.32, -23.54 in-in in 8.743 Saltbr-in 2.9 HRD-in -67.36, -44.98 69.88, -1.77 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 165.01 APE9-dihe-na 121.7, -166.92 APE8-dihe-in -121.46, 129.64 APE8-rot-in 300.61 APE67-dihe-in -66.88, -19.12 -32.46, -61.77 APE12-dist-in 10.496 APE11-dist-in 11.752 APE10-dist-in 5.945 APE9-dist-in 3.538 None SEP3 SEP3 XRAY 2.25 0.179 0.241 A 336 299 1 0 0 0 [[14, 272]] 1.0 2v7o CAMK_CAMK2G_HUMAN CAMK 2.2e-96 328.3 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit gamma
CAMK CAMK4 KCC4_HUMAN AF-Q16566-K1A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.831 14.023 BLAminus DFGAsp-rot-in -124.46, 176.48 55.21, 77.24 199.64, 17.29 -84.68, 15.91 287.09, 84.48 -62.02, -27.43 in-in in 9.046 Saltbr-in 2.7 HRD-in -73.53, -48.06 65.28, 7.09 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.19, 170.22 APE9-dihe-na 100.17, 171.33 APE8-dihe-in -80.42, 124.09 APE8-rot-in 304.98 APE67-dihe-in -65.57, -17.88 -39.32, -52.52 APE12-dist-in 9.143 APE11-dist-in 11.662 APE10-dist-in 5.979 APE9-dist-in 3.546 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[46, 300]] 1.0 AF-Q16566-K1 CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1 256 256 184 185 186 188 190 75 89 93 161 163 162 164 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK CAMK4 KCC4_HUMAN AF-Q16566-K3A Q16566 38 308 473.0 No_ligand No_ligand Active DFGin 6.407 13.934 BLAminus DFGAsp-rot-in -126.57, 176.47 50.26, 85.3 205.16, -9.67 -89.34, 16.16 296.27, 90.91 -58.07, -37.2 in-in in 8.766 Saltbr-in 2.682 HRD-in -76.87, -46.3 67.64, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.73, 178.0 APE9-dihe-na 87.53, 176.04 APE8-dihe-in -85.64, 118.83 APE8-rot-in 305.77 APE67-dihe-in -59.67, -22.63 -41.18, -50.68 APE12-dist-in 8.597 APE11-dist-in 11.47 APE10-dist-in 5.827 APE9-dist-in 3.673 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[46, 300]] 1.0 AF-Q16566-K3 CAMK_CAMK4_HUMAN CAMK 2e-90 308.5 1 256 256 184 185 186 188 190 75 89 93 161 163 162 164 223 211 206 205 204 203 202 201 200 119 Calcium/calmodulin-dependent protein kinase type IV
CAMK CAMKK1 KKCC1_HUMAN AF-Q8N5S9-K1A Q8N5S9 120 417 505.0 No_ligand No_ligand Active DFGin 6.64 14.214 BLAminus DFGAsp-rot-in -134.18, 176.13 57.67, 68.23 205.12, 21.75 -76.68, 15.05 286.1, 82.26 -63.87, -22.3 in-in in 9.591 Saltbr-in 2.75 HRD-in -76.9, -46.59 67.65, 9.87 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.49, 167.08 APE9-dihe-na 102.33, -175.41 APE8-dihe-in -78.51, 125.96 APE8-rot-in 304.65 APE67-dihe-in -68.39, -11.44 -51.39, -42.96 APE12-dist-in 9.697 APE11-dist-in 11.261 APE10-dist-in 5.559 APE9-dist-in 3.483 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[128, 409]] 1.0 AF-Q8N5S9-K1 CAMK_CAMKK1_HUMAN CAMK 7.5e-70 241.2 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK1 KKCC1_HUMAN AF-Q8N5S9-K3A Q8N5S9 120 417 505.0 No_ligand No_ligand Active DFGin 6.398 14.388 BLAminus DFGAsp-rot-in -130.13, 173.81 56.4, 81.06 196.31, 4.59 -85.49, 15.87 290.57, 83.79 -65.29, -12.15 in-in in 9.446 Saltbr-in 2.728 HRD-in -79.18, -45.45 72.5, -1.3 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.02, 163.83 APE9-dihe-na 95.29, -166.77 APE8-dihe-in -91.16, 125.45 APE8-rot-in 306.15 APE67-dihe-in -69.07, -14.47 -51.98, -41.22 APE12-dist-in 9.7 APE11-dist-in 10.825 APE10-dist-in 5.151 APE9-dist-in 3.763 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[128, 409]] 1.0 AF-Q8N5S9-K3 CAMK_CAMKK1_HUMAN CAMK 7.5e-70 241.2 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK1 KKCC1_HUMAN 6CD6A Q8N5S9 125 411 505.0 DXV:60501 Type1 Active DFGin 6.878 14.135 BLAminus DFGAsp-rot-in -124.7, 170.28 68.74, 89.07 194.55, -9.75 -100.88, 41.03 286.2, 85.63 -77.55, -31.83 in-in in 9.621 Saltbr-in 2.671 HRD-in -82.81, -48.53 77.66, 1.72 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.62, 153.69 APE9-dihe-na 94.1, -152.78 APE8-dihe-in -98.07, 126.87 APE8-rot-in 318.36 APE67-dihe-in -57.43, -20.29 -43.85, -51.81 APE12-dist-in 10.74 APE11-dist-in 10.677 APE10-dist-in 5.177 APE9-dist-in 3.66 None None None XRAY 2.2 0.235 0.285 A 290 264 23 0 0 0 [[128, 409]] 1.0 6cd6 CAMK_CAMKK1_HUMAN CAMK 6.8e-70 241.4 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK1 KKCC1_HUMAN 6CD6B Q8N5S9 124 411 505.0 DXV:60501 Type1 Active DFGin 6.841 14.025 BLAminus DFGAsp-rot-in -138.49, 175.5 64.46, 79.43 198.21, -8.76 -94.12, 38.89 287.63, 83.15 -75.07, -25.81 in-in in 9.511 Saltbr-in 2.931 HRD-in -77.13, -48.72 74.63, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.49, 157.62 APE9-dihe-na 92.05, -161.89 APE8-dihe-in -86.81, 123.44 APE8-rot-in 314.34 APE67-dihe-in -59.1, -23.14 -49.93, -46.53 APE12-dist-in 10.731 APE11-dist-in 10.614 APE10-dist-in 5.035 APE9-dist-in 3.744 None None None XRAY 2.2 0.235 0.285 B 290 265 23 0 0 0 [[128, 409]] 1.0 6cd6 CAMK_CAMKK1_HUMAN CAMK 6.8e-70 241.4 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK1 KKCC1_HUMAN 6CD6C Q8N5S9 124 411 505.0 DXV:60501 Type1 Active DFGin 6.754 14.06 BLAminus DFGAsp-rot-in -125.59, 173.52 66.96, 89.07 194.56, -11.2 -101.14, 30.16 286.44, 84.59 -67.54, -26.14 in-in in 9.438 Saltbr-in 2.769 HRD-in -82.03, -46.2 76.79, -1.49 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.12, 152.08 APE9-dihe-na 101.33, -153.4 APE8-dihe-in -96.17, 131.43 APE8-rot-in 317.04 APE67-dihe-in -59.44, -17.08 -48.23, -52.17 APE12-dist-in 10.197 APE11-dist-in 10.654 APE10-dist-in 5.245 APE9-dist-in 3.741 None None None XRAY 2.2 0.235 0.285 C 290 265 23 0 0 0 [[128, 409]] 1.0 6cd6 CAMK_CAMKK1_HUMAN CAMK 6.8e-70 241.4 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK1 KKCC1_HUMAN 6CD6D Q8N5S9 124 411 505.0 DXV:60501 Type1 Active DFGin 6.761 14.114 BLAminus DFGAsp-rot-in -143.58, 179.74 61.9, 77.61 198.57, -7.41 -90.69, 32.26 285.59, 84.09 -71.76, -23.95 in-in in 9.486 Saltbr-in 2.803 HRD-in -81.33, -48.85 75.88, 1.51 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 160.09 APE9-dihe-na 92.04, -164.3 APE8-dihe-in -82.45, 123.48 APE8-rot-in 318.0 APE67-dihe-in -57.36, -25.13 -49.42, -47.09 APE12-dist-in 10.926 APE11-dist-in 10.977 APE10-dist-in 5.378 APE9-dist-in 3.766 None None None XRAY 2.2 0.235 0.285 D 290 266 22 0 0 0 [[128, 409]] 1.0 6cd6 CAMK_CAMKK1_HUMAN CAMK 6.8e-70 241.4 1 256 256 292 293 294 296 298 157 199 203 272 274 273 275 335 320 315 314 313 312 311 310 309 231 Calcium/calmodulin-dependent protein kinase kinase 1
CAMK CAMKK2 KKCC2_HUMAN AF-Q96RR4-K1A Q96RR4 157 454 588.0 No_ligand No_ligand Active DFGin 6.665 14.169 BLAminus DFGAsp-rot-in -132.44, 175.99 57.36, 68.16 203.91, 27.78 -76.57, 14.76 286.1, 81.79 -62.55, -23.22 in-in in 9.394 Saltbr-in 2.695 HRD-in -79.64, -48.25 68.82, -0.98 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.01, 169.11 APE9-dihe-na 104.28, -176.67 APE8-dihe-in -78.12, 125.37 APE8-rot-in 303.5 APE67-dihe-in -69.04, -13.45 -51.83, -41.76 APE12-dist-in 10.041 APE11-dist-in 11.409 APE10-dist-in 5.575 APE9-dist-in 3.675 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[165, 446]] 1.0 AF-Q96RR4-K1 CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN AF-Q96RR4-K3A Q96RR4 157 454 588.0 No_ligand No_ligand Active DFGin 6.467 14.428 BLAminus DFGAsp-rot-in -128.41, 174.74 57.05, 81.6 194.54, 8.92 -88.18, 14.62 288.81, 81.28 -63.4, -16.07 in-in in 9.319 Saltbr-in 2.712 HRD-in -77.71, -48.64 72.76, -3.48 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.55, 162.31 APE9-dihe-na 106.94, -168.52 APE8-dihe-in -85.81, 124.48 APE8-rot-in 304.61 APE67-dihe-in -68.71, -15.46 -52.27, -41.23 APE12-dist-in 9.83 APE11-dist-in 11.286 APE10-dist-in 5.521 APE9-dist-in 3.906 None None None AF2 -1.0 1.0 1.0 A 298 298 0 0 0 0 [[165, 446]] 1.0 AF-Q96RR4-K3 CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6CMJA Q96RR4 161 463 588.0 F6J:60501 Type1 Active DFGin 6.701 14.021 BLAminus DFGAsp-rot-in -128.16, 173.53 66.84, 86.55 204.57, -17.32 -100.45, 21.53 286.63, 76.45 -58.11, -34.47 in-in in 9.516 Saltbr-in 2.708 HRD-in -70.27, -50.6 73.87, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 163.41 APE9-dihe-na 103.64, -157.45 APE8-dihe-in -90.88, 126.33 APE8-rot-in 303.07 APE67-dihe-in -67.03, -16.03 -51.77, -42.09 APE12-dist-in 9.98 APE11-dist-in 11.134 APE10-dist-in 5.259 APE9-dist-in 3.817 None SEP345,SEP400,TPO462 SEP345,SEP400,TPO462 XRAY 2.4 0.184 0.219 A 321 288 0 0 0 0 [[165, 446]] 1.0 6cmj CAMK_CAMKK2_HUMAN CAMK 2.5e-75 259.1 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6CMJB Q96RR4 161 462 588.0 F6J:60501 Type1 Active DFGin 6.554 14.022 BLAminus DFGAsp-rot-in -126.23, 173.65 67.8, 86.78 204.48, -19.99 -100.71, 20.95 284.77, 76.92 -57.77, -33.94 in-in in 9.471 Saltbr-in 2.703 HRD-in -69.56, -50.79 72.39, 3.04 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.14, 163.72 APE9-dihe-na 103.15, -157.71 APE8-dihe-in -91.26, 126.78 APE8-rot-in 302.39 APE67-dihe-in -66.21, -16.47 -51.31, -43.01 APE12-dist-in 9.849 APE11-dist-in 11.082 APE10-dist-in 5.224 APE9-dist-in 3.82 None SEP345,SEP400,TPO462 SEP345,SEP400,TPO462 XRAY 2.4 0.184 0.219 B 321 287 0 0 0 0 [[165, 446]] 1.0 6cmj CAMK_CAMKK2_HUMAN CAMK 2.5e-75 259.1 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5UY6A Q96RR4 161 448 588.0 8R4:60501 Type1 Active DFGin 6.658 14.113 BLAminus DFGAsp-rot-in -132.25, 178.64 58.27, 80.64 198.44, -19.62 -92.28, 18.22 280.67, 75.88 -55.42, -33.9 in-in in 9.414 Saltbr-in 2.807 HRD-in -79.1, -48.26 75.47, 2.11 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.81, 164.34 APE9-dihe-na 164.84, 175.43 APE8-dihe-in -85.88, 125.38 APE8-rot-in 293.83 APE67-dihe-in -66.95, -13.04 -45.29, -49.63 APE12-dist-in 12.905 APE11-dist-in 9.434 APE10-dist-in 5.805 APE9-dist-in 3.699 None None None XRAY 1.7 0.161 0.182 A 291 280 8 0 0 0 [[165, 446]] 1.0 5uy6 CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5UYJA Q96RR4 161 449 588.0 8R7:60501 Type1 Active DFGin 6.677 14.259 BLAminus DFGAsp-rot-in -132.08, 177.07 61.37, 75.95 200.85, -16.02 -92.03, 18.28 280.27, 75.86 -52.8, -33.56 in-in in 9.609 Saltbr-in 2.819 HRD-in -81.51, -46.94 74.7, -2.01 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.8, 177.18 APE9-dihe-na 146.73, 172.64 APE8-dihe-in -82.87, 120.29 APE8-rot-in 300.04 APE67-dihe-in -68.29, -15.78 -49.75, -38.95 APE12-dist-in 13.135 APE11-dist-in 9.542 APE10-dist-in 5.877 APE9-dist-in 3.8 None None None XRAY 1.6 0.154 0.171 A 291 279 10 0 0 0 [[165, 446]] 1.0 5uyj CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5VT1A Q96RR4 161 448 588.0 9JS:60501 Type1 Active DFGin 6.546 15.55 BLAminus DFGAsp-rot-in -132.63, 175.89 60.91, 78.93 203.66, -23.56 -96.17, 18.34 289.68, 79.81 -58.68, -37.7 in-in in 9.551 Saltbr-in 2.749 HRD-in -65.51, -51.56 73.13, -0.26 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.36, 161.23 APE9-dihe-na 117.82, -160.36 APE8-dihe-in -95.25, 124.59 APE8-rot-in 296.31 APE67-dihe-in -61.09, -17.48 -48.27, -47.93 APE12-dist-in 9.741 APE11-dist-in 11.275 APE10-dist-in 5.375 APE9-dist-in 3.72 None None None XRAY 1.9 0.162 0.185 A 291 264 24 0 0 0 [[165, 446]] 1.0 5vt1 CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BKUA Q96RR4 162 448 588.0 DXV:60501 Type1 Active DFGin 6.671 13.993 BLAminus DFGAsp-rot-in -127.33, 174.32 63.79, 82.42 194.65, -13.21 -93.37, 15.83 286.48, 75.23 -60.79, -22.1 in-in in 9.376 Saltbr-in 2.778 HRD-in -78.88, -49.79 72.64, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.85, 136.95 APE9-dihe-na -173.19, 179.59 APE8-dihe-in -86.46, 122.73 APE8-rot-in 300.93 APE67-dihe-in -60.17, -23.84 -48.28, -46.85 APE12-dist-in 12.68 APE11-dist-in 9.268 APE10-dist-in 5.511 APE9-dist-in 3.673 None None None XRAY 2.0 0.195 0.237 A 291 264 23 0 0 0 [[165, 446]] 1.0 6bku CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BLEA Q96RR4 161 448 588.0 34U:60501 Type1 Active DFGin 6.944 13.935 BLAminus DFGAsp-rot-in -128.26, 170.03 71.11, 85.91 203.88, -16.12 -96.22, 21.85 288.46, 75.34 -64.75, -26.18 in-in in 9.44 Saltbr-in 2.979 HRD-in -71.71, -49.79 72.3, -0.91 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.97, 170.59 APE9-dihe-na 108.12, -153.2 APE8-dihe-in -104.48, 120.4 APE8-rot-in 301.26 APE67-dihe-in -69.03, -15.32 -42.71, -45.39 APE12-dist-in 9.752 APE11-dist-in 11.249 APE10-dist-in 5.436 APE9-dist-in 3.784 None None None XRAY 1.9 0.188 0.227 A 291 263 25 0 0 0 [[165, 446]] 1.0 6ble CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BQLA Q96RR4 161 448 588.0 BI9:60501 Type1 Active DFGin 6.775 15.905 BLAminus DFGAsp-rot-in -125.08, 172.02 71.12, 81.11 186.72, 8.72 -96.1, 13.43 287.91, 80.94 -58.33, -35.96 in-in in 9.654 Saltbr-in 3.536 HRD-in -69.05, -49.88 71.03, 0.77 in-in-in SNCiii in-in ActLoopNT-in 2.758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.45, 168.13 APE9-dihe-na 102.75, -153.47 APE8-dihe-in -100.87, 121.4 APE8-rot-in 299.55 APE67-dihe-in -62.51, -19.42 -46.16, -47.04 APE12-dist-in 9.501 APE11-dist-in 11.237 APE10-dist-in 5.346 APE9-dist-in 3.607 None None None XRAY 2.0 0.189 0.225 A 291 276 12 0 0 0 [[165, 446]] 1.0 6bql CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BQPA Q96RR4 161 448 588.0 6T2:60501 Type1 Active DFGin 6.879 13.941 BLAminus DFGAsp-rot-in -127.73, 165.94 70.2, 92.8 199.42, -12.69 -98.65, 20.48 287.69, 73.18 -57.53, -31.21 in-in in 9.397 Saltbr-in 2.884 HRD-in -64.73, -48.51 76.52, -1.98 in-in-in SNCiii in-in ActLoopNT-in 2.758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.24, 171.23 APE9-dihe-na 110.1, -156.68 APE8-dihe-in -100.02, 128.5 APE8-rot-in 305.22 APE67-dihe-in -65.8, -14.31 -55.35, -41.21 APE12-dist-in 9.588 APE11-dist-in 11.269 APE10-dist-in 5.453 APE9-dist-in 3.477 None None None XRAY 1.95 0.191 0.227 A 291 262 26 0 0 0 [[165, 446]] 1.0 6bqp CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BQQA Q96RR4 161 448 588.0 R78:60501 Type1 Active DFGin 6.587 15.248 BLAminus DFGAsp-rot-in -117.25, 175.16 63.58, 81.13 190.18, -6.08 -94.81, 22.39 287.89, 75.14 -58.43, -30.74 out-in out 10.004 Saltbr-in 3.072 HRD-in -71.13, -51.2 74.86, 1.34 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.24, 165.59 APE9-dihe-na 119.03, -163.74 APE8-dihe-in -97.53, 123.98 APE8-rot-in 297.33 APE67-dihe-in -61.07, -18.54 -48.02, -46.96 APE12-dist-in 8.872 APE11-dist-in 11.374 APE10-dist-in 5.454 APE9-dist-in 3.49 None None None XRAY 1.8 0.192 0.228 A 291 269 19 0 0 0 [[165, 446]] 1.0 6bqq CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 6BRCB Q96RR4 161 448 588.0 E5J:60501 Type1 Active DFGin 6.904 15.236 BLAminus DFGAsp-rot-in -120.14, 170.48 63.5, 80.74 196.83, -15.25 -90.91, 25.53 289.59, 77.07 -67.34, -16.81 in-in in 9.907 Saltbr-in 3.435 HRD-in -62.55, -51.64 71.8, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.45, 165.15 APE9-dihe-na 106.61, -160.8 APE8-dihe-in -95.67, 116.32 APE8-rot-in 308.37 APE67-dihe-in -65.13, -23.74 -47.49, -37.58 APE12-dist-in 9.86 APE11-dist-in 11.501 APE10-dist-in 5.568 APE9-dist-in 3.817 None None None XRAY 2.2 0.216 0.265 B 291 260 28 0 0 0 [[165, 446]] 1.0 6brc CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 8TUCA Q96RR4 161 449 588.0 O7I:60501 Type1 Active DFGin 6.731 14.453 BLAminus DFGAsp-rot-in -127.72, 179.53 58.67, 73.65 203.38, -17.06 -84.61, 18.43 283.38, 76.82 -62.91, -24.57 in-in in 9.569 Saltbr-in 2.799 HRD-in -82.06, -44.61 70.49, -2.43 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.56, 162.98 APE9-dihe-na 165.6, 166.4 APE8-dihe-in -75.27, 125.03 APE8-rot-in 300.68 APE67-dihe-in -70.03, -12.9 -55.33, -38.49 APE12-dist-in 13.1 APE11-dist-in 9.505 APE10-dist-in 5.799 APE9-dist-in 3.731 None None None XRAY 1.5 0.169 0.207 A 291 276 13 0 0 0 [[165, 446]] 1.0 8tuc CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 2ZV2A Q96RR4 160 448 588.0 609:60501 Type1 Active DFGin 6.818 14.541 BLAminus DFGAsp-rot-in -122.89, 173.96 59.26, 77.13 191.74, 22.03 -93.92, 23.43 290.42, 66.64 -61.43, -10.01 in-in in 9.337 Saltbr-in 2.615 HRD-in -66.49, -45.72 70.26, -4.68 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.51, 169.38 APE9-dihe-na 107.27, -162.96 APE8-dihe-in -95.28, 121.73 APE8-rot-in 305.12 APE67-dihe-in -59.79, -17.29 -35.35, -59.29 APE12-dist-in 9.52 APE11-dist-in 11.346 APE10-dist-in 5.465 APE9-dist-in 3.687 None None None XRAY 2.4 0.203 0.252 A 298 256 33 0 0 0 [[165, 446]] 1.0 2zv2 CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5YV8A Q96RR4 160 448 588.0 91L:501 Type1 Active DFGin 6.725 14.523 BLAminus DFGAsp-rot-in -122.93, 171.8 61.22, 78.31 196.54, -4.29 -87.86, 25.84 290.89, 69.95 -61.07, -25.0 in-in in 9.359 Saltbr-in 2.745 HRD-in -74.0, -48.27 70.52, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.77, 167.4 APE9-dihe-na 111.03, -156.22 APE8-dihe-in -103.08, 122.32 APE8-rot-in 295.96 APE67-dihe-in -65.57, -15.92 -51.87, -44.0 APE12-dist-in 9.367 APE11-dist-in 11.202 APE10-dist-in 5.356 APE9-dist-in 3.597 None None CAS397 XRAY 1.927 0.166 0.213 A 298 260 29 0 0 0 [[165, 446]] 1.0 5yv8 CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5YVAA Q96RR4 160 448 588.0 91X:501 Type1 Active DFGin 6.736 14.325 BLAminus DFGAsp-rot-in -123.18, 167.02 68.45, 82.08 194.48, 19.14 -95.99, 27.99 293.38, 80.7 -66.32, -18.53 in-in in 9.265 Saltbr-in 2.893 HRD-in -76.51, -45.12 68.31, 6.55 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.47, 165.54 APE9-dihe-na 111.29, -156.09 APE8-dihe-in -98.36, 125.88 APE8-rot-in 309.21 APE67-dihe-in -49.38, -26.44 -46.56, -55.31 APE12-dist-in 9.434 APE11-dist-in 11.298 APE10-dist-in 5.512 APE9-dist-in 3.699 None None CAS397 XRAY 2.574 0.163 0.22 A 298 260 29 0 0 0 [[165, 446]] 1.0 5yva CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5YVBA Q96RR4 160 448 588.0 92C:501 Type1 Active DFGin 6.829 14.446 BLAminus DFGAsp-rot-in -125.28, 169.51 70.11, 86.05 197.09, -10.94 -99.6, 30.35 290.81, 70.43 -69.33, -23.64 in-in in 9.568 Saltbr-in 3.185 HRD-in -71.8, -48.31 70.01, 2.3 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.36, 168.27 APE9-dihe-na 114.71, -158.26 APE8-dihe-in -101.76, 124.26 APE8-rot-in 302.21 APE67-dihe-in -63.45, -17.31 -51.16, -44.24 APE12-dist-in 9.277 APE11-dist-in 11.194 APE10-dist-in 5.355 APE9-dist-in 3.713 None None CAS397 XRAY 2.02 0.172 0.215 A 298 260 29 0 0 0 [[165, 446]] 1.0 5yvb CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5YVCA Q96RR4 160 448 588.0 SU6:501 Type1 Active DFGin 6.79 14.537 BLAminus DFGAsp-rot-in -121.34, 170.34 67.45, 82.63 196.1, -3.87 -94.98, 27.39 288.36, 72.02 -64.36, -27.04 in-in in 9.451 Saltbr-in 3.257 HRD-in -73.56, -49.13 72.24, 1.33 in-in-in SNCiii in-in ActLoopNT-in 2.688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.0, 168.59 APE9-dihe-na 112.92, -160.28 APE8-dihe-in -100.86, 123.38 APE8-rot-in 301.38 APE67-dihe-in -63.99, -14.39 -47.95, -48.2 APE12-dist-in 9.445 APE11-dist-in 11.27 APE10-dist-in 5.445 APE9-dist-in 3.578 None None CAS397 XRAY 2.02 0.172 0.211 A 298 260 29 0 0 0 [[165, 446]] 1.0 5yvc CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CAMKK2 KKCC2_HUMAN 5YV9A Q96RR4 160 448 588.0 91O:501 Type1.5_Back Active DFGin 6.73 14.452 BLAminus DFGAsp-rot-in -123.85, 174.52 61.56, 81.87 198.25, -21.85 -92.24, 22.41 290.07, 70.32 -56.09, -23.41 in-in in 9.661 Saltbr-in 3.221 HRD-in -74.56, -49.39 67.45, 5.32 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.69, 168.21 APE9-dihe-na 108.77, -158.78 APE8-dihe-in -93.76, 126.06 APE8-rot-in 306.2 APE67-dihe-in -60.25, -10.01 -55.44, -47.7 APE12-dist-in 9.441 APE11-dist-in 11.217 APE10-dist-in 5.401 APE9-dist-in 3.592 None None CAS397 XRAY 2.53 0.17 0.222 A 298 260 29 0 0 0 [[165, 446]] 1.0 5yv9 CAMK_CAMKK2_HUMAN CAMK 1.4e-73 253.5 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK CHEK1 CHK1_HUMAN 7AKMA O14757 2 271 476.0 AGS:401 ATPlike Active DFGin 6.775 14.143 BLAminus DFGAsp-rot-in -128.66, 150.55 71.15, 96.3 192.06, -1.98 -103.32, 28.49 292.74, 82.8 -70.74, -21.81 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.28, -45.32 76.75, -0.14 in-in-in SNCiii in-in ActLoopNT-in 3.011 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.43, 171.3 APE9-dihe-na 110.38, -147.97 APE8-dihe-in -135.73, 125.59 APE8-rot-in 300.71 APE67-dihe-in -62.97, -17.75 -56.42, -42.48 APE12-dist-in 9.309 APE11-dist-in 11.674 APE10-dist-in 6.171 APE9-dist-in 3.407 D10R None None XRAY 1.93 0.199 0.242 A 298 270 0 0 0 0 [[9, 265]] 1.0 7akm CAMK_CHEK1_HUMAN CAMK 3.5e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3JVRA O14757 2 272 476.0 AGX:901 Allosteric Active DFGin 6.872 14.177 BLAminus DFGAsp-rot-in -127.98, 150.64 73.31, 94.81 191.65, -17.15 -103.55, 30.03 289.43, 82.54 -69.18, -19.03 in-in in 8.831 Saltbr-in 2.689 HRD-in -74.95, -44.7 78.13, -0.66 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.38, 173.26 APE9-dihe-na 116.8, -150.87 APE8-dihe-in -139.69, 123.15 APE8-rot-in 300.09 APE67-dihe-in -61.84, -23.11 -49.41, -48.15 APE12-dist-in 8.931 APE11-dist-in 11.813 APE10-dist-in 6.298 APE9-dist-in 3.406 None None None XRAY 1.76 0.202 0.225 A 271 258 13 0 0 0 [[9, 265]] 1.0 3jvr CAMK_CHEK1_HUMAN CAMK 2.1e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3F9NA O14757 7 270 476.0 38M:324 Allosteric Active DFGin 6.871 14.306 BLAminus DFGAsp-rot-in -120.26, 153.9 73.21, 93.52 193.52, -1.18 -100.46, 25.66 293.37, 83.17 -66.45, -28.23 in-in in 8.857 Saltbr-in 2.555 HRD-in -79.56, -43.26 73.24, -2.23 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.39, 152.53 APE9-dihe-na 120.62, -163.45 APE8-dihe-in -134.2, 121.67 APE8-rot-in 301.99 APE67-dihe-in -60.59, -25.68 -41.41, -51.19 APE12-dist-in 9.146 APE11-dist-in 11.147 APE10-dist-in 5.801 APE9-dist-in 3.398 None None None XRAY 1.9 0.184 0.216 A 322 253 11 0 0 0 [[9, 265]] 1.0 3f9n CAMK_CHEK1_HUMAN CAMK 3.9e-71 245.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN AF-O14757-K1A O14757 1 273 476.0 No_ligand No_ligand Active DFGin 6.908 13.879 BLAminus DFGAsp-rot-in -126.41, 173.77 59.88, 75.65 197.69, 15.29 -83.37, 18.3 292.07, 88.25 -61.72, -28.43 in-in in 8.997 Saltbr-in 2.756 HRD-in -81.68, -47.56 71.58, -4.39 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.33, 169.83 APE9-dihe-na 111.71, 175.87 APE8-dihe-in -92.2, 123.21 APE8-rot-in 308.56 APE67-dihe-in -63.62, -24.82 -49.79, -44.17 APE12-dist-in 9.178 APE11-dist-in 11.671 APE10-dist-in 6.144 APE9-dist-in 3.634 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[9, 265]] 1.0 AF-O14757-K1 CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN AF-O14757-K3A O14757 1 273 476.0 No_ligand No_ligand Active DFGin 6.65 13.867 BLAminus DFGAsp-rot-in -123.65, -177.83 47.33, 73.45 200.76, 8.72 -76.38, 14.64 294.74, 95.75 -58.94, -31.14 in-in in 8.964 Saltbr-in 2.728 HRD-in -82.53, -48.74 68.72, 4.29 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.6, 168.78 APE9-dihe-na 104.0, 175.5 APE8-dihe-in -88.64, 126.31 APE8-rot-in 306.94 APE67-dihe-in -61.16, -29.27 -52.3, -41.96 APE12-dist-in 9.368 APE11-dist-in 11.541 APE10-dist-in 5.913 APE9-dist-in 3.334 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[9, 265]] 1.0 AF-O14757-K3 CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1IA8A O14757 2 276 476.0 No_ligand No_ligand Active DFGin 6.901 14.276 BLAminus DFGAsp-rot-in -124.2, 154.39 68.94, 96.97 195.01, -18.52 -102.1, 26.7 291.65, 79.3 -65.06, -22.41 in-in in 8.89 Saltbr-in 2.735 HRD-in -75.22, -41.37 69.04, 2.45 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.12, 169.49 APE9-dihe-na 119.83, -148.37 APE8-dihe-in -135.5, 118.95 APE8-rot-in 302.64 APE67-dihe-in -61.39, -22.34 -35.34, -54.92 APE12-dist-in 8.917 APE11-dist-in 11.909 APE10-dist-in 6.335 APE9-dist-in 3.331 None None None XRAY 1.7 0.216 0.235 A 289 272 3 0 0 0 [[9, 265]] 1.0 1ia8 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKMB O14757 2 269 476.0 No_ligand No_ligand Active DFGin 6.729 14.236 BLAminus DFGAsp-rot-in -131.2, 148.86 72.72, 94.14 197.71, -20.23 -102.13, 30.13 293.9, 82.86 -70.24, -23.15 in-in in 8.062 Saltbr-in 2.923 HRD-in -73.93, -45.68 78.44, -0.49 in-in-in SNCiii in-in ActLoopNT-in 3.083 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.14, 171.41 APE9-dihe-na 115.69, -149.76 APE8-dihe-in -139.3, 121.55 APE8-rot-in 304.35 APE67-dihe-in -60.59, -21.72 -51.07, -46.17 APE12-dist-in 9.473 APE11-dist-in 11.679 APE10-dist-in 6.174 APE9-dist-in 3.588 D10R None None XRAY 1.93 0.199 0.242 B 298 268 0 0 0 0 [[9, 265]] 1.0 7akm CAMK_CHEK1_HUMAN CAMK 3.5e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1ZYSA O14757 3 273 476.0 199:400 Type1 Active DFGin 6.822 14.043 BLAminus DFGAsp-rot-in -125.46, 168.25 66.65, 88.29 192.74, -13.5 -97.37, 27.49 292.37, 83.58 -68.83, -18.69 in-in in 9.041 Saltbr-in 2.559 HRD-in -84.01, -42.62 72.63, -1.0 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.0, 171.72 APE9-dihe-na 116.11, -147.59 APE8-dihe-in -140.51, 125.84 APE8-rot-in 300.55 APE67-dihe-in -63.09, -21.21 -45.55, -50.46 APE12-dist-in 8.807 APE11-dist-in 12.021 APE10-dist-in 6.423 APE9-dist-in 3.289 None None None XRAY 1.7 0.227 0.26 A 273 271 0 0 0 0 [[9, 265]] 1.0 1zys CAMK_CHEK1_HUMAN CAMK 4.9e-71 245.0 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2E9VA O14757 2 269 476.0 85A:1001 Type1 Active DFGin 6.975 14.637 BLAminus DFGAsp-rot-in -131.54, 177.83 55.26, 98.09 202.18, -36.85 -109.61, 30.41 286.66, 68.67 -62.59, -29.32 in-in in 8.701 Saltbr-in 2.67 HRD-in -76.45, -37.92 59.71, 14.92 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 168.23 APE9-dihe-na 122.1, -169.86 APE8-dihe-in -111.29, 110.84 APE8-rot-in 305.57 APE67-dihe-in -47.02, -35.65 -25.69, -68.51 APE12-dist-in 9.434 APE11-dist-in 11.908 APE10-dist-in 6.143 APE9-dist-in 3.595 None None None XRAY 2.0 0.279 0.333 A 268 268 0 0 0 0 [[9, 265]] 1.0 2e9v CAMK_CHEK1_HUMAN CAMK 2e-71 246.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2E9VB O14757 2 269 476.0 85A:2001 Type1 Active DFGin 6.918 14.189 BLAminus DFGAsp-rot-in -126.14, 170.02 63.09, 96.2 201.59, -31.88 -109.54, 31.48 299.02, 75.08 -66.55, -19.9 in-in in 8.259 Saltbr-in 2.694 HRD-in -68.57, -49.41 72.45, 8.8 in-in-in SNCiii in-in ActLoopNT-in 3.096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 165.61 APE9-dihe-na 116.5, -156.5 APE8-dihe-in -122.27, 105.18 APE8-rot-in 303.15 APE67-dihe-in -59.07, -28.34 -21.14, -51.59 APE12-dist-in 9.033 APE11-dist-in 11.859 APE10-dist-in 6.153 APE9-dist-in 3.462 None None None XRAY 2.0 0.279 0.333 B 268 268 0 0 0 0 [[9, 265]] 1.0 2e9v CAMK_CHEK1_HUMAN CAMK 2e-71 246.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2E9OA O14757 2 270 476.0 A58:1001 Type1 Active DFGin 6.931 14.179 BLAminus DFGAsp-rot-in -128.32, 168.44 64.14, 94.25 191.57, -13.89 -103.44, 34.01 291.92, 79.18 -71.63, -19.2 in-in in 8.896 Saltbr-in 2.777 HRD-in -74.31, -47.15 72.74, 4.43 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.26, 171.72 APE9-dihe-na 111.42, -153.4 APE8-dihe-in -133.8, 111.32 APE8-rot-in 302.29 APE67-dihe-in -62.45, -26.48 -26.55, -51.1 APE12-dist-in 9.089 APE11-dist-in 11.704 APE10-dist-in 6.009 APE9-dist-in 3.225 None None None XRAY 2.1 0.229 0.259 A 269 269 0 0 0 0 [[9, 265]] 1.0 2e9o CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2E9UA O14757 2 270 476.0 A25:1001 Type1 Active DFGin 7.011 14.113 BLAminus DFGAsp-rot-in -132.04, 172.65 62.85, 89.38 203.07, -16.4 -101.09, 30.5 293.08, 81.27 -73.07, -16.47 in-in in 8.634 Saltbr-in 2.594 HRD-in -70.01, -43.61 71.24, 2.07 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.27, 170.1 APE9-dihe-na 118.87, -157.35 APE8-dihe-in -129.87, 116.69 APE8-rot-in 299.78 APE67-dihe-in -60.89, -25.73 -32.98, -51.09 APE12-dist-in 9.224 APE11-dist-in 11.666 APE10-dist-in 5.958 APE9-dist-in 3.289 None None None XRAY 2.0 0.242 0.277 A 269 269 0 0 0 0 [[9, 265]] 1.0 2e9u CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2GHGA O14757 2 270 476.0 A53:1 Type1 Active DFGin 6.886 14.53 BLAminus DFGAsp-rot-in -166.32, 170.51 70.16, 71.94 180.63, 7.8 -87.0, 41.41 289.83, 76.15 -75.14, -46.9 in-in in 8.977 Saltbr-in 3.136 HRD-in -93.04, -17.87 49.7, 7.2 in-in-in SNCiii in-in ActLoopNT-in 3.17 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.48, 116.46 APE9-dihe-na -170.15, -133.06 APE8-dihe-in -140.13, 110.94 APE8-rot-in 291.04 APE67-dihe-in -68.96, -50.13 -35.06, -49.54 APE12-dist-in 8.896 APE11-dist-in 11.861 APE10-dist-in 6.332 APE9-dist-in 3.697 None None None XRAY 3.5 0.24 0.314 A 269 269 0 0 0 0 [[9, 265]] 1.0 2ghg CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YWPA O14757 2 270 476.0 A42:1 Type1 Active DFGin 6.846 14.194 BLAminus DFGAsp-rot-in -128.34, 170.16 65.69, 87.88 192.79, -4.07 -101.03, 37.84 293.97, 84.7 -68.74, -18.33 in-in in 8.773 Saltbr-in 2.586 HRD-in -63.32, -40.53 66.09, 3.77 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.27, 147.17 APE9-dihe-na 141.47, -143.91 APE8-dihe-in -127.52, 116.49 APE8-rot-in 286.38 APE67-dihe-in -56.51, -33.62 -29.01, -64.65 APE12-dist-in 9.177 APE11-dist-in 11.697 APE10-dist-in 6.129 APE9-dist-in 3.396 None None None XRAY 2.9 0.242 0.297 A 269 269 0 0 0 0 [[9, 265]] 1.0 2ywp CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3OT3A O14757 4 272 476.0 22K:1 Type1 Active DFGin 7.072 14.088 BLAminus DFGAsp-rot-in -119.38, 162.39 68.19, 101.86 210.91, -61.58 -107.35, 22.12 289.5, 79.69 -65.92, -24.4 in-in in 8.404 Saltbr-in 2.644 HRD-in -72.88, -42.96 74.77, -4.22 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.04, 168.72 APE9-dihe-na 114.72, -154.18 APE8-dihe-in -135.81, 120.72 APE8-rot-in 300.78 APE67-dihe-in -62.65, -21.04 -40.11, -52.91 APE12-dist-in 9.089 APE11-dist-in 11.425 APE10-dist-in 6.232 APE9-dist-in 3.377 None None None XRAY 1.44 0.185 0.202 A 273 261 8 0 0 0 [[9, 265]] 1.0 3ot3 CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3OT8A O14757 4 272 476.0 MI5:1 Type1 Active DFGin 7.0 14.027 BLAminus DFGAsp-rot-in -120.24, 163.62 66.2, 100.88 210.67, -61.41 -107.87, 26.52 289.17, 80.05 -67.79, -28.22 in-in in 8.382 Saltbr-in 2.676 HRD-in -76.11, -44.26 74.22, -4.28 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.29, 156.87 APE9-dihe-na 115.01, -158.59 APE8-dihe-in -135.82, 120.71 APE8-rot-in 300.89 APE67-dihe-in -59.91, -23.22 -36.95, -56.24 APE12-dist-in 9.322 APE11-dist-in 11.252 APE10-dist-in 5.879 APE9-dist-in 3.304 None None None XRAY 1.645 0.179 0.202 A 273 255 14 0 0 0 [[9, 265]] 1.0 3ot8 CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3U9NA O14757 7 272 476.0 09H:301 Type1 Active DFGin 6.902 14.222 BLAminus DFGAsp-rot-in -129.35, 168.34 66.97, 89.35 195.19, -14.23 -103.09, 30.47 290.62, 76.37 -69.94, -19.85 in-in in 8.941 Saltbr-in 2.98 HRD-in -75.25, -47.19 74.3, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.97, 166.31 APE9-dihe-na 118.13, -152.42 APE8-dihe-in -130.48, 118.2 APE8-rot-in 302.9 APE67-dihe-in -59.94, -25.46 -32.53, -57.85 APE12-dist-in 8.944 APE11-dist-in 11.526 APE10-dist-in 6.123 APE9-dist-in 3.378 None None None XRAY 1.85 0.197 0.229 A 273 258 8 0 0 0 [[9, 265]] 1.0 3u9n CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2X8EA O14757 9 270 476.0 X8E:1271 Type1 Active DFGin 6.973 14.28 BLAminus DFGAsp-rot-in -124.04, 146.44 71.63, 110.62 205.27, -26.94 -118.45, 20.59 294.1, 101.48 -77.34, -5.52 in-in in 8.746 Saltbr-in 2.746 HRD-in -57.57, -35.91 68.86, -17.53 in-in-in SNCiii in-in ActLoopNT-in 3.18 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 160.7 APE9-dihe-na 116.57, -159.67 APE8-dihe-in -130.77, 130.86 APE8-rot-in 326.48 APE67-dihe-in -78.63, -14.78 -51.23, -40.57 APE12-dist-in 9.614 APE11-dist-in 11.717 APE10-dist-in 5.962 APE9-dist-in 3.777 None None None XRAY 2.5 0.235 0.309 A 276 259 3 0 0 0 [[9, 265]] 1.0 2x8e CAMK_CHEK1_HUMAN CAMK 2.3e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YERA O14757 2 269 476.0 TQ1:1270 Type1 Active DFGin 6.756 14.258 BLAminus DFGAsp-rot-in -124.59, 145.71 75.35, 98.7 200.74, -30.89 -104.18, 25.73 293.91, 82.78 -62.89, -29.92 in-in in 8.96 Saltbr-in 2.625 HRD-in -76.13, -45.9 72.42, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.32, 169.84 APE9-dihe-na 113.06, -165.98 APE8-dihe-in -114.1, 119.87 APE8-rot-in 298.55 APE67-dihe-in -61.8, -19.78 -47.68, -48.11 APE12-dist-in 8.584 APE11-dist-in 11.797 APE10-dist-in 6.106 APE9-dist-in 3.296 None None None XRAY 1.83 0.147 0.175 A 276 268 0 0 0 0 [[9, 265]] 1.0 2yer CAMK_CHEK1_HUMAN CAMK 2.3e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YEXA O14757 2 270 476.0 YEX:1278 Type1 Active DFGin 6.893 14.384 BLAminus DFGAsp-rot-in -127.36, 145.61 77.89, 95.73 200.51, -34.33 -100.45, 22.36 290.83, 83.74 -60.39, -34.45 in-in in 8.981 Saltbr-in 2.687 HRD-in -75.84, -47.88 76.45, 1.35 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.42, 168.54 APE9-dihe-na 112.0, -176.49 APE8-dihe-in -102.85, 121.8 APE8-rot-in 300.84 APE67-dihe-in -62.59, -19.14 -49.95, -47.33 APE12-dist-in 8.615 APE11-dist-in 11.848 APE10-dist-in 6.118 APE9-dist-in 3.454 None None None XRAY 1.3 0.135 0.164 A 276 269 0 0 0 0 [[9, 265]] 1.0 2yex CAMK_CHEK1_HUMAN CAMK 2.3e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSNA O14757 3 280 476.0 A58:301 Type1 Active DFGin 6.932 14.164 BLAminus DFGAsp-rot-in -128.61, 164.88 70.43, 97.56 190.92, -11.64 -103.2, 24.55 286.11, 81.86 -65.53, -27.87 in-in in 8.797 Saltbr-in 2.69 HRD-in -73.22, -47.77 74.33, -1.49 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.34, 169.78 APE9-dihe-na 114.52, -151.5 APE8-dihe-in -131.96, 119.56 APE8-rot-in 303.59 APE67-dihe-in -63.31, -19.83 -39.51, -51.75 APE12-dist-in 9.012 APE11-dist-in 11.629 APE10-dist-in 6.158 APE9-dist-in 3.27 None None None XRAY 2.1 0.178 0.217 A 278 270 8 0 0 0 [[9, 265]] 1.0 4fsn CAMK_CHEK1_HUMAN CAMK 2.3e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSMA O14757 3 280 476.0 HK1:301 Type1 Active DFGin 6.811 14.1 BLAminus DFGAsp-rot-in -131.51, 171.53 65.39, 98.27 193.34, 1.16 -106.32, 22.69 289.25, 89.34 -66.85, -29.11 in-in in 8.607 Saltbr-in 2.93 HRD-in -70.99, -49.26 75.29, 1.6 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.1, 168.74 APE9-dihe-na 117.28, -151.19 APE8-dihe-in -134.15, 119.96 APE8-rot-in 302.46 APE67-dihe-in -60.14, -26.02 -38.68, -52.02 APE12-dist-in 9.051 APE11-dist-in 11.522 APE10-dist-in 5.959 APE9-dist-in 3.286 None None None XRAY 2.3 0.176 0.198 A 279 265 13 0 0 0 [[9, 265]] 1.0 4fsm CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSRA O14757 3 280 476.0 HKC:300 Type1 Active DFGin 6.871 14.281 BLAminus DFGAsp-rot-in -126.58, 165.61 71.14, 98.24 210.94, -29.48 -108.12, 23.67 292.66, 86.79 -61.1, -36.33 in-in in 9.154 Saltbr-in 2.844 HRD-in -68.1, -45.01 72.09, -2.18 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 148.18 APE9-dihe-na 118.31, -163.42 APE8-dihe-in -128.11, 114.92 APE8-rot-in 300.87 APE67-dihe-in -63.19, -17.37 -35.33, -51.8 APE12-dist-in 9.392 APE11-dist-in 11.198 APE10-dist-in 5.734 APE9-dist-in 3.337 None None None XRAY 2.5 0.177 0.198 A 279 269 9 0 0 0 [[9, 265]] 1.0 4fsr CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSWA O14757 3 280 476.0 HK6:301 Type1 Active DFGin 6.961 14.348 BLAminus DFGAsp-rot-in -119.62, 151.67 67.77, 103.9 188.9, -5.46 -105.99, 26.03 287.76, 84.88 -67.76, -25.89 in-in in 8.512 Saltbr-in 2.831 HRD-in -69.73, -47.61 75.54, -0.76 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.8, 151.78 APE9-dihe-na 118.73, -158.26 APE8-dihe-in -133.6, 120.62 APE8-rot-in 303.14 APE67-dihe-in -61.67, -21.76 -43.39, -49.14 APE12-dist-in 9.169 APE11-dist-in 11.129 APE10-dist-in 5.487 APE9-dist-in 3.328 None None CSO168 XRAY 2.3 0.185 0.212 A 279 266 12 0 0 0 [[9, 265]] 1.0 4fsw CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSYA O14757 3 280 476.0 HK7:301 Type1 Active DFGin 7.037 14.406 BLAminus DFGAsp-rot-in -133.9, 170.9 64.36, 92.44 198.77, -8.59 -102.37, 28.4 289.81, 84.88 -65.52, -30.66 in-in in 8.364 Saltbr-in 2.762 HRD-in -71.27, -49.45 77.31, 1.06 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.87, 166.71 APE9-dihe-na 112.85, -162.09 APE8-dihe-in -124.8, 131.06 APE8-rot-in 295.23 APE67-dihe-in -64.56, -25.01 -56.53, -41.12 APE12-dist-in 9.077 APE11-dist-in 11.423 APE10-dist-in 6.021 APE9-dist-in 3.356 None None CSO57 XRAY 2.3 0.183 0.226 A 279 268 10 0 0 0 [[9, 265]] 1.0 4fsy CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSZA O14757 3 280 476.0 HK8:301 Type1 Active DFGin 6.949 14.39 BLAminus DFGAsp-rot-in -119.9, 153.43 66.34, 106.24 192.58, -8.17 -107.62, 26.47 288.2, 87.05 -66.44, -34.56 in-in in 8.491 Saltbr-in 2.745 HRD-in -69.86, -48.51 74.46, 2.01 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.3, 158.49 APE9-dihe-na 111.96, -155.49 APE8-dihe-in -132.22, 121.7 APE8-rot-in 308.64 APE67-dihe-in -64.81, -18.9 -40.6, -48.6 APE12-dist-in 9.243 APE11-dist-in 11.267 APE10-dist-in 5.605 APE9-dist-in 3.287 None None CSO57,CSO168 XRAY 2.3 0.175 0.22 A 279 270 8 0 0 0 [[9, 265]] 1.0 4fsz CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FT0A O14757 3 280 476.0 HK9:301 Type1 Active DFGin 6.834 14.434 BLAminus DFGAsp-rot-in -121.3, 156.17 66.51, 99.62 186.92, 8.83 -103.86, 23.38 286.77, 86.68 -67.74, -22.21 in-in in 8.618 Saltbr-in 2.753 HRD-in -71.32, -48.66 76.71, -5.7 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.21, 169.55 APE9-dihe-na 114.98, -146.91 APE8-dihe-in -133.85, 119.36 APE8-rot-in 306.38 APE67-dihe-in -61.82, -22.76 -40.65, -49.73 APE12-dist-in 8.984 APE11-dist-in 11.585 APE10-dist-in 5.992 APE9-dist-in 3.394 None None None XRAY 2.3 0.174 0.203 A 279 266 8 0 0 0 [[9, 265]] 1.0 4ft0 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FT3A O14757 2 280 476.0 H1K:301 Type1 Active DFGin 6.964 14.165 BLAminus DFGAsp-rot-in -125.83, 166.69 67.61, 100.05 196.98, -7.73 -109.27, 28.0 288.45, 82.38 -68.34, -27.81 in-in in 8.589 Saltbr-in 2.771 HRD-in -69.78, -44.73 71.85, -0.6 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.81, 154.64 APE9-dihe-na 118.96, -155.02 APE8-dihe-in -132.3, 119.16 APE8-rot-in 307.95 APE67-dihe-in -63.69, -19.94 -39.85, -50.54 APE12-dist-in 9.145 APE11-dist-in 11.182 APE10-dist-in 5.755 APE9-dist-in 3.373 None None CSO168,CSO215 XRAY 2.5 0.17 0.213 A 279 272 7 0 0 0 [[9, 265]] 1.0 4ft3 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FT5A O14757 3 280 476.0 H2K:300 Type1 Active DFGin 6.953 14.266 BLAminus DFGAsp-rot-in -127.2, 165.87 68.8, 94.55 205.88, -17.28 -104.24, 26.6 287.26, 85.38 -67.4, -28.05 in-in in 8.449 Saltbr-in 2.762 HRD-in -69.57, -47.79 77.92, -5.64 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.4, 157.75 APE9-dihe-na 110.01, -155.34 APE8-dihe-in -130.07, 123.38 APE8-rot-in 305.79 APE67-dihe-in -63.14, -20.95 -44.51, -49.54 APE12-dist-in 9.238 APE11-dist-in 11.505 APE10-dist-in 5.805 APE9-dist-in 3.423 None None None XRAY 2.4 0.18 0.223 A 279 265 13 0 0 0 [[9, 265]] 1.0 4ft5 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FT7A O14757 3 280 476.0 H3K:301 Type1 Active DFGin 6.917 14.254 BLAminus DFGAsp-rot-in -123.26, 155.01 65.6, 104.61 193.68, -24.03 -106.93, 24.92 287.72, 82.64 -63.39, -27.36 in-in in 8.745 Saltbr-in 2.773 HRD-in -68.13, -44.52 71.13, 4.67 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.74, 167.5 APE9-dihe-na 117.49, -151.06 APE8-dihe-in -131.37, 120.33 APE8-rot-in 307.45 APE67-dihe-in -64.01, -19.31 -40.36, -50.09 APE12-dist-in 9.056 APE11-dist-in 11.569 APE10-dist-in 6.056 APE9-dist-in 3.295 None None None XRAY 2.2 0.172 0.195 A 279 270 8 0 0 0 [[9, 265]] 1.0 4ft7 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FT9A O14757 2 280 476.0 H4K:300 Type1 Active DFGin 7.007 14.251 BLAminus DFGAsp-rot-in -126.66, 162.85 64.17, 98.66 200.36, -22.25 -102.76, 25.95 287.5, 82.94 -63.78, -29.14 in-in in 8.707 Saltbr-in 2.683 HRD-in -70.59, -46.02 71.89, 2.79 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.14, 167.54 APE9-dihe-na 119.1, -145.69 APE8-dihe-in -134.13, 123.1 APE8-rot-in 304.24 APE67-dihe-in -62.3, -22.11 -43.6, -50.05 APE12-dist-in 8.945 APE11-dist-in 11.72 APE10-dist-in 6.162 APE9-dist-in 3.283 None None None XRAY 2.2 0.163 0.206 A 279 270 9 0 0 0 [[9, 265]] 1.0 4ft9 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTAA O14757 3 280 476.0 H5K:301 Type1 Active DFGin 7.033 14.229 BLAminus DFGAsp-rot-in -115.22, 157.1 65.07, 98.74 192.97, -14.03 -104.16, 26.55 287.97, 87.34 -67.17, -28.17 in-in in 8.609 Saltbr-in 2.74 HRD-in -69.34, -47.6 75.8, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.7, 154.16 APE9-dihe-na 113.98, -159.29 APE8-dihe-in -129.33, 114.8 APE8-rot-in 303.04 APE67-dihe-in -62.29, -17.92 -34.19, -52.76 APE12-dist-in 9.19 APE11-dist-in 11.217 APE10-dist-in 5.669 APE9-dist-in 3.272 None None CSO168 XRAY 2.4 0.172 0.211 A 279 265 13 0 0 0 [[9, 265]] 1.0 4fta CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTCA O14757 2 280 476.0 H6K:301 Type1 Active DFGin 7.007 14.217 BLAminus DFGAsp-rot-in -124.04, 161.25 66.03, 97.49 196.21, -16.94 -103.03, 25.51 288.01, 85.12 -63.04, -32.4 in-in in 8.584 Saltbr-in 2.753 HRD-in -73.06, -46.23 73.2, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.76, 151.76 APE9-dihe-na 120.55, -155.44 APE8-dihe-in -134.19, 118.99 APE8-rot-in 305.56 APE67-dihe-in -65.13, -17.34 -40.64, -50.7 APE12-dist-in 9.196 APE11-dist-in 11.308 APE10-dist-in 5.709 APE9-dist-in 3.312 None None CSO168 XRAY 2.0 0.17 0.194 A 279 267 12 0 0 0 [[9, 265]] 1.0 4ftc CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTIA O14757 3 279 476.0 H7K:301 Type1 Active DFGin 6.938 14.265 BLAminus DFGAsp-rot-in -131.71, 165.12 68.45, 90.85 196.43, -4.42 -99.85, 27.35 288.14, 85.15 -66.83, -26.06 in-in in 8.757 Saltbr-in 2.669 HRD-in -69.83, -48.6 74.25, 0.8 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.15, 166.8 APE9-dihe-na 118.02, -149.51 APE8-dihe-in -134.76, 120.08 APE8-rot-in 303.98 APE67-dihe-in -63.85, -21.57 -41.85, -47.71 APE12-dist-in 8.948 APE11-dist-in 11.514 APE10-dist-in 6.1 APE9-dist-in 3.37 None None None XRAY 2.2 0.175 0.194 A 279 270 7 0 0 0 [[9, 265]] 1.0 4fti CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTJA O14757 3 279 476.0 H8K:301 Type1 Active DFGin 6.858 14.158 BLAminus DFGAsp-rot-in -126.08, 172.19 64.35, 93.91 197.61, -2.22 -103.12, 23.88 288.19, 87.63 -63.51, -29.53 in-in in 8.607 Saltbr-in 2.739 HRD-in -70.61, -46.43 71.78, 1.15 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.56, 169.93 APE9-dihe-na 115.22, -147.36 APE8-dihe-in -135.06, 117.23 APE8-rot-in 306.8 APE67-dihe-in -63.27, -20.35 -37.52, -49.27 APE12-dist-in 9.024 APE11-dist-in 11.658 APE10-dist-in 6.163 APE9-dist-in 3.437 None None None XRAY 2.2 0.182 0.205 A 279 266 11 0 0 0 [[9, 265]] 1.0 4ftj CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTOA O14757 3 271 476.0 3HK:301 Type1 Active DFGin 6.959 14.238 BLAminus DFGAsp-rot-in -127.57, 164.38 64.01, 101.47 201.87, -25.44 -105.82, 25.9 289.5, 84.0 -68.68, -24.99 in-in in 8.734 Saltbr-in 2.783 HRD-in -68.98, -46.7 71.08, 0.02 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.6 APE9-dihe-na 111.8, -161.39 APE8-dihe-in -129.05, 120.57 APE8-rot-in 307.69 APE67-dihe-in -63.78, -20.08 -41.73, -50.26 APE12-dist-in 9.252 APE11-dist-in 11.186 APE10-dist-in 5.713 APE9-dist-in 3.299 None None None XRAY 2.1 0.181 0.195 A 279 252 17 0 0 0 [[9, 265]] 1.0 4fto CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTQA O14757 3 270 476.0 4HK:301 Type1 Active DFGin 6.948 14.167 BLAminus DFGAsp-rot-in -121.37, 155.84 67.1, 99.27 191.76, -16.35 -103.93, 23.74 289.44, 84.22 -64.63, -29.39 in-in in 8.644 Saltbr-in 2.729 HRD-in -73.53, -44.86 70.84, 1.85 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 150.17 APE9-dihe-na 119.72, -160.49 APE8-dihe-in -131.7, 116.38 APE8-rot-in 301.57 APE67-dihe-in -62.8, -20.14 -38.44, -50.62 APE12-dist-in 9.157 APE11-dist-in 11.155 APE10-dist-in 5.573 APE9-dist-in 3.312 None None CSO168 XRAY 2.0 0.186 0.22 A 279 255 13 0 0 0 [[9, 265]] 1.0 4ftq CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTRA O14757 3 271 476.0 5HK:301 Type1 Active DFGin 6.943 14.278 BLAminus DFGAsp-rot-in -123.21, 153.43 70.58, 95.78 190.83, 0.19 -100.72, 25.84 289.71, 85.74 -70.61, -24.38 in-in in 8.442 Saltbr-in 2.79 HRD-in -69.02, -49.81 76.72, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 153.77 APE9-dihe-na 114.4, -160.46 APE8-dihe-in -130.66, 117.37 APE8-rot-in 305.19 APE67-dihe-in -61.47, -21.96 -37.98, -50.68 APE12-dist-in 9.214 APE11-dist-in 11.239 APE10-dist-in 5.761 APE9-dist-in 3.341 None None None XRAY 2.25 0.174 0.214 A 279 258 11 0 0 0 [[9, 265]] 1.0 4ftr CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTTA O14757 3 280 476.0 6HK:301 Type1 Active DFGin 6.94 14.218 BLAminus DFGAsp-rot-in -122.83, 153.42 68.27, 105.19 193.76, 2.03 -108.24, 23.4 287.92, 83.92 -66.27, -24.53 in-in in 8.543 Saltbr-in 2.745 HRD-in -71.13, -47.05 73.89, 3.88 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.81, 170.65 APE9-dihe-na 115.8, -149.58 APE8-dihe-in -133.84, 119.22 APE8-rot-in 302.97 APE67-dihe-in -62.62, -20.85 -38.98, -49.57 APE12-dist-in 9.301 APE11-dist-in 11.764 APE10-dist-in 6.151 APE9-dist-in 3.3 None None None XRAY 2.3 0.173 0.215 A 279 266 12 0 0 0 [[9, 265]] 1.0 4ftt CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTUA O14757 3 280 476.0 7HK:301 Type1 Active DFGin 7.004 14.209 BLAminus DFGAsp-rot-in -122.0, 154.39 66.73, 96.53 192.26, -11.28 -100.93, 26.02 289.18, 80.78 -66.13, -27.5 in-in in 8.572 Saltbr-in 2.735 HRD-in -67.38, -44.96 72.12, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.18, 152.58 APE9-dihe-na 115.82, -158.26 APE8-dihe-in -130.91, 118.67 APE8-rot-in 304.9 APE67-dihe-in -60.79, -23.34 -39.91, -50.93 APE12-dist-in 9.326 APE11-dist-in 11.31 APE10-dist-in 5.899 APE9-dist-in 3.324 None None None XRAY 2.1 0.191 0.21 A 279 270 8 0 0 0 [[9, 265]] 1.0 4ftu CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4GH2A O14757 3 280 476.0 HK0:301 Type1 Active DFGin 7.051 14.226 BLAminus DFGAsp-rot-in -123.38, 153.93 69.02, 96.41 194.77, -13.7 -100.38, 23.56 288.59, 84.72 -64.85, -27.37 in-in in 8.309 Saltbr-in 2.895 HRD-in -70.31, -46.53 72.01, 0.52 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.99, 152.09 APE9-dihe-na 116.77, -155.33 APE8-dihe-in -133.62, 120.42 APE8-rot-in 304.79 APE67-dihe-in -64.36, -18.36 -40.72, -49.54 APE12-dist-in 9.236 APE11-dist-in 11.437 APE10-dist-in 5.983 APE9-dist-in 3.279 None None CSO168,CSO215 XRAY 2.03 0.165 0.192 A 279 268 10 0 0 0 [[9, 265]] 1.0 4gh2 CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1NVQA O14757 3 273 476.0 UCN:400 Type1 Active DFGin 7.103 14.396 BLAminus DFGAsp-rot-in -125.86, 163.9 66.03, 91.68 191.58, -7.13 -101.2, 28.08 286.61, 74.15 -67.93, -18.15 in-in in 8.517 Saltbr-in 2.873 HRD-in -72.89, -40.79 69.72, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.67, 158.23 APE9-dihe-na 121.41, -157.73 APE8-dihe-in -131.99, 117.0 APE8-rot-in 305.5 APE67-dihe-in -60.55, -25.67 -32.5, -52.91 APE12-dist-in 9.297 APE11-dist-in 11.514 APE10-dist-in 5.747 APE9-dist-in 3.379 None None None XRAY 2.0 0.206 0.234 A 289 264 7 0 0 0 [[9, 265]] 1.0 1nvq CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1NVRA O14757 3 273 476.0 STU:400 Type1 Active DFGin 7.007 14.466 BLAminus DFGAsp-rot-in -138.12, 170.91 63.58, 88.44 194.71, -15.4 -97.82, 26.51 284.37, 82.9 -65.94, -21.37 in-in in 8.834 Saltbr-in 3.325 HRD-in -77.73, -42.26 72.42, 0.07 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 168.99 APE9-dihe-na 123.47, -148.6 APE8-dihe-in -135.84, 118.76 APE8-rot-in 301.9 APE67-dihe-in -60.54, -22.99 -38.52, -52.15 APE12-dist-in 8.986 APE11-dist-in 11.773 APE10-dist-in 6.22 APE9-dist-in 3.344 None None None XRAY 1.8 0.193 0.226 A 289 264 7 0 0 0 [[9, 265]] 1.0 1nvr CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1NVSA O14757 3 273 476.0 UCM:400 Type1 Active DFGin 6.948 14.327 BLAminus DFGAsp-rot-in -124.54, 157.02 67.79, 99.69 200.82, -33.61 -105.15, 29.66 290.94, 77.78 -68.62, -19.97 in-in in 8.855 Saltbr-in 2.994 HRD-in -72.71, -44.77 71.02, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.31, 168.53 APE9-dihe-na 121.14, -147.06 APE8-dihe-in -136.26, 119.24 APE8-rot-in 304.24 APE67-dihe-in -59.99, -25.66 -37.19, -52.23 APE12-dist-in 9.001 APE11-dist-in 11.829 APE10-dist-in 6.273 APE9-dist-in 3.311 None None None XRAY 1.8 0.232 0.255 A 289 264 7 0 0 0 [[9, 265]] 1.0 1nvs CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMQA O14757 7 269 476.0 ZYQ:1270 Type1 Active DFGin 6.796 14.301 BLAminus DFGAsp-rot-in -129.03, 145.77 85.94, 84.92 199.1, 5.73 -97.17, 15.57 294.92, 82.28 -58.59, -22.48 in-in in 8.846 Saltbr-in 2.95 HRD-in -73.66, -48.07 79.85, -4.75 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.83, 146.62 APE9-dihe-na 120.81, -140.09 APE8-dihe-in -140.39, 114.38 APE8-rot-in 303.0 APE67-dihe-in -66.52, -23.18 -38.86, -48.73 APE12-dist-in 9.438 APE11-dist-in 11.69 APE10-dist-in 6.292 APE9-dist-in 3.682 None None None XRAY 2.48 0.222 0.25 A 289 246 17 0 0 0 [[9, 265]] 1.0 2wmq CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMRA O14757 7 270 476.0 ZYR:1271 Type1 Active DFGin 6.788 14.246 BLAminus DFGAsp-rot-in -123.65, 155.63 63.04, 103.09 197.46, -23.82 -106.02, 13.15 292.74, 86.07 -58.1, -20.3 in-in in 8.801 Saltbr-in 3.087 HRD-in -72.49, -46.78 75.8, -4.43 in-in-in SNCiii in-in ActLoopNT-in 3.033 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.91, 174.03 APE9-dihe-na 103.24, -160.08 APE8-dihe-in -132.56, 126.77 APE8-rot-in 295.16 APE67-dihe-in -69.57, -25.74 -49.21, -44.24 APE12-dist-in 9.393 APE11-dist-in 11.479 APE10-dist-in 5.803 APE9-dist-in 3.312 None None None XRAY 2.43 0.211 0.26 A 289 254 10 0 0 0 [[9, 265]] 1.0 2wmr CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMSA O14757 7 270 476.0 ZYS:1271 Type1 Active DFGin 6.833 14.097 BLAminus DFGAsp-rot-in -120.52, 146.54 79.14, 90.95 190.65, -5.09 -98.33, 31.19 298.09, 80.64 -65.06, -38.38 in-in in 8.545 Saltbr-in 3.215 HRD-in -69.44, -50.22 83.54, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.01, 158.54 APE9-dihe-na 117.42, -150.3 APE8-dihe-in -138.73, 119.72 APE8-rot-in 292.61 APE67-dihe-in -66.29, -34.03 -39.39, -47.99 APE12-dist-in 9.422 APE11-dist-in 11.326 APE10-dist-in 5.674 APE9-dist-in 3.574 None None None XRAY 2.7 0.225 0.259 A 289 243 21 0 0 0 [[9, 265]] 1.0 2wms CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMTA O14757 8 270 476.0 ZYT:1271 Type1 Active DFGin 6.785 14.281 BLAminus DFGAsp-rot-in -125.63, 146.24 75.37, 98.66 191.87, -9.57 -104.06, 17.98 297.2, 81.75 -49.27, -35.19 in-in in 8.635 Saltbr-in 3.235 HRD-in -66.09, -46.05 77.82, -7.26 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.87, 162.85 APE9-dihe-na 85.87, -159.47 APE8-dihe-in -114.07, 140.35 APE8-rot-in 306.26 APE67-dihe-in -62.65, -35.9 -60.11, -40.99 APE12-dist-in 9.654 APE11-dist-in 11.321 APE10-dist-in 6.292 APE9-dist-in 3.348 None None None XRAY 2.55 0.216 0.257 A 289 248 15 0 0 0 [[9, 265]] 1.0 2wmt CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMUA O14757 9 270 476.0 ZYU:1271 Type1 Active DFGin 6.761 14.225 BLAminus DFGAsp-rot-in -124.58, 149.67 73.48, 98.24 198.27, -8.84 -107.24, 22.24 291.36, 85.36 -63.37, -31.63 in-in in 8.708 Saltbr-in 3.267 HRD-in -66.01, -47.65 80.18, -8.04 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.94, 156.42 APE9-dihe-na 115.63, -158.82 APE8-dihe-in -128.41, 142.86 APE8-rot-in 304.02 APE67-dihe-in -62.86, -36.77 -61.36, -43.1 APE12-dist-in 9.56 APE11-dist-in 11.344 APE10-dist-in 5.724 APE9-dist-in 3.622 None None None XRAY 2.6 0.232 0.261 A 289 246 16 0 0 0 [[9, 265]] 1.0 2wmu CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMVA O14757 7 270 476.0 ZYV:1271 Type1 Active DFGin 6.82 14.229 BLAminus DFGAsp-rot-in -124.93, 150.62 73.24, 97.26 193.01, -14.37 -104.78, 26.94 292.36, 84.42 -64.24, -27.28 in-in in 8.594 Saltbr-in 2.992 HRD-in -67.11, -46.21 78.67, -3.53 in-in-in SNCiii in-in ActLoopNT-in 3.098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.54, 147.19 APE9-dihe-na 131.68, -159.35 APE8-dihe-in -132.74, 118.07 APE8-rot-in 302.64 APE67-dihe-in -64.16, -20.61 -42.4, -49.2 APE12-dist-in 9.241 APE11-dist-in 11.599 APE10-dist-in 6.167 APE9-dist-in 3.648 None None None XRAY 2.009 0.215 0.241 A 289 251 13 0 0 0 [[9, 265]] 1.0 2wmv CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMWA O14757 7 269 476.0 ZYW:1270 Type1 Active DFGin 6.909 14.423 BLAminus DFGAsp-rot-in -138.43, 150.75 76.46, 89.37 187.63, -11.69 -98.01, 21.58 291.28, 80.82 -54.99, -32.89 in-in in 8.443 Saltbr-in 2.967 HRD-in -68.78, -46.97 76.52, -3.86 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.16, 158.72 APE9-dihe-na 118.12, -156.78 APE8-dihe-in -132.71, 131.43 APE8-rot-in 292.41 APE67-dihe-in -67.92, -22.67 -51.42, -45.51 APE12-dist-in 9.365 APE11-dist-in 11.322 APE10-dist-in 5.785 APE9-dist-in 3.46 None None None XRAY 2.43 0.23 0.25 A 289 247 16 0 0 0 [[9, 265]] 1.0 2wmw CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2WMXA O14757 7 269 476.0 ZY6:1270 Type1 Active DFGin 6.909 14.421 BLAminus DFGAsp-rot-in -138.41, 150.78 76.37, 89.37 187.65, -11.72 -97.97, 21.58 291.28, 80.83 -54.97, -32.94 in-in in 8.441 Saltbr-in 2.966 HRD-in -68.74, -47.03 76.58, -3.91 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.46, 168.26 APE9-dihe-na 106.57, -155.31 APE8-dihe-in -139.79, 119.56 APE8-rot-in 301.17 APE67-dihe-in -67.05, -27.81 -41.76, -47.11 APE12-dist-in 9.425 APE11-dist-in 11.466 APE10-dist-in 5.846 APE9-dist-in 3.437 None None None XRAY 2.45 0.22 0.244 A 289 248 15 0 0 0 [[9, 265]] 1.0 2wmx CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2X8DA O14757 2 281 476.0 X8D:1282 Type1 Active DFGin 6.877 14.222 BLAminus DFGAsp-rot-in -125.34, 145.96 75.16, 98.27 197.08, -28.3 -103.12, 27.2 290.54, 84.91 -65.81, -25.94 in-in in 8.844 Saltbr-in 2.735 HRD-in -72.7, -49.53 78.44, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.58, 168.95 APE9-dihe-na 117.28, -146.64 APE8-dihe-in -140.7, 121.77 APE8-rot-in 299.91 APE67-dihe-in -64.55, -22.3 -47.16, -49.22 APE12-dist-in 8.928 APE11-dist-in 11.939 APE10-dist-in 6.34 APE9-dist-in 3.35 None None None XRAY 1.9 0.162 0.192 A 289 280 0 0 0 0 [[9, 265]] 1.0 2x8d CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2X8IA O14757 2 269 476.0 X8I:1270 Type1 Active DFGin 6.776 14.083 BLAminus DFGAsp-rot-in -130.04, 149.82 73.34, 96.28 195.54, -17.19 -103.39, 27.63 292.92, 82.96 -65.75, -24.88 in-in in 8.793 Saltbr-in 2.576 HRD-in -77.47, -44.34 72.43, -2.94 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.06, -13.81 APE9-dihe-na -73.16, 171.96 APE8-dihe-in -80.79, 122.28 APE8-rot-in 306.49 APE67-dihe-in -61.85, -17.2 -49.93, -44.93 APE12-dist-in 8.562 APE11-dist-in 11.543 APE10-dist-in 5.779 APE9-dist-in 3.699 None None None XRAY 1.92 0.189 0.224 A 289 261 7 0 0 0 [[9, 265]] 1.0 2x8i CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2XEYA O14757 6 269 476.0 YVQ:1270 Type1 Active DFGin 6.804 14.351 BLAminus DFGAsp-rot-in -120.46, 134.88 92.9, 102.51 200.89, -29.09 -108.36, 19.57 294.43, 85.01 -58.71, -37.33 in-in in 8.628 Saltbr-in 2.76 HRD-in -66.52, -46.0 79.92, -6.26 in-in-in SNCiii in-in ActLoopNT-in 3.069 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.81, 159.95 APE9-dihe-na 131.23, -158.32 APE8-dihe-in -120.65, 138.4 APE8-rot-in 296.68 APE67-dihe-in -63.86, -44.09 -60.1, -42.19 APE12-dist-in 9.709 APE11-dist-in 11.471 APE10-dist-in 5.99 APE9-dist-in 3.662 None None None XRAY 2.7 0.222 0.266 A 289 252 12 0 0 0 [[9, 265]] 1.0 2xey CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2XEZA O14757 7 270 476.0 XEZ:1271 Type1 Active DFGin 6.917 14.25 BLAminus DFGAsp-rot-in -133.54, 142.66 88.28, 99.32 191.48, -0.12 -106.34, 26.02 290.91, 85.99 -64.69, -27.13 in-in in 8.597 Saltbr-in 3.054 HRD-in -65.08, -46.22 76.5, -0.68 in-in-in SNCiii in-in ActLoopNT-in 3.013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.97, 168.01 APE9-dihe-na 96.0, -161.59 APE8-dihe-in -119.9, 136.16 APE8-rot-in 305.18 APE67-dihe-in -63.7, -42.45 -59.06, -41.87 APE12-dist-in 9.071 APE11-dist-in 11.462 APE10-dist-in 6.133 APE9-dist-in 3.519 None None None XRAY 2.25 0.211 0.237 A 289 249 15 0 0 0 [[9, 265]] 1.0 2xez CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2XF0A O14757 4 270 476.0 4UB:1271 Type1 Active DFGin 6.962 14.334 BLAminus DFGAsp-rot-in -127.76, 149.31 66.74, 102.17 199.04, -19.68 -107.04, 28.33 293.33, 77.96 -65.23, -24.59 in-in in 8.573 Saltbr-in 2.894 HRD-in -65.87, -48.49 79.64, -2.44 in-in-in SNCiii in-in ActLoopNT-in 3.089 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.69, -175.12 APE9-dihe-na 97.78, -156.38 APE8-dihe-in -122.87, 129.03 APE8-rot-in 303.15 APE67-dihe-in -54.36, -33.92 -44.93, -56.27 APE12-dist-in 9.385 APE11-dist-in 11.503 APE10-dist-in 6.16 APE9-dist-in 3.449 None None None XRAY 2.4 0.204 0.244 A 289 251 16 0 0 0 [[9, 265]] 1.0 2xf0 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YDIA O14757 2 281 476.0 YDI:1282 Type1 Active DFGin 6.976 13.97 BLAminus DFGAsp-rot-in -126.3, 150.36 77.21, 97.59 191.28, -20.15 -103.07, 23.89 288.63, 85.13 -67.84, -26.49 in-in in 8.786 Saltbr-in 2.768 HRD-in -77.6, -45.08 76.82, -1.13 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.57, 169.22 APE9-dihe-na 113.97, -148.03 APE8-dihe-in -138.83, 121.25 APE8-rot-in 303.94 APE67-dihe-in -62.29, -21.07 -47.63, -48.12 APE12-dist-in 8.918 APE11-dist-in 12.019 APE10-dist-in 6.433 APE9-dist-in 3.354 None None None XRAY 1.6 0.168 0.2 A 289 280 0 0 0 0 [[9, 265]] 1.0 2ydi CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YM3A O14757 8 270 476.0 YM3:1271 Type1 Active DFGin 6.945 14.55 BLAminus DFGAsp-rot-in -124.53, 145.82 77.8, 96.14 198.83, -27.85 -106.02, 30.03 290.55, 85.33 -72.09, -23.02 in-in in 8.634 Saltbr-in 2.756 HRD-in -74.61, -45.33 76.04, 0.41 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.51, 177.11 APE9-dihe-na 108.64, -151.07 APE8-dihe-in -133.43, 124.53 APE8-rot-in 300.4 APE67-dihe-in -62.52, -16.87 -44.07, -52.65 APE12-dist-in 9.576 APE11-dist-in 11.772 APE10-dist-in 6.288 APE9-dist-in 3.279 None None None XRAY 2.007 0.179 0.203 A 289 247 16 0 0 0 [[9, 265]] 1.0 2ym3 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YM4A O14757 4 270 476.0 4YM:1271 Type1 Active DFGin 6.943 14.899 BLAminus DFGAsp-rot-in -122.13, 155.72 68.31, 93.18 193.17, -24.24 -103.18, 30.94 289.55, 80.73 -72.79, -19.76 in-in in 8.664 Saltbr-in 3.501 HRD-in -69.97, -47.22 81.59, -11.8 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.93, 148.67 APE9-dihe-na 118.08, -148.67 APE8-dihe-in -131.7, 127.55 APE8-rot-in 303.59 APE67-dihe-in -61.62, -16.06 -47.52, -50.41 APE12-dist-in 9.702 APE11-dist-in 11.482 APE10-dist-in 5.987 APE9-dist-in 3.547 None None None XRAY 2.35 0.206 0.247 A 289 251 16 0 0 0 [[9, 265]] 1.0 2ym4 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YM8A O14757 8 270 476.0 YM8:1271 Type1 Active DFGin 6.918 14.484 BLAminus DFGAsp-rot-in -119.81, 160.75 69.41, 92.68 215.14, -34.75 -106.25, 26.79 288.47, 85.52 -68.01, -21.81 in-in in 8.463 Saltbr-in 2.642 HRD-in -74.85, -49.07 83.35, -9.52 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.5, 170.9 APE9-dihe-na 117.99, -150.41 APE8-dihe-in -140.36, 119.04 APE8-rot-in 303.38 APE67-dihe-in -63.4, -22.13 -41.5, -51.94 APE12-dist-in 9.391 APE11-dist-in 11.695 APE10-dist-in 6.202 APE9-dist-in 3.459 None None None XRAY 2.07 0.191 0.231 A 289 246 17 0 0 0 [[9, 265]] 1.0 2ym8 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4HYHA O14757 4 272 476.0 1AM:301 Type1 Active DFGin 6.906 14.218 BLAminus DFGAsp-rot-in -128.98, 166.78 69.3, 88.21 188.7, -1.01 -100.12, 24.75 289.06, 83.24 -68.3, -20.44 in-in in 9.041 Saltbr-in 2.497 HRD-in -78.56, -45.08 75.8, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.65, 153.88 APE9-dihe-na 129.07, -156.46 APE8-dihe-in -132.58, 121.58 APE8-rot-in 303.73 APE67-dihe-in -60.58, -22.44 -37.91, -54.78 APE12-dist-in 9.063 APE11-dist-in 11.335 APE10-dist-in 5.834 APE9-dist-in 3.455 None None None XRAY 1.7 0.204 0.226 A 289 263 6 0 0 0 [[9, 265]] 1.0 4hyh CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4HYIA O14757 3 274 476.0 1AO:304 Type1 Active DFGin 6.971 14.263 BLAminus DFGAsp-rot-in -133.52, 170.26 67.21, 89.03 191.42, -8.45 -100.55, 26.73 288.63, 81.95 -69.01, -20.83 in-in in 8.703 Saltbr-in 2.8 HRD-in -76.04, -45.38 76.0, -0.31 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.36, 169.96 APE9-dihe-na 118.31, -154.09 APE8-dihe-in -134.47, 119.9 APE8-rot-in 301.58 APE67-dihe-in -63.47, -20.04 -40.17, -52.51 APE12-dist-in 8.794 APE11-dist-in 11.802 APE10-dist-in 6.333 APE9-dist-in 3.478 None None None XRAY 1.399 0.183 0.202 A 289 269 3 0 0 0 [[9, 265]] 1.0 4hyi CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 1ZLTA O14757 2 276 476.0 HYM:400 Type1 Active DFGin 6.614 13.867 BLAminus DFGAsp-rot-in -126.38, 168.93 65.17, 92.12 199.97, -26.51 -102.75, 29.34 295.7, 86.46 -65.38, -26.93 in-in in 8.567 Saltbr-in 3.001 HRD-in -74.75, -46.48 73.58, -1.97 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.22, 155.91 APE9-dihe-na 115.18, -153.21 APE8-dihe-in -135.77, 120.73 APE8-rot-in 302.12 APE67-dihe-in -61.41, -27.81 -37.92, -49.99 APE12-dist-in 9.026 APE11-dist-in 11.822 APE10-dist-in 6.386 APE9-dist-in 3.233 None None None XRAY 1.74 0.227 0.265 A 295 272 3 0 0 0 [[9, 265]] 1.0 1zlt CAMK_CHEK1_HUMAN CAMK 2.9e-71 245.8 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2GDOA O14757 1 273 476.0 12C:298 Type1 Active DFGin 6.959 13.949 BLAminus DFGAsp-rot-in -127.91, 159.13 71.31, 115.52 209.79, -17.44 -129.98, 13.98 288.91, 76.03 -55.88, -6.97 in-in in 8.642 Saltbr-in 2.586 HRD-in -77.91, -46.29 78.14, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.47, 167.51 APE9-dihe-na 121.4, -118.02 APE8-dihe-in -163.54, 121.61 APE8-rot-in 299.5 APE67-dihe-in -61.0, -21.04 -40.53, -57.04 APE12-dist-in 9.394 APE11-dist-in 12.077 APE10-dist-in 6.613 APE9-dist-in 3.333 None None None XRAY 3.0 0.206 0.259 A 295 269 4 0 0 0 [[9, 265]] 1.0 2gdo CAMK_CHEK1_HUMAN CAMK 2.9e-71 245.8 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BR1A O14757 2 276 476.0 PFP:1277 Type1 Active DFGin 6.793 14.123 BLAminus DFGAsp-rot-in -130.59, 159.96 73.94, 93.36 194.21, -12.31 -102.22, 21.99 289.33, 86.45 -62.48, -28.03 in-in in 8.999 Saltbr-in 2.892 HRD-in -73.11, -44.22 70.56, 4.17 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.65, 173.48 APE9-dihe-na 118.03, -148.27 APE8-dihe-in -138.18, 120.92 APE8-rot-in 298.16 APE67-dihe-in -63.38, -22.4 -48.9, -47.72 APE12-dist-in 9.018 APE11-dist-in 11.717 APE10-dist-in 6.306 APE9-dist-in 3.471 None None None XRAY 2.0 0.163 0.226 A 297 272 3 0 0 0 [[9, 265]] 1.0 2br1 CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BRBA O14757 2 276 476.0 PFQ:1277 Type1 Active DFGin 6.777 14.206 BLAminus DFGAsp-rot-in -124.91, 167.19 62.16, 91.6 199.39, 0.03 -103.57, 28.61 293.18, 87.6 -71.38, -21.49 in-in in 8.788 Saltbr-in 3.085 HRD-in -74.34, -47.68 74.97, -0.21 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.17, 171.97 APE9-dihe-na 115.21, -150.83 APE8-dihe-in -129.85, 123.76 APE8-rot-in 305.36 APE67-dihe-in -64.1, -22.07 -43.43, -50.05 APE12-dist-in 9.134 APE11-dist-in 11.642 APE10-dist-in 6.016 APE9-dist-in 3.293 None None None XRAY 2.1 0.243 0.272 A 297 272 3 0 0 0 [[9, 265]] 1.0 2brb CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BRGA O14757 7 269 476.0 DFY:1270 Type1 Active DFGin 6.757 14.35 BLAminus DFGAsp-rot-in -136.08, 139.9 86.09, 98.75 197.85, -6.91 -105.44, 16.17 289.83, 90.07 -62.74, -23.98 in-in in 8.947 Saltbr-in 2.723 HRD-in -77.38, -46.1 73.52, -1.4 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.14, 173.86 APE9-dihe-na 118.8, -153.5 APE8-dihe-in -126.63, 115.38 APE8-rot-in 292.75 APE67-dihe-in -63.0, -12.21 -42.58, -47.41 APE12-dist-in 9.002 APE11-dist-in 11.592 APE10-dist-in 6.309 APE9-dist-in 3.574 None None None XRAY 2.1 0.212 0.294 A 297 257 6 0 0 0 [[9, 265]] 1.0 2brg CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BRHA O14757 6 271 476.0 DFW:1272 Type1 Active DFGin 6.959 14.661 BLAminus DFGAsp-rot-in -140.73, 143.43 79.42, 92.98 197.92, -11.71 -97.12, 17.45 288.86, 83.71 -48.34, -29.94 in-in in 9.146 Saltbr-in 2.704 HRD-in -78.41, -40.27 70.76, 3.5 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.83, 172.27 APE9-dihe-na 128.03, -148.83 APE8-dihe-in -135.7, 117.05 APE8-rot-in 297.03 APE67-dihe-in -64.11, -20.87 -41.67, -50.92 APE12-dist-in 9.609 APE11-dist-in 11.51 APE10-dist-in 6.147 APE9-dist-in 3.48 None None None XRAY 2.1 0.183 0.257 A 297 257 9 0 0 0 [[9, 265]] 1.0 2brh CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BRMA O14757 7 274 476.0 DFZ:1275 Type1 Active DFGin 6.84 14.038 BLAminus DFGAsp-rot-in -135.86, 168.58 63.75, 91.55 195.13, -9.27 -106.09, 29.22 295.16, 87.09 -76.07, -17.33 in-in in 8.848 Saltbr-in 2.709 HRD-in -72.25, -46.84 78.63, -1.49 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.66, 173.98 APE9-dihe-na 111.72, -142.65 APE8-dihe-in -137.48, 130.31 APE8-rot-in 300.44 APE67-dihe-in -56.88, -34.55 -54.89, -47.74 APE12-dist-in 9.027 APE11-dist-in 11.79 APE10-dist-in 6.3 APE9-dist-in 3.432 None None None XRAY 2.2 0.228 0.281 A 297 263 5 0 0 0 [[9, 265]] 1.0 2brm CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BRNA O14757 6 276 476.0 DF1:1277 Type1 Active DFGin 6.912 14.137 BLAminus DFGAsp-rot-in -116.25, 147.52 75.05, 98.47 214.13, -55.23 -108.38, 27.03 293.17, 87.0 -64.45, -36.89 in-in in 8.657 Saltbr-in 2.943 HRD-in -68.02, -45.32 74.19, 6.58 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.95, 164.76 APE9-dihe-na 125.6, -149.2 APE8-dihe-in -128.12, 132.65 APE8-rot-in 303.29 APE67-dihe-in -63.75, -28.46 -56.16, -47.84 APE12-dist-in 9.268 APE11-dist-in 11.654 APE10-dist-in 6.198 APE9-dist-in 3.462 None None None XRAY 2.8 0.207 0.285 A 297 268 3 0 0 0 [[9, 265]] 1.0 2brn CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2BROA O14757 2 276 476.0 DF2:1277 Type1 Active DFGin 6.757 14.064 BLAminus DFGAsp-rot-in -133.35, 154.27 78.19, 90.51 194.87, -0.09 -99.21, 21.9 296.19, 85.72 -64.77, -25.64 in-in in 8.908 Saltbr-in 2.81 HRD-in -70.81, -47.49 77.16, 3.76 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.25, 173.9 APE9-dihe-na 116.88, -150.3 APE8-dihe-in -136.74, 118.66 APE8-rot-in 294.36 APE67-dihe-in -57.57, -22.87 -44.25, -49.17 APE12-dist-in 9.937 APE11-dist-in 11.741 APE10-dist-in 6.267 APE9-dist-in 3.477 None None None XRAY 2.2 0.202 0.279 A 297 272 3 0 0 0 [[9, 265]] 1.0 2bro CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2C3JA O14757 6 270 476.0 DBQ:1271 Type1 Active DFGin 6.95 14.213 BLAminus DFGAsp-rot-in -126.74, 163.69 80.23, 87.53 193.96, -14.87 -90.31, 22.21 294.83, 82.32 -58.14, -33.43 in-in in 8.796 Saltbr-in 2.899 HRD-in -73.1, -48.96 76.11, 1.81 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.88, 175.78 APE9-dihe-na 109.29, -146.39 APE8-dihe-in -139.98, 118.77 APE8-rot-in 292.58 APE67-dihe-in -63.48, -24.39 -42.88, -48.22 APE12-dist-in 9.223 APE11-dist-in 11.743 APE10-dist-in 6.236 APE9-dist-in 3.31 None None None XRAY 2.1 0.186 0.262 A 297 257 8 0 0 0 [[9, 265]] 1.0 2c3j CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2C3LA O14757 2 273 476.0 IDZ:1274 Type1 Active DFGin 6.887 14.166 BLAminus DFGAsp-rot-in -131.41, 151.16 78.39, 98.04 186.25, 0.36 -102.86, 15.22 294.33, 84.15 -49.16, -41.07 in-in in 9.023 Saltbr-in 2.703 HRD-in -80.86, -41.66 77.27, -9.64 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.08, -171.58 APE9-dihe-na 93.96, -140.63 APE8-dihe-in -146.55, 106.89 APE8-rot-in 296.71 APE67-dihe-in -64.44, -18.7 -36.5, -53.88 APE12-dist-in 9.208 APE11-dist-in 11.512 APE10-dist-in 6.019 APE9-dist-in 3.39 None None None XRAY 2.35 0.189 0.279 A 297 265 7 0 0 0 [[9, 265]] 1.0 2c3l CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2CGUA O14757 6 271 476.0 3A3:1272 Type1 Active DFGin 6.823 14.1 BLAminus DFGAsp-rot-in -124.71, 156.71 64.48, 90.01 184.36, 2.32 -96.89, 19.31 292.44, 88.74 -51.64, -28.97 in-in in 8.769 Saltbr-in 2.383 HRD-in -74.29, -41.42 79.85, -2.68 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.8, 178.02 APE9-dihe-na 97.6, -145.39 APE8-dihe-in -133.7, 117.92 APE8-rot-in 294.82 APE67-dihe-in -64.83, -17.81 -46.02, -48.32 APE12-dist-in 9.237 APE11-dist-in 11.48 APE10-dist-in 6.15 APE9-dist-in 3.6 None None None XRAY 2.5 0.185 0.271 A 297 263 3 0 0 0 [[9, 265]] 1.0 2cgu CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2CGVA O14757 6 272 476.0 3B3:1273 Type1 Active DFGin 6.844 14.213 BLAminus DFGAsp-rot-in -129.68, 147.96 68.93, 97.35 190.15, -8.78 -101.57, 19.74 288.82, 96.28 -56.31, -31.16 in-in in 8.847 Saltbr-in 2.428 HRD-in -68.97, -54.08 89.53, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.1, -178.57 APE9-dihe-na 98.55, -155.28 APE8-dihe-in -129.75, 111.18 APE8-rot-in 282.3 APE67-dihe-in -64.98, -23.42 -32.4, -55.02 APE12-dist-in 9.536 APE11-dist-in 11.593 APE10-dist-in 6.218 APE9-dist-in 3.444 None None None XRAY 2.6 0.183 0.256 A 297 264 3 0 0 0 [[9, 265]] 1.0 2cgv CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2CGWA O14757 6 271 476.0 3C3:1272 Type1 Active DFGin 6.888 14.132 BLAminus DFGAsp-rot-in -126.31, 150.55 70.28, 91.55 194.05, -6.71 -95.72, 25.62 291.49, 82.98 -65.61, -26.92 in-in in 8.914 Saltbr-in 2.721 HRD-in -72.1, -42.26 69.41, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.62, 178.07 APE9-dihe-na 112.61, -143.97 APE8-dihe-in -142.62, 117.73 APE8-rot-in 285.52 APE67-dihe-in -65.12, -19.5 -40.76, -49.59 APE12-dist-in 9.127 APE11-dist-in 11.614 APE10-dist-in 6.212 APE9-dist-in 3.397 None None None XRAY 2.2 0.189 0.249 A 297 262 4 0 0 0 [[9, 265]] 1.0 2cgw CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2CGXA O14757 6 273 476.0 3D3:1274 Type1 Active DFGin 6.833 14.117 BLAminus DFGAsp-rot-in -125.86, 152.33 68.83, 92.31 190.41, -2.89 -96.49, 22.24 295.74, 81.77 -68.33, -25.83 in-in in 8.865 Saltbr-in 2.506 HRD-in -77.3, -42.87 73.93, 3.29 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.75, 179.04 APE9-dihe-na 103.61, -149.01 APE8-dihe-in -138.5, 119.55 APE8-rot-in 290.31 APE67-dihe-in -60.17, -27.97 -48.57, -47.19 APE12-dist-in 9.296 APE11-dist-in 11.659 APE10-dist-in 6.192 APE9-dist-in 3.328 None None None XRAY 2.2 0.191 0.258 A 297 265 3 0 0 0 [[9, 265]] 1.0 2cgx CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3NLBA O14757 6 271 476.0 5BE:298 Type1 Active DFGin 6.824 14.2 BLAminus DFGAsp-rot-in -124.55, 157.38 77.01, 93.93 198.52, -18.44 -101.53, 21.95 294.88, 88.17 -62.88, -34.66 in-in in 8.794 Saltbr-in 2.506 HRD-in -79.47, -46.53 76.26, -3.28 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.04, 155.47 APE9-dihe-na 120.15, -160.26 APE8-dihe-in -135.73, 120.95 APE8-rot-in 291.21 APE67-dihe-in -56.59, -27.5 -50.08, -48.2 APE12-dist-in 9.465 APE11-dist-in 11.54 APE10-dist-in 5.744 APE9-dist-in 3.245 None None None XRAY 1.9 0.184 0.241 A 297 261 5 0 0 0 [[9, 265]] 1.0 3nlb CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5DLSA O14757 6 270 476.0 5CV:301 Type1 Active DFGin 6.776 14.407 BLAminus DFGAsp-rot-in -127.94, 160.56 79.78, 85.12 189.98, -12.1 -96.72, 25.68 290.3, 82.54 -70.34, -28.9 in-in in 9.245 Saltbr-in 2.667 HRD-in -77.0, -45.98 73.56, 2.81 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.09, 158.49 APE9-dihe-na 127.57, -153.37 APE8-dihe-in -134.23, 121.92 APE8-rot-in 301.31 APE67-dihe-in -59.78, -21.49 -55.94, -43.97 APE12-dist-in 9.434 APE11-dist-in 11.581 APE10-dist-in 5.722 APE9-dist-in 3.526 None None None XRAY 2.15 0.168 0.222 A 297 257 8 0 0 0 [[9, 265]] 1.0 5dls CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BKNA O14757 7 271 476.0 ADE:301 Type1 Active DFGin 6.715 13.789 BLAminus DFGAsp-rot-in -123.22, 178.11 54.82, 98.09 193.79, -41.05 -102.01, 23.12 288.04, 98.46 -58.72, -44.48 in-in in 8.457 Saltbr-in 2.721 HRD-in -80.97, -48.58 70.41, 11.52 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.16, 155.63 APE9-dihe-na 150.16, -148.64 APE8-dihe-in -128.29, 117.27 APE8-rot-in 312.17 APE67-dihe-in -60.96, -21.14 -43.64, -55.99 APE12-dist-in 9.397 APE11-dist-in 11.474 APE10-dist-in 6.03 APE9-dist-in 3.709 None None None XRAY 2.74 0.212 0.28 A 297 259 6 0 0 0 [[9, 265]] 1.0 7bkn CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BKOA O14757 7 271 476.0 TVW:301 Type1 Active DFGin 7.547 14.686 BLAminus DFGAsp-rot-in -131.7, 142.84 75.6, 98.75 183.84, 15.18 -102.17, 27.33 285.76, 86.92 -59.85, -38.14 in-in in 9.01 Saltbr-in 2.719 HRD-in -80.43, -45.24 72.06, 16.06 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.56, 177.47 APE9-dihe-na 109.29, -153.33 APE8-dihe-in -121.47, 124.07 APE8-rot-in 300.96 APE67-dihe-in -54.02, -14.59 -49.3, -62.95 APE12-dist-in 9.072 APE11-dist-in 11.553 APE10-dist-in 6.291 APE9-dist-in 3.27 None None None XRAY 2.3 0.246 0.331 A 297 259 6 0 0 0 [[9, 265]] 1.0 7bko CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYEA O14757 3 280 476.0 3DL:301 Type1 Active DFGin 6.914 14.112 BLAminus DFGAsp-rot-in -124.84, 156.69 77.9, 93.39 192.75, -14.3 -103.1, 23.38 290.26, 80.26 -63.73, -29.53 in-in in 8.942 Saltbr-in 2.583 HRD-in -72.42, -47.96 79.14, 0.2 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.29, 174.85 APE9-dihe-na 114.12, -149.57 APE8-dihe-in -137.26, 119.94 APE8-rot-in 299.74 APE67-dihe-in -63.28, -19.9 -43.96, -48.93 APE12-dist-in 9.079 APE11-dist-in 11.708 APE10-dist-in 6.181 APE9-dist-in 3.258 None None None XRAY 2.05 0.171 0.208 A 298 271 7 0 0 0 [[9, 265]] 1.0 4qye CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYFA O14757 3 280 476.0 3DV:301 Type1 Active DFGin 6.897 14.063 BLAminus DFGAsp-rot-in -128.79, 158.9 75.16, 93.31 190.83, -11.41 -103.23, 30.89 290.8, 79.05 -72.58, -24.18 in-in in 8.932 Saltbr-in 2.669 HRD-in -71.38, -49.09 76.48, 2.12 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.94, 176.72 APE9-dihe-na 105.68, -144.7 APE8-dihe-in -142.3, 123.67 APE8-rot-in 303.25 APE67-dihe-in -64.92, -19.69 -49.83, -45.85 APE12-dist-in 8.988 APE11-dist-in 11.703 APE10-dist-in 6.2 APE9-dist-in 3.269 None None None XRAY 2.15 0.171 0.223 A 298 269 7 0 0 0 [[9, 265]] 1.0 4qyf CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYGA O14757 3 273 476.0 3DW:301 Type1 Active DFGin 6.729 14.232 BLAminus DFGAsp-rot-in -130.14, 167.67 66.49, 85.89 193.68, -10.18 -96.57, 24.99 292.46, 83.53 -66.91, -20.27 in-in in 8.613 Saltbr-in 2.684 HRD-in -75.2, -47.38 77.56, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 169.22 APE9-dihe-na 118.09, -146.73 APE8-dihe-in -136.23, 118.9 APE8-rot-in 301.78 APE67-dihe-in -58.65, -24.95 -43.65, -51.64 APE12-dist-in 8.923 APE11-dist-in 11.779 APE10-dist-in 6.226 APE9-dist-in 3.41 None None None XRAY 1.75 0.185 0.214 A 298 264 7 0 0 0 [[9, 265]] 1.0 4qyg CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYGB O14757 3 273 476.0 3DW:301 Type1 Active DFGin 6.814 14.26 BLAminus DFGAsp-rot-in -131.28, 167.96 67.6, 84.41 192.31, -11.66 -94.04, 25.62 290.63, 84.63 -68.09, -18.4 in-in in 8.643 Saltbr-in 2.815 HRD-in -74.82, -46.02 77.08, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.14, 172.0 APE9-dihe-na 119.92, -148.59 APE8-dihe-in -135.99, 119.53 APE8-rot-in 301.26 APE67-dihe-in -57.64, -21.53 -47.69, -50.26 APE12-dist-in 9.249 APE11-dist-in 11.721 APE10-dist-in 6.149 APE9-dist-in 3.456 None None None XRAY 1.75 0.185 0.214 B 298 264 7 0 0 0 [[9, 265]] 1.0 4qyg CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYHA O14757 3 273 476.0 3DX:301 Type1 Active DFGin 6.714 13.841 BLAminus DFGAsp-rot-in -127.62, 167.13 70.22, 81.93 195.71, -9.45 -93.79, 22.64 293.4, 81.54 -68.79, -21.86 in-in in 8.418 Saltbr-in 3.126 HRD-in -75.71, -43.97 72.44, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.3, 173.48 APE9-dihe-na 109.75, -150.14 APE8-dihe-in -135.16, 119.63 APE8-rot-in 304.63 APE67-dihe-in -60.05, -24.72 -49.2, -45.16 APE12-dist-in 9.03 APE11-dist-in 11.673 APE10-dist-in 6.112 APE9-dist-in 3.398 None None None XRAY 1.9 0.199 0.235 A 298 264 7 0 0 0 [[9, 265]] 1.0 4qyh CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4QYHB O14757 3 273 476.0 3DX:301 Type1 Active DFGin 6.879 14.009 BLAminus DFGAsp-rot-in -124.39, 169.48 67.51, 85.49 195.83, -7.37 -93.96, 24.74 292.25, 85.07 -64.1, -25.79 in-in in 8.511 Saltbr-in 2.792 HRD-in -72.54, -45.81 74.0, 2.82 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.18, 171.25 APE9-dihe-na 115.52, -148.64 APE8-dihe-in -137.75, 119.64 APE8-rot-in 296.85 APE67-dihe-in -60.78, -22.11 -45.63, -50.5 APE12-dist-in 9.125 APE11-dist-in 11.766 APE10-dist-in 6.176 APE9-dist-in 3.458 None None None XRAY 1.9 0.199 0.235 B 298 264 7 0 0 0 [[9, 265]] 1.0 4qyh CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4RVKA O14757 3 273 476.0 3XK:301 Type1 Active DFGin 6.786 14.085 BLAminus DFGAsp-rot-in -129.79, 164.19 71.3, 92.68 197.46, -16.37 -106.21, 24.95 283.48, 87.3 -69.95, -19.64 in-in in 8.496 Saltbr-in 2.583 HRD-in -71.05, -45.75 75.91, 1.09 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.98, 171.98 APE9-dihe-na 109.08, -154.55 APE8-dihe-in -133.03, 121.44 APE8-rot-in 305.51 APE67-dihe-in -59.83, -19.94 -43.49, -53.85 APE12-dist-in 9.058 APE11-dist-in 11.837 APE10-dist-in 6.179 APE9-dist-in 3.177 None None None XRAY 1.85 0.26 0.299 A 298 264 7 0 0 0 [[9, 265]] 1.0 4rvk CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4RVLA O14757 3 273 476.0 3XL:301 Type1 Active DFGin 6.89 14.115 BLAminus DFGAsp-rot-in -127.93, 163.2 71.68, 92.52 195.21, -15.74 -100.89, 24.56 288.93, 80.66 -66.04, -26.13 in-in in 8.546 Saltbr-in 2.691 HRD-in -73.58, -46.56 74.64, 2.34 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.27, 175.0 APE9-dihe-na 109.81, -150.01 APE8-dihe-in -139.94, 120.27 APE8-rot-in 300.49 APE67-dihe-in -61.11, -23.55 -46.48, -50.16 APE12-dist-in 9.112 APE11-dist-in 11.806 APE10-dist-in 6.191 APE9-dist-in 3.225 None None None XRAY 1.85 0.19 0.216 A 298 258 13 0 0 0 [[9, 265]] 1.0 4rvl CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4RVMA O14757 3 273 476.0 3X7:301 Type1 Active DFGin 6.862 14.038 BLAminus DFGAsp-rot-in -123.09, 161.86 72.52, 87.28 197.85, -15.25 -98.9, 25.75 290.38, 81.52 -65.59, -25.28 in-in in 8.499 Saltbr-in 2.659 HRD-in -75.9, -43.39 74.19, 2.07 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.76, 173.82 APE9-dihe-na 114.14, -153.45 APE8-dihe-in -138.11, 123.56 APE8-rot-in 300.31 APE67-dihe-in -62.25, -23.64 -48.14, -48.07 APE12-dist-in 9.028 APE11-dist-in 11.724 APE10-dist-in 6.066 APE9-dist-in 3.304 None None None XRAY 1.86 0.203 0.242 A 298 264 7 0 0 0 [[9, 265]] 1.0 4rvm CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOA O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.258 14.346 BLAminus DFGAsp-rot-in -129.99, 164.38 63.12, 90.57 193.78, -16.25 -95.99, 30.1 286.66, 77.28 -66.31, -26.96 in-in in 8.834 Saltbr-in 2.687 HRD-in -79.3, -45.9 76.54, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 172.04 APE9-dihe-na 107.34, -156.22 APE8-dihe-in -136.58, 123.75 APE8-rot-in 305.71 APE67-dihe-in -59.04, -20.83 -49.6, -50.22 APE12-dist-in 8.951 APE11-dist-in 11.921 APE10-dist-in 6.385 APE9-dist-in 3.572 D10R None None XRAY 1.8 0.192 0.235 A 300 270 0 0 0 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.5e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7AKOB O14757 2 271 476.0 STU:60301 Type1 Active DFGin 7.037 14.527 BLAminus DFGAsp-rot-in -133.06, 166.86 60.65, 91.44 190.55, -7.87 -101.1, 26.21 287.91, 78.35 -62.72, -24.94 in-in in 9.183 Saltbr-in 3.404 HRD-in -77.35, -44.25 76.09, 6.63 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.79, 168.24 APE9-dihe-na 123.14, -149.89 APE8-dihe-in -132.89, 126.1 APE8-rot-in 304.27 APE67-dihe-in -62.82, -10.87 -52.63, -48.98 APE12-dist-in 8.63 APE11-dist-in 11.884 APE10-dist-in 6.247 APE9-dist-in 3.495 D10R None None XRAY 1.8 0.192 0.235 B 300 270 0 0 0 0 [[9, 265]] 1.0 7ako CAMK_CHEK1_HUMAN CAMK 3.5e-71 245.5 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2HOGA O14757 2 280 476.0 710:324 Type1 Active DFGin 6.918 14.348 BLAminus DFGAsp-rot-in -132.2, 167.83 69.16, 94.58 193.81, -13.12 -104.9, 28.28 291.65, 77.59 -68.3, -20.83 in-in in 8.924 Saltbr-in 2.865 HRD-in -73.55, -46.39 73.44, 0.35 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.82, 159.6 APE9-dihe-na 116.01, -154.6 APE8-dihe-in -136.97, 116.06 APE8-rot-in 302.9 APE67-dihe-in -59.7, -25.14 -31.53, -54.03 APE12-dist-in 9.189 APE11-dist-in 11.437 APE10-dist-in 5.925 APE9-dist-in 3.214 None None None XRAY 1.9 0.204 0.236 A 322 272 7 0 0 0 [[9, 265]] 1.0 2hog CAMK_CHEK1_HUMAN CAMK 3.9e-71 245.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2HXLA O14757 2 276 476.0 422:324 Type1 Active DFGin 6.846 14.071 BLAminus DFGAsp-rot-in -130.75, 166.76 70.33, 92.55 189.65, 2.43 -103.77, 30.08 290.87, 84.03 -71.02, -25.09 in-in in 8.678 Saltbr-in 2.947 HRD-in -72.98, -44.67 70.07, 1.52 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.32, 153.75 APE9-dihe-na 120.45, -160.19 APE8-dihe-in -131.74, 120.76 APE8-rot-in 304.55 APE67-dihe-in -61.62, -21.58 -33.66, -54.8 APE12-dist-in 9.16 APE11-dist-in 11.242 APE10-dist-in 5.758 APE9-dist-in 3.296 None None None XRAY 1.8 0.24 0.27 A 322 272 3 0 0 0 [[9, 265]] 1.0 2hxl CAMK_CHEK1_HUMAN CAMK 3.9e-71 245.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2QHMA O14757 2 280 476.0 7CS:500 Type1 Active DFGin 6.772 14.08 BLAminus DFGAsp-rot-in -128.04, 164.43 76.84, 101.69 200.0, -17.96 -108.83, 21.45 292.71, 82.54 -63.16, -31.58 in-in in 8.975 Saltbr-in 3.022 HRD-in -76.01, -44.64 71.83, -0.16 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.23, 170.83 APE9-dihe-na 117.51, -152.64 APE8-dihe-in -136.18, 123.8 APE8-rot-in 296.25 APE67-dihe-in -58.13, -21.13 -38.91, -55.77 APE12-dist-in 9.195 APE11-dist-in 11.636 APE10-dist-in 6.134 APE9-dist-in 3.16 None None None XRAY 2.0 0.195 0.237 A 323 268 11 0 0 0 [[9, 265]] 1.0 2qhm CAMK_CHEK1_HUMAN CAMK 4e-71 245.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2QHNA O14757 2 280 476.0 582:500 Type1 Active DFGin 6.88 14.133 BLAminus DFGAsp-rot-in -126.49, 161.83 70.32, 93.37 192.61, -9.01 -99.87, 25.92 292.06, 80.64 -63.7, -34.99 in-in in 8.792 Saltbr-in 2.746 HRD-in -76.39, -44.4 73.61, -2.54 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.44, 160.33 APE9-dihe-na 118.4, -157.67 APE8-dihe-in -138.42, 120.63 APE8-rot-in 297.79 APE67-dihe-in -60.96, -22.13 -36.11, -57.97 APE12-dist-in 9.21 APE11-dist-in 11.621 APE10-dist-in 5.881 APE9-dist-in 3.191 None None None XRAY 1.7 0.203 0.23 A 323 268 11 0 0 0 [[9, 265]] 1.0 2qhn CAMK_CHEK1_HUMAN CAMK 4e-71 245.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2R0UA O14757 2 280 476.0 M54:324 Type1 Active DFGin 6.879 14.783 BLAminus DFGAsp-rot-in -130.98, 175.0 63.44, 83.35 198.67, -1.84 -98.83, 22.14 288.69, 85.22 -65.61, -26.86 in-in in 8.562 Saltbr-in 2.792 HRD-in -79.55, -46.26 72.28, 2.27 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.26, 151.84 APE9-dihe-na 117.81, -152.92 APE8-dihe-in -133.39, 116.35 APE8-rot-in 302.77 APE67-dihe-in -61.49, -22.1 -35.67, -54.4 APE12-dist-in 9.247 APE11-dist-in 11.356 APE10-dist-in 6.137 APE9-dist-in 3.226 None None None XRAY 1.9 0.197 0.218 A 323 269 10 0 0 0 [[9, 265]] 1.0 2r0u CAMK_CHEK1_HUMAN CAMK 4e-71 245.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3TKHA O14757 2 280 476.0 07S:325 Type1 Active DFGin 7.036 14.129 BLAminus DFGAsp-rot-in -125.51, 167.65 65.08, 90.5 191.65, 1.07 -95.72, 21.17 290.82, 87.11 -61.09, -34.24 in-in in 8.501 Saltbr-in 2.814 HRD-in -73.35, -45.96 71.88, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.84, 155.22 APE9-dihe-na 115.35, -158.04 APE8-dihe-in -134.64, 120.26 APE8-rot-in 299.43 APE67-dihe-in -61.5, -21.36 -39.52, -53.35 APE12-dist-in 9.09 APE11-dist-in 11.256 APE10-dist-in 5.784 APE9-dist-in 3.223 None None None XRAY 1.79 0.184 0.201 A 323 269 10 0 0 0 [[9, 265]] 1.0 3tkh CAMK_CHEK1_HUMAN CAMK 4e-71 245.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 3TKIA O14757 2 280 476.0 S25:325 Type1 Active DFGin 7.066 14.047 BLAminus DFGAsp-rot-in -128.14, 167.81 66.79, 92.13 190.86, -10.08 -100.38, 25.08 290.04, 84.3 -65.02, -26.24 in-in in 8.512 Saltbr-in 2.702 HRD-in -75.61, -43.71 71.45, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.41, 152.37 APE9-dihe-na 119.25, -155.65 APE8-dihe-in -135.42, 118.76 APE8-rot-in 302.07 APE67-dihe-in -61.44, -22.09 -36.74, -54.05 APE12-dist-in 9.235 APE11-dist-in 11.298 APE10-dist-in 5.79 APE9-dist-in 3.237 None None None XRAY 1.6 0.188 0.212 A 323 272 7 0 0 0 [[9, 265]] 1.0 3tki CAMK_CHEK1_HUMAN CAMK 4e-71 245.3 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OQ5A O14757 3 270 476.0 4K4:301 Type1 Active DFGin 7.212 14.393 BLAminus DFGAsp-rot-in -137.57, 166.94 72.85, 88.19 194.05, -17.2 -97.66, 22.2 287.41, 72.48 -72.17, -15.94 in-in in 9.401 Saltbr-in 2.848 HRD-in -76.62, -42.87 75.17, -5.02 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.87, 165.21 APE9-dihe-na 121.43, -145.46 APE8-dihe-in -135.47, 115.76 APE8-rot-in 308.05 APE67-dihe-in -59.16, -21.13 -45.59, -50.3 APE12-dist-in 9.114 APE11-dist-in 11.477 APE10-dist-in 6.308 APE9-dist-in 3.513 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A None None XRAY 1.4 0.17 0.185 A 297 265 3 0 0 0 [[9, 265]] 1.0 5oq5 CAMK_CHEK1_HUMAN CAMK 1.1e-70 243.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OQ7A O14757 8 271 476.0 A0Q:301 Type1 Active DFGin 7.123 14.284 BLAminus DFGAsp-rot-in -115.9, 149.42 83.67, 113.44 202.31, -58.25 -120.56, 20.12 282.1, 87.3 -60.35, -30.28 in-in in 9.129 Saltbr-in 2.185 HRD-in -72.95, -46.31 71.63, 7.81 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.79, 177.88 APE9-dihe-na 107.24, -147.89 APE8-dihe-in -133.83, 123.88 APE8-rot-in 304.96 APE67-dihe-in -60.86, -17.32 -51.61, -47.12 APE12-dist-in 9.968 APE11-dist-in 11.63 APE10-dist-in 6.087 APE9-dist-in 3.712 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A None None XRAY 2.1 0.259 0.324 A 297 259 5 0 0 0 [[9, 265]] 1.0 5oq7 CAMK_CHEK1_HUMAN CAMK 1.1e-70 243.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OQ7B O14757 8 270 476.0 A0Q:301 Type1 Active DFGin 7.007 13.668 BLAminus DFGAsp-rot-in -123.41, 144.51 76.15, 112.19 175.17, 52.47 -116.09, 30.53 288.02, 74.92 -74.13, -26.43 in-in in 8.562 Saltbr-in 3.412 HRD-in -68.73, -47.06 88.33, -2.49 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.0, 169.92 APE9-dihe-na 126.71, -154.19 APE8-dihe-in -137.81, 141.49 APE8-rot-in 282.73 APE67-dihe-in -51.67, -38.82 -61.07, -53.98 APE12-dist-in 9.025 APE11-dist-in 11.512 APE10-dist-in 6.116 APE9-dist-in 3.699 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A None None XRAY 2.1 0.259 0.324 B 297 256 7 0 0 0 [[9, 265]] 1.0 5oq7 CAMK_CHEK1_HUMAN CAMK 1.1e-70 243.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSUA O14757 4 271 476.0 HK5:301 Type1 Active DFGin 6.925 14.242 BLAminus DFGAsp-rot-in -130.65, 164.24 65.93, 99.19 200.22, -31.9 -104.79, 24.05 288.61, 85.53 -67.15, -26.86 in-in in 8.688 Saltbr-in 2.717 HRD-in -71.9, -47.68 71.19, 6.28 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.25, 165.58 APE9-dihe-na 117.09, -150.06 APE8-dihe-in -133.92, 119.44 APE8-rot-in 307.97 APE67-dihe-in -62.25, -20.9 -38.55, -52.24 APE12-dist-in 9.127 APE11-dist-in 11.471 APE10-dist-in 6.003 APE9-dist-in 3.306 None None None XRAY 2.1 0.173 0.181 A 279 260 8 0 0 0 [[9, 265]] 1.0 4fsu CAMK_CHEK1_HUMAN CAMK 7.5e-71 244.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OQ6A O14757 5 270 476.0 4K4:301 Type1 Active DFGin 6.952 13.956 BLAminus DFGAsp-rot-in -116.27, 166.19 73.35, 97.82 200.28, -22.29 -108.78, 21.61 291.33, 79.85 -70.94, -23.48 in-in in 9.39 Saltbr-in 2.768 HRD-in -76.04, -43.87 68.12, 2.56 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.4, 175.01 APE9-dihe-na 115.83, -158.06 APE8-dihe-in -132.34, 123.75 APE8-rot-in 301.05 APE67-dihe-in -65.69, -17.68 -49.58, -46.31 APE12-dist-in 9.232 APE11-dist-in 11.239 APE10-dist-in 5.945 APE9-dist-in 3.435 A19S,Y20F,N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.95 0.16 0.192 A 297 257 9 0 0 0 [[9, 265]] 1.0 5oq6 CAMK_CHEK1_HUMAN CAMK 1.8e-69 239.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OQ8A O14757 4 270 476.0 A0Q:301 Type1 Active DFGin 6.976 13.708 BLAminus DFGAsp-rot-in -114.65, 171.07 70.74, 94.75 183.66, 13.93 -100.36, 20.44 291.87, 83.91 -68.92, -28.4 in-in in 8.527 Saltbr-in 3.218 HRD-in -74.36, -44.04 71.63, 3.1 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.21, 175.51 APE9-dihe-na 117.46, -150.37 APE8-dihe-in -131.31, 125.96 APE8-rot-in 300.85 APE67-dihe-in -65.06, -17.09 -46.84, -53.17 APE12-dist-in 8.854 APE11-dist-in 11.643 APE10-dist-in 6.306 APE9-dist-in 3.561 A19S,Y20F,N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.167 0.2 A 297 261 6 0 0 0 [[9, 265]] 1.0 5oq8 CAMK_CHEK1_HUMAN CAMK 1.8e-69 239.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 9CE4A O14757 4 271 476.0 A1AV4:301 Type1 Active DFGin 7.2 13.454 BLAminus DFGAsp-rot-in -119.78, 162.88 71.89, 104.85 194.17, -26.62 -111.17, 21.45 289.63, 81.1 -64.05, -28.25 in-in in 9.118 Saltbr-in 3.069 HRD-in -74.27, -45.02 73.63, 3.4 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.42, 168.37 APE9-dihe-na 118.29, -153.71 APE8-dihe-in -135.96, 121.9 APE8-rot-in 300.47 APE67-dihe-in -61.86, -20.64 -47.17, -48.09 APE12-dist-in 8.867 APE11-dist-in 11.566 APE10-dist-in 6.067 APE9-dist-in 3.326 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.31 0.184 0.221 A 268 258 10 0 0 0 [[9, 265]] 1.0 9ce4 CAMK_CHEK1_HUMAN CAMK 3.4e-69 239.0 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OOTA O14757 4 270 476.0 4K4:301 Type1 Active DFGin 6.886 13.873 BLAminus DFGAsp-rot-in -123.71, 160.5 78.56, 100.42 188.08, -4.49 -111.81, 22.75 292.67, 78.9 -75.98, -17.85 in-in in 9.323 Saltbr-in 2.824 HRD-in -78.85, -47.77 75.66, -4.37 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.46, 155.57 APE9-dihe-na 122.12, -167.22 APE8-dihe-in -131.08, 125.87 APE8-rot-in 298.0 APE67-dihe-in -65.3, -21.81 -53.02, -44.26 APE12-dist-in 9.155 APE11-dist-in 11.18 APE10-dist-in 5.735 APE9-dist-in 3.446 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.1 0.178 0.224 A 297 260 7 0 0 0 [[9, 265]] 1.0 5oot CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OP2A O14757 4 271 476.0 A0Q:301 Type1 Active DFGin 6.975 13.81 BLAminus DFGAsp-rot-in -113.46, 163.41 77.81, 100.2 183.98, 5.42 -106.41, 21.36 291.61, 81.69 -69.8, -25.56 in-in in 8.491 Saltbr-in 3.191 HRD-in -77.36, -46.21 76.3, -1.69 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.61, 173.53 APE9-dihe-na 118.89, -148.19 APE8-dihe-in -135.3, 122.77 APE8-rot-in 300.97 APE67-dihe-in -69.82, -15.47 -49.44, -44.8 APE12-dist-in 9.453 APE11-dist-in 11.716 APE10-dist-in 6.284 APE9-dist-in 3.551 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.161 0.2 A 297 263 5 0 0 0 [[9, 265]] 1.0 5op2 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OP4A O14757 3 270 476.0 A0T:301 Type1 Active DFGin 6.958 13.676 BLAminus DFGAsp-rot-in -120.25, 163.52 72.52, 97.08 198.34, -19.63 -105.73, 22.62 289.58, 82.01 -73.58, -24.61 in-in in 9.18 Saltbr-in 2.607 HRD-in -76.46, -44.61 73.33, 0.98 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.0, 176.3 APE9-dihe-na 113.44, -150.07 APE8-dihe-in -134.9, 124.12 APE8-rot-in 296.27 APE67-dihe-in -63.53, -18.17 -48.69, -47.33 APE12-dist-in 9.066 APE11-dist-in 11.571 APE10-dist-in 6.194 APE9-dist-in 3.507 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.169 0.205 A 297 259 9 0 0 0 [[9, 265]] 1.0 5op4 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OP5A O14757 4 270 476.0 3FE:301 Type1 Active DFGin 7.143 13.656 BLAminus DFGAsp-rot-in -111.04, 162.46 74.82, 99.79 206.83, -37.61 -113.07, 20.16 292.98, 78.11 -70.13, -26.75 in-in in 9.394 Saltbr-in 2.894 HRD-in -76.35, -46.93 73.16, 0.06 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.71, 173.57 APE9-dihe-na 115.19, -153.36 APE8-dihe-in -133.92, 122.39 APE8-rot-in 297.32 APE67-dihe-in -67.39, -15.82 -48.27, -44.76 APE12-dist-in 8.865 APE11-dist-in 11.706 APE10-dist-in 6.215 APE9-dist-in 3.408 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.162 0.206 A 297 259 8 0 0 0 [[9, 265]] 1.0 5op5 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OP7A O14757 4 270 476.0 A1K:301 Type1 Active DFGin 7.07 13.523 BLAminus DFGAsp-rot-in -119.38, 164.65 74.16, 96.12 194.84, -32.62 -105.6, 23.88 293.2, 80.09 -71.41, -20.33 in-in in 9.375 Saltbr-in 3.062 HRD-in -82.06, -43.11 72.25, 1.02 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.04, 177.16 APE9-dihe-na 111.37, -152.73 APE8-dihe-in -135.08, 120.27 APE8-rot-in 299.86 APE67-dihe-in -68.14, -17.85 -45.44, -46.06 APE12-dist-in 9.049 APE11-dist-in 11.652 APE10-dist-in 6.145 APE9-dist-in 3.4 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.8 0.168 0.215 A 297 261 6 0 0 0 [[9, 265]] 1.0 5op7 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OPBA O14757 5 271 476.0 A1N:301 Type1 Active DFGin 6.928 13.631 BLAminus DFGAsp-rot-in -127.5, 170.57 73.1, 96.55 180.43, 12.35 -104.05, 19.63 293.23, 83.02 -63.66, -29.12 in-in in 8.49 Saltbr-in 3.041 HRD-in -78.76, -48.56 80.79, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.16, 173.26 APE9-dihe-na 113.85, -143.9 APE8-dihe-in -134.72, 122.47 APE8-rot-in 308.74 APE67-dihe-in -59.7, -23.28 -50.86, -47.55 APE12-dist-in 9.376 APE11-dist-in 11.665 APE10-dist-in 6.233 APE9-dist-in 3.579 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.55 0.165 0.189 A 297 262 5 0 0 0 [[9, 265]] 1.0 5opb CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OPRA O14757 4 270 476.0 A3E:301 Type1 Active DFGin 6.957 13.557 BLAminus DFGAsp-rot-in -118.63, 168.17 71.59, 95.55 187.42, -1.42 -107.46, 21.7 291.34, 81.1 -71.92, -24.17 in-in in 9.22 Saltbr-in 2.75 HRD-in -75.64, -44.16 68.61, -1.61 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.69, 179.14 APE9-dihe-na 109.46, -150.3 APE8-dihe-in -134.98, 121.9 APE8-rot-in 296.29 APE67-dihe-in -64.62, -18.13 -48.76, -45.83 APE12-dist-in 8.759 APE11-dist-in 11.804 APE10-dist-in 6.28 APE9-dist-in 3.415 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.95 0.166 0.206 A 297 258 9 0 0 0 [[9, 265]] 1.0 5opr CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OPSA O14757 3 270 476.0 A3Q:301 Type1 Active DFGin 6.979 13.573 BLAminus DFGAsp-rot-in -124.54, 166.57 74.59, 94.68 190.81, 0.31 -104.11, 23.06 293.13, 78.93 -70.21, -22.8 in-in in 9.235 Saltbr-in 2.889 HRD-in -76.05, -44.37 71.1, -0.07 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.5, 174.02 APE9-dihe-na 119.54, -152.79 APE8-dihe-in -133.46, 124.35 APE8-rot-in 295.76 APE67-dihe-in -58.43, -25.41 -48.38, -48.15 APE12-dist-in 9.124 APE11-dist-in 11.654 APE10-dist-in 6.24 APE9-dist-in 3.516 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.163 0.202 A 297 258 10 0 0 0 [[9, 265]] 1.0 5ops CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OPUA O14757 3 271 476.0 A3K:301 Type1 Active DFGin 7.057 13.473 BLAminus DFGAsp-rot-in -118.42, 161.45 74.22, 104.07 196.29, -42.06 -109.02, 22.53 294.09, 83.39 -63.01, -33.06 in-in in 9.238 Saltbr-in 2.676 HRD-in -82.38, -42.44 75.35, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.28, 171.71 APE9-dihe-na 121.99, -160.54 APE8-dihe-in -131.47, 121.55 APE8-rot-in 303.24 APE67-dihe-in -61.44, -19.07 -47.23, -48.74 APE12-dist-in 9.143 APE11-dist-in 11.703 APE10-dist-in 6.177 APE9-dist-in 3.481 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.55 0.172 0.206 A 297 261 8 0 0 0 [[9, 265]] 1.0 5opu CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5OPVA O14757 3 270 476.0 A3H:301 Type1 Active DFGin 6.96 13.606 BLAminus DFGAsp-rot-in -121.69, 163.58 77.05, 97.9 201.63, -21.47 -108.91, 21.22 289.09, 85.65 -63.92, -35.33 in-in in 9.186 Saltbr-in 2.453 HRD-in -77.36, -47.2 74.21, -3.64 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.2, 172.7 APE9-dihe-na 122.38, -151.0 APE8-dihe-in -136.47, 125.7 APE8-rot-in 297.44 APE67-dihe-in -66.18, -19.24 -51.65, -45.72 APE12-dist-in 9.25 APE11-dist-in 11.717 APE10-dist-in 6.255 APE9-dist-in 3.504 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.166 0.204 A 297 261 7 0 0 0 [[9, 265]] 1.0 5opv CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJDA O14757 3 270 476.0 TVT:301 Type1 Active DFGin 7.084 13.659 BLAminus DFGAsp-rot-in -125.76, 163.02 71.86, 96.41 189.8, -5.86 -103.13, 21.61 289.17, 82.5 -71.88, -23.03 in-in in 8.887 Saltbr-in 2.9 HRD-in -76.23, -50.44 76.99, 0.19 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.69, 177.15 APE9-dihe-na 113.59, -153.08 APE8-dihe-in -130.22, 124.06 APE8-rot-in 306.43 APE67-dihe-in -62.37, -19.5 -51.28, -48.54 APE12-dist-in 9.017 APE11-dist-in 11.599 APE10-dist-in 6.089 APE9-dist-in 3.331 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.164 0.197 A 297 263 5 0 0 0 [[9, 265]] 1.0 7bjd CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJEA O14757 4 270 476.0 ADE:301 Type1 Active DFGin 7.057 13.586 BLAminus DFGAsp-rot-in -121.21, 160.63 79.82, 94.56 194.38, -19.05 -105.52, 22.95 292.15, 82.58 -70.69, -20.75 in-in in 9.168 Saltbr-in 2.978 HRD-in -77.37, -47.27 75.12, 0.05 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.98, 175.66 APE9-dihe-na 111.76, -150.84 APE8-dihe-in -133.41, 122.32 APE8-rot-in 300.48 APE67-dihe-in -64.02, -19.73 -50.61, -46.69 APE12-dist-in 8.933 APE11-dist-in 11.738 APE10-dist-in 6.194 APE9-dist-in 3.38 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.8 0.173 0.199 A 297 259 8 0 0 0 [[9, 265]] 1.0 7bje CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJHA O14757 3 270 476.0 42C:301 Type1 Active DFGin 7.039 13.667 BLAminus DFGAsp-rot-in -116.34, 165.35 72.91, 98.36 198.1, -30.27 -107.78, 21.47 288.28, 79.82 -69.94, -23.59 in-in in 9.239 Saltbr-in 2.782 HRD-in -77.33, -48.21 78.81, 0.79 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.22, 175.12 APE9-dihe-na 118.78, -150.24 APE8-dihe-in -133.09, 120.06 APE8-rot-in 303.88 APE67-dihe-in -64.34, -19.53 -50.28, -45.23 APE12-dist-in 9.002 APE11-dist-in 11.736 APE10-dist-in 6.218 APE9-dist-in 3.433 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.8 0.173 0.201 A 297 260 8 0 0 0 [[9, 265]] 1.0 7bjh CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJJA O14757 3 270 476.0 TVW:301 Type1 Active DFGin 7.065 13.659 BLAminus DFGAsp-rot-in -124.47, 161.87 75.65, 95.41 190.34, -4.74 -106.95, 21.08 288.5, 86.21 -71.04, -20.76 in-in in 9.294 Saltbr-in 2.932 HRD-in -76.46, -47.86 74.54, -0.21 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.52, 179.25 APE9-dihe-na 107.66, -150.8 APE8-dihe-in -135.65, 121.21 APE8-rot-in 299.15 APE67-dihe-in -63.43, -20.51 -51.77, -45.13 APE12-dist-in 9.114 APE11-dist-in 11.71 APE10-dist-in 6.256 APE9-dist-in 3.337 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.8 0.173 0.199 A 297 260 8 0 0 0 [[9, 265]] 1.0 7bjj CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJOA O14757 5 271 476.0 TWK:301 Type1 Active DFGin 7.063 13.645 BLAminus DFGAsp-rot-in -119.72, 158.64 80.12, 94.27 188.93, -9.44 -104.94, 21.07 290.11, 79.57 -69.06, -22.79 in-in in 9.503 Saltbr-in 2.64 HRD-in -81.64, -47.92 81.07, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.78, 172.47 APE9-dihe-na 110.38, -152.68 APE8-dihe-in -132.39, 122.75 APE8-rot-in 300.0 APE67-dihe-in -67.01, -18.62 -51.35, -43.85 APE12-dist-in 8.924 APE11-dist-in 11.792 APE10-dist-in 6.242 APE9-dist-in 3.469 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.3 0.165 0.207 A 297 257 10 0 0 0 [[9, 265]] 1.0 7bjo CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJRA O14757 5 270 476.0 TWH:301 Type1 Active DFGin 6.963 13.498 BLAminus DFGAsp-rot-in -124.23, 160.3 73.7, 98.78 195.15, -30.3 -105.4, 21.99 292.68, 81.21 -49.01, -45.76 in-in in 9.066 Saltbr-in 3.046 HRD-in -75.2, -49.25 73.18, 6.16 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.32, 175.86 APE9-dihe-na 108.36, -150.65 APE8-dihe-in -133.02, 123.34 APE8-rot-in 301.05 APE67-dihe-in -62.65, -20.92 -50.03, -48.58 APE12-dist-in 8.838 APE11-dist-in 11.799 APE10-dist-in 6.257 APE9-dist-in 3.4 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.9 0.17 0.192 A 297 257 9 0 0 0 [[9, 265]] 1.0 7bjr CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJXA O14757 8 270 476.0 U0Q:301 Type1 Active DFGin 6.968 14.013 BLAminus DFGAsp-rot-in -119.16, 168.61 74.53, 87.65 188.26, 26.44 -98.83, 25.0 288.63, 92.62 -71.16, -25.36 in-in in 8.842 Saltbr-in 2.732 HRD-in -66.51, -58.83 81.76, -3.62 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.31, 174.42 APE9-dihe-na 110.98, -158.13 APE8-dihe-in -122.51, 124.96 APE8-rot-in 305.1 APE67-dihe-in -66.42, -15.88 -52.33, -43.64 APE12-dist-in 8.815 APE11-dist-in 11.547 APE10-dist-in 6.103 APE9-dist-in 3.512 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.4 0.204 0.26 A 297 255 8 0 0 0 [[9, 265]] 1.0 7bjx CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BJXB O14757 8 270 476.0 U0Q:301 Type1 Active DFGin 7.008 13.879 BLAminus DFGAsp-rot-in -129.53, 170.8 70.69, 86.19 176.72, 2.84 -101.81, 34.09 285.2, 93.96 -77.01, -26.91 in-in in 9.087 Saltbr-in 3.266 HRD-in -62.72, -54.04 75.21, -2.93 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.42, 172.2 APE9-dihe-na 111.07, -153.42 APE8-dihe-in -130.98, 128.58 APE8-rot-in 299.81 APE67-dihe-in -59.32, -22.77 -56.3, -49.67 APE12-dist-in 8.587 APE11-dist-in 11.566 APE10-dist-in 6.022 APE9-dist-in 3.621 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.4 0.204 0.26 B 297 252 11 0 0 0 [[9, 265]] 1.0 7bjx CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BK1A O14757 8 271 476.0 U0N:301 Type1 Active DFGin 6.8 13.783 BLAminus DFGAsp-rot-in -121.8, 173.16 69.15, 89.56 188.3, 15.25 -98.11, 18.64 290.94, 87.09 -66.87, -20.33 in-in in 8.546 Saltbr-in 3.38 HRD-in -76.9, -49.43 72.98, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.0, 174.77 APE9-dihe-na 112.34, -139.81 APE8-dihe-in -141.03, 122.43 APE8-rot-in 302.84 APE67-dihe-in -62.03, -22.5 -53.49, -49.69 APE12-dist-in 9.205 APE11-dist-in 11.678 APE10-dist-in 6.206 APE9-dist-in 3.494 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.192 0.235 A 297 257 7 0 0 0 [[9, 265]] 1.0 7bk1 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BK2A O14757 5 271 476.0 U0K:301 Type1 Active DFGin 6.89 13.774 BLAminus DFGAsp-rot-in -124.82, 175.43 66.05, 93.67 186.52, 10.23 -102.6, 23.32 290.62, 82.89 -71.81, -20.62 in-in in 8.786 Saltbr-in 3.063 HRD-in -73.35, -50.82 74.75, 4.72 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.63, 173.84 APE9-dihe-na 113.99, -151.94 APE8-dihe-in -129.35, 119.79 APE8-rot-in 306.75 APE67-dihe-in -61.35, -18.19 -45.89, -53.1 APE12-dist-in 9.199 APE11-dist-in 11.66 APE10-dist-in 6.227 APE9-dist-in 3.529 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.16 0.197 A 297 261 6 0 0 0 [[9, 265]] 1.0 7bk2 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7BK3A O14757 5 271 476.0 U0T:301 Type1 Active DFGin 6.904 13.759 BLAminus DFGAsp-rot-in -123.18, 173.88 64.54, 96.63 187.02, 14.26 -101.84, 19.24 289.62, 86.83 -69.92, -22.88 in-in in 8.744 Saltbr-in 3.063 HRD-in -77.61, -49.43 74.89, 4.0 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.55, 173.32 APE9-dihe-na 112.42, -148.12 APE8-dihe-in -134.42, 118.62 APE8-rot-in 305.11 APE67-dihe-in -61.9, -17.64 -49.91, -49.05 APE12-dist-in 9.145 APE11-dist-in 11.641 APE10-dist-in 6.172 APE9-dist-in 3.561 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.0 0.173 0.225 A 297 261 6 0 0 0 [[9, 265]] 1.0 7bk3 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7MCKA O14757 4 271 476.0 YXD:301 Type1 Active DFGin 7.091 13.493 BLAminus DFGAsp-rot-in -116.14, 168.88 70.05, 99.13 186.15, 0.57 -109.49, 22.2 291.12, 80.38 -65.63, -23.95 in-in in 9.043 Saltbr-in 2.85 HRD-in -72.23, -49.13 74.37, 1.18 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.37, 168.45 APE9-dihe-na 112.73, -156.62 APE8-dihe-in -133.72, 119.69 APE8-rot-in 302.23 APE67-dihe-in -64.04, -21.06 -43.31, -48.42 APE12-dist-in 8.853 APE11-dist-in 11.364 APE10-dist-in 5.852 APE9-dist-in 3.274 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.65 0.194 0.225 A 297 263 5 0 0 0 [[9, 265]] 1.0 7mck CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7SUFA O14757 3 271 476.0 BVI:301 Type1 Active DFGin 7.129 13.724 BLAminus DFGAsp-rot-in -103.46, 166.86 70.95, 94.53 198.87, -15.94 -102.33, 19.69 289.72, 86.68 -81.72, -14.95 in-in in 8.962 Saltbr-in 2.915 HRD-in -77.79, -44.59 69.25, -2.58 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.93, 167.68 APE9-dihe-na 123.94, -141.99 APE8-dihe-in -136.26, 119.39 APE8-rot-in 302.86 APE67-dihe-in -66.27, -16.33 -43.58, -49.38 APE12-dist-in 8.865 APE11-dist-in 11.886 APE10-dist-in 6.357 APE9-dist-in 3.433 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.48 0.219 0.254 A 297 262 7 0 0 0 [[9, 265]] 1.0 7suf CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7SUGA O14757 3 271 476.0 BWI:301 Type1 Active DFGin 7.129 13.724 BLAminus DFGAsp-rot-in -103.46, 166.86 70.95, 94.53 198.87, -15.94 -102.33, 19.69 289.72, 86.68 -81.72, -14.95 in-in in 8.962 Saltbr-in 2.915 HRD-in -77.79, -44.59 69.25, -2.58 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.93, 167.68 APE9-dihe-na 123.94, -141.99 APE8-dihe-in -136.26, 119.39 APE8-rot-in 302.86 APE67-dihe-in -66.27, -16.33 -43.58, -49.38 APE12-dist-in 8.865 APE11-dist-in 11.886 APE10-dist-in 6.357 APE9-dist-in 3.433 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.48 0.219 0.254 A 297 262 7 0 0 0 [[9, 265]] 1.0 7sug CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7SUHA O14757 4 270 476.0 BXI:301 Type1 Active DFGin 6.978 13.326 BLAminus DFGAsp-rot-in -119.38, 174.44 58.17, 102.88 193.67, -1.37 -112.43, 21.51 291.89, 87.3 -72.91, -23.6 in-in in 8.852 Saltbr-in 3.185 HRD-in -70.43, -44.77 72.79, -5.18 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.3, 155.5 APE9-dihe-na 121.03, -162.94 APE8-dihe-in -122.22, 120.31 APE8-rot-in 306.81 APE67-dihe-in -68.29, -12.17 -40.69, -51.31 APE12-dist-in 9.442 APE11-dist-in 11.601 APE10-dist-in 5.663 APE9-dist-in 3.413 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.46 0.179 0.242 A 297 261 6 0 0 0 [[9, 265]] 1.0 7suh CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7SUIA O14757 4 271 476.0 L80:301 Type1 Active DFGin 7.177 13.406 BLAminus DFGAsp-rot-in -121.13, 166.3 71.09, 92.03 195.25, 29.83 -104.59, 27.98 295.97, 86.18 -75.46, -22.7 in-in in 8.839 Saltbr-in 2.898 HRD-in -71.84, -40.65 70.78, 1.39 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.06, 169.5 APE9-dihe-na 112.95, -154.55 APE8-dihe-in -128.22, 124.64 APE8-rot-in 306.77 APE67-dihe-in -64.51, -20.74 -44.43, -49.5 APE12-dist-in 9.043 APE11-dist-in 11.419 APE10-dist-in 6.15 APE9-dist-in 3.337 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.119 0.198 0.253 A 297 262 6 0 0 0 [[9, 265]] 1.0 7sui CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 7SUJB O14757 9 271 476.0 BYL:301 Type1 Active DFGin 7.063 13.351 BLAminus DFGAsp-rot-in -112.78, 164.5 67.33, 98.63 194.55, 15.6 -107.71, 27.22 294.65, 84.19 -67.75, -27.67 in-in in 9.085 Saltbr-in 2.773 HRD-in -62.4, -45.85 74.76, 2.41 in-in-in SNCiii in-in ActLoopNT-in 3.119 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.97, 179.8 APE9-dihe-na 104.39, -157.62 APE8-dihe-in -121.39, 118.56 APE8-rot-in 300.57 APE67-dihe-in -61.22, -23.9 -41.31, -48.21 APE12-dist-in 9.069 APE11-dist-in 11.344 APE10-dist-in 6.076 APE9-dist-in 3.595 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 2.299 0.236 0.297 B 297 256 7 0 0 0 [[9, 265]] 1.0 7suj CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8E80A O14757 8 271 476.0 UUF:301 Type1 Active DFGin 6.948 13.561 BLAminus DFGAsp-rot-in -116.38, 163.51 69.37, 105.0 197.19, -37.66 -111.89, 20.17 292.16, 81.73 -65.53, -30.68 in-in in 8.579 Saltbr-in 2.859 HRD-in -73.57, -45.75 72.69, 0.21 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.33, 170.54 APE9-dihe-na 117.83, -149.18 APE8-dihe-in -134.92, 121.74 APE8-rot-in 303.05 APE67-dihe-in -62.91, -20.27 -44.12, -51.23 APE12-dist-in 9.365 APE11-dist-in 11.644 APE10-dist-in 6.142 APE9-dist-in 3.497 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.49 0.209 0.242 A 297 258 6 0 0 0 [[9, 265]] 1.0 8e80 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8E81A O14757 4 271 476.0 UU6:301 Type1 Active DFGin 6.979 13.519 BLAminus DFGAsp-rot-in -118.37, 171.91 69.05, 96.38 192.03, 2.12 -109.23, 17.13 291.1, 85.02 -68.03, -21.82 in-in in 8.54 Saltbr-in 2.811 HRD-in -71.07, -47.85 72.59, 1.56 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.53, 170.33 APE9-dihe-na 117.5, -149.69 APE8-dihe-in -131.89, 120.45 APE8-rot-in 306.67 APE67-dihe-in -61.07, -20.65 -40.19, -52.75 APE12-dist-in 9.097 APE11-dist-in 11.72 APE10-dist-in 6.209 APE9-dist-in 3.5 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.62 0.202 0.232 A 297 260 8 0 0 0 [[9, 265]] 1.0 8e81 CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8SIVA O14757 4 271 476.0 ZXH:301 Type1 Active DFGin 7.059 13.482 BLAminus DFGAsp-rot-in -115.5, 167.7 64.71, 99.66 202.66, -9.79 -107.46, 23.74 294.38, 80.14 -66.51, -23.78 in-in in 8.877 Saltbr-in 2.711 HRD-in -72.41, -42.95 71.54, 5.65 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.84, 161.6 APE9-dihe-na 121.92, -152.74 APE8-dihe-in -132.25, 119.29 APE8-rot-in 305.39 APE67-dihe-in -62.23, -20.9 -40.75, -52.74 APE12-dist-in 9.191 APE11-dist-in 11.416 APE10-dist-in 6.076 APE9-dist-in 3.417 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.759 0.212 0.251 A 297 262 6 0 0 0 [[9, 265]] 1.0 8siv CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8SIWA O14757 4 271 476.0 ZXL:301 Type1 Active DFGin 6.994 13.683 BLAminus DFGAsp-rot-in -113.76, 162.62 69.21, 98.13 199.0, 12.18 -108.28, 26.75 295.75, 74.32 -69.16, -23.41 in-in in 8.71 Saltbr-in 2.743 HRD-in -66.18, -44.18 72.87, 0.87 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.9, 170.61 APE9-dihe-na 117.9, -150.99 APE8-dihe-in -129.35, 117.55 APE8-rot-in 300.72 APE67-dihe-in -66.83, -19.7 -40.71, -46.21 APE12-dist-in 8.819 APE11-dist-in 11.514 APE10-dist-in 6.096 APE9-dist-in 3.679 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.877 0.221 0.258 A 297 262 6 0 0 0 [[9, 265]] 1.0 8siw CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8SIWB O14757 4 271 476.0 ZXL:301 Type1 Active DFGin 7.084 13.507 BLAminus DFGAsp-rot-in -115.42, 169.51 62.16, 96.81 193.47, 15.2 -105.7, 27.61 296.32, 77.65 -65.5, -28.47 in-in in 8.929 Saltbr-in 2.748 HRD-in -74.62, -45.0 78.8, -4.37 in-in-in SNCiii in-in ActLoopNT-in 3.04 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.18, 179.28 APE9-dihe-na 113.08, -160.42 APE8-dihe-in -127.84, 114.47 APE8-rot-in 303.7 APE67-dihe-in -63.25, -25.25 -37.36, -47.37 APE12-dist-in 9.207 APE11-dist-in 11.509 APE10-dist-in 5.964 APE9-dist-in 3.785 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.877 0.221 0.258 B 297 262 6 0 0 0 [[9, 265]] 1.0 8siw CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 8SIXA O14757 8 271 476.0 ZXP:301 Type1 Active DFGin 7.025 13.666 BLAminus DFGAsp-rot-in -113.23, 174.49 65.61, 89.34 194.0, 14.06 -102.74, 20.94 292.25, 82.21 -67.34, -24.63 in-in in 8.747 Saltbr-in 2.893 HRD-in -71.81, -44.82 73.04, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.47, 164.55 APE9-dihe-na 122.25, -153.58 APE8-dihe-in -132.43, 118.01 APE8-rot-in 303.52 APE67-dihe-in -63.37, -20.97 -39.74, -51.03 APE12-dist-in 8.859 APE11-dist-in 11.462 APE10-dist-in 6.15 APE9-dist-in 3.581 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.55 0.207 0.238 A 297 258 6 0 0 0 [[9, 265]] 1.0 8six CAMK_CHEK1_HUMAN CAMK 5e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 5F4NA O14757 5 271 476.0 5UY:301,5UY:302 Type1,Allosteric Active DFGin 6.85 14.189 BLAminus DFGAsp-rot-in -128.01, 158.86 63.44, 104.21 204.72, -51.37 -106.87, 19.19 287.19, 84.71 -57.12, -35.21 in-in in 8.538 Saltbr-in 2.765 HRD-in -66.75, -44.88 70.14, 2.2 in-in-in SNCiii in-in ActLoopNT-in 3.016 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.7, 168.71 APE9-dihe-na 117.82, -151.09 APE8-dihe-in -134.05, 123.75 APE8-rot-in 301.55 APE67-dihe-in -60.69, -34.97 -48.53, -42.54 APE12-dist-in 9.306 APE11-dist-in 11.573 APE10-dist-in 6.142 APE9-dist-in 3.384 None None None XRAY 1.91 0.151 0.188 A 273 258 9 0 0 0 [[9, 265]] 1.0 5f4n CAMK_CHEK1_HUMAN CAMK 2.2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2YM7A O14757 7 271 476.0 YM7:1272,YM7:1273 Type1,Type1 Active DFGin 6.936 14.374 BLAminus DFGAsp-rot-in -121.61, 152.12 75.02, 94.15 195.04, -31.73 -102.21, 23.7 287.09, 83.66 -64.12, -27.24 in-in in 8.617 Saltbr-in 2.799 HRD-in -75.92, -44.81 73.37, 3.79 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.53, 155.48 APE9-dihe-na 116.48, -155.91 APE8-dihe-in -139.15, 124.89 APE8-rot-in 299.54 APE67-dihe-in -64.41, -21.42 -48.34, -47.99 APE12-dist-in 9.246 APE11-dist-in 11.336 APE10-dist-in 6.04 APE9-dist-in 3.28 None None None XRAY 1.81 0.174 0.204 A 289 248 17 0 0 0 [[9, 265]] 1.0 2ym7 CAMK_CHEK1_HUMAN CAMK 2.7e-71 245.9 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSTA O14757 3 270 476.0 HK4:301 Type1.5_Back Active DFGin 7.229 14.501 BLAminus DFGAsp-rot-in -123.14, 175.81 54.94, 88.88 197.27, -19.62 -99.29, 24.5 281.52, 82.61 -64.88, -24.05 in-in in 8.418 Saltbr-in 2.772 HRD-in -75.07, -48.0 73.01, 1.34 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.01, 150.39 APE9-dihe-na 119.8, -156.63 APE8-dihe-in -133.38, 118.41 APE8-rot-in 301.61 APE67-dihe-in -63.43, -18.37 -42.48, -49.9 APE12-dist-in 9.187 APE11-dist-in 11.315 APE10-dist-in 5.732 APE9-dist-in 3.259 None None CSO168 XRAY 1.9 0.167 0.185 A 269 254 14 0 0 0 [[9, 265]] 1.0 4fst CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2AYPA O14757 2 269 476.0 43A:270 Type1.5_Back Active DFGin 6.973 14.49 BLAminus DFGAsp-rot-in -138.37, 179.8 49.32, 90.63 203.12, -33.85 -98.25, 15.47 278.28, 78.06 -54.29, -32.89 in-in in 8.803 Saltbr-in 2.757 HRD-in -73.62, -38.68 66.73, -2.61 in-in-in SNCiii in-in ActLoopNT-in 2.994 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 176.43, 157.28 APE9-dihe-na 129.59, -138.97 APE8-dihe-in -134.95, 126.35 APE8-rot-in 306.63 APE67-dihe-in -76.36, 18.56 -42.31, -52.83 APE12-dist-in 9.588 APE11-dist-in 11.831 APE10-dist-in 6.529 APE9-dist-in 3.223 None None None XRAY 2.9 0.209 0.314 A 269 268 0 0 0 0 [[9, 265]] 1.0 2ayp CAMK_CHEK1_HUMAN CAMK 2e-71 246.2 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FSQA O14757 3 280 476.0 HK3:300 Type1.5_Back Active DFGin 6.999 14.384 BLAminus DFGAsp-rot-in -129.58, 171.1 67.76, 85.3 203.89, -26.37 -96.8, 25.85 288.0, 84.66 -67.55, -27.91 in-in in 8.985 Saltbr-in 2.905 HRD-in -68.52, -48.32 74.72, 0.91 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.05, 162.64 APE9-dihe-na 118.65, -156.24 APE8-dihe-in -131.59, 116.15 APE8-rot-in 306.21 APE67-dihe-in -63.38, -21.02 -38.07, -48.66 APE12-dist-in 9.125 APE11-dist-in 11.441 APE10-dist-in 5.932 APE9-dist-in 3.308 None None None XRAY 2.4 0.177 0.216 A 279 263 15 0 0 0 [[9, 265]] 1.0 4fsq CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTKA O14757 3 280 476.0 H9K:301 Type1.5_Back Active DFGin 7.006 14.35 BLAminus DFGAsp-rot-in -130.82, 170.32 67.66, 91.42 197.44, -22.94 -102.43, 26.27 286.08, 87.58 -70.64, -27.6 in-in in 8.994 Saltbr-in 3.235 HRD-in -69.86, -48.19 74.44, -1.22 in-in-in SNCiii in-in ActLoopNT-in 3.018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.22, 148.4 APE9-dihe-na 116.64, -159.27 APE8-dihe-in -130.65, 118.83 APE8-rot-in 306.3 APE67-dihe-in -62.59, -20.66 -41.67, -49.52 APE12-dist-in 9.226 APE11-dist-in 11.077 APE10-dist-in 5.707 APE9-dist-in 3.362 None None None XRAY 2.3 0.169 0.206 A 279 263 15 0 0 0 [[9, 265]] 1.0 4ftk CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTMA O14757 3 280 476.0 1HK:301 Type1.5_Back Active DFGin 7.037 14.296 BLAminus DFGAsp-rot-in -128.77, 171.8 60.97, 91.64 199.42, -7.86 -99.81, 22.79 284.09, 80.44 -66.65, -24.22 in-in in 8.579 Saltbr-in 2.878 HRD-in -76.62, -47.58 73.44, 1.96 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.98, 153.49 APE9-dihe-na 119.69, -162.07 APE8-dihe-in -132.76, 121.74 APE8-rot-in 303.64 APE67-dihe-in -62.56, -20.92 -44.23, -49.67 APE12-dist-in 9.165 APE11-dist-in 11.266 APE10-dist-in 5.796 APE9-dist-in 3.311 None None None XRAY 1.9 0.173 0.201 A 279 263 15 0 0 0 [[9, 265]] 1.0 4ftm CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 4FTNA O14757 3 271 476.0 2HK:301 Type1.5_Back Active DFGin 7.134 14.394 BLAminus DFGAsp-rot-in -134.9, 168.86 64.32, 92.93 199.39, -22.82 -102.31, 24.37 287.13, 80.28 -68.67, -25.41 in-in in 9.249 Saltbr-in 2.959 HRD-in -74.17, -47.98 73.35, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.01, 152.07 APE9-dihe-na 118.38, -157.24 APE8-dihe-in -135.4, 115.96 APE8-rot-in 302.06 APE67-dihe-in -63.78, -20.34 -42.05, -48.29 APE12-dist-in 9.139 APE11-dist-in 11.227 APE10-dist-in 5.753 APE9-dist-in 3.361 None None CSO168 XRAY 2.02 0.175 0.213 A 279 254 15 0 0 0 [[9, 265]] 1.0 4ftn CAMK_CHEK1_HUMAN CAMK 2.4e-71 246.1 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK1 CHK1_HUMAN 2C3KA O14757 6 270 476.0 ABO:1271 Type1.5_Back Active DFGin 7.015 14.31 BLAminus DFGAsp-rot-in -126.12, 172.55 61.71, 89.92 194.13, -6.02 -99.46, 20.99 290.88, 86.68 -65.91, -17.18 in-in in 8.634 Saltbr-in 2.867 HRD-in -71.43, -51.73 84.39, -4.25 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.82, 174.75 APE9-dihe-na 109.75, -155.16 APE8-dihe-in -124.52, 126.49 APE8-rot-in 296.43 APE67-dihe-in -70.39, -10.65 -47.18, -47.9 APE12-dist-in 9.19 APE11-dist-in 11.642 APE10-dist-in 6.119 APE9-dist-in 3.546 None None None XRAY 2.6 0.202 0.28 A 297 262 3 0 0 0 [[9, 265]] 1.0 2c3k CAMK_CHEK1_HUMAN CAMK 3e-71 245.7 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN AF-O96017-K1A O96017 212 494 543.0 No_ligand No_ligand Active DFGin 6.545 14.125 BLAminus DFGAsp-rot-in -134.29, 178.07 63.36, 67.46 202.88, 19.92 -81.42, 12.79 286.94, 80.33 -62.36, -24.52 in-in in 9.198 Saltbr-in 2.767 HRD-in -73.96, -47.53 67.01, -6.66 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.75, 160.77 APE9-dihe-na 92.75, 178.13 APE8-dihe-in -87.23, 123.5 APE8-rot-in 297.99 APE67-dihe-in -58.52, -25.91 -46.52, -43.3 APE12-dist-in 9.155 APE11-dist-in 11.399 APE10-dist-in 5.592 APE9-dist-in 4.172 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[220, 486]] 1.0 AF-O96017-K1 CAMK_CHEK2_HUMAN CAMK 1.3e-85 292.8 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK CHEK2 CHK2_HUMAN AF-O96017-K3A O96017 212 494 543.0 No_ligand No_ligand Active DFGin 6.461 14.071 BLAminus DFGAsp-rot-in -134.66, -179.17 61.2, 67.72 202.56, 8.52 -80.09, 11.6 287.9, 83.97 -61.23, -22.88 in-in in 9.059 Saltbr-in 2.743 HRD-in -76.36, -47.81 68.82, -4.77 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.66, 145.05 APE9-dihe-na 102.94, 172.88 APE8-dihe-in -82.21, 128.17 APE8-rot-in 302.29 APE67-dihe-in -66.9, -22.16 -48.63, -42.33 APE12-dist-in 9.52 APE11-dist-in 11.418 APE10-dist-in 5.934 APE9-dist-in 3.449 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[220, 486]] 1.0 AF-O96017-K3 CAMK_CHEK2_HUMAN CAMK 1.3e-85 292.8 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4KA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.672 14.178 BLAminus DFGAsp-rot-in -119.76, -176.11 66.35, 79.87 190.27, -0.11 -97.37, 22.41 282.66, 74.96 -63.58, -22.08 in-in in 9.11 Saltbr-in 2.829 HRD-in -72.34, -46.15 68.63, 4.94 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.51, 175.21 APE9-dihe-na 86.37, -178.83 APE8-dihe-in -92.32, 120.41 APE8-rot-in 301.2 APE67-dihe-in -65.94, -16.49 -43.92, -47.7 APE12-dist-in 9.204 APE11-dist-in 12.288 APE10-dist-in 6.82 APE9-dist-in 5.132 None None None XRAY 1.9 0.195 0.228 A 302 301 0 0 0 0 [[13, 275]] 1.0 2w4k CAMK_DAPK1_HUMAN CAMK 7e-95 323.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.814 14.3 BLAminus DFGAsp-rot-in -117.01, 179.93 67.97, 81.82 187.96, -1.12 -97.7, 27.63 286.42, 73.81 -75.99, -13.96 in-in in 9.047 Saltbr-in 2.623 HRD-in -76.48, -45.49 71.86, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.39, 167.91 APE9-dihe-na 89.82, 178.63 APE8-dihe-in -101.18, 124.0 APE8-rot-in 296.23 APE67-dihe-in -60.21, -22.55 -44.54, -47.64 APE12-dist-in 8.87 APE11-dist-in 11.727 APE10-dist-in 6.406 APE9-dist-in 5.145 E182A None None XRAY 1.8 0.179 0.226 A 334 301 0 0 0 0 [[13, 275]] 1.0 2xuu CAMK_DAPK1_HUMAN CAMK 1.4e-94 322.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1WVWA P53355 2 276 1430.0 No_ligand No_ligand Active DFGin 6.813 14.675 BLAminus DFGAsp-rot-in -117.72, -175.29 56.98, 85.6 195.36, -1.97 -98.34, 32.21 288.67, 74.66 -67.57, -24.56 in-in in 9.649 Saltbr-in 3.078 HRD-in -71.89, -47.97 68.59, 6.87 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.38, -169.08 APE9-dihe-na 75.38, -171.21 APE8-dihe-in -99.55, 117.51 APE8-rot-in 308.32 APE67-dihe-in -52.86, -25.91 -35.16, -54.38 APE12-dist-in 9.511 APE11-dist-in 12.152 APE10-dist-in 7.02 APE9-dist-in 5.156 None None None XRAY 2.4 0.232 0.27 A 278 275 0 0 0 0 [[13, 275]] 1.0 1wvw CAMK_DAPK1_HUMAN CAMK 5.1e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN AF-P53355-K1A P53355 5 283 1430.0 No_ligand No_ligand Active DFGin 6.909 14.131 BLAminus DFGAsp-rot-in -125.33, 176.46 60.35, 70.79 202.1, 20.34 -81.43, 20.35 284.08, 77.84 -63.2, -29.11 in-in in 9.265 Saltbr-in 2.725 HRD-in -73.48, -40.61 62.46, -2.36 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.83, -177.05 APE9-dihe-na 83.72, 177.12 APE8-dihe-in -83.88, 123.89 APE8-rot-in 300.98 APE67-dihe-in -70.13, -26.95 -51.24, -28.97 APE12-dist-in 9.181 APE11-dist-in 12.063 APE10-dist-in 6.462 APE9-dist-in 4.793 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[13, 275]] 1.0 AF-P53355-K1 CAMK_DAPK1_HUMAN CAMK 5.2e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN AF-P53355-K3A P53355 5 283 1430.0 No_ligand No_ligand Active DFGin 6.669 14.125 BLAminus DFGAsp-rot-in -124.11, -179.86 55.99, 73.83 202.46, 16.73 -79.33, 15.33 281.27, 78.38 -57.45, -32.96 in-in in 9.331 Saltbr-in 2.699 HRD-in -78.5, -40.79 62.16, -4.29 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.1, -172.61 APE9-dihe-na 81.13, 172.81 APE8-dihe-in -82.71, 125.76 APE8-rot-in 299.5 APE67-dihe-in -71.83, -30.16 -51.96, -28.46 APE12-dist-in 8.674 APE11-dist-in 11.831 APE10-dist-in 6.304 APE9-dist-in 4.642 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[13, 275]] 1.0 AF-P53355-K3 CAMK_DAPK1_HUMAN CAMK 5.2e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2Y0AA P53355 3 302 1430.0 No_ligand No_ligand Active DFGin 6.991 14.745 BLAminus DFGAsp-rot-in -121.23, 171.43 76.15, 81.22 202.25, -31.19 -98.04, 12.22 289.63, 69.6 -57.86, -12.4 in-in in 9.667 Saltbr-in 3.158 HRD-in -79.99, -38.28 67.74, 8.73 in-in-in SNCiii in-in ActLoopNT-in 3.118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.7, 178.89 APE9-dihe-na 85.05, 178.71 APE8-dihe-in -94.92, 123.63 APE8-rot-in 309.7 APE67-dihe-in -61.04, -25.29 -49.68, -40.62 APE12-dist-in 9.307 APE11-dist-in 12.361 APE10-dist-in 6.958 APE9-dist-in 5.176 None None None XRAY 2.6 0.203 0.259 A 326 300 0 0 0 0 [[13, 275]] 1.0 2y0a CAMK_DAPK1_HUMAN CAMK 9.2e-95 322.8 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 4TL0A P53355 2 301 1430.0 No_ligand No_ligand Active DFGin 6.925 14.89 BLAminus DFGAsp-rot-in -124.81, -178.45 60.49, 86.95 206.6, -15.62 -105.58, 31.94 286.67, 72.88 -73.98, -9.63 out-in out 10.007 Saltbr-in 3.34 HRD-in -75.1, -45.43 66.07, 12.75 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.84, -174.51 APE9-dihe-na 81.09, 179.66 APE8-dihe-in -88.92, 119.6 APE8-rot-in 306.62 APE67-dihe-in -77.38, -5.1 -43.93, -45.16 APE12-dist-in 9.303 APE11-dist-in 12.431 APE10-dist-in 7.052 APE9-dist-in 5.131 S289E None None XRAY 2.7 0.17 0.218 A 336 300 0 0 0 0 [[13, 275]] 1.0 4tl0 CAMK_DAPK1_HUMAN CAMK 1e-94 322.8 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 4B4LA P53355 5 303 1430.0 No_ligand No_ligand Active DFGin 6.995 14.506 BLAminus DFGAsp-rot-in -119.56, 174.11 66.67, 85.04 195.58, -9.35 -96.21, 24.97 284.46, 73.92 -64.79, -20.13 in-in in 9.318 Saltbr-in 2.81 HRD-in -75.61, -47.08 71.67, 4.3 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.99, 174.86 APE9-dihe-na 84.3, 177.65 APE8-dihe-in -99.0, 123.63 APE8-rot-in 303.03 APE67-dihe-in -63.95, -16.35 -47.13, -44.81 APE12-dist-in 9.036 APE11-dist-in 11.869 APE10-dist-in 6.369 APE9-dist-in 4.97 R302A None None XRAY 1.75 0.193 0.22 A 336 299 0 0 0 0 [[13, 275]] 1.0 4b4l CAMK_DAPK1_HUMAN CAMK 1e-94 322.8 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 6FHBA P53355 2 302 1430.0 No_ligand No_ligand Active DFGin 6.84 14.751 BLAminus DFGAsp-rot-in -122.08, 178.85 66.1, 78.91 196.35, -7.59 -96.45, 26.47 280.78, 78.37 -66.65, -19.39 in-in in 9.732 Saltbr-in 2.618 HRD-in -73.23, -46.94 69.77, 5.24 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.81, 179.51 APE9-dihe-na 84.79, -177.8 APE8-dihe-in -95.85, 119.34 APE8-rot-in 300.49 APE67-dihe-in -49.55, -30.82 -45.75, -47.57 APE12-dist-in 9.111 APE11-dist-in 12.341 APE10-dist-in 6.935 APE9-dist-in 5.192 S289A,S308E None None XRAY 1.75 0.189 0.222 A 337 301 0 0 0 0 [[13, 275]] 1.0 6fhb CAMK_DAPK1_HUMAN CAMK 1e-94 323.0 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 4TXCA P53355 2 277 1430.0 38G:301 Type1 Active DFGin 6.811 14.201 BLAminus DFGAsp-rot-in -120.96, -176.69 59.42, 88.35 194.85, -16.49 -102.5, 27.28 281.3, 72.82 -63.11, -27.69 in-in in 9.323 Saltbr-in 3.383 HRD-in -70.12, -49.86 70.15, 6.2 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.61, 178.73 APE9-dihe-na 81.03, -179.92 APE8-dihe-in -95.34, 124.45 APE8-rot-in 304.5 APE67-dihe-in -52.55, -30.95 -45.05, -46.9 APE12-dist-in 9.027 APE11-dist-in 12.226 APE10-dist-in 6.83 APE9-dist-in 5.052 None None None XRAY 1.951 0.181 0.216 A 304 276 0 0 0 0 [[13, 275]] 1.0 4txc CAMK_DAPK1_HUMAN CAMK 7.2e-95 323.1 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK2 DAPK2_HUMAN AF-Q9UIK4-K1A Q9UIK4 15 293 370.0 No_ligand No_ligand Active DFGin 6.737 14.239 BLAminus DFGAsp-rot-in -125.32, 174.59 58.75, 76.17 202.27, 12.11 -83.05, 18.0 284.14, 75.43 -59.61, -33.51 in-in in 9.135 Saltbr-in 2.714 HRD-in -75.9, -40.25 62.39, -2.72 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.72, -178.17 APE9-dihe-na 84.15, 175.65 APE8-dihe-in -84.33, 122.57 APE8-rot-in 300.43 APE67-dihe-in -62.19, -26.76 -48.87, -35.92 APE12-dist-in 9.14 APE11-dist-in 11.981 APE10-dist-in 6.411 APE9-dist-in 4.841 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K1 CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN AF-Q9UIK4-K3A Q9UIK4 15 293 370.0 No_ligand No_ligand Active DFGin 6.792 14.164 BLAminus DFGAsp-rot-in -129.71, 178.32 56.42, 68.87 201.98, 15.17 -80.44, 15.54 285.17, 79.99 -60.17, -30.61 in-in in 9.185 Saltbr-in 2.677 HRD-in -81.54, -39.53 61.7, 6.77 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.83, -174.16 APE9-dihe-na 83.87, 170.68 APE8-dihe-in -76.0, 126.83 APE8-rot-in 296.82 APE67-dihe-in -76.45, -22.52 -53.19, -25.87 APE12-dist-in 8.65 APE11-dist-in 11.681 APE10-dist-in 6.104 APE9-dist-in 4.249 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[23, 285]] 1.0 AF-Q9UIK4-K3 CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.1 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSA Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.576 14.283 BLAminus DFGAsp-rot-in -132.15, -167.45 56.41, 94.99 200.64, -46.19 -115.1, 28.9 282.7, 67.14 -71.51, -40.03 in-in in 9.278 Saltbr-in 2.788 HRD-in -64.12, -34.32 52.39, 5.5 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.54, 176.58 APE9-dihe-na 83.2, 172.18 APE8-dihe-in -70.67, 133.8 APE8-rot-in 287.45 APE67-dihe-in -61.47, -41.51 -48.38, -43.38 APE12-dist-in 9.394 APE11-dist-in 11.901 APE10-dist-in 6.479 APE9-dist-in 5.166 None None None XRAY 2.9 0.22 0.258 A 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSB Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.36 13.912 BLAminus DFGAsp-rot-in -137.19, -168.37 55.98, 91.07 197.37, -43.8 -111.53, 32.85 283.82, 65.98 -73.55, -40.26 in-in in 9.232 Saltbr-in 2.567 HRD-in -63.39, -39.72 55.12, 8.12 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 173.58 APE9-dihe-na 82.9, 175.15 APE8-dihe-in -68.55, 129.72 APE8-rot-in 290.27 APE67-dihe-in -61.35, -40.7 -46.71, -44.32 APE12-dist-in 9.395 APE11-dist-in 11.866 APE10-dist-in 6.463 APE9-dist-in 5.311 None None None XRAY 2.9 0.22 0.258 B 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSC Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.319 13.862 BLAminus DFGAsp-rot-in -132.5, -167.2 53.15, 90.88 197.94, -46.15 -112.82, 31.85 284.73, 65.04 -73.27, -38.01 in-in in 9.284 Saltbr-in 2.688 HRD-in -68.16, -32.65 50.21, 8.96 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.56, 174.55 APE9-dihe-na 83.13, 169.1 APE8-dihe-in -67.01, 134.85 APE8-rot-in 292.8 APE67-dihe-in -59.52, -42.93 -50.35, -45.83 APE12-dist-in 9.371 APE11-dist-in 11.85 APE10-dist-in 6.423 APE9-dist-in 5.142 None None None XRAY 2.9 0.22 0.258 C 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSD Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.814 14.156 BLAminus DFGAsp-rot-in -134.17, -169.15 57.65, 90.27 198.24, -42.24 -112.42, 30.44 284.65, 67.8 -71.85, -40.65 in-in in 9.282 Saltbr-in 2.871 HRD-in -67.33, -33.5 50.97, 9.13 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.48, 173.83 APE9-dihe-na 84.93, 170.2 APE8-dihe-in -68.1, 133.86 APE8-rot-in 288.9 APE67-dihe-in -62.51, -41.81 -51.68, -40.28 APE12-dist-in 9.373 APE11-dist-in 11.857 APE10-dist-in 6.479 APE9-dist-in 5.155 None None None XRAY 2.9 0.22 0.258 D 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSE Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.505 14.264 BLAminus DFGAsp-rot-in -135.58, -169.39 57.54, 90.45 199.95, -43.3 -111.37, 28.44 284.97, 67.41 -69.3, -41.51 in-in in 9.274 Saltbr-in 2.623 HRD-in -64.71, -33.2 48.39, 10.72 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.29, 176.06 APE9-dihe-na 80.99, 170.16 APE8-dihe-in -67.96, 130.54 APE8-rot-in 286.66 APE67-dihe-in -60.14, -42.3 -46.67, -45.24 APE12-dist-in 9.454 APE11-dist-in 11.901 APE10-dist-in 6.481 APE9-dist-in 5.143 None None None XRAY 2.9 0.22 0.258 E 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSF Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.616 14.119 BLAminus DFGAsp-rot-in -134.89, -171.11 59.13, 90.4 195.67, -44.12 -111.83, 30.75 284.9, 68.52 -70.77, -42.22 in-in in 9.252 Saltbr-in 2.717 HRD-in -68.15, -31.91 48.69, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.01, 175.17 APE9-dihe-na 83.79, 172.67 APE8-dihe-in -69.6, 133.37 APE8-rot-in 288.79 APE67-dihe-in -55.11, -42.77 -48.58, -49.06 APE12-dist-in 9.345 APE11-dist-in 11.879 APE10-dist-in 6.468 APE9-dist-in 5.182 None None None XRAY 2.9 0.22 0.258 F 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSG Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.494 14.314 BLAminus DFGAsp-rot-in -135.82, -167.53 53.97, 90.48 199.24, -43.7 -113.32, 35.99 285.56, 66.11 -76.17, -40.16 in-in in 9.308 Saltbr-in 2.761 HRD-in -70.16, -30.04 48.89, 6.41 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.82, 170.5 APE9-dihe-na 87.99, 169.2 APE8-dihe-in -66.17, 133.35 APE8-rot-in 288.2 APE67-dihe-in -59.33, -41.0 -48.7, -47.09 APE12-dist-in 9.465 APE11-dist-in 11.898 APE10-dist-in 6.496 APE9-dist-in 5.212 None None None XRAY 2.9 0.22 0.258 G 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1ZWSH Q9UIK4 12 289 370.0 No_ligand No_ligand Active DFGin 6.27 14.197 BLAminus DFGAsp-rot-in -133.4, -170.17 58.61, 87.07 198.76, -42.5 -108.85, 31.49 285.83, 66.74 -71.93, -40.32 in-in in 9.277 Saltbr-in 2.741 HRD-in -64.8, -35.37 53.61, 6.34 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.03, 173.5 APE9-dihe-na 82.53, 171.84 APE8-dihe-in -65.87, 135.25 APE8-rot-in 288.98 APE67-dihe-in -60.79, -46.0 -54.44, -40.56 APE12-dist-in 9.404 APE11-dist-in 11.849 APE10-dist-in 6.494 APE9-dist-in 5.251 None None None XRAY 2.9 0.22 0.258 H 288 278 0 0 0 0 [[23, 285]] 1.0 1zws CAMK_DAPK2_HUMAN CAMK 2.3e-93 318.2 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1Z9XA Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.816 14.366 BLAminus DFGAsp-rot-in -122.37, 177.57 56.53, 86.55 196.96, -6.5 -100.47, 35.14 283.04, 77.57 -68.13, -25.45 in-in in 9.056 Saltbr-in 2.769 HRD-in -75.07, -45.14 67.51, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.7, -179.11 APE9-dihe-na 83.76, 179.39 APE8-dihe-in -86.47, 121.49 APE8-rot-in 309.23 APE67-dihe-in -48.81, -31.88 -43.95, -49.24 APE12-dist-in 8.92 APE11-dist-in 11.918 APE10-dist-in 6.415 APE9-dist-in 4.86 W315S,S318A None None XRAY 3.93 0.33 0.351 A 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1Z9XB Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.806 14.377 BLAminus DFGAsp-rot-in -121.42, 177.63 56.47, 86.85 197.07, -6.76 -100.52, 34.69 283.29, 77.46 -67.57, -26.04 in-in in 9.067 Saltbr-in 2.764 HRD-in -74.83, -45.4 68.23, 4.11 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, -178.94 APE9-dihe-na 83.9, 179.12 APE8-dihe-in -86.59, 121.31 APE8-rot-in 309.2 APE67-dihe-in -49.13, -32.19 -43.92, -48.8 APE12-dist-in 8.924 APE11-dist-in 11.92 APE10-dist-in 6.411 APE9-dist-in 4.858 W315S,S318A None None XRAY 3.93 0.33 0.351 B 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 1Z9XC Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 7.547 15.118 BLAminus DFGAsp-rot-in -121.58, 177.96 56.36, 86.72 197.17, -6.31 -100.47, 34.43 282.81, 77.57 -67.06, -26.01 in-in in 9.066 Saltbr-in 2.763 HRD-in -75.38, -45.42 68.46, 3.57 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.2, -179.43 APE9-dihe-na 84.44, 179.57 APE8-dihe-in -86.83, 121.87 APE8-rot-in 309.46 APE67-dihe-in -47.91, -32.76 -44.6, -49.36 APE12-dist-in 8.906 APE11-dist-in 11.912 APE10-dist-in 6.407 APE9-dist-in 4.844 W315S,S318A None None XRAY 3.93 0.33 0.351 C 321 303 0 0 0 0 [[23, 285]] 1.0 1z9x CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A2AA Q9UIK4 11 314 370.0 No_ligand No_ligand Active DFGin 6.684 14.383 BLAminus DFGAsp-rot-in -119.69, 176.81 61.75, 81.41 194.63, -8.2 -93.47, 23.98 279.88, 74.53 -64.03, -23.6 in-in in 9.123 Saltbr-in 2.683 HRD-in -79.25, -46.58 67.96, 6.69 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.47, 174.87 APE9-dihe-na 87.2, -175.68 APE8-dihe-in -94.34, 118.35 APE8-rot-in 300.79 APE67-dihe-in -42.19, -35.19 -47.04, -45.86 APE12-dist-in 9.043 APE11-dist-in 11.952 APE10-dist-in 6.521 APE9-dist-in 5.011 None None None XRAY 1.47 0.15 0.207 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A2AB Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.744 14.433 BLAminus DFGAsp-rot-in -122.21, 176.05 67.68, 77.6 195.82, -5.07 -93.12, 25.58 282.77, 69.19 -68.39, -22.13 in-in in 9.205 Saltbr-in 2.677 HRD-in -72.99, -49.0 70.27, 4.72 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.25, 174.69 APE9-dihe-na 93.45, -177.28 APE8-dihe-in -94.41, 118.68 APE8-rot-in 298.27 APE67-dihe-in -43.8, -34.91 -44.15, -50.24 APE12-dist-in 9.252 APE11-dist-in 12.047 APE10-dist-in 6.554 APE9-dist-in 4.958 None None None XRAY 1.47 0.15 0.207 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A2AC Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.674 14.357 BLAminus DFGAsp-rot-in -119.2, 175.64 65.74, 81.62 192.62, -8.58 -92.41, 23.02 284.57, 71.19 -59.72, -25.65 in-in in 9.154 Saltbr-in 2.768 HRD-in -71.23, -46.84 64.68, 10.26 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.68, 178.36 APE9-dihe-na 94.02, -175.35 APE8-dihe-in -101.38, 118.1 APE8-rot-in 296.46 APE67-dihe-in -47.95, -31.42 -44.91, -46.17 APE12-dist-in 9.26 APE11-dist-in 11.995 APE10-dist-in 6.54 APE9-dist-in 4.91 None None None XRAY 1.47 0.15 0.207 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A2AD Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.736 14.315 BLAminus DFGAsp-rot-in -119.82, 176.82 65.08, 80.61 196.38, -9.9 -93.47, 23.05 280.52, 72.68 -60.48, -25.95 in-in in 9.057 Saltbr-in 2.602 HRD-in -77.29, -46.94 69.67, 10.05 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.96, 171.02 APE9-dihe-na 99.63, -176.16 APE8-dihe-in -99.77, 118.11 APE8-rot-in 296.93 APE67-dihe-in -46.19, -31.96 -45.17, -49.15 APE12-dist-in 9.188 APE11-dist-in 11.973 APE10-dist-in 6.51 APE9-dist-in 4.815 None None None XRAY 1.47 0.15 0.207 D 321 303 0 0 0 0 [[23, 285]] 1.0 2a2a CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27A Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.681 14.248 BLAminus DFGAsp-rot-in -127.78, 179.29 58.65, 91.35 192.47, -9.64 -105.91, 29.68 286.17, 76.56 -61.63, -31.63 in-in in 9.384 Saltbr-in 2.881 HRD-in -69.88, -45.14 64.75, 7.97 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.1, 176.23 APE9-dihe-na 94.17, -174.52 APE8-dihe-in -93.98, 123.12 APE8-rot-in 292.41 APE67-dihe-in -50.15, -33.97 -47.47, -45.23 APE12-dist-in 9.062 APE11-dist-in 11.878 APE10-dist-in 6.596 APE9-dist-in 4.938 W315S,S318A None None XRAY 3.0 0.219 0.238 A 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27B Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.612 14.361 BLAminus DFGAsp-rot-in -128.8, 178.95 63.13, 92.86 197.73, -25.0 -105.98, 25.61 284.03, 68.57 -62.5, -24.47 in-in in 9.6 Saltbr-in 2.83 HRD-in -73.11, -45.22 65.39, 7.83 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.32, -179.49 APE9-dihe-na 92.47, -174.21 APE8-dihe-in -101.26, 116.5 APE8-rot-in 291.51 APE67-dihe-in -51.34, -36.73 -43.33, -43.36 APE12-dist-in 8.9 APE11-dist-in 11.847 APE10-dist-in 6.499 APE9-dist-in 4.93 W315S,S318A None None XRAY 3.0 0.219 0.238 B 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27C Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.535 14.276 BLAminus DFGAsp-rot-in -119.58, 179.43 60.32, 93.21 201.76, -12.46 -105.66, 28.61 288.37, 70.21 -56.82, -32.17 in-in in 9.415 Saltbr-in 2.747 HRD-in -64.58, -43.31 62.91, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.57, -173.49 APE9-dihe-na 88.28, -179.86 APE8-dihe-in -91.76, 125.02 APE8-rot-in 294.66 APE67-dihe-in -57.69, -26.01 -51.43, -37.95 APE12-dist-in 8.974 APE11-dist-in 11.934 APE10-dist-in 6.661 APE9-dist-in 5.004 W315S,S318A None None XRAY 3.0 0.219 0.238 C 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27D Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.614 14.274 BLAminus DFGAsp-rot-in -128.72, 173.8 64.24, 85.67 196.83, -2.88 -99.62, 29.31 288.35, 73.41 -61.92, -24.01 in-in in 9.509 Saltbr-in 2.967 HRD-in -61.88, -44.12 64.48, 16.31 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.97, 174.44 APE9-dihe-na 97.7, -173.91 APE8-dihe-in -95.63, 120.09 APE8-rot-in 295.75 APE67-dihe-in -52.82, -41.33 -48.68, -38.8 APE12-dist-in 8.983 APE11-dist-in 11.901 APE10-dist-in 6.604 APE9-dist-in 5.056 W315S,S318A None None XRAY 3.0 0.219 0.238 D 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27E Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.59 14.278 BLAminus DFGAsp-rot-in -127.77, 177.54 62.34, 86.62 196.49, -14.88 -102.34, 30.02 287.41, 74.52 -63.41, -26.85 in-in in 9.495 Saltbr-in 2.971 HRD-in -59.4, -40.6 59.41, 13.5 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.68, 177.19 APE9-dihe-na 98.73, -172.63 APE8-dihe-in -97.09, 127.42 APE8-rot-in 291.88 APE67-dihe-in -54.69, -35.47 -51.42, -39.37 APE12-dist-in 9.007 APE11-dist-in 11.831 APE10-dist-in 6.497 APE9-dist-in 5.032 W315S,S318A None None XRAY 3.0 0.219 0.238 E 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27F Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.562 14.329 BLAminus DFGAsp-rot-in -127.03, 174.44 65.54, 88.72 198.68, -16.28 -104.86, 29.67 286.18, 74.61 -65.35, -24.05 in-in in 9.517 Saltbr-in 3.024 HRD-in -60.92, -43.54 63.95, 5.76 in-in-in SNCiii in-in ActLoopNT-in 3.056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.14, 177.97 APE9-dihe-na 93.1, -173.27 APE8-dihe-in -95.16, 126.31 APE8-rot-in 293.95 APE67-dihe-in -51.6, -34.66 -49.35, -43.58 APE12-dist-in 8.92 APE11-dist-in 11.823 APE10-dist-in 6.493 APE9-dist-in 4.989 W315S,S318A None None XRAY 3.0 0.219 0.238 F 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27G Q9UIK4 12 314 370.0 No_ligand No_ligand Active DFGin 6.607 14.297 BLAminus DFGAsp-rot-in -124.09, 178.3 60.6, 89.92 193.84, -5.63 -103.61, 28.71 285.69, 73.55 -60.18, -29.0 in-in in 9.425 Saltbr-in 2.683 HRD-in -71.81, -39.91 60.98, 9.67 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.99, 177.16 APE9-dihe-na 93.34, -171.63 APE8-dihe-in -96.64, 123.77 APE8-rot-in 295.97 APE67-dihe-in -51.99, -38.48 -50.28, -42.77 APE12-dist-in 8.978 APE11-dist-in 11.913 APE10-dist-in 6.584 APE9-dist-in 4.991 W315S,S318A None None XRAY 3.0 0.219 0.238 G 321 303 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2A27H Q9UIK4 12 315 370.0 No_ligand No_ligand Active DFGin 6.647 14.323 BLAminus DFGAsp-rot-in -123.58, 174.89 63.39, 89.9 195.83, -1.78 -102.17, 30.06 285.48, 73.38 -65.43, -21.82 in-in in 9.448 Saltbr-in 3.19 HRD-in -66.67, -41.82 64.99, 1.08 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.98, -179.93 APE9-dihe-na 94.89, -170.15 APE8-dihe-in -97.76, 127.58 APE8-rot-in 296.2 APE67-dihe-in -52.93, -38.07 -50.7, -43.43 APE12-dist-in 9.044 APE11-dist-in 11.909 APE10-dist-in 6.583 APE9-dist-in 5.025 W315S,S318A None None XRAY 3.0 0.219 0.238 H 321 304 0 0 0 0 [[23, 285]] 1.0 2a27 CAMK_DAPK2_HUMAN CAMK 3.9e-93 317.5 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 6PAWA Q9UIK4 14 329 370.0 No_ligand No_ligand Active DFGin 6.442 14.454 BLAminus DFGAsp-rot-in -122.03, -177.25 57.16, 81.82 195.67, 1.21 -97.53, 30.83 278.66, 75.16 -67.2, -22.6 in-in in 9.418 Saltbr-in 2.627 HRD-in -76.69, -48.31 67.06, 8.69 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.75, -176.65 APE9-dihe-na 82.4, 175.05 APE8-dihe-in -80.56, 124.94 APE8-rot-in 304.27 APE67-dihe-in -61.86, -22.31 -57.54, -31.53 APE12-dist-in 9.008 APE11-dist-in 11.822 APE10-dist-in 6.428 APE9-dist-in 4.793 S318A None None XRAY 2.953 0.251 0.288 A 323 316 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.5e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 6PAWB Q9UIK4 14 329 370.0 No_ligand No_ligand Active DFGin 6.268 14.391 BLAminus DFGAsp-rot-in -124.88, 179.75 58.62, 84.44 193.59, 0.13 -98.1, 27.06 285.38, 66.39 -72.13, -22.89 in-in in 9.696 Saltbr-in 3.39 HRD-in -76.63, -42.55 65.57, 8.55 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.24, -175.02 APE9-dihe-na 83.62, 169.09 APE8-dihe-in -76.77, 128.15 APE8-rot-in 299.79 APE67-dihe-in -59.93, -21.65 -53.61, -36.04 APE12-dist-in 8.841 APE11-dist-in 11.493 APE10-dist-in 6.117 APE9-dist-in 4.821 S318A None None XRAY 2.953 0.251 0.288 B 323 316 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.5e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 6PAWE Q9UIK4 14 318 370.0 No_ligand No_ligand Active DFGin 6.466 14.572 BLAminus DFGAsp-rot-in -116.08, 179.4 58.57, 83.74 193.95, 1.29 -98.92, 25.78 280.98, 73.39 -66.81, -17.19 in-in in 9.605 Saltbr-in 2.825 HRD-in -83.63, -43.25 64.29, 15.45 in-in-in SNCiii in-in ActLoopNT-in 3.233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.5, -175.51 APE9-dihe-na 83.99, 168.94 APE8-dihe-in -78.08, 128.41 APE8-rot-in 292.6 APE67-dihe-in -60.21, -23.76 -55.3, -35.49 APE12-dist-in 9.018 APE11-dist-in 11.914 APE10-dist-in 6.56 APE9-dist-in 4.899 S318A None None XRAY 2.953 0.251 0.288 E 323 305 0 0 0 0 [[23, 285]] 1.0 6paw CAMK_DAPK2_HUMAN CAMK 3.5e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2CKEA Q9UIK4 11 311 370.0 IQU:61302 Type1 Active DFGin 6.687 14.291 BLAminus DFGAsp-rot-in -129.73, 173.26 58.67, 84.81 183.34, 10.48 -97.03, 34.61 290.28, 75.18 -67.91, -24.67 in-in in 9.473 Saltbr-in 3.072 HRD-in -81.88, -47.07 66.79, 11.32 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.73, -175.93 APE9-dihe-na 82.66, 179.11 APE8-dihe-in -92.9, 115.05 APE8-rot-in 304.67 APE67-dihe-in -49.56, -32.91 -37.98, -48.12 APE12-dist-in 8.904 APE11-dist-in 11.732 APE10-dist-in 6.352 APE9-dist-in 4.83 None None None XRAY 2.8 0.206 0.261 A 321 301 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2CKEB Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.665 14.187 BLAminus DFGAsp-rot-in -129.39, 175.97 58.22, 89.64 196.37, -11.24 -106.74, 41.11 290.87, 75.34 -78.74, -13.64 in-in in 9.531 Saltbr-in 2.987 HRD-in -79.93, -46.41 62.29, 15.38 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.79, 172.99 APE9-dihe-na 95.73, 174.88 APE8-dihe-in -90.25, 115.25 APE8-rot-in 312.17 APE67-dihe-in -52.78, -31.46 -41.53, -38.53 APE12-dist-in 8.726 APE11-dist-in 11.712 APE10-dist-in 6.407 APE9-dist-in 5.041 None None None XRAY 2.8 0.206 0.261 B 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2CKEC Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.62 14.19 BLAminus DFGAsp-rot-in -124.69, 173.31 66.47, 87.12 193.89, -26.11 -105.4, 35.82 287.2, 74.68 -74.65, -17.2 in-in in 9.397 Saltbr-in 3.245 HRD-in -80.55, -43.97 65.13, 16.98 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.99, 174.7 APE9-dihe-na 88.24, 173.59 APE8-dihe-in -80.52, 122.26 APE8-rot-in 299.81 APE67-dihe-in -51.42, -30.04 -42.33, -47.48 APE12-dist-in 8.922 APE11-dist-in 11.761 APE10-dist-in 6.395 APE9-dist-in 4.982 None None None XRAY 2.8 0.206 0.261 C 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_HUMAN 2CKED Q9UIK4 12 311 370.0 IQU:61302 Type1 Active DFGin 6.654 14.203 BLAminus DFGAsp-rot-in -124.44, -179.32 54.35, 92.57 199.02, -15.93 -105.67, 31.58 285.28, 75.86 -69.96, -19.93 in-in in 9.238 Saltbr-in 2.624 HRD-in -86.03, -41.35 62.45, 5.47 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, -177.67 APE9-dihe-na 85.99, 174.33 APE8-dihe-in -91.52, 115.64 APE8-rot-in 307.04 APE67-dihe-in -50.72, -29.31 -39.85, -44.61 APE12-dist-in 8.878 APE11-dist-in 11.768 APE10-dist-in 6.342 APE9-dist-in 4.801 None None None XRAY 2.8 0.206 0.261 D 321 300 0 0 0 0 [[23, 285]] 1.0 2cke CAMK_DAPK2_HUMAN CAMK 3.4e-93 317.7 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK3 DAPK3_HUMAN AF-O43293-K1A O43293 5 283 454.0 No_ligand No_ligand Active DFGin 6.748 14.044 BLAminus DFGAsp-rot-in -123.35, 175.18 57.14, 85.1 200.46, 17.58 -91.34, 18.19 285.15, 81.66 -60.32, -31.25 in-in in 9.234 Saltbr-in 2.745 HRD-in -73.32, -40.76 62.86, -13.13 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.45, -179.33 APE9-dihe-na 83.48, 171.43 APE8-dihe-in -83.74, 124.14 APE8-rot-in 298.87 APE67-dihe-in -61.76, -27.25 -48.42, -36.53 APE12-dist-in 8.761 APE11-dist-in 11.759 APE10-dist-in 6.301 APE9-dist-in 5.093 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[13, 275]] 1.0 AF-O43293-K1 CAMK_DAPK3_HUMAN CAMK 9.1e-97 329.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN AF-O43293-K3A O43293 5 283 454.0 No_ligand No_ligand Active DFGin 6.714 14.117 BLAminus DFGAsp-rot-in -125.53, -178.47 52.36, 75.24 203.17, 14.25 -81.75, 15.99 283.01, 81.08 -55.71, -32.68 in-in in 9.322 Saltbr-in 2.723 HRD-in -78.84, -39.96 62.42, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.11, -174.39 APE9-dihe-na 82.83, 170.05 APE8-dihe-in -79.78, 124.91 APE8-rot-in 299.59 APE67-dihe-in -71.44, -29.01 -52.73, -26.14 APE12-dist-in 8.595 APE11-dist-in 11.809 APE10-dist-in 6.327 APE9-dist-in 4.712 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[13, 275]] 1.0 AF-O43293-K3 CAMK_DAPK3_HUMAN CAMK 9.1e-97 329.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 1YRPA O43293 2 277 454.0 No_ligand No_ligand Active DFGin 6.736 13.755 BLAminus DFGAsp-rot-in -134.53, 168.02 67.46, 101.36 192.88, 6.01 -121.14, 21.48 292.51, 79.87 -63.71, -8.91 in-in in 9.21 Saltbr-in 2.51 HRD-in -63.58, -46.12 71.02, -4.0 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.45, 166.65 APE9-dihe-na 98.49, -177.72 APE8-dihe-in -92.21, 127.08 APE8-rot-in 307.54 APE67-dihe-in -53.2, -35.86 -39.66, -46.71 APE12-dist-in 9.541 APE11-dist-in 11.338 APE10-dist-in 5.81 APE9-dist-in 4.578 None TPO265 TPO265 XRAY 3.1 0.245 0.268 A 278 276 0 0 0 0 [[13, 275]] 1.0 1yrp CAMK_DAPK3_HUMAN CAMK 9e-97 329.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 1YRPB O43293 2 277 454.0 No_ligand No_ligand Active DFGin 6.74 13.77 BLAminus DFGAsp-rot-in -134.26, 167.85 67.06, 101.54 193.48, 7.25 -121.73, 22.3 292.45, 80.16 -64.33, -8.63 in-in in 9.222 Saltbr-in 2.53 HRD-in -63.83, -45.65 70.82, -3.89 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.85, 166.44 APE9-dihe-na 98.86, -176.99 APE8-dihe-in -92.88, 126.22 APE8-rot-in 307.9 APE67-dihe-in -54.47, -35.24 -39.85, -44.93 APE12-dist-in 9.543 APE11-dist-in 11.336 APE10-dist-in 5.806 APE9-dist-in 4.562 None TPO265 TPO265 XRAY 3.1 0.245 0.268 B 278 276 0 0 0 0 [[13, 275]] 1.0 1yrp CAMK_DAPK3_HUMAN CAMK 9e-97 329.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 5VJAA O43293 9 277 454.0 DUK:61002 Type1 Active DFGin 6.921 14.411 BLAminus DFGAsp-rot-in -124.21, 167.93 69.15, 85.7 191.59, -0.68 -98.82, 31.64 285.89, 72.01 -66.28, -27.84 in-in in 9.184 Saltbr-in 2.753 HRD-in -75.5, -47.39 68.94, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.18, 178.74 APE9-dihe-na 90.02, -176.89 APE8-dihe-in -101.23, 120.34 APE8-rot-in 301.7 APE67-dihe-in -45.29, -32.43 -40.42, -52.96 APE12-dist-in 8.543 APE11-dist-in 11.913 APE10-dist-in 6.514 APE9-dist-in 4.479 None None None XRAY 2.46 0.19 0.237 A 283 264 5 0 0 0 [[13, 275]] 1.0 5vja CAMK_DAPK3_HUMAN CAMK 9.7e-97 329.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 5VJAB O43293 9 278 454.0 DUK:61002 Type1 Active DFGin 6.902 14.428 BLAminus DFGAsp-rot-in -123.57, 168.82 69.53, 85.85 190.95, -0.59 -99.43, 30.94 286.28, 72.91 -67.68, -26.05 in-in in 9.22 Saltbr-in 2.735 HRD-in -75.95, -47.94 69.17, 0.43 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.45, 178.52 APE9-dihe-na 89.96, -176.86 APE8-dihe-in -102.13, 121.23 APE8-rot-in 300.73 APE67-dihe-in -45.57, -32.05 -40.27, -53.64 APE12-dist-in 8.541 APE11-dist-in 11.916 APE10-dist-in 6.514 APE9-dist-in 4.478 None None None XRAY 2.46 0.19 0.237 B 283 264 6 0 0 0 [[13, 275]] 1.0 5vja CAMK_DAPK3_HUMAN CAMK 9.7e-97 329.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 5VJAC O43293 9 278 454.0 DUK:61002 Type1 Active DFGin 6.978 14.47 BLAminus DFGAsp-rot-in -125.79, 169.08 71.44, 84.47 191.49, -3.76 -99.06, 30.82 287.63, 73.32 -66.0, -28.44 in-in in 9.402 Saltbr-in 2.709 HRD-in -73.9, -47.63 70.4, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 177.52 APE9-dihe-na 90.76, -176.28 APE8-dihe-in -101.02, 120.52 APE8-rot-in 301.36 APE67-dihe-in -45.99, -31.65 -41.76, -53.26 APE12-dist-in 8.552 APE11-dist-in 11.944 APE10-dist-in 6.513 APE9-dist-in 4.42 None None None XRAY 2.46 0.19 0.237 C 283 263 7 0 0 0 [[13, 275]] 1.0 5vja CAMK_DAPK3_HUMAN CAMK 9.7e-97 329.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 5VJAD O43293 9 277 454.0 DUK:60303 Type1 Active DFGin 6.978 14.446 BLAminus DFGAsp-rot-in -125.49, 168.91 71.14, 84.23 192.55, -3.96 -98.06, 29.74 287.71, 73.43 -66.47, -27.82 in-in in 9.402 Saltbr-in 2.687 HRD-in -74.02, -47.37 69.6, -1.17 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.18, 177.87 APE9-dihe-na 90.89, -176.29 APE8-dihe-in -102.1, 120.9 APE8-rot-in 302.0 APE67-dihe-in -48.83, -30.37 -39.86, -53.06 APE12-dist-in 8.564 APE11-dist-in 11.96 APE10-dist-in 6.524 APE9-dist-in 4.457 None None None XRAY 2.46 0.19 0.237 D 283 259 10 0 0 0 [[13, 275]] 1.0 5vja CAMK_DAPK3_HUMAN CAMK 9.7e-97 329.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DCLK1 DCLK1_HUMAN 5JZJA O15075 374 648 740.0 AN2:703 ATPlike Active DFGin 6.559 14.457 BLAminus DFGAsp-rot-in -124.73, -164.54 49.76, 81.39 192.06, -9.31 -91.62, 27.77 280.9, 72.89 -62.64, -30.24 in-in in 9.264 Saltbr-in 2.961 HRD-in -80.29, -46.18 67.47, 2.65 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.12, 159.65 APE9-dihe-na 123.02, -170.92 APE8-dihe-in -106.5, 129.13 APE8-rot-in 307.92 APE67-dihe-in -61.41, -36.29 -48.5, -40.56 APE12-dist-in 8.952 APE11-dist-in 12.325 APE10-dist-in 6.742 APE9-dist-in 4.306 None None None XRAY 1.71 0.178 0.208 A 297 271 4 0 0 0 [[390, 647]] 1.0 5jzj CAMK_DCLK1_HUMAN CAMK 7.8e-90 306.6 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 5JZJB O15075 382 648 740.0 AN2:902 ATPlike Active DFGin 6.403 14.423 BLAminus DFGAsp-rot-in -126.14, -167.19 53.32, 81.81 194.93, -13.29 -94.99, 26.92 281.83, 75.21 -56.86, -35.14 in-in in 8.806 Saltbr-in 2.638 HRD-in -80.6, -45.11 67.98, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.06, 162.17 APE9-dihe-na 120.91, -173.72 APE8-dihe-in -109.44, 126.03 APE8-rot-in 300.86 APE67-dihe-in -59.98, -31.53 -43.43, -44.7 APE12-dist-in 9.044 APE11-dist-in 12.358 APE10-dist-in 6.832 APE9-dist-in 4.274 None None None XRAY 1.71 0.178 0.208 B 297 261 6 0 0 0 [[390, 647]] 1.0 5jzj CAMK_DCLK1_HUMAN CAMK 7.8e-90 306.6 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN AF-O15075-K1A O15075 382 655 740.0 No_ligand No_ligand Active DFGin 6.71 14.136 BLAminus DFGAsp-rot-in -123.43, -177.54 55.13, 83.63 198.02, 26.03 -89.59, 18.76 286.7, 78.81 -61.98, -24.84 in-in in 9.376 Saltbr-in 2.656 HRD-in -82.62, -43.78 68.07, -8.41 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.64, 176.18 APE9-dihe-na 95.2, 172.02 APE8-dihe-in -84.37, 130.95 APE8-rot-in 301.46 APE67-dihe-in -66.0, -26.72 -49.86, -39.62 APE12-dist-in 8.915 APE11-dist-in 12.005 APE10-dist-in 6.381 APE9-dist-in 3.439 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[390, 647]] 1.0 AF-O15075-K1 CAMK_DCLK1_HUMAN CAMK 5.8e-90 307.0 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN AF-O15075-K3A O15075 382 655 740.0 No_ligand No_ligand Active DFGin 6.28 14.253 BLAminus DFGAsp-rot-in -122.96, -171.69 45.86, 83.73 201.28, 18.15 -86.22, 18.62 285.46, 79.64 -60.22, -25.19 in-in in 9.386 Saltbr-in 2.601 HRD-in -85.33, -43.31 66.9, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.15, 177.78 APE9-dihe-na 95.45, -177.27 APE8-dihe-in -95.75, 121.28 APE8-rot-in 300.22 APE67-dihe-in -61.23, -25.17 -42.05, -45.93 APE12-dist-in 8.988 APE11-dist-in 11.972 APE10-dist-in 6.369 APE9-dist-in 3.348 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[390, 647]] 1.0 AF-O15075-K3 CAMK_DCLK1_HUMAN CAMK 5.8e-90 307.0 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 5JZNA O15075 379 648 740.0 GUI:701 Type1 Active DFGin 6.404 14.509 BLAminus DFGAsp-rot-in -125.42, -165.27 48.91, 82.22 192.43, -81.71 -91.62, 28.76 281.24, 72.51 -61.94, -30.05 in-in in 8.973 Saltbr-in 3.096 HRD-in -79.96, -46.23 67.3, 2.72 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.84, 160.64 APE9-dihe-na 123.28, -170.71 APE8-dihe-in -105.56, 128.85 APE8-rot-in 303.98 APE67-dihe-in -62.18, -35.69 -48.05, -41.12 APE12-dist-in 8.873 APE11-dist-in 12.173 APE10-dist-in 6.649 APE9-dist-in 4.283 None None None XRAY 2.85 0.183 0.225 A 280 268 2 0 0 0 [[390, 647]] 1.0 5jzn CAMK_DCLK1_HUMAN CAMK 6.3e-90 306.9 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 5JZNB O15075 380 648 740.0 GUI:701 Type1 Active DFGin 6.649 14.736 BLAminus DFGAsp-rot-in -125.38, -165.81 48.37, 82.76 192.41, -78.78 -91.87, 28.76 282.5, 73.21 -61.79, -29.61 in-in in 9.143 Saltbr-in 3.046 HRD-in -80.35, -46.23 67.17, 3.18 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.87, 160.33 APE9-dihe-na 123.29, -171.62 APE8-dihe-in -106.44, 128.21 APE8-rot-in 306.11 APE67-dihe-in -61.96, -35.8 -48.32, -41.43 APE12-dist-in 9.087 APE11-dist-in 12.317 APE10-dist-in 6.854 APE9-dist-in 4.321 None None None XRAY 2.85 0.183 0.225 B 280 266 3 0 0 0 [[390, 647]] 1.0 5jzn CAMK_DCLK1_HUMAN CAMK 6.3e-90 306.9 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 7KX6A O15075 381 648 740.0 X7Y:701 Type1 Active DFGin 6.779 14.543 BLAminus DFGAsp-rot-in -132.14, -171.67 60.36, 84.2 198.54, -11.1 -97.39, 25.55 288.29, 70.39 -61.56, -27.81 in-in in 9.912 Saltbr-in 2.896 HRD-in -75.26, -50.25 71.96, 3.88 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.6, 173.01 APE9-dihe-na 94.5, 166.65 APE8-dihe-in -81.98, 129.71 APE8-rot-in 302.52 APE67-dihe-in -56.44, -32.82 -54.39, -33.85 APE12-dist-in 9.427 APE11-dist-in 12.089 APE10-dist-in 6.618 APE9-dist-in 3.772 None None None XRAY 2.5 0.194 0.225 A 280 258 10 0 0 0 [[390, 647]] 1.0 7kx6 CAMK_DCLK1_HUMAN CAMK 6.3e-90 306.9 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 7KX6B O15075 382 648 740.0 X7Y:701 Type1 Active DFGin 6.581 14.651 BLAminus DFGAsp-rot-in -131.86, -170.65 61.64, 82.65 199.67, -10.67 -97.25, 26.78 285.98, 67.7 -61.39, -28.88 in-in in 9.087 Saltbr-in 2.787 HRD-in -76.82, -50.64 71.53, 5.36 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 172.12 APE9-dihe-na 93.65, 169.11 APE8-dihe-in -80.93, 129.15 APE8-rot-in 301.85 APE67-dihe-in -56.14, -33.85 -55.67, -32.58 APE12-dist-in 9.149 APE11-dist-in 11.984 APE10-dist-in 6.543 APE9-dist-in 3.885 None None None XRAY 2.5 0.194 0.225 B 280 254 13 0 0 0 [[390, 647]] 1.0 7kx6 CAMK_DCLK1_HUMAN CAMK 6.3e-90 306.9 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 7F3GA O15075 376 648 740.0 RXT:701 Type1 Active DFGin 6.674 14.379 BLAminus DFGAsp-rot-in -131.42, -164.35 50.73, 76.39 199.85, -7.22 -91.35, 23.05 284.75, 76.39 -54.91, -40.4 in-in in 8.723 Saltbr-in 2.679 HRD-in -76.96, -53.39 78.05, 3.73 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.25, 161.47 APE9-dihe-na 117.41, -174.72 APE8-dihe-in -98.2, 123.83 APE8-rot-in 304.21 APE67-dihe-in -51.76, -35.68 -44.27, -44.97 APE12-dist-in 8.951 APE11-dist-in 12.299 APE10-dist-in 6.676 APE9-dist-in 3.964 None None None XRAY 2.1 0.213 0.253 A 282 273 0 0 0 0 [[390, 647]] 1.0 7f3g CAMK_DCLK1_HUMAN CAMK 6.5e-90 306.9 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 7KX8A O15075 382 669 740.0 X8J:60701 Type1 Active DFGin 6.806 14.536 BLAminus DFGAsp-rot-in -141.52, -173.15 56.26, 82.66 204.31, -44.3 -95.92, 27.6 281.91, 67.63 -63.91, -34.07 in-in in 9.77 Saltbr-in 2.415 HRD-in -71.02, -45.04 65.43, 2.41 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.78, 156.27 APE9-dihe-na 105.12, 163.78 APE8-dihe-in -71.62, 134.03 APE8-rot-in 296.55 APE67-dihe-in -60.97, -39.76 -60.38, -24.01 APE12-dist-in 9.363 APE11-dist-in 12.059 APE10-dist-in 6.415 APE9-dist-in 3.81 None None None XRAY 3.1 0.196 0.251 A 317 263 17 0 0 0 [[390, 647]] 1.0 7kx8 CAMK_DCLK1_HUMAN CAMK 9.9e-90 306.3 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK1 DCLK1_HUMAN 7KX8B O15075 380 647 740.0 X8J:60701 Type1 Active DFGin 6.669 14.75 BLAminus DFGAsp-rot-in -142.11, -173.28 56.23, 82.57 205.64, -42.45 -95.17, 29.17 282.77, 69.4 -64.42, -34.42 in-in in 8.945 Saltbr-in 3.084 HRD-in -69.7, -44.66 66.71, 3.36 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.36, 159.42 APE9-dihe-na 106.41, 164.71 APE8-dihe-in -71.34, 134.95 APE8-rot-in 297.75 APE67-dihe-in -62.8, -40.01 -62.08, -25.45 APE12-dist-in 9.514 APE11-dist-in 12.154 APE10-dist-in 6.532 APE9-dist-in 4.012 None None None XRAY 3.1 0.196 0.251 B 317 251 17 0 0 0 [[390, 647]] 1.0 7kx8 CAMK_DCLK1_HUMAN CAMK 9.9e-90 306.3 1 256 256 532 533 534 536 538 419 436 440 508 510 509 511 569 557 552 551 550 549 548 547 546 466 Serine/threonine-protein kinase DCLK1
CAMK DCLK2 DCLK2_HUMAN AF-Q8N568-K1A Q8N568 386 659 766.0 No_ligand No_ligand Active DFGin 6.784 14.266 BLAminus DFGAsp-rot-in -125.1, -174.9 54.55, 83.84 193.18, 18.39 -92.46, 16.94 286.15, 78.72 -60.66, -24.1 in-in in 9.519 Saltbr-in 2.657 HRD-in -82.08, -41.98 67.42, -12.08 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.75, 175.16 APE9-dihe-na 94.93, 167.76 APE8-dihe-in -77.13, 129.48 APE8-rot-in 302.18 APE67-dihe-in -67.63, -25.61 -50.82, -38.24 APE12-dist-in 9.036 APE11-dist-in 12.06 APE10-dist-in 6.432 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[394, 651]] 1.0 AF-Q8N568-K1 CAMK_DCLK2_HUMAN CAMK 5.2e-89 303.9 1 256 256 536 537 538 540 542 423 440 444 512 514 513 515 573 561 556 555 554 553 552 551 550 470 Serine/threonine-protein kinase DCLK2
CAMK DCLK2 DCLK2_HUMAN AF-Q8N568-K3A Q8N568 386 659 766.0 No_ligand No_ligand Active DFGin 6.359 14.399 BLAminus DFGAsp-rot-in -123.34, -172.04 48.44, 84.64 196.13, 7.16 -88.74, 16.35 285.56, 80.6 -59.5, -23.58 in-in in 9.467 Saltbr-in 2.634 HRD-in -85.15, -42.02 66.24, -5.8 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.82, 175.38 APE9-dihe-na 95.24, 171.22 APE8-dihe-in -75.84, 123.71 APE8-rot-in 290.51 APE67-dihe-in -62.42, -26.28 -43.16, -42.98 APE12-dist-in 8.989 APE11-dist-in 12.009 APE10-dist-in 6.376 APE9-dist-in 3.437 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[394, 651]] 1.0 AF-Q8N568-K3 CAMK_DCLK2_HUMAN CAMK 5.2e-89 303.9 1 256 256 536 537 538 540 542 423 440 444 512 514 513 515 573 561 556 555 554 553 552 551 550 470 Serine/threonine-protein kinase DCLK2
CAMK DCLK3 DCLK3_HUMAN AF-Q9C098-K1A Q9C098 348 621 648.0 No_ligand No_ligand Active DFGin 5.944 13.572 BLAminus DFGAsp-rot-in -131.34, 173.96 56.51, 85.16 197.35, 26.38 -92.7, 17.03 297.21, 90.82 -61.53, -22.98 in-in in 9.414 Saltbr-in 2.679 HRD-in -78.54, -46.32 66.53, -6.83 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.64, 173.41 APE9-dihe-na 100.34, 169.71 APE8-dihe-in -78.57, 126.85 APE8-rot-in 300.98 APE67-dihe-in -69.12, -25.54 -48.55, -35.79 APE12-dist-in 8.999 APE11-dist-in 12.084 APE10-dist-in 6.49 APE9-dist-in 3.48 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[356, 613]] 1.0 AF-Q9C098-K1 CAMK_DCLK3_HUMAN CAMK 8.6e-92 313.0 1 256 256 498 499 500 502 504 385 402 406 474 476 475 477 535 523 518 517 516 515 514 513 512 432 Serine/threonine-protein kinase DCLK3
CAMK DCLK3 DCLK3_HUMAN AF-Q9C098-K3A Q9C098 348 621 648.0 No_ligand No_ligand Active DFGin 5.609 13.675 BLAminus DFGAsp-rot-in -132.85, 177.21 53.63, 77.36 200.18, 21.58 -83.29, 15.26 296.76, 89.48 -61.64, -17.6 in-in in 9.392 Saltbr-in 2.67 HRD-in -81.07, -46.31 68.74, -2.36 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.81, 177.66 APE9-dihe-na 95.33, 177.08 APE8-dihe-in -88.25, 121.35 APE8-rot-in 301.01 APE67-dihe-in -64.5, -25.44 -40.63, -45.42 APE12-dist-in 9.159 APE11-dist-in 11.965 APE10-dist-in 6.385 APE9-dist-in 3.487 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[356, 613]] 1.0 AF-Q9C098-K3 CAMK_DCLK3_HUMAN CAMK 8.6e-92 313.0 1 256 256 498 499 500 502 504 385 402 406 474 476 475 477 535 523 518 517 516 515 514 513 512 432 Serine/threonine-protein kinase DCLK3
CAMK HUNK HUNK_HUMAN AF-P57058-K3A P57058 54 328 714.0 No_ligand No_ligand Active DFGin 5.759 14.366 BLAminus DFGAsp-rot-in -125.67, 176.88 62.63, 72.25 206.09, 9.26 -80.85, 11.76 286.4, 76.04 -59.32, -29.53 in-in in 9.204 Saltbr-in 2.71 HRD-in -76.8, -45.56 67.78, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.1, 173.54 APE9-dihe-na 88.08, 170.17 APE8-dihe-in -73.58, 125.26 APE8-rot-in 290.52 APE67-dihe-in -67.36, -21.19 -54.65, -34.56 APE12-dist-in 8.836 APE11-dist-in 11.472 APE10-dist-in 5.884 APE9-dist-in 3.722 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[61, 320]] 1.0 AF-P57058-K3 CAMK_HUNK_HUMAN CAMK 2.4e-81 278.8 5 256 252 203 204 205 207 209 91 111 115 183 185 184 186 245 233 228 227 226 225 224 223 222 141 Hormonally up-regulated neu tumor-associated kinase
CAMK KALRN KALRN_HUMAN AF-O60229-K1A O60229 2675 2945 2986.0 No_ligand No_ligand Active DFGin 5.803 12.713 BLAminus DFGAsp-rot-in -124.0, 171.86 64.31, 66.44 209.74, 9.42 -78.88, 25.85 299.18, 178.45 -62.12, -42.39 in-in in 8.903 Saltbr-in 2.708 HRD-in -79.75, -40.97 63.59, 6.57 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -87.28, 143.63 APE9-dihe-na 68.24, -150.22 APE8-dihe-in -91.01, 124.17 APE8-rot-na 181.51 APE67-dihe-in -66.63, -26.57 -50.33, -35.47 APE12-dist-in 10.367 APE11-dist-in 12.153 APE10-dist-in 6.138 APE9-dist-in 5.994 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[2684, 2938]] 1.0 AF-O60229-K1 CAMK_KALRN_HUMAN CAMK 3.4e-80 275.0 1 256 256 2823 2824 2825 2827 2829 2713 2728 2732 2800 2802 2801 2803 2862 2850 2845 2844 2843 2842 2841 2840 2839 2758 Kalirin
CAMK KALRN KALRN_HUMAN AF-O60229-K3A O60229 2675 2945 2986.0 No_ligand No_ligand Active DFGin 5.954 12.603 BLAminus DFGAsp-rot-in -125.87, 174.68 61.11, 59.84 206.67, 21.28 -74.1, 25.62 301.26, 4.77 -68.95, -31.59 in-in in 8.501 Saltbr-in 2.78 HRD-in -81.95, -43.19 69.02, 4.15 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -95.18, 145.57 APE9-dihe-na 72.55, 173.65 APE8-dihe-in -77.07, 123.43 APE8-rot-na 180.07 APE67-dihe-in -65.47, -34.89 -57.11, -23.0 APE12-dist-in 13.114 APE11-dist-in 11.259 APE10-dist-in 6.025 APE9-dist-in 4.251 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[2684, 2938]] 1.0 AF-O60229-K3 CAMK_KALRN_HUMAN CAMK 3.4e-80 275.0 1 256 256 2823 2824 2825 2827 2829 2713 2728 2732 2800 2802 2801 2803 2862 2850 2845 2844 2843 2842 2841 2840 2839 2758 Kalirin
CAMK MAPKAPK2 MAPK2_HUMAN AF-P49137-K1A P49137 55 333 400.0 No_ligand No_ligand Active DFGin 4.546 13.824 BLAminus DFGAsp-rot-in -134.44, -178.32 60.99, 73.02 205.65, 12.07 -77.16, 14.94 284.91, 72.06 -61.19, -19.08 in-in in 9.222 Saltbr-in 2.655 HRD-in -73.97, -44.93 66.36, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.85, 117.34 APE9-dihe-na -163.87, 158.43 APE8-dihe-in -103.05, 128.91 APE8-rot-in 302.59 APE67-dihe-in -76.17, -21.81 -42.87, -45.53 APE12-dist-in 8.406 APE11-dist-in 10.793 APE10-dist-in 5.107 APE9-dist-in 4.569 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K1 CAMK_MAPKAPK2_HUMAN CAMK 2.1e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN AF-P49137-K3A P49137 55 333 400.0 No_ligand No_ligand Active DFGin 4.263 13.854 BLAminus DFGAsp-rot-in -139.32, -176.01 59.17, 72.48 205.77, -6.16 -74.28, 14.66 284.7, 72.91 -60.93, -20.2 in-in in 9.302 Saltbr-in 2.682 HRD-in -78.07, -45.55 66.87, 7.53 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 122.38 APE9-dihe-na -167.75, 155.99 APE8-dihe-in -92.86, 129.83 APE8-rot-in 298.63 APE67-dihe-in -72.76, -25.18 -45.14, -45.86 APE12-dist-in 8.677 APE11-dist-in 11.15 APE10-dist-in 5.293 APE9-dist-in 4.364 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K3 CAMK_MAPKAPK2_HUMAN CAMK 2.1e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK3 MAPK3_HUMAN AF-Q16644-K3A Q16644 35 312 382.0 No_ligand No_ligand Active DFGin 4.453 13.771 BLAminus DFGAsp-rot-in -141.13, -173.98 60.0, 69.22 200.46, 8.06 -73.03, 15.18 289.25, 77.08 -61.22, -21.39 in-in in 9.051 Saltbr-in 2.651 HRD-in -75.91, -41.53 65.33, 2.81 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.16, 120.25 APE9-dihe-na -163.18, 151.85 APE8-dihe-in -89.84, 127.11 APE8-rot-in 294.68 APE67-dihe-in -72.74, -26.46 -44.11, -46.25 APE12-dist-in 8.673 APE11-dist-in 11.491 APE10-dist-in 5.666 APE9-dist-in 4.467 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[43, 304]] 1.0 AF-Q16644-K3 CAMK_MAPKAPK3_HUMAN CAMK 4e-79 271.5 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK5 MAPK5_HUMAN AF-Q8IW41-K1A Q8IW41 12 312 473.0 No_ligand No_ligand Active DFGin 4.858 14.273 BLAminus DFGAsp-rot-in -136.15, -176.48 59.97, 66.87 200.35, 25.57 -74.84, 19.36 285.74, 73.66 -63.23, -23.81 in-in in 9.271 Saltbr-in 2.633 HRD-in -73.8, -45.61 67.27, 0.49 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.45, 130.27 APE9-dihe-na -173.36, 159.64 APE8-dihe-in -94.13, 130.73 APE8-rot-in 296.92 APE67-dihe-in -77.33, -19.46 -42.58, -42.94 APE12-dist-in 8.942 APE11-dist-in 10.758 APE10-dist-in 4.948 APE9-dist-in 3.906 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[20, 304]] 1.0 AF-Q8IW41-K1 CAMK_MAPKAPK5_HUMAN CAMK 1.7e-74 256.8 4 256 253 168 169 170 172 174 51 62 66 145 147 146 148 223 193 188 187 186 185 184 183 182 103 MAP kinase-activated protein kinase 5
CAMK MAPKAPK5 MAPK5_HUMAN AF-Q8IW41-K3A Q8IW41 12 312 473.0 No_ligand No_ligand Active DFGin 4.359 14.012 BLAminus DFGAsp-rot-in -138.6, -179.1 58.37, 70.01 203.37, -0.56 -72.14, 18.16 289.5, 76.47 -62.51, -22.52 in-in in 9.21 Saltbr-in 2.652 HRD-in -76.74, -44.44 66.72, -0.65 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.72, 128.68 APE9-dihe-na -167.95, 162.68 APE8-dihe-in -95.84, 128.46 APE8-rot-in 298.56 APE67-dihe-in -77.33, -26.52 -44.21, -45.84 APE12-dist-in 8.189 APE11-dist-in 11.325 APE10-dist-in 5.612 APE9-dist-in 4.347 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[20, 304]] 1.0 AF-Q8IW41-K3 CAMK_MAPKAPK5_HUMAN CAMK 1.7e-74 256.8 4 256 253 168 169 170 172 174 51 62 66 145 147 146 148 223 193 188 187 186 185 184 183 182 103 MAP kinase-activated protein kinase 5
CAMK MARK1 MARK1_HUMAN AF-Q9P0L2-K1A Q9P0L2 52 319 795.0 No_ligand No_ligand Active DFGin 6.625 14.547 BLAminus DFGAsp-rot-in -122.98, 175.78 56.96, 74.47 199.41, 29.49 -82.32, 16.31 287.99, 81.42 -61.89, -29.97 in-in in 9.419 Saltbr-in 2.672 HRD-in -80.47, -47.8 64.59, 7.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.37, 160.03 APE9-dihe-na 92.74, 171.97 APE8-dihe-in -71.38, 130.98 APE8-rot-in 280.72 APE67-dihe-in -65.29, -22.67 -52.54, -38.97 APE12-dist-in 8.628 APE11-dist-in 10.932 APE10-dist-in 5.135 APE9-dist-in 3.448 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K1 CAMK_MARK1_HUMAN CAMK 4.7e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
CAMK MARK1 MARK1_HUMAN AF-Q9P0L2-K3A Q9P0L2 52 319 795.0 No_ligand No_ligand Active DFGin 6.299 14.455 BLAminus DFGAsp-rot-in -124.46, 174.9 53.8, 76.93 200.14, 4.12 -79.51, 14.6 286.75, 85.5 -59.82, -27.14 in-in in 9.352 Saltbr-in 2.668 HRD-in -83.94, -45.21 65.05, -3.0 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.32, -179.8 APE9-dihe-na 99.63, 167.85 APE8-dihe-in -79.1, 124.28 APE8-rot-in 299.06 APE67-dihe-in -64.9, -22.13 -51.43, -39.55 APE12-dist-in 8.264 APE11-dist-in 11.214 APE10-dist-in 5.7 APE9-dist-in 3.223 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[60, 311]] 1.0 AF-Q9P0L2-K3 CAMK_MARK1_HUMAN CAMK 4.7e-97 330.3 1 256 256 199 200 201 203 205 89 107 111 179 181 180 182 239 226 221 220 219 218 217 216 215 137 Serine/threonine-protein kinase MARK1
CAMK MARK2 MARK2_HUMAN AF-Q7KZI7-K1A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.617 14.459 BLAminus DFGAsp-rot-in -124.25, 176.28 57.12, 73.23 200.99, 30.95 -81.85, 16.44 288.16, 80.98 -61.95, -29.5 in-in in 9.397 Saltbr-in 2.678 HRD-in -79.11, -48.82 65.67, 0.61 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.73, 161.68 APE9-dihe-na 92.79, 171.11 APE8-dihe-in -68.76, 130.08 APE8-rot-in 283.89 APE67-dihe-in -65.41, -22.04 -52.41, -39.4 APE12-dist-in 8.61 APE11-dist-in 10.941 APE10-dist-in 5.135 APE9-dist-in 3.493 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[53, 304]] 1.0 AF-Q7KZI7-K1 CAMK_MARK2_HUMAN CAMK 4.7e-97 330.3 1 256 256 192 193 194 196 198 82 100 104 172 174 173 175 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK2 MARK2_HUMAN AF-Q7KZI7-K3A Q7KZI7 45 312 788.0 No_ligand No_ligand Active DFGin 6.334 14.463 BLAminus DFGAsp-rot-in -124.9, 174.85 53.99, 75.54 200.51, 12.2 -78.47, 15.52 286.14, 85.13 -59.73, -27.22 in-in in 9.377 Saltbr-in 2.681 HRD-in -85.93, -45.9 63.51, 12.19 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.31, 179.02 APE9-dihe-na 100.33, 167.6 APE8-dihe-in -78.21, 124.32 APE8-rot-in 298.84 APE67-dihe-in -65.56, -21.76 -51.27, -39.62 APE12-dist-in 8.23 APE11-dist-in 11.191 APE10-dist-in 5.68 APE9-dist-in 3.255 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[53, 304]] 1.0 AF-Q7KZI7-K3 CAMK_MARK2_HUMAN CAMK 4.7e-97 330.3 1 256 256 192 193 194 196 198 82 100 104 172 174 173 175 232 219 214 213 212 211 210 209 208 130 Serine/threonine-protein kinase MARK2
CAMK MARK3 MARK3_HUMAN AF-P27448-K1A P27448 48 315 753.0 No_ligand No_ligand Active DFGin 6.694 14.512 BLAminus DFGAsp-rot-in -123.88, 177.15 57.0, 72.45 200.85, 30.97 -81.46, 16.88 287.16, 80.97 -62.01, -29.4 in-in in 9.364 Saltbr-in 2.679 HRD-in -80.04, -47.96 63.78, 10.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 161.82 APE9-dihe-na 91.81, 172.25 APE8-dihe-in -69.14, 129.83 APE8-rot-in 285.11 APE67-dihe-in -65.12, -21.71 -52.38, -39.59 APE12-dist-in 8.617 APE11-dist-in 10.927 APE10-dist-in 5.122 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K1 CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MARK3 MARK3_HUMAN AF-P27448-K3A P27448 48 315 753.0 No_ligand No_ligand Active DFGin 6.352 14.451 BLAminus DFGAsp-rot-in -124.45, 174.68 54.69, 73.48 201.69, 17.66 -76.92, 15.34 286.64, 84.94 -60.36, -27.19 in-in in 9.376 Saltbr-in 2.708 HRD-in -82.76, -46.83 65.47, 2.4 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.79, 176.51 APE9-dihe-na 104.72, 167.44 APE8-dihe-in -77.75, 123.61 APE8-rot-in 298.54 APE67-dihe-in -65.05, -21.7 -51.25, -39.58 APE12-dist-in 8.275 APE11-dist-in 11.243 APE10-dist-in 5.714 APE9-dist-in 3.266 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K3 CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MARK4 MARK4_HUMAN AF-Q96L34-K1A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.61 14.515 BLAminus DFGAsp-rot-in -122.78, 175.62 57.43, 75.4 197.63, 27.43 -83.51, 15.79 288.38, 81.6 -61.42, -29.89 in-in in 9.403 Saltbr-in 2.676 HRD-in -81.36, -46.98 64.62, 5.83 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 160.83 APE9-dihe-na 91.36, 178.14 APE8-dihe-in -82.25, 129.5 APE8-rot-in 305.11 APE67-dihe-in -65.1, -22.7 -52.5, -39.41 APE12-dist-in 8.659 APE11-dist-in 10.936 APE10-dist-in 5.104 APE9-dist-in 3.387 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[59, 310]] 1.0 AF-Q96L34-K1 CAMK_MARK4_HUMAN CAMK 1.2e-96 328.9 1 256 256 198 199 200 202 204 88 106 110 178 180 179 181 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
CAMK MARK4 MARK4_HUMAN AF-Q96L34-K3A Q96L34 51 318 752.0 No_ligand No_ligand Active DFGin 6.268 14.502 BLAminus DFGAsp-rot-in -124.44, 174.67 54.29, 75.08 201.01, 13.85 -77.96, 14.05 285.8, 83.65 -59.86, -26.8 in-in in 9.414 Saltbr-in 2.713 HRD-in -85.11, -44.75 64.68, -2.73 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.5, 179.0 APE9-dihe-na 103.89, 166.78 APE8-dihe-in -78.31, 124.02 APE8-rot-in 298.22 APE67-dihe-in -65.41, -21.73 -51.15, -39.73 APE12-dist-in 8.312 APE11-dist-in 11.203 APE10-dist-in 5.713 APE9-dist-in 3.205 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[59, 310]] 1.0 AF-Q96L34-K3 CAMK_MARK4_HUMAN CAMK 1.2e-96 328.9 1 256 256 198 199 200 202 204 88 106 110 178 180 179 181 238 225 220 219 218 217 216 215 214 136 MAP/microtubule affinity-regulating kinase 4
CAMK MELK MELK_HUMAN AF-Q14680-K1A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.663 14.852 BLAminus DFGAsp-rot-in -121.05, -178.94 55.54, 67.09 199.52, 14.38 -78.42, 16.52 286.9, 79.58 -60.33, -23.28 in-in in 9.305 Saltbr-in 2.725 HRD-in -75.84, -50.36 66.57, 14.62 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 166.92 APE9-dihe-na 98.89, 172.09 APE8-dihe-in -67.52, 132.67 APE8-rot-in 286.83 APE67-dihe-in -68.01, -21.76 -55.55, -41.05 APE12-dist-in 8.665 APE11-dist-in 11.294 APE10-dist-in 5.675 APE9-dist-in 3.779 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[11, 263]] 1.0 AF-Q14680-K1 CAMK_MELK_HUMAN CAMK 4.6e-89 304.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN AF-Q14680-K3A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.498 14.825 BLAminus DFGAsp-rot-in -123.1, -178.85 53.35, 68.52 199.17, 6.4 -77.81, 16.02 289.31, 78.98 -63.89, -14.25 in-in in 9.214 Saltbr-in 2.705 HRD-in -77.78, -49.26 68.33, 6.33 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 171.36 APE9-dihe-na 95.07, 170.83 APE8-dihe-in -65.23, 128.46 APE8-rot-in 280.71 APE67-dihe-in -62.2, -18.93 -58.85, -41.82 APE12-dist-in 8.645 APE11-dist-in 11.607 APE10-dist-in 6.011 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[11, 263]] 1.0 AF-Q14680-K3 CAMK_MELK_HUMAN CAMK 4.6e-89 304.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MKNK1 MKNK1_HUMAN AF-Q9BUB5-K1A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.551 14.448 BLAminus DFGAsp-rot-in -139.51, 177.87 63.89, 76.2 206.43, 17.76 -93.98, 21.31 285.56, 81.43 -66.18, -24.6 in-in in 8.992 Saltbr-in 2.81 HRD-in -72.31, -45.84 65.95, -0.63 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.16, 168.03 APE9-dihe-na 111.05, 173.22 APE8-dihe-in -72.54, 133.69 APE8-rot-in 282.56 APE67-dihe-in -71.55, -19.98 -54.49, -39.36 APE12-dist-in 9.189 APE11-dist-in 11.349 APE10-dist-in 5.776 APE9-dist-in 3.501 None None None AF2 -1.0 1.0 1.0 A 343 343 0 0 0 0 [[48, 374]] 1.0 AF-Q9BUB5-K1 CAMK_MKNK1_HUMAN CAMK 3.1e-74 256.7 1 256 256 231 232 233 235 237 78 94 98 208 210 209 211 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
CAMK MKNK1 MKNK1_HUMAN AF-Q9BUB5-K3A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.401 14.203 BLAminus DFGAsp-rot-in -141.0, 178.88 62.92, 73.65 207.09, 15.68 -91.35, 18.98 284.34, 81.84 -65.7, -27.47 in-in in 8.85 Saltbr-in 2.793 HRD-in -75.5, -43.96 67.15, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.11, 176.01 APE9-dihe-na 93.67, 177.34 APE8-dihe-in -72.69, 132.8 APE8-rot-in 289.12 APE67-dihe-in -66.83, -21.71 -56.7, -37.4 APE12-dist-in 9.24 APE11-dist-in 11.362 APE10-dist-in 5.916 APE9-dist-in 3.579 None None None AF2 -1.0 1.0 1.0 A 343 343 0 0 0 0 [[48, 374]] 1.0 AF-Q9BUB5-K3 CAMK_MKNK1_HUMAN CAMK 3.1e-74 256.7 1 256 256 231 232 233 235 237 78 94 98 208 210 209 211 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
CAMK MKNK2 MKNK2_HUMAN AF-Q9HBH9-K1A Q9HBH9 75 376 465.0 No_ligand No_ligand Active DFGin 6.393 14.364 BLAminus DFGAsp-rot-in -141.02, 178.86 65.04, 73.59 207.29, 21.83 -89.93, 20.18 286.81, 82.92 -64.09, -30.08 in-in in 9.136 Saltbr-in 2.804 HRD-in -77.22, -47.35 66.72, -4.74 in-in-in SNCiii in-in ActLoopNT-in 3.095 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.82, 171.77 APE9-dihe-na 99.55, -179.55 APE8-dihe-in -82.75, 130.0 APE8-rot-in 306.39 APE67-dihe-in -68.27, -19.61 -55.07, -38.24 APE12-dist-in 9.182 APE11-dist-in 11.371 APE10-dist-in 5.872 APE9-dist-in 3.686 None None None AF2 -1.0 1.0 1.0 A 302 302 0 0 0 0 [[83, 368]] 1.0 AF-Q9HBH9-K1 CAMK_MKNK2_HUMAN CAMK 3.2e-78 268.6 1 256 256 225 226 227 229 231 113 129 133 202 204 203 205 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK MKNK2 MKNK2_HUMAN AF-Q9HBH9-K3A Q9HBH9 75 376 465.0 No_ligand No_ligand Active DFGin 6.371 14.521 BLAminus DFGAsp-rot-in -141.97, -178.36 57.69, 78.48 209.24, 12.25 -93.77, 17.96 290.64, 88.53 -63.76, -30.47 in-in in 8.865 Saltbr-in 2.697 HRD-in -75.8, -44.73 66.37, -11.7 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.19, 164.07 APE9-dihe-na 129.41, -179.44 APE8-dihe-in -84.02, 126.95 APE8-rot-in 303.13 APE67-dihe-in -69.33, -27.45 -56.26, -30.53 APE12-dist-in 9.217 APE11-dist-in 11.307 APE10-dist-in 5.828 APE9-dist-in 3.252 None None None AF2 -1.0 1.0 1.0 A 302 302 0 0 0 0 [[83, 368]] 1.0 AF-Q9HBH9-K3 CAMK_MKNK2_HUMAN CAMK 3.2e-78 268.6 1 256 256 225 226 227 229 231 113 129 133 202 204 203 205 277 260 255 254 253 252 251 250 249 160 MAP kinase-interacting serine/threonine-protein kinase 2
CAMK MYLK MYLK_HUMAN AF-Q15746-K1A Q15746 1456 1727 1914.0 No_ligand No_ligand Active DFGin 6.371 14.063 BLAminus DFGAsp-rot-in -129.36, 175.69 56.22, 81.24 204.96, 7.66 -90.29, 16.8 297.61, 92.62 -60.18, -28.87 in-in in 9.134 Saltbr-in 2.828 HRD-in -82.52, -44.33 63.49, 10.36 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.37, 155.18 APE9-dihe-na 105.56, 176.74 APE8-dihe-in -82.12, 122.1 APE8-rot-in 301.66 APE67-dihe-in -63.89, -31.32 -47.73, -43.36 APE12-dist-in 10.512 APE11-dist-in 12.049 APE10-dist-in 6.476 APE9-dist-in 5.284 None None None AF2 -1.0 1.0 1.0 A 272 272 0 0 0 0 [[1464, 1719]] 1.0 AF-Q15746-K1 CAMK_MYLK_HUMAN CAMK 8.9e-89 303.1 1 256 256 1604 1605 1606 1608 1610 1493 1509 1513 1582 1584 1583 1585 1643 1631 1626 1625 1624 1623 1622 1621 1620 1539 Myosin light chain kinase, smooth muscle
CAMK MYLK MYLK_HUMAN AF-Q15746-K3A Q15746 1456 1727 1914.0 No_ligand No_ligand Active DFGin 6.155 14.082 BLAminus DFGAsp-rot-in -129.67, 176.87 55.25, 79.7 205.48, 3.02 -87.33, 14.87 297.18, 94.44 -60.26, -28.26 in-in in 9.266 Saltbr-in 2.9 HRD-in -87.41, -46.29 66.02, 10.91 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.17, 162.42 APE9-dihe-na 139.3, 174.4 APE8-dihe-in -87.0, 127.89 APE8-rot-in 309.0 APE67-dihe-in -75.44, -30.27 -50.44, -33.86 APE12-dist-in 7.859 APE11-dist-in 11.578 APE10-dist-in 6.827 APE9-dist-in 4.593 None None None AF2 -1.0 1.0 1.0 A 272 272 0 0 0 0 [[1464, 1719]] 1.0 AF-Q15746-K3 CAMK_MYLK_HUMAN CAMK 8.9e-89 303.1 1 256 256 1604 1605 1606 1608 1610 1493 1509 1513 1582 1584 1583 1585 1643 1631 1626 1625 1624 1623 1622 1621 1620 1539 Myosin light chain kinase, smooth muscle
CAMK MYLK2 MYLK2_HUMAN AF-Q9H1R3-K1A Q9H1R3 275 548 596.0 No_ligand No_ligand Active DFGin 6.17 13.524 BLAminus DFGAsp-rot-in -125.61, 177.06 58.14, 72.22 202.98, 15.19 -80.86, 16.84 300.19, 104.44 -60.25, -29.25 in-in in 9.101 Saltbr-in 2.736 HRD-in -77.26, -49.24 63.47, 0.97 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.24, 157.42 APE9-dihe-na 132.27, 177.77 APE8-dihe-in -83.65, 124.86 APE8-rot-in 299.0 APE67-dihe-in -57.47, -30.01 -46.9, -45.42 APE12-dist-in 8.253 APE11-dist-in 11.859 APE10-dist-in 6.812 APE9-dist-in 4.54 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[285, 540]] 1.0 AF-Q9H1R3-K1 CAMK_MYLK2_HUMAN CAMK 1.9e-84 289.1 4 256 253 425 426 427 429 431 314 330 334 403 405 404 406 464 452 447 446 445 444 443 442 441 360 Myosin light chain kinase 2, skeletal/cardiac muscle
CAMK MYLK2 MYLK2_HUMAN AF-Q9H1R3-K3A Q9H1R3 275 548 596.0 No_ligand No_ligand Active DFGin 5.854 13.385 BLAminus DFGAsp-rot-in -127.09, 178.7 58.07, 69.72 201.62, 8.18 -79.89, 14.62 303.71, 102.01 -62.29, -28.3 in-in in 8.826 Saltbr-in 2.703 HRD-in -81.15, -47.46 63.41, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.14, 159.93 APE9-dihe-na 137.17, -175.13 APE8-dihe-in -88.93, 123.39 APE8-rot-in 303.83 APE67-dihe-in -60.01, -31.82 -46.13, -48.61 APE12-dist-in 8.2 APE11-dist-in 11.563 APE10-dist-in 6.724 APE9-dist-in 3.99 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[285, 540]] 1.0 AF-Q9H1R3-K3 CAMK_MYLK2_HUMAN CAMK 1.9e-84 289.1 4 256 253 425 426 427 429 431 314 330 334 403 405 404 406 464 452 447 446 445 444 443 442 441 360 Myosin light chain kinase 2, skeletal/cardiac muscle
CAMK MYLK3 MYLK3_HUMAN AF-Q32MK0-K1A Q32MK0 505 778 819.0 No_ligand No_ligand Active DFGin 6.561 13.874 BLAminus DFGAsp-rot-in -127.56, 179.78 59.63, 64.67 204.71, 16.31 -77.3, 14.76 293.67, 90.78 -61.27, -30.98 in-in in 9.188 Saltbr-in 2.731 HRD-in -76.56, -47.25 63.71, 2.93 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.41, 163.98 APE9-dihe-na 125.56, 171.88 APE8-dihe-in -76.85, 127.12 APE8-rot-in 295.87 APE67-dihe-in -58.5, -27.62 -46.3, -47.09 APE12-dist-in 8.298 APE11-dist-in 11.803 APE10-dist-in 6.797 APE9-dist-in 4.391 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[513, 770]] 1.0 AF-Q32MK0-K1 CAMK_MYLK3_HUMAN CAMK 2.2e-87 298.6 4 256 253 655 656 657 659 661 544 560 564 633 635 634 636 694 682 677 676 675 674 673 672 671 590 Myosin light chain kinase 3
CAMK MYLK3 MYLK3_HUMAN AF-Q32MK0-K3A Q32MK0 505 778 819.0 No_ligand No_ligand Active DFGin 6.131 13.788 BLAminus DFGAsp-rot-in -127.45, 179.71 54.69, 76.32 202.85, 0.25 -82.96, 14.09 296.64, 99.89 -59.14, -31.18 in-in in 9.169 Saltbr-in 2.69 HRD-in -81.99, -46.14 66.86, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.39, 162.19 APE9-dihe-na 137.85, 178.7 APE8-dihe-in -87.11, 125.83 APE8-rot-in 311.97 APE67-dihe-in -60.06, -28.48 -46.89, -46.31 APE12-dist-in 8.045 APE11-dist-in 11.521 APE10-dist-in 7.483 APE9-dist-in 5.115 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[513, 770]] 1.0 AF-Q32MK0-K3 CAMK_MYLK3_HUMAN CAMK 2.2e-87 298.6 4 256 253 655 656 657 659 661 544 560 564 633 635 634 636 694 682 677 676 675 674 673 672 671 590 Myosin light chain kinase 3
CAMK MYLK4 MYLK4_HUMAN AF-Q86YV6-K1A Q86YV6 96 369 388.0 No_ligand No_ligand Active DFGin 6.168 13.671 BLAminus DFGAsp-rot-in -123.76, 177.22 58.12, 74.61 201.7, 15.6 -83.18, 16.73 298.72, 103.28 -59.31, -32.51 in-in in 9.161 Saltbr-in 2.778 HRD-in -78.56, -49.82 62.36, 13.93 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.01, 162.01 APE9-dihe-na 125.05, 175.6 APE8-dihe-in -85.72, 124.99 APE8-rot-in 309.59 APE67-dihe-in -56.95, -29.01 -46.3, -45.91 APE12-dist-in 8.309 APE11-dist-in 11.831 APE10-dist-in 6.852 APE9-dist-in 4.772 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[104, 361]] 1.0 AF-Q86YV6-K1 CAMK_MYLK4_HUMAN CAMK 1.6e-86 295.7 5 256 252 246 247 248 250 252 135 151 155 224 226 225 227 285 273 268 267 266 265 264 263 262 181 Myosin light chain kinase family member 4
CAMK MYLK4 MYLK4_HUMAN AF-Q86YV6-K3A Q86YV6 96 369 388.0 No_ligand No_ligand Active DFGin 5.898 13.485 BLAminus DFGAsp-rot-in -127.05, -179.68 55.11, 75.49 204.97, -1.71 -84.43, 16.06 303.59, 104.43 -58.98, -33.28 in-in in 9.147 Saltbr-in 2.748 HRD-in -81.51, -47.62 67.83, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.47, 163.06 APE9-dihe-na 133.9, 176.55 APE8-dihe-in -81.28, 124.88 APE8-rot-in 305.78 APE67-dihe-in -60.11, -28.48 -47.26, -46.08 APE12-dist-in 7.747 APE11-dist-in 11.452 APE10-dist-in 7.355 APE9-dist-in 4.975 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[104, 361]] 1.0 AF-Q86YV6-K3 CAMK_MYLK4_HUMAN CAMK 1.6e-86 295.7 5 256 252 246 247 248 250 252 135 151 155 224 226 225 227 285 273 268 267 266 265 264 263 262 181 Myosin light chain kinase family member 4
CAMK NIM1K NIM1_HUMAN AF-Q8IY84-K1A Q8IY84 66 333 436.0 No_ligand No_ligand Active DFGin 5.995 14.002 BLAminus DFGAsp-rot-in -137.37, -172.44 57.27, 82.6 197.86, 13.07 -90.31, 17.88 292.16, 85.71 -59.39, -25.34 in-in in 9.085 Saltbr-in 2.702 HRD-in -75.81, -48.36 64.47, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.15, 172.7 APE9-dihe-na 113.83, 167.62 APE8-dihe-in -81.03, 124.01 APE8-rot-in 300.58 APE67-dihe-in -65.5, -22.45 -50.78, -38.19 APE12-dist-in 8.796 APE11-dist-in 11.065 APE10-dist-in 5.61 APE9-dist-in 3.356 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[74, 325]] 1.0 AF-Q8IY84-K1 CAMK_NIM1K_HUMAN CAMK 5.9e-84 287.3 1 256 256 213 214 215 217 219 103 121 125 193 195 194 196 253 240 235 234 233 232 231 230 229 151 Serine/threonine-protein kinase NIM1
CAMK NIM1K NIM1_HUMAN AF-Q8IY84-K3A Q8IY84 66 333 436.0 No_ligand No_ligand Active DFGin 5.694 14.1 BLAminus DFGAsp-rot-in -138.23, -167.21 51.69, 83.84 197.73, -1.75 -88.27, 16.35 291.01, 91.02 -59.74, -26.02 in-in in 8.958 Saltbr-in 2.657 HRD-in -77.45, -46.21 63.35, 8.18 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.07, 178.64 APE9-dihe-na 102.0, 165.91 APE8-dihe-in -69.62, 126.54 APE8-rot-in 278.02 APE67-dihe-in -65.25, -21.32 -52.76, -37.17 APE12-dist-in 8.584 APE11-dist-in 11.054 APE10-dist-in 5.599 APE9-dist-in 3.359 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[74, 325]] 1.0 AF-Q8IY84-K3 CAMK_NIM1K_HUMAN CAMK 5.9e-84 287.3 1 256 256 213 214 215 217 219 103 121 125 193 195 194 196 253 240 235 234 233 232 231 230 229 151 Serine/threonine-protein kinase NIM1
CAMK NUAK1 NUAK1_HUMAN AF-O60285-K1A O60285 47 314 661.0 No_ligand No_ligand Active DFGin 6.277 15.002 BLAminus DFGAsp-rot-in -126.08, -179.63 52.64, 70.69 201.14, 15.93 -81.14, 17.19 284.02, 75.44 -61.11, -24.41 in-in in 9.46 Saltbr-in 2.61 HRD-in -80.99, -46.07 64.23, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.2, 174.37 APE9-dihe-na 104.22, 165.25 APE8-dihe-in -63.13, 129.05 APE8-rot-in 282.09 APE67-dihe-in -70.73, -17.88 -53.83, -34.13 APE12-dist-in 8.139 APE11-dist-in 11.409 APE10-dist-in 5.739 APE9-dist-in 3.65 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[55, 306]] 1.0 AF-O60285-K1 CAMK_NUAK1_HUMAN CAMK 1.4e-93 318.8 1 256 256 195 196 197 199 201 84 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 NUAK family SNF1-like kinase 1
CAMK NUAK1 NUAK1_HUMAN AF-O60285-K3A O60285 47 314 661.0 No_ligand No_ligand Active DFGin 5.997 15.229 BLAminus DFGAsp-rot-in -131.38, 178.33 52.25, 71.16 205.28, -14.35 -78.03, 17.18 283.71, 76.93 -59.84, -27.55 in-in in 9.458 Saltbr-in 2.628 HRD-in -83.2, -44.64 63.9, 9.44 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.66, 175.05 APE9-dihe-na 107.19, 165.97 APE8-dihe-in -72.59, 126.54 APE8-rot-in 300.46 APE67-dihe-in -71.53, -18.19 -54.52, -33.93 APE12-dist-in 8.252 APE11-dist-in 11.475 APE10-dist-in 6.0 APE9-dist-in 3.376 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[55, 306]] 1.0 AF-O60285-K3 CAMK_NUAK1_HUMAN CAMK 1.4e-93 318.8 1 256 256 195 196 197 199 201 84 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 NUAK family SNF1-like kinase 1
CAMK NUAK2 NUAK2_HUMAN AF-Q9H093-K1A Q9H093 45 311 628.0 No_ligand No_ligand Active DFGin 6.321 15.042 BLAminus DFGAsp-rot-in -122.58, -173.69 48.16, 67.96 202.06, 19.48 -80.76, 18.56 283.8, 74.79 -60.44, -27.7 in-in in 9.456 Saltbr-in 2.631 HRD-in -82.03, -44.92 63.5, 9.74 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.52, 177.52 APE9-dihe-na 101.12, 165.57 APE8-dihe-in -73.33, 129.83 APE8-rot-in 304.4 APE67-dihe-in -72.84, -17.36 -53.68, -35.58 APE12-dist-in 8.273 APE11-dist-in 11.397 APE10-dist-in 5.701 APE9-dist-in 3.549 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[53, 303]] 1.0 AF-Q9H093-K1 CAMK_NUAK2_HUMAN CAMK 1.5e-90 309.0 1 256 256 192 193 194 196 198 81 100 104 172 174 173 175 232 219 214 213 212 211 210 209 208 130 NUAK family SNF1-like kinase 2
CAMK NUAK2 NUAK2_HUMAN AF-Q9H093-K3A Q9H093 45 311 628.0 No_ligand No_ligand Active DFGin 5.978 15.184 BLAminus DFGAsp-rot-in -133.03, 177.49 53.22, 70.32 205.2, -14.04 -77.68, 17.05 283.7, 76.93 -58.74, -30.59 in-in in 9.336 Saltbr-in 2.64 HRD-in -82.7, -44.99 64.49, 10.45 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 177.72 APE9-dihe-na 99.03, 170.58 APE8-dihe-in -78.16, 124.75 APE8-rot-in 302.81 APE67-dihe-in -68.89, -20.7 -54.47, -33.13 APE12-dist-in 8.126 APE11-dist-in 11.48 APE10-dist-in 5.953 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[53, 303]] 1.0 AF-Q9H093-K3 CAMK_NUAK2_HUMAN CAMK 1.5e-90 309.0 1 256 256 192 193 194 196 198 81 100 104 172 174 173 175 232 219 214 213 212 211 210 209 208 130 NUAK family SNF1-like kinase 2
CAMK OBSCN-1 OBSCN_HUMAN AF-Q5VST9-K1A Q5VST9 6460 6729 7968.0 No_ligand No_ligand Active DFGin 6.669 13.564 BLAminus DFGAsp-rot-in -131.59, 169.59 58.39, 84.58 198.28, 5.46 -88.71, 21.98 287.8, 79.98 -61.16, -29.82 in-in in 8.362 Saltbr-in 2.606 HRD-in -82.56, -43.55 61.97, 11.85 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.04, 148.77 APE9-dihe-na 170.22, 160.14 APE8-dihe-in -82.18, 134.71 APE8-rot-in 303.1 APE67-dihe-in -88.7, -21.57 -52.8, -32.11 APE12-dist-in 7.59 APE11-dist-in 10.378 APE10-dist-in 6.508 APE9-dist-in 4.723 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[6468, 6721], [7672, 7924]] 2.0 AF-Q5VST9-K1 CAMK_OBSCN-1_HUMAN CAMK 2.8e-78 268.7 1 256 256 6606 6607 6608 6610 6612 6497 6512 6516 6584 6586 6585 6587 6645 6633 6628 6627 6626 6625 6624 6623 6622 6542 Obscurin
CAMK OBSCN-1 OBSCN_HUMAN AF-Q5VST9-K3A Q5VST9 6460 6729 7968.0 No_ligand No_ligand Active DFGin 6.441 13.605 BLAminus DFGAsp-rot-in -130.36, 168.0 55.74, 81.66 199.7, -8.33 -83.42, 22.32 288.94, 79.09 -60.05, -30.95 in-in in 8.277 Saltbr-in 2.601 HRD-in -83.45, -46.51 62.55, 9.2 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 160.51 APE9-dihe-na 154.82, 167.76 APE8-dihe-in -80.25, 134.36 APE8-rot-in 290.26 APE67-dihe-in -75.39, -28.28 -52.36, -33.97 APE12-dist-in 7.12 APE11-dist-in 9.71 APE10-dist-in 6.74 APE9-dist-in 4.77 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[6468, 6721], [7672, 7924]] 2.0 AF-Q5VST9-K3 CAMK_OBSCN-1_HUMAN CAMK 2.8e-78 268.7 1 256 256 6606 6607 6608 6610 6612 6497 6512 6516 6584 6586 6585 6587 6645 6633 6628 6627 6626 6625 6624 6623 6622 6542 Obscurin
CAMK OBSCN-2 OBSCN_HUMAN AF-Q5VST9-K4A Q5VST9 7664 7932 7968.0 No_ligand No_ligand Active DFGin 5.906 12.364 BLAminus DFGAsp-rot-in -123.28, 176.06 55.87, 66.72 199.32, 4.71 -72.66, 21.84 281.79, 79.94 -61.55, -30.35 in-in in 8.213 Saltbr-in 2.625 HRD-in -80.88, -45.31 63.13, 20.06 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -110.75, 19.97 APE9-dihe-na -67.69, 174.24 APE8-dihe-in -79.02, 142.29 APE8-rot-na 286.21 APE67-dihe-in -59.02, -31.84 -70.7, -38.06 APE12-dist-in 10.132 APE11-dist-in 8.561 APE10-dist-in 7.904 APE9-dist-in 4.983 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[6468, 6721], [7672, 7924]] 2.0 AF-Q5VST9-K4 CAMK_OBSCN-2_HUMAN CAMK 9.8e-64 221.1 2 256 255 7808 7809 7810 7812 7814 7701 7716 7720 7788 7790 7789 7791 7849 7837 7832 7831 7830 7829 7828 7827 7826 7746 Obscurin
CAMK PASK PASK_HUMAN 3DLSA Q96RG2 982 1266 1323.0 ADP:1 ATPlike Active DFGin 6.001 14.204 BLAminus DFGAsp-rot-in -129.0, 178.94 63.52, 79.16 189.56, 0.4 -100.96, 27.03 282.44, 72.76 -70.92, -15.42 in-in in 8.655 Saltbr-in 2.605 HRD-na-E -71.55, -40.2 72.7, 1.22 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.6, 5.88 APE9-dihe-na -96.65, -154.85 APE8-dihe-in -98.92, 122.93 APE8-rot-in 302.12 APE67-dihe-in -72.66, -14.95 -65.45, -19.89 APE12-dist-in 10.203 APE11-dist-in 10.574 APE10-dist-in 5.061 APE9-dist-in 3.451 None None None XRAY 2.3 0.244 0.297 A 335 285 0 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB Q96RG2 982 1267 1323.0 ADP:2 ATPlike Active DFGin 6.1 14.087 BLAminus DFGAsp-rot-in -126.55, 179.43 61.31, 80.64 193.24, 3.87 -98.16, 22.24 284.4, 71.69 -72.83, -6.95 in-in in 8.346 Saltbr-in 2.677 HRD-na-E -67.25, -43.38 72.94, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.86, 22.09 APE9-dihe-na -121.63, -155.86 APE8-dihe-in -97.56, 124.97 APE8-rot-in 306.83 APE67-dihe-in -68.7, -17.81 -61.84, -27.67 APE12-dist-in 10.243 APE11-dist-in 10.688 APE10-dist-in 5.149 APE9-dist-in 3.521 None None None XRAY 2.3 0.244 0.297 B 335 280 6 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC Q96RG2 982 1267 1323.0 ADP:3 ATPlike Active DFGin 6.549 14.136 BLAminus DFGAsp-rot-in -121.24, -178.98 61.8, 81.93 188.47, 3.45 -100.03, 24.34 279.06, 77.86 -70.4, -24.84 in-in in 8.286 Saltbr-in 2.707 HRD-na-E -75.53, -39.96 73.3, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.16, 23.96 APE9-dihe-na -111.98, -161.37 APE8-dihe-in -95.46, 124.23 APE8-rot-in 302.16 APE67-dihe-in -72.29, -18.02 -57.94, -30.36 APE12-dist-in 9.98 APE11-dist-in 10.437 APE10-dist-in 4.962 APE9-dist-in 3.466 None None None XRAY 2.3 0.244 0.297 C 335 281 5 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD Q96RG2 982 1266 1323.0 ADP:4 ATPlike Active DFGin 5.989 14.037 BLAminus DFGAsp-rot-in -119.78, -174.43 57.15, 82.44 200.97, -3.31 -96.61, 20.08 283.36, 68.59 -63.18, -13.75 in-in in 8.596 Saltbr-in 2.674 HRD-na-E -66.59, -43.13 75.45, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.17, 8.76 APE9-dihe-na -100.36, -154.44 APE8-dihe-in -94.34, 129.8 APE8-rot-in 309.84 APE67-dihe-in -63.24, -17.05 -59.73, -34.41 APE12-dist-in 10.579 APE11-dist-in 10.601 APE10-dist-in 5.212 APE9-dist-in 3.318 None None None XRAY 2.3 0.244 0.297 D 335 284 1 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE Q96RG2 982 1267 1323.0 ADP:5 ATPlike Active DFGin 6.351 14.113 BLAminus DFGAsp-rot-in -115.03, 172.38 61.43, 82.92 191.02, 11.87 -98.38, 26.76 287.19, 66.36 -61.94, -22.57 in-in in 8.272 Saltbr-in 3.015 HRD-na-E -64.64, -41.08 75.56, -14.47 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.8, 6.63 APE9-dihe-na -93.38, -160.98 APE8-dihe-in -92.63, 131.98 APE8-rot-in 304.09 APE67-dihe-in -71.09, -14.17 -58.49, -32.88 APE12-dist-in 10.767 APE11-dist-in 10.575 APE10-dist-in 5.072 APE9-dist-in 3.423 None None None XRAY 2.3 0.244 0.297 E 335 282 4 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF Q96RG2 982 1266 1323.0 ADP:6 ATPlike Active DFGin 6.208 14.428 BLAminus DFGAsp-rot-in -120.86, -179.45 54.8, 74.61 199.47, 17.63 -87.61, 27.75 280.29, 66.66 -72.72, -14.22 in-in in 8.492 Saltbr-in 2.879 HRD-na-E -64.59, -48.9 86.1, -8.79 in-in-in SNCiii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.3, 4.74 APE9-dihe-na -89.15, -152.34 APE8-dihe-in -104.88, 132.7 APE8-rot-in 302.97 APE67-dihe-in -72.03, -17.52 -62.59, -27.45 APE12-dist-in 10.486 APE11-dist-in 10.547 APE10-dist-in 5.101 APE9-dist-in 3.284 None None None XRAY 2.3 0.244 0.297 F 335 281 4 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.8e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN AF-Q96RG2-K1A Q96RG2 991 1259 1323.0 No_ligand No_ligand Active DFGin 6.344 14.129 BLAminus DFGAsp-rot-in -122.95, 177.51 55.91, 78.39 205.24, -14.32 -88.24, 20.94 283.8, 65.19 -58.45, -30.7 in-in in 8.474 Saltbr-in 2.722 HRD-na-E -76.26, -42.21 63.12, -0.12 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.63, 14.58 APE9-dihe-na -107.38, -170.0 APE8-dihe-in -73.49, 132.1 APE8-rot-in 289.95 APE67-dihe-in -62.96, -20.07 -61.7, -39.9 APE12-dist-in 10.453 APE11-dist-in 10.04 APE10-dist-in 4.793 APE9-dist-in 3.72 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[999, 1251]] 1.0 AF-Q96RG2-K1 CAMK_PASK_HUMAN CAMK 1.3e-67 233.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN AF-Q96RG2-K3A Q96RG2 991 1259 1323.0 No_ligand No_ligand Active DFGin 6.206 13.852 BLAminus DFGAsp-rot-in -125.72, 177.65 54.89, 78.12 206.95, -23.22 -85.32, 19.58 283.04, 67.18 -59.22, -29.92 in-in in 8.419 Saltbr-in 2.697 HRD-na-E -78.49, -38.35 64.77, -14.05 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.09, 128.47 APE9-dihe-na 131.78, -153.84 APE8-dihe-in -108.18, 131.52 APE8-rot-in 303.82 APE67-dihe-in -65.49, -12.81 -61.9, -39.46 APE12-dist-in 10.322 APE11-dist-in 10.318 APE10-dist-in 4.629 APE9-dist-in 4.091 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[999, 1251]] 1.0 AF-Q96RG2-K3 CAMK_PASK_HUMAN CAMK 1.3e-67 233.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PHKG1 PHKG1_HUMAN AF-Q16816-K1A Q16816 12 296 387.0 No_ligand No_ligand Active DFGin 6.199 14.416 BLAminus DFGAsp-rot-in -131.9, -179.44 59.62, 67.69 201.7, 28.28 -80.24, 19.99 289.56, 79.21 -62.9, -26.71 in-in in 9.063 Saltbr-in 2.745 HRD-in -75.62, -43.53 66.0, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 154.84 APE9-dihe-na 113.44, 173.75 APE8-dihe-in -77.57, 126.38 APE8-rot-in 297.31 APE67-dihe-in -73.26, -15.41 -50.26, -36.56 APE12-dist-in 8.958 APE11-dist-in 11.814 APE10-dist-in 6.072 APE9-dist-in 4.236 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[20, 288]] 1.0 AF-Q16816-K1 CAMK_PHKG1_HUMAN CAMK 5e-86 294.2 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN AF-Q16816-K3A Q16816 12 296 387.0 No_ligand No_ligand Active DFGin 5.969 14.37 BLAminus DFGAsp-rot-in -137.09, 179.17 57.22, 71.27 206.1, 4.34 -81.78, 17.32 290.82, 79.41 -61.1, -28.49 in-in in 9.028 Saltbr-in 2.771 HRD-in -81.29, -44.43 69.69, -10.21 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 169.84 APE9-dihe-na 89.47, -173.83 APE8-dihe-in -90.55, 126.69 APE8-rot-in 302.48 APE67-dihe-in -77.8, -15.35 -51.22, -33.51 APE12-dist-in 8.812 APE11-dist-in 11.252 APE10-dist-in 5.536 APE9-dist-in 3.657 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[20, 288]] 1.0 AF-Q16816-K3 CAMK_PHKG1_HUMAN CAMK 5e-86 294.2 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG2 PHKG2_HUMAN AF-P15735-K1A P15735 16 299 406.0 No_ligand No_ligand Active DFGin 6.308 14.247 BLAminus DFGAsp-rot-in -138.17, 176.17 58.28, 71.68 201.06, 27.99 -82.76, 17.41 285.76, 76.72 -61.18, -28.65 in-in in 9.071 Saltbr-in 2.741 HRD-in -78.84, -43.82 66.62, 4.04 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.75, 159.57 APE9-dihe-na 103.32, 175.61 APE8-dihe-in -85.04, 127.84 APE8-rot-in 304.17 APE67-dihe-in -71.84, -13.48 -49.78, -37.81 APE12-dist-in 8.967 APE11-dist-in 11.718 APE10-dist-in 5.896 APE9-dist-in 3.792 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[24, 291]] 1.0 AF-P15735-K1 CAMK_PHKG2_HUMAN CAMK 1.6e-87 299.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PHKG2 PHKG2_HUMAN AF-P15735-K3A P15735 16 299 406.0 No_ligand No_ligand Active DFGin 5.967 14.564 BLAminus DFGAsp-rot-in -140.45, -179.53 53.95, 78.82 205.63, 6.11 -88.53, 18.21 284.73, 74.11 -60.79, -30.19 in-in in 9.235 Saltbr-in 3.104 HRD-in -86.18, -42.63 67.48, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.97, 164.75 APE9-dihe-na 92.52, -175.11 APE8-dihe-in -92.93, 127.07 APE8-rot-in 300.95 APE67-dihe-in -75.12, -13.92 -50.02, -36.61 APE12-dist-in 8.699 APE11-dist-in 11.533 APE10-dist-in 5.677 APE9-dist-in 3.421 None None None AF2 -1.0 1.0 1.0 A 284 284 0 0 0 0 [[24, 291]] 1.0 AF-P15735-K3 CAMK_PHKG2_HUMAN CAMK 1.6e-87 299.0 1 256 256 170 171 172 174 176 53 77 81 150 152 151 153 215 197 192 191 190 189 188 187 186 108 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
CAMK PIM1 PIM1_HUMAN 1YXTA P11309 33 306 313.0 ANP:322 ATPlike Active DFGin 6.029 14.245 BLAminus DFGAsp-rot-in -131.81, 176.98 66.39, 83.69 190.4, -4.07 -99.64, 19.64 287.53, 80.25 -65.72, -15.35 in-in in 8.309 Saltbr-in 2.894 HRD-na-A -67.95, -50.18 66.45, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.69, 12.99 APE9-dihe-na -80.03, -158.46 APE8-dihe-in -83.46, 121.7 APE8-rot-in 308.53 APE67-dihe-in -70.36, -3.81 -49.69, -52.76 APE12-dist-in 9.729 APE11-dist-in 8.665 APE10-dist-in 5.279 APE9-dist-in 3.805 None None None XRAY 2.0 0.183 0.216 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxt CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUA P11309 33 305 313.0 AMP:550 ATPlike Active DFGin 6.045 14.58 BLAminus DFGAsp-rot-in -128.48, 170.01 62.85, 77.77 200.95, 13.25 -90.35, 20.24 287.6, 77.99 -74.7, 1.63 in-in in 8.513 Saltbr-in 2.486 HRD-na-A -60.24, -50.74 67.33, 4.52 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.18, 25.46 APE9-dihe-na -90.91, -158.18 APE8-dihe-in -86.5, 120.86 APE8-rot-in 310.09 APE67-dihe-in -63.06, -9.2 -60.21, -45.83 APE12-dist-in 9.959 APE11-dist-in 8.835 APE10-dist-in 5.689 APE9-dist-in 3.869 None None None XRAY 2.24 0.231 0.276 A 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUB P11309 33 305 313.0 AMP:650 ATPlike Active DFGin 6.12 14.673 BLAminus DFGAsp-rot-in -120.37, 167.93 65.74, 85.44 201.4, 10.15 -95.36, 14.03 285.37, 78.45 -64.71, -9.22 in-in in 8.6 Saltbr-in 2.814 HRD-na-A -59.51, -51.25 68.06, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.12, 36.18 APE9-dihe-na -84.74, -152.35 APE8-dihe-in -93.27, 122.65 APE8-rot-in 302.12 APE67-dihe-in -68.21, -7.03 -55.31, -45.11 APE12-dist-in 9.8 APE11-dist-in 8.534 APE10-dist-in 5.457 APE9-dist-in 3.841 None None None XRAY 2.24 0.231 0.276 B 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUC P11309 34 305 313.0 AMP:750 ATPlike Active DFGin 6.11 14.741 BLAminus DFGAsp-rot-in -134.94, 167.86 62.59, 83.1 190.94, 30.23 -95.62, 21.45 280.06, 80.63 -81.83, 7.92 in-in in 8.716 Saltbr-in 2.612 HRD-na-A -67.31, -48.53 67.93, 5.85 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.01, 44.98 APE9-dihe-na -103.92, -155.25 APE8-dihe-in -86.11, 117.99 APE8-rot-in 310.09 APE67-dihe-in -68.22, -9.23 -52.45, -45.39 APE12-dist-in 9.697 APE11-dist-in 8.654 APE10-dist-in 5.604 APE9-dist-in 3.847 None None None XRAY 2.24 0.231 0.276 C 293 272 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXUD P11309 33 305 313.0 AMP:850 ATPlike Active DFGin 6.236 14.556 BLAminus DFGAsp-rot-in -126.04, 169.08 67.7, 73.28 207.52, -11.59 -88.52, 13.94 289.01, 78.99 -70.28, -2.85 in-in in 8.789 Saltbr-in 2.466 HRD-na-A -64.06, -51.29 66.47, 10.4 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.8, 31.82 APE9-dihe-na -93.66, -159.09 APE8-dihe-in -85.99, 118.35 APE8-rot-in 303.12 APE67-dihe-in -71.66, -13.36 -52.91, -39.75 APE12-dist-in 9.896 APE11-dist-in 8.645 APE10-dist-in 5.457 APE9-dist-in 3.827 None None None XRAY 2.24 0.231 0.276 D 293 273 0 0 0 0 [[38, 290]] 1.0 1yxu CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A P11309 32 308 313.0 ANP:501 ATPlike Active DFGin 5.888 14.214 BLAminus DFGAsp-rot-in -138.05, 176.98 59.78, 85.31 195.43, 11.93 -96.55, 16.88 287.93, 82.19 -61.38, -7.19 in-in in 8.717 Saltbr-in 2.833 HRD-na-A -59.95, -51.82 71.23, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.05, 45.66 APE9-dihe-na -114.17, -171.15 APE8-dihe-in -64.11, 112.97 APE8-rot-in 299.41 APE67-dihe-in -49.28, -12.21 -42.84, -67.53 APE12-dist-in 9.608 APE11-dist-in 8.695 APE10-dist-in 5.522 APE9-dist-in 4.07 None None None XRAY 2.1 0.267 0.301 A 300 277 0 0 0 0 [[38, 290]] 1.0 1xr1 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A P11309 33 305 313.0 ANP:501 ATPlike Active DFGin 5.934 14.254 BLAminus DFGAsp-rot-in -128.38, 171.59 60.85, 87.29 194.13, 3.35 -96.61, 22.08 288.57, 75.78 -65.84, -9.23 in-in in 8.754 Saltbr-in 2.604 HRD-na-A -66.86, -47.45 66.12, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.19, 26.41 APE9-dihe-na -87.51, -159.07 APE8-dihe-in -85.64, 119.66 APE8-rot-in 305.41 APE67-dihe-in -70.7, -5.81 -56.65, -39.81 APE12-dist-in 9.612 APE11-dist-in 8.461 APE10-dist-in 5.29 APE9-dist-in 3.778 None None None XRAY 1.6 0.187 0.206 A 320 273 0 0 0 0 [[38, 290]] 1.0 3a99 CAMK_PIM1_HUMAN CAMK 4.4e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB P11309 33 305 313.0 ANP:1306 ATPlike Active DFGin 6.126 14.443 BLAminus DFGAsp-rot-in -123.86, 174.78 64.57, 79.13 197.93, -5.58 -87.5, 17.23 286.98, 86.61 -67.5, -17.62 in-in in 8.781 Saltbr-in 2.727 HRD-na-A -70.49, -48.81 68.36, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.63, 10.91 APE9-dihe-na -77.79, -156.22 APE8-dihe-in -90.85, 124.06 APE8-rot-in 315.85 APE67-dihe-in -68.94, -10.63 -60.69, -42.64 APE12-dist-in 9.464 APE11-dist-in 8.478 APE10-dist-in 4.851 APE9-dist-in 3.782 R250G None None XRAY 2.45 0.191 0.225 B 313 268 5 0 0 0 [[38, 290]] 1.0 2bzk CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXSA P11309 33 306 313.0 No_ligand No_ligand Active DFGin 6.043 14.691 BLAminus DFGAsp-rot-in -127.76, 171.69 59.08, 88.63 190.03, 17.37 -95.69, 24.45 285.74, 79.92 -71.89, -12.05 in-in in 8.836 Saltbr-in 2.515 HRD-na-A -69.25, -46.6 65.7, 9.18 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.7, 28.09 APE9-dihe-na -94.38, -153.78 APE8-dihe-in -89.3, 121.74 APE8-rot-in 312.97 APE67-dihe-in -69.81, -9.24 -57.4, -43.57 APE12-dist-in 9.611 APE11-dist-in 8.495 APE10-dist-in 5.323 APE9-dist-in 3.83 P123M None None XRAY 2.2 0.197 0.237 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxs CAMK_PIM1_HUMAN CAMK 5.9e-66 228.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN AF-P11309-K1A P11309 30 298 313.0 No_ligand No_ligand Active DFGin 5.924 14.426 BLAminus DFGAsp-rot-in -123.59, 173.12 59.42, 75.84 202.39, 9.32 -84.42, 19.94 286.93, 72.18 -59.74, -40.02 in-in in 8.502 Saltbr-in 2.692 HRD-na-A -69.93, -42.11 63.25, -11.96 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.01, 20.91 APE9-dihe-na -84.17, 176.91 APE8-dihe-in -67.72, 122.1 APE8-rot-in 305.72 APE67-dihe-in -69.25, -16.84 -56.89, -41.09 APE12-dist-in 9.579 APE11-dist-in 8.723 APE10-dist-in 4.83 APE9-dist-in 3.823 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[38, 290]] 1.0 AF-P11309-K1 CAMK_PIM1_HUMAN CAMK 2.4e-65 226.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN AF-P11309-K3A P11309 30 298 313.0 No_ligand No_ligand Active DFGin 5.794 14.284 BLAminus DFGAsp-rot-in -126.38, 175.52 54.92, 81.68 202.32, 0.74 -85.76, 15.39 286.52, 75.42 -58.44, -43.23 in-in in 8.48 Saltbr-in 2.675 HRD-na-A -72.55, -35.61 62.65, -28.81 in-in-in SNCiii in-in ActLoopNT-in 2.818 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.76, 133.51 APE9-dihe-na 135.29, -179.73 APE8-dihe-in -78.77, 123.98 APE8-rot-in 299.06 APE67-dihe-in -67.9, -19.52 -59.41, -42.11 APE12-dist-in 10.279 APE11-dist-in 9.215 APE10-dist-in 4.16 APE9-dist-in 4.434 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[38, 290]] 1.0 AF-P11309-K3 CAMK_PIM1_HUMAN CAMK 2.4e-65 226.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YWVA P11309 33 306 313.0 No_ligand No_ligand Active DFGin 6.107 14.685 BLAminus DFGAsp-rot-in -128.69, 170.23 59.45, 82.37 195.77, 0.45 -93.38, 16.91 284.75, 80.98 -65.5, -15.92 in-in in 8.875 Saltbr-in 2.404 HRD-na-A -68.35, -45.31 66.91, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.63, 18.4 APE9-dihe-na -83.53, -173.89 APE8-dihe-in -74.3, 128.16 APE8-rot-in 308.34 APE67-dihe-in -66.79, -7.76 -58.38, -49.12 APE12-dist-in 9.41 APE11-dist-in 8.688 APE10-dist-in 5.159 APE9-dist-in 3.945 None None None XRAY 2.0 0.213 0.239 A 293 274 0 0 0 0 [[38, 290]] 1.0 1ywv CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XQZA P11309 32 308 313.0 No_ligand No_ligand Active DFGin 6.113 14.323 BLAminus DFGAsp-rot-in -132.59, 173.59 55.58, 88.87 190.72, 7.57 -95.24, 18.48 288.46, 74.92 -59.23, -7.62 in-in in 8.454 Saltbr-in 2.834 HRD-na-A -64.93, -53.25 74.7, 0.79 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.51, 32.32 APE9-dihe-na -92.62, -159.59 APE8-dihe-in -84.16, 115.96 APE8-rot-in 305.78 APE67-dihe-in -51.85, -11.5 -41.07, -65.14 APE12-dist-in 9.632 APE11-dist-in 8.741 APE10-dist-in 5.585 APE9-dist-in 3.883 None None None XRAY 2.1 0.249 0.297 A 300 277 0 0 0 0 [[38, 290]] 1.0 1xqz CAMK_PIM1_HUMAN CAMK 3.5e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7VSYA P11309 33 305 313.0 No_ligand No_ligand Active DFGin 6.147 14.835 BLAminus DFGAsp-rot-in -134.49, 172.31 56.25, 85.19 196.65, 1.15 -90.8, 13.5 283.59, 75.74 -71.18, -5.96 in-in in 8.989 Saltbr-in 2.572 HRD-na-A -72.16, -48.61 72.01, 2.74 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.2, 35.54 APE9-dihe-na -94.69, -147.72 APE8-dihe-in -96.93, 120.22 APE8-rot-in 307.41 APE67-dihe-in -68.94, -11.56 -54.86, -45.03 APE12-dist-in 10.19 APE11-dist-in 8.741 APE10-dist-in 5.597 APE9-dist-in 3.897 N82K None None XRAY 2.141 0.198 0.22 A 326 273 0 0 0 0 [[38, 290]] 1.0 7vsy CAMK_PIM1_HUMAN CAMK 4.6e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4JX3A P11309 33 306 313.0 No_ligand No_ligand Active DFGin 6.255 14.862 BLAminus DFGAsp-rot-in -127.82, 159.43 82.11, 81.67 191.2, -6.34 -96.33, 22.05 278.91, 78.81 -66.22, -18.54 in-in in 9.035 Saltbr-in 2.864 HRD-na-A -65.27, -47.76 69.76, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.647 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.67, 50.36 APE9-dihe-na -106.43, -151.13 APE8-dihe-in -91.89, 110.71 APE8-rot-in 312.27 APE67-dihe-in -55.41, -25.98 -43.33, -53.94 APE12-dist-in 9.693 APE11-dist-in 8.524 APE10-dist-in 5.654 APE9-dist-in 4.069 None None None XRAY 2.5 0.222 0.249 A 326 274 0 0 0 0 [[38, 290]] 1.0 4jx3 CAMK_PIM1_HUMAN CAMK 4.7e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7OOVA P11309 33 305 313.0 No_ligand No_ligand Active DFGin 6.203 14.569 BLAminus DFGAsp-rot-in -122.84, 171.74 65.68, 80.45 198.23, -0.83 -90.31, 16.43 288.09, 76.06 -72.31, -11.34 in-in in 8.8 Saltbr-in 2.608 HRD-na-A -67.33, -47.42 68.65, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.94, 17.29 APE9-dihe-na -81.04, -164.98 APE8-dihe-in -82.61, 126.44 APE8-rot-in 309.83 APE67-dihe-in -78.03, -5.17 -57.01, -47.48 APE12-dist-in 9.512 APE11-dist-in 8.789 APE10-dist-in 5.486 APE9-dist-in 3.888 None None None XRAY 1.96 0.163 0.195 A 313 273 0 0 0 0 [[38, 290]] 1.0 7oov CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7OOWA P11309 33 305 313.0 No_ligand No_ligand Active DFGin 6.306 14.748 BLAminus DFGAsp-rot-in -122.68, 175.54 62.53, 73.89 197.55, 2.64 -87.93, 12.78 283.68, 73.03 -76.55, -12.97 in-in in 8.742 Saltbr-in 2.602 HRD-na-A -68.81, -49.98 73.35, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.14, 32.43 APE9-dihe-na -87.5, -147.91 APE8-dihe-in -98.97, 121.57 APE8-rot-in 305.26 APE67-dihe-in -77.55, -5.21 -53.13, -44.92 APE12-dist-in 9.593 APE11-dist-in 8.976 APE10-dist-in 5.575 APE9-dist-in 3.772 None None None XRAY 1.95 0.161 0.184 A 313 273 0 0 0 0 [[38, 290]] 1.0 7oow CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YHSA P11309 33 305 313.0 STU:306 Type1 Active DFGin 6.361 14.512 BLAminus DFGAsp-rot-in -129.35, 165.16 65.09, 87.92 192.4, 16.75 -99.2, 21.71 283.47, 69.45 -67.38, -11.76 in-in in 8.524 Saltbr-in 2.899 HRD-na-A -65.05, -49.56 68.79, 3.6 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 26.1 APE9-dihe-na -84.03, -156.82 APE8-dihe-in -85.78, 122.63 APE8-rot-in 304.34 APE67-dihe-in -62.69, -6.01 -56.85, -49.38 APE12-dist-in 9.327 APE11-dist-in 8.52 APE10-dist-in 5.508 APE9-dist-in 3.832 None SEP261 CME161,SEP261 XRAY 2.15 0.233 0.233 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yhs CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YI3A P11309 33 305 313.0 LY2:306 Type1 Active DFGin 6.292 14.764 BLAminus DFGAsp-rot-in -128.81, 164.98 60.01, 85.31 194.66, 0.14 -95.12, 30.71 287.86, 62.33 -66.19, -20.32 in-in in 7.795 Saltbr-in 2.733 HRD-na-A -63.25, -48.22 66.78, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.69, 36.2 APE9-dihe-na -99.79, -161.83 APE8-dihe-in -81.08, 117.39 APE8-rot-in 309.96 APE67-dihe-in -55.73, -11.01 -50.65, -56.8 APE12-dist-in 9.452 APE11-dist-in 8.685 APE10-dist-in 5.231 APE9-dist-in 4.019 None SEP261 CME161,SEP261 XRAY 2.5 0.208 0.259 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yi3 CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YI4A P11309 33 305 313.0 ADN:306 Type1 Active DFGin 6.072 14.698 BLAminus DFGAsp-rot-in -134.71, 164.97 59.13, 80.78 179.96, 50.34 -89.82, 21.93 287.09, 72.06 -64.68, -12.33 in-in in 8.788 Saltbr-in 2.717 HRD-na-A -68.53, -44.87 69.57, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.9, 36.65 APE9-dihe-na -82.94, -132.28 APE8-dihe-in -114.84, 117.13 APE8-rot-in 309.09 APE67-dihe-in -54.56, -19.23 -51.71, -52.26 APE12-dist-in 9.605 APE11-dist-in 8.674 APE10-dist-in 5.878 APE9-dist-in 4.182 None SEP261 CME161,SEP261 XRAY 2.4 0.21 0.246 A 273 269 4 0 0 0 [[38, 290]] 1.0 1yi4 CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3C4EA P11309 33 305 313.0 C4E:306 Type1 Active DFGin 6.021 14.776 BLAminus DFGAsp-rot-in -128.35, 166.0 69.48, 82.58 194.28, -2.59 -93.7, 21.6 286.61, 78.83 -72.51, -9.22 in-in in 8.886 Saltbr-in 2.732 HRD-na-A -67.91, -51.23 70.69, 5.52 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.94, 10.44 APE9-dihe-na -76.24, -163.31 APE8-dihe-in -81.86, 120.75 APE8-rot-in 311.66 APE67-dihe-in -66.61, -7.38 -59.14, -42.78 APE12-dist-in 9.659 APE11-dist-in 8.55 APE10-dist-in 5.176 APE9-dist-in 3.791 None None None XRAY 1.98 0.216 0.245 A 273 273 0 0 0 0 [[38, 290]] 1.0 3c4e CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3C4EB P11309 33 305 313.0 C4E:306 Type1 Active DFGin 6.075 14.791 BLAminus DFGAsp-rot-in -125.63, 166.99 68.65, 82.63 194.04, 7.36 -92.11, 15.76 285.08, 79.16 -64.7, -9.12 in-in in 8.873 Saltbr-in 2.937 HRD-na-A -73.69, -46.03 62.22, 13.94 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.74, 17.74 APE9-dihe-na -78.68, -151.78 APE8-dihe-in -92.25, 117.75 APE8-rot-in 301.9 APE67-dihe-in -69.85, -9.71 -53.08, -43.68 APE12-dist-in 9.738 APE11-dist-in 8.561 APE10-dist-in 5.43 APE9-dist-in 3.699 None None None XRAY 1.98 0.216 0.245 B 273 273 0 0 0 0 [[38, 290]] 1.0 3c4e CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3C4EC P11309 34 305 313.0 C4E:306 Type1 Active DFGin 6.06 14.765 BLAminus DFGAsp-rot-in -128.73, 171.78 61.45, 83.06 201.45, -4.86 -93.51, 22.09 285.2, 77.36 -74.45, -9.29 in-in in 9.024 Saltbr-in 2.46 HRD-na-A -74.89, -48.06 74.46, 0.4 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.43, 22.53 APE9-dihe-na -88.97, -156.05 APE8-dihe-in -88.82, 119.66 APE8-rot-in 306.87 APE67-dihe-in -73.65, -3.54 -57.42, -41.13 APE12-dist-in 9.701 APE11-dist-in 8.436 APE10-dist-in 5.166 APE9-dist-in 3.921 None None None XRAY 1.98 0.216 0.245 C 273 272 0 0 0 0 [[38, 290]] 1.0 3c4e CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3C4ED P11309 33 305 313.0 C4E:306 Type1 Active DFGin 6.309 14.709 BLAminus DFGAsp-rot-in -130.13, 172.88 59.98, 79.45 197.91, 5.13 -88.47, 15.36 281.95, 81.3 -75.02, -5.99 in-in in 8.79 Saltbr-in 2.443 HRD-na-A -70.24, -47.69 69.35, 4.35 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.82, 22.76 APE9-dihe-na -80.15, -163.14 APE8-dihe-in -81.97, 115.05 APE8-rot-in 309.18 APE67-dihe-in -70.46, -13.8 -51.69, -41.7 APE12-dist-in 9.726 APE11-dist-in 8.583 APE10-dist-in 5.506 APE9-dist-in 3.758 None None None XRAY 1.98 0.216 0.245 D 273 273 0 0 0 0 [[38, 290]] 1.0 3c4e CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4K1BA P11309 33 305 313.0 1OC:402 Type1 Active DFGin 6.043 14.613 BLAminus DFGAsp-rot-in -132.6, 164.86 70.11, 79.62 197.22, -7.8 -92.82, 21.53 288.39, 81.35 -65.25, -17.96 in-in in 8.856 Saltbr-in 2.632 HRD-na-A -70.69, -51.38 75.39, 5.68 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 19.78 APE9-dihe-na -83.3, -161.37 APE8-dihe-in -81.98, 126.09 APE8-rot-in 308.93 APE67-dihe-in -65.14, -9.59 -61.45, -45.63 APE12-dist-in 9.599 APE11-dist-in 8.678 APE10-dist-in 5.285 APE9-dist-in 3.823 None None None XRAY 2.082 0.172 0.199 A 273 273 0 0 0 0 [[38, 290]] 1.0 4k1b CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6NO8A P11309 33 305 313.0 KUY:401 Type1 Active DFGin 6.245 14.465 BLAminus DFGAsp-rot-in -136.93, 161.07 71.64, 80.45 188.1, 14.66 -96.46, 11.0 281.89, 88.38 -60.27, -17.64 in-in in 8.657 Saltbr-in 2.605 HRD-na-A -78.06, -49.34 70.05, 6.39 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.3, 11.35 APE9-dihe-na -78.95, -162.34 APE8-dihe-in -79.37, 127.44 APE8-rot-in 316.96 APE67-dihe-in -61.79, -7.22 -64.64, -48.15 APE12-dist-in 9.668 APE11-dist-in 8.777 APE10-dist-in 5.216 APE9-dist-in 3.794 None None None XRAY 2.377 0.187 0.232 A 273 273 0 0 0 0 [[38, 290]] 1.0 6no8 CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6NO9A P11309 33 305 313.0 KUV:504 Type1 Active DFGin 6.156 14.433 BLAminus DFGAsp-rot-in -126.34, 166.87 60.03, 83.92 188.24, 9.44 -89.43, 21.76 289.02, 78.21 -70.19, -16.22 in-in in 8.611 Saltbr-in 2.438 HRD-na-A -72.3, -46.64 69.8, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.26, 10.84 APE9-dihe-na -76.6, -153.49 APE8-dihe-in -92.15, 125.02 APE8-rot-in 306.25 APE67-dihe-in -69.76, -6.68 -64.44, -39.96 APE12-dist-in 9.679 APE11-dist-in 8.729 APE10-dist-in 5.081 APE9-dist-in 3.672 None None None XRAY 1.712 0.17 0.205 A 273 273 0 0 0 0 [[38, 290]] 1.0 6no9 CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4K0YA P11309 33 306 313.0 1OA:401 Type1 Active DFGin 6.292 14.389 BLAminus DFGAsp-rot-in -121.94, 171.4 62.4, 86.58 191.85, 12.15 -95.92, 17.62 287.73, 79.01 -70.57, -9.06 in-in in 8.904 Saltbr-in 2.509 HRD-na-A -73.78, -47.42 68.19, 7.19 in-in-in SNCiii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.37, 25.39 APE9-dihe-na -84.39, -155.13 APE8-dihe-in -90.58, 120.54 APE8-rot-in 303.27 APE67-dihe-in -71.06, -6.6 -61.16, -38.44 APE12-dist-in 9.671 APE11-dist-in 8.621 APE10-dist-in 5.549 APE9-dist-in 3.646 None None None XRAY 1.954 0.177 0.214 A 274 274 0 0 0 0 [[38, 290]] 1.0 4k0y CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5TEXA P11309 33 306 313.0 7AU:402 Type1 Active DFGin 6.01 14.829 BLAminus DFGAsp-rot-in -138.39, 174.01 63.47, 82.62 191.08, 21.19 -93.78, 16.92 290.32, 76.89 -70.47, -10.69 in-in in 9.269 Saltbr-in 2.845 HRD-na-A -75.68, -50.36 69.23, 7.58 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.29, 24.17 APE9-dihe-na -86.25, -152.07 APE8-dihe-in -90.77, 121.09 APE8-rot-in 307.82 APE67-dihe-in -67.29, -11.31 -64.01, -39.58 APE12-dist-in 9.692 APE11-dist-in 8.552 APE10-dist-in 5.404 APE9-dist-in 3.888 None None None XRAY 2.149 0.184 0.217 A 274 274 0 0 0 0 [[38, 290]] 1.0 5tex CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6VRUA P11309 34 306 313.0 ROY:402 Type1 Active DFGin 6.249 14.734 BLAminus DFGAsp-rot-in -126.97, 167.03 70.01, 79.24 209.65, -20.37 -93.65, 20.02 287.24, 69.33 -68.9, -13.34 in-in in 8.636 Saltbr-in 2.498 HRD-na-A -74.69, -47.82 68.45, 8.0 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.88, 21.88 APE9-dihe-na -81.69, -157.22 APE8-dihe-in -91.46, 126.79 APE8-rot-in 307.71 APE67-dihe-in -66.96, -7.81 -67.63, -41.62 APE12-dist-in 9.579 APE11-dist-in 8.574 APE10-dist-in 5.212 APE9-dist-in 3.706 None None None XRAY 2.07 0.179 0.202 A 274 273 0 0 0 0 [[38, 290]] 1.0 6vru CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6VRVA P11309 35 305 313.0 WFY:401 Type1 Active DFGin 6.31 14.775 BLAminus DFGAsp-rot-in -128.18, 168.1 70.4, 82.6 202.94, -33.16 -93.17, 16.82 287.59, 75.85 -67.39, -13.62 in-in in 8.776 Saltbr-in 2.527 HRD-na-A -73.57, -42.57 66.05, 10.02 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.71, 32.21 APE9-dihe-na -87.53, -152.73 APE8-dihe-in -95.97, 120.66 APE8-rot-in 293.39 APE67-dihe-in -72.79, -2.49 -61.51, -35.74 APE12-dist-in 9.572 APE11-dist-in 8.58 APE10-dist-in 5.675 APE9-dist-in 3.758 None None None XRAY 1.74 0.173 0.197 A 274 271 0 0 0 0 [[38, 290]] 1.0 6vrv CAMK_PIM1_HUMAN CAMK 2.5e-65 226.3 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4DTKA P11309 33 305 313.0 7LI:408 Type1 Active DFGin 6.142 14.661 BLAminus DFGAsp-rot-in -128.39, 173.69 63.23, 87.87 199.22, -2.97 -95.85, 17.29 285.67, 80.15 -64.1, -18.22 in-in in 8.861 Saltbr-in 2.588 HRD-na-A -66.25, -50.01 70.2, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.52, 26.77 APE9-dihe-na -86.23, -154.0 APE8-dihe-in -89.22, 120.59 APE8-rot-in 306.1 APE67-dihe-in -65.85, -11.4 -53.32, -45.84 APE12-dist-in 9.701 APE11-dist-in 8.585 APE10-dist-in 5.474 APE9-dist-in 3.692 None None None XRAY 1.86 0.166 0.182 A 276 273 0 0 0 0 [[38, 290]] 1.0 4dtk CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KGDA P11309 33 305 313.0 6SL:420 Type1 Active DFGin 6.194 14.598 BLAminus DFGAsp-rot-in -129.0, 173.16 59.49, 81.21 193.94, 14.65 -91.39, 15.51 283.61, 78.67 -67.75, -14.27 in-in in 8.818 Saltbr-in 2.725 HRD-na-A -68.62, -47.74 69.23, 3.07 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.77, 31.72 APE9-dihe-na -89.5, -153.75 APE8-dihe-in -91.96, 121.37 APE8-rot-in 309.6 APE67-dihe-in -67.17, -11.15 -55.07, -44.24 APE12-dist-in 9.602 APE11-dist-in 8.673 APE10-dist-in 5.606 APE9-dist-in 3.725 None None None XRAY 1.98 0.163 0.184 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kgd CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KGEA P11309 33 305 313.0 6SN:416 Type1 Active DFGin 6.186 14.607 BLAminus DFGAsp-rot-in -127.16, 171.98 58.94, 83.36 191.26, 18.15 -93.06, 16.77 283.0, 80.17 -66.19, -15.51 in-in in 8.801 Saltbr-in 2.666 HRD-na-A -68.2, -48.81 68.27, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.87, 31.34 APE9-dihe-na -88.89, -156.61 APE8-dihe-in -88.29, 120.88 APE8-rot-in 311.55 APE67-dihe-in -66.51, -12.56 -54.59, -43.9 APE12-dist-in 9.659 APE11-dist-in 8.694 APE10-dist-in 5.624 APE9-dist-in 3.745 None None None XRAY 2.23 0.196 0.208 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kge CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KGIA P11309 33 305 313.0 6SF:414 Type1 Active DFGin 6.196 14.678 BLAminus DFGAsp-rot-in -128.85, 173.72 58.37, 80.83 194.16, 16.54 -91.15, 15.65 283.15, 78.86 -67.29, -15.19 in-in in 8.898 Saltbr-in 2.699 HRD-na-A -66.85, -48.52 69.49, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.48, 30.3 APE9-dihe-na -88.67, -155.26 APE8-dihe-in -89.24, 121.14 APE8-rot-in 310.96 APE67-dihe-in -66.24, -12.88 -55.29, -44.34 APE12-dist-in 9.723 APE11-dist-in 8.735 APE10-dist-in 5.642 APE9-dist-in 3.74 None None None XRAY 2.13 0.173 0.186 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kgi CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KGKA P11309 33 305 313.0 6SD:407 Type1 Active DFGin 6.308 14.86 BLAminus DFGAsp-rot-in -128.4, 171.34 59.1, 83.1 193.0, 16.37 -92.34, 16.26 283.46, 79.02 -66.84, -16.78 in-in in 8.928 Saltbr-in 2.723 HRD-na-A -66.62, -48.72 69.73, 2.6 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.74, 32.55 APE9-dihe-na -90.23, -157.96 APE8-dihe-in -86.86, 120.62 APE8-rot-in 311.8 APE67-dihe-in -66.57, -13.56 -54.03, -44.15 APE12-dist-in 9.703 APE11-dist-in 8.85 APE10-dist-in 5.682 APE9-dist-in 3.763 None None None XRAY 2.66 0.188 0.206 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kgk CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6BSKA P11309 33 305 313.0 MVG:405 Type1 Active DFGin 6.106 14.526 BLAminus DFGAsp-rot-in -127.81, 171.26 61.28, 88.13 195.94, 2.94 -94.14, 14.55 285.4, 81.12 -65.15, -15.23 in-in in 8.733 Saltbr-in 2.653 HRD-na-A -65.0, -51.26 70.65, 3.06 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.1, 36.25 APE9-dihe-na -95.43, -156.67 APE8-dihe-in -85.65, 120.06 APE8-rot-in 311.62 APE67-dihe-in -68.39, -14.22 -55.35, -43.45 APE12-dist-in 9.802 APE11-dist-in 8.549 APE10-dist-in 5.636 APE9-dist-in 3.792 None None None XRAY 2.573 0.171 0.196 A 276 273 0 0 0 0 [[38, 290]] 1.0 6bsk CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4K18A P11309 32 308 313.0 1OB:402 Type1 Active DFGin 6.092 14.441 BLAminus DFGAsp-rot-in -127.16, 170.25 67.68, 77.49 190.42, 3.08 -90.65, 24.19 290.3, 84.83 -68.81, -16.15 in-in in 8.766 Saltbr-in 2.613 HRD-na-A -73.4, -51.44 75.59, 3.74 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.67, 18.39 APE9-dihe-na -83.8, -157.76 APE8-dihe-in -87.59, 123.77 APE8-rot-in 308.05 APE67-dihe-in -70.86, -5.11 -63.89, -39.96 APE12-dist-in 9.791 APE11-dist-in 8.803 APE10-dist-in 5.401 APE9-dist-in 3.925 None None None XRAY 2.051 0.186 0.22 A 277 277 0 0 0 0 [[38, 290]] 1.0 4k18 CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5IISA P11309 32 305 313.0 6CB:402 Type1 Active DFGin 6.388 14.757 BLAminus DFGAsp-rot-in -128.84, 173.3 61.28, 84.09 188.78, 15.68 -98.54, 16.15 284.91, 73.79 -69.44, -13.21 in-in in 8.28 Saltbr-in 2.701 HRD-na-A -69.32, -50.23 68.69, 7.8 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.03, 27.99 APE9-dihe-na -88.44, -153.73 APE8-dihe-in -93.14, 121.31 APE8-rot-in 307.37 APE67-dihe-in -67.36, -12.92 -53.81, -44.97 APE12-dist-in 9.471 APE11-dist-in 8.532 APE10-dist-in 5.269 APE9-dist-in 3.64 None SEP261 SEP261 XRAY 2.1 0.172 0.193 A 277 274 0 0 0 0 [[38, 290]] 1.0 5iis CAMK_PIM1_HUMAN CAMK 2.6e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4TY1A P11309 33 305 313.0 38W:401 Type1 Active DFGin 6.387 14.511 BLAminus DFGAsp-rot-in -133.05, 165.34 66.19, 78.61 190.44, -2.27 -90.98, 18.04 289.04, 69.92 -66.35, -17.07 in-in in 8.076 Saltbr-in 2.854 HRD-na-A -75.5, -52.3 76.47, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.39, -3.83 APE9-dihe-na -80.99, -152.88 APE8-dihe-in -92.77, 125.02 APE8-rot-in 308.7 APE67-dihe-in -59.27, -21.7 -50.58, -57.32 APE12-dist-in 9.55 APE11-dist-in 8.742 APE10-dist-in 4.367 APE9-dist-in 3.629 None None None XRAY 2.7 0.183 0.237 A 286 273 0 0 0 0 [[38, 290]] 1.0 4ty1 CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4WRSA P11309 33 305 313.0 3U1:403 Type1 Active DFGin 6.162 14.688 BLAminus DFGAsp-rot-in -131.19, 168.19 62.17, 84.39 189.74, 7.45 -94.94, 19.3 284.32, 75.21 -73.2, -12.05 in-in in 8.903 Saltbr-in 2.615 HRD-na-A -70.39, -48.07 69.42, 8.56 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.6, 16.03 APE9-dihe-na -86.28, -152.26 APE8-dihe-in -92.85, 128.8 APE8-rot-in 308.26 APE67-dihe-in -65.67, -10.81 -62.91, -47.38 APE12-dist-in 9.477 APE11-dist-in 8.618 APE10-dist-in 4.936 APE9-dist-in 3.763 None None None XRAY 2.2 0.18 0.208 A 286 273 0 0 0 0 [[38, 290]] 1.0 4wrs CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4WSYA P11309 33 305 313.0 3U5:401 Type1 Active DFGin 6.104 14.621 BLAminus DFGAsp-rot-in -127.31, -178.18 57.57, 65.12 227.03, -48.24 -84.25, 18.54 286.02, 73.35 -69.75, -14.58 in-in in 8.909 Saltbr-in 2.785 HRD-na-A -70.92, -47.77 70.77, 0.48 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.56, 17.45 APE9-dihe-na -80.04, -158.16 APE8-dihe-in -87.23, 129.67 APE8-rot-in 306.6 APE67-dihe-in -63.98, -11.76 -66.05, -47.25 APE12-dist-in 9.5 APE11-dist-in 8.578 APE10-dist-in 5.347 APE9-dist-in 3.795 None None None XRAY 2.3 0.184 0.224 A 286 273 0 0 0 0 [[38, 290]] 1.0 4wsy CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4WT6A P11309 33 305 313.0 3U6:401 Type1 Active DFGin 6.225 14.741 BLAminus DFGAsp-rot-in -129.31, 179.15 54.14, 72.7 198.93, 4.05 -88.4, 20.56 284.51, 71.19 -73.36, -15.22 in-in in 8.469 Saltbr-in 2.656 HRD-na-A -72.36, -44.25 65.88, 2.27 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.26, 22.96 APE9-dihe-na -91.6, -154.03 APE8-dihe-in -92.19, 127.1 APE8-rot-in 312.31 APE67-dihe-in -65.83, -13.24 -60.93, -48.29 APE12-dist-in 9.496 APE11-dist-in 8.613 APE10-dist-in 5.059 APE9-dist-in 3.998 None None None XRAY 2.3 0.178 0.211 A 286 273 0 0 0 0 [[38, 290]] 1.0 4wt6 CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5EOLA P11309 33 305 313.0 5QO:401 Type1 Active DFGin 6.256 14.631 BLAminus DFGAsp-rot-in -125.24, 171.83 59.51, 79.96 202.95, -5.23 -92.44, 22.49 285.02, 73.25 -70.93, -14.06 in-in in 8.763 Saltbr-in 2.573 HRD-na-A -73.1, -47.95 68.92, 3.14 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.99, 8.97 APE9-dihe-na -79.78, -148.56 APE8-dihe-in -97.04, 122.04 APE8-rot-in 309.05 APE67-dihe-in -66.69, -11.1 -58.67, -42.55 APE12-dist-in 9.583 APE11-dist-in 8.513 APE10-dist-in 4.913 APE9-dist-in 3.632 None None None XRAY 2.2 0.196 0.223 A 286 273 0 0 0 0 [[38, 290]] 1.0 5eol CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5IPJA P11309 33 305 313.0 6CD:401 Type1 Active DFGin 6.159 14.645 BLAminus DFGAsp-rot-in -129.06, 166.2 63.4, 89.79 200.51, -10.15 -98.28, 24.16 286.53, 74.98 -69.52, -15.68 in-in in 8.861 Saltbr-in 2.644 HRD-na-A -72.25, -47.9 67.86, 13.58 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.03, 18.83 APE9-dihe-na -86.4, -154.92 APE8-dihe-in -92.64, 123.62 APE8-rot-in 306.86 APE67-dihe-in -66.21, -11.28 -62.03, -43.15 APE12-dist-in 9.515 APE11-dist-in 8.525 APE10-dist-in 4.967 APE9-dist-in 3.594 None None None XRAY 2.1 0.181 0.221 A 286 273 0 0 0 0 [[38, 290]] 1.0 5ipj CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KZIA P11309 33 305 313.0 6YN:401 Type1 Active DFGin 6.232 14.459 BLAminus DFGAsp-rot-in -125.28, 171.61 59.7, 76.37 192.13, 5.81 -89.66, 23.41 287.5, 74.51 -76.32, -14.48 in-in in 8.563 Saltbr-in 2.622 HRD-na-A -74.51, -47.69 70.34, 4.33 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.16, 14.87 APE9-dihe-na -85.38, -150.81 APE8-dihe-in -98.45, 122.78 APE8-rot-in 307.97 APE67-dihe-in -69.43, -12.03 -61.1, -42.73 APE12-dist-in 9.623 APE11-dist-in 8.712 APE10-dist-in 4.944 APE9-dist-in 3.81 None None None XRAY 2.1 0.179 0.205 A 286 273 0 0 0 0 [[38, 290]] 1.0 5kzi CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6MT0A P11309 33 305 313.0 JYG:401 Type1 Active DFGin 6.18 14.644 BLAminus DFGAsp-rot-in -129.1, 162.88 69.48, 92.17 199.83, -19.03 -101.8, 22.17 287.32, 75.1 -69.24, -17.14 in-in in 8.667 Saltbr-in 2.729 HRD-na-A -70.67, -47.42 66.78, 12.82 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.16, 8.39 APE9-dihe-na -79.87, -163.75 APE8-dihe-in -86.85, 127.4 APE8-rot-in 308.59 APE67-dihe-in -66.88, -11.27 -60.5, -47.04 APE12-dist-in 9.377 APE11-dist-in 8.553 APE10-dist-in 4.612 APE9-dist-in 3.544 None None None XRAY 2.2 0.18 0.208 A 286 273 0 0 0 0 [[38, 290]] 1.0 6mt0 CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4MTAA P11309 33 305 313.0 2D2:401 Type1 Active DFGin 6.276 14.337 BLAminus DFGAsp-rot-in -121.41, 177.86 55.53, 82.62 194.54, 10.59 -93.46, 16.76 281.52, 74.78 -72.09, -10.86 in-in in 8.719 Saltbr-in 2.611 HRD-na-A -62.2, -48.48 67.49, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.11, 24.3 APE9-dihe-na -85.34, -152.54 APE8-dihe-in -92.96, 123.11 APE8-rot-in 306.26 APE67-dihe-in -67.9, -13.27 -54.99, -44.77 APE12-dist-in 9.528 APE11-dist-in 8.516 APE10-dist-in 5.416 APE9-dist-in 3.575 None None None XRAY 2.2 0.16 0.192 A 286 273 0 0 0 0 [[38, 290]] 1.0 4mta CAMK_PIM1_HUMAN CAMK 3e-65 226.1 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5C1QB P11309 33 305 313.0 4YK:401 Type1 Active DFGin 5.891 13.333 BLAminus DFGAsp-rot-in -134.33, 156.38 72.1, 106.74 195.18, 35.54 -112.64, 17.25 301.94, 90.76 -59.71, -41.8 in-in in 8.621 Saltbr-in 2.593 HRD-na-A -64.46, -50.63 69.52, -24.55 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.39, 56.57 APE9-dihe-na -121.47, -173.24 APE8-dihe-in -77.48, 148.97 APE8-rot-in 348.38 APE67-dihe-in -42.36, -34.75 -61.79, -66.84 APE12-dist-in 9.406 APE11-dist-in 8.252 APE10-dist-in 5.377 APE9-dist-in 4.926 None None None XRAY 3.0 0.178 0.246 B 289 273 0 0 0 0 [[38, 290]] 1.0 5c1q CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L11A P11309 33 305 313.0 E2C:401 Type1 Active DFGin 6.163 14.967 BLAminus DFGAsp-rot-in -125.67, 168.03 67.88, 78.16 200.42, -7.98 -84.6, 16.39 285.76, 87.64 -71.05, -19.61 in-in in 8.996 Saltbr-in 2.702 HRD-na-A -66.89, -52.69 70.36, 8.44 in-in-in SNCiii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.89, 29.6 APE9-dihe-na -84.12, -156.34 APE8-dihe-in -92.4, 128.66 APE8-rot-in 306.74 APE67-dihe-in -67.11, -6.47 -60.7, -48.56 APE12-dist-in 9.356 APE11-dist-in 8.386 APE10-dist-in 5.431 APE9-dist-in 3.709 None SEP261 SEP261 XRAY 2.05 0.214 0.24 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l11 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L12A P11309 33 305 313.0 E2R:401 Type1 Active DFGin 6.216 14.703 BLAminus DFGAsp-rot-in -127.05, 170.42 68.23, 81.09 196.25, 0.5 -92.51, 16.44 287.76, 81.55 -64.97, -20.04 in-in in 8.983 Saltbr-in 2.722 HRD-na-A -72.18, -48.09 70.82, 3.37 in-in-in SNCiii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.36, 18.6 APE9-dihe-na -85.64, -160.05 APE8-dihe-in -87.61, 125.01 APE8-rot-in 307.11 APE67-dihe-in -68.37, -12.11 -58.28, -46.28 APE12-dist-in 9.378 APE11-dist-in 8.581 APE10-dist-in 5.06 APE9-dist-in 3.833 None SEP261 SEP261 XRAY 1.87 0.197 0.21 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l12 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A P11309 33 305 313.0 E2F:401 Type1 Active DFGin 6.19 14.786 BLAminus DFGAsp-rot-in -130.24, 168.2 68.46, 80.68 194.95, 3.78 -89.17, 16.05 288.1, 80.31 -69.01, -19.61 in-in in 9.105 Saltbr-in 2.936 HRD-na-A -68.46, -51.8 71.9, 8.52 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 29.56 APE9-dihe-na -92.34, -153.25 APE8-dihe-in -98.43, 124.2 APE8-rot-in 303.55 APE67-dihe-in -68.48, -12.49 -58.68, -45.06 APE12-dist-in 9.5 APE11-dist-in 8.511 APE10-dist-in 5.099 APE9-dist-in 3.659 None SEP261 SEP261 XRAY 2.24 0.18 0.214 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l13 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L14A P11309 33 305 313.0 E2L:401 Type1 Active DFGin 6.201 14.894 BLAminus DFGAsp-rot-in -126.69, 169.11 67.27, 79.53 197.56, -7.54 -86.62, 19.33 288.75, 82.28 -66.99, -22.84 in-in in 9.045 Saltbr-in 2.836 HRD-na-A -67.72, -50.1 68.21, 9.79 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.83, 24.46 APE9-dihe-na -89.25, -158.62 APE8-dihe-in -92.28, 125.41 APE8-rot-in 306.06 APE67-dihe-in -68.05, -12.07 -60.25, -45.14 APE12-dist-in 9.509 APE11-dist-in 8.518 APE10-dist-in 5.074 APE9-dist-in 3.771 None SEP261 SEP261 XRAY 1.95 0.193 0.209 A 289 271 2 0 0 0 [[38, 290]] 1.0 6l14 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L15A P11309 33 305 313.0 E2O:401 Type1 Active DFGin 6.35 14.598 BLAminus DFGAsp-rot-in -131.83, 163.47 71.59, 79.35 198.74, -5.36 -89.78, 14.2 284.41, 77.37 -65.48, -21.82 in-in in 8.235 Saltbr-in 2.566 HRD-na-A -64.16, -54.27 75.51, 4.04 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.69, 27.17 APE9-dihe-na -98.51, -154.05 APE8-dihe-in -93.58, 128.93 APE8-rot-in 316.57 APE67-dihe-in -60.96, -21.44 -58.79, -53.8 APE12-dist-in 9.407 APE11-dist-in 8.636 APE10-dist-in 4.929 APE9-dist-in 3.916 None SEP261 SEP261 XRAY 2.6 0.184 0.221 A 289 270 3 0 0 0 [[38, 290]] 1.0 6l15 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L16A P11309 33 305 313.0 E2U:401 Type1 Active DFGin 6.328 14.74 BLAminus DFGAsp-rot-in -130.86, 166.29 65.26, 82.88 194.99, 0.98 -91.87, 18.01 283.01, 76.97 -72.19, -13.53 in-in in 8.702 Saltbr-in 2.415 HRD-na-A -67.28, -47.47 67.45, 11.65 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.92, 16.39 APE9-dihe-na -84.74, -155.75 APE8-dihe-in -95.92, 129.43 APE8-rot-in 310.51 APE67-dihe-in -64.98, -15.76 -62.83, -46.58 APE12-dist-in 9.31 APE11-dist-in 8.521 APE10-dist-in 4.739 APE9-dist-in 3.778 None SEP261 SEP261 XRAY 2.1 0.199 0.218 A 289 270 3 0 0 0 [[38, 290]] 1.0 6l16 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L17A P11309 33 305 313.0 E2X:401 Type1 Active DFGin 6.324 14.653 BLAminus DFGAsp-rot-in -129.55, 165.34 65.87, 81.97 196.2, -5.76 -92.53, 17.46 286.99, 73.6 -66.81, -14.75 in-in in 8.398 Saltbr-in 2.601 HRD-na-A -68.49, -49.87 68.95, 13.18 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.96, 18.29 APE9-dihe-na -82.73, -153.32 APE8-dihe-in -94.04, 120.15 APE8-rot-in 303.42 APE67-dihe-in -68.29, -9.26 -56.68, -41.93 APE12-dist-in 9.511 APE11-dist-in 8.559 APE10-dist-in 5.224 APE9-dist-in 3.7 None SEP261 SEP261 XRAY 1.75 0.185 0.205 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l17 CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7XSVA P11309 32 305 313.0 I4M:401 Type1 Active DFGin 6.058 14.317 BLAminus DFGAsp-rot-in -136.35, 175.71 54.46, 80.4 204.2, 14.5 -90.61, 15.51 289.45, 76.26 -61.12, -29.45 in-in in 8.167 Saltbr-in 2.487 HRD-na-A -80.1, -41.91 69.45, -9.52 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.82, 18.64 APE9-dihe-na -91.64, 171.14 APE8-dihe-in -71.59, 144.23 APE8-rot-in 295.24 APE67-dihe-in -74.83, -31.12 -57.05, -23.4 APE12-dist-in 8.859 APE11-dist-in 8.426 APE10-dist-in 4.63 APE9-dist-in 4.818 None SEP261 SEP261 XRAY 2.66 0.197 0.233 A 289 274 0 0 0 0 [[38, 290]] 1.0 7xsv CAMK_PIM1_HUMAN CAMK 3.1e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5KCXA P11309 34 305 313.0 6S3:403 Type1 Active DFGin 6.221 14.917 BLAminus DFGAsp-rot-in -132.88, 167.48 63.01, 80.22 200.14, -1.04 -91.16, 17.8 283.48, 68.85 -71.72, -7.39 in-in in 8.848 Saltbr-in 2.523 HRD-na-A -73.28, -48.22 75.07, 1.67 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.64, 15.26 APE9-dihe-na -83.36, -157.62 APE8-dihe-in -86.75, 121.87 APE8-rot-in 307.36 APE67-dihe-in -65.54, -9.34 -59.93, -45.42 APE12-dist-in 9.648 APE11-dist-in 8.609 APE10-dist-in 5.252 APE9-dist-in 3.864 None None None XRAY 2.2 0.19 0.211 A 291 272 0 0 0 0 [[38, 290]] 1.0 5kcx CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4MBLA P11309 33 306 313.0 26L:401 Type1 Active DFGin 6.357 14.647 BLAminus DFGAsp-rot-in -140.97, 162.32 61.82, 87.23 195.27, 28.32 -100.32, 23.61 288.64, 85.04 -75.88, -10.71 in-in in 8.463 Saltbr-in 2.705 HRD-na-A -66.61, -53.32 68.87, 14.83 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.99, 40.01 APE9-dihe-na -114.3, -171.32 APE8-dihe-in -75.76, 118.27 APE8-rot-in 314.72 APE67-dihe-in -58.14, -19.65 -55.56, -49.63 APE12-dist-in 9.033 APE11-dist-in 8.658 APE10-dist-in 4.882 APE9-dist-in 4.191 None None None XRAY 2.6 0.202 0.242 A 293 274 0 0 0 0 [[38, 290]] 1.0 4mbl CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXVA P11309 33 306 313.0 LI6:323 Type1 Active DFGin 6.153 14.62 BLAminus DFGAsp-rot-in -131.19, 171.32 56.28, 85.76 194.48, 23.18 -94.29, 14.73 284.91, 75.06 -64.34, -11.63 in-in in 8.893 Saltbr-in 2.542 HRD-na-A -66.61, -47.26 65.08, 9.89 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.55, 31.12 APE9-dihe-na -89.85, -157.25 APE8-dihe-in -87.05, 122.1 APE8-rot-in 305.25 APE67-dihe-in -67.3, -11.88 -57.54, -43.12 APE12-dist-in 9.697 APE11-dist-in 8.49 APE10-dist-in 5.438 APE9-dist-in 3.736 None None None XRAY 2.0 0.189 0.211 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxv CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1YXXA P11309 33 306 313.0 LI7:323 Type1 Active DFGin 6.164 14.435 BLAminus DFGAsp-rot-in -118.82, 172.49 62.96, 83.76 197.35, -4.57 -93.84, 24.35 282.94, 80.67 -77.24, -2.76 in-in in 8.874 Saltbr-in 2.446 HRD-na-A -72.3, -43.39 62.78, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.23, 43.27 APE9-dihe-na -100.31, -154.93 APE8-dihe-in -89.78, 124.47 APE8-rot-in 309.92 APE67-dihe-in -69.42, -9.61 -60.64, -40.01 APE12-dist-in 9.744 APE11-dist-in 8.405 APE10-dist-in 5.643 APE9-dist-in 3.801 None None None XRAY 2.0 0.219 0.251 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxx CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O3PA P11309 33 306 313.0 QUE:501 Type1 Active DFGin 6.238 14.536 BLAminus DFGAsp-rot-in -130.88, 170.78 53.54, 90.02 191.64, 32.83 -97.28, 20.48 282.33, 78.83 -71.95, -12.75 in-in in 8.667 Saltbr-in 2.296 HRD-na-A -68.04, -46.2 63.08, 8.81 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.42, 29.49 APE9-dihe-na -90.86, -153.23 APE8-dihe-in -86.96, 125.45 APE8-rot-in 306.17 APE67-dihe-in -64.91, -8.64 -61.09, -46.67 APE12-dist-in 9.661 APE11-dist-in 8.531 APE10-dist-in 5.429 APE9-dist-in 3.848 None None None XRAY 2.24 0.189 0.22 A 293 274 0 0 0 0 [[38, 290]] 1.0 2o3p CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O64A P11309 33 306 313.0 MYU:501 Type1 Active DFGin 6.271 14.675 BLAminus DFGAsp-rot-in -128.75, 172.17 61.57, 79.87 189.4, 15.88 -92.44, 15.52 285.23, 76.88 -62.99, -16.57 in-in in 8.412 Saltbr-in 2.672 HRD-na-A -65.21, -51.23 71.84, 4.17 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.67, 34.14 APE9-dihe-na -99.78, -147.67 APE8-dihe-in -92.72, 124.85 APE8-rot-in 309.85 APE67-dihe-in -64.3, -15.3 -61.26, -48.06 APE12-dist-in 9.606 APE11-dist-in 8.584 APE10-dist-in 5.419 APE9-dist-in 3.948 None None None XRAY 2.44 0.191 0.23 A 293 274 0 0 0 0 [[38, 290]] 1.0 2o64 CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A P11309 33 306 313.0 MYF:501 Type1 Active DFGin 5.773 14.223 BLAminus DFGAsp-rot-in -134.9, 170.04 60.08, 89.22 197.66, 11.39 -101.35, 10.62 287.34, 92.73 -63.96, -9.9 in-in in 8.704 Saltbr-in 2.471 HRD-na-A -65.14, -47.59 70.03, -4.07 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 34.64 APE9-dihe-na -104.35, -148.26 APE8-dihe-in -83.11, 121.1 APE8-rot-in 316.59 APE67-dihe-in -62.15, -16.44 -57.04, -47.52 APE12-dist-in 9.988 APE11-dist-in 8.628 APE10-dist-in 5.289 APE9-dist-in 4.136 None None None XRAY 2.85 0.21 0.262 A 293 274 0 0 0 0 [[38, 290]] 1.0 2o65 CAMK_PIM1_HUMAN CAMK 3.3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3JXWA P11309 33 306 313.0 LXG:1000 Type1 Active DFGin 6.21 14.597 BLAminus DFGAsp-rot-in -134.41, 162.67 73.18, 86.78 202.04, -24.59 -94.42, 16.28 283.72, 78.67 -67.2, -7.05 in-in in 8.943 Saltbr-in 2.764 HRD-na-A -66.64, -45.65 67.32, 6.42 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.1, 39.58 APE9-dihe-na -109.74, -153.05 APE8-dihe-in -85.54, 118.8 APE8-rot-in 317.48 APE67-dihe-in -60.88, -20.58 -50.76, -58.31 APE12-dist-in 9.527 APE11-dist-in 8.545 APE10-dist-in 5.492 APE9-dist-in 4.256 None None None XRAY 2.8 0.219 0.266 A 294 274 0 0 0 0 [[38, 290]] 1.0 3jxw CAMK_PIM1_HUMAN CAMK 3.3e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3JY0A P11309 33 307 313.0 LYG:1000 Type1 Active DFGin 5.965 14.459 BLAminus DFGAsp-rot-in -136.0, 169.05 67.14, 86.13 197.06, -23.2 -88.57, 12.42 285.25, 84.28 -62.59, -9.01 in-in in 8.897 Saltbr-in 2.579 HRD-na-A -73.59, -52.32 72.38, 9.82 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.33, 17.31 APE9-dihe-na -90.28, -146.77 APE8-dihe-in -93.89, 122.92 APE8-rot-in 318.19 APE67-dihe-in -68.56, -0.09 -56.36, -49.84 APE12-dist-in 9.762 APE11-dist-in 8.491 APE10-dist-in 4.971 APE9-dist-in 3.801 None None None XRAY 2.4 0.226 0.257 A 294 275 0 0 0 0 [[38, 290]] 1.0 3jy0 CAMK_PIM1_HUMAN CAMK 3.3e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3JYAA P11309 33 306 313.0 LWG:1000 Type1 Active DFGin 6.21 14.511 BLAminus DFGAsp-rot-in -132.92, 173.52 45.25, 85.32 192.81, 39.32 -90.21, 14.37 285.74, 75.57 -67.67, -13.84 in-in in 9.062 Saltbr-in 2.473 HRD-na-A -71.42, -47.46 64.92, 10.13 in-in-in SNCiii in-in ActLoopNT-in 2.706 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.34, 26.83 APE9-dihe-na -88.37, -156.09 APE8-dihe-in -89.17, 119.95 APE8-rot-in 305.54 APE67-dihe-in -68.16, -12.31 -55.92, -42.85 APE12-dist-in 9.54 APE11-dist-in 8.496 APE10-dist-in 5.391 APE9-dist-in 3.751 None None None XRAY 2.1 0.234 0.257 A 294 274 0 0 0 0 [[38, 290]] 1.0 3jya CAMK_PIM1_HUMAN CAMK 3.3e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5O11A P11309 34 305 313.0 3NG:401 Type1 Active DFGin 6.128 14.611 BLAminus DFGAsp-rot-in -127.88, 174.91 62.14, 80.5 183.46, 5.1 -88.8, 17.09 290.86, 80.03 -61.06, -19.7 in-in in 8.856 Saltbr-in 2.607 HRD-na-A -68.12, -50.16 69.42, 1.48 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.35, 8.9 APE9-dihe-na -86.78, -150.83 APE8-dihe-in -93.81, 133.37 APE8-rot-in 308.93 APE67-dihe-in -69.86, -10.11 -67.48, -44.09 APE12-dist-in 9.742 APE11-dist-in 8.73 APE10-dist-in 4.861 APE9-dist-in 3.817 None SEP261 CME161,SEP261 XRAY 2.4 0.167 0.212 A 298 270 2 0 0 0 [[38, 290]] 1.0 5o11 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5O12A P11309 34 305 313.0 1RO:401 Type1 Active DFGin 6.232 14.5 BLAminus DFGAsp-rot-in -126.26, 172.57 61.88, 84.82 190.06, 4.72 -89.13, 24.53 288.01, 80.82 -77.95, -15.0 in-in in 8.881 Saltbr-in 2.7 HRD-na-A -70.16, -50.1 71.34, 2.69 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.86, 30.76 APE9-dihe-na -86.98, -148.45 APE8-dihe-in -99.72, 127.71 APE8-rot-in 312.69 APE67-dihe-in -67.78, -9.89 -65.97, -45.8 APE12-dist-in 9.516 APE11-dist-in 8.446 APE10-dist-in 5.651 APE9-dist-in 3.718 None SEP261 CME161,SEP261 XRAY 2.4 0.179 0.223 A 298 266 6 0 0 0 [[38, 290]] 1.0 5o12 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5O13A P11309 34 305 313.0 9G5:401 Type1 Active DFGin 6.232 14.57 BLAminus DFGAsp-rot-in -126.22, 173.43 61.18, 82.34 193.26, 21.16 -90.65, 15.63 288.81, 77.08 -66.25, -16.88 in-in in 8.808 Saltbr-in 2.621 HRD-na-A -66.53, -48.7 66.86, 2.99 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.42, 11.87 APE9-dihe-na -70.23, -134.62 APE8-dihe-in -110.38, 131.64 APE8-rot-in 317.06 APE67-dihe-in -70.9, -10.23 -68.47, -45.42 APE12-dist-in 9.682 APE11-dist-in 8.543 APE10-dist-in 5.438 APE9-dist-in 4.062 None SEP261 CSX161,SEP261 XRAY 2.44 0.162 0.214 A 298 272 0 0 0 0 [[38, 290]] 1.0 5o13 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5DGZA P11309 33 305 313.0 L20:401 Type1 Active DFGin 6.328 14.841 BLAminus DFGAsp-rot-in -128.71, 169.75 60.97, 88.72 187.33, 17.72 -102.55, 22.85 284.63, 77.63 -73.84, -14.69 in-in in 8.57 Saltbr-in 2.539 HRD-na-A -79.61, -44.74 68.32, 8.97 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.12, 19.6 APE9-dihe-na -84.49, -168.79 APE8-dihe-in -78.12, 137.4 APE8-rot-in 353.29 APE67-dihe-in -67.56, -8.39 -54.96, -54.27 APE12-dist-in 9.482 APE11-dist-in 8.792 APE10-dist-in 5.09 APE9-dist-in 3.869 None None None XRAY 2.502 0.182 0.213 A 299 273 0 0 0 0 [[38, 290]] 1.0 5dgz CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5DHJA P11309 33 305 313.0 5E5:401 Type1 Active DFGin 6.277 14.641 BLAminus DFGAsp-rot-in -132.48, 165.98 68.77, 75.26 195.0, -1.34 -89.6, 23.34 285.29, 75.18 -66.63, -15.53 in-in in 8.678 Saltbr-in 2.6 HRD-na-A -74.9, -49.69 73.89, 5.62 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.14, 28.7 APE9-dihe-na -93.46, -149.0 APE8-dihe-in -88.51, 125.57 APE8-rot-in 319.11 APE67-dihe-in -63.27, -9.53 -60.93, -48.3 APE12-dist-in 9.69 APE11-dist-in 8.709 APE10-dist-in 5.576 APE9-dist-in 3.889 None None None XRAY 2.457 0.191 0.25 A 299 273 0 0 0 0 [[38, 290]] 1.0 5dhj CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5DIAA P11309 33 305 313.0 5E6:401 Type1 Active DFGin 6.109 14.364 BLAminus DFGAsp-rot-in -131.51, 162.73 65.64, 95.79 188.54, 16.54 -106.0, 22.43 288.31, 75.68 -70.61, -13.53 in-in in 8.893 Saltbr-in 2.663 HRD-na-A -70.21, -53.43 79.23, -0.98 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.54, 25.72 APE9-dihe-na -78.57, -156.72 APE8-dihe-in -91.47, 121.1 APE8-rot-in 309.49 APE67-dihe-in -70.58, -6.62 -58.72, -40.2 APE12-dist-in 9.6 APE11-dist-in 8.649 APE10-dist-in 5.487 APE9-dist-in 3.767 None None None XRAY 1.964 0.198 0.229 A 299 273 0 0 0 0 [[38, 290]] 1.0 5dia CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5V80A P11309 33 305 313.0 971:402 Type1 Active DFGin 6.293 14.711 BLAminus DFGAsp-rot-in -125.21, 168.1 67.15, 84.62 186.17, 12.1 -97.5, 21.56 283.85, 73.58 -74.5, -9.73 in-in in 8.823 Saltbr-in 2.489 HRD-na-A -71.2, -48.76 73.46, -4.54 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.28, 17.28 APE9-dihe-na -81.45, -156.95 APE8-dihe-in -91.64, 124.53 APE8-rot-in 310.44 APE67-dihe-in -65.24, -8.9 -57.42, -46.72 APE12-dist-in 9.621 APE11-dist-in 8.702 APE10-dist-in 5.196 APE9-dist-in 3.924 None None None XRAY 2.252 0.177 0.212 A 299 273 0 0 0 0 [[38, 290]] 1.0 5v80 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5V82A P11309 34 306 313.0 96Y:401 Type1 Active DFGin 6.213 14.412 BLAminus DFGAsp-rot-in -125.78, 171.27 64.15, 78.85 195.53, 7.28 -91.71, 19.69 286.42, 77.38 -68.31, -20.73 in-in in 8.824 Saltbr-in 2.571 HRD-na-A -70.88, -47.55 68.67, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.07, 17.68 APE9-dihe-na -81.71, -152.79 APE8-dihe-in -94.55, 121.67 APE8-rot-in 301.55 APE67-dihe-in -68.27, -8.9 -60.36, -41.63 APE12-dist-in 9.743 APE11-dist-in 8.674 APE10-dist-in 5.183 APE9-dist-in 3.586 None None None XRAY 1.888 0.182 0.199 A 299 273 0 0 0 0 [[38, 290]] 1.0 5v82 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3UIXA P11309 37 305 313.0 Q17:400 Type1 Active DFGin 6.159 14.821 BLAminus DFGAsp-rot-in -133.2, 170.02 65.66, 77.49 195.62, 6.12 -86.97, 13.03 288.74, 81.94 -68.85, -14.59 in-in in 9.065 Saltbr-in 2.885 HRD-na-A -68.2, -50.15 66.82, 5.77 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.4, 30.15 APE9-dihe-na -90.24, -149.24 APE8-dihe-in -93.32, 120.98 APE8-rot-in 306.79 APE67-dihe-in -70.28, -11.9 -58.72, -40.96 APE12-dist-in 9.606 APE11-dist-in 8.524 APE10-dist-in 5.489 APE9-dist-in 3.756 None None None XRAY 2.2 0.168 0.201 A 298 266 3 0 0 0 [[38, 290]] 1.0 3uix CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3UMWA P11309 37 304 313.0 596:400 Type1 Active DFGin 6.291 14.584 BLAminus DFGAsp-rot-in -128.68, 168.78 67.21, 80.33 190.12, 4.69 -91.49, 18.98 287.81, 74.46 -67.02, -11.8 in-in in 8.489 Saltbr-in 2.85 HRD-na-A -69.92, -48.57 70.74, 4.13 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.82, 23.54 APE9-dihe-na -81.68, -155.27 APE8-dihe-in -92.32, 121.26 APE8-rot-in 306.5 APE67-dihe-in -69.25, -11.28 -53.65, -48.44 APE12-dist-in 9.154 APE11-dist-in 8.563 APE10-dist-in 5.552 APE9-dist-in 3.772 None None None XRAY 2.08 0.175 0.2 A 298 264 4 0 0 0 [[38, 290]] 1.0 3umw CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3UMXA P11309 37 304 313.0 Q18:400 Type1 Active DFGin 6.321 14.693 BLAminus DFGAsp-rot-in -128.18, 168.05 66.13, 83.77 180.57, 23.99 -95.39, 17.61 280.32, 78.57 -66.8, -16.44 in-in in 8.436 Saltbr-in 2.952 HRD-na-A -70.86, -46.1 72.14, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.18, 34.19 APE9-dihe-na -90.9, -156.14 APE8-dihe-in -92.65, 120.83 APE8-rot-in 316.33 APE67-dihe-in -56.49, -20.39 -55.25, -56.16 APE12-dist-in 9.018 APE11-dist-in 8.613 APE10-dist-in 5.466 APE9-dist-in 3.943 None None None XRAY 2.55 0.18 0.229 A 298 261 7 0 0 0 [[38, 290]] 1.0 3umx CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4ENXA P11309 37 305 313.0 Z20:402 Type1 Active DFGin 6.072 14.258 BLAminus DFGAsp-rot-in -124.23, 174.95 56.93, 87.82 196.14, 25.37 -99.36, 21.71 285.95, 80.74 -78.01, -5.47 in-in in 8.792 Saltbr-in 2.47 HRD-na-A -68.51, -45.47 67.84, 12.31 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.34, 41.24 APE9-dihe-na -101.41, -153.2 APE8-dihe-in -90.61, 127.01 APE8-rot-in 310.22 APE67-dihe-in -64.59, -15.43 -67.29, -43.92 APE12-dist-in 9.234 APE11-dist-in 8.662 APE10-dist-in 5.421 APE9-dist-in 3.737 None None None XRAY 2.8 0.192 0.233 A 298 266 3 0 0 0 [[38, 290]] 1.0 4enx CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4ENYA P11309 37 305 313.0 J19:404 Type1 Active DFGin 6.168 14.409 BLAminus DFGAsp-rot-in -126.77, 176.31 56.15, 81.83 189.57, 21.96 -92.01, 22.92 285.19, 76.91 -75.2, -11.55 in-in in 8.812 Saltbr-in 2.674 HRD-na-A -67.09, -45.67 67.16, 8.93 in-in-in SNCiii in-in ActLoopNT-in 2.758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.12, 33.6 APE9-dihe-na -103.74, -163.7 APE8-dihe-in -76.76, 123.85 APE8-rot-in 309.22 APE67-dihe-in -67.99, -11.42 -63.9, -43.13 APE12-dist-in 9.454 APE11-dist-in 8.668 APE10-dist-in 5.209 APE9-dist-in 3.81 None None None XRAY 2.801 0.175 0.224 A 298 261 8 0 0 0 [[38, 290]] 1.0 4eny CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4LL5A P11309 34 305 313.0 SK8:401 Type1 Active DFGin 6.154 14.941 BLAminus DFGAsp-rot-in -130.09, 167.4 64.64, 85.24 199.15, 5.95 -96.78, 19.13 285.46, 79.08 -67.1, -17.77 in-in in 8.905 Saltbr-in 2.907 HRD-na-A -72.89, -48.94 71.1, 5.66 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.97, 33.17 APE9-dihe-na -91.19, -159.67 APE8-dihe-in -86.75, 127.22 APE8-rot-in 309.08 APE67-dihe-in -69.44, -9.3 -64.52, -42.1 APE12-dist-in 9.593 APE11-dist-in 8.625 APE10-dist-in 5.503 APE9-dist-in 3.723 None None None XRAY 2.0 0.169 0.189 A 298 268 4 0 0 0 [[38, 290]] 1.0 4ll5 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4LM5A P11309 35 305 313.0 Q17:401 Type1 Active DFGin 6.172 14.847 BLAminus DFGAsp-rot-in -129.33, 170.23 65.43, 81.43 200.33, 0.23 -93.64, 15.07 286.04, 82.64 -63.86, -18.24 in-in in 9.134 Saltbr-in 2.731 HRD-na-A -69.11, -47.25 68.05, 2.81 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.68, 24.87 APE9-dihe-na -83.15, -151.88 APE8-dihe-in -95.39, 124.37 APE8-rot-in 310.14 APE67-dihe-in -64.57, -11.11 -60.82, -46.98 APE12-dist-in 9.51 APE11-dist-in 8.515 APE10-dist-in 5.423 APE9-dist-in 3.713 None None CSO161 XRAY 2.25 0.158 0.198 A 298 265 6 0 0 0 [[38, 290]] 1.0 4lm5 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4LMUA P11309 36 304 313.0 QUE:401 Type1 Active DFGin 6.162 14.431 BLAminus DFGAsp-rot-in -125.85, 174.43 58.26, 85.32 196.23, 12.85 -97.42, 18.39 285.76, 76.14 -68.38, -9.73 in-in in 8.702 Saltbr-in 2.385 HRD-na-A -71.42, -45.75 68.18, 3.07 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 30.35 APE9-dihe-na -86.53, -151.77 APE8-dihe-in -97.13, 122.66 APE8-rot-in 306.98 APE67-dihe-in -65.32, -7.73 -59.99, -46.55 APE12-dist-in 9.452 APE11-dist-in 8.617 APE10-dist-in 5.514 APE9-dist-in 3.834 None None None XRAY 2.38 0.172 0.204 A 298 265 4 0 0 0 [[38, 290]] 1.0 4lmu CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5VUAB P11309 36 305 313.0 8GX:403 Type1 Active DFGin 6.267 14.631 BLAminus DFGAsp-rot-in -131.5, 169.5 65.68, 85.46 192.36, 5.25 -98.43, 24.84 284.2, 75.16 -72.94, -9.76 in-in in 8.454 Saltbr-in 2.841 HRD-na-A -72.0, -46.73 70.73, 2.09 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.51, 33.95 APE9-dihe-na -87.15, -156.37 APE8-dihe-in -92.0, 123.34 APE8-rot-in 311.17 APE67-dihe-in -66.19, -11.92 -56.69, -48.02 APE12-dist-in 9.264 APE11-dist-in 8.543 APE10-dist-in 5.606 APE9-dist-in 3.784 None None None XRAY 2.2 0.167 0.196 B 298 270 0 0 0 0 [[38, 290]] 1.0 5vua CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5VUBB P11309 36 305 313.0 8GU:402 Type1 Active DFGin 6.265 14.605 BLAminus DFGAsp-rot-in -124.74, 173.14 60.11, 84.16 193.47, 8.44 -95.33, 18.9 286.57, 72.73 -67.18, -11.28 in-in in 8.585 Saltbr-in 2.363 HRD-na-A -74.43, -46.89 71.06, 5.3 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.25, 31.18 APE9-dihe-na -85.43, -151.45 APE8-dihe-in -96.33, 120.96 APE8-rot-in 305.35 APE67-dihe-in -68.9, -7.9 -56.39, -44.27 APE12-dist-in 9.371 APE11-dist-in 8.569 APE10-dist-in 5.573 APE9-dist-in 3.652 None None CSO161 XRAY 2.0 0.161 0.184 B 298 270 0 0 0 0 [[38, 290]] 1.0 5vub CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5VUCB P11309 36 305 313.0 8GR:402 Type1 Active DFGin 6.26 14.59 BLAminus DFGAsp-rot-in -130.18, 165.22 63.78, 87.26 188.35, 8.52 -96.8, 21.67 286.89, 72.33 -70.38, -11.1 in-in in 8.271 Saltbr-in 2.78 HRD-na-A -75.49, -49.39 71.96, 7.41 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.01, 27.32 APE9-dihe-na -81.89, -157.57 APE8-dihe-in -92.9, 123.77 APE8-rot-in 305.96 APE67-dihe-in -68.92, -9.19 -62.84, -43.07 APE12-dist-in 9.193 APE11-dist-in 8.559 APE10-dist-in 5.434 APE9-dist-in 3.767 None None CSO161 XRAY 2.0 0.176 0.199 B 298 270 0 0 0 0 [[38, 290]] 1.0 5vuc CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3R00A P11309 33 306 313.0 UNJ:1 Type1 Active DFGin 6.077 14.585 BLAminus DFGAsp-rot-in -129.23, 179.95 62.78, 78.65 200.04, -3.67 -92.67, 17.69 284.89, 76.92 -65.27, -12.58 in-in in 8.985 Saltbr-in 2.615 HRD-na-A -69.03, -46.16 61.18, 15.3 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.83, 36.17 APE9-dihe-na -94.5, -143.14 APE8-dihe-in -99.32, 120.22 APE8-rot-in 298.64 APE67-dihe-in -66.4, -11.74 -58.9, -42.32 APE12-dist-in 9.811 APE11-dist-in 8.531 APE10-dist-in 5.639 APE9-dist-in 3.719 None None None XRAY 2.1 0.175 0.216 A 299 274 0 0 0 0 [[38, 290]] 1.0 3r00 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3R01A P11309 33 306 313.0 UNE:1 Type1 Active DFGin 6.171 14.639 BLAminus DFGAsp-rot-in -135.6, 167.7 70.77, 75.77 195.07, -4.97 -84.82, 17.16 285.86, 84.24 -68.67, -10.33 in-in in 8.803 Saltbr-in 2.883 HRD-na-A -70.35, -49.23 74.71, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.59, 35.76 APE9-dihe-na -87.25, -132.26 APE8-dihe-in -117.56, 118.78 APE8-rot-in 316.73 APE67-dihe-in -73.58, -11.68 -54.47, -42.96 APE12-dist-in 9.738 APE11-dist-in 8.508 APE10-dist-in 5.818 APE9-dist-in 3.924 None None None XRAY 2.6 0.219 0.287 A 299 274 0 0 0 0 [[38, 290]] 1.0 3r01 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3R02A P11309 35 305 313.0 UNM:555 Type1 Active DFGin 6.175 14.566 BLAminus DFGAsp-rot-in -128.64, 175.57 56.97, 87.35 193.18, 12.87 -90.49, 17.56 285.73, 81.34 -74.51, -7.05 in-in in 9.028 Saltbr-in 2.634 HRD-na-A -75.58, -44.47 72.61, 3.3 in-in-in SNCiii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.47, 29.58 APE9-dihe-na -87.11, -147.11 APE8-dihe-in -98.53, 121.85 APE8-rot-in 301.03 APE67-dihe-in -70.13, -7.69 -53.51, -42.81 APE12-dist-in 9.845 APE11-dist-in 8.584 APE10-dist-in 5.794 APE9-dist-in 3.758 None None None XRAY 1.95 0.168 0.189 A 299 271 0 0 0 0 [[38, 290]] 1.0 3r02 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3R04A P11309 35 305 313.0 UNQ:555 Type1 Active DFGin 6.111 14.493 BLAminus DFGAsp-rot-in -119.88, 174.34 65.61, 74.31 199.3, -5.77 -82.3, 14.36 287.66, 74.37 -62.06, -16.62 in-in in 8.928 Saltbr-in 2.634 HRD-na-A -74.82, -45.09 62.9, 11.66 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.54, 31.05 APE9-dihe-na -88.35, -143.56 APE8-dihe-in -101.19, 121.66 APE8-rot-in 294.82 APE67-dihe-in -73.54, -5.15 -62.57, -37.68 APE12-dist-in 9.848 APE11-dist-in 8.502 APE10-dist-in 5.644 APE9-dist-in 3.722 None None None XRAY 1.7 0.179 0.206 A 299 271 0 0 0 0 [[38, 290]] 1.0 3r04 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3VBQA P11309 35 305 313.0 0F5:555 Type1 Active DFGin 6.198 14.577 BLAminus DFGAsp-rot-in -127.7, 179.22 57.68, 76.69 200.1, -0.63 -85.86, 12.59 286.24, 73.15 -68.96, -5.86 in-in in 8.768 Saltbr-in 2.64 HRD-na-A -70.31, -44.96 66.03, 8.09 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.65, 27.89 APE9-dihe-na -90.08, -142.39 APE8-dihe-in -98.6, 121.83 APE8-rot-in 304.23 APE67-dihe-in -72.3, -7.09 -58.75, -37.63 APE12-dist-in 9.812 APE11-dist-in 8.595 APE10-dist-in 5.699 APE9-dist-in 3.703 None None None XRAY 1.85 0.206 0.206 A 299 271 0 0 0 0 [[38, 290]] 1.0 3vbq CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3VBVA P11309 35 305 313.0 0FK:1 Type1 Active DFGin 6.168 14.524 BLAminus DFGAsp-rot-in -132.06, 170.0 63.81, 81.21 201.12, 0.72 -91.04, 16.51 285.74, 75.33 -71.88, -8.41 in-in in 8.834 Saltbr-in 2.633 HRD-na-A -65.91, -47.52 66.96, 5.14 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.35, 27.86 APE9-dihe-na -84.91, -139.46 APE8-dihe-in -108.06, 126.97 APE8-rot-in 303.82 APE67-dihe-in -70.7, -8.74 -60.57, -44.13 APE12-dist-in 9.499 APE11-dist-in 8.439 APE10-dist-in 5.663 APE9-dist-in 3.672 None None None XRAY 2.08 0.245 0.245 A 299 268 3 0 0 0 [[38, 290]] 1.0 3vbv CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3VBWA P11309 35 305 313.0 0FN:1 Type1 Active DFGin 6.059 14.28 BLAminus DFGAsp-rot-in -127.49, 167.57 67.98, 79.4 206.91, -5.37 -86.02, 16.62 293.39, 81.3 -60.91, -19.46 in-in in 8.861 Saltbr-in 2.879 HRD-na-A -70.94, -49.39 81.06, -4.45 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.47, 33.12 APE9-dihe-na -84.03, -133.93 APE8-dihe-in -105.55, 127.02 APE8-rot-in 315.81 APE67-dihe-in -63.23, -11.02 -61.62, -47.09 APE12-dist-in 9.541 APE11-dist-in 8.343 APE10-dist-in 5.672 APE9-dist-in 3.85 None None None XRAY 2.48 0.299 0.299 A 299 264 7 0 0 0 [[38, 290]] 1.0 3vbw CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3VBYA P11309 35 305 313.0 0FR:1 Type1 Active DFGin 6.143 14.631 BLAminus DFGAsp-rot-in -131.01, 169.0 66.5, 79.73 195.62, 2.78 -89.48, 18.31 287.57, 72.75 -74.21, -13.52 in-in in 8.952 Saltbr-in 2.761 HRD-na-A -68.42, -44.76 63.69, 3.49 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.13, 34.14 APE9-dihe-na -92.9, -153.09 APE8-dihe-in -93.99, 123.58 APE8-rot-in 305.15 APE67-dihe-in -72.64, -2.35 -57.97, -45.41 APE12-dist-in 9.328 APE11-dist-in 8.347 APE10-dist-in 5.512 APE9-dist-in 3.825 None None None XRAY 2.27 0.261 0.261 A 299 267 4 0 0 0 [[38, 290]] 1.0 3vby CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3VC4A P11309 33 306 313.0 0FS:1 Type1 Active DFGin 6.076 14.609 BLAminus DFGAsp-rot-in -139.74, 164.89 72.09, 84.05 197.34, -4.54 -96.17, 20.14 288.43, 67.45 -72.44, -2.97 in-in in 9.03 Saltbr-in 2.661 HRD-na-A -61.2, -51.03 71.16, 7.63 in-in-in SNCiii in-in ActLoopNT-in 2.724 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.23, 31.29 APE9-dihe-na -95.97, -149.39 APE8-dihe-in -93.38, 121.01 APE8-rot-in 311.86 APE67-dihe-in -66.44, -6.52 -55.27, -50.39 APE12-dist-in 9.953 APE11-dist-in 8.561 APE10-dist-in 5.461 APE9-dist-in 3.801 None None None XRAY 2.23 0.319 0.319 A 299 274 0 0 0 0 [[38, 290]] 1.0 3vc4 CAMK_PIM1_HUMAN CAMK 3.5e-65 225.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3F2AA P11309 32 308 313.0 985:1 Type1 Active DFGin 6.088 14.312 BLAminus DFGAsp-rot-in -128.57, 176.64 59.08, 83.27 202.16, -10.61 -93.92, 21.71 288.01, 71.24 -68.66, -6.64 in-in in 8.744 Saltbr-in 2.789 HRD-na-A -68.81, -50.19 71.47, 2.55 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.81, 27.99 APE9-dihe-na -90.31, -146.93 APE8-dihe-in -92.75, 125.96 APE8-rot-in 310.85 APE67-dihe-in -59.77, -4.55 -52.49, -57.5 APE12-dist-in 9.882 APE11-dist-in 8.774 APE10-dist-in 5.552 APE9-dist-in 3.643 None SEP261 SEP261 XRAY 1.9 0.256 0.282 A 300 277 0 0 0 0 [[38, 290]] 1.0 3f2a CAMK_PIM1_HUMAN CAMK 3.5e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2XIXA P11309 33 306 313.0 XIX:1307 Type1 Active DFGin 6.198 14.405 BLAminus DFGAsp-rot-in -127.72, 172.47 53.38, 85.02 189.63, 17.67 -93.57, 22.7 288.78, 75.96 -73.48, -9.49 in-in in 8.795 Saltbr-in 2.619 HRD-na-A -70.78, -45.87 74.83, 0.99 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.52, 26.26 APE9-dihe-na -83.36, -151.06 APE8-dihe-in -94.01, 119.49 APE8-rot-in 303.81 APE67-dihe-in -72.45, -16.36 -55.92, -38.22 APE12-dist-in 9.715 APE11-dist-in 8.635 APE10-dist-in 5.698 APE9-dist-in 3.668 None SEP261,SEP276 SEP261,SEP276 XRAY 2.4 0.173 0.214 A 301 274 0 0 0 0 [[38, 290]] 1.0 2xix CAMK_PIM1_HUMAN CAMK 3.6e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2XIZA P11309 33 306 313.0 XIZ:1307 Type1 Active DFGin 6.176 14.549 BLAminus DFGAsp-rot-in -122.54, 175.77 58.35, 84.58 194.58, -2.35 -93.18, 17.46 282.52, 76.08 -67.84, -13.59 in-in in 8.866 Saltbr-in 2.579 HRD-na-A -67.92, -44.32 48.8, 19.99 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.12, 25.76 APE9-dihe-na -79.92, -145.43 APE8-dihe-in -101.02, 126.08 APE8-rot-in 309.36 APE67-dihe-in -71.71, -14.75 -59.22, -39.66 APE12-dist-in 9.753 APE11-dist-in 8.684 APE10-dist-in 5.651 APE9-dist-in 3.684 None SEP261 SEP261 XRAY 2.21 0.258 0.286 A 301 274 0 0 0 0 [[38, 290]] 1.0 2xiz CAMK_PIM1_HUMAN CAMK 3.6e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2XJ0A P11309 33 307 313.0 XJ0:1307 Type1 Active DFGin 5.929 13.676 BLAminus DFGAsp-rot-in -134.6, 165.43 58.42, 101.5 176.94, 52.12 -112.27, 25.85 290.56, 60.01 -70.79, -14.26 in-in in 8.68 Saltbr-in 2.966 HRD-na-A -62.77, -42.06 61.42, 5.55 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.92, 10.17 APE9-dihe-na -82.33, -169.45 APE8-dihe-in -68.0, 130.83 APE8-rot-in 305.92 APE67-dihe-in -52.49, -21.01 -63.78, -52.51 APE12-dist-in 9.771 APE11-dist-in 8.468 APE10-dist-in 4.976 APE9-dist-in 3.897 None None None XRAY 3.1 0.218 0.263 A 301 275 0 0 0 0 [[38, 290]] 1.0 2xj0 CAMK_PIM1_HUMAN CAMK 3.6e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2XJ1A P11309 33 306 313.0 XJ1:1307 Type1 Active DFGin 6.25 14.296 BLAminus DFGAsp-rot-in -129.27, 177.63 56.13, 82.39 198.57, 3.86 -92.13, 21.02 283.59, 76.59 -73.33, -11.63 in-in in 8.873 Saltbr-in 2.708 HRD-na-A -72.25, -47.05 68.39, 1.49 in-in-in SNCiii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.13, 25.06 APE9-dihe-na -81.21, -153.15 APE8-dihe-in -95.3, 123.79 APE8-rot-in 303.34 APE67-dihe-in -71.81, -9.27 -59.4, -42.14 APE12-dist-in 9.877 APE11-dist-in 8.571 APE10-dist-in 5.6 APE9-dist-in 3.61 None SEP261 SEP261 XRAY 2.13 0.178 0.212 A 301 274 0 0 0 0 [[38, 290]] 1.0 2xj1 CAMK_PIM1_HUMAN CAMK 3.6e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2XJ2A P11309 33 306 313.0 985:1001 Type1 Active DFGin 6.157 14.389 BLAminus DFGAsp-rot-in -121.97, 176.14 56.84, 82.15 195.16, 11.52 -90.5, 18.96 286.44, 74.76 -71.88, -10.32 in-in in 8.809 Saltbr-in 2.645 HRD-na-A -70.41, -47.45 68.26, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.43, 24.44 APE9-dihe-na -81.03, -149.66 APE8-dihe-in -95.09, 121.86 APE8-rot-in 305.59 APE67-dihe-in -74.97, -11.2 -56.65, -40.34 APE12-dist-in 9.835 APE11-dist-in 8.669 APE10-dist-in 5.671 APE9-dist-in 3.522 None SEP261 SEP261 XRAY 2.2 0.169 0.202 A 301 274 0 0 0 0 [[38, 290]] 1.0 2xj2 CAMK_PIM1_HUMAN CAMK 3.6e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4A7CA P11309 32 305 313.0 E46:1306 Type1 Active DFGin 6.179 14.789 BLAminus DFGAsp-rot-in -131.67, 167.73 66.77, 79.73 196.32, -1.56 -90.97, 18.69 290.12, 73.93 -69.69, -11.45 in-in in 8.903 Saltbr-in 2.55 HRD-na-A -69.9, -49.4 70.62, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.768 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.97, 35.42 APE9-dihe-na -90.39, -152.55 APE8-dihe-in -91.86, 121.24 APE8-rot-in 305.64 APE67-dihe-in -69.15, -9.02 -58.09, -44.18 APE12-dist-in 9.561 APE11-dist-in 8.624 APE10-dist-in 5.657 APE9-dist-in 3.877 None SEP261 SEP261 XRAY 2.3 0.171 0.207 A 308 274 0 0 0 0 [[38, 290]] 1.0 4a7c CAMK_PIM1_HUMAN CAMK 3.9e-65 225.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XWSA P11309 33 305 313.0 BI1:1001 Type1 Active DFGin 6.116 14.934 BLAminus DFGAsp-rot-in -129.52, 166.95 66.18, 81.14 195.1, -6.35 -88.91, 13.45 284.44, 80.6 -63.86, -15.19 in-in in 8.858 Saltbr-in 2.811 HRD-na-A -69.66, -47.71 69.42, 1.43 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.43, 26.37 APE9-dihe-na -77.62, -162.66 APE8-dihe-in -79.83, 125.2 APE8-rot-in 307.07 APE67-dihe-in -74.93, -11.45 -55.08, -43.34 APE12-dist-in 9.706 APE11-dist-in 8.766 APE10-dist-in 5.868 APE9-dist-in 3.845 None None None XRAY 1.8 0.182 0.213 A 313 273 0 0 0 0 [[38, 290]] 1.0 1xws CAMK_PIM1_HUMAN CAMK 4.1e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 9YKIA P11309 33 306 313.0 A1CXP:401 Type1 Active DFGin 6.21 14.383 BLAminus DFGAsp-rot-in -125.706, 175.8205 59.5591, 74.2517 194.5739, 4.7062 -86.4556, 14.0294 279.7187, 78.161 -81.0045, -0.7202 in-in in 8.775 Saltbr-in 2.567 HRD-na-A -75.6042, -43.0685 69.3841, 4.7598 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.3548, 34.3232 APE9-dihe-na -87.2021, -145.6999 APE8-dihe-in -99.5491, 121.5864 APE8-rot-in 305.2394 APE67-dihe-in -69.9218, -9.3957 -57.3812, -45.5422 APE12-dist-in 9.574 APE11-dist-in 8.811 APE10-dist-in 5.632 APE9-dist-in 3.739 None SEP261 SEP261 XRAY 1.95 0.163 0.193 A 313 274 0 0 0 0 [[38, 290]] 1.0 9yki CAMK_PIM1_HUMAN CAMK 4.1e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4BZNA P11309 33 305 313.0 UGX:1306 Type1 Active DFGin 6.199 14.508 BLAminus DFGAsp-rot-in -123.83, 168.52 64.99, 88.0 202.18, -19.04 -96.39, 24.65 289.87, 72.27 -71.02, -12.29 in-in in 8.396 Saltbr-in 2.579 HRD-na-A -70.91, -47.25 68.09, 6.65 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 29.38 APE9-dihe-na -84.39, -152.15 APE8-dihe-in -95.81, 123.59 APE8-rot-in 305.15 APE67-dihe-in -71.92, -8.16 -59.74, -41.18 APE12-dist-in 9.359 APE11-dist-in 8.444 APE10-dist-in 5.519 APE9-dist-in 3.61 None SEP261 SEP261 XRAY 1.9 0.178 0.199 A 314 273 0 0 0 0 [[38, 290]] 1.0 4bzn CAMK_PIM1_HUMAN CAMK 4.2e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4BZOA P11309 33 305 313.0 676:1306 Type1 Active DFGin 6.254 14.762 BLAminus DFGAsp-rot-in -127.92, 165.55 68.25, 84.97 200.81, -11.32 -95.87, 20.96 286.29, 72.86 -74.22, -6.71 in-in in 8.44 Saltbr-in 2.622 HRD-na-A -71.06, -49.33 68.13, 9.04 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.68, 32.17 APE9-dihe-na -87.85, -152.26 APE8-dihe-in -92.39, 123.96 APE8-rot-in 304.04 APE67-dihe-in -67.43, -9.74 -60.54, -43.52 APE12-dist-in 9.601 APE11-dist-in 8.585 APE10-dist-in 5.536 APE9-dist-in 3.662 None SEP261 SEP261 XRAY 2.1 0.183 0.216 A 314 273 0 0 0 0 [[38, 290]] 1.0 4bzo CAMK_PIM1_HUMAN CAMK 4.2e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7ZUNA P11309 33 305 313.0 JYO:401 Type1 Active DFGin 6.22 14.208 BLAminus DFGAsp-rot-in -133.16, 165.47 67.55, 84.83 196.38, -5.08 -98.38, 21.66 289.12, 75.62 -70.0, -22.74 in-in in 8.206 Saltbr-in 2.792 HRD-na-A -67.79, -58.14 75.87, 8.23 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.98, 24.87 APE9-dihe-na -93.48, -164.33 APE8-dihe-in -86.18, 121.45 APE8-rot-in 312.27 APE67-dihe-in -61.31, -13.56 -57.48, -51.41 APE12-dist-in 9.43 APE11-dist-in 8.444 APE10-dist-in 5.049 APE9-dist-in 3.873 None SEP261 SEP261 XRAY 2.5 0.177 0.235 A 314 270 3 0 0 0 [[38, 290]] 1.0 7zun CAMK_PIM1_HUMAN CAMK 4.2e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4XHKB P11309 32 305 313.0 3YR:401 Type1 Active DFGin 6.226 14.525 BLAminus DFGAsp-rot-in -126.44, 167.48 62.73, 73.24 195.77, 4.57 -76.02, 8.65 289.12, 83.25 -72.3, -9.91 in-in in 8.861 Saltbr-in 2.614 HRD-na-A -68.85, -46.46 65.48, 11.28 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.53, 24.82 APE9-dihe-na -81.56, -148.04 APE8-dihe-in -105.73, 126.46 APE8-rot-in 298.97 APE67-dihe-in -77.31, -6.66 -69.47, -34.63 APE12-dist-in 9.573 APE11-dist-in 8.684 APE10-dist-in 5.642 APE9-dist-in 3.72 None SEP261 SEP261 XRAY 1.9 0.158 0.184 B 315 270 4 0 0 0 [[38, 290]] 1.0 4xhk CAMK_PIM1_HUMAN CAMK 4.2e-65 225.6 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4JX7A P11309 33 306 313.0 1N6:401 Type1 Active DFGin 6.284 14.753 BLAminus DFGAsp-rot-in -127.31, 170.34 63.68, 81.99 193.64, 4.9 -92.92, 12.24 283.66, 75.72 -67.48, -14.52 in-in in 8.843 Saltbr-in 2.768 HRD-na-A -66.3, -47.17 67.1, 1.58 in-in-in SNCiii in-in ActLoopNT-in 2.734 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.4, 25.92 APE9-dihe-na -85.09, -149.75 APE8-dihe-in -93.53, 123.68 APE8-rot-in 312.23 APE67-dihe-in -66.8, -17.18 -56.19, -45.11 APE12-dist-in 9.756 APE11-dist-in 8.59 APE10-dist-in 5.605 APE9-dist-in 3.904 None None None XRAY 2.4 0.193 0.228 A 326 274 0 0 0 0 [[38, 290]] 1.0 4jx7 CAMK_PIM1_HUMAN CAMK 4.7e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4ALVA P11309 33 306 313.0 R9P:1308 Type1 Active DFGin 6.036 14.476 BLAminus DFGAsp-rot-in -137.53, 165.69 68.25, 83.91 196.24, 5.5 -91.38, 16.23 287.59, 75.48 -60.65, -18.54 in-in in 8.663 Saltbr-in 2.34 HRD-na-A -75.94, -45.06 66.41, 17.82 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.01, 38.02 APE9-dihe-na -89.15, -139.06 APE8-dihe-in -112.86, 124.4 APE8-rot-in 319.08 APE67-dihe-in -51.23, -17.72 -57.73, -58.1 APE12-dist-in 9.415 APE11-dist-in 8.687 APE10-dist-in 5.707 APE9-dist-in 3.686 None None None XRAY 2.59 0.195 0.256 A 328 274 0 0 0 0 [[38, 290]] 1.0 4alv CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4ALWA P11309 34 306 313.0 HY7:1308 Type1 Active DFGin 6.005 14.595 BLAminus DFGAsp-rot-in -122.86, 171.92 71.12, 81.46 182.74, 20.58 -94.23, 18.88 291.83, 80.43 -59.13, -19.56 in-in in 8.861 Saltbr-in 2.609 HRD-na-A -72.84, -43.49 62.9, 3.06 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.98, 32.2 APE9-dihe-na -91.86, -145.44 APE8-dihe-in -92.13, 124.7 APE8-rot-in 302.73 APE67-dihe-in -76.25, -2.93 -59.68, -41.94 APE12-dist-in 9.632 APE11-dist-in 8.509 APE10-dist-in 5.744 APE9-dist-in 3.771 None None None XRAY 1.92 0.158 0.207 A 328 273 0 0 0 0 [[38, 290]] 1.0 4alw CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4N6YA P11309 32 305 313.0 2HV:401 Type1 Active DFGin 6.259 14.881 BLAminus DFGAsp-rot-in -123.98, 165.51 60.84, 90.41 190.49, 15.31 -100.85, 18.31 286.86, 79.6 -74.61, -13.5 in-in in 8.761 Saltbr-in 2.709 HRD-na-A -69.76, -50.01 73.25, 2.39 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.48, 35.75 APE9-dihe-na -98.87, -155.99 APE8-dihe-in -86.09, 125.72 APE8-rot-in 310.58 APE67-dihe-in -66.86, -9.74 -54.28, -49.47 APE12-dist-in 9.387 APE11-dist-in 8.441 APE10-dist-in 5.401 APE9-dist-in 3.77 None SEP261 SEP261 XRAY 2.6 0.159 0.212 A 328 274 0 0 0 0 [[38, 290]] 1.0 4n6y CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4N6ZA P11309 33 305 313.0 2HW:401 Type1 Active DFGin 6.463 14.646 BLAminus DFGAsp-rot-in -126.99, 169.95 59.29, 83.89 191.21, 15.21 -97.92, 18.69 285.67, 67.47 -72.35, -9.24 in-in in 8.254 Saltbr-in 2.729 HRD-na-A -69.23, -47.57 69.1, 0.1 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.18, 25.75 APE9-dihe-na -86.3, -154.15 APE8-dihe-in -92.66, 118.79 APE8-rot-in 308.24 APE67-dihe-in -66.17, -14.41 -51.57, -45.87 APE12-dist-in 9.465 APE11-dist-in 8.513 APE10-dist-in 5.379 APE9-dist-in 3.694 None SEP261 SEP261 XRAY 2.2 0.161 0.189 A 328 273 0 0 0 0 [[38, 290]] 1.0 4n6z CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4N70A P11309 32 306 313.0 2HX:401 Type1 Active DFGin 6.165 14.569 BLAminus DFGAsp-rot-in -137.89, 169.53 64.36, 80.83 189.6, 9.98 -93.88, 21.26 288.11, 67.53 -75.41, -5.31 in-in in 8.624 Saltbr-in 2.6 HRD-na-A -69.13, -48.86 67.14, 6.63 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.37, 33.23 APE9-dihe-na -89.84, -146.82 APE8-dihe-in -98.54, 120.46 APE8-rot-in 304.86 APE67-dihe-in -67.47, -8.0 -60.04, -43.4 APE12-dist-in 9.594 APE11-dist-in 8.659 APE10-dist-in 5.723 APE9-dist-in 3.757 None SEP261 SEP261 XRAY 2.1 0.169 0.208 A 328 275 0 0 0 0 [[38, 290]] 1.0 4n70 CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5DWRA P11309 33 306 313.0 5H7:401 Type1 Active DFGin 6.242 14.664 BLAminus DFGAsp-rot-in -131.54, 168.2 64.5, 84.97 186.53, 15.24 -98.37, 18.01 285.62, 75.32 -66.32, -15.3 in-in in 8.548 Saltbr-in 2.67 HRD-na-A -72.01, -47.63 67.32, 6.26 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, 26.57 APE9-dihe-na -84.89, -152.84 APE8-dihe-in -93.58, 121.01 APE8-rot-in 307.85 APE67-dihe-in -68.04, -7.01 -54.84, -45.5 APE12-dist-in 9.522 APE11-dist-in 8.531 APE10-dist-in 5.418 APE9-dist-in 3.651 None SEP261 SEP261 XRAY 2.0 0.175 0.202 A 328 274 0 0 0 0 [[38, 290]] 1.0 5dwr CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6YKDA P11309 33 305 313.0 OWB:60400 Type1 Active DFGin 6.158 14.69 BLAminus DFGAsp-rot-in -121.19, 171.99 65.51, 79.7 193.03, 6.79 -90.44, 14.31 281.37, 83.04 -61.46, -20.23 in-in in 8.931 Saltbr-in 2.681 HRD-na-A -69.86, -48.77 63.9, 14.36 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.12, 24.2 APE9-dihe-na -86.9, -151.63 APE8-dihe-in -93.7, 123.39 APE8-rot-in 303.13 APE67-dihe-in -72.97, -5.5 -60.57, -42.11 APE12-dist-in 9.604 APE11-dist-in 8.528 APE10-dist-in 5.414 APE9-dist-in 3.739 None SEP261 SEP261 XRAY 1.86 0.16 0.194 A 329 273 0 0 0 0 [[38, 290]] 1.0 6ykd CAMK_PIM1_HUMAN CAMK 4.9e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2OBJA P11309 33 305 313.0 VRV:400 Type1 Active DFGin 5.848 14.342 BLAminus DFGAsp-rot-in -135.1, 165.89 65.58, 81.59 188.2, 26.71 -93.29, 20.74 291.15, 68.53 -60.11, -19.32 in-in in 8.684 Saltbr-in 2.448 HRD-na-A -67.98, -46.96 66.7, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.26, 30.91 APE9-dihe-na -92.97, -164.42 APE8-dihe-in -76.75, 121.77 APE8-rot-in 305.59 APE67-dihe-in -61.67, -9.38 -55.68, -49.65 APE12-dist-in 9.445 APE11-dist-in 8.506 APE10-dist-in 5.338 APE9-dist-in 3.754 None SEP261 SEP261 XRAY 2.5 0.205 0.246 A 333 273 0 0 0 0 [[38, 290]] 1.0 2obj CAMK_PIM1_HUMAN CAMK 5.1e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3BGPA P11309 33 305 313.0 VX1:314 Type1 Active DFGin 5.943 14.425 BLAminus DFGAsp-rot-in -126.41, 157.1 77.54, 91.73 193.15, 9.64 -104.16, 28.82 293.34, 70.26 -65.15, -26.7 in-in in 8.631 Saltbr-in 2.629 HRD-na-A -72.43, -49.43 73.8, -3.17 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.31, 13.68 APE9-dihe-na -86.06, -170.88 APE8-dihe-in -67.89, 136.06 APE8-rot-in 304.87 APE67-dihe-in -64.78, -12.46 -73.3, -44.0 APE12-dist-in 9.366 APE11-dist-in 8.562 APE10-dist-in 4.982 APE9-dist-in 3.928 None SEP261 SEP261 XRAY 2.8 0.213 0.261 A 333 273 0 0 0 0 [[38, 290]] 1.0 3bgp CAMK_PIM1_HUMAN CAMK 5.1e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3BGQA P11309 33 305 313.0 VX2:314 Type1 Active DFGin 6.395 14.856 BLAminus DFGAsp-rot-in -129.22, 172.22 56.92, 80.34 189.72, 13.58 -93.96, 24.94 287.45, 64.49 -68.32, -10.99 in-in in 8.427 Saltbr-in 2.659 HRD-na-A -70.11, -48.13 67.03, 6.04 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.69, 26.46 APE9-dihe-na -85.59, -155.16 APE8-dihe-in -92.08, 118.01 APE8-rot-in 308.33 APE67-dihe-in -63.18, -11.49 -49.18, -49.37 APE12-dist-in 9.607 APE11-dist-in 8.586 APE10-dist-in 5.411 APE9-dist-in 3.639 None SEP261 SEP261 XRAY 2.0 0.213 0.23 A 333 273 0 0 0 0 [[38, 290]] 1.0 3bgq CAMK_PIM1_HUMAN CAMK 5.1e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3BGZA P11309 33 305 313.0 VX3:314 Type1 Active DFGin 6.223 14.508 BLAminus DFGAsp-rot-in -126.99, 169.09 64.54, 79.92 191.21, 21.9 -92.02, 15.99 284.89, 75.21 -68.7, -13.09 in-in in 8.734 Saltbr-in 2.726 HRD-na-A -68.01, -47.53 72.06, 3.12 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.26, 35.08 APE9-dihe-na -86.26, -142.72 APE8-dihe-in -103.04, 122.93 APE8-rot-in 309.34 APE67-dihe-in -67.64, -10.68 -55.55, -46.74 APE12-dist-in 9.534 APE11-dist-in 8.646 APE10-dist-in 5.671 APE9-dist-in 3.689 None SEP261 SEP261 XRAY 2.4 0.196 0.233 A 333 268 5 0 0 0 [[38, 290]] 1.0 3bgz CAMK_PIM1_HUMAN CAMK 5.1e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4AS0A P11309 33 305 313.0 RPS:1306 Type1 Active DFGin 6.239 14.797 BLAminus DFGAsp-rot-in -125.08, 170.08 63.9, 84.56 194.91, 12.14 -93.79, 23.62 287.71, 77.4 -74.79, -13.31 in-in in 8.997 Saltbr-in 2.486 HRD-na-A -73.68, -44.47 70.76, -1.79 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.05, 33.62 APE9-dihe-na -96.04, -155.25 APE8-dihe-in -91.93, 124.92 APE8-rot-in 312.41 APE67-dihe-in -67.91, -14.18 -64.04, -41.51 APE12-dist-in 9.586 APE11-dist-in 8.521 APE10-dist-in 5.397 APE9-dist-in 4.179 None None None XRAY 2.3 0.172 0.201 A 273 273 0 0 0 0 [[38, 290]] 1.0 4as0 CAMK_PIM1_HUMAN CAMK 9.5e-65 224.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5TURA P11309 34 306 313.0 7LK:401 Type1 Active DFGin 6.061 14.49 BLAminus DFGAsp-rot-in -136.79, 174.59 58.79, 85.71 191.92, 46.05 -98.08, 24.51 288.61, 83.41 -77.7, -2.74 in-in in 8.758 Saltbr-in 2.616 HRD-na-A -76.1, -44.31 69.09, 5.73 in-in-in SNCiii in-in ActLoopNT-in 2.743 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.99, 42.91 APE9-dihe-na -110.95, -154.07 APE8-dihe-in -91.19, 125.87 APE8-rot-in 304.26 APE67-dihe-in -69.95, -16.95 -69.94, -33.83 APE12-dist-in 9.736 APE11-dist-in 8.798 APE10-dist-in 5.354 APE9-dist-in 3.965 None None None XRAY 2.948 0.209 0.248 A 404 270 3 0 0 0 [[38, 290]] 1.0 5tur CAMK_PIM1_HUMAN CAMK 9.2e-65 224.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2J2IB P11309 33 305 313.0 LY4:1307 Type1 Active DFGin 6.349 14.788 BLAminus DFGAsp-rot-in -124.69, 164.2 69.56, 81.11 195.22, -4.17 -88.57, 16.71 287.44, 78.04 -63.89, -22.24 in-in in 8.715 Saltbr-in 2.884 HRD-na-A -68.27, -48.73 73.43, 1.94 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.68, 17.7 APE9-dihe-na -79.18, -163.88 APE8-dihe-in -85.23, 122.14 APE8-rot-in 304.09 APE67-dihe-in -70.03, -11.09 -55.65, -47.61 APE12-dist-in 9.314 APE11-dist-in 8.701 APE10-dist-in 5.457 APE9-dist-in 3.964 R250G None None XRAY 1.9 0.18 0.2 B 312 273 0 0 0 0 [[38, 290]] 1.0 2j2i CAMK_PIM1_HUMAN CAMK 1.5e-64 223.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7QB2A P11309 33 305 313.0 A7X:402 Type1 Active DFGin 6.261 14.434 BLAminus DFGAsp-rot-in -125.87, 176.63 53.43, 82.5 191.32, 4.61 -86.6, 20.72 284.17, 73.36 -70.8, -10.08 in-in in 8.657 Saltbr-in 2.608 HRD-na-A -76.36, -48.43 70.95, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.692 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.34, 22.15 APE9-dihe-na -86.92, -149.81 APE8-dihe-in -97.03, 122.97 APE8-rot-in 300.26 APE67-dihe-in -69.31, -7.68 -64.45, -41.13 APE12-dist-in 9.926 APE11-dist-in 8.652 APE10-dist-in 4.975 APE9-dist-in 3.744 R250G SEP261 SEP261 XRAY 2.53 0.159 0.202 A 312 273 0 0 0 0 [[38, 290]] 1.0 7qb2 CAMK_PIM1_HUMAN CAMK 1.5e-64 223.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7QFMA P11309 33 305 313.0 AY3:402 Type1 Active DFGin 6.203 14.458 BLAminus DFGAsp-rot-in -124.14, 177.11 57.14, 79.43 193.69, -3.72 -85.98, 19.87 284.85, 75.66 -69.01, -15.13 in-in in 8.765 Saltbr-in 2.692 HRD-na-A -73.09, -45.9 66.81, 9.42 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.28, 26.43 APE9-dihe-na -81.47, -151.25 APE8-dihe-in -97.97, 122.34 APE8-rot-in 302.11 APE67-dihe-in -71.87, -9.27 -61.74, -39.67 APE12-dist-in 9.911 APE11-dist-in 8.61 APE10-dist-in 5.375 APE9-dist-in 3.614 R250G SEP261 SEP261 XRAY 1.95 0.159 0.178 A 312 271 2 0 0 0 [[38, 290]] 1.0 7qfm CAMK_PIM1_HUMAN CAMK 1.5e-64 223.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3JPVA P11309 33 305 313.0 1DR:313 Type1 Active DFGin 6.148 14.441 BLAminus DFGAsp-rot-in -120.08, 164.67 68.13, 86.84 196.87, -3.9 -92.5, 13.59 289.99, 74.69 -67.43, -13.65 in-in in 9.003 Saltbr-in 2.563 HRD-na-A -72.55, -46.96 72.58, 4.93 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.51, 21.98 APE9-dihe-na -83.62, -150.17 APE8-dihe-in -98.9, 116.73 APE8-rot-in 306.83 APE67-dihe-in -67.26, -10.5 -54.29, -42.64 APE12-dist-in 9.823 APE11-dist-in 8.439 APE10-dist-in 5.413 APE9-dist-in 3.764 None None None XRAY 2.35 0.176 0.226 A 313 273 0 0 0 0 [[38, 290]] 1.0 3jpv CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3MA3A P11309 37 305 313.0 01I:313 Type1 Active DFGin 6.018 14.237 BLAminus DFGAsp-rot-in -126.51, 170.48 60.71, 85.71 191.56, 6.59 -91.62, 21.05 288.87, 82.52 -71.65, -14.95 in-in in 8.917 Saltbr-in 2.691 HRD-na-A -71.5, -42.79 64.42, 10.83 in-in-in SNCiii in-in ActLoopNT-in 2.754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 17.84 APE9-dihe-na -81.84, -163.49 APE8-dihe-in -85.13, 123.05 APE8-rot-in 304.03 APE67-dihe-in -65.07, -11.91 -66.26, -41.53 APE12-dist-in 9.812 APE11-dist-in 8.402 APE10-dist-in 5.221 APE9-dist-in 3.879 None SEP261 SEP261 XRAY 2.3 0.172 0.233 A 313 267 2 0 0 0 [[38, 290]] 1.0 3ma3 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3QF9A P11309 32 305 313.0 NM8:313 Type1 Active DFGin 6.07 14.424 BLAminus DFGAsp-rot-in -120.87, 169.05 67.22, 78.8 196.23, -1.72 -88.89, 16.3 288.42, 76.0 -67.55, -12.21 in-in in 8.848 Saltbr-in 2.579 HRD-na-A -70.76, -46.92 73.96, 4.53 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.62, 24.45 APE9-dihe-na -83.53, -155.23 APE8-dihe-in -93.29, 124.33 APE8-rot-in 299.27 APE67-dihe-in -72.17, -10.84 -63.75, -37.33 APE12-dist-in 9.804 APE11-dist-in 8.48 APE10-dist-in 5.367 APE9-dist-in 3.671 R250G None None XRAY 2.2 0.188 0.227 A 313 274 0 0 0 0 [[38, 290]] 1.0 3qf9 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6PCWA P11309 32 305 313.0 O97:500 Type1 Active DFGin 6.128 14.565 BLAminus DFGAsp-rot-in -128.69, 170.24 60.89, 83.86 184.69, 7.6 -89.77, 15.97 285.56, 79.53 -66.69, -14.24 in-in in 8.791 Saltbr-in 2.631 HRD-na-A -73.35, -47.8 66.65, 11.24 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.44, 8.45 APE9-dihe-na -84.75, -155.07 APE8-dihe-in -92.6, 123.69 APE8-rot-in 306.23 APE67-dihe-in -72.6, -7.76 -62.22, -39.85 APE12-dist-in 9.475 APE11-dist-in 8.492 APE10-dist-in 4.562 APE9-dist-in 3.626 None None None XRAY 2.2 0.177 0.226 A 313 273 1 0 0 0 [[38, 290]] 1.0 6pcw CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6PDIA P11309 32 305 313.0 OCJ:501 Type1 Active DFGin 6.128 14.479 BLAminus DFGAsp-rot-in -126.87, 170.77 61.93, 81.48 196.33, -2.98 -89.41, 13.26 285.32, 82.24 -64.21, -18.32 in-in in 8.811 Saltbr-in 2.62 HRD-na-A -69.88, -49.72 68.62, 9.34 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.35, 18.43 APE9-dihe-na -84.8, -157.57 APE8-dihe-in -92.5, 120.51 APE8-rot-in 302.8 APE67-dihe-in -73.34, -11.57 -60.21, -38.03 APE12-dist-in 9.582 APE11-dist-in 8.369 APE10-dist-in 4.97 APE9-dist-in 3.67 None None None XRAY 1.85 0.163 0.193 A 313 274 0 0 0 0 [[38, 290]] 1.0 6pdi CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6PDNA P11309 32 305 313.0 OD4:900 Type1 Active DFGin 6.303 14.679 BLAminus DFGAsp-rot-in -127.91, 168.34 63.69, 84.1 191.6, 0.16 -90.47, 15.7 284.14, 84.0 -75.26, -13.52 in-in in 8.827 Saltbr-in 2.587 HRD-na-A -70.55, -51.59 71.07, 6.03 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.78, 23.66 APE9-dihe-na -88.42, -164.96 APE8-dihe-in -87.14, 123.03 APE8-rot-in 304.39 APE67-dihe-in -74.69, -11.36 -61.92, -39.09 APE12-dist-in 9.59 APE11-dist-in 8.406 APE10-dist-in 5.053 APE9-dist-in 3.739 None SEP261 SEP261 XRAY 2.4 0.19 0.223 A 313 270 4 0 0 0 [[38, 290]] 1.0 6pdn CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6PDOA P11309 35 305 313.0 OD1:501 Type1 Active DFGin 6.129 14.293 BLAminus DFGAsp-rot-in -134.81, 169.87 61.89, 85.2 188.51, 10.7 -91.49, 10.5 286.61, 82.45 -62.88, -17.93 in-in in 8.588 Saltbr-in 2.752 HRD-na-A -69.22, -51.16 69.51, 6.24 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.34, 22.85 APE9-dihe-na -86.44, -166.55 APE8-dihe-in -83.99, 120.38 APE8-rot-in 303.74 APE67-dihe-in -70.14, -12.44 -58.32, -42.49 APE12-dist-in 9.573 APE11-dist-in 8.362 APE10-dist-in 4.747 APE9-dist-in 3.788 None None None XRAY 2.4 0.177 0.223 A 313 267 4 0 0 0 [[38, 290]] 1.0 6pdo CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6PDPA P11309 36 305 313.0 OBY:502 Type1 Active DFGin 6.15 14.221 BLAminus DFGAsp-rot-in -129.84, 173.21 59.86, 93.48 178.38, 18.04 -102.79, 22.43 282.95, 82.01 -70.26, -12.41 in-in in 8.422 Saltbr-in 2.786 HRD-na-A -67.94, -55.57 82.45, -11.52 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.22, 34.63 APE9-dihe-na -88.55, -154.18 APE8-dihe-in -92.87, 123.61 APE8-rot-in 300.67 APE67-dihe-in -66.54, -13.53 -62.56, -42.85 APE12-dist-in 9.702 APE11-dist-in 8.577 APE10-dist-in 5.713 APE9-dist-in 4.111 None None None XRAY 2.5 0.195 0.23 A 313 268 2 0 0 0 [[38, 290]] 1.0 6pdp CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6QXKB P11309 35 305 313.0 JKW:401 Type1 Active DFGin 6.101 14.609 BLAminus DFGAsp-rot-in -124.57, 170.74 63.53, 81.45 197.18, -4.01 -86.73, 15.75 286.17, 80.26 -64.12, -13.74 in-in in 8.945 Saltbr-in 2.648 HRD-na-A -69.55, -43.65 65.58, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.01, 26.44 APE9-dihe-na -78.6, -156.19 APE8-dihe-in -94.84, 121.84 APE8-rot-in 303.08 APE67-dihe-in -71.43, -12.21 -59.33, -38.29 APE12-dist-in 9.819 APE11-dist-in 8.489 APE10-dist-in 5.419 APE9-dist-in 3.614 None None None XRAY 2.1 0.177 0.201 B 313 269 2 0 0 0 [[38, 290]] 1.0 6qxk CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA P11309 33 305 313.0 XGF:405 Type1 Active DFGin 5.997 14.384 BLAminus DFGAsp-rot-in -131.73, 166.77 65.97, 82.46 200.72, -13.28 -89.79, 16.41 289.35, 79.56 -63.02, -16.4 in-in in 8.812 Saltbr-in 2.643 HRD-na-A -73.15, -45.35 65.43, 10.88 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.23, 17.26 APE9-dihe-na -81.93, -156.28 APE8-dihe-in -91.39, 121.88 APE8-rot-in 296.84 APE67-dihe-in -71.92, -8.94 -64.52, -38.27 APE12-dist-in 9.559 APE11-dist-in 8.479 APE10-dist-in 5.116 APE9-dist-in 3.713 R250G SEP261 SEP261 XRAY 1.95 0.167 0.201 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r0w CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0YA P11309 33 305 313.0 XH3:402 Type1 Active DFGin 6.128 14.537 BLAminus DFGAsp-rot-in -126.73, 169.7 64.58, 82.54 195.52, -0.73 -91.76, 17.79 287.7, 78.06 -67.67, -13.51 in-in in 8.957 Saltbr-in 2.64 HRD-na-A -71.78, -46.47 66.88, 6.9 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.85, 18.81 APE9-dihe-na -78.72, -154.37 APE8-dihe-in -95.58, 121.63 APE8-rot-in 303.84 APE67-dihe-in -73.42, -9.78 -59.84, -39.22 APE12-dist-in 9.539 APE11-dist-in 8.554 APE10-dist-in 5.129 APE9-dist-in 3.718 R250G SEP261 SEP261 XRAY 2.05 0.176 0.19 A 313 271 2 0 0 0 [[38, 290]] 1.0 8r0y CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R10A P11309 33 305 313.0 XGQ:401 Type1 Active DFGin 6.008 14.59 BLAminus DFGAsp-rot-in -125.35, 178.02 53.25, 82.24 190.6, -0.7 -86.16, 17.78 284.81, 76.38 -68.05, -10.88 in-in in 8.896 Saltbr-in 2.635 HRD-na-A -73.59, -46.61 66.3, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.14, 17.84 APE9-dihe-na -81.41, -153.47 APE8-dihe-in -91.91, 123.95 APE8-rot-in 303.23 APE67-dihe-in -72.41, -8.02 -63.66, -38.07 APE12-dist-in 9.924 APE11-dist-in 8.479 APE10-dist-in 5.213 APE9-dist-in 3.632 R250G SEP261 SEP261 XRAY 2.2 0.171 0.202 A 313 263 10 0 0 0 [[38, 290]] 1.0 8r10 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R18A P11309 33 305 313.0 XGK:402 Type1 Active DFGin 6.034 14.352 BLAminus DFGAsp-rot-in -124.11, 175.65 61.57, 82.15 193.22, -3.05 -90.26, 19.65 285.44, 75.92 -71.89, -10.87 in-in in 8.826 Saltbr-in 2.59 HRD-na-A -75.08, -45.72 63.91, 12.1 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.79, 24.66 APE9-dihe-na -82.08, -152.26 APE8-dihe-in -93.08, 122.4 APE8-rot-in 301.75 APE67-dihe-in -73.31, -7.85 -63.76, -37.55 APE12-dist-in 9.84 APE11-dist-in 8.595 APE10-dist-in 5.518 APE9-dist-in 3.68 R250G SEP261 SEP261 XRAY 1.89 0.161 0.186 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r18 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R1NA P11309 34 305 313.0 XIT:401 Type1 Active DFGin 6.057 14.547 BLAminus DFGAsp-rot-in -128.21, 174.49 58.15, 82.23 190.82, 4.17 -87.85, 19.59 286.58, 72.67 -72.06, -10.27 in-in in 8.908 Saltbr-in 2.755 HRD-na-A -72.06, -45.87 66.94, 8.6 in-in-in SNCiii in-in ActLoopNT-in 2.769 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 26.14 APE9-dihe-na -82.46, -153.43 APE8-dihe-in -96.65, 123.51 APE8-rot-in 298.16 APE67-dihe-in -70.63, -8.19 -63.53, -39.8 APE12-dist-in 9.783 APE11-dist-in 8.62 APE10-dist-in 5.206 APE9-dist-in 3.591 R250G SEP261 SEP261 XRAY 2.21 0.163 0.192 A 313 272 0 0 0 0 [[38, 290]] 1.0 8r1n CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R1PA P11309 33 305 313.0 XIP:401 Type1 Active DFGin 6.066 14.618 BLAminus DFGAsp-rot-in -128.97, 176.78 55.64, 82.37 188.61, -1.79 -89.27, 14.78 284.77, 74.77 -64.96, -11.11 in-in in 8.872 Saltbr-in 2.572 HRD-na-A -73.78, -46.66 71.64, 3.78 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.36, 22.63 APE9-dihe-na -86.45, -148.42 APE8-dihe-in -100.33, 122.66 APE8-rot-in 304.21 APE67-dihe-in -71.49, -6.91 -61.13, -41.84 APE12-dist-in 9.79 APE11-dist-in 8.549 APE10-dist-in 4.924 APE9-dist-in 3.756 R250G SEP261 SEP261 XRAY 2.45 0.178 0.206 A 313 269 4 0 0 0 [[38, 290]] 1.0 8r1p CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R1TA P11309 33 305 313.0 XIJ:402 Type1 Active DFGin 6.129 14.5 BLAminus DFGAsp-rot-in -125.46, 175.2 59.64, 82.38 191.49, -0.16 -89.86, 18.41 286.56, 77.1 -71.67, -11.65 in-in in 8.853 Saltbr-in 2.688 HRD-na-A -72.26, -44.66 65.09, 8.72 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 13.92 APE9-dihe-na -81.53, -153.62 APE8-dihe-in -94.64, 124.09 APE8-rot-in 299.63 APE67-dihe-in -71.25, -8.49 -63.99, -39.26 APE12-dist-in 9.796 APE11-dist-in 8.634 APE10-dist-in 4.952 APE9-dist-in 3.66 R250G SEP261 SEP261 XRAY 2.0 0.16 0.179 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r1t CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R1WA P11309 33 305 313.0 XIW:402 Type1 Active DFGin 6.009 14.627 BLAminus DFGAsp-rot-in -126.26, 175.45 55.83, 87.17 192.13, -1.78 -92.67, 17.42 288.58, 76.06 -64.09, -13.07 in-in in 9.012 Saltbr-in 2.642 HRD-na-A -70.36, -47.52 67.35, 8.76 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.05, 16.58 APE9-dihe-na -79.71, -155.45 APE8-dihe-in -91.51, 124.54 APE8-rot-in 299.68 APE67-dihe-in -71.95, -9.45 -64.13, -40.15 APE12-dist-in 9.739 APE11-dist-in 8.566 APE10-dist-in 5.134 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.176 0.204 A 313 270 3 0 0 0 [[38, 290]] 1.0 8r1w CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R25A P11309 33 305 313.0 XJL:402 Type1 Active DFGin 6.224 14.603 BLAminus DFGAsp-rot-in -130.14, 174.3 56.41, 81.8 195.27, 3.56 -90.04, 19.15 286.56, 75.38 -70.08, -10.25 in-in in 9.065 Saltbr-in 2.474 HRD-na-A -71.77, -46.38 67.37, 8.2 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.33, 17.96 APE9-dihe-na -81.3, -151.78 APE8-dihe-in -98.77, 123.36 APE8-rot-in 301.63 APE67-dihe-in -70.17, -10.17 -64.54, -39.25 APE12-dist-in 9.68 APE11-dist-in 8.687 APE10-dist-in 4.963 APE9-dist-in 3.655 R250G SEP261 SEP261 XRAY 2.1 0.178 0.208 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r25 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R27A P11309 33 305 313.0 XJW:402 Type1 Active DFGin 6.013 14.384 BLAminus DFGAsp-rot-in -125.88, 174.13 60.12, 79.82 193.25, -6.34 -86.61, 17.63 284.74, 75.1 -73.25, -8.78 in-in in 8.88 Saltbr-in 2.703 HRD-na-A -74.94, -45.68 65.39, 9.33 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.2, 23.86 APE9-dihe-na -82.24, -153.87 APE8-dihe-in -93.36, 121.12 APE8-rot-in 300.79 APE67-dihe-in -70.77, -7.65 -61.34, -41.5 APE12-dist-in 9.782 APE11-dist-in 8.526 APE10-dist-in 5.256 APE9-dist-in 3.698 R250G SEP261 SEP261 XRAY 1.95 0.166 0.192 A 313 272 1 0 0 0 [[38, 290]] 1.0 8r27 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BIKB P11309 33 305 313.0 BI1:1306 Type1 Active DFGin 6.208 14.854 BLAminus DFGAsp-rot-in -129.68, 166.2 65.31, 82.3 195.4, -5.81 -90.49, 20.51 284.24, 80.72 -71.93, -11.81 in-in in 8.732 Saltbr-in 2.772 HRD-na-A -71.08, -48.28 72.24, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.84, 26.95 APE9-dihe-na -83.77, -163.0 APE8-dihe-in -86.27, 123.71 APE8-rot-in 311.31 APE67-dihe-in -70.32, -9.34 -58.19, -44.58 APE12-dist-in 9.553 APE11-dist-in 8.686 APE10-dist-in 5.627 APE9-dist-in 3.928 None SEP261 SEP261 XRAY 1.8 0.159 0.183 B 313 273 0 0 0 0 [[38, 290]] 1.0 2bik CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BILB P11309 33 306 313.0 BI1:1307 Type1 Active DFGin 5.907 14.641 BLAminus DFGAsp-rot-in -131.58, 166.0 69.48, 82.95 196.44, -4.64 -91.3, 19.54 286.18, 78.18 -74.97, -10.91 in-in in 8.785 Saltbr-in 2.635 HRD-na-A -70.92, -50.11 73.56, 6.45 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.49, 48.23 APE9-dihe-na -87.89, -146.11 APE8-dihe-in -91.43, 121.08 APE8-rot-in 306.95 APE67-dihe-in -71.1, -13.65 -55.02, -40.77 APE12-dist-in 9.462 APE11-dist-in 8.252 APE10-dist-in 6.34 APE9-dist-in 3.858 None None None XRAY 2.55 0.195 0.248 B 313 274 0 0 0 0 [[38, 290]] 1.0 2bil CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZHB P11309 32 306 313.0 HB1:1307 Type1 Active DFGin 6.241 14.717 BLAminus DFGAsp-rot-in -128.91, 169.67 62.16, 81.6 192.04, 4.78 -86.25, 13.92 287.87, 80.39 -66.46, -13.69 in-in in 8.833 Saltbr-in 2.788 HRD-na-A -70.2, -46.33 68.04, 6.62 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 27.94 APE9-dihe-na -80.38, -157.42 APE8-dihe-in -90.55, 119.15 APE8-rot-in 302.06 APE67-dihe-in -68.66, -8.15 -56.91, -42.45 APE12-dist-in 9.582 APE11-dist-in 8.531 APE10-dist-in 5.595 APE9-dist-in 3.673 R250G None None XRAY 1.9 0.159 0.19 B 313 275 0 0 0 0 [[38, 290]] 1.0 2bzh CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZIB P11309 33 305 313.0 DW2:1306 Type1 Active DFGin 6.267 14.835 BLAminus DFGAsp-rot-in -123.34, 165.34 66.36, 86.11 194.72, 5.76 -93.21, 22.23 286.33, 78.94 -70.39, -16.59 in-in in 8.873 Saltbr-in 2.78 HRD-na-A -72.04, -45.2 68.6, 5.31 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.77, 39.69 APE9-dihe-na -92.21, -159.18 APE8-dihe-in -82.89, 124.01 APE8-rot-in 305.62 APE67-dihe-in -65.59, -13.31 -61.02, -47.85 APE12-dist-in 9.456 APE11-dist-in 8.486 APE10-dist-in 5.692 APE9-dist-in 3.938 R250G SEP261 SEP261 XRAY 1.9 0.218 0.265 B 313 273 0 0 0 0 [[38, 290]] 1.0 2bzi CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZJA P11309 33 305 313.0 ME3:1306 Type1 Active DFGin 6.294 14.846 BLAminus DFGAsp-rot-in -129.09, 166.61 64.15, 83.62 198.27, -3.06 -93.36, 13.13 283.19, 80.4 -68.93, -14.93 in-in in 8.914 Saltbr-in 2.525 HRD-na-A -66.52, -47.22 65.13, 9.09 in-in-in SNCiii in-in ActLoopNT-in 2.773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.4, 32.87 APE9-dihe-na -91.23, -169.99 APE8-dihe-in -72.16, 120.4 APE8-rot-in 307.22 APE67-dihe-in -77.22, -2.13 -52.79, -48.09 APE12-dist-in 9.319 APE11-dist-in 8.75 APE10-dist-in 5.528 APE9-dist-in 3.984 R250G None None XRAY 2.05 0.185 0.221 A 313 273 0 0 0 0 [[38, 290]] 1.0 2bzj CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2C3IB P11309 37 305 313.0 IYZ:1306 Type1 Active DFGin 6.326 14.753 BLAminus DFGAsp-rot-in -127.31, 169.9 65.35, 81.96 196.68, 14.61 -93.82, 15.98 286.0, 76.19 -64.86, -18.96 in-in in 8.592 Saltbr-in 2.708 HRD-na-A -73.6, -47.48 67.75, 10.67 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.67, 24.77 APE9-dihe-na -79.26, -156.38 APE8-dihe-in -92.5, 121.61 APE8-rot-in 301.77 APE67-dihe-in -67.73, -10.57 -57.93, -41.83 APE12-dist-in 9.52 APE11-dist-in 8.565 APE10-dist-in 5.327 APE9-dist-in 3.777 R250G None None XRAY 1.9 0.187 0.219 B 313 266 3 0 0 0 [[38, 290]] 1.0 2c3i CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2OI4X P11309 32 306 313.0 JM1:1000 Type1 Active DFGin 6.345 14.812 BLAminus DFGAsp-rot-in -127.98, 160.81 73.35, 71.74 192.68, 9.57 -86.12, 11.96 287.24, 83.24 -76.7, -11.05 in-in in 9.052 Saltbr-in 2.725 HRD-na-A -64.97, -46.27 67.59, 4.83 in-in-in SNCiii in-in ActLoopNT-in 2.781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.16, 42.39 APE9-dihe-na -92.81, -143.09 APE8-dihe-in -99.99, 118.85 APE8-rot-in 297.17 APE67-dihe-in -72.38, -14.41 -46.73, -45.08 APE12-dist-in 9.459 APE11-dist-in 8.866 APE10-dist-in 5.992 APE9-dist-in 3.671 R250G None None XRAY 2.2 0.192 0.244 X 313 275 0 0 0 0 [[38, 290]] 1.0 2oi4 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3BWFA P11309 33 305 313.0 DWC:315 Type1 Active DFGin 6.152 14.761 BLAminus DFGAsp-rot-in -130.15, 160.75 70.46, 85.62 194.77, 2.34 -95.56, 18.11 287.26, 79.6 -68.63, -18.22 in-in in 9.04 Saltbr-in 2.643 HRD-na-A -63.89, -51.3 70.35, 5.77 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.65, 13.48 APE9-dihe-na -90.68, -158.0 APE8-dihe-in -83.6, 122.9 APE8-rot-in 307.99 APE67-dihe-in -60.33, -14.69 -56.04, -57.34 APE12-dist-in 9.248 APE11-dist-in 8.659 APE10-dist-in 5.096 APE9-dist-in 3.904 R250G None None XRAY 2.35 0.171 0.225 A 313 273 0 0 0 0 [[38, 290]] 1.0 3bwf CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5MZLA P11309 33 305 313.0 8ET:401 Type1 Active DFGin 6.07 14.414 BLAminus DFGAsp-rot-in -131.62, 169.01 61.49, 83.12 194.53, -2.68 -91.63, 17.39 285.49, 78.9 -67.71, -14.16 in-in in 8.766 Saltbr-in 2.589 HRD-na-A -71.92, -48.75 69.25, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.79, 22.06 APE9-dihe-na -80.91, -155.94 APE8-dihe-in -90.97, 120.03 APE8-rot-in 302.78 APE67-dihe-in -70.3, -10.66 -61.44, -39.24 APE12-dist-in 9.734 APE11-dist-in 8.509 APE10-dist-in 5.304 APE9-dist-in 3.696 R250G None None XRAY 1.955 0.158 0.183 A 313 269 4 0 0 0 [[38, 290]] 1.0 5mzl CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4NA P11309 33 305 313.0 8M8:401 Type1 Active DFGin 6.125 14.617 BLAminus DFGAsp-rot-in -129.29, 170.82 62.47, 79.55 194.24, 3.91 -88.93, 16.9 284.33, 80.08 -68.56, -10.77 in-in in 8.932 Saltbr-in 2.54 HRD-na-A -74.48, -44.52 65.43, 11.21 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.35, 17.93 APE9-dihe-na -79.41, -153.04 APE8-dihe-in -96.16, 122.12 APE8-rot-in 301.83 APE67-dihe-in -69.32, -12.36 -62.25, -40.05 APE12-dist-in 9.6 APE11-dist-in 8.571 APE10-dist-in 5.203 APE9-dist-in 3.704 R250G None None XRAY 2.09 0.161 0.188 A 313 273 0 0 0 0 [[38, 290]] 1.0 5n4n CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4OA P11309 33 305 313.0 8MB:401 Type1 Active DFGin 6.1 14.601 BLAminus DFGAsp-rot-in -128.07, 170.32 63.44, 81.51 192.09, 2.93 -90.0, 20.39 288.36, 74.25 -70.54, -10.71 in-in in 8.824 Saltbr-in 2.52 HRD-na-A -74.44, -43.81 65.23, 5.78 in-in-in SNCiii in-in ActLoopNT-in 2.781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.86, 22.33 APE9-dihe-na -84.24, -148.33 APE8-dihe-in -98.01, 118.97 APE8-rot-in 304.06 APE67-dihe-in -72.76, -7.0 -59.82, -38.64 APE12-dist-in 9.676 APE11-dist-in 8.64 APE10-dist-in 5.192 APE9-dist-in 3.749 R250G None None XRAY 2.22 0.182 0.196 A 313 271 2 0 0 0 [[38, 290]] 1.0 5n4o CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4UA P11309 34 305 313.0 8MZ:401 Type1 Active DFGin 6.171 14.623 BLAminus DFGAsp-rot-in -127.06, 173.77 59.59, 86.28 190.52, 2.31 -91.8, 19.55 284.63, 76.39 -67.81, -14.94 in-in in 8.939 Saltbr-in 2.663 HRD-na-A -76.79, -43.95 67.64, 10.17 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.95, 11.58 APE9-dihe-na -74.78, -161.25 APE8-dihe-in -87.42, 123.39 APE8-rot-in 302.63 APE67-dihe-in -68.48, -11.24 -64.0, -41.0 APE12-dist-in 9.566 APE11-dist-in 8.431 APE10-dist-in 5.118 APE9-dist-in 3.636 R250G None None XRAY 2.202 0.165 0.198 A 313 272 0 0 0 0 [[38, 290]] 1.0 5n4u CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4VA P11309 33 305 313.0 8MW:401 Type1 Active DFGin 6.186 14.585 BLAminus DFGAsp-rot-in -124.08, 176.44 56.8, 80.25 195.24, -4.47 -87.01, 16.92 283.21, 72.16 -68.4, -12.83 in-in in 8.9 Saltbr-in 2.628 HRD-na-A -74.68, -46.5 67.92, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.8, 18.81 APE9-dihe-na -79.43, -156.57 APE8-dihe-in -90.82, 123.02 APE8-rot-in 301.39 APE67-dihe-in -72.01, -7.09 -64.55, -37.95 APE12-dist-in 9.864 APE11-dist-in 8.573 APE10-dist-in 5.396 APE9-dist-in 3.654 R250G None None XRAY 1.85 0.165 0.187 A 313 273 0 0 0 0 [[38, 290]] 1.0 5n4v CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4YA P11309 33 305 313.0 8N5:401 Type1 Active DFGin 6.042 14.724 BLAminus DFGAsp-rot-in -130.6, 168.91 64.51, 83.34 207.08, -22.98 -90.72, 17.65 288.76, 80.39 -65.28, -8.11 in-in in 9.034 Saltbr-in 2.965 HRD-na-A -68.66, -50.14 72.28, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.0, 26.36 APE9-dihe-na -86.43, -160.39 APE8-dihe-in -83.05, 121.49 APE8-rot-in 308.67 APE67-dihe-in -70.07, -12.6 -65.48, -36.81 APE12-dist-in 9.829 APE11-dist-in 8.51 APE10-dist-in 5.511 APE9-dist-in 3.916 R250G None None XRAY 2.56 0.177 0.218 A 313 273 0 0 0 0 [[38, 290]] 1.0 5n4y CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N4ZA P11309 34 305 313.0 8MK:401 Type1 Active DFGin 6.093 14.586 BLAminus DFGAsp-rot-in -128.45, 169.26 63.69, 88.15 190.47, 2.11 -96.51, 19.04 288.58, 75.49 -67.41, -11.99 in-in in 8.966 Saltbr-in 2.572 HRD-na-A -72.17, -46.94 66.82, 8.56 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 24.78 APE9-dihe-na -81.23, -155.7 APE8-dihe-in -89.42, 121.2 APE8-rot-in 306.52 APE67-dihe-in -67.82, -10.0 -59.95, -43.55 APE12-dist-in 9.578 APE11-dist-in 8.528 APE10-dist-in 5.381 APE9-dist-in 3.713 R250G None None XRAY 2.257 0.18 0.208 A 313 272 0 0 0 0 [[38, 290]] 1.0 5n4z CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N50A P11309 33 305 313.0 8MN:401 Type1 Active DFGin 6.04 14.667 BLAminus DFGAsp-rot-in -127.77, 166.5 68.05, 82.07 199.39, -13.7 -89.1, 18.46 287.73, 79.6 -66.42, -13.96 in-in in 8.921 Saltbr-in 2.554 HRD-na-A -72.47, -47.69 66.88, 11.1 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.17, 14.92 APE9-dihe-na -76.58, -153.55 APE8-dihe-in -94.04, 123.44 APE8-rot-in 302.17 APE67-dihe-in -70.74, -9.3 -65.25, -38.14 APE12-dist-in 9.567 APE11-dist-in 8.494 APE10-dist-in 5.16 APE9-dist-in 3.677 R250G None None XRAY 1.92 0.16 0.18 A 313 273 0 0 0 0 [[38, 290]] 1.0 5n50 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N51A P11309 33 305 313.0 8N8:401 Type1 Active DFGin 6.14 14.626 BLAminus DFGAsp-rot-in -127.02, 176.35 56.56, 82.77 193.62, 3.46 -90.34, 20.5 285.79, 74.98 -67.87, -15.26 in-in in 8.787 Saltbr-in 2.645 HRD-na-A -74.16, -46.81 67.83, 8.58 in-in-in SNCiii in-in ActLoopNT-in 2.802 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.83, 20.8 APE9-dihe-na -83.46, -153.2 APE8-dihe-in -92.57, 121.76 APE8-rot-in 302.99 APE67-dihe-in -70.78, -10.06 -61.78, -40.18 APE12-dist-in 9.722 APE11-dist-in 8.541 APE10-dist-in 5.163 APE9-dist-in 3.737 R250G SEP261 SEP261 XRAY 2.118 0.182 0.207 A 313 269 4 0 0 0 [[38, 290]] 1.0 5n51 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N52A P11309 33 305 313.0 8N2:401 Type1 Active DFGin 6.054 14.495 BLAminus DFGAsp-rot-in -128.92, 172.68 61.78, 83.49 190.01, -0.31 -88.53, 18.1 285.87, 76.88 -62.86, -14.96 in-in in 8.879 Saltbr-in 2.8 HRD-na-A -72.66, -45.02 65.77, 9.07 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.64, 23.49 APE9-dihe-na -83.54, -155.05 APE8-dihe-in -91.57, 124.16 APE8-rot-in 301.67 APE67-dihe-in -71.63, -7.35 -64.67, -40.35 APE12-dist-in 9.776 APE11-dist-in 8.576 APE10-dist-in 5.282 APE9-dist-in 3.676 R250G None None XRAY 2.252 0.172 0.21 A 313 268 5 0 0 0 [[38, 290]] 1.0 5n52 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5N5MA P11309 33 305 313.0 8O8:401 Type1 Active DFGin 6.095 14.721 BLAminus DFGAsp-rot-in -128.4, 173.39 60.49, 81.96 190.9, 9.18 -90.76, 15.73 290.29, 74.98 -68.5, -8.46 in-in in 9.007 Saltbr-in 2.775 HRD-na-A -74.58, -47.17 67.22, 7.63 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.85, 20.79 APE9-dihe-na -81.68, -154.64 APE8-dihe-in -91.98, 123.1 APE8-rot-in 303.04 APE67-dihe-in -72.34, -6.29 -62.86, -39.4 APE12-dist-in 9.645 APE11-dist-in 8.515 APE10-dist-in 5.242 APE9-dist-in 3.667 R250G SEP261 SEP261 XRAY 2.21 0.168 0.205 A 313 273 0 0 0 0 [[38, 290]] 1.0 5n5m CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 5NDTA P11309 33 305 313.0 8UB:402 Type1 Active DFGin 6.114 14.705 BLAminus DFGAsp-rot-in -128.77, 171.81 63.42, 78.28 191.12, 9.72 -87.87, 17.81 284.74, 79.81 -71.9, -9.72 in-in in 8.882 Saltbr-in 2.632 HRD-na-A -72.09, -45.67 67.68, 10.44 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.91, 24.5 APE9-dihe-na -81.02, -156.58 APE8-dihe-in -91.09, 121.22 APE8-rot-in 302.75 APE67-dihe-in -68.43, -10.6 -60.72, -41.46 APE12-dist-in 9.788 APE11-dist-in 8.584 APE10-dist-in 5.402 APE9-dist-in 3.719 R250G None None XRAY 1.985 0.162 0.194 A 313 273 0 0 0 0 [[38, 290]] 1.0 5ndt CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 7Z6UA P11309 33 305 313.0 IJB:402 Type1 Active DFGin 6.271 14.492 BLAminus DFGAsp-rot-in -123.62, 176.91 53.69, 81.97 189.66, 4.28 -85.84, 21.16 285.55, 68.27 -70.71, -12.85 in-in in 8.743 Saltbr-in 2.768 HRD-na-A -72.34, -45.38 65.34, 4.41 in-in-in SNCiii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.54, 10.63 APE9-dihe-na -83.63, -150.44 APE8-dihe-in -98.54, 120.92 APE8-rot-in 299.64 APE67-dihe-in -72.4, -8.48 -60.83, -39.47 APE12-dist-in 9.77 APE11-dist-in 8.63 APE10-dist-in 4.666 APE9-dist-in 3.71 R250G SEP261 SEP261 XRAY 2.28 0.163 0.191 A 313 268 5 0 0 0 [[38, 290]] 1.0 7z6u CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3CXWA P11309 33 306 313.0 7CP:501 Type1 Active DFGin 6.154 14.617 BLAminus DFGAsp-rot-in -123.7, 175.96 66.3, 77.59 193.71, -6.05 -92.53, 20.47 286.96, 76.96 -73.25, -11.74 in-in in 8.91 Saltbr-in 2.628 HRD-na-A -73.02, -49.99 67.21, 12.05 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.29, 21.64 APE9-dihe-na -81.37, -152.87 APE8-dihe-in -93.72, 121.7 APE8-rot-in 305.98 APE67-dihe-in -70.04, -11.91 -61.57, -39.54 APE12-dist-in 9.572 APE11-dist-in 8.397 APE10-dist-in 5.289 APE9-dist-in 3.621 R250G None None XRAY 2.1 0.166 0.206 A 314 272 2 0 0 0 [[38, 290]] 1.0 3cxw CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3CY2A P11309 33 305 313.0 MB9:501 Type1 Active DFGin 6.163 14.645 BLAminus DFGAsp-rot-in -126.41, 176.21 64.46, 78.27 189.52, -4.81 -92.72, 18.89 288.13, 73.75 -67.98, -11.93 in-in in 8.905 Saltbr-in 2.568 HRD-na-A -71.13, -52.84 70.37, 7.17 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.27, 21.57 APE9-dihe-na -78.39, -153.2 APE8-dihe-in -93.22, 122.03 APE8-rot-in 307.28 APE67-dihe-in -67.99, -12.82 -60.45, -42.49 APE12-dist-in 9.543 APE11-dist-in 8.479 APE10-dist-in 5.395 APE9-dist-in 3.557 R250G None None XRAY 2.01 0.169 0.199 A 314 271 2 0 0 0 [[38, 290]] 1.0 3cy2 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3CY3A P11309 33 305 313.0 JN5:501 Type1 Active DFGin 6.303 14.419 BLAminus DFGAsp-rot-in -119.65, 175.12 56.83, 74.92 197.23, 3.13 -82.21, 12.5 285.74, 75.76 -70.58, -7.45 in-in in 8.756 Saltbr-in 2.56 HRD-na-A -67.55, -45.89 68.27, 6.37 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.11, 26.07 APE9-dihe-na -79.4, -161.09 APE8-dihe-in -89.18, 123.7 APE8-rot-in 304.7 APE67-dihe-in -65.31, -15.75 -62.09, -40.0 APE12-dist-in 9.675 APE11-dist-in 8.486 APE10-dist-in 5.567 APE9-dist-in 3.623 R250G SEP261 SEP261 XRAY 2.15 0.165 0.205 A 314 271 2 0 0 0 [[38, 290]] 1.0 3cy3 CAMK_PIM1_HUMAN CAMK 1.6e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4RPVA P11309 33 305 313.0 3UR:401 Type1 Active DFGin 5.958 14.854 BLAminus DFGAsp-rot-in -145.63, 161.43 69.99, 88.37 210.94, -4.91 -103.98, 21.07 280.48, 100.64 -81.25, 11.11 in-in in 8.944 Saltbr-in 2.804 HRD-na-A -54.49, -51.71 77.62, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.601 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 30.75 APE9-dihe-na -100.7, -169.57 APE8-dihe-in -63.18, 128.08 APE8-rot-in 302.06 APE67-dihe-in -40.53, -14.86 -60.72, -74.04 APE12-dist-in 9.591 APE11-dist-in 8.895 APE10-dist-in 5.655 APE9-dist-in 4.153 None None None XRAY 3.05 0.229 0.273 A 410 273 0 0 0 0 [[38, 290]] 1.0 4rpv CAMK_PIM1_HUMAN CAMK 9.6e-65 224.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA P11309 33 305 313.0 M0F:401 Type1 Active DFGin 6.024 14.406 BLAminus DFGAsp-rot-in -126.46, 177.16 55.61, 83.44 194.1, -9.69 -89.48, 19.88 284.93, 74.96 -67.33, -13.52 in-in in 8.831 Saltbr-in 2.648 HRD-na-A -72.52, -48.51 66.56, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 19.87 APE9-dihe-na -78.39, -149.93 APE8-dihe-in -97.85, 123.61 APE8-rot-in 301.25 APE67-dihe-in -68.16, -10.25 -64.9, -40.75 APE12-dist-in 9.727 APE11-dist-in 8.467 APE10-dist-in 5.304 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.166 0.191 A 309 264 7 0 0 0 [[38, 290]] 1.0 8afr CAMK_PIM1_HUMAN CAMK 3.2e-62 216.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 4ALUA P11309 33 306 313.0 79O:1308 Type1 Active DFGin 6.04 14.455 BLAminus DFGAsp-rot-in -129.3, 164.2 71.61, 87.87 186.32, 5.39 -98.95, 24.33 283.93, 80.99 -80.29, 2.07 in-in in 8.747 Saltbr-in 2.55 HRD-na-A -75.13, -46.19 78.28, -3.97 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.43, 41.36 APE9-dihe-na -93.61, -144.58 APE8-dihe-in -101.6, 125.74 APE8-rot-in 300.81 APE67-dihe-in -62.7, -19.8 -64.97, -44.76 APE12-dist-in 9.623 APE11-dist-in 8.602 APE10-dist-in 5.726 APE9-dist-in 3.781 None None None XRAY 2.6 0.184 0.248 A 328 274 0 0 0 0 [[38, 290]] 1.0 4alu CAMK_PIM1_HUMAN CAMK 2.8e-64 222.9 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3T9IA P11309 33 306 313.0 3T9:401 Type1.5_Back Active DFGin 6.543 14.295 BLAminus DFGAsp-rot-in -132.77, 172.96 59.67, 82.28 190.58, 14.15 -96.48, 17.83 287.7, 76.66 -65.3, -19.74 in-in in 8.435 Saltbr-in 2.757 HRD-na-A -69.28, -50.32 73.93, -9.03 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.31, 28.32 APE9-dihe-na -97.99, -160.13 APE8-dihe-in -83.72, 117.37 APE8-rot-in 302.02 APE67-dihe-in -69.04, -9.18 -56.37, -42.61 APE12-dist-in 9.735 APE11-dist-in 8.656 APE10-dist-in 5.198 APE9-dist-in 4.281 None SEP261 SEP261 XRAY 2.6 0.165 0.227 A 328 274 0 0 0 0 [[38, 290]] 1.0 3t9i CAMK_PIM1_HUMAN CAMK 4.8e-65 225.4 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6AYDA P11309 34 305 313.0 C2J:401 Type1.5_Back Active DFGin 6.225 14.573 BLAminus DFGAsp-rot-in -129.9, 167.94 69.26, 93.71 199.12, -17.78 -101.76, 29.48 284.65, 86.99 -77.7, -11.94 in-in in 8.499 Saltbr-in 2.694 HRD-na-A -64.89, -48.59 73.72, 7.41 in-in-in SNCiii in-in ActLoopNT-in 2.719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.07, 29.72 APE9-dihe-na -90.29, -149.58 APE8-dihe-in -90.3, 121.0 APE8-rot-in 309.33 APE67-dihe-in -70.19, -4.08 -54.85, -49.52 APE12-dist-in 9.757 APE11-dist-in 8.595 APE10-dist-in 5.436 APE9-dist-in 4.066 R250G None None XRAY 3.0 0.171 0.23 A 334 272 0 0 0 0 [[38, 290]] 1.0 6ayd CAMK_PIM1_HUMAN CAMK 1.9e-64 223.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM2 PIM2_HUMAN AF-Q9P1W9-K1A Q9P1W9 24 294 311.0 No_ligand No_ligand Active DFGin 5.981 14.335 BLAminus DFGAsp-rot-in -126.89, 169.76 59.25, 80.5 203.92, -0.99 -87.64, 18.92 284.7, 69.92 -59.97, -36.8 in-in in 8.421 Saltbr-in 2.679 HRD-na-T -75.17, -41.63 62.22, -7.7 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.37, 22.21 APE9-dihe-na -84.18, -176.74 APE8-dihe-in -73.66, 121.18 APE8-rot-in 303.62 APE67-dihe-in -69.59, -15.65 -57.15, -41.47 APE12-dist-in 9.455 APE11-dist-in 8.725 APE10-dist-in 5.139 APE9-dist-in 3.821 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[32, 286]] 1.0 AF-Q9P1W9-K1 CAMK_PIM2_HUMAN CAMK 3.4e-61 212.8 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN AF-Q9P1W9-K3A Q9P1W9 24 294 311.0 No_ligand No_ligand Active DFGin 5.792 13.983 BLAminus DFGAsp-rot-in -128.64, 173.97 56.27, 78.2 203.71, -14.55 -80.94, 17.18 284.85, 73.49 -59.99, -38.55 in-in in 8.261 Saltbr-in 2.667 HRD-na-T -77.09, -36.87 63.05, -18.0 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.04, 8.53 APE9-dihe-na -84.81, 179.89 APE8-dihe-in -75.15, 129.13 APE8-rot-in 296.96 APE67-dihe-in -68.39, -18.9 -58.68, -43.28 APE12-dist-in 9.824 APE11-dist-in 9.247 APE10-dist-in 4.122 APE9-dist-in 3.674 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[32, 286]] 1.0 AF-Q9P1W9-K3 CAMK_PIM2_HUMAN CAMK 3.4e-61 212.8 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN 4X7QB Q9P1W9 27 287 311.0 3YR:401 Type1 Active DFGin 6.127 14.1 BLAminus DFGAsp-rot-in -129.33, 168.29 68.57, 75.13 189.21, 1.85 -88.36, 11.07 283.21, 81.76 -55.7, -17.38 in-in in 8.187 Saltbr-in 2.586 HRD-na-T -70.88, -48.99 70.44, 7.88 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.21, 66.32 APE9-dihe-na -89.41, -159.06 APE8-dihe-in -91.58, 123.37 APE8-rot-in 302.93 APE67-dihe-in -67.71, -12.45 -52.33, -48.23 APE12-dist-in 8.785 APE11-dist-in 8.505 APE10-dist-in 6.402 APE9-dist-in 4.236 None None None XRAY 2.33 0.199 0.258 B 312 243 18 0 0 0 [[32, 286]] 1.0 4x7q CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM3 PIM3_HUMAN AF-Q86V86-K1A Q86V86 32 301 326.0 No_ligand No_ligand Active DFGin 5.955 14.353 BLAminus DFGAsp-rot-in -120.68, 171.65 57.59, 82.22 200.13, -0.45 -88.06, 19.0 284.73, 71.03 -60.51, -32.42 in-in in 8.428 Saltbr-in 2.715 HRD-na-T -74.97, -39.12 62.08, -14.27 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.19, 0.82 APE9-dihe-na -79.91, -177.25 APE8-dihe-in -72.15, 122.43 APE8-rot-in 302.48 APE67-dihe-in -69.8, -14.3 -56.71, -42.04 APE12-dist-in 9.921 APE11-dist-in 8.943 APE10-dist-in 4.412 APE9-dist-in 3.82 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[40, 293]] 1.0 AF-Q86V86-K1 CAMK_PIM3_HUMAN CAMK 2.6e-63 219.7 1 256 256 188 189 190 192 194 69 90 94 167 169 168 170 227 214 209 208 207 206 205 204 203 124 Serine/threonine-protein kinase pim-3
CAMK PIM3 PIM3_HUMAN AF-Q86V86-K3A Q86V86 32 301 326.0 No_ligand No_ligand Active DFGin 5.743 14.133 BLAminus DFGAsp-rot-in -123.8, 175.45 55.29, 77.21 203.96, 1.36 -82.29, 14.48 285.22, 75.71 -58.09, -41.54 in-in in 8.453 Saltbr-in 2.75 HRD-na-T -75.55, -35.88 62.06, -17.33 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.87, 18.52 APE9-dihe-na -85.56, -179.23 APE8-dihe-in -74.34, 122.3 APE8-rot-in 300.7 APE67-dihe-in -69.36, -19.51 -59.0, -40.65 APE12-dist-in 9.565 APE11-dist-in 8.449 APE10-dist-in 4.64 APE9-dist-in 3.993 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[40, 293]] 1.0 AF-Q86V86-K3 CAMK_PIM3_HUMAN CAMK 2.6e-63 219.7 1 256 256 188 189 190 192 194 69 90 94 167 169 168 170 227 214 209 208 207 206 205 204 203 124 Serine/threonine-protein kinase pim-3
CAMK PLK1 PLK1_HUMAN AF-P53350-K1A P53350 45 313 603.0 No_ligand No_ligand Active DFGin 5.55 14.018 BLAminus DFGAsp-rot-in -138.81, -176.13 59.79, 75.65 196.24, 12.57 -83.94, 15.34 292.62, 90.11 -62.81, -20.58 in-in in 9.039 Saltbr-in 2.576 HRD-in -77.19, -43.8 61.96, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 167.37 APE9-dihe-na 111.84, 169.16 APE8-dihe-in -85.0, 135.3 APE8-rot-in 298.31 APE67-dihe-in -79.3, -5.41 -49.93, -42.14 APE12-dist-in 8.648 APE11-dist-in 11.487 APE10-dist-in 5.793 APE9-dist-in 3.502 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K1 CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN AF-P53350-K3A P53350 45 313 603.0 No_ligand No_ligand Active DFGin 5.342 13.979 BLAminus DFGAsp-rot-in -140.81, -172.37 56.25, 72.33 199.46, 12.1 -75.86, 12.77 292.93, 94.61 -62.92, -13.77 in-in in 9.329 Saltbr-in 2.577 HRD-in -78.81, -41.77 63.16, 8.34 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.05, 166.42 APE9-dihe-na 111.25, 170.64 APE8-dihe-in -84.99, 137.05 APE8-rot-in 295.25 APE67-dihe-in -75.5, -4.86 -51.24, -44.46 APE12-dist-in 8.632 APE11-dist-in 11.552 APE10-dist-in 5.872 APE9-dist-in 3.323 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[53, 305]] 1.0 AF-P53350-K3 CAMK_PLK1_HUMAN CAMK 1.5e-79 272.9 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK2 PLK2_HUMAN AF-Q9NYY3-K1A Q9NYY3 74 342 685.0 No_ligand No_ligand Active DFGin 5.878 14.185 BLAminus DFGAsp-rot-in -147.46, -172.71 60.15, 73.84 193.64, 15.71 -80.89, 16.42 293.1, 93.14 -63.43, -14.53 in-in in 8.936 Saltbr-in 2.651 HRD-in -78.87, -46.04 66.59, -4.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 157.05 APE9-dihe-na 115.29, 171.82 APE8-dihe-in -74.81, 123.94 APE8-rot-in 299.76 APE67-dihe-in -69.86, -8.77 -46.74, -44.99 APE12-dist-in 9.951 APE11-dist-in 12.216 APE10-dist-in 6.543 APE9-dist-in 3.666 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[82, 334]] 1.0 AF-Q9NYY3-K1 CAMK_PLK2_HUMAN CAMK 1.7e-81 279.3 1 256 256 222 223 224 226 228 111 130 134 202 204 203 205 262 250 245 244 243 242 241 240 239 160 Serine/threonine-protein kinase PLK2
CAMK PLK2 PLK2_HUMAN AF-Q9NYY3-K3A Q9NYY3 74 342 685.0 No_ligand No_ligand Active DFGin 5.955 14.122 BLAminus DFGAsp-rot-in -152.4, -171.21 58.33, 71.34 188.58, 28.1 -77.58, 15.97 294.56, 96.7 -64.79, -8.59 in-in in 8.911 Saltbr-in 2.649 HRD-in -79.28, -43.99 66.76, -1.47 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.83, 156.71 APE9-dihe-na 116.9, 170.96 APE8-dihe-in -76.79, 125.85 APE8-rot-in 294.92 APE67-dihe-in -70.31, -7.56 -46.09, -47.1 APE12-dist-in 10.098 APE11-dist-in 12.307 APE10-dist-in 6.579 APE9-dist-in 3.453 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[82, 334]] 1.0 AF-Q9NYY3-K3 CAMK_PLK2_HUMAN CAMK 1.7e-81 279.3 1 256 256 222 223 224 226 228 111 130 134 202 204 203 205 262 250 245 244 243 242 241 240 239 160 Serine/threonine-protein kinase PLK2
CAMK PLK3 PLK3_HUMAN AF-Q9H4B4-K1A Q9H4B4 54 322 646.0 No_ligand No_ligand Active DFGin 5.782 14.189 BLAminus DFGAsp-rot-in -147.02, -170.9 60.54, 77.57 193.56, 15.27 -85.52, 15.95 290.73, 90.73 -62.51, -18.24 in-in in 8.961 Saltbr-in 2.659 HRD-in -78.7, -44.31 64.79, 6.8 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, 171.92 APE9-dihe-na 101.97, 168.48 APE8-dihe-in -75.3, 130.49 APE8-rot-in 300.91 APE67-dihe-in -73.34, -6.05 -47.93, -43.24 APE12-dist-in 9.659 APE11-dist-in 12.001 APE10-dist-in 6.237 APE9-dist-in 3.538 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[62, 314]] 1.0 AF-Q9H4B4-K1 CAMK_PLK3_HUMAN CAMK 8.1e-81 277.1 1 256 256 202 203 204 206 208 91 110 114 182 184 183 185 242 230 225 224 223 222 221 220 219 140 Serine/threonine-protein kinase PLK3
CAMK PLK3 PLK3_HUMAN AF-Q9H4B4-K3A Q9H4B4 54 322 646.0 No_ligand No_ligand Active DFGin 5.827 14.01 BLAminus DFGAsp-rot-in -143.4, -168.14 60.09, 68.08 196.2, 22.14 -76.13, 11.49 290.48, 89.02 -63.9, -15.15 in-in in 8.673 Saltbr-in 2.649 HRD-in -80.94, -41.65 64.11, -7.04 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 170.32 APE9-dihe-na 101.66, 176.06 APE8-dihe-in -83.67, 127.01 APE8-rot-in 298.04 APE67-dihe-in -64.92, -8.76 -42.97, -53.91 APE12-dist-in 9.937 APE11-dist-in 12.091 APE10-dist-in 6.335 APE9-dist-in 3.436 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[62, 314]] 1.0 AF-Q9H4B4-K3 CAMK_PLK3_HUMAN CAMK 8.1e-81 277.1 1 256 256 202 203 204 206 208 91 110 114 182 184 183 185 242 230 225 224 223 222 221 220 219 140 Serine/threonine-protein kinase PLK3
CAMK PLK3 PLK3_HUMAN 4B6LA Q9H4B4 52 332 646.0 9ZP:1333 Type1 Active DFGin 5.968 14.596 BLAminus DFGAsp-rot-in -126.6, -175.09 59.05, 88.67 195.65, 4.05 -95.27, 20.82 293.51, 95.43 -57.77, -31.13 in-in in 9.057 Saltbr-in 2.6 HRD-in -72.43, -51.59 74.35, -5.63 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.27, 166.41 APE9-dihe-na 105.64, 157.36 APE8-dihe-in -58.92, 118.97 APE8-rot-in 303.98 APE67-dihe-in -67.63, -20.9 -46.02, -41.54 APE12-dist-in 10.388 APE11-dist-in 12.452 APE10-dist-in 6.788 APE9-dist-in 3.663 None None None XRAY 1.9 0.246 0.289 A 281 281 0 0 0 0 [[62, 314]] 1.0 4b6l CAMK_PLK3_HUMAN CAMK 9.6e-81 276.8 1 256 256 202 203 204 206 208 91 110 114 182 184 183 185 242 230 225 224 223 222 221 220 219 140 Serine/threonine-protein kinase PLK3
CAMK PLK4 PLK4_HUMAN AF-O00444-K1A O00444 4 273 970.0 No_ligand No_ligand Active DFGin 5.822 14.117 BLAminus DFGAsp-rot-in -129.53, 172.92 61.33, 84.61 201.73, -10.06 -89.6, 15.75 296.32, 95.58 -62.23, -22.89 in-in in 9.519 Saltbr-in 2.727 HRD-in -78.84, -43.45 64.52, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.72, 170.94 APE9-dihe-na 93.05, 178.78 APE8-dihe-in -88.37, 133.51 APE8-rot-in 297.58 APE67-dihe-in -78.42, -9.44 -51.65, -34.12 APE12-dist-in 8.86 APE11-dist-in 12.015 APE10-dist-in 6.391 APE9-dist-in 3.577 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[12, 265]] 1.0 AF-O00444-K1 CAMK_PLK4_HUMAN CAMK 4.4e-82 281.2 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN AF-O00444-K3A O00444 4 273 970.0 No_ligand No_ligand Active DFGin 5.846 14.206 BLAminus DFGAsp-rot-in -135.8, 176.64 54.84, 74.9 207.03, -26.86 -75.4, 13.05 295.11, 99.46 -62.65, -21.21 in-in in 9.287 Saltbr-in 2.676 HRD-in -79.41, -43.56 64.15, -9.94 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.02, 171.65 APE9-dihe-na 90.28, 175.76 APE8-dihe-in -84.18, 124.7 APE8-rot-in 297.23 APE67-dihe-in -74.07, -8.36 -50.56, -35.43 APE12-dist-in 9.078 APE11-dist-in 11.876 APE10-dist-in 6.182 APE9-dist-in 3.43 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[12, 265]] 1.0 AF-O00444-K3 CAMK_PLK4_HUMAN CAMK 4.4e-82 281.2 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PNCK KCC1B_HUMAN AF-Q6P2M8-K1A Q6P2M8 7 278 343.0 No_ligand No_ligand Active DFGin 6.95 14.446 BLAminus DFGAsp-rot-in -128.41, 177.36 58.64, 77.01 197.33, 18.2 -86.45, 14.35 287.01, 83.14 -61.28, -25.56 in-in in 9.397 Saltbr-in 2.711 HRD-in -73.6, -47.5 66.49, 1.2 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.49, 169.09 APE9-dihe-na 107.81, 173.56 APE8-dihe-in -86.16, 124.68 APE8-rot-in 304.39 APE67-dihe-in -68.28, -11.26 -36.54, -54.23 APE12-dist-in 9.493 APE11-dist-in 11.736 APE10-dist-in 6.077 APE9-dist-in 3.643 None None None AF2 -1.0 1.0 1.0 A 272 272 0 0 0 0 [[15, 270]] 1.0 AF-Q6P2M8-K1 CAMK_PNCK_HUMAN CAMK 1.8e-92 315.2 1 256 256 156 157 158 160 162 44 61 65 133 135 134 136 194 182 177 176 175 174 173 172 171 91 Calcium/calmodulin-dependent protein kinase type 1B
CAMK PNCK KCC1B_HUMAN AF-Q6P2M8-K3A Q6P2M8 7 278 343.0 No_ligand No_ligand Active DFGin 6.427 14.556 BLAminus DFGAsp-rot-in -136.58, -177.42 47.46, 81.79 203.17, -8.4 -84.4, 11.33 285.26, 86.32 -58.99, -29.89 in-in in 9.312 Saltbr-in 2.731 HRD-in -77.31, -47.54 67.27, -0.92 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.85, 172.64 APE9-dihe-na 105.92, 177.43 APE8-dihe-in -96.17, 128.31 APE8-rot-in 302.72 APE67-dihe-in -67.85, -16.46 -43.91, -46.07 APE12-dist-in 8.983 APE11-dist-in 11.66 APE10-dist-in 6.088 APE9-dist-in 3.684 None None None AF2 -1.0 1.0 1.0 A 272 272 0 0 0 0 [[15, 270]] 1.0 AF-Q6P2M8-K3 CAMK_PNCK_HUMAN CAMK 1.8e-92 315.2 1 256 256 156 157 158 160 162 44 61 65 133 135 134 136 194 182 177 176 175 174 173 172 171 91 Calcium/calmodulin-dependent protein kinase type 1B
CAMK PRKAA1 AAPK1_HUMAN 6C9JA Q13131 22 559 559.0 R34:60601,STU:60602 Allosteric,Type1 Active DFGin 6.98 13.932 BLAminus DFGAsp-rot-in -148.31, -179.86 61.68, 68.06 215.47, -27.58 -82.96, 8.26 285.07, 89.54 -49.65, -37.12 out-in out 10.05 Saltbr-in 3.025 HRD-in -61.18, -61.45 68.18, -7.34 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.03, 155.55 APE9-dihe-na 81.79, 170.06 APE8-dihe-in -65.93, 140.22 APE8-rot-in 298.24 APE67-dihe-in -65.83, -31.14 -52.06, -38.38 APE12-dist-in 8.312 APE11-dist-in 11.199 APE10-dist-in 5.64 APE9-dist-in 4.101 None TPO183 TPO183 XRAY 3.05 0.215 0.225 A 494 384 0 0 0 0 [[27, 279]] 1.0 6c9j CAMK_PRKAA1_HUMAN CAMK 3.8e-89 304.6 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN AF-Q13131-K3A Q13131 19 287 559.0 No_ligand No_ligand Active DFGin 6.501 14.903 BLAminus DFGAsp-rot-in -129.08, -177.68 47.33, 68.2 203.83, 13.5 -74.74, 17.85 288.58, 82.81 -63.19, -24.19 in-in in 9.323 Saltbr-in 2.709 HRD-in -78.49, -48.1 65.48, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.89, 169.2 APE9-dihe-na 88.63, -177.87 APE8-dihe-in -80.88, 127.64 APE8-rot-in 293.69 APE67-dihe-in -63.96, -18.51 -42.59, -48.91 APE12-dist-in 8.22 APE11-dist-in 11.595 APE10-dist-in 6.089 APE9-dist-in 4.45 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[27, 279]] 1.0 AF-Q13131-K3 CAMK_PRKAA1_HUMAN CAMK 5.7e-90 307.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN AF-P54646-K3A P54646 8 276 552.0 No_ligand No_ligand Active DFGin 6.563 14.92 BLAminus DFGAsp-rot-in -128.53, -178.68 49.41, 64.01 206.35, 24.06 -71.26, 17.39 289.31, 83.01 -63.79, -23.37 in-in in 9.271 Saltbr-in 2.712 HRD-in -78.76, -48.2 65.77, -3.54 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.26, 172.51 APE9-dihe-na 85.26, 178.7 APE8-dihe-in -78.18, 130.02 APE8-rot-in 290.49 APE67-dihe-in -66.21, -20.42 -45.29, -46.43 APE12-dist-in 8.35 APE11-dist-in 11.532 APE10-dist-in 6.026 APE9-dist-in 4.309 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[16, 268]] 1.0 AF-P54646-K3 CAMK_PRKAA2_HUMAN CAMK 1.3e-90 309.1 1 256 256 156 157 158 160 162 45 64 68 136 138 137 139 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
CAMK PRKD1 KPCD1_HUMAN AF-Q15139-K1A Q15139 575 847 912.0 No_ligand No_ligand Active DFGin 6.436 14.38 BLAminus DFGAsp-rot-in -134.96, -179.55 52.63, 70.42 201.47, 25.84 -80.02, 20.13 285.49, 76.91 -58.75, -38.23 in-in in 9.043 Saltbr-in 2.666 HRD-in -66.21, -41.43 67.49, -15.13 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.66, 148.54 APE9-dihe-na 97.03, 173.18 APE8-dihe-in -81.05, 133.7 APE8-rot-in 304.05 APE67-dihe-in -66.35, -12.78 -45.2, -50.71 APE12-dist-in 9.018 APE11-dist-in 10.796 APE10-dist-in 5.488 APE9-dist-in 3.559 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[581, 839]] 1.0 AF-Q15139-K1 CAMK_PRKD1_HUMAN CAMK 5.5e-83 284.1 4 256 253 726 727 728 730 732 612 630 634 703 705 704 706 765 753 748 747 746 745 744 743 742 660 Serine/threonine-protein kinase D1
CAMK PRKD1 KPCD1_HUMAN AF-Q15139-K3A Q15139 575 847 912.0 No_ligand No_ligand Active DFGin 6.481 14.653 BLAminus DFGAsp-rot-in -136.61, 179.17 54.66, 73.28 200.62, 11.82 -84.07, 16.36 288.28, 77.63 -55.9, -32.82 in-in in 9.047 Saltbr-in 2.896 HRD-in -71.34, -40.66 67.07, -12.56 in-in-in SNCiii in-in ActLoopNT-in 2.835 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.12, 147.63 APE9-dihe-na 87.93, -173.32 APE8-dihe-in -91.93, 126.05 APE8-rot-in 303.74 APE67-dihe-in -63.41, -16.9 -45.4, -49.59 APE12-dist-in 9.147 APE11-dist-in 10.815 APE10-dist-in 5.276 APE9-dist-in 3.394 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[581, 839]] 1.0 AF-Q15139-K3 CAMK_PRKD1_HUMAN CAMK 5.5e-83 284.1 4 256 253 726 727 728 730 732 612 630 634 703 705 704 706 765 753 748 747 746 745 744 743 742 660 Serine/threonine-protein kinase D1
CAMK PRKD2 KPCD2_HUMAN AF-Q9BZL6-K1A Q9BZL6 543 815 878.0 No_ligand No_ligand Active DFGin 6.459 14.116 BLAminus DFGAsp-rot-in -135.31, 177.86 60.81, 70.93 199.68, 16.5 -83.56, 18.22 286.93, 78.68 -61.3, -28.98 in-in in 9.054 Saltbr-in 2.752 HRD-in -68.24, -43.96 67.76, -9.85 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.17, 150.2 APE9-dihe-na 100.69, -179.47 APE8-dihe-in -89.59, 127.76 APE8-rot-in 303.1 APE67-dihe-in -64.84, -13.46 -43.76, -50.46 APE12-dist-in 9.575 APE11-dist-in 10.925 APE10-dist-in 5.534 APE9-dist-in 3.375 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[549, 807]] 1.0 AF-Q9BZL6-K1 CAMK_PRKD2_HUMAN CAMK 1.2e-82 283.0 4 256 253 694 695 696 698 700 580 598 602 671 673 672 674 733 721 716 715 714 713 712 711 710 628 Serine/threonine-protein kinase D2
CAMK PRKD2 KPCD2_HUMAN AF-Q9BZL6-K3A Q9BZL6 543 815 878.0 No_ligand No_ligand Active DFGin 6.336 14.48 BLAminus DFGAsp-rot-in -135.63, -177.27 53.26, 70.51 198.63, 20.34 -82.77, 17.23 289.22, 81.16 -58.19, -35.43 in-in in 8.987 Saltbr-in 2.782 HRD-in -71.94, -41.64 67.77, -0.87 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.27, 148.16 APE9-dihe-na 91.64, 177.01 APE8-dihe-in -86.98, 135.01 APE8-rot-in 301.59 APE67-dihe-in -67.12, -15.02 -45.17, -50.78 APE12-dist-in 9.342 APE11-dist-in 10.633 APE10-dist-in 5.474 APE9-dist-in 3.123 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[549, 807]] 1.0 AF-Q9BZL6-K3 CAMK_PRKD2_HUMAN CAMK 1.2e-82 283.0 4 256 253 694 695 696 698 700 580 598 602 671 673 672 674 733 721 716 715 714 713 712 711 710 628 Serine/threonine-protein kinase D2
CAMK PRKD3 KPCD3_HUMAN AF-O94806-K1A O94806 568 840 890.0 No_ligand No_ligand Active DFGin 6.443 14.347 BLAminus DFGAsp-rot-in -134.9, -179.86 53.13, 71.62 201.37, 24.46 -80.77, 19.88 285.23, 77.81 -58.7, -38.08 in-in in 9.011 Saltbr-in 2.657 HRD-in -65.95, -41.58 67.3, -14.43 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.23, 147.99 APE9-dihe-na 97.49, 173.8 APE8-dihe-in -81.44, 133.5 APE8-rot-in 303.96 APE67-dihe-in -66.42, -12.39 -44.94, -51.03 APE12-dist-in 8.966 APE11-dist-in 10.808 APE10-dist-in 5.484 APE9-dist-in 3.556 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[574, 832]] 1.0 AF-O94806-K1 CAMK_PRKD3_HUMAN CAMK 6e-82 280.8 4 256 253 719 720 721 723 725 605 623 627 696 698 697 699 758 746 741 740 739 738 737 736 735 653 Serine/threonine-protein kinase D3
CAMK PRKD3 KPCD3_HUMAN AF-O94806-K3A O94806 568 840 890.0 No_ligand No_ligand Active DFGin 6.598 14.439 BLAminus DFGAsp-rot-in -135.88, -174.87 49.26, 70.22 200.95, 11.39 -83.25, 17.05 290.13, 80.44 -56.27, -36.36 in-in in 9.003 Saltbr-in 2.967 HRD-in -68.86, -39.35 64.94, 1.42 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.41, 159.36 APE9-dihe-na 73.65, -173.56 APE8-dihe-in -90.6, 120.63 APE8-rot-in 302.13 APE67-dihe-in -62.41, -17.78 -47.97, -45.86 APE12-dist-in 9.223 APE11-dist-in 10.645 APE10-dist-in 5.268 APE9-dist-in 3.286 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[574, 832]] 1.0 AF-O94806-K3 CAMK_PRKD3_HUMAN CAMK 6e-82 280.8 4 256 253 719 720 721 723 725 605 623 627 696 698 697 699 758 746 741 740 739 738 737 736 735 653 Serine/threonine-protein kinase D3
CAMK PSKH1 KPSH1_HUMAN AF-P11801-K1A P11801 90 363 424.0 No_ligand No_ligand Active DFGin 6.918 13.763 BLAminus DFGAsp-rot-in -128.76, 171.25 62.67, 77.79 201.62, 8.73 -89.16, 18.53 295.62, 95.3 -61.09, -30.34 in-in in 7.976 Saltbr-in 2.729 HRD-in -75.67, -44.36 63.35, 9.49 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.47, 170.14 APE9-dihe-na 111.61, 174.53 APE8-dihe-in -85.7, 123.63 APE8-rot-in 302.9 APE67-dihe-in -74.21, -19.88 -44.55, -41.47 APE12-dist-in 8.857 APE11-dist-in 11.455 APE10-dist-in 5.786 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-P11801-K1 CAMK_PSKH1_HUMAN CAMK 3.9e-92 314.1 1 256 256 238 239 240 242 244 127 143 147 215 217 216 218 279 267 262 261 260 259 258 257 256 173 Serine/threonine-protein kinase H1
CAMK PSKH1 KPSH1_HUMAN AF-P11801-K3A P11801 90 363 424.0 No_ligand No_ligand Active DFGin 6.607 13.655 BLAminus DFGAsp-rot-in -134.27, -177.39 59.39, 65.58 203.27, 11.02 -79.09, 18.19 296.83, 100.52 -58.41, -33.68 in-in in 7.86 Saltbr-in 2.734 HRD-in -78.29, -45.12 64.34, 6.64 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.25, 171.23 APE9-dihe-na 112.92, 165.34 APE8-dihe-in -72.35, 133.0 APE8-rot-in 298.44 APE67-dihe-in -84.43, -17.54 -55.03, -34.85 APE12-dist-in 8.542 APE11-dist-in 11.579 APE10-dist-in 5.921 APE9-dist-in 3.388 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-P11801-K3 CAMK_PSKH1_HUMAN CAMK 3.9e-92 314.1 1 256 256 238 239 240 242 244 127 143 147 215 217 216 218 279 267 262 261 260 259 258 257 256 173 Serine/threonine-protein kinase H1
CAMK RPS6KA1-2 KS6A1_HUMAN AF-Q15418-K2A Q15418 410 683 735.0 No_ligand No_ligand Active DFGin 6.642 14.09 BLAminus DFGAsp-rot-in -126.21, 179.26 57.08, 67.05 194.38, 25.63 -75.1, 22.9 287.48, 76.88 -58.82, -29.2 in-in in 8.892 Saltbr-in 2.739 HRD-in -76.33, -42.0 69.77, -2.48 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.48, 128.95 APE9-dihe-na -170.39, 159.86 APE8-dihe-in -93.38, 131.54 APE8-rot-in 299.75 APE67-dihe-in -74.29, -9.58 -51.89, -40.62 APE12-dist-in 8.881 APE11-dist-in 10.755 APE10-dist-in 4.92 APE9-dist-in 4.081 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K2 CAMK_RPS6KA1-2_HUMAN CAMK 6.7e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
CAMK RPS6KA1-2 KS6A1_HUMAN AF-Q15418-K4A Q15418 410 683 735.0 No_ligand No_ligand Active DFGin 6.457 14.262 BLAminus DFGAsp-rot-in -131.98, -176.82 54.0, 62.76 199.02, 14.18 -70.03, 23.23 286.1, 80.23 -67.75, -25.43 in-in in 8.928 Saltbr-in 2.718 HRD-in -78.48, -40.45 68.79, 2.02 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.11, 131.7 APE9-dihe-na -172.39, 156.57 APE8-dihe-in -86.39, 129.69 APE8-rot-in 298.28 APE67-dihe-in -79.01, -8.51 -53.84, -37.0 APE12-dist-in 8.92 APE11-dist-in 10.964 APE10-dist-in 5.083 APE9-dist-in 4.033 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K4 CAMK_RPS6KA1-2_HUMAN CAMK 6.7e-88 300.3 1 256 256 556 557 558 560 562 447 459 463 532 534 533 535 596 584 579 578 577 576 575 574 573 490 Ribosomal protein S6 kinase alpha-1
CAMK RPS6KA2-2 KS6A2_HUMAN AF-Q15349-K2A Q15349 407 680 733.0 No_ligand No_ligand Active DFGin 6.652 14.11 BLAminus DFGAsp-rot-in -125.4, -179.16 57.55, 70.32 195.76, 21.92 -78.41, 25.17 287.92, 78.56 -56.51, -34.86 in-in in 8.845 Saltbr-in 2.745 HRD-in -75.04, -44.25 70.02, -1.4 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.57, 128.45 APE9-dihe-na -171.02, 160.68 APE8-dihe-in -94.96, 132.21 APE8-rot-in 299.43 APE67-dihe-in -73.4, -9.74 -51.26, -43.01 APE12-dist-in 8.74 APE11-dist-in 10.776 APE10-dist-in 4.931 APE9-dist-in 4.118 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K2 CAMK_RPS6KA2-2_HUMAN CAMK 1.2e-87 299.4 1 256 256 553 554 555 557 559 444 456 460 529 531 530 532 593 581 576 575 574 573 572 571 570 487 Ribosomal protein S6 kinase alpha-2
CAMK RPS6KA2-2 KS6A2_HUMAN AF-Q15349-K4A Q15349 407 680 733.0 No_ligand No_ligand Active DFGin 6.328 14.228 BLAminus DFGAsp-rot-in -135.27, -175.54 54.15, 64.63 200.57, 6.48 -71.12, 21.3 285.37, 81.71 -73.26, -23.14 in-in in 8.958 Saltbr-in 2.698 HRD-in -78.2, -43.66 65.94, -8.2 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.63, 122.14 APE9-dihe-na -169.16, 159.04 APE8-dihe-in -89.7, 129.99 APE8-rot-in 297.48 APE67-dihe-in -79.03, -7.61 -53.86, -39.13 APE12-dist-in 9.026 APE11-dist-in 11.333 APE10-dist-in 5.324 APE9-dist-in 4.172 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K4 CAMK_RPS6KA2-2_HUMAN CAMK 1.2e-87 299.4 1 256 256 553 554 555 557 559 444 456 460 529 531 530 532 593 581 576 575 574 573 572 571 570 487 Ribosomal protein S6 kinase alpha-2
CAMK RPS6KA3-2 KS6A3_HUMAN AF-P51812-K2A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.73 14.168 BLAminus DFGAsp-rot-in -125.79, -177.39 55.82, 66.57 196.36, 24.79 -75.99, 24.17 288.05, 79.68 -59.14, -33.85 in-in in 8.837 Saltbr-in 2.739 HRD-in -74.61, -43.89 70.54, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 128.02 APE9-dihe-na -170.43, 160.5 APE8-dihe-in -95.56, 132.02 APE8-rot-in 299.76 APE67-dihe-in -73.03, -14.52 -50.87, -42.54 APE12-dist-in 8.866 APE11-dist-in 10.842 APE10-dist-in 4.993 APE9-dist-in 4.122 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K2 CAMK_RPS6KA3-2_HUMAN CAMK 3.2e-87 298.1 1 256 256 560 561 562 564 566 451 463 467 536 538 537 539 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
CAMK RPS6KA3-2 KS6A3_HUMAN AF-P51812-K4A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.435 14.364 BLAminus DFGAsp-rot-in -132.83, -176.2 53.82, 63.58 198.54, 8.2 -70.94, 24.31 287.91, 81.74 -68.64, -24.12 in-in in 8.914 Saltbr-in 2.751 HRD-in -78.93, -40.76 66.85, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.71, 127.25 APE9-dihe-na -171.64, 159.25 APE8-dihe-in -90.92, 129.8 APE8-rot-in 301.02 APE67-dihe-in -76.65, -14.51 -52.74, -40.79 APE12-dist-in 8.657 APE11-dist-in 10.977 APE10-dist-in 5.071 APE9-dist-in 4.244 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K4 CAMK_RPS6KA3-2_HUMAN CAMK 3.2e-87 298.1 1 256 256 560 561 562 564 566 451 463 467 536 538 537 539 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
CAMK RPS6KA4-2 KS6A4_HUMAN AF-O75676-K2A O75676 400 682 772.0 No_ligand No_ligand Active DFGin 5.625 13.976 BLAminus DFGAsp-rot-in -120.67, 178.37 58.42, 72.08 195.69, 20.67 -82.57, 18.56 283.59, 66.24 -61.05, -28.33 in-in in 8.628 Saltbr-in 2.713 HRD-in -75.59, -46.6 67.67, -1.45 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.5, 118.13 APE9-dihe-na -165.28, 159.12 APE8-dihe-in -96.39, 123.29 APE8-rot-in 303.72 APE67-dihe-in -63.09, -21.71 -49.19, -44.65 APE12-dist-in 8.961 APE11-dist-in 10.83 APE10-dist-in 5.011 APE9-dist-in 4.145 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K2 CAMK_RPS6KA4-2_HUMAN CAMK 1.2e-79 273.2 5 256 252 550 551 552 554 556 440 453 457 527 529 528 530 591 579 574 573 572 571 570 569 568 484 Ribosomal protein S6 kinase alpha-4
CAMK RPS6KA4-2 KS6A4_HUMAN AF-O75676-K4A O75676 400 682 772.0 No_ligand No_ligand Active DFGin 5.176 14.02 BLAminus DFGAsp-rot-in -122.38, 175.76 59.23, 72.02 200.33, 7.65 -80.76, 17.2 284.29, 67.3 -58.65, -30.45 in-in in 8.538 Saltbr-in 2.684 HRD-in -77.81, -45.53 69.45, -2.15 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.24, 117.86 APE9-dihe-na -166.45, 155.97 APE8-dihe-in -91.4, 121.79 APE8-rot-in 302.05 APE67-dihe-in -66.49, -20.11 -51.14, -42.05 APE12-dist-in 8.51 APE11-dist-in 11.128 APE10-dist-in 5.151 APE9-dist-in 4.202 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K4 CAMK_RPS6KA4-2_HUMAN CAMK 1.2e-79 273.2 5 256 252 550 551 552 554 556 440 453 457 527 529 528 530 591 579 574 573 572 571 570 569 568 484 Ribosomal protein S6 kinase alpha-4
CAMK RPS6KA5-2 KS6A5_HUMAN AF-O75582-K2A O75582 415 695 802.0 No_ligand No_ligand Active DFGin 5.603 14.038 BLAminus DFGAsp-rot-in -121.39, 176.9 57.63, 77.29 195.2, 17.7 -87.03, 18.09 283.44, 63.26 -60.04, -29.17 in-in in 8.734 Saltbr-in 2.727 HRD-in -75.89, -46.83 67.59, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.88, 121.73 APE9-dihe-na -165.89, 155.36 APE8-dihe-in -93.68, 121.29 APE8-rot-in 304.68 APE67-dihe-in -64.03, -19.39 -46.88, -48.63 APE12-dist-in 8.826 APE11-dist-in 11.091 APE10-dist-in 5.301 APE9-dist-in 4.395 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K2 CAMK_RPS6KA5-2_HUMAN CAMK 1.3e-87 299.4 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN AF-O75582-K4A O75582 415 695 802.0 No_ligand No_ligand Active DFGin 5.317 14.018 BLAminus DFGAsp-rot-in -120.15, 172.97 56.49, 82.73 198.06, 2.92 -88.05, 15.67 281.76, 63.73 -57.32, -30.97 in-in in 8.535 Saltbr-in 2.657 HRD-in -75.74, -48.78 70.38, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.62, 115.33 APE9-dihe-na -171.98, 154.54 APE8-dihe-in -85.95, 120.48 APE8-rot-in 303.19 APE67-dihe-in -63.89, -23.3 -49.53, -43.21 APE12-dist-in 8.792 APE11-dist-in 11.434 APE10-dist-in 5.793 APE9-dist-in 4.079 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K4 CAMK_RPS6KA5-2_HUMAN CAMK 1.3e-87 299.4 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA6-2 KS6A6_HUMAN AF-Q9UK32-K2A Q9UK32 418 691 745.0 No_ligand No_ligand Active DFGin 6.694 14.12 BLAminus DFGAsp-rot-in -127.11, -179.69 57.75, 68.91 196.45, 21.72 -77.73, 25.98 287.73, 79.4 -59.46, -33.75 in-in in 8.796 Saltbr-in 2.741 HRD-in -76.48, -42.42 69.34, 5.82 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.57, 125.8 APE9-dihe-na -168.54, 160.84 APE8-dihe-in -97.66, 131.38 APE8-rot-in 298.78 APE67-dihe-in -76.51, -14.79 -51.82, -39.1 APE12-dist-in 8.757 APE11-dist-in 10.868 APE10-dist-in 5.026 APE9-dist-in 4.189 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K2 CAMK_RPS6KA6-2_HUMAN CAMK 3.1e-86 294.8 1 256 256 564 565 566 568 570 455 467 471 540 542 541 543 604 592 587 586 585 584 583 582 581 498 Ribosomal protein S6 kinase alpha-6
CAMK RPS6KA6-2 KS6A6_HUMAN AF-Q9UK32-K4A Q9UK32 418 691 745.0 No_ligand No_ligand Active DFGin 6.434 14.218 BLAminus DFGAsp-rot-in -132.15, -176.4 53.04, 63.76 197.99, 9.82 -70.7, 26.81 286.51, 80.64 -68.87, -29.0 in-in in 8.854 Saltbr-in 2.716 HRD-in -78.09, -41.51 66.12, 12.22 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.73, 127.94 APE9-dihe-na -169.87, 160.84 APE8-dihe-in -95.06, 128.48 APE8-rot-in 299.27 APE67-dihe-in -74.76, -17.34 -51.97, -39.65 APE12-dist-in 8.932 APE11-dist-in 11.052 APE10-dist-in 5.212 APE9-dist-in 4.29 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K4 CAMK_RPS6KA6-2_HUMAN CAMK 3.1e-86 294.8 1 256 256 564 565 566 568 570 455 467 471 540 542 541 543 604 592 587 586 585 584 583 582 581 498 Ribosomal protein S6 kinase alpha-6
CAMK SIK1 SIK1_HUMAN AF-P57059-K1A P57059 19 286 783.0 No_ligand No_ligand Active DFGin 6.644 14.938 BLAminus DFGAsp-rot-in -129.98, 172.75 57.65, 79.53 196.72, 11.15 -86.77, 19.59 289.32, 83.62 -59.09, -32.16 in-in in 9.097 Saltbr-in 2.713 HRD-in -80.57, -44.71 62.16, 7.17 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.14, 159.42 APE9-dihe-na 98.85, 173.44 APE8-dihe-in -74.66, 128.69 APE8-rot-in 281.06 APE67-dihe-in -66.51, -19.56 -51.67, -40.03 APE12-dist-in 8.72 APE11-dist-in 10.939 APE10-dist-in 5.209 APE9-dist-in 3.443 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-P57059-K1 CAMK_SIK1_HUMAN CAMK 3.5e-97 330.7 1 256 256 166 167 168 170 172 56 74 78 146 148 147 149 206 193 188 187 186 185 184 183 182 104 Serine/threonine-protein kinase SIK1
CAMK SIK1 SIK1_HUMAN AF-P57059-K3A P57059 19 286 783.0 No_ligand No_ligand Active DFGin 6.192 14.698 BLAminus DFGAsp-rot-in -136.43, 172.4 55.82, 78.83 202.03, -7.03 -81.56, 19.97 292.09, 84.24 -59.67, -26.93 in-in in 8.972 Saltbr-in 2.725 HRD-in -82.42, -43.29 64.43, -1.66 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.48, 172.44 APE9-dihe-na 122.34, 163.62 APE8-dihe-in -75.41, 124.47 APE8-rot-in 299.28 APE67-dihe-in -68.29, -17.77 -51.03, -40.04 APE12-dist-in 8.512 APE11-dist-in 11.128 APE10-dist-in 5.713 APE9-dist-in 3.451 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[27, 278]] 1.0 AF-P57059-K3 CAMK_SIK1_HUMAN CAMK 3.5e-97 330.7 1 256 256 166 167 168 170 172 56 74 78 146 148 147 149 206 193 188 187 186 185 184 183 182 104 Serine/threonine-protein kinase SIK1
CAMK SIK2 SIK2_HUMAN AF-Q9H0K1-K1A Q9H0K1 12 279 926.0 No_ligand No_ligand Active DFGin 6.794 14.904 BLAminus DFGAsp-rot-in -119.71, 175.68 54.99, 79.06 197.01, 11.36 -86.38, 20.59 287.67, 84.31 -58.82, -32.81 in-in in 9.183 Saltbr-in 2.689 HRD-in -84.35, -44.78 62.69, 9.43 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.86, 159.69 APE9-dihe-na 95.61, 178.37 APE8-dihe-in -87.35, 128.5 APE8-rot-in 305.13 APE67-dihe-in -66.65, -20.4 -49.85, -40.76 APE12-dist-in 8.7 APE11-dist-in 10.988 APE10-dist-in 5.221 APE9-dist-in 3.34 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[20, 271]] 1.0 AF-Q9H0K1-K1 CAMK_SIK2_HUMAN CAMK 9.5e-96 326.0 1 256 256 159 160 161 163 165 49 67 71 139 141 140 142 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase SIK2
CAMK SIK2 SIK2_HUMAN AF-Q9H0K1-K3A Q9H0K1 12 279 926.0 No_ligand No_ligand Active DFGin 6.4 14.674 BLAminus DFGAsp-rot-in -127.01, 171.99 54.96, 76.72 202.33, 10.8 -80.3, 21.97 290.31, 82.18 -59.59, -27.04 in-in in 9.123 Saltbr-in 2.733 HRD-in -83.51, -43.49 65.09, -3.92 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.44, 167.61 APE9-dihe-na 125.35, 164.53 APE8-dihe-in -76.88, 124.81 APE8-rot-in 299.49 APE67-dihe-in -67.89, -17.07 -50.55, -40.34 APE12-dist-in 8.33 APE11-dist-in 11.178 APE10-dist-in 5.702 APE9-dist-in 3.527 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[20, 271]] 1.0 AF-Q9H0K1-K3 CAMK_SIK2_HUMAN CAMK 9.5e-96 326.0 1 256 256 159 160 161 163 165 49 67 71 139 141 140 142 199 186 181 180 179 178 177 176 175 97 Serine/threonine-protein kinase SIK2
CAMK SIK3 SIK3_HUMAN AF-Q9Y2K2-K1A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.694 14.451 BLAminus DFGAsp-rot-in -119.54, 177.21 54.68, 82.58 195.32, 13.14 -91.15, 18.08 289.11, 79.8 -61.47, -33.93 in-in in 9.175 Saltbr-in 2.727 HRD-in -84.96, -43.42 62.16, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 160.29 APE9-dihe-na 96.56, 179.01 APE8-dihe-in -86.75, 128.22 APE8-rot-in 305.58 APE67-dihe-in -65.83, -21.44 -50.37, -40.61 APE12-dist-in 8.7 APE11-dist-in 10.887 APE10-dist-in 5.123 APE9-dist-in 3.352 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K1 CAMK_SIK3_HUMAN CAMK 5.9e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SIK3 SIK3_HUMAN AF-Q9Y2K2-K3A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.33 14.41 BLAminus DFGAsp-rot-in -124.8, 175.92 53.15, 79.61 199.83, 3.87 -83.53, 14.89 285.3, 85.28 -59.08, -30.53 in-in in 9.03 Saltbr-in 2.746 HRD-in -84.43, -45.63 65.16, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.55, -178.04 APE9-dihe-na 100.22, 168.15 APE8-dihe-in -79.95, 124.93 APE8-rot-in 300.39 APE67-dihe-in -65.89, -18.74 -51.05, -39.95 APE12-dist-in 8.574 APE11-dist-in 11.03 APE10-dist-in 5.607 APE9-dist-in 3.365 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K3 CAMK_SIK3_HUMAN CAMK 5.9e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
CAMK SNRK SNRK_HUMAN AF-Q9NRH2-K1A Q9NRH2 8 277 765.0 No_ligand No_ligand Active DFGin 6.183 14.55 BLAminus DFGAsp-rot-in -130.35, 176.93 56.3, 74.13 204.55, 24.2 -82.13, 19.15 286.69, 76.59 -61.27, -30.26 in-in in 9.326 Saltbr-in 2.691 HRD-in -77.64, -49.74 63.41, -0.73 in-in-in SNCiii in-in ActLoopNT-in 2.97 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.17, 162.02 APE9-dihe-na 101.61, 175.25 APE8-dihe-in -81.81, 137.31 APE8-rot-in 284.93 APE67-dihe-in -60.81, -21.2 -50.93, -50.39 APE12-dist-in 8.718 APE11-dist-in 11.01 APE10-dist-in 5.26 APE9-dist-in 3.646 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[16, 269]] 1.0 AF-Q9NRH2-K1 CAMK_SNRK_HUMAN CAMK 2e-92 315.1 1 256 256 157 158 159 161 163 45 63 67 136 138 137 139 197 184 179 178 177 176 175 174 173 93 SNF-related serine/threonine-protein kinase
CAMK SNRK SNRK_HUMAN AF-Q9NRH2-K3A Q9NRH2 8 277 765.0 No_ligand No_ligand Active DFGin 5.924 14.309 BLAminus DFGAsp-rot-in -139.66, -179.06 53.22, 71.75 212.2, -34.15 -76.08, 20.11 281.8, 79.34 -56.46, -34.17 in-in in 9.065 Saltbr-in 2.733 HRD-in -81.42, -50.8 63.56, -2.54 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.65, -177.08 APE9-dihe-na 80.73, -173.0 APE8-dihe-in -110.34, 138.2 APE8-rot-in 320.64 APE67-dihe-in -62.81, -17.25 -44.08, -54.61 APE12-dist-in 8.117 APE11-dist-in 11.003 APE10-dist-in 5.505 APE9-dist-in 3.685 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[16, 269]] 1.0 AF-Q9NRH2-K3 CAMK_SNRK_HUMAN CAMK 2e-92 315.1 1 256 256 157 158 159 161 163 45 63 67 136 138 137 139 197 184 179 178 177 176 175 174 173 93 SNF-related serine/threonine-protein kinase
CAMK SPEG-1 SPEG_HUMAN AF-Q15772-K1A Q15772 1593 1862 3267.0 No_ligand No_ligand Active DFGin 6.294 13.96 BLAminus DFGAsp-rot-in -127.06, 179.84 59.04, 70.5 200.98, 8.33 -74.62, 23.83 289.34, 79.26 -62.39, -36.22 in-in in 8.864 Saltbr-in 2.689 HRD-in -76.67, -48.12 61.39, 9.36 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.52, 159.43 APE9-dihe-na 138.1, 163.86 APE8-dihe-in -77.9, 127.8 APE8-rot-in 300.42 APE67-dihe-in -66.06, -31.59 -49.49, -33.98 APE12-dist-in 7.655 APE11-dist-in 10.264 APE10-dist-in 5.929 APE9-dist-in 4.941 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[1601, 1854], [2966, 3218]] 2.0 AF-Q15772-K1 CAMK_SPEG-1_HUMAN CAMK 3.7e-71 245.4 1 256 256 1740 1741 1742 1744 1746 1630 1645 1649 1716 1718 1717 1719 1779 1767 1762 1761 1760 1759 1758 1757 1756 1675 Striated muscle preferentially expressed protein kinase
CAMK SPEG-1 SPEG_HUMAN AF-Q15772-K3A Q15772 1593 1862 3267.0 No_ligand No_ligand Active DFGin 5.945 13.927 BLAminus DFGAsp-rot-in -132.67, 178.96 54.48, 77.64 206.6, -23.59 -79.6, 26.95 292.13, 81.5 -64.78, -33.5 in-in in 8.774 Saltbr-in 2.728 HRD-in -79.85, -47.44 63.34, 8.04 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.27, 157.12 APE9-dihe-na 164.99, 164.51 APE8-dihe-in -82.03, 129.08 APE8-rot-in 297.68 APE67-dihe-in -77.06, -28.74 -51.78, -32.89 APE12-dist-in 7.252 APE11-dist-in 9.665 APE10-dist-in 6.296 APE9-dist-in 4.834 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[1601, 1854], [2966, 3218]] 2.0 AF-Q15772-K3 CAMK_SPEG-1_HUMAN CAMK 3.7e-71 245.4 1 256 256 1740 1741 1742 1744 1746 1630 1645 1649 1716 1718 1717 1719 1779 1767 1762 1761 1760 1759 1758 1757 1756 1675 Striated muscle preferentially expressed protein kinase
CAMK SPEG-2 SPEG_HUMAN AF-Q15772-K2A Q15772 2958 3226 3267.0 No_ligand No_ligand Active DFGin 6.704 13.53 BLAminus DFGAsp-rot-in -123.37, 171.71 58.4, 85.56 196.87, -5.84 -91.05, 20.13 285.74, 77.72 -64.09, -25.88 in-in in 8.189 Saltbr-in 2.66 HRD-in -81.22, -44.79 65.23, 4.7 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.62, 170.75 APE9-dihe-na 75.36, -171.05 APE8-dihe-in -95.47, 124.93 APE8-rot-in 296.37 APE67-dihe-in -55.39, -27.99 -51.12, -47.01 APE12-dist-in 10.321 APE11-dist-in 10.889 APE10-dist-in 5.014 APE9-dist-in 4.253 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[1601, 1854], [2966, 3218]] 2.0 AF-Q15772-K2 CAMK_SPEG-2_HUMAN CAMK 3.5e-70 242.2 1 256 256 3102 3103 3104 3106 3108 2995 3010 3014 3082 3084 3083 3085 3143 3131 3126 3125 3124 3123 3122 3121 3120 3040 Striated muscle preferentially expressed protein kinase
CAMK SPEG-2 SPEG_HUMAN AF-Q15772-K4A Q15772 2958 3226 3267.0 No_ligand No_ligand Active DFGin 6.464 13.572 BLAminus DFGAsp-rot-in -129.62, 174.0 53.57, 88.0 198.69, -12.91 -90.65, 18.21 285.96, 79.38 -63.76, -19.69 in-in in 8.119 Saltbr-in 2.696 HRD-in -83.33, -44.04 65.09, 7.54 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 165.73 APE9-dihe-na 72.61, -163.33 APE8-dihe-in -108.75, 125.58 APE8-rot-in 309.64 APE67-dihe-in -56.2, -27.05 -49.46, -48.42 APE12-dist-in 10.218 APE11-dist-in 10.372 APE10-dist-in 4.707 APE9-dist-in 3.601 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[1601, 1854], [2966, 3218]] 2.0 AF-Q15772-K4 CAMK_SPEG-2_HUMAN CAMK 3.5e-70 242.2 1 256 256 3102 3103 3104 3106 3108 2995 3010 3014 3082 3084 3083 3085 3143 3131 3126 3125 3124 3123 3122 3121 3120 3040 Striated muscle preferentially expressed protein kinase
CAMK STK11 STK11_HUMAN AF-Q15831-K1A Q15831 41 317 433.0 No_ligand No_ligand Active DFGin 6.287 13.779 BLAminus DFGAsp-rot-in -127.61, 171.6 61.48, 66.66 204.4, 20.69 -78.64, 20.71 299.0, 175.52 -59.52, -33.69 in-in in 9.215 Saltbr-in 2.858 HRD-in -73.94, -42.57 67.07, -5.87 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 64.86, -2.19 APE9-dihe-na -78.19, -179.82 APE8-dihe-in -70.83, 127.95 APE8-rot-in 301.52 APE67-dihe-in -66.59, -14.55 -52.1, -47.62 APE12-dist-in 7.844 APE11-dist-in 9.456 APE10-dist-in 5.332 APE9-dist-in 3.377 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[49, 309]] 1.0 AF-Q15831-K1 CAMK_STK11_HUMAN CAMK 2.1e-67 233.1 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN AF-Q15831-K3A Q15831 41 317 433.0 No_ligand No_ligand Active DFGin 6.417 13.815 BLAminus DFGAsp-rot-in -134.05, 177.14 56.13, 60.42 208.29, 15.69 -74.08, 25.29 292.64, 80.14 -65.28, -27.35 in-in in 9.148 Saltbr-in 2.891 HRD-in -82.09, -39.4 66.99, -13.94 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.42, 123.18 APE9-dihe-na 160.86, -177.9 APE8-dihe-in -77.53, 127.56 APE8-rot-in 304.86 APE67-dihe-in -65.01, -14.14 -50.91, -44.7 APE12-dist-in 8.691 APE11-dist-in 10.153 APE10-dist-in 4.855 APE9-dist-in 3.828 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[49, 309]] 1.0 AF-Q15831-K3 CAMK_STK11_HUMAN CAMK 2.1e-67 233.1 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK17A ST17A_HUMAN AF-Q9UEE5-K1A Q9UEE5 51 329 414.0 No_ligand No_ligand Active DFGin 6.159 14.099 BLAminus DFGAsp-rot-in -129.27, 170.92 64.97, 64.55 204.3, 19.65 -75.43, 21.24 291.56, 83.12 -65.43, -24.67 in-in in 9.002 Saltbr-in 2.633 HRD-in -80.88, -43.24 65.02, -3.61 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.49, 177.42 APE9-dihe-na 89.95, -178.48 APE8-dihe-in -91.88, 126.45 APE8-rot-in 302.18 APE67-dihe-in -76.05, -22.22 -46.99, -32.12 APE12-dist-in 9.005 APE11-dist-in 12.14 APE10-dist-in 6.485 APE9-dist-in 4.683 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[59, 321]] 1.0 AF-Q9UEE5-K1 CAMK_STK17A_HUMAN CAMK 1.4e-86 295.9 4 256 253 206 207 208 210 212 90 108 112 183 185 184 186 245 233 228 227 226 225 224 223 222 139 Serine/threonine-protein kinase 17A
CAMK STK17A ST17A_HUMAN AF-Q9UEE5-K3A Q9UEE5 51 329 414.0 No_ligand No_ligand Active DFGin 5.918 13.901 BLAminus DFGAsp-rot-in -132.98, 171.56 63.24, 63.04 203.46, 18.14 -72.48, 15.51 295.77, 90.58 -64.92, -20.79 in-in in 8.778 Saltbr-in 2.595 HRD-in -84.59, -41.6 65.53, 5.87 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.79, -176.51 APE9-dihe-na 92.4, 171.63 APE8-dihe-in -81.96, 126.41 APE8-rot-in 298.66 APE67-dihe-in -72.42, -21.04 -47.99, -41.58 APE12-dist-in 8.97 APE11-dist-in 12.044 APE10-dist-in 6.293 APE9-dist-in 3.632 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[59, 321]] 1.0 AF-Q9UEE5-K3 CAMK_STK17A_HUMAN CAMK 1.4e-86 295.9 4 256 253 206 207 208 210 212 90 108 112 183 185 184 186 245 233 228 227 226 225 224 223 222 139 Serine/threonine-protein kinase 17A
CAMK STK17B ST17B_HUMAN AF-O94768-K1A O94768 24 301 372.0 No_ligand No_ligand Active DFGin 6.378 13.949 BLAminus DFGAsp-rot-in -131.71, 171.68 62.89, 65.23 204.6, 13.71 -80.16, 15.72 294.95, 92.5 -61.68, -26.23 in-in in 8.962 Saltbr-in 2.61 HRD-in -74.35, -40.86 62.28, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.39, 141.06 APE9-dihe-na 119.08, -176.45 APE8-dihe-in -92.52, 130.0 APE8-rot-in 304.62 APE67-dihe-in -68.33, -14.1 -46.02, -52.27 APE12-dist-in 11.032 APE11-dist-in 12.098 APE10-dist-in 6.209 APE9-dist-in 3.858 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[32, 293]] 1.0 AF-O94768-K1 CAMK_STK17B_HUMAN CAMK 7.7e-82 280.4 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN AF-O94768-K3A O94768 24 301 372.0 No_ligand No_ligand Active DFGin 6.035 13.873 BLAminus DFGAsp-rot-in -132.35, 170.87 64.06, 64.13 207.09, 7.66 -75.86, 13.09 295.78, 93.11 -63.33, -22.21 in-in in 8.846 Saltbr-in 2.6 HRD-in -81.95, -40.82 66.69, -5.34 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.99, 150.93 APE9-dihe-na 129.29, -168.24 APE8-dihe-in -96.41, 129.1 APE8-rot-in 303.67 APE67-dihe-in -68.22, -14.61 -46.81, -49.64 APE12-dist-in 9.258 APE11-dist-in 12.412 APE10-dist-in 6.711 APE9-dist-in 4.171 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[32, 293]] 1.0 AF-O94768-K3 CAMK_STK17B_HUMAN CAMK 7.7e-82 280.4 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK33 STK33_HUMAN AF-Q9BYT3-K1A Q9BYT3 108 389 514.0 No_ligand No_ligand Active DFGin 6.66 14.705 BLAminus DFGAsp-rot-in -130.31, 179.43 56.8, 69.41 197.09, 15.46 -81.35, 16.51 288.19, 79.43 -59.85, -34.33 in-in in 9.231 Saltbr-in 2.738 HRD-in -74.34, -48.53 68.06, -1.62 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.25, 168.65 APE9-dihe-na 112.06, 176.83 APE8-dihe-in -89.55, 127.36 APE8-rot-in 303.28 APE67-dihe-in -68.04, -19.93 -47.34, -44.59 APE12-dist-in 9.102 APE11-dist-in 11.847 APE10-dist-in 6.186 APE9-dist-in 3.619 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[116, 381]] 1.0 AF-Q9BYT3-K1 CAMK_STK33_HUMAN CAMK 1.4e-86 296.0 1 256 256 264 265 266 268 270 145 163 167 235 237 236 238 305 293 288 287 286 285 284 283 282 193 Serine/threonine-protein kinase 33
CAMK STK33 STK33_HUMAN AF-Q9BYT3-K3A Q9BYT3 108 389 514.0 No_ligand No_ligand Active DFGin 6.271 14.863 BLAminus DFGAsp-rot-in -137.14, -177.35 56.52, 70.74 198.5, -7.99 -80.95, 17.63 294.69, 85.92 -61.28, -33.43 in-in in 9.18 Saltbr-in 2.816 HRD-in -79.8, -46.24 68.64, -4.2 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.37, 162.39 APE9-dihe-na 117.13, -169.04 APE8-dihe-in -99.87, 122.21 APE8-rot-in 302.77 APE67-dihe-in -64.14, -28.71 -44.57, -44.59 APE12-dist-in 8.787 APE11-dist-in 11.812 APE10-dist-in 6.102 APE9-dist-in 3.482 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[116, 381]] 1.0 AF-Q9BYT3-K3 CAMK_STK33_HUMAN CAMK 1.4e-86 296.0 1 256 256 264 265 266 268 270 145 163 167 235 237 236 238 305 293 288 287 286 285 284 283 282 193 Serine/threonine-protein kinase 33
CAMK TRIO TRIO_HUMAN AF-O75962-K1A O75962 2788 3058 3097.0 No_ligand No_ligand Active DFGin 6.762 13.703 BLAminus DFGAsp-rot-in -132.92, 169.58 60.79, 76.7 204.65, 8.87 -85.5, 21.19 291.26, 83.37 -61.0, -31.51 in-in in 9.0 Saltbr-in 2.722 HRD-in -79.13, -38.91 61.97, 2.6 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -94.32, 137.85 APE9-dihe-na 73.6, -164.16 APE8-dihe-in -79.61, 118.02 APE8-rot-na 177.66 APE67-dihe-in -52.64, -35.17 -56.72, -28.91 APE12-dist-in 12.531 APE11-dist-in 11.747 APE10-dist-in 5.747 APE9-dist-in 5.868 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[2796, 3050]] 1.0 AF-O75962-K1 CAMK_TRIO_HUMAN CAMK 4.2e-77 264.9 1 256 256 2935 2936 2937 2939 2941 2825 2840 2844 2912 2914 2913 2915 2974 2962 2957 2956 2955 2954 2953 2952 2951 2870 Triple functional domain protein
CAMK TRIO TRIO_HUMAN AF-O75962-K3A O75962 2788 3058 3097.0 No_ligand No_ligand Active DFGin 6.516 13.674 BLAminus DFGAsp-rot-in -137.07, 173.81 59.14, 65.73 210.96, 9.13 -77.6, 21.57 297.0, 87.18 -63.24, -34.6 in-in in 8.999 Saltbr-in 2.725 HRD-in -84.11, -37.89 63.98, -10.1 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -113.5, -21.95 APE9-dihe-na -84.15, -159.19 APE8-dihe-in -84.08, 118.6 APE8-rot-na 186.64 APE67-dihe-in -53.65, -37.18 -59.47, -28.79 APE12-dist-in 8.939 APE11-dist-in 10.395 APE10-dist-in 6.655 APE9-dist-in 5.988 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[2796, 3050]] 1.0 AF-O75962-K3 CAMK_TRIO_HUMAN CAMK 4.2e-77 264.9 1 256 256 2935 2936 2937 2939 2941 2825 2840 2844 2912 2914 2913 2915 2974 2962 2957 2956 2955 2954 2953 2952 2951 2870 Triple functional domain protein
CAMK TSSK1B TSSK1_HUMAN AF-Q9BXA7-K1A Q9BXA7 4 280 367.0 No_ligand No_ligand Active DFGin 7.185 14.325 BLAminus DFGAsp-rot-in -137.21, 172.4 58.68, 77.48 196.52, 17.79 -86.34, 21.42 289.14, 78.32 -63.02, -33.78 in-in in 9.492 Saltbr-in 2.656 HRD-in -85.59, -47.69 63.44, 5.79 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, 170.45 APE9-dihe-na 103.17, 175.22 APE8-dihe-in -77.99, 125.19 APE8-rot-in 304.96 APE67-dihe-in -63.77, -25.39 -54.08, -36.59 APE12-dist-in 8.575 APE11-dist-in 11.468 APE10-dist-in 5.803 APE9-dist-in 3.569 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[12, 272]] 1.0 AF-Q9BXA7-K1 CAMK_TSSK1B_HUMAN CAMK 6.2e-84 287.3 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 198 185 180 179 178 177 176 175 174 91 Testis-specific serine/threonine-protein kinase 1
CAMK TSSK1B TSSK1_HUMAN AF-Q9BXA7-K3A Q9BXA7 4 280 367.0 No_ligand No_ligand Active DFGin 6.894 14.168 BLAminus DFGAsp-rot-in -140.76, 178.47 56.64, 67.24 197.4, 12.51 -75.14, 18.42 288.68, 87.34 -58.72, -33.18 in-in in 9.3 Saltbr-in 2.629 HRD-in -85.88, -50.73 66.28, 7.75 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.12, 171.63 APE9-dihe-na 104.63, 172.88 APE8-dihe-in -80.84, 122.77 APE8-rot-in 299.99 APE67-dihe-in -67.42, -19.4 -53.9, -38.81 APE12-dist-in 8.37 APE11-dist-in 11.468 APE10-dist-in 5.877 APE9-dist-in 3.337 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[12, 272]] 1.0 AF-Q9BXA7-K3 CAMK_TSSK1B_HUMAN CAMK 6.2e-84 287.3 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 198 185 180 179 178 177 176 175 174 91 Testis-specific serine/threonine-protein kinase 1
CAMK TSSK2 TSSK2_HUMAN AF-Q96PF2-K1A Q96PF2 4 280 358.0 No_ligand No_ligand Active DFGin 6.997 14.557 BLAminus DFGAsp-rot-in -136.83, 173.17 58.45, 75.36 200.59, 26.66 -81.0, 17.78 282.44, 77.84 -59.06, -35.51 in-in in 9.584 Saltbr-in 2.67 HRD-in -84.32, -46.74 64.45, 2.51 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 171.26 APE9-dihe-na 99.82, 177.21 APE8-dihe-in -81.48, 127.42 APE8-rot-in 306.86 APE67-dihe-in -62.29, -25.34 -55.94, -37.94 APE12-dist-in 8.7 APE11-dist-in 11.52 APE10-dist-in 5.928 APE9-dist-in 3.544 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[12, 272]] 1.0 AF-Q96PF2-K1 CAMK_TSSK2_HUMAN CAMK 1.5e-83 286.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 198 185 180 179 178 177 176 175 174 91 Testis-specific serine/threonine-protein kinase 2
CAMK TSSK2 TSSK2_HUMAN AF-Q96PF2-K3A Q96PF2 4 280 358.0 No_ligand No_ligand Active DFGin 6.642 14.18 BLAminus DFGAsp-rot-in -139.24, 177.65 55.35, 69.68 205.04, 11.83 -74.13, 19.12 290.7, 81.08 -62.24, -26.73 in-in in 9.54 Saltbr-in 2.649 HRD-in -85.9, -49.9 64.51, 14.89 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.62, 174.66 APE9-dihe-na 100.36, 176.88 APE8-dihe-in -89.42, 129.25 APE8-rot-in 306.13 APE67-dihe-in -59.99, -22.19 -57.11, -42.0 APE12-dist-in 8.395 APE11-dist-in 11.3 APE10-dist-in 5.751 APE9-dist-in 3.451 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[12, 272]] 1.0 AF-Q96PF2-K3 CAMK_TSSK2_HUMAN CAMK 1.5e-83 286.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 198 185 180 179 178 177 176 175 174 91 Testis-specific serine/threonine-protein kinase 2
CAMK TSSK3 TSSK3_HUMAN AF-Q96PN8-K1A Q96PN8 2 268 268.0 No_ligand No_ligand Active DFGin 6.698 14.086 BLAminus DFGAsp-rot-in -137.16, 175.65 60.55, 76.87 200.85, 11.18 -87.84, 22.34 291.09, 79.71 -59.3, -28.51 in-in in 9.646 Saltbr-in 2.735 HRD-in -78.06, -46.69 65.94, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.81, 140.14 APE9-dihe-na 107.5, -173.06 APE8-dihe-in -92.66, 127.32 APE8-rot-in 308.43 APE67-dihe-in -57.24, -26.97 -49.95, -48.34 APE12-dist-in 9.257 APE11-dist-in 11.04 APE10-dist-in 5.199 APE9-dist-in 3.728 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[10, 265]] 1.0 AF-Q96PN8-K1 CAMK_TSSK3_HUMAN CAMK 7.8e-80 273.8 1 256 256 150 151 152 154 156 39 58 62 131 133 132 134 192 179 174 173 172 171 170 169 168 89 Testis-specific serine/threonine-protein kinase 3
CAMK TSSK3 TSSK3_HUMAN AF-Q96PN8-K3A Q96PN8 2 268 268.0 No_ligand No_ligand Active DFGin 6.43 14.325 BLAminus DFGAsp-rot-in -140.42, 178.49 57.76, 71.41 200.67, 12.7 -80.3, 21.05 290.8, 82.68 -56.65, -36.67 in-in in 9.597 Saltbr-in 2.756 HRD-in -82.64, -44.84 64.05, 13.45 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.42, 168.66 APE9-dihe-na 110.02, 171.4 APE8-dihe-in -79.7, 123.78 APE8-rot-in 301.93 APE67-dihe-in -57.42, -23.21 -49.28, -48.92 APE12-dist-in 8.423 APE11-dist-in 11.277 APE10-dist-in 5.68 APE9-dist-in 3.242 None None None AF2 -1.0 1.0 1.0 A 267 267 0 0 0 0 [[10, 265]] 1.0 AF-Q96PN8-K3 CAMK_TSSK3_HUMAN CAMK 7.8e-80 273.8 1 256 256 150 151 152 154 156 39 58 62 131 133 132 134 192 179 174 173 172 171 170 169 168 89 Testis-specific serine/threonine-protein kinase 3
CAMK TSSK4 TSSK4_HUMAN AF-Q6SA08-K1A Q6SA08 17 301 328.0 No_ligand No_ligand Active DFGin 6.416 13.936 BLAminus DFGAsp-rot-in -128.54, 176.82 54.53, 79.32 201.8, -2.99 -85.8, 19.41 300.04, 97.32 -58.91, -29.61 in-in in 9.748 Saltbr-in 2.796 HRD-in -83.06, -49.77 66.34, 13.83 in-in-in SNCiii in-in ActLoopNT-in 3.004 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.44, 168.04 APE9-dihe-na 96.56, 173.24 APE8-dihe-in -71.43, 124.21 APE8-rot-in 280.79 APE67-dihe-in -57.64, -26.71 -57.13, -38.77 APE12-dist-in 8.934 APE11-dist-in 11.599 APE10-dist-in 5.946 APE9-dist-in 3.639 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[25, 293]] 1.0 AF-Q6SA08-K1 CAMK_TSSK4_HUMAN CAMK 2.5e-72 249.6 1 256 256 165 166 167 169 171 54 73 77 145 147 146 148 221 208 203 202 201 200 199 198 197 103 Testis-specific serine/threonine-protein kinase 4
CAMK TSSK4 TSSK4_HUMAN AF-Q6SA08-K3A Q6SA08 17 301 328.0 No_ligand No_ligand Active DFGin 6.165 14.208 BLAminus DFGAsp-rot-in -135.74, 179.28 48.73, 81.11 208.23, -33.06 -83.19, 18.57 296.51, 96.41 -56.93, -31.31 in-in in 9.588 Saltbr-in 2.839 HRD-in -84.52, -49.7 66.34, 5.45 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.74, 170.41 APE9-dihe-na 95.06, 171.39 APE8-dihe-in -81.03, 122.91 APE8-rot-in 303.61 APE67-dihe-in -55.04, -26.39 -57.26, -38.7 APE12-dist-in 8.653 APE11-dist-in 11.28 APE10-dist-in 5.699 APE9-dist-in 3.366 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[25, 293]] 1.0 AF-Q6SA08-K3 CAMK_TSSK4_HUMAN CAMK 2.5e-72 249.6 1 256 256 165 166 167 169 171 54 73 77 145 147 146 148 221 208 203 202 201 200 199 198 197 103 Testis-specific serine/threonine-protein kinase 4
CAMK TSSK6 TSSK6_HUMAN AF-Q9BXA6-K1A Q9BXA6 4 273 273.0 No_ligand No_ligand Active DFGin 6.875 13.889 BLAminus DFGAsp-rot-in -135.32, 174.48 58.04, 78.01 202.3, 5.11 -87.68, 25.53 294.97, 86.86 -58.46, -26.47 in-in in 9.485 Saltbr-in 2.689 HRD-in -89.42, -48.66 61.95, 15.63 in-in-in SNCiii in-in ActLoopNT-in 3.001 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.57, 168.92 APE9-dihe-na 99.71, 178.11 APE8-dihe-in -80.99, 124.72 APE8-rot-in 305.68 APE67-dihe-in -63.51, -23.98 -56.48, -38.19 APE12-dist-in 8.687 APE11-dist-in 11.304 APE10-dist-in 5.753 APE9-dist-in 3.5 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[12, 267]] 1.0 AF-Q9BXA6-K1 CAMK_TSSK6_HUMAN CAMK 6.2e-73 251.2 1 256 256 153 154 155 157 159 41 60 64 132 134 133 135 194 181 176 175 174 173 172 171 170 91 Testis-specific serine/threonine-protein kinase 6
CAMK TSSK6 TSSK6_HUMAN AF-Q9BXA6-K3A Q9BXA6 4 273 273.0 No_ligand No_ligand Active DFGin 6.713 13.97 BLAminus DFGAsp-rot-in -142.02, 177.23 57.03, 67.8 204.99, 8.22 -79.26, 26.94 296.87, 91.36 -59.06, -31.4 in-in in 9.417 Saltbr-in 2.694 HRD-in -89.49, -49.99 60.62, 19.58 in-in-in SNCiii in-in ActLoopNT-in 3.058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.88, 170.6 APE9-dihe-na 104.87, 178.6 APE8-dihe-in -83.99, 122.22 APE8-rot-in 303.43 APE67-dihe-in -62.9, -22.5 -58.25, -37.83 APE12-dist-in 8.224 APE11-dist-in 11.268 APE10-dist-in 5.754 APE9-dist-in 3.428 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[12, 267]] 1.0 AF-Q9BXA6-K3 CAMK_TSSK6_HUMAN CAMK 6.2e-73 251.2 1 256 256 153 154 155 157 159 41 60 64 132 134 133 135 194 181 176 175 174 173 172 171 170 91 Testis-specific serine/threonine-protein kinase 6
CK1 CSNK1A1 KC1A_HUMAN AF-P48729-K1A P48729 9 291 337.0 No_ligand No_ligand Active DFGin 6.564 14.609 BLAminus DFGAsp-rot-in -131.89, 178.07 63.83, 65.03 201.17, 24.75 -83.92, 12.5 294.04, 95.5 -60.73, -24.65 in-in in 8.021 Saltbr-in 2.687 HRD-in -78.3, -43.51 64.68, 6.22 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.38, 135.89 APE9-dihe-na 97.47, -177.39 APE8-dihe-in -78.29, 109.51 APE8-rot-in 300.56 APE67-dihe-in -57.65, -41.12 -48.47, -33.48 APE12-dist-in 12.229 APE11-dist-in 12.405 APE10-dist-in 6.785 APE9-dist-in 3.392 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[17, 283]] 1.0 AF-P48729-K1 CK1_CSNK1A1_HUMAN CK1 1.4e-121 410.8 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1A1 KC1A_HUMAN AF-P48729-K3A P48729 9 291 337.0 No_ligand No_ligand Active DFGin 6.689 14.729 BLAminus DFGAsp-rot-in -135.46, -177.92 66.55, 52.14 199.73, 26.18 -77.01, 10.21 297.91, 102.31 -60.85, -23.82 in-in in 8.078 Saltbr-in 2.725 HRD-in -80.68, -43.39 66.41, 6.55 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.73, 137.95 APE9-dihe-na 92.53, -176.06 APE8-dihe-in -78.26, 109.56 APE8-rot-in 298.23 APE67-dihe-in -57.65, -40.16 -46.1, -34.86 APE12-dist-in 12.171 APE11-dist-in 12.284 APE10-dist-in 6.784 APE9-dist-in 3.212 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[17, 283]] 1.0 AF-P48729-K3 CK1_CSNK1A1_HUMAN CK1 1.4e-121 410.8 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1A1 KC1A_HUMAN 6GZDA P48729 9 305 337.0 LCI:1018 Type1 Active DFGin 6.702 14.844 BLAminus DFGAsp-rot-in -131.55, 177.32 70.46, 86.44 203.03, -16.51 -102.55, 22.91 293.61, 98.06 -62.66, -35.34 in-in in 8.096 Saltbr-in 3.131 HRD-in -82.14, -48.34 69.83, 12.74 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.35, -32.42 APE9-dihe-na -87.44, -150.21 APE8-dihe-in -91.1, 131.82 APE8-rot-in 300.27 APE67-dihe-in -60.82, -38.86 -68.26, -34.55 APE12-dist-in 11.658 APE11-dist-in 11.949 APE10-dist-in 6.279 APE9-dist-in 3.639 None None None XRAY 2.28 0.177 0.221 A 374 297 0 0 0 0 [[17, 283]] 1.0 6gzd CK1_CSNK1A1_HUMAN CK1 6.4e-122 412.0 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1A1L KC1AL_HUMAN AF-Q8N752-K1A Q8N752 9 291 337.0 No_ligand No_ligand Active DFGin 6.644 14.492 BLAminus DFGAsp-rot-in -133.47, 177.03 64.88, 64.14 202.01, 27.13 -82.9, 12.59 298.3, 98.49 -61.42, -22.98 in-in in 8.059 Saltbr-in 2.683 HRD-in -78.31, -45.78 63.53, 5.11 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.85, 140.44 APE9-dihe-na 95.61, -178.0 APE8-dihe-in -76.54, 108.76 APE8-rot-in 299.99 APE67-dihe-in -57.47, -39.36 -49.57, -34.01 APE12-dist-in 12.27 APE11-dist-in 12.496 APE10-dist-in 6.792 APE9-dist-in 3.468 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[17, 283]] 1.0 AF-Q8N752-K1 CK1_CSNK1A1L_HUMAN CK1 4.9e-118 399.2 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha-like
CK1 CSNK1A1L KC1AL_HUMAN AF-Q8N752-K3A Q8N752 9 291 337.0 No_ligand No_ligand Active DFGin 6.719 14.714 BLAminus DFGAsp-rot-in -135.15, -177.01 66.35, 56.66 192.38, 18.29 -81.49, 9.85 297.89, 103.87 -60.13, -24.54 in-in in 7.929 Saltbr-in 2.68 HRD-in -79.57, -46.3 66.26, -8.08 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.35, 144.02 APE9-dihe-na 88.42, -174.53 APE8-dihe-in -76.72, 108.53 APE8-rot-in 295.41 APE67-dihe-in -59.93, -38.12 -44.07, -36.46 APE12-dist-in 12.198 APE11-dist-in 12.342 APE10-dist-in 6.755 APE9-dist-in 3.344 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[17, 283]] 1.0 AF-Q8N752-K3 CK1_CSNK1A1L_HUMAN CK1 4.9e-118 399.2 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha-like
CK1 CSNK1D KC1D_HUMAN 6RU6A P48730 3 294 415.0 ACP:60301 ATPlike Active DFGin 6.436 15.264 BLAminus DFGAsp-rot-in -136.56, 176.84 69.53, 73.53 194.2, 15.06 -93.66, 24.95 289.84, 81.36 -61.77, -30.96 in-in in 7.923 Saltbr-in 2.789 HRD-in -77.83, -55.12 76.08, 12.52 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.64, 119.59 APE9-dihe-na 102.6, -136.74 APE8-dihe-in -117.46, 127.27 APE8-rot-in 311.09 APE67-dihe-in -57.82, -37.85 -53.66, -47.41 APE12-dist-in 12.315 APE11-dist-in 11.908 APE10-dist-in 6.481 APE9-dist-in 3.505 None None None XRAY 2.05 0.213 0.257 A 296 288 4 0 0 0 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FA P48730 3 294 415.0 AMP:305 ATPlike Active DFGin 6.386 14.989 BLAminus DFGAsp-rot-in -135.41, 179.24 65.29, 82.6 205.96, -24.06 -99.51, 20.86 287.48, 77.77 -56.63, -36.85 in-in in 8.099 Saltbr-in 2.591 HRD-in -82.17, -51.93 74.76, 11.47 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.01, 118.96 APE9-dihe-na 109.81, -163.5 APE8-dihe-in -91.97, 119.49 APE8-rot-in 320.94 APE67-dihe-in -55.9, -38.32 -51.55, -37.41 APE12-dist-in 13.114 APE11-dist-in 12.585 APE10-dist-in 6.845 APE9-dist-in 3.948 None TPO220 TPO220 XRAY 1.96 0.19 0.221 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FB P48730 3 294 415.0 AMP:310 ATPlike Active DFGin 6.389 15.041 BLAminus DFGAsp-rot-in -134.9, -178.65 62.6, 84.78 199.77, -13.05 -99.93, 21.19 288.23, 78.97 -57.89, -34.16 in-in in 8.117 Saltbr-in 2.593 HRD-in -86.23, -54.05 76.65, 11.34 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.84, 118.88 APE9-dihe-na 108.83, -162.51 APE8-dihe-in -93.95, 118.29 APE8-rot-in 320.41 APE67-dihe-in -55.93, -38.53 -50.49, -37.42 APE12-dist-in 13.14 APE11-dist-in 12.546 APE10-dist-in 6.804 APE9-dist-in 4.014 None TPO220 TPO220 XRAY 1.96 0.19 0.221 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HA P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.85 14.904 BLAminus DFGAsp-rot-in -131.69, 175.32 69.71, 86.46 190.35, -19.01 -98.17, 29.2 291.07, 84.43 -61.3, -36.51 in-in in 8.328 Saltbr-in 2.869 HRD-in -85.02, -56.99 74.97, 14.35 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.26, -19.24 APE9-dihe-na -88.34, -159.24 APE8-dihe-in -92.63, 127.36 APE8-rot-in 313.8 APE67-dihe-in -57.88, -32.21 -74.29, -29.96 APE12-dist-in 10.816 APE11-dist-in 12.399 APE10-dist-in 6.988 APE9-dist-in 4.101 None None None XRAY 2.4 0.225 0.268 A 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7HB P48730 3 294 415.0 AMP:301 ATPlike Active DFGin 5.843 14.916 BLAminus DFGAsp-rot-in -130.5, 174.9 69.57, 86.72 184.26, 8.49 -100.58, 28.91 292.34, 82.14 -57.01, -35.01 in-in in 8.325 Saltbr-in 2.918 HRD-in -84.55, -57.9 81.6, 9.08 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.93, 49.41 APE9-dihe-na 140.08, -131.01 APE8-dihe-in -99.84, 119.2 APE8-rot-in 321.52 APE67-dihe-in -56.55, -33.9 -75.78, -27.7 APE12-dist-in 12.421 APE11-dist-in 12.165 APE10-dist-in 7.215 APE9-dist-in 4.736 None None None XRAY 2.4 0.225 0.268 B 296 292 0 0 0 0 [[9, 275]] 1.0 7p7h CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN AF-P48730-K1A P48730 1 283 415.0 No_ligand No_ligand Active DFGin 6.014 14.738 BLAminus DFGAsp-rot-in -133.52, 176.85 64.1, 66.27 202.53, 22.24 -77.63, 11.73 293.67, 97.86 -60.56, -26.09 in-in in 8.117 Saltbr-in 2.685 HRD-in -76.86, -43.78 66.27, -7.2 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.58, 134.54 APE9-dihe-na 97.48, -176.89 APE8-dihe-in -80.26, 109.12 APE8-rot-in 301.44 APE67-dihe-in -58.05, -41.24 -50.16, -30.35 APE12-dist-in 12.286 APE11-dist-in 12.4 APE10-dist-in 6.762 APE9-dist-in 3.559 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[9, 275]] 1.0 AF-P48730-K1 CK1_CSNK1D_HUMAN CK1 1.4e-122 414.1 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN AF-P48730-K3A P48730 1 283 415.0 No_ligand No_ligand Active DFGin 6.036 14.99 BLAminus DFGAsp-rot-in -135.79, -179.69 65.66, 57.84 196.44, 14.58 -74.43, 9.28 295.07, 110.08 -61.57, -21.47 in-in in 8.244 Saltbr-in 2.688 HRD-in -75.16, -44.32 68.95, -5.99 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.24, 137.17 APE9-dihe-na 87.75, -172.14 APE8-dihe-in -81.8, 106.79 APE8-rot-in 298.65 APE67-dihe-in -57.57, -40.66 -46.21, -33.58 APE12-dist-in 12.33 APE11-dist-in 12.46 APE10-dist-in 6.972 APE9-dist-in 3.344 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[9, 275]] 1.0 AF-P48730-K3 CK1_CSNK1D_HUMAN CK1 1.4e-122 414.1 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RCHB P48730 1 293 415.0 No_ligand No_ligand Active DFGin 5.843 14.557 BLAminus DFGAsp-rot-in -131.65, 170.96 76.64, 96.11 199.13, -27.96 -104.66, 20.03 292.76, 102.3 -66.03, -25.81 in-in in 7.929 Saltbr-in 2.638 HRD-in -82.16, -49.05 70.48, 10.61 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.36, -16.93 APE9-dihe-na -91.24, -146.45 APE8-dihe-in -101.75, 113.83 APE8-rot-in 306.19 APE67-dihe-in -56.37, -33.25 -58.53, -38.11 APE12-dist-in 12.316 APE11-dist-in 12.015 APE10-dist-in 7.0 APE9-dist-in 4.335 None None None XRAY 1.45 0.157 0.178 B 296 293 0 0 0 0 [[9, 275]] 1.0 6rch CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYSA P48730 4 294 415.0 No_ligand No_ligand Active DFGin 6.102 15.072 BLAminus DFGAsp-rot-in -135.99, -172.72 54.24, 84.3 210.35, -9.59 -98.01, 23.68 285.73, 116.84 -62.69, -28.36 in-in in 8.356 Saltbr-in 2.611 HRD-in -83.32, -46.5 68.28, 7.86 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.95, 102.73 APE9-dihe-na 151.96, -149.32 APE8-dihe-in -118.11, 114.68 APE8-rot-in 297.33 APE67-dihe-in -67.47, -40.27 -52.12, -24.47 APE12-dist-in 13.143 APE11-dist-in 12.267 APE10-dist-in 6.813 APE9-dist-in 4.11 None None None XRAY 2.3 0.238 0.276 A 296 281 10 0 0 0 [[9, 275]] 1.0 3uys CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYSB P48730 4 294 415.0 No_ligand No_ligand Active DFGin 6.122 15.305 BLAminus DFGAsp-rot-in -123.48, -176.29 49.64, 104.5 197.12, -4.32 -109.98, 26.53 290.32, 65.97 -66.14, -7.64 in-in in 8.686 Saltbr-in 2.902 HRD-in -63.12, -39.01 58.16, 15.19 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.51, 106.93 APE9-dihe-na 146.4, -128.36 APE8-dihe-in -129.25, 128.0 APE8-rot-in 311.95 APE67-dihe-in -54.57, -43.47 -56.45, -39.42 APE12-dist-in 12.939 APE11-dist-in 11.871 APE10-dist-in 6.445 APE9-dist-in 4.15 None None None XRAY 2.3 0.238 0.276 B 296 279 12 0 0 0 [[9, 275]] 1.0 3uys CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYSC P48730 4 294 415.0 No_ligand No_ligand Active DFGin 6.17 14.989 BLAminus DFGAsp-rot-in -134.31, -179.28 58.1, 91.57 210.01, -27.34 -102.86, 27.33 288.56, 103.71 -68.45, -23.02 in-in in 8.167 Saltbr-in 3.006 HRD-in -74.66, -53.28 79.91, 5.21 in-in-in SNCiii in-in ActLoopNT-in 3.101 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.65, 112.01 APE9-dihe-na 135.42, -174.74 APE8-dihe-in -92.63, 117.69 APE8-rot-in 318.84 APE67-dihe-in -76.69, -30.13 -57.91, -14.76 APE12-dist-in 12.529 APE11-dist-in 12.063 APE10-dist-in 6.4 APE9-dist-in 3.903 None None None XRAY 2.3 0.238 0.276 C 296 286 5 0 0 4 [[9, 275]] 1.0 3uys CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYSD P48730 4 294 415.0 No_ligand No_ligand Active DFGin 5.978 14.973 BLAminus DFGAsp-rot-in -135.58, 176.18 66.3, 85.15 212.85, -40.18 -100.12, 27.44 287.44, 108.47 -71.4, -34.89 in-in in 8.26 Saltbr-in 2.909 HRD-in -74.17, -45.77 69.63, -6.25 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.44, 116.33 APE9-dihe-na 132.39, -162.25 APE8-dihe-in -97.61, 129.12 APE8-rot-in 319.85 APE67-dihe-in -65.73, -32.75 -68.54, -21.24 APE12-dist-in 12.774 APE11-dist-in 12.098 APE10-dist-in 6.503 APE9-dist-in 4.271 None None None XRAY 2.3 0.238 0.276 D 296 284 7 0 0 0 [[9, 275]] 1.0 3uys CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 8D7MB P48730 2 290 415.0 No_ligand No_ligand Active DFGin 6.366 15.054 BLAminus DFGAsp-rot-in -133.02, 176.99 67.05, 83.52 191.84, -8.9 -99.86, 23.87 288.55, 76.27 -66.65, -21.08 in-in in 7.994 Saltbr-in 2.747 HRD-in -83.86, -50.81 73.21, 7.48 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.04, 138.78 APE9-dihe-na 100.9, -144.49 APE8-dihe-in -113.42, 133.79 APE8-rot-in 286.18 APE67-dihe-in -68.47, -33.95 -60.62, -36.47 APE12-dist-in 12.874 APE11-dist-in 12.443 APE10-dist-in 7.065 APE9-dist-in 3.614 None None None XRAY 2.25 0.183 0.233 B 301 289 0 0 0 0 [[9, 275]] 1.0 8d7m CK1_CSNK1D_HUMAN CK1 1.7e-122 413.8 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 8D7OB P48730 2 290 415.0 No_ligand No_ligand Active DFGin 6.707 14.954 BLAminus DFGAsp-rot-in -129.86, -179.93 67.27, 80.46 184.46, 2.21 -100.25, 21.82 286.61, 77.74 -67.58, -21.13 in-in in 8.052 Saltbr-in 2.827 HRD-in -85.94, -49.67 73.0, 5.76 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.84, 136.91 APE9-dihe-na 109.35, -145.96 APE8-dihe-in -119.11, 136.0 APE8-rot-in 295.77 APE67-dihe-in -64.5, -36.47 -59.05, -40.84 APE12-dist-in 13.253 APE11-dist-in 12.2 APE10-dist-in 6.908 APE9-dist-in 3.455 None None None XRAY 1.65 0.174 0.209 B 301 289 0 0 0 0 [[9, 275]] 1.0 8d7o CK1_CSNK1D_HUMAN CK1 1.7e-122 413.8 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 8D7PB P48730 2 290 415.0 No_ligand No_ligand Active DFGin 5.859 14.67 BLAminus DFGAsp-rot-in -130.49, 172.66 68.65, 91.76 203.99, -28.52 -101.03, 25.87 297.23, 90.22 -72.86, -19.19 in-in in 8.015 Saltbr-in 2.456 HRD-in -85.55, -52.52 74.69, 6.14 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.07, 117.73 APE9-dihe-na -149.93, -159.97 APE8-dihe-in -104.9, 114.63 APE8-rot-in 293.84 APE67-dihe-in -64.02, -31.31 -56.89, -40.01 APE12-dist-in 13.303 APE11-dist-in 10.243 APE10-dist-in 7.565 APE9-dist-in 4.675 None None None XRAY 2.25 0.199 0.251 B 301 289 0 0 0 0 [[9, 275]] 1.0 8d7p CK1_CSNK1D_HUMAN CK1 1.7e-122 413.8 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 4TN6B P48730 2 292 415.0 No_ligand No_ligand Active DFGin 6.047 14.793 BLAminus DFGAsp-rot-in -131.93, 175.74 67.68, 89.2 222.06, -56.0 -98.57, 20.63 293.04, 101.16 -63.36, -31.28 in-in in 8.009 Saltbr-in 2.892 HRD-in -77.62, -48.19 67.28, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.84, 98.76 APE9-dihe-na 123.78, -164.81 APE8-dihe-in -90.48, 131.01 APE8-rot-in 310.94 APE67-dihe-in -53.03, -41.99 -58.19, -43.36 APE12-dist-in 11.393 APE11-dist-in 11.652 APE10-dist-in 6.054 APE9-dist-in 3.92 None None None XRAY 2.41 0.19 0.239 B 318 285 3 0 0 0 [[9, 275]] 1.0 4tn6 CK1_CSNK1D_HUMAN CK1 2.1e-122 413.5 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6PXPA P48730 2 293 415.0 No_ligand No_ligand Active DFGin 5.983 14.851 BLAminus DFGAsp-rot-in -137.52, 172.85 65.52, 95.22 204.85, -30.47 -107.76, 25.56 291.17, 109.72 -73.49, -24.5 in-in in 8.254 Saltbr-in 2.912 HRD-in -81.44, -47.41 77.01, 0.83 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.57, 122.69 APE9-dihe-na 111.56, 179.84 APE8-dihe-in -78.24, 136.92 APE8-rot-in 308.99 APE67-dihe-in -60.53, -35.81 -68.97, -29.32 APE12-dist-in 10.48 APE11-dist-in 11.788 APE10-dist-in 6.065 APE9-dist-in 3.705 K171E None None XRAY 2.35 0.201 0.243 A 294 288 4 0 0 0 [[9, 275]] 1.0 6pxp CK1_CSNK1D_HUMAN CK1 4.5e-122 412.4 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 8IZCB P48730 5 294 415.0 S93:60303 Type1 Active DFGin 5.795 15.13 BLAminus DFGAsp-rot-in -127.75, 168.53 74.17, 99.03 200.29, -33.89 -107.93, 19.19 290.65, 101.85 -62.94, -27.99 in-in in 8.485 Saltbr-in 3.369 HRD-in -80.22, -50.17 74.11, 7.08 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.14, 152.75 APE9-dihe-na 103.35, -169.22 APE8-dihe-in -99.98, 119.89 APE8-rot-in 309.34 APE67-dihe-in -53.04, -39.2 -57.61, -35.96 APE12-dist-in 11.953 APE11-dist-in 12.011 APE10-dist-in 6.408 APE9-dist-in 3.978 None None None XRAY 1.45 0.192 0.207 B 291 290 0 0 0 0 [[9, 275]] 1.0 8izc CK1_CSNK1D_HUMAN CK1 1.5e-122 414.0 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 5IH6A P48730 2 293 415.0 AUG:305 Type1 Active DFGin 5.9 15.482 BLAminus DFGAsp-rot-in -128.7, 171.19 73.47, 91.55 204.84, -39.96 -103.56, 28.82 292.29, 98.11 -73.23, -29.86 in-in in 8.572 Saltbr-in 3.419 HRD-in -87.62, -49.57 76.35, -3.83 in-in-in SNCiii in-in ActLoopNT-in 3.002 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.33, 137.88 APE9-dihe-na 98.97, -178.76 APE8-dihe-in -78.42, 134.27 APE8-rot-in 320.15 APE67-dihe-in -51.8, -40.15 -63.26, -37.67 APE12-dist-in 12.526 APE11-dist-in 11.843 APE10-dist-in 6.114 APE9-dist-in 3.84 None None None XRAY 2.3 0.234 0.26 A 294 286 6 0 0 0 [[9, 275]] 1.0 5ih6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FC P48730 4 294 415.0 ADN:307 Type1 Active DFGin 6.287 14.774 BLAminus DFGAsp-rot-in -127.27, 170.02 72.27, 90.59 205.81, -40.83 -100.52, 22.08 289.81, 85.32 -63.29, -31.3 in-in in 7.933 Saltbr-in 2.63 HRD-in -80.78, -51.31 76.2, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.83, -40.42 APE9-dihe-na -88.08, -154.15 APE8-dihe-in -92.07, 119.61 APE8-rot-in 316.8 APE67-dihe-in -56.43, -36.06 -56.0, -37.52 APE12-dist-in 12.693 APE11-dist-in 12.117 APE10-dist-in 6.391 APE9-dist-in 4.324 None TPO220 TPO220 XRAY 1.96 0.19 0.221 C 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7P7FD P48730 4 294 415.0 ADN:309 Type1 Active DFGin 6.224 14.767 BLAminus DFGAsp-rot-in -126.64, 169.11 73.89, 91.36 203.81, -40.27 -99.69, 21.56 289.8, 84.96 -66.02, -29.96 in-in in 7.952 Saltbr-in 2.667 HRD-in -81.57, -51.69 78.22, 8.75 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.24, -37.1 APE9-dihe-na -85.95, -158.82 APE8-dihe-in -90.13, 119.34 APE8-rot-in 319.47 APE67-dihe-in -54.92, -36.79 -58.02, -35.64 APE12-dist-in 13.37 APE11-dist-in 12.222 APE10-dist-in 6.519 APE9-dist-in 4.362 None TPO220 TPO220 XRAY 1.96 0.19 0.221 D 296 285 6 0 0 6 [[9, 275]] 1.0 7p7f CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QR9B P48730 2 294 415.0 EZQ:304 Type1 Active DFGin 5.736 15.259 BLAminus DFGAsp-rot-in -137.93, 175.93 70.34, 95.42 191.95, 8.46 -112.76, 22.31 285.98, 104.42 -71.79, -20.33 in-in in 8.494 Saltbr-in 3.033 HRD-in -85.88, -57.56 74.9, 13.35 in-in-in SNCiii in-in ActLoopNT-in 3.121 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.3, 111.05 APE9-dihe-na 138.52, -161.09 APE8-dihe-in -99.08, 116.92 APE8-rot-in 313.8 APE67-dihe-in -61.25, -36.96 -59.19, -34.06 APE12-dist-in 12.385 APE11-dist-in 12.095 APE10-dist-in 6.629 APE9-dist-in 4.19 None None None XRAY 2.3 0.254 0.305 B 296 291 2 0 0 0 [[9, 275]] 1.0 7qr9 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRAA P48730 3 294 415.0 EYI:307 Type1 Active DFGin 5.739 15.212 BLAminus DFGAsp-rot-in -129.63, 174.95 73.0, 97.71 193.37, 7.47 -116.41, 24.77 288.45, 102.87 -71.56, -22.75 in-in in 8.527 Saltbr-in 2.784 HRD-in -85.23, -60.7 76.19, 18.85 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.29, -40.65 APE9-dihe-na -87.45, -140.73 APE8-dihe-in -96.68, 126.6 APE8-rot-in 315.63 APE67-dihe-in -60.1, -39.91 -69.45, -28.12 APE12-dist-in 12.097 APE11-dist-in 12.053 APE10-dist-in 6.433 APE9-dist-in 3.891 None None None XRAY 2.4 0.241 0.282 A 296 289 3 0 0 0 [[9, 275]] 1.0 7qra CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRAB P48730 3 294 415.0 EYI:308 Type1 Active DFGin 5.764 15.183 BLAminus DFGAsp-rot-in -130.87, 174.1 72.72, 98.11 193.31, 9.31 -115.7, 24.4 288.11, 100.43 -70.38, -23.64 in-in in 8.561 Saltbr-in 2.768 HRD-in -84.79, -60.13 77.89, 15.35 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.51, -41.22 APE9-dihe-na -87.16, -142.78 APE8-dihe-in -95.48, 126.32 APE8-rot-in 317.4 APE67-dihe-in -62.31, -40.0 -66.85, -28.92 APE12-dist-in 12.377 APE11-dist-in 12.072 APE10-dist-in 6.452 APE9-dist-in 3.944 None None None XRAY 2.4 0.241 0.282 B 296 289 3 0 0 0 [[9, 275]] 1.0 7qra CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRAC P48730 3 294 415.0 EYI:305 Type1 Active DFGin 5.844 15.171 BLAminus DFGAsp-rot-in -126.88, 173.42 75.27, 97.85 193.02, 5.46 -115.56, 23.0 289.2, 100.23 -73.01, -21.24 in-in in 8.536 Saltbr-in 2.851 HRD-in -84.69, -59.53 80.0, 13.31 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.55, 110.63 APE9-dihe-na 137.63, -156.44 APE8-dihe-in -96.52, 125.23 APE8-rot-in 317.11 APE67-dihe-in -61.28, -38.81 -74.42, -24.35 APE12-dist-in 13.448 APE11-dist-in 12.036 APE10-dist-in 6.428 APE9-dist-in 4.257 None None None XRAY 2.4 0.241 0.282 C 296 280 12 0 0 9 [[9, 275]] 1.0 7qra CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRAD P48730 3 294 415.0 EYI:304 Type1 Active DFGin 5.888 15.199 BLAminus DFGAsp-rot-in -125.88, 173.32 76.1, 97.96 192.82, 8.62 -116.31, 23.64 289.96, 100.23 -73.22, -20.1 in-in in 8.622 Saltbr-in 2.839 HRD-in -83.39, -59.49 80.05, 13.06 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.71, 111.44 APE9-dihe-na 139.23, -155.32 APE8-dihe-in -97.46, 125.75 APE8-rot-in 316.99 APE67-dihe-in -61.28, -37.47 -73.02, -28.07 APE12-dist-in 13.411 APE11-dist-in 11.996 APE10-dist-in 6.435 APE9-dist-in 4.231 None None None XRAY 2.4 0.241 0.282 D 296 280 12 0 0 9 [[9, 275]] 1.0 7qra CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRBA P48730 3 294 415.0 EX9:303 Type1 Active DFGin 5.786 14.749 BLAminus DFGAsp-rot-in -138.57, 173.71 74.23, 97.05 208.22, -38.35 -111.52, 23.54 292.13, 96.9 -64.17, -33.44 in-in in 8.054 Saltbr-in 3.32 HRD-in -80.6, -62.98 85.02, 10.42 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.53, -38.97 APE9-dihe-na -79.34, -143.1 APE8-dihe-in -104.26, 120.14 APE8-rot-in 303.67 APE67-dihe-in -58.5, -38.92 -56.29, -38.68 APE12-dist-in 11.569 APE11-dist-in 12.023 APE10-dist-in 6.479 APE9-dist-in 3.619 None None None XRAY 2.6 0.231 0.273 A 296 292 0 0 0 0 [[9, 275]] 1.0 7qrb CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRBB P48730 3 294 415.0 EX9:304 Type1 Active DFGin 5.864 14.858 BLAminus DFGAsp-rot-in -136.87, 171.91 74.6, 98.93 207.03, -37.5 -112.49, 24.79 293.01, 96.72 -66.73, -32.74 in-in in 8.061 Saltbr-in 3.313 HRD-in -79.65, -62.36 86.77, 5.68 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -93.7, -39.26 APE9-dihe-na -82.5, -142.47 APE8-dihe-in -103.22, 119.83 APE8-rot-in 303.38 APE67-dihe-in -57.15, -38.6 -56.04, -38.93 APE12-dist-in 11.587 APE11-dist-in 11.936 APE10-dist-in 6.251 APE9-dist-in 3.66 None None None XRAY 2.6 0.231 0.273 B 296 286 6 0 0 6 [[9, 275]] 1.0 7qrb CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7QRBC P48730 3 294 415.0 EX9:304 Type1 Active DFGin 5.83 14.833 BLAminus DFGAsp-rot-in -136.6, 172.53 75.75, 98.41 206.87, -35.26 -112.93, 24.4 292.54, 96.74 -63.85, -34.66 in-in in 8.075 Saltbr-in 3.337 HRD-in -77.66, -63.11 86.68, 6.65 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.13, -39.43 APE9-dihe-na -82.01, -141.99 APE8-dihe-in -104.01, 120.43 APE8-rot-in 304.37 APE67-dihe-in -57.15, -38.63 -55.0, -40.36 APE12-dist-in 11.611 APE11-dist-in 11.922 APE10-dist-in 6.301 APE9-dist-in 3.646 None None None XRAY 2.6 0.231 0.273 C 296 292 0 0 0 0 [[9, 275]] 1.0 7qrb CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1