AGC / All / All

Total number of chains: 707
Active chains: 293
Total number of genes: 60
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 511 72.3% AF-P31749-K1A
DFGin ABAminus 92 13.0% 4NW6A
DFGout None 30 4.2% 4NUSA
DFGin None 24 3.4% 6PJXA
DFGout BBAminus 19 2.7% 6HHJA
DFGinter None 12 1.7% 3TWJB
None None 11 1.6% 9ZBKE
DFGin BLAplus 4 0.6% 8XOVA
DFGin BLBplus 3 0.4% 2Z7RA
DFGin BLBminus 1 0.1% 7S26C

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.048 13.113 BLAminus DFGAsp-rot-in -112.5, -177.27 66.46, 90.66 198.98, 2.5 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.651 Saltbr-in 2.978 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.814 APE11-dist-in 11.718 APE10-dist-in 6.07 APE9-dist-in 4.069 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.075 13.046 BLAminus DFGAsp-rot-in -112.98, 175.61 60.18, 117.01 197.33, 0.64 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.766 Saltbr-in 2.665 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.77 APE11-dist-in 11.686 APE10-dist-in 6.125 APE9-dist-in 4.285 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN AF-P31749-K1A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 6.263 13.145 BLAminus DFGAsp-rot-in -114.62, -167.38 40.57, 67.78 207.16, 11.22 -78.23, 20.61 301.26, 84.0 -56.98, -40.88 in-in in 8.68 Saltbr-in 2.68 HRD-in -78.93, -42.17 64.1, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.25, 159.39 APE9-dihe-na 136.34, -176.15 APE8-dihe-in -90.74, 129.43 APE8-rot-in 299.37 APE67-dihe-in -70.7, -14.81 -47.91, -45.56 APE12-dist-in 8.322 APE11-dist-in 11.748 APE10-dist-in 6.046 APE9-dist-in 3.779 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[150, 408]] 1.0 AF-P31749-K1 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN AF-P31749-K3A P31749 142 416 480.0 No_ligand No_ligand Active DFGin 5.861 13.331 BLAminus DFGAsp-rot-in -119.71, -175.9 43.31, 87.62 211.71, -12.35 -90.32, 18.66 297.34, 81.96 -61.74, -29.8 in-in in 8.79 Saltbr-in 2.698 HRD-in -81.85, -49.76 69.24, 0.24 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.64, 153.01 APE9-dihe-na 135.73, 179.27 APE8-dihe-in -81.81, 130.02 APE8-rot-in 289.58 APE67-dihe-in -69.79, -14.8 -47.58, -43.93 APE12-dist-in 8.487 APE11-dist-in 11.473 APE10-dist-in 5.866 APE9-dist-in 4.262 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[150, 408]] 1.0 AF-P31749-K3 AGC_AKT1_HUMAN AGC 1.1e-99 338.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6BUUA P31749 144 478 480.0 No_ligand No_ligand Inactive DFGin 6.46 13.561 BLAminus DFGAsp-rot-out -129.81, 166.71 63.43, 103.36 323.09, -19.53 -112.37, 8.26 300.4, 87.1 -62.82, -21.63 in-in in 8.565 Saltbr-in 3.321 HRD-in -78.21, -43.42 65.34, -10.93 in-in-in SNCiii in-in ActLoopNT-in 2.785 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.8, 159.61 APE9-dihe-na 139.87, -147.27 APE8-dihe-in -120.07, 129.86 APE8-rot-in 299.9 APE67-dihe-in -65.46, -21.29 -53.54, -42.3 APE12-dist-in 8.72 APE11-dist-in 11.732 APE10-dist-in 6.238 APE9-dist-in 4.085 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 A 337 323 0 0 0 0 [[150, 408]] 1.0 6buu AGC_AKT1_HUMAN AGC 2.3e-99 337.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6BUUB P31749 144 477 480.0 No_ligand No_ligand Inactive DFGin 6.422 13.475 BLAminus DFGAsp-rot-out -128.87, 158.63 82.78, 97.45 277.8, 19.24 -111.26, 12.46 302.86, 92.31 -62.01, -29.27 in-in in 8.622 Saltbr-in 2.612 HRD-in -74.01, -46.33 68.16, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 167.54 APE9-dihe-na 132.85, -158.22 APE8-dihe-in -118.97, 130.29 APE8-rot-in 299.43 APE67-dihe-in -70.47, -18.64 -52.17, -43.37 APE12-dist-in 8.8 APE11-dist-in 11.759 APE10-dist-in 6.078 APE9-dist-in 3.935 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.4 0.185 0.23 B 337 319 0 0 0 0 [[150, 408]] 1.0 6buu AGC_AKT1_HUMAN AGC 2.3e-99 337.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6NPZA P31749 142 478 480.0 No_ligand No_ligand Inactive DFGin 6.243 13.517 BLAminus DFGAsp-rot-out -119.48, 178.99 63.44, 89.04 294.57, 11.54 -107.85, 9.08 296.64, 94.01 -63.0, -21.88 in-in in 8.904 Saltbr-in 3.005 HRD-in -76.14, -48.91 69.19, -6.3 in-in-in SNCiii in-in ActLoopNT-in 2.995 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.99, 160.01 APE9-dihe-na 134.89, -153.13 APE8-dihe-in -119.22, 128.69 APE8-rot-in 299.44 APE67-dihe-in -61.81, -21.05 -49.68, -44.36 APE12-dist-in 8.283 APE11-dist-in 11.557 APE10-dist-in 5.957 APE9-dist-in 3.903 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 A 358 322 0 0 0 0 [[150, 408]] 1.0 6npz AGC_AKT1_HUMAN AGC 2.8e-99 337.5 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6NPZB P31749 141 477 480.0 No_ligand No_ligand Inactive DFGin 6.492 13.71 BLAminus DFGAsp-rot-out -117.03, 171.77 71.96, 91.9 288.36, 14.62 -107.91, 11.41 295.22, 94.23 -65.12, -23.31 in-in in 8.806 Saltbr-in 3.089 HRD-in -77.35, -47.58 69.03, -7.27 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.06, 158.85 APE9-dihe-na 134.94, -150.01 APE8-dihe-in -122.61, 125.21 APE8-rot-in 296.0 APE67-dihe-in -68.07, -17.45 -48.75, -43.62 APE12-dist-in 8.484 APE11-dist-in 11.691 APE10-dist-in 6.044 APE9-dist-in 3.856 None TPO308,SEP473,SEP477 TPO308,SEP473,SEP477 XRAY 2.12 0.188 0.241 B 358 323 0 0 0 0 [[150, 408]] 1.0 6npz AGC_AKT1_HUMAN AGC 2.8e-99 337.5 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4GV1A P31749 144 477 480.0 0XZ:60501 Type1 Inactive DFGin 6.488 13.562 BLAminus DFGAsp-rot-out -122.36, 161.99 68.48, 91.61 283.11, -76.96 -104.89, 11.22 297.02, 96.69 -63.45, -24.57 in-in in 8.817 Saltbr-in 2.472 HRD-in -73.6, -46.3 69.86, -10.37 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.52, 165.79 APE9-dihe-na 129.18, -173.05 APE8-dihe-in -103.26, 131.39 APE8-rot-in 301.03 APE67-dihe-in -66.34, -18.55 -46.14, -49.45 APE12-dist-in 8.481 APE11-dist-in 11.553 APE10-dist-in 5.998 APE9-dist-in 4.098 None TPO308 TPO308 XRAY 1.49 0.182 0.21 A 340 329 0 0 0 0 [[150, 408]] 1.0 4gv1 AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OCBA P31749 144 478 480.0 XM1:1 Type1 Inactive DFGin 6.638 13.803 BLAminus DFGAsp-rot-out -116.95, 176.33 66.85, 80.21 309.05, -63.89 -101.71, 15.06 291.18, 80.12 -62.95, -27.15 in-in in 8.771 Saltbr-in 2.77 HRD-in -68.69, -47.69 74.78, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.18, 163.1 APE9-dihe-na 135.15, -135.96 APE8-dihe-in -136.2, 122.51 APE8-rot-in 298.45 APE67-dihe-in -66.42, -19.48 -44.24, -42.98 APE12-dist-in 8.435 APE11-dist-in 11.489 APE10-dist-in 5.888 APE9-dist-in 4.058 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 A 341 316 0 0 0 0 [[150, 408]] 1.0 3ocb AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OCBB P31749 144 478 480.0 XM1:2 Type1 Inactive DFGin 6.332 13.399 BLAminus DFGAsp-rot-out -134.12, 162.45 65.57, 102.27 297.48, -72.36 -117.67, 11.66 296.51, 86.34 -58.99, -28.22 in-in in 8.815 Saltbr-in 2.871 HRD-in -68.9, -44.89 75.11, -22.64 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.43, 165.77 APE9-dihe-na 133.07, -137.47 APE8-dihe-in -130.52, 128.21 APE8-rot-in 301.82 APE67-dihe-in -61.46, -22.02 -42.63, -52.7 APE12-dist-in 8.732 APE11-dist-in 11.603 APE10-dist-in 6.079 APE9-dist-in 4.134 S473D TPO308 TPO308 XRAY 2.7 0.217 0.282 B 341 320 0 0 0 0 [[150, 408]] 1.0 3ocb AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OW4A P31749 144 478 480.0 SMY:60001 Type1 Active DFGin 6.386 13.523 BLAminus DFGAsp-rot-in -119.32, 159.71 79.63, 82.83 211.82, -24.97 -104.78, 4.01 298.86, 82.1 -54.94, -24.29 in-in in 8.955 Saltbr-in 2.902 HRD-in -70.99, -49.36 69.67, -8.21 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.63, 156.89 APE9-dihe-na 142.86, -142.49 APE8-dihe-in -124.25, 130.13 APE8-rot-in 298.03 APE67-dihe-in -63.26, -12.53 -44.97, -47.55 APE12-dist-in 8.407 APE11-dist-in 11.499 APE10-dist-in 5.943 APE9-dist-in 4.122 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 A 341 318 0 0 0 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3OW4B P31749 144 478 480.0 SMY:60002 Type1 Active DFGin 6.468 13.471 BLAminus DFGAsp-rot-in -110.6, 166.76 74.64, 94.72 203.85, -22.62 -107.78, 10.54 297.92, 88.21 -53.21, -30.59 in-in in 9.014 Saltbr-in 2.873 HRD-in -68.95, -46.49 77.32, -19.31 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 158.48 APE9-dihe-na 136.94, -160.6 APE8-dihe-in -112.04, 132.88 APE8-rot-in 279.55 APE67-dihe-in -64.15, -17.53 -43.71, -49.28 APE12-dist-in 8.567 APE11-dist-in 11.482 APE10-dist-in 6.0 APE9-dist-in 4.209 S473D TPO308 TPO308 XRAY 2.6 0.197 0.268 B 341 318 0 0 0 0 [[150, 408]] 1.0 3ow4 AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3QKLA P31749 144 478 480.0 SMR:60001 Type1 Inactive DFGin 6.338 13.63 BLAminus DFGAsp-rot-out -120.73, 173.12 65.05, 75.71 292.64, 83.84 -95.61, 13.62 302.87, 90.58 -65.29, -24.68 in-in in 9.025 Saltbr-in 2.669 HRD-in -79.32, -50.18 77.61, -12.23 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.72, 167.27 APE9-dihe-na 129.72, -141.45 APE8-dihe-in -129.9, 128.86 APE8-rot-in 291.61 APE67-dihe-in -64.11, -23.78 -46.08, -46.14 APE12-dist-in 8.149 APE11-dist-in 11.608 APE10-dist-in 5.994 APE9-dist-in 3.707 S473D TPO308 TPO308 XRAY 1.9 0.196 0.243 A 341 318 0 0 0 0 [[150, 408]] 1.0 3qkl AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3QKMA P31749 144 478 480.0 SM9:1 Type1 Inactive DFGin 6.551 13.483 BLAminus DFGAsp-rot-out -120.8, 163.74 70.66, 92.07 275.5, 20.26 -106.66, 15.27 300.92, 94.29 -62.34, -28.26 in-in in 9.201 Saltbr-in 2.666 HRD-in -70.68, -45.98 71.02, -16.64 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.62, 157.36 APE9-dihe-na 116.69, 169.89 APE8-dihe-in -83.27, 128.83 APE8-rot-in 296.3 APE67-dihe-in -66.75, -19.54 -36.8, -50.73 APE12-dist-in 8.46 APE11-dist-in 11.525 APE10-dist-in 5.915 APE9-dist-in 4.629 S473D TPO308 TPO308 XRAY 2.2 0.191 0.252 A 341 330 0 0 0 0 [[150, 408]] 1.0 3qkm AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.496 13.423 BLAminus DFGAsp-rot-in -130.08, 156.46 77.16, 99.77 202.35, -40.94 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.958 Saltbr-in 2.452 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.512 APE10-dist-in 6.011 APE9-dist-in 4.443 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341 330 0 0 0 0 [[150, 408]] 1.0 4ekl AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3CQUA P31749 144 478 480.0 CQU:60999 Type1 Inactive DFGin 6.162 12.752 BLAminus DFGAsp-rot-in -125.29, 173.04 74.77, 101.51 213.14, -14.11 -111.55, 14.45 309.48, 77.95 -55.91, -32.71 in-out in 9.246 Saltbr-out 4.113 HRD-in -63.98, -47.97 77.74, -15.86 out-in-in SNCoii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.44, 176.23 APE9-dihe-na 125.93, -142.07 APE8-dihe-in -126.34, 131.3 APE8-rot-in 289.37 APE67-dihe-in -62.32, -24.17 -48.41, -45.96 APE12-dist-in 8.309 APE11-dist-in 11.455 APE10-dist-in 6.059 APE9-dist-in 3.993 S473D TPO308 TPO308 XRAY 2.2 0.207 0.283 A 342 319 0 0 0 0 [[150, 408]] 1.0 3cqu AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3CQWA P31749 144 478 480.0 CQW:60999 Type1 Inactive DFGin 6.338 13.09 BLAminus DFGAsp-rot-out -122.41, 167.11 74.19, 82.7 288.06, 80.32 -100.79, 9.25 295.72, 101.99 -67.19, -25.09 in-in in 8.608 Saltbr-in 3.437 HRD-in -79.68, -40.11 70.25, -18.88 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.61, 166.29 APE9-dihe-na 132.98, -141.71 APE8-dihe-in -134.77, 132.14 APE8-rot-in 286.58 APE67-dihe-in -67.95, -20.8 -49.28, -45.72 APE12-dist-in 8.374 APE11-dist-in 11.536 APE10-dist-in 5.934 APE9-dist-in 3.951 S473D TPO308 TPO308 XRAY 2.0 0.203 0.257 A 342 319 0 0 0 0 [[150, 408]] 1.0 3cqw AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3MV5A P31749 144 477 480.0 XFE:60999 Type1 Inactive DFGin 6.512 13.107 BLAminus DFGAsp-rot-out -110.68, 173.87 55.61, 106.15 300.15, -52.2 -116.13, 8.16 292.02, 88.05 -68.88, -21.78 in-in in 8.573 Saltbr-in 2.645 HRD-in -81.07, -37.62 75.3, -21.62 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.23, 167.83 APE9-dihe-na 126.38, -137.1 APE8-dihe-in -133.69, 127.23 APE8-rot-in 287.39 APE67-dihe-in -69.19, -14.76 -48.38, -39.25 APE12-dist-in 8.467 APE11-dist-in 11.692 APE10-dist-in 6.145 APE9-dist-in 4.185 S473D TPO308 TPO308 XRAY 2.47 0.205 0.282 A 342 316 0 0 0 0 [[150, 408]] 1.0 3mv5 AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3MVHA P31749 145 476 480.0 WFE:999 Type1 Inactive DFGin 6.609 13.205 BLAminus DFGAsp-rot-out -120.33, 157.64 77.18, 89.81 299.83, -54.57 -109.14, 14.39 295.05, 87.49 -62.89, -24.97 in-in in 8.782 Saltbr-in 2.62 HRD-in -82.77, -44.94 75.58, -15.19 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.65, 167.39 APE9-dihe-na 135.14, -139.29 APE8-dihe-in -137.11, 131.02 APE8-rot-in 291.39 APE67-dihe-in -63.24, -17.86 -53.88, -42.66 APE12-dist-in 8.149 APE11-dist-in 11.591 APE10-dist-in 5.855 APE9-dist-in 3.756 S473D TPO308 TPO308 XRAY 2.01 0.181 0.23 A 342 312 0 0 0 0 [[150, 408]] 1.0 3mvh AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6CCYA P31749 144 983 480.0 EX4:60501 Type1 Inactive DFGin 6.833 14.216 BLAminus DFGAsp-rot-out -118.22, 172.28 65.22, 87.23 292.73, 88.69 -99.08, 6.12 296.87, 97.72 -61.52, -36.28 in-in in 9.387 Saltbr-in 2.725 HRD-in -70.12, -46.7 65.1, -15.97 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 164.77 APE9-dihe-na 117.98, 177.81 APE8-dihe-in -89.16, 122.56 APE8-rot-in 287.17 APE67-dihe-in -60.32, -21.6 -32.19, -51.09 APE12-dist-in 8.32 APE11-dist-in 11.49 APE10-dist-in 5.811 APE9-dist-in 4.408 N199S,S396P,E397S,T433V TPO308 TPO308 XRAY 2.18 0.237 0.276 A 343 307 0 0 0 0 [[150, 408]] 1.0 6ccy AGC_AKT1_HUMAN AGC 4.2e-99 336.9 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3QKKA P31749 144 478 480.0 SMH:60001 Type1.5_Front Inactive DFGin 6.383 13.598 BLAminus DFGAsp-rot-out -116.54, -179.44 52.7, 85.0 291.28, -88.93 -102.02, 14.36 303.33, 93.01 -66.45, -23.02 in-in in 8.916 Saltbr-in 2.342 HRD-in -78.65, -51.68 79.72, -12.12 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.57, 164.52 APE9-dihe-na 135.56, -139.12 APE8-dihe-in -127.86, 127.7 APE8-rot-in 299.02 APE67-dihe-in -62.38, -25.83 -44.42, -46.66 APE12-dist-in 8.22 APE11-dist-in 11.566 APE10-dist-in 6.028 APE9-dist-in 3.779 S473D TPO308 TPO308 XRAY 2.3 0.202 0.25 A 341 327 0 0 0 0 [[150, 408]] 1.0 3qkk AGC_AKT1_HUMAN AGC 2.4e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UVYA P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.147 9.117 BBAminus DFGAsp-rot-in -87.71, 159.46 -125.79, 51.81 179.25, 28.07 -104.71, 8.89 306.76, 157.9 -76.01, 144.81 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.44, -49.7 65.22, 18.47 none-out-out SNCnoo out-out ActLoopNT-out 15.329 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -75.27, -63.55 APE9-dihe-na -84.1, -150.14 APE8-dihe-in -112.51, 118.73 APE8-rot-in 303.11 APE67-dihe-in -70.02, -8.73 -61.09, -34.89 APE12-dist-in 11.509 APE11-dist-in 11.913 APE10-dist-in 7.703 APE9-dist-out 6.561 E17K None None XRAY 2.11 0.209 0.255 A 438 396 21 0 0 7 [[150, 408]] 1.0 8uvy AGC_AKT1_HUMAN AGC 5.1e-99 336.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW2A P31749 4 437 480.0 XOO:60502 Allosteric Inactive DFGout 19.594 9.174 BBAminus DFGAsp-rot-in -85.5, 157.67 -121.72, 55.74 183.31, 24.74 -105.08, 2.24 304.7, 161.96 -67.3, 146.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.89, -48.3 59.85, 6.57 none-out-out SNCnoo out-out ActLoopNT-out 13.673 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -78.7, 9.37 APE9-dihe-na -151.7, -145.87 APE8-dihe-in -109.15, 106.27 APE8-rot-out 18.96 APE67-dihe-in -70.15, -8.9 -92.15, -6.4 APE12-dist-out 18.057 APE11-dist-out 14.765 APE10-dist-out 10.604 APE9-dist-out 11.153 None None None XRAY 2.2 0.223 0.279 A 438 392 19 0 0 7 [[150, 408]] 1.0 8uw2 AGC_AKT1_HUMAN AGC 5.1e-99 336.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW9A P31749 3 428 480.0 XQ2:60501 Allosteric Inactive DFGout 18.976 9.3 BBAminus DFGAsp-rot-in -90.79, 158.27 -126.08, 50.43 177.26, 28.29 -104.96, 7.49 302.98, 161.85 -82.17, 151.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.58, -46.97 73.31, -13.02 none-out-out SNCnoo out-out ActLoopNT-out 15.346 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -78.06, -70.69 APE9-dihe-na -63.13, 144.96 APE8-dihe-in -69.73, 119.44 APE8-rot-in 308.33 APE67-dihe-in -66.64, -12.63 -58.13, -37.16 APE12-dist-in 12.561 APE11-dist-in 12.026 APE10-dist-in 7.549 APE9-dist-out 6.208 None None None XRAY 1.9 0.207 0.245 A 438 388 19 0 0 7 [[150, 408]] 1.0 8uw9 AGC_AKT1_HUMAN AGC 5.1e-99 336.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 8UW7A P31749 3 439 480.0 XOO:60502 Allosteric Inactive DFGout 19.268 9.131 BBAminus DFGAsp-rot-in -88.27, 162.56 -129.0, 47.08 188.5, 25.29 -101.62, 6.17 304.62, 157.46 -65.02, 141.6 out-out out 14.185 Saltbr-out 16.163 HRD-in -77.74, -48.14 69.36, -7.13 out-out-out SNCooo out-out ActLoopNT-out 15.133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.57 APE8-dihe-in -110.93, 76.79 APE8-rot-out 38.95 APE67-dihe-in -76.05, -14.39 -64.32, -17.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.831 None None YCM77,YCM296 XRAY 1.972 0.22 0.265 A 438 399 17 0 0 12 [[150, 408]] 1.0 8uw7 AGC_AKT1_HUMAN AGC 5.1e-99 336.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 3O96A P31749 2 429 480.0 IQO:444 Allosteric Inactive DFGout 16.13 7.768 BBAminus DFGAsp-rot-in -84.04, 164.11 -138.96, 67.69 179.82, 23.08 -114.58, 18.46 294.17, 141.85 -57.09, 121.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.54, -46.27 73.79, -8.96 none-out-none SNCnon out-none ActLoopNT-out 14.705 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.73, -20.88 999.0, -53.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.7 0.249 0.308 A 446 367 24 0 0 14 [[150, 408]] 1.0 3o96 AGC_AKT1_HUMAN AGC 5.3e-99 336.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHHA P31749 2 439 480.0 G4Q:501 Allosteric Inactive DFGout 19.432 8.904 BBAminus DFGAsp-rot-in -82.84, 168.78 -138.99, 51.81 176.97, 22.7 -104.05, 22.45 309.63, 151.96 -74.89, 142.62 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.92, -45.22 71.01, -6.93 none-out-out SNCnoo out-out ActLoopNT-out 15.659 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.4 APE8-dihe-out -68.07, -39.94 APE8-rot-out 43.05 APE67-dihe-in -61.63, -40.25 -82.49, 7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.39 E114A,E115A,E116A None None XRAY 2.7 0.217 0.266 A 446 379 25 0 0 11 [[150, 408]] 1.0 6hhh AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHJA P31749 3 444 480.0 G4H:501 Allosteric Inactive DFGout 18.637 9.927 BBAminus DFGAsp-rot-in -85.85, 154.25 -131.76, 65.33 180.56, 26.36 -114.43, 2.7 306.85, 152.03 -81.33, 157.37 out-out out 16.597 Saltbr-out 20.784 HRD-in -70.38, -43.13 62.3, -0.73 out-out-out SNCooo out-out ActLoopNT-out 15.398 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -96.59, 105.04 APE9-dihe-na 69.68, -150.96 APE8-dihe-in -112.16, 140.11 APE8-rot-out 58.43 APE67-dihe-in -58.84, -27.51 -94.58, 2.39 APE12-dist-out 16.493 APE11-dist-out 16.034 APE10-dist-out 10.684 APE9-dist-out 11.298 E114A,E115A,E116A None None XRAY 2.3 0.223 0.243 A 446 410 0 0 0 0 [[150, 408]] 1.0 6hhj AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6S9WA P31749 3 444 480.0 L1Z:501 Allosteric Inactive DFGout 18.014 9.778 BBAminus DFGAsp-rot-in -88.23, 159.68 -135.32, 63.28 177.4, 30.85 -108.07, 5.2 307.51, 150.05 -79.62, 159.51 out-out out 16.719 Saltbr-out 21.04 HRD-in -77.04, -47.59 74.55, -19.15 out-out-out SNCooo out-out ActLoopNT-out 15.677 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -115.76, 103.74 APE9-dihe-na 82.07, -166.58 APE8-dihe-in -98.52, 141.96 APE8-rot-out 173.15 APE67-dihe-in -62.82, -22.8 -94.37, -0.32 APE12-dist-out 16.616 APE11-dist-out 16.139 APE10-dist-out 10.913 APE9-dist-out 11.124 E114A,E115A,E116A None None XRAY 2.3 0.21 0.263 A 446 411 2 0 0 2 [[150, 408]] 1.0 6s9w AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EJNA P31749 4 438 480.0 0R4:501 Type1 Inactive DFGout 18.374 8.329 BBAminus DFGAsp-rot-in -86.73, 154.01 -129.51, 54.97 190.41, 20.02 -106.79, 23.78 305.4, 154.78 -69.14, 128.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -74.68, -58.46 77.98, 6.43 none-out-out SNCnoo out-out ActLoopNT-out 16.065 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -97.72, 139.0 APE9-dihe-na 109.04, 163.38 APE8-dihe-in -97.01, 108.52 APE8-rot-in 315.65 APE67-dihe-in -57.15, -23.24 -58.45, -30.75 APE12-dist-out 14.955 APE11-dist-in 13.395 APE10-dist-out 8.158 APE9-dist-out 6.501 E114A,E115A,E116A None None XRAY 2.19 0.239 0.276 A 446 376 18 0 0 5 [[150, 408]] 1.0 4ejn AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 5KCVA P31749 6 438 480.0 6S1:501 Allosteric Inactive DFGout 18.399 8.593 None DFGAsp-rot-in -66.09, 150.37 -131.74, 48.39 184.7, 23.48 -109.26, 34.53 301.12, 163.72 -73.63, 124.84 none-none none 999.0 Saltbr-none 999.0 HRD-in -80.28, -36.69 71.61, -16.44 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.9, -11.63 999.0, -43.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.7 0.213 0.269 A 460 353 33 0 0 16 [[150, 408]] 1.0 5kcv AGC_AKT1_HUMAN AGC 5.8e-99 336.5 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7APJA P31749 3 439 480.0 No_ligand No_ligand Inactive DFGout 15.36 7.847 None DFGAsp-rot-in -119.51, 172.58 -151.35, 78.25 190.04, -53.34 -78.82, 999.0 276.7, 1.08 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.58, -35.61 73.77, -41.9 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.92 APE8-rot-out 58.45 APE67-dihe-in -70.85, -7.62 -68.6, -17.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S2N None None XRAY 2.05 0.213 0.252 A 440 376 39 0 0 18 [[150, 408]] 1.0 7apj AGC_AKT1_HUMAN AGC 5.1e-99 336.8 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 9ZBKE P31749 141 478 480.0 A1AID:60501 Allosteric Inactive None 999.0 999.0 None DFGAsp-rot-none 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 11.253 Saltbr-none 999.0 HRD-in -67.7524, -46.6734 56.3218, 34.3821 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na -132.6992, 152.6969 APE9-dihe-na 123.2104, 166.6906 APE8-dihe-in -67.0804, 139.7382 APE8-rot-none 999.0 APE67-dihe-in -65.3208, -39.3845 -60.5271, -33.4993 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.954 S473C None None EM 2.6 999.0 999.0 E 338 278 18 0 0 16 [[150, 408]] 1.0 9zbk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHFA P31749 3 439 480.0 G4K:501 Allosteric Inactive None 999.0 8.943 None DFGAsp-rot-in -81.4, 157.14 -136.1, 63.0 178.0, 34.23 -116.97, 21.98 304.54, 147.84 -76.24, 135.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -42.11 68.98, -10.23 none-out-out SNCnoo out-out ActLoopNT-out 16.026 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.64 APE8-rot-out 65.96 APE67-dihe-in -73.6, -35.94 -67.69, -4.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 E114A,E115A,E116A None None XRAY 2.9 0.233 0.274 A 446 366 32 0 0 14 [[150, 408]] 1.0 6hhf AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHGA P31749 3 444 480.0 G4T:501 Allosteric Inactive None 999.0 9.861 None DFGAsp-rot-in -89.51, 153.73 -128.41, 67.53 180.93, 27.61 -114.64, 10.8 307.59, 150.55 -85.41, 154.74 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.28, -46.2 67.11, -14.18 none-out-out SNCnoo out-out ActLoopNT-out 15.289 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.85, 97.08 APE9-dihe-na 87.64, -165.9 APE8-dihe-in -105.98, 137.43 APE8-rot-out 58.9 APE67-dihe-in -57.38, -21.16 -89.5, -4.41 APE12-dist-out 17.366 APE11-dist-out 16.179 APE10-dist-out 10.888 APE9-dist-out 11.447 E114A,E115A,E116A None None XRAY 2.3 0.212 0.246 A 446 386 21 0 0 3 [[150, 408]] 1.0 6hhg AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6HHIA P31749 3 444 480.0 G4N:501 Allosteric Inactive None 999.0 9.394 None DFGAsp-rot-in -89.1, 165.97 -135.32, 55.99 179.51, 29.6 -110.01, 13.3 309.82, 146.72 -70.54, 150.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.6, -44.24 72.4, -22.65 none-out-out SNCnoo out-out ActLoopNT-out 15.413 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -105.21, 101.21 APE9-dihe-na 81.98, -162.79 APE8-dihe-in -113.39, 139.7 APE8-rot-out 66.27 APE67-dihe-in -49.46, -24.76 -86.47, -13.4 APE12-dist-out 17.097 APE11-dist-out 15.773 APE10-dist-out 10.853 APE9-dist-out 11.014 E114A,E115A,E116A None None XRAY 2.7 0.229 0.258 A 446 389 19 0 0 3 [[150, 408]] 1.0 6hhi AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 6S9XA P31749 3 443 480.0 L1W:501 Allosteric Inactive None 999.0 9.471 None DFGAsp-rot-in -83.65, 171.5 -148.58, 59.04 178.53, 24.75 -110.35, 19.84 309.98, 147.1 -81.71, 151.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.64, -44.34 67.14, 2.45 none-out-out SNCnoo out-out ActLoopNT-out 15.655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.24, 142.43 APE9-dihe-na 73.42, -170.52 APE8-dihe-in -106.82, 110.63 APE8-rot-out 60.31 APE67-dihe-in -66.32, -9.87 -76.1, -5.54 APE12-dist-none 999.0 APE11-dist-out 16.242 APE10-dist-out 10.715 APE9-dist-out 10.287 E114A,E115A,E116A None None XRAY 2.6 0.214 0.234 A 446 382 23 0 0 7 [[150, 408]] 1.0 6s9x AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7NH4A P31749 4 444 480.0 UCE:501 Allosteric Inactive None 999.0 9.714 None DFGAsp-rot-in -89.66, 161.99 -134.99, 53.83 172.53, 43.18 -102.41, 15.77 307.61, 150.23 -85.21, 156.95 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.71, -43.96 65.0, -1.87 none-out-out SNCnoo out-out ActLoopNT-out 15.71 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.29, 122.41 APE9-dihe-na 62.81, -158.06 APE8-dihe-in -116.84, 141.55 APE8-rot-out 65.03 APE67-dihe-in -52.37, -30.57 -89.05, -2.1 APE12-dist-out 16.82 APE11-dist-out 16.123 APE10-dist-out 10.705 APE9-dist-out 11.149 E114A,E115A,E116A None None XRAY 2.3 0.224 0.246 A 446 383 24 0 0 6 [[150, 408]] 1.0 7nh4 AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7NH5A P31749 3 444 480.0 UC8:502 Allosteric Inactive None 999.0 9.683 None DFGAsp-rot-in -94.24, 161.49 -131.31, 59.8 179.73, 24.33 -111.8, 8.17 304.51, 156.46 -83.9, 163.26 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.19, -47.43 76.17, -13.35 none-out-out SNCnoo out-out ActLoopNT-out 15.616 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -89.96, 112.26 APE9-dihe-na 68.59, -149.12 APE8-dihe-in -121.33, 137.31 APE8-rot-in 284.5 APE67-dihe-in -57.38, -14.67 -81.19, -19.07 APE12-dist-none 999.0 APE11-dist-out 15.973 APE10-dist-out 10.445 APE9-dist-out 11.434 E114A,E115A,E116A None None XRAY 1.9 0.201 0.228 A 446 383 24 0 0 7 [[150, 408]] 1.0 7nh5 AGC_AKT1_HUMAN AGC 5.3e-99 336.6 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.734 BLAminus DFGAsp-rot-in -120.8, -176.05 56.87, 82.9 186.65, 12.61 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.749 Saltbr-in 2.796 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.193 APE11-dist-in 11.759 APE10-dist-in 6.119 APE9-dist-in 3.921 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336 318 0 0 0 0 [[152, 409]] 1.0 1o6k AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.258 12.925 BLAminus DFGAsp-rot-in -121.53, -178.18 58.41, 83.34 187.36, 7.04 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.794 Saltbr-in 2.76 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.173 APE11-dist-in 11.74 APE10-dist-in 6.122 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337 312 0 0 0 0 [[152, 409]] 1.0 1o6l AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN AF-P31751-K1A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 6.233 13.023 BLAminus DFGAsp-rot-in -113.23, -144.19 8.44, 78.9 204.72, 12.07 -80.27, 18.08 299.23, 85.15 -63.04, -27.98 in-in in 8.759 Saltbr-in 2.638 HRD-in -78.66, -46.08 65.41, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 154.65 APE9-dihe-na 130.96, 174.62 APE8-dihe-in -79.56, 129.32 APE8-rot-in 301.13 APE67-dihe-in -71.15, -16.28 -47.49, -43.65 APE12-dist-in 8.406 APE11-dist-in 11.677 APE10-dist-in 5.92 APE9-dist-in 3.689 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[152, 409]] 1.0 AF-P31751-K1 AGC_AKT2_HUMAN AGC 8.7e-100 339.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN AF-P31751-K3A P31751 144 417 481.0 No_ligand No_ligand Active DFGin 5.926 12.937 BLAminus DFGAsp-rot-in -120.75, -176.12 46.87, 67.81 209.49, 9.39 -72.56, 16.67 304.47, 92.86 -64.84, -25.38 in-in in 8.908 Saltbr-in 2.672 HRD-in -85.04, -45.39 68.23, 12.02 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.84, 152.71 APE9-dihe-na 130.61, 173.68 APE8-dihe-in -78.91, 130.99 APE8-rot-in 284.27 APE67-dihe-in -69.37, -17.14 -47.07, -44.67 APE12-dist-in 8.543 APE11-dist-in 11.658 APE10-dist-in 5.979 APE9-dist-in 3.74 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[152, 409]] 1.0 AF-P31751-K3 AGC_AKT2_HUMAN AGC 8.7e-100 339.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E87A P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.356 13.341 BLAminus DFGAsp-rot-in -126.04, 163.87 68.85, 90.68 210.97, -37.83 -105.7, 33.53 302.5, 89.72 -71.05, -31.02 in-in in 9.195 Saltbr-in 2.673 HRD-in -74.63, -46.2 65.87, 9.52 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 164.29 APE9-dihe-na 138.82, -139.79 APE8-dihe-in -129.72, 130.9 APE8-rot-in 295.88 APE67-dihe-in -69.5, -20.74 -43.13, -48.06 APE12-dist-in 8.258 APE11-dist-in 11.703 APE10-dist-in 6.114 APE9-dist-in 3.669 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 A 335 323 0 0 0 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E87B P31751 146 480 481.0 G95:1 Type1 Active DFGin 6.363 13.328 BLAminus DFGAsp-rot-in -125.6, 164.26 67.65, 91.39 209.66, -39.85 -106.11, 33.4 302.92, 90.11 -70.63, -30.74 in-in in 9.207 Saltbr-in 2.657 HRD-in -73.89, -47.28 67.09, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 163.8 APE9-dihe-na 138.15, -140.19 APE8-dihe-in -128.95, 131.51 APE8-rot-in 293.83 APE67-dihe-in -69.92, -20.28 -43.71, -47.61 APE12-dist-in 8.266 APE11-dist-in 11.706 APE10-dist-in 6.115 APE9-dist-in 3.664 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.3 0.226 0.246 B 335 323 0 0 0 0 [[152, 409]] 1.0 3e87 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2JDOA P31751 146 477 481.0 I5S:61480 Type1 Inactive DFGin 6.491 13.275 BLAminus DFGAsp-rot-out -127.4, 177.55 60.46, 72.21 292.16, 76.26 -91.22, 6.75 299.11, 106.21 -60.04, -25.16 in-in in 8.833 Saltbr-in 2.507 HRD-in -79.9, -47.34 72.69, -4.25 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.18, 166.21 APE9-dihe-na 136.64, -140.86 APE8-dihe-in -130.22, 129.82 APE8-rot-in 295.69 APE67-dihe-in -66.14, -22.16 -45.88, -48.65 APE12-dist-in 8.136 APE11-dist-in 11.57 APE10-dist-in 6.03 APE9-dist-in 3.771 None TPO309 TPO309 XRAY 1.8 0.177 0.21 A 342 312 0 0 0 0 [[152, 409]] 1.0 2jdo AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2JDRA P31751 146 477 481.0 L20:61480 Type1 Active DFGin 6.289 13.187 BLAminus DFGAsp-rot-in -140.76, 154.56 67.85, 87.58 196.94, -1.01 -95.95, 16.78 295.18, 71.62 -47.79, -46.7 in-in in 8.713 Saltbr-in 2.796 HRD-in -80.08, -42.59 66.93, 0.59 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.84, 174.01 APE9-dihe-na 115.68, -166.42 APE8-dihe-in -112.23, 130.56 APE8-rot-in 296.59 APE67-dihe-in -62.74, -25.12 -49.6, -46.59 APE12-dist-in 7.942 APE11-dist-in 11.57 APE10-dist-in 6.023 APE9-dist-in 3.773 None TPO309 TPO309 XRAY 2.3 0.196 0.252 A 342 312 0 0 0 0 [[152, 409]] 1.0 2jdr AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2UW9A P31751 146 477 481.0 GVP:61480 Type1 Inactive DFGin 6.692 13.488 BLAminus DFGAsp-rot-out -123.19, 167.76 65.45, 89.41 275.69, 30.11 -103.32, 13.56 294.7, 84.5 -64.67, -30.65 in-in in 8.915 Saltbr-in 3.485 HRD-in -78.9, -54.33 80.74, -7.46 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.24, 166.16 APE9-dihe-na 136.4, -140.08 APE8-dihe-in -134.83, 122.5 APE8-rot-in 314.64 APE67-dihe-in -71.56, -23.74 -40.7, -46.8 APE12-dist-in 8.171 APE11-dist-in 11.428 APE10-dist-in 5.907 APE9-dist-in 3.877 None TPO309 TPO309 XRAY 2.1 0.226 0.305 A 342 312 0 0 0 0 [[152, 409]] 1.0 2uw9 AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2X39A P31751 146 477 481.0 X39:61480 Type1 Inactive DFGin 6.609 13.163 BLAminus DFGAsp-rot-out -126.64, 166.41 70.83, 82.9 293.15, -23.2 -98.53, 13.96 297.41, 90.75 -64.85, -22.35 in-in in 8.537 Saltbr-in 2.767 HRD-in -80.41, -44.67 68.55, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.85, 165.7 APE9-dihe-na 131.55, -143.54 APE8-dihe-in -129.03, 132.57 APE8-rot-in 295.12 APE67-dihe-in -72.21, -20.28 -47.28, -46.05 APE12-dist-in 8.176 APE11-dist-in 11.519 APE10-dist-in 5.988 APE9-dist-in 3.808 None TPO309 TPO309 XRAY 1.93 0.169 0.226 A 342 312 0 0 0 0 [[152, 409]] 1.0 2x39 AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 2XH5A P31751 146 479 481.0 X37:1480 Type1 Inactive DFGin 6.505 13.551 BLAminus DFGAsp-rot-out -110.05, 164.58 66.53, 108.72 291.65, -79.81 -126.32, 14.52 299.02, 81.83 -57.37, -39.56 in-in in 8.942 Saltbr-in 2.907 HRD-in -77.83, -38.9 65.4, 4.31 in-in-in SNCiii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 176.38 APE9-dihe-na 101.87, -144.62 APE8-dihe-in -126.41, 124.09 APE8-rot-in 301.05 APE67-dihe-in -65.29, -29.42 -46.82, -46.71 APE12-dist-in 8.287 APE11-dist-in 11.609 APE10-dist-in 6.03 APE9-dist-in 3.796 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W TPO309 TPO309 XRAY 2.72 0.216 0.305 A 342 317 0 0 0 0 [[152, 409]] 1.0 2xh5 AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3D0EA P31751 146 480 481.0 G93:1 Type1.5_Back Active DFGin 6.701 13.546 BLAminus DFGAsp-rot-in -125.73, 168.9 61.89, 84.21 205.68, -19.09 -95.51, 25.74 292.33, 79.73 -76.94, 1.71 in-in in 9.061 Saltbr-in 2.764 HRD-in -80.14, -42.28 68.95, -5.28 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.97, 167.33 APE9-dihe-na 127.67, -168.31 APE8-dihe-in -106.36, 125.11 APE8-rot-in 301.0 APE67-dihe-in -64.27, -20.07 -41.91, -50.48 APE12-dist-in 8.248 APE11-dist-in 11.661 APE10-dist-in 6.05 APE9-dist-in 4.016 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 A 335 324 0 0 0 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3D0EB P31751 146 480 481.0 G93:2 Type1.5_Back Active DFGin 6.809 13.565 BLAminus DFGAsp-rot-in -120.57, 168.95 62.61, 83.67 201.77, -13.94 -96.74, 28.63 294.15, 77.27 -76.08, -2.14 in-in in 9.13 Saltbr-in 2.993 HRD-in -78.43, -43.98 69.1, -0.1 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.44, 163.97 APE9-dihe-na 132.51, -165.35 APE8-dihe-in -107.37, 125.67 APE8-rot-in 301.69 APE67-dihe-in -66.88, -18.51 -42.11, -48.84 APE12-dist-in 8.237 APE11-dist-in 11.68 APE10-dist-in 6.04 APE9-dist-in 3.86 None TPO309,TPO451 TPO309,TPO451 XRAY 2.0 0.208 0.246 B 335 324 0 0 0 0 [[152, 409]] 1.0 3d0e AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E88A P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.577 13.405 BLAminus DFGAsp-rot-in -128.82, 173.63 61.99, 93.97 183.23, 13.27 -108.84, 31.73 297.8, 80.14 -73.82, -16.27 in-in in 9.196 Saltbr-in 2.832 HRD-in -75.09, -42.0 67.98, -2.73 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.37, 168.63 APE9-dihe-na 135.96, -142.36 APE8-dihe-in -130.12, 129.82 APE8-rot-in 291.65 APE67-dihe-in -63.55, -20.99 -45.06, -54.18 APE12-dist-in 8.073 APE11-dist-in 11.634 APE10-dist-in 6.003 APE9-dist-in 3.845 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 A 335 321 0 0 0 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E88B P31751 146 480 481.0 G96:1 Type1.5_Back Active DFGin 6.509 13.327 BLAminus DFGAsp-rot-in -128.8, 173.14 62.13, 94.09 183.56, 26.77 -108.62, 31.59 298.9, 80.14 -73.92, -15.88 in-in in 9.208 Saltbr-in 2.724 HRD-in -75.96, -42.03 68.35, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.45, 168.65 APE9-dihe-na 136.37, -142.41 APE8-dihe-in -130.19, 130.02 APE8-rot-in 291.1 APE67-dihe-in -63.44, -20.2 -45.4, -53.85 APE12-dist-in 8.063 APE11-dist-in 11.626 APE10-dist-in 6.004 APE9-dist-in 3.853 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.5 0.232 0.273 B 335 321 0 0 0 0 [[152, 409]] 1.0 3e88 AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E8DA P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.627 13.602 BLAminus DFGAsp-rot-in -131.95, 161.19 63.93, 96.17 189.53, 2.68 -108.94, 28.77 296.25, 77.68 -84.56, 5.75 in-in in 9.2 Saltbr-in 2.805 HRD-in -77.32, -43.78 69.76, 5.0 in-in-in SNCiii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.79, 164.59 APE9-dihe-na 136.0, -148.3 APE8-dihe-in -124.36, 129.64 APE8-rot-in 293.72 APE67-dihe-in -64.33, -19.25 -43.26, -53.33 APE12-dist-in 8.087 APE11-dist-in 11.665 APE10-dist-in 5.995 APE9-dist-in 3.689 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 A 335 316 0 0 0 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 3E8DB P31751 146 480 481.0 G98:1 Type1.5_Back Active DFGin 6.588 13.557 BLAminus DFGAsp-rot-in -130.8, 161.71 64.68, 95.04 189.0, 27.58 -108.93, 28.35 296.53, 82.54 -84.83, 6.03 in-in in 9.239 Saltbr-in 2.851 HRD-in -77.39, -43.59 70.5, 3.48 in-in-in SNCiii in-in ActLoopNT-in 3.079 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.5, 165.61 APE9-dihe-na 135.83, -147.81 APE8-dihe-in -124.63, 129.91 APE8-rot-in 295.04 APE67-dihe-in -64.9, -18.78 -43.89, -52.5 APE12-dist-in 8.082 APE11-dist-in 11.649 APE10-dist-in 5.988 APE9-dist-in 3.707 S474D TPO309,TPO451 TPO309,TPO451 XRAY 2.7 0.214 0.268 B 335 318 0 0 0 0 [[152, 409]] 1.0 3e8d AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 9C1WA P31751 3 440 481.0 XOO:501 Allosteric Inactive DFGout 19.216 8.694 BBAminus DFGAsp-rot-in -83.52, 155.45 -120.63, 49.83 180.88, 26.05 -105.5, 7.82 304.69, 159.06 -62.82, 151.74 out-out out 13.662 Saltbr-out 13.212 HRD-in -78.89, -48.84 68.68, 2.96 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -152.67 APE8-dihe-in -117.72, 106.37 APE8-rot-out 64.01 APE67-dihe-in -60.58, -16.49 -68.37, -26.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.726 P115A,G116A None None XRAY 2.0 0.207 0.242 A 446 388 19 0 0 14 [[152, 409]] 1.0 9c1w AGC_AKT2_HUMAN AGC 4.2e-99 336.9 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 8Q61A P31751 1 435 481.0 K06:60501 Type3 Inactive DFGout 18.89 8.016 BBAminus DFGAsp-rot-in -86.01, 164.11 -136.51, 53.07 188.04, 23.44 -106.57, 16.06 303.39, 155.45 -59.47, 122.51 out-out out 16.663 Saltbr-out 14.734 HRD-in -73.93, -39.6 78.27, -25.65 out-out-none SNCoon out-none ActLoopNT-out 15.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -88.87, 132.41 999.0, 120.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N2D None None XRAY 2.32 0.212 0.263 A 483 382 13 0 0 6 [[152, 409]] 1.0 8q61 AGC_AKT2_HUMAN AGC 5.3e-99 336.6 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZKA P31751 146 441 481.0 No_ligand No_ligand Inactive DFGout 12.879 7.508 None DFGAsp-rot-in -88.28, 169.77 -121.29, 63.03 209.15, -49.65 159.26, 151.54 56.46, 80.21 -112.21, 146.16 in-none in 8.972 Saltbr-none 999.0 HRD-in -76.88, -35.25 63.45, -21.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.79 APE8-rot-out 55.76 APE67-dihe-out -75.52, 140.15 -78.96, 137.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.248 0.319 A 315 271 25 0 0 16 [[152, 409]] 1.0 1gzk AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZOA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.457 7.551 None DFGAsp-rot-in -89.05, 165.48 -112.0, 63.41 192.55, -45.31 173.4, 174.77 48.32, 79.0 -110.82, 136.89 in-none in 8.982 Saltbr-none 999.0 HRD-in -58.12, -43.89 72.65, -26.96 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.94 APE8-rot-out 52.4 APE67-dihe-out -68.85, 138.24 -64.09, 126.63 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.248 0.31 A 315 272 25 0 0 16 [[152, 409]] 1.0 1gzo AGC_AKT2_HUMAN AGC 1.4e-99 338.4 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZNA P31751 146 442 481.0 No_ligand No_ligand Inactive DFGout 13.061 7.207 None DFGAsp-rot-in -86.08, 145.09 -87.68, 45.88 200.91, -44.08 -175.89, 163.19 41.36, 87.18 -86.05, 112.83 in-none in 8.467 Saltbr-none 999.0 HRD-in -65.46, -39.14 69.44, -32.45 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.06 APE8-rot-out 45.36 APE67-dihe-out -66.55, 140.26 -68.72, 127.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.268 0.319 A 335 272 25 0 0 16 [[152, 409]] 1.0 1gzn AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1MRVA P31751 147 440 481.0 No_ligand No_ligand Inactive DFGout 12.598 7.907 None DFGAsp-rot-in -100.04, 151.93 -107.39, 54.86 200.3, -56.88 -100.48, 999.0 298.45, 163.68 999.0, 999.0 none-none none 999.0 Saltbr-none 999.0 HRD-in -61.99, -43.37 76.14, -22.13 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -73.0, 124.68 999.0, 121.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.247 0.295 A 339 261 33 0 0 19 [[152, 409]] 1.0 1mrv AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1MRYA P31751 146 440 481.0 No_ligand No_ligand Inactive DFGout 12.756 7.989 None DFGAsp-rot-in -121.34, 168.73 -126.98, 50.44 184.91, -1.58 -103.46, -121.56 310.73, 158.04 172.34, 79.61 none-none none 999.0 Saltbr-none 999.0 HRD-in -73.55, -34.24 66.17, -25.77 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnio APE10-dihe-na 999.0, 178.93 APE9-dihe-na -93.7, 48.0 APE8-dihe-in -94.52, 126.11 APE8-rot-out 162.32 APE67-dihe-out -83.28, 134.12 -46.1, 120.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.484 APE9-dist-out 16.49 None None None XRAY 2.8 0.227 0.272 A 339 270 25 0 0 13 [[152, 409]] 1.0 1mry AGC_AKT2_HUMAN AGC 1.9e-99 338.0 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT3 AKT3_HUMAN AF-Q9Y243-K1A Q9Y243 140 413 479.0 No_ligand No_ligand Active DFGin 6.38 13.153 BLAminus DFGAsp-rot-in -112.11, -161.48 27.98, 82.03 205.73, 6.48 -85.83, 20.1 298.55, 83.88 -63.73, -28.06 in-in in 8.721 Saltbr-in 2.623 HRD-in -77.1, -50.07 65.87, 7.19 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 152.33 APE9-dihe-na 131.97, 174.69 APE8-dihe-in -79.42, 129.32 APE8-rot-in 300.62 APE67-dihe-in -71.2, -15.34 -47.33, -44.09 APE12-dist-in 8.737 APE11-dist-in 11.659 APE10-dist-in 5.928 APE9-dist-in 3.64 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[148, 405]] 1.0 AF-Q9Y243-K1 AGC_AKT3_HUMAN AGC 2.6e-101 344.1 1 260 260 288 289 290 292 294 177 196 200 268 270 269 271 328 316 311 310 309 308 307 306 305 226 RAC-gamma serine/threonine-protein kinase
AGC AKT3 AKT3_HUMAN AF-Q9Y243-K3A Q9Y243 140 413 479.0 No_ligand No_ligand Active DFGin 5.843 12.845 BLAminus DFGAsp-rot-in -119.93, -165.91 45.76, 60.08 208.14, 19.6 -68.89, 21.59 306.78, 94.29 -64.68, -32.82 in-in in 8.8 Saltbr-in 2.682 HRD-in -85.27, -50.05 69.08, 5.0 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.19, 155.79 APE9-dihe-na 139.4, -174.29 APE8-dihe-in -95.13, 130.97 APE8-rot-in 296.55 APE67-dihe-in -70.47, -15.66 -48.46, -45.34 APE12-dist-in 8.309 APE11-dist-in 11.671 APE10-dist-in 6.004 APE9-dist-in 3.653 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[148, 405]] 1.0 AF-Q9Y243-K3 AGC_AKT3_HUMAN AGC 2.6e-101 344.1 1 260 260 288 289 290 292 294 177 196 200 268 270 269 271 328 316 311 310 309 308 307 306 305 226 RAC-gamma serine/threonine-protein kinase
AGC CDC42BPA MRCKA_HUMAN AF-Q5VT25-K1A Q5VT25 69 351 1732.0 No_ligand No_ligand Active DFGin 6.627 14.085 BLAminus DFGAsp-rot-in -137.35, 178.83 52.57, 60.69 202.87, 23.81 -74.75, 17.34 293.19, 92.14 -61.72, -19.0 in-in in 8.934 Saltbr-in 2.688 HRD-in -76.44, -46.24 68.08, 6.85 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.21, 130.01 APE9-dihe-na 139.4, 177.82 APE8-dihe-in -74.18, 124.45 APE8-rot-in 302.09 APE67-dihe-in -66.75, -21.22 -50.16, -45.25 APE12-dist-in 10.239 APE11-dist-in 11.032 APE10-dist-in 5.325 APE9-dist-in 3.918 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[77, 343]] 1.0 AF-Q5VT25-K1 AGC_CDC42BPA_HUMAN AGC 1.1e-96 328.9 1 260 260 218 219 220 222 224 106 125 129 198 200 199 201 264 247 242 241 240 239 238 237 236 155 Serine/threonine-protein kinase MRCK alpha
AGC CDC42BPA MRCKA_HUMAN AF-Q5VT25-K3A Q5VT25 69 351 1732.0 No_ligand No_ligand Active DFGin 6.089 13.554 BLAminus DFGAsp-rot-in -140.55, 172.62 55.82, 69.24 200.22, 6.66 -78.39, 15.33 299.05, 91.36 -61.53, -17.02 in-in in 8.555 Saltbr-in 2.635 HRD-in -79.96, -45.49 66.46, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.67, 146.01 APE9-dihe-na 127.4, 168.74 APE8-dihe-in -72.01, 132.81 APE8-rot-in 288.27 APE67-dihe-in -76.54, -19.12 -51.84, -40.74 APE12-dist-in 9.879 APE11-dist-in 11.252 APE10-dist-in 5.425 APE9-dist-in 3.544 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[77, 343]] 1.0 AF-Q5VT25-K3 AGC_CDC42BPA_HUMAN AGC 1.1e-96 328.9 1 260 260 218 219 220 222 224 106 125 129 198 200 199 201 264 247 242 241 240 239 238 237 236 155 Serine/threonine-protein kinase MRCK alpha
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.536 13.389 BLAminus DFGAsp-rot-in -126.67, 169.91 71.43, 81.15 187.26, 6.44 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.635 Saltbr-in 2.748 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.511 APE11-dist-in 11.151 APE10-dist-in 6.313 APE9-dist-in 3.548 None None None XRAY 1.73 0.198 0.243 A 419 401 0 0 0 0 [[76, 342]] 1.0 4uak AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN AF-Q9Y5S2-K1A Q9Y5S2 68 350 1711.0 No_ligand No_ligand Active DFGin 6.286 13.418 BLAminus DFGAsp-rot-in -138.11, 175.86 52.03, 73.16 198.2, 19.2 -82.88, 16.9 300.82, 95.68 -61.27, -18.14 in-in in 8.67 Saltbr-in 2.619 HRD-in -80.82, -44.33 65.35, 6.41 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.32, 151.0 APE9-dihe-na 118.31, 170.33 APE8-dihe-in -66.77, 129.62 APE8-rot-in 287.64 APE67-dihe-in -77.39, -20.44 -51.73, -36.54 APE12-dist-in 9.843 APE11-dist-in 10.942 APE10-dist-in 5.188 APE9-dist-in 3.788 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[76, 342]] 1.0 AF-Q9Y5S2-K1 AGC_CDC42BPB_HUMAN AGC 1.8e-96 328.2 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN AF-Q9Y5S2-K3A Q9Y5S2 68 350 1711.0 No_ligand No_ligand Active DFGin 6.165 13.252 BLAminus DFGAsp-rot-in -140.87, 174.27 54.93, 67.41 202.11, 11.11 -77.14, 15.47 302.2, 109.63 -60.94, -17.3 in-in in 8.594 Saltbr-in 2.681 HRD-in -80.0, -45.38 64.95, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.11, 160.14 APE9-dihe-na 106.26, -177.58 APE8-dihe-in -89.7, 125.56 APE8-rot-in 303.52 APE67-dihe-in -69.05, -20.8 -47.75, -44.36 APE12-dist-in 9.53 APE11-dist-in 10.952 APE10-dist-in 5.151 APE9-dist-in 3.627 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[76, 342]] 1.0 AF-Q9Y5S2-K3 AGC_CDC42BPB_HUMAN AGC 1.8e-96 328.2 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3QFVA Q9Y5S2 2 415 1711.0 NM7:416 Type1 Active DFGin 6.652 13.483 BLAminus DFGAsp-rot-in -155.19, -177.74 51.28, 74.91 210.1, 7.48 -100.44, 20.96 290.95, 120.41 -84.8, 1.24 in-in in 8.66 Saltbr-in 3.586 HRD-in -68.56, -55.63 80.26, 2.79 in-in-in SNCiii in-in ActLoopNT-in 3.062 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.25, 145.57 APE9-dihe-na 95.66, -174.68 APE8-dihe-in -88.83, 133.9 APE8-rot-in 320.1 APE67-dihe-in -63.11, -25.9 -60.21, -35.51 APE12-dist-in 10.616 APE11-dist-in 11.198 APE10-dist-in 5.501 APE9-dist-in 4.17 None None None XRAY 2.65 0.196 0.268 A 415 395 0 0 0 0 [[76, 342]] 1.0 3qfv AGC_CDC42BPB_HUMAN AGC 6.6e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3QFVB Q9Y5S2 2 415 1711.0 NM7:416 Type1 Active DFGin 6.357 13.248 BLAminus DFGAsp-rot-in -146.98, -178.33 51.23, 77.88 197.04, -79.76 -102.57, 32.33 302.88, 111.63 -92.77, 5.32 in-in in 8.692 Saltbr-in 2.619 HRD-in -65.12, -52.57 79.81, -7.22 in-in-in SNCiii in-in ActLoopNT-in 3.139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.96, 150.13 APE9-dihe-na 114.47, 164.94 APE8-dihe-in -66.67, 141.54 APE8-rot-in 317.58 APE67-dihe-in -60.07, -38.36 -60.72, -35.72 APE12-dist-in 10.736 APE11-dist-in 11.342 APE10-dist-in 5.667 APE9-dist-in 4.087 None None None XRAY 2.65 0.196 0.268 B 415 396 0 0 0 0 [[76, 342]] 1.0 3qfv AGC_CDC42BPB_HUMAN AGC 6.6e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 4UALA Q9Y5S2 2 417 1711.0 3FV:60501 Type1 Active DFGin 6.57 13.343 BLAminus DFGAsp-rot-in -128.09, 170.47 58.99, 78.49 204.14, -10.96 -90.49, 11.57 302.61, 102.02 -65.54, -5.61 in-in in 8.675 Saltbr-in 2.909 HRD-in -76.1, -52.24 74.17, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.7, -165.94 APE9-dihe-na 97.69, -165.3 APE8-dihe-in -123.13, 127.49 APE8-rot-in 312.99 APE67-dihe-in -64.7, -21.04 -49.2, -41.29 APE12-dist-in 10.401 APE11-dist-in 10.706 APE10-dist-in 5.458 APE9-dist-in 3.725 None None None XRAY 1.71 0.206 0.236 A 419 400 5 0 0 3 [[76, 342]] 1.0 4ual AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 5OTEA Q9Y5S2 2 417 1711.0 AQE:60501 Type1 Active DFGin 6.44 13.538 BLAminus DFGAsp-rot-in -132.86, 172.8 58.15, 78.6 203.24, -11.81 -89.88, 11.87 305.96, 106.7 -64.89, -6.52 in-in in 8.637 Saltbr-in 2.717 HRD-in -76.88, -48.31 73.79, 2.14 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 152.67 APE9-dihe-na 86.33, -167.63 APE8-dihe-in -120.1, 130.3 APE8-rot-in 304.26 APE67-dihe-in -60.96, -19.55 -48.3, -43.83 APE12-dist-in 10.442 APE11-dist-in 11.319 APE10-dist-in 6.425 APE9-dist-in 3.469 None None None XRAY 1.68 0.197 0.218 A 419 404 2 0 0 0 [[76, 342]] 1.0 5ote AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 5OTFA Q9Y5S2 2 417 1711.0 AQ5:60504 Type1 Active DFGin 6.474 13.836 BLAminus DFGAsp-rot-in -138.71, 166.8 56.15, 77.62 201.3, -13.37 -87.94, 13.12 305.59, 108.27 -63.54, -12.28 in-in in 8.966 Saltbr-in 2.633 HRD-in -69.74, -49.73 69.82, 11.73 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.82, 174.96 APE9-dihe-na 90.86, 165.77 APE8-dihe-in -78.76, 136.08 APE8-rot-in 311.34 APE67-dihe-in -61.08, -29.98 -51.0, -40.22 APE12-dist-in 10.501 APE11-dist-in 10.889 APE10-dist-in 5.774 APE9-dist-in 4.003 None None None XRAY 2.0 0.201 0.227 A 419 408 0 0 0 0 [[76, 342]] 1.0 5otf AGC_CDC42BPB_HUMAN AGC 6.7e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUA Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.602 13.355 BLAminus DFGAsp-rot-in -143.03, 175.94 52.02, 80.01 192.66, 1.52 -94.23, 18.83 305.33, 99.72 -66.85, -0.48 in-in in 8.858 Saltbr-in 2.916 HRD-in -68.08, -55.01 75.95, 5.48 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.43, 163.82 APE9-dihe-na 93.99, -165.51 APE8-dihe-in -114.48, 131.1 APE8-rot-in 310.89 APE67-dihe-in -54.25, -25.55 -45.59, -49.4 APE12-dist-in 11.04 APE11-dist-in 11.04 APE10-dist-in 5.176 APE9-dist-in 3.762 None None None XRAY 2.15 0.223 0.273 A 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.4e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPB MRCKB_HUMAN 3TKUB Q9Y5S2 2 415 1711.0 M77:418,M77:419 Type1,Allosteric Active DFGin 6.7 13.42 BLAminus DFGAsp-rot-in -146.47, 178.95 50.88, 78.82 194.59, -4.77 -93.25, 17.64 304.13, 100.62 -66.46, -1.59 in-in in 8.934 Saltbr-in 2.849 HRD-in -79.08, -52.56 75.39, 5.44 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.41, 166.49 APE9-dihe-na 89.07, -163.52 APE8-dihe-in -118.0, 134.6 APE8-rot-in 310.18 APE67-dihe-in -54.07, -25.9 -51.37, -47.08 APE12-dist-in 11.06 APE11-dist-in 11.053 APE10-dist-in 5.192 APE9-dist-in 3.746 None None None XRAY 2.15 0.223 0.273 B 433 395 0 0 0 0 [[76, 342]] 1.0 3tku AGC_CDC42BPB_HUMAN AGC 7.4e-96 326.3 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC CDC42BPG MRCKG_HUMAN AF-Q6DT37-K1A Q6DT37 63 345 1551.0 No_ligand No_ligand Active DFGin 6.249 13.354 BLAminus DFGAsp-rot-in -136.58, 177.62 52.53, 69.39 199.75, 21.61 -81.79, 17.47 304.78, 93.89 -60.65, -18.57 in-in in 8.764 Saltbr-in 2.697 HRD-in -74.8, -49.36 68.64, -0.64 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.03, 134.36 APE9-dihe-na 135.63, 174.09 APE8-dihe-in -75.39, 129.12 APE8-rot-in 303.67 APE67-dihe-in -74.05, -21.28 -51.4, -41.32 APE12-dist-in 10.059 APE11-dist-in 11.03 APE10-dist-in 5.264 APE9-dist-in 3.729 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[71, 337]] 1.0 AF-Q6DT37-K1 AGC_CDC42BPG_HUMAN AGC 1.8e-91 311.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 258 241 236 235 234 233 232 231 230 149 Serine/threonine-protein kinase MRCK gamma
AGC CDC42BPG MRCKG_HUMAN AF-Q6DT37-K3A Q6DT37 63 345 1551.0 No_ligand No_ligand Active DFGin 6.052 13.3 BLAminus DFGAsp-rot-in -141.28, 172.37 53.37, 66.71 201.85, 7.05 -75.24, 16.17 303.15, 98.83 -61.17, -19.77 in-in in 8.565 Saltbr-in 2.619 HRD-in -82.2, -47.68 64.54, 7.21 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 148.94 APE9-dihe-na 121.6, 174.29 APE8-dihe-in -71.61, 132.51 APE8-rot-in 297.13 APE67-dihe-in -71.85, -16.71 -50.64, -43.7 APE12-dist-in 9.674 APE11-dist-in 10.915 APE10-dist-in 5.186 APE9-dist-in 3.564 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[71, 337]] 1.0 AF-Q6DT37-K3 AGC_CDC42BPG_HUMAN AGC 1.8e-91 311.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 258 241 236 235 234 233 232 231 230 149 Serine/threonine-protein kinase MRCK gamma
AGC CIT CTRO_HUMAN AF-O14578-K1A O14578 89 368 2027.0 No_ligand No_ligand Active DFGin 6.409 13.254 BLAminus DFGAsp-rot-in -133.75, 176.99 59.92, 65.89 197.73, 24.84 -78.38, 15.69 305.38, 98.39 -62.22, -18.89 in-in in 8.488 Saltbr-in 2.652 HRD-in -75.88, -45.79 66.97, 8.94 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.7, 139.89 APE9-dihe-na 127.55, 176.62 APE8-dihe-in -71.67, 127.44 APE8-rot-in 288.09 APE67-dihe-in -73.05, -16.96 -48.85, -41.55 APE12-dist-in 11.105 APE11-dist-in 11.223 APE10-dist-in 5.522 APE9-dist-in 3.54 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[97, 360]] 1.0 AF-O14578-K1 AGC_CIT_HUMAN AGC 9e-83 283.3 1 260 260 238 239 240 242 244 126 145 149 218 220 219 221 285 267 262 261 260 259 258 257 256 175 Citron Rho-interacting kinase
AGC CIT CTRO_HUMAN AF-O14578-K3A O14578 89 368 2027.0 No_ligand No_ligand Active DFGin 6.268 13.112 BLAminus DFGAsp-rot-in -131.84, 178.95 60.29, 59.62 201.21, 19.96 -70.63, 9.42 310.34, 101.74 -63.63, -17.83 in-in in 8.165 Saltbr-in 2.667 HRD-in -75.16, -46.66 70.27, -11.82 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.71, 138.84 APE9-dihe-na 132.93, -179.42 APE8-dihe-in -87.72, 130.21 APE8-rot-in 296.39 APE67-dihe-in -71.65, -18.6 -46.94, -44.88 APE12-dist-in 11.406 APE11-dist-in 11.753 APE10-dist-in 5.946 APE9-dist-in 3.113 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[97, 360]] 1.0 AF-O14578-K3 AGC_CIT_HUMAN AGC 9e-83 283.3 1 260 260 238 239 240 242 244 126 145 149 218 220 219 221 285 267 262 261 260 259 258 257 256 175 Citron Rho-interacting kinase
AGC DMPK DMPK_HUMAN AF-Q09013-K1A Q09013 63 347 629.0 No_ligand No_ligand Active DFGin 6.346 13.852 BLAminus DFGAsp-rot-in -137.62, 177.74 53.65, 65.13 199.56, 22.08 -77.89, 17.17 296.72, 90.52 -60.73, -21.33 in-in in 8.815 Saltbr-in 2.648 HRD-in -80.23, -48.51 67.35, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 128.58 APE9-dihe-na 140.09, 174.97 APE8-dihe-in -73.76, 126.81 APE8-rot-in 301.78 APE67-dihe-in -67.58, -20.1 -48.89, -47.46 APE12-dist-in 10.002 APE11-dist-in 10.994 APE10-dist-in 5.275 APE9-dist-in 3.818 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[71, 339]] 1.0 AF-Q09013-K1 AGC_DMPK_HUMAN AGC 6.1e-90 306.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN AF-Q09013-K3A Q09013 63 347 629.0 No_ligand No_ligand Active DFGin 6.28 13.587 BLAminus DFGAsp-rot-in -138.65, -179.6 53.91, 53.19 203.19, 21.93 -69.94, 14.2 301.64, 92.66 -62.49, -16.23 in-in in 8.767 Saltbr-in 2.74 HRD-in -83.91, -45.62 68.98, 2.73 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.36, 130.62 APE9-dihe-na 136.22, 175.22 APE8-dihe-in -79.62, 130.97 APE8-rot-in 297.38 APE67-dihe-in -72.32, -21.96 -47.71, -46.74 APE12-dist-in 10.104 APE11-dist-in 11.131 APE10-dist-in 5.319 APE9-dist-in 3.399 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[71, 339]] 1.0 AF-Q09013-K3 AGC_DMPK_HUMAN AGC 6.1e-90 306.8 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5A Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.454 13.714 BLAminus DFGAsp-rot-in -135.51, 173.02 64.16, 82.57 202.64, -19.0 -103.69, 18.13 299.09, 90.62 -77.9, 10.3 in-in in 8.8 Saltbr-in 2.505 HRD-in -77.17, -55.14 72.28, 14.55 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.26, 159.56 APE9-dihe-na 91.29, 143.9 APE8-dihe-in -51.98, 129.25 APE8-rot-in 309.4 APE67-dihe-in -62.16, -18.51 -40.32, -51.73 APE12-dist-in 10.917 APE11-dist-in 10.832 APE10-dist-in 5.147 APE9-dist-in 3.422 None None None XRAY 2.8 0.198 0.244 A 412 390 4 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5B Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.584 14.066 BLAminus DFGAsp-rot-in -121.55, -178.43 55.14, 76.32 200.88, -18.1 -92.54, 18.35 300.48, 94.03 -63.79, -6.57 in-in in 8.838 Saltbr-in 2.497 HRD-in -79.22, -52.08 70.41, 5.71 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.77, 162.62 APE9-dihe-na 96.06, 164.49 APE8-dihe-in -76.33, 130.66 APE8-rot-in 327.06 APE67-dihe-in -66.1, -27.98 -47.72, -38.95 APE12-dist-in 11.28 APE11-dist-in 11.013 APE10-dist-in 5.474 APE9-dist-in 3.936 None None None XRAY 2.8 0.198 0.244 B 412 380 11 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC GRK1 GRK1_HUMAN AF-Q15835-K1A Q15835 182 463 563.0 No_ligand No_ligand Active DFGin 6.287 12.982 BLAminus DFGAsp-rot-in -136.35, -175.46 50.41, 68.56 206.49, 12.29 -84.63, 18.73 288.09, 153.13 -66.15, -19.38 in-in in 8.539 Saltbr-in 2.698 HRD-in -79.0, -46.45 64.22, 3.54 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.64, 146.23 APE9-dihe-na 128.56, 178.92 APE8-dihe-in -91.42, 131.88 APE8-rot-in 297.69 APE67-dihe-inflip 105.02, -24.11 -55.02, 126.46 APE12-dist-in 10.603 APE11-dist-in 11.278 APE10-dist-in 5.539 APE9-dist-in 3.316 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[190, 455]] 1.0 AF-Q15835-K1 AGC_GRK1_HUMAN AGC 4.9e-81 277.6 4 260 257 334 335 336 338 340 219 238 242 314 316 315 317 374 362 357 356 355 354 353 352 351 268 Rhodopsin kinase GRK1
AGC GRK1 GRK1_HUMAN AF-Q15835-K3A Q15835 182 463 563.0 No_ligand No_ligand Active DFGin 6.234 12.673 BLAminus DFGAsp-rot-in -132.6, -178.51 49.86, 63.45 203.93, 1.25 -76.42, 16.89 298.82, 166.43 -67.25, -17.86 in-in in 8.359 Saltbr-in 2.707 HRD-in -85.57, -47.78 70.01, -0.82 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.92, 145.73 APE9-dihe-na 125.2, -163.99 APE8-dihe-in -109.07, 130.14 APE8-rot-in 295.51 APE67-dihe-inflip 103.48, -23.56 -54.31, 127.87 APE12-dist-in 10.526 APE11-dist-in 11.024 APE10-dist-in 5.333 APE9-dist-in 3.034 None None None AF2 -1.0 1.0 1.0 A 282 282 0 0 0 0 [[190, 455]] 1.0 AF-Q15835-K3 AGC_GRK1_HUMAN AGC 4.9e-81 277.6 4 260 257 334 335 336 338 340 219 238 242 314 316 315 317 374 362 357 356 355 354 353 352 351 268 Rhodopsin kinase GRK1
AGC GRK2 ARBK1_HUMAN AF-P25098-K1A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.562 13.067 BLAminus DFGAsp-rot-in -119.78, 178.65 52.56, 73.94 202.12, 24.92 -83.8, 16.08 278.33, 71.82 -60.8, -26.56 in-in in 8.541 Saltbr-in 2.589 HRD-in -80.89, -42.45 65.72, -2.62 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.3, 128.35 APE9-dihe-na 142.96, -178.54 APE8-dihe-in -87.49, 128.15 APE8-rot-in 299.26 APE67-dihe-inflip 86.45, 0.9 -52.52, 136.47 APE12-dist-in 10.234 APE11-dist-in 12.025 APE10-dist-in 6.083 APE9-dist-in 3.29 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P25098-K1 AGC_GRK2_HUMAN AGC 4.8e-78 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN AF-P25098-K3A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.32 12.853 BLAminus DFGAsp-rot-in -125.8, 178.57 52.64, 62.07 205.19, 18.18 -71.89, 17.23 286.12, 88.29 -61.97, -25.79 in-in in 8.526 Saltbr-in 2.55 HRD-in -86.05, -43.82 69.06, 3.02 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.98, 153.8 APE9-dihe-na 127.94, -163.33 APE8-dihe-in -103.05, 123.69 APE8-rot-in 298.01 APE67-dihe-inflip 89.53, 2.54 -53.74, 129.56 APE12-dist-in 9.061 APE11-dist-in 11.855 APE10-dist-in 5.951 APE9-dist-in 3.215 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P25098-K3 AGC_GRK2_HUMAN AGC 4.8e-78 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UVCA P25098 30 536 689.0 8PV:600 Type1 Inactive DFGin 5.646 13.252 BLAminus DFGAsp-rot-out -111.93, -175.1 48.95, 84.95 262.41, 9.63 -96.99, 16.3 272.95, 81.76 -56.56, -35.65 in-in in 8.667 Saltbr-in 2.796 HRD-in -90.5, -43.84 74.99, -18.44 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.43, 134.46 APE9-dihe-na 148.93, -160.88 APE8-dihe-in -114.94, 135.94 APE8-rot-in 305.71 APE67-dihe-in -77.66, 1.58 -57.71, -38.48 APE12-dist-in 10.247 APE11-dist-in 12.027 APE10-dist-in 6.107 APE9-dist-in 3.357 None None None XRAY 2.65 0.217 0.26 A 547 457 0 0 0 0 [[191, 453]] 1.0 5uvc AGC_GRK2_HUMAN AGC 3.8e-77 268.3 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKLA P25098 31 671 689.0 SIX:702 Type1 Active DFGin 5.553 13.455 BLAminus DFGAsp-rot-in -136.15, 162.37 65.35, 90.8 183.32, 22.08 -91.1, 16.16 287.26, 80.35 -44.51, -43.27 in-in in 8.936 Saltbr-in 2.627 HRD-in -76.69, -51.69 80.53, -28.69 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.59, 119.44 APE9-dihe-na 167.03, -154.05 APE8-dihe-in -112.97, 140.97 APE8-rot-in 300.02 APE67-dihe-in -82.52, 9.1 -61.65, -35.94 APE12-dist-in 10.201 APE11-dist-in 11.742 APE10-dist-in 5.843 APE9-dist-in 3.756 S670A None None XRAY 2.15 0.184 0.228 A 642 630 0 0 0 0 [[191, 453]] 1.0 5ukl AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5HE1A P25098 29 668 689.0 ZS2:701 Type1 Inactive DFGin 5.761 13.074 BLAminus DFGAsp-rot-out -136.45, 161.18 63.18, 92.12 286.68, 22.96 -104.97, 24.32 295.58, 61.08 -54.15, -39.68 in-in in 8.63 Saltbr-in 2.965 HRD-in -75.81, -60.39 89.65, -39.71 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.97, 100.73 APE9-dihe-na -165.78, -165.71 APE8-dihe-in -91.06, 127.63 APE8-rot-in 294.03 APE67-dihe-inflip 109.39, -17.56 -55.26, 129.29 APE12-dist-in 10.334 APE11-dist-in 12.132 APE10-dist-in 6.311 APE9-dist-in 3.893 S670A None None XRAY 3.15 0.172 0.25 A 642 618 0 0 0 0 [[191, 453]] 1.0 5he1 AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 6C2YA P25098 30 668 689.0 EJS:701 Type1 Inactive DFGin 5.248 13.131 BLAminus DFGAsp-rot-out -133.84, 169.51 63.67, 85.91 284.79, 31.3 -91.46, 28.99 286.98, 69.09 -62.06, -46.79 in-in in 8.777 Saltbr-in 2.603 HRD-in -71.8, -47.67 74.94, -21.53 in-in-in SNCiii in-in ActLoopNT-in 3.229 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.32, 147.42 APE9-dihe-na 138.79, -162.57 APE8-dihe-in -110.7, 130.32 APE8-rot-in 292.69 APE67-dihe-inflip 102.38, -19.78 -58.44, 136.12 APE12-dist-in 9.574 APE11-dist-in 11.953 APE10-dist-in 5.976 APE9-dist-in 3.453 S670A None None XRAY 2.74 0.247 0.292 A 689 617 2 0 0 0 [[191, 453]] 1.0 6c2y AGC_GRK2_HUMAN AGC 6.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 4MK0A P25098 30 668 689.0 29X:60702 Type1 Active DFGin 5.022 12.557 BLAminus DFGAsp-rot-in -114.3, 159.32 62.47, 95.12 204.08, -37.37 -99.09, 26.84 314.83, 15.76 -55.23, -46.17 in-in in 8.796 Saltbr-in 3.293 HRD-in -74.82, -46.73 65.86, 15.22 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.22, 138.8 APE9-dihe-na 140.75, -169.47 APE8-dihe-in -90.2, 139.3 APE8-rot-in 300.61 APE67-dihe-inflip 101.57, -12.83 -69.61, 140.12 APE12-dist-in 10.215 APE11-dist-in 12.155 APE10-dist-in 6.419 APE9-dist-in 3.225 None None None XRAY 2.4 0.179 0.238 A 640 630 0 0 0 0 [[191, 453]] 1.0 4mk0 AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7K7LA P25098 30 668 689.0 W4D:702 Type1 Active DFGin 5.346 13.407 BLAminus DFGAsp-rot-in -120.75, 157.11 65.86, 85.74 188.79, 17.26 -89.44, 20.76 269.03, 169.7 -63.22, -26.35 in-in in 9.088 Saltbr-in 2.744 HRD-in -83.14, -50.8 72.46, -22.33 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 143.89 APE9-dihe-na 130.34, -178.78 APE8-dihe-in -87.05, 140.86 APE8-rot-in 300.91 APE67-dihe-inflip 101.09, -17.29 -67.82, 137.73 APE12-dist-in 10.803 APE11-dist-in 12.386 APE10-dist-in 6.443 APE9-dist-in 3.667 None None None XRAY 2.539 0.203 0.244 A 640 616 0 0 0 0 [[191, 453]] 1.0 7k7l AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7K7ZA P25098 30 668 689.0 W4G:701 Type1 Active DFGin 5.228 13.261 BLAminus DFGAsp-rot-in -131.21, 159.45 58.45, 84.74 193.09, -42.66 -81.51, 17.96 273.45, 160.93 -49.98, -46.53 in-in in 9.15 Saltbr-in 2.606 HRD-in -69.84, -65.83 82.28, 6.02 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 129.42 APE9-dihe-na 151.42, -156.98 APE8-dihe-in -108.77, 134.07 APE8-rot-in 292.67 APE67-dihe-inflip 104.4, -17.1 -64.98, 131.58 APE12-dist-in 12.686 APE11-dist-in 12.309 APE10-dist-in 6.485 APE9-dist-in 3.28 None None None XRAY 2.606 0.207 0.262 A 640 625 0 0 0 0 [[191, 453]] 1.0 7k7z AGC_GRK2_HUMAN AGC 5.5e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3V5WA P25098 30 668 689.0 8PR:701 Type1 Inactive DFGin 5.157 12.992 BLAminus DFGAsp-rot-out -135.73, 166.74 63.47, 84.47 292.97, 27.85 -90.01, 8.76 284.89, 155.02 -55.83, -32.04 in-in in 8.928 Saltbr-in 2.929 HRD-in -75.87, -48.67 77.13, -26.65 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 132.09 APE9-dihe-na 148.62, -167.37 APE8-dihe-in -102.18, 145.22 APE8-rot-in 303.37 APE67-dihe-in -68.83, -4.06 -70.22, -32.86 APE12-dist-in 10.0 APE11-dist-in 11.861 APE10-dist-in 5.91 APE9-dist-in 3.689 None None None XRAY 2.07 0.196 0.247 A 689 623 0 0 0 0 [[191, 453]] 1.0 3v5w AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 4PNKA P25098 30 668 689.0 KZQ:701 Type1 Active DFGin 5.696 13.31 BLAminus DFGAsp-rot-in -131.92, 150.67 73.23, 94.18 199.64, -36.26 -104.4, 20.24 276.38, 72.07 -49.27, -48.99 in-in in 8.869 Saltbr-in 2.892 HRD-in -75.55, -46.99 79.65, -28.55 in-in-in SNCiii in-in ActLoopNT-in 3.029 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 151.18 APE9-dihe-na 153.42, -170.47 APE8-dihe-in -97.49, 139.43 APE8-rot-in 296.18 APE67-dihe-inflip 99.83, -0.25 -68.24, 133.65 APE12-dist-in 10.11 APE11-dist-in 11.731 APE10-dist-in 5.94 APE9-dist-in 3.597 None None None XRAY 2.56 0.194 0.259 A 689 625 0 0 0 0 [[191, 453]] 1.0 4pnk AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5WG3A P25098 30 668 689.0 AFM:701 Type1 Inactive DFGin 5.251 12.666 BLAminus DFGAsp-rot-out -140.32, 170.95 56.45, 82.96 279.59, 26.64 -87.3, 21.74 311.79, 174.31 -59.6, -38.71 in-in in 8.948 Saltbr-in 2.847 HRD-in -82.02, -43.09 42.08, 25.46 in-in-in SNCiii in-in ActLoopNT-in 3.257 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.78, 131.07 APE9-dihe-na 153.01, -166.14 APE8-dihe-in -107.02, 132.83 APE8-rot-in 302.54 APE67-dihe-inflip 106.87, -20.46 -62.02, 131.15 APE12-dist-in 10.428 APE11-dist-in 11.793 APE10-dist-in 5.902 APE9-dist-in 3.359 None None None XRAY 2.896 0.201 0.248 A 689 618 5 0 0 0 [[191, 453]] 1.0 5wg3 AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5WG4A P25098 31 668 689.0 AFV:701 Type1 Inactive DFGin 5.306 12.691 BLAminus DFGAsp-rot-out -133.5, 178.66 54.05, 81.87 283.02, -9.6 -91.99, 21.58 286.03, 73.35 -64.61, -41.57 in-in in 8.548 Saltbr-in 3.134 HRD-in -85.74, -45.07 68.56, -11.01 in-in-in SNCiii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 129.47 APE9-dihe-na 146.73, -166.55 APE8-dihe-in -108.67, 131.04 APE8-rot-in 299.39 APE67-dihe-inflip 106.48, -11.49 -60.32, 128.85 APE12-dist-in 10.344 APE11-dist-in 11.98 APE10-dist-in 6.143 APE9-dist-in 3.462 None None None XRAY 2.31 0.235 0.279 A 689 621 2 0 0 0 [[191, 453]] 1.0 5wg4 AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5WG5A P25098 30 668 689.0 ZSO:701 Type1 Active DFGin 5.451 13.01 BLAminus DFGAsp-rot-in -128.14, 171.88 56.74, 83.28 192.77, 21.75 -91.88, 32.75 279.7, 68.89 -65.05, -47.67 in-in in 8.625 Saltbr-in 2.651 HRD-in -77.29, -47.13 67.77, -1.76 in-in-in SNCiii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.64, 131.79 APE9-dihe-na 147.8, -171.59 APE8-dihe-in -95.05, 124.52 APE8-rot-in 297.6 APE67-dihe-inflip 97.31, -8.85 -62.05, 143.11 APE12-dist-in 10.491 APE11-dist-in 12.044 APE10-dist-in 6.193 APE9-dist-in 3.392 None None None XRAY 3.1 0.19 0.232 A 689 617 3 0 0 0 [[191, 453]] 1.0 5wg5 AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.407 13.123 BLAminus DFGAsp-rot-in -119.49, 148.71 76.08, 97.29 197.42, -12.71 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.399 Saltbr-in 2.971 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.151 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.922 APE11-dist-in 11.89 APE10-dist-in 5.931 APE9-dist-in 3.549 None None None XRAY 2.7 0.215 0.257 A 547 414 0 0 0 0 [[191, 453]] 1.0 5uuu AGC_GRK2_HUMAN AGC 3.8e-77 268.3 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 5UKKA P25098 30 667 689.0 8DJ:702 Type1.5_Front Inactive DFGin 5.44 12.848 BLAminus DFGAsp-rot-out -148.52, 179.61 57.76, 73.54 251.91, 52.8 -87.98, 8.97 274.06, 69.08 -60.04, -18.89 in-in in 8.271 Saltbr-in 2.669 HRD-in -76.24, -37.94 75.49, -51.75 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.39, 145.94 APE9-dihe-na 143.2, -151.45 APE8-dihe-in -131.14, 141.32 APE8-rot-in 299.97 APE67-dihe-in -67.12, -33.98 -48.24, -30.82 APE12-dist-in 9.635 APE11-dist-in 11.819 APE10-dist-in 5.846 APE9-dist-in 4.157 S670A None None XRAY 2.6 0.224 0.281 A 642 613 0 0 0 0 [[191, 453]] 1.0 5ukk AGC_GRK2_HUMAN AGC 5.5e-77 267.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 6U7CA P25098 30 669 689.0 Q1Y:701 Type1.5_Front Inactive DFGin 5.061 12.454 BLAminus DFGAsp-rot-out -136.54, 170.55 57.52, 81.77 289.0, 20.73 -86.77, 20.22 308.16, 7.53 -58.1, -34.47 in-in in 9.05 Saltbr-in 2.543 HRD-in -72.35, -46.72 70.07, -13.25 in-in-in SNCiii in-in ActLoopNT-in 3.37 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 132.95 APE9-dihe-na 147.35, -168.5 APE8-dihe-in -105.63, 128.22 APE8-rot-in 297.44 APE67-dihe-inflip 124.86, -14.55 -55.92, 113.23 APE12-dist-in 10.206 APE11-dist-in 12.016 APE10-dist-in 6.072 APE9-dist-in 3.485 None None None XRAY 2.44 0.237 0.262 A 689 631 0 0 0 0 [[191, 453]] 1.0 6u7c AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3CIKA P25098 29 669 689.0 No_ligand No_ligand Inactive DFGin 5.2 12.94 None DFGAsp-rot-in -113.38, -84.39 -77.41, 106.5 198.08, -6.38 -85.28, 5.55 272.59, 132.44 -54.41, -34.31 in-in in 8.589 Saltbr-in 2.83 HRD-in -65.15, -43.87 69.81, -16.37 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 126.35 APE9-dihe-na 141.75, -159.25 APE8-dihe-in -111.86, 146.5 APE8-rot-in 310.14 APE67-dihe-in -81.13, 3.2 -68.81, -30.14 APE12-dist-in 10.977 APE11-dist-in 12.073 APE10-dist-in 6.417 APE9-dist-in 3.587 None None None XRAY 2.75 0.208 0.269 A 689 619 0 0 0 0 [[191, 453]] 1.0 3cik AGC_GRK2_HUMAN AGC 6.5e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 7PWDA P25098 27 668 689.0 8DS:701 Type1 Inactive DFGin 5.281 12.959 None DFGAsp-rot-in -103.27, -91.53 -83.38, 120.45 199.9, -58.11 -98.95, 11.01 295.2, 164.91 -62.17, -28.84 in-in in 8.799 Saltbr-in 2.823 HRD-in -68.27, -51.69 76.81, -22.19 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 145.62 APE9-dihe-na 123.25, -162.48 APE8-dihe-in -110.04, 138.42 APE8-rot-in 305.66 APE67-dihe-inflip 98.02, -22.76 -65.28, 137.62 APE12-dist-in 10.312 APE11-dist-in 11.926 APE10-dist-in 6.019 APE9-dist-in 3.365 S670A None None XRAY 2.6 0.192 0.23 A 697 621 0 0 0 0 [[191, 453]] 1.0 7pwd AGC_GRK2_HUMAN AGC 6.6e-77 267.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRWA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.443 12.512 None DFGAsp-rot-in -124.43, -69.99 -70.72, 103.06 213.0, -25.41 -103.15, 18.82 281.61, 154.56 -63.74, -46.79 in-in in 8.907 Saltbr-in 2.621 HRD-in -80.35, -50.37 71.38, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.68, 135.05 APE9-dihe-na 136.51, -178.33 APE8-dihe-in -97.44, 143.34 APE8-rot-in 311.93 APE67-dihe-in -81.84, -17.98 -65.75, -16.48 APE12-dist-in 9.774 APE11-dist-in 11.718 APE10-dist-in 5.763 APE9-dist-in 3.265 None None None XRAY 2.9 0.216 0.265 A 688 618 0 0 0 0 [[191, 453]] 1.0 3krw AGC_GRK2_HUMAN AGC 6.4e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_HUMAN 3KRXA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.419 12.845 None DFGAsp-rot-in -125.39, -77.94 -69.67, 105.65 208.44, -47.48 -105.64, 33.0 281.38, 161.16 -76.22, -41.07 in-in in 9.181 Saltbr-in 2.945 HRD-in -81.43, -47.09 70.32, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.75, 134.45 APE9-dihe-na 144.08, -171.31 APE8-dihe-in -102.11, 138.21 APE8-rot-in 300.04 APE67-dihe-in -91.64, -15.37 -61.65, -13.24 APE12-dist-in 9.264 APE11-dist-in 11.571 APE10-dist-in 5.62 APE9-dist-in 3.278 None None None XRAY 3.1 0.232 0.27 A 688 618 0 0 0 0 [[191, 453]] 1.0 3krx AGC_GRK2_HUMAN AGC 6.4e-77 267.6 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK3 ARBK2_HUMAN AF-P35626-K1A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.389 12.979 BLAminus DFGAsp-rot-in -119.85, -177.05 47.66, 71.7 202.74, 28.68 -81.78, 19.84 282.66, 77.07 -60.27, -30.98 in-in in 8.444 Saltbr-in 2.574 HRD-in -79.78, -43.12 66.85, 1.96 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.85, 154.0 APE9-dihe-na 126.52, 172.74 APE8-dihe-in -77.57, 128.03 APE8-rot-in 302.33 APE67-dihe-inflip 86.21, -2.04 -52.74, 135.57 APE12-dist-in 9.228 APE11-dist-in 12.059 APE10-dist-in 6.147 APE9-dist-in 3.494 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K1 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
AGC GRK3 ARBK2_HUMAN AF-P35626-K3A P35626 183 461 688.0 No_ligand No_ligand Active DFGin 5.337 12.966 BLAminus DFGAsp-rot-in -127.84, 178.42 53.44, 63.01 205.73, 15.61 -72.34, 17.54 287.43, 91.74 -61.73, -26.86 in-in in 8.586 Saltbr-in 2.574 HRD-in -86.58, -43.9 68.67, 3.65 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 153.69 APE9-dihe-na 128.92, -164.53 APE8-dihe-in -101.52, 124.31 APE8-rot-in 298.48 APE67-dihe-inflip 88.79, 1.53 -53.76, 131.32 APE12-dist-in 9.093 APE11-dist-in 11.84 APE10-dist-in 5.923 APE9-dist-in 3.195 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[191, 453]] 1.0 AF-P35626-K3 AGC_GRK3_HUMAN AGC 1e-79 273.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 G protein-coupled receptor kinase 3
AGC GRK4 GRK4_HUMAN 4YHJA P32298 25 525 578.0 AN2:601 ATPlike Active DFGin 6.129 13.374 BLAminus DFGAsp-rot-in -118.16, -176.89 50.04, 69.58 195.65, -12.01 -89.94, 31.88 285.36, 98.48 -66.46, -45.19 in-in in 9.266 Saltbr-in 3.026 HRD-in -63.35, -45.97 74.46, -21.42 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.22, 157.81 APE9-dihe-na 113.97, -154.87 APE8-dihe-in -108.33, 139.74 APE8-rot-in 312.15 APE67-dihe-inflip 104.58, -18.92 -61.34, 124.85 APE12-dist-in 11.453 APE11-dist-in 12.888 APE10-dist-in 6.916 APE9-dist-in 4.145 C563S,C578S None None XRAY 2.6 0.2 0.248 A 584 501 0 0 0 0 [[187, 449]] 1.0 4yhj AGC_GRK4_HUMAN AGC 8.4e-84 286.9 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN 4YHJB P32298 25 527 578.0 AN2:601 ATPlike Inactive DFGin 6.038 13.172 BLAminus DFGAsp-rot-out -128.85, 178.91 61.8, 67.7 266.95, -74.4 -94.52, 28.72 287.39, 101.3 -65.66, -45.87 in-in in 9.016 Saltbr-in 3.179 HRD-in -66.59, -45.54 76.27, -17.2 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.9, 153.12 APE9-dihe-na 125.18, -147.1 APE8-dihe-in -118.5, 134.63 APE8-rot-in 298.66 APE67-dihe-inflip 107.33, -19.99 -54.96, 119.79 APE12-dist-in 11.128 APE11-dist-in 12.752 APE10-dist-in 6.774 APE9-dist-in 3.816 C563S,C578S None None XRAY 2.6 0.2 0.248 B 584 490 0 0 0 0 [[187, 449]] 1.0 4yhj AGC_GRK4_HUMAN AGC 8.4e-84 286.9 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN AF-P32298-K1A P32298 179 457 578.0 No_ligand No_ligand Active DFGin 6.124 12.833 BLAminus DFGAsp-rot-in -120.03, -175.56 45.08, 74.96 204.69, 22.87 -87.72, 22.25 285.66, 73.41 -59.0, -38.27 in-in in 8.768 Saltbr-in 2.66 HRD-in -81.72, -44.96 67.52, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.15, 151.54 APE9-dihe-na 127.86, 174.63 APE8-dihe-in -80.28, 134.89 APE8-rot-in 301.77 APE67-dihe-inflip 97.33, -20.86 -54.78, 131.24 APE12-dist-in 10.479 APE11-dist-in 12.253 APE10-dist-in 6.255 APE9-dist-in 3.575 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[187, 449]] 1.0 AF-P32298-K1 AGC_GRK4_HUMAN AGC 9e-85 289.8 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK4 GRK4_HUMAN AF-P32298-K3A P32298 179 457 578.0 No_ligand No_ligand Active DFGin 6.099 12.768 BLAminus DFGAsp-rot-in -126.56, 178.75 48.35, 61.02 204.87, 23.2 -72.83, 20.71 294.75, 76.46 -64.12, -27.65 in-in in 8.885 Saltbr-in 2.619 HRD-in -85.16, -47.19 67.94, 0.45 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 150.99 APE9-dihe-na 125.92, -171.45 APE8-dihe-in -98.43, 134.52 APE8-rot-in 298.92 APE67-dihe-inflip 98.38, -17.84 -56.69, 129.66 APE12-dist-in 10.2 APE11-dist-in 11.857 APE10-dist-in 5.872 APE9-dist-in 3.235 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[187, 449]] 1.0 AF-P32298-K3 AGC_GRK4_HUMAN AGC 9e-85 289.8 1 260 260 329 330 331 333 335 216 235 239 309 311 310 312 368 356 351 350 349 348 347 346 345 265 G protein-coupled receptor kinase 4
AGC GRK5 GRK5_HUMAN 9CKOA P34947 1 542 590.0 SGV:602 Type1 Inactive DFGin 5.808 12.496 ABAminus DFGAsp-rot-out -119.73, -59.76 -93.86, 94.44 279.62, 1.73 -93.46, 16.21 299.92, 79.42 -62.04, -34.62 in-in in 8.425 Saltbr-in 2.521 HRD-in -104.67, -57.7 74.0, 4.5 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.51, 140.14 APE9-dihe-na 146.41, -176.34 APE8-dihe-in -106.42, 130.54 APE8-rot-in 306.78 APE67-dihe-inflip 81.24, -12.9 -51.64, 146.1 APE12-dist-in 10.452 APE11-dist-in 12.118 APE10-dist-in 6.155 APE9-dist-in 3.717 None None None XRAY 2.8 0.243 0.28 A 598 540 0 0 0 0 [[186, 448]] 1.0 9cko AGC_GRK5_HUMAN AGC 6.1e-84 287.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRKA P34947 25 542 590.0 A1ARA:601 Type1 Inactive DFGin 5.999 12.725 ABAminus DFGAsp-rot-in -113.29, -59.28 -86.52, 97.64 192.35, -24.73 -98.22, 23.89 284.55, 73.36 -66.95, -28.05 in-in in 8.886 Saltbr-in 2.356 HRD-in -84.62, -58.9 74.96, -0.86 in-in-in SNCiii in-in ActLoopNT-in 3.06 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.94, 168.36 APE9-dihe-na 122.17, -155.18 APE8-dihe-in -114.33, 143.85 APE8-rot-in 306.85 APE67-dihe-inflip 94.43, -16.31 -58.15, 132.79 APE12-dist-in 9.666 APE11-dist-in 11.73 APE10-dist-in 6.061 APE9-dist-in 4.128 D311N None None XRAY 2.7 0.223 0.276 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brk AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRLA P34947 25 542 590.0 A1ARB:601 Type1 Inactive DFGin 5.691 12.023 ABAminus DFGAsp-rot-in -103.25, -52.89 -74.4, 160.18 208.06, -29.39 -158.5, 11.72 277.51, 97.57 -69.39, -26.51 in-in in 8.836 Saltbr-in 2.354 HRD-in -84.95, -56.21 70.99, 10.31 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 162.58 APE9-dihe-na 130.63, -156.95 APE8-dihe-in -113.5, 144.35 APE8-rot-in 307.43 APE67-dihe-inflip 83.43, -12.88 -53.97, 135.79 APE12-dist-in 9.714 APE11-dist-in 11.875 APE10-dist-in 6.043 APE9-dist-in 4.223 D311N None None XRAY 2.73 0.231 0.275 A 598 501 0 0 0 0 [[186, 448]] 1.0 9brl AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.253 12.479 ABAminus DFGAsp-rot-in -116.3, -61.02 -91.04, 101.81 179.19, 61.84 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.91 Saltbr-in 3.037 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.932 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brp AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Inactive DFGin 5.282 13.172 BLAminus DFGAsp-rot-out -119.9, 173.82 59.88, 73.64 297.53, 55.8 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.193 Saltbr-in 3.053 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.302 APE11-dist-in 12.056 APE10-dist-in 6.23 APE9-dist-in 4.255 None None None XRAY 1.802 0.174 0.205 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnd AGC_GRK5_HUMAN AGC 1.2e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus DFGAsp-rot-in -123.04, 159.77 67.48, 80.75 208.15, -7.31 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus DFGAsp-rot-in -123.04, 167.6 79.98, 56.79 199.25, -25.13 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN AF-P34947-K1A P34947 178 456 590.0 No_ligand No_ligand Inactive DFGin 5.488 12.674 BLAminus DFGAsp-rot-out -115.97, -177.38 48.25, 67.07 276.27, 4.32 -77.66, 16.16 284.97, 107.27 -63.58, -32.29 in-in in 8.966 Saltbr-in 2.674 HRD-in -81.4, -44.95 66.95, -1.22 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 159.3 APE9-dihe-na 118.39, -174.52 APE8-dihe-in -94.59, 137.57 APE8-rot-in 303.09 APE67-dihe-inflip 95.72, -15.07 -56.34, 127.54 APE12-dist-in 10.505 APE11-dist-in 12.248 APE10-dist-in 6.215 APE9-dist-in 3.781 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K1 AGC_GRK5_HUMAN AGC 6.2e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN AF-P34947-K3A P34947 178 456 590.0 No_ligand No_ligand Active DFGin 6.022 12.099 BLAminus DFGAsp-rot-in -130.04, 178.69 50.56, 62.08 202.36, 7.28 -71.61, 20.06 306.44, 6.94 -60.07, -35.44 in-in in 8.543 Saltbr-in 2.615 HRD-in -88.42, -48.64 68.04, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.09, 156.11 APE9-dihe-na 120.9, -174.14 APE8-dihe-in -94.05, 138.77 APE8-rot-in 297.52 APE67-dihe-inflip 92.74, -12.69 -58.9, 127.55 APE12-dist-in 10.541 APE11-dist-in 11.976 APE10-dist-in 5.961 APE9-dist-in 3.312 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P34947-K3 AGC_GRK5_HUMAN AGC 6.2e-85 290.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKQA P34947 25 542 590.0 No_ligand No_ligand Active DFGin 6.036 12.85 BLAminus DFGAsp-rot-in -128.35, 170.36 62.76, 74.57 191.5, -18.84 -90.62, 17.1 285.99, 91.78 -58.04, -33.82 in-in in 9.106 Saltbr-in 2.933 HRD-in -93.54, -52.56 67.97, 1.13 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.01, 171.06 APE9-dihe-na 118.15, -151.5 APE8-dihe-in -127.65, 146.62 APE8-rot-in 290.59 APE67-dihe-inflip 92.51, -30.74 -57.11, 135.04 APE12-dist-in 9.779 APE11-dist-in 12.023 APE10-dist-in 6.163 APE9-dist-in 4.116 D311N None None XRAY 2.7 0.239 0.294 A 597 490 11 0 0 0 [[186, 448]] 1.0 9ckq AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 4TNBA P34947 15 543 590.0 SGV:601 Type1 Inactive DFGin 5.135 12.74 BLAminus DFGAsp-rot-out -123.5, 176.17 54.54, 74.38 281.14, 3.18 -84.69, 6.5 286.26, 112.63 -51.75, -34.18 in-in in 9.001 Saltbr-in 2.528 HRD-in -77.08, -45.38 66.65, 0.7 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 150.87 APE9-dihe-na 143.24, -163.75 APE8-dihe-in -110.5, 150.66 APE8-rot-in 315.23 APE67-dihe-inflip 90.86, -23.2 -67.3, 136.98 APE12-dist-in 10.739 APE11-dist-in 11.875 APE10-dist-in 5.946 APE9-dist-in 4.112 None None None XRAY 2.113 0.175 0.232 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnb AGC_GRK5_HUMAN AGC 1.2e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAPA P34947 25 542 590.0 W2T:601 Type1 Active DFGin 5.952 12.669 BLAminus DFGAsp-rot-in -132.18, -179.7 52.11, 79.03 188.79, 1.81 -91.08, 7.0 281.21, 78.18 -55.19, -15.59 in-in in 8.933 Saltbr-in 2.319 HRD-in -89.52, -55.99 69.41, 4.8 in-in-in SNCiii in-in ActLoopNT-in 3.075 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.72, 157.14 APE9-dihe-na 134.87, -160.65 APE8-dihe-in -105.62, 143.33 APE8-rot-in 315.67 APE67-dihe-inflip 91.84, -13.85 -56.42, 130.69 APE12-dist-in 10.242 APE11-dist-in 12.329 APE10-dist-in 6.498 APE9-dist-in 4.083 D311N None None XRAY 2.5 0.229 0.267 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uap AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus DFGAsp-rot-in -128.67, 172.15 57.35, 77.75 187.2, 1.77 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRGA P34947 25 542 590.0 A1AQ6:601 Type1 Active DFGin 5.888 12.744 BLAminus DFGAsp-rot-in -127.15, 171.02 61.76, 75.85 189.75, -1.48 -94.14, 20.1 287.82, 78.85 -68.02, -19.4 in-in in 9.043 Saltbr-in 2.346 HRD-in -85.19, -53.81 70.34, 12.77 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.02, 160.56 APE9-dihe-na 125.86, -158.84 APE8-dihe-in -113.45, 141.13 APE8-rot-in 318.14 APE67-dihe-inflip 91.69, -20.41 -53.6, 133.88 APE12-dist-in 9.77 APE11-dist-in 12.073 APE10-dist-in 6.219 APE9-dist-in 4.083 D311N None None XRAY 2.7 0.242 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brg AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRHA P34947 25 542 590.0 A1AQ7:601 Type1 Active DFGin 6.213 12.998 BLAminus DFGAsp-rot-in -137.89, -178.33 53.87, 65.42 189.34, 1.43 -85.04, 16.09 287.04, 75.14 -57.93, -30.07 in-in in 9.364 Saltbr-in 2.788 HRD-in -82.45, -56.04 70.11, 8.28 in-in-in SNCiii in-in ActLoopNT-in 3.099 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.58, 168.01 APE9-dihe-na 127.33, -166.12 APE8-dihe-in -113.88, 147.37 APE8-rot-in 307.37 APE67-dihe-inflip 89.75, -29.49 -53.29, 136.77 APE12-dist-in 10.364 APE11-dist-in 12.068 APE10-dist-in 6.136 APE9-dist-in 4.119 D311N None None XRAY 3.69 0.2 0.244 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brh AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRMA P34947 25 542 590.0 A1ARC:601 Type1 Active DFGin 5.93 12.32 BLAminus DFGAsp-rot-in -129.54, 170.53 64.08, 75.97 187.97, -0.6 -94.87, 21.89 289.68, 68.45 -68.62, -20.59 in-in in 8.627 Saltbr-in 2.58 HRD-in -82.68, -56.6 72.77, 4.07 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.28, 165.33 APE9-dihe-na 123.74, -150.01 APE8-dihe-in -120.92, 138.81 APE8-rot-in 302.36 APE67-dihe-inflip 99.67, -19.1 -52.94, 128.15 APE12-dist-in 9.803 APE11-dist-in 12.059 APE10-dist-in 6.213 APE9-dist-in 4.157 D311N None None XRAY 2.73 0.234 0.278 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brm AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRNA P34947 25 542 590.0 A1ARD:601 Type1 Active DFGin 5.902 12.725 BLAminus DFGAsp-rot-in -139.33, 159.94 74.16, 72.44 193.95, -6.51 -89.41, 22.16 291.23, 67.98 -67.08, -25.78 in-in in 8.993 Saltbr-in 2.439 HRD-in -78.87, -49.6 65.54, 8.73 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.44, 151.94 APE9-dihe-na 136.85, -155.43 APE8-dihe-in -118.42, 144.51 APE8-rot-in 301.29 APE67-dihe-inflip 92.21, -11.38 -55.67, 128.36 APE12-dist-in 9.809 APE11-dist-in 11.996 APE10-dist-in 6.094 APE9-dist-in 4.274 D311N None None XRAY 2.9 0.209 0.256 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brn AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BROA P34947 25 542 590.0 A1ARE:601 Type1 Active DFGin 5.964 12.572 BLAminus DFGAsp-rot-in -128.27, -178.6 50.36, 73.78 190.25, -7.35 -90.4, 21.64 280.73, 75.17 -69.22, -25.34 in-in in 8.906 Saltbr-in 2.39 HRD-in -93.36, -59.82 68.46, 12.12 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.17, 167.74 APE9-dihe-na 123.28, -154.67 APE8-dihe-in -122.1, 138.71 APE8-rot-in 314.65 APE67-dihe-inflip 102.22, -12.34 -51.46, 123.36 APE12-dist-in 10.277 APE11-dist-in 12.337 APE10-dist-in 6.406 APE9-dist-in 4.05 D311N None None XRAY 2.8 0.221 0.271 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bro AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKPA P34947 1 542 590.0 SGV:602 Type1 Active DFGin 5.386 11.98 BLAminus DFGAsp-rot-in -132.87, 164.94 63.45, 71.08 186.35, -6.85 -85.64, 18.91 320.14, 3.39 -67.22, -15.79 in-in in 8.975 Saltbr-in 3.569 HRD-in -105.81, -54.45 67.93, 0.86 in-in-in SNCiii in-in ActLoopNT-in 3.27 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.75, 161.15 APE9-dihe-na 132.47, 178.17 APE8-dihe-in -105.33, 153.16 APE8-rot-in 325.98 APE67-dihe-inflip 78.63, 4.41 -62.29, 127.28 APE12-dist-in 10.034 APE11-dist-in 12.223 APE10-dist-in 6.349 APE9-dist-in 4.192 D311N None None XRAY 2.6 0.236 0.27 A 598 538 0 0 0 0 [[186, 448]] 1.0 9ckp AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9MX2A P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.528 11.483 BLAminus DFGAsp-rot-in -134.92, 166.93 57.12, 70.75 193.49, -22.04 -87.84, 20.9 322.36, 5.46 -68.95, -14.98 in-out in 8.353 Saltbr-out 3.626 HRD-in -110.96, -57.41 68.72, 2.93 out-in-in SNCoii in-in ActLoopNT-in 3.364 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.2, 161.4 APE9-dihe-na 129.58, 177.82 APE8-dihe-in -100.27, 150.38 APE8-rot-in 311.4 APE67-dihe-inflip 86.26, -1.66 -66.59, 129.67 APE12-dist-in 10.155 APE11-dist-in 12.391 APE10-dist-in 6.511 APE9-dist-in 4.173 D311N None None XRAY 3.9 0.284 0.346 A 599 538 0 0 0 0 [[186, 448]] 1.0 9mx2 AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 6PJXA P34947 1 542 590.0 SGV:60601 Type1 Inactive DFGin 5.237 11.877 None DFGAsp-rot-in -101.92, -82.66 -75.73, 114.06 197.36, -75.15 -96.27, 14.0 297.14, 3.15 -60.02, -23.28 in-in in 8.8 Saltbr-in 2.36 HRD-in -81.73, -51.04 76.16, -8.97 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.38, 158.39 APE9-dihe-na 127.63, -164.44 APE8-dihe-in -112.45, 140.59 APE8-rot-in 303.57 APE67-dihe-inflip 81.94, -9.46 -52.3, 137.55 APE12-dist-in 9.846 APE11-dist-in 11.942 APE10-dist-in 6.114 APE9-dist-in 4.464 E104K,R304H,G438E None None XRAY 1.96 0.197 0.23 A 591 542 0 0 0 0 [[186, 448]] 1.0 6pjx AGC_GRK5_HUMAN AGC 1.2e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.02 12.841 None DFGAsp-rot-in -112.48, -65.82 -86.97, 96.33 183.61, 8.28 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.334 Saltbr-in 3.369 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.102 APE10-dist-in 6.306 APE9-dist-in 4.174 D311N None None XRAY 2.8 0.232 0.277 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRFA P34947 25 542 590.0 A1AQ5:601 Type1 Inactive DFGin 6.213 12.885 None DFGAsp-rot-in -116.13, -75.08 -76.38, 97.42 182.19, 0.84 -93.08, 20.96 275.91, 78.29 -67.65, -17.42 in-in in 9.076 Saltbr-in 2.475 HRD-in -89.29, -49.76 68.56, 5.65 in-in-in SNCiii in-in ActLoopNT-in 3.058 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.67, 152.28 APE9-dihe-na 135.63, -159.61 APE8-dihe-in -113.28, 137.14 APE8-rot-in 304.0 APE67-dihe-inflip 86.51, -10.19 -50.9, 134.51 APE12-dist-in 9.984 APE11-dist-in 12.065 APE10-dist-in 6.225 APE9-dist-in 4.119 D311N None None XRAY 2.84 0.224 0.277 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brf AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRIA P34947 25 542 590.0 A1AQ8:601 Type1 Inactive DFGin 5.79 12.714 None DFGAsp-rot-in -118.56, -79.42 -70.93, 91.99 175.52, 50.59 -85.99, 18.72 271.5, 67.77 -66.54, -25.08 in-in in 8.802 Saltbr-in 2.649 HRD-in -85.77, -46.41 67.52, 4.46 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.68, 145.74 APE9-dihe-na 145.19, -146.92 APE8-dihe-in -122.56, 141.77 APE8-rot-in 306.39 APE67-dihe-inflip 92.75, -9.14 -56.37, 130.7 APE12-dist-in 10.133 APE11-dist-in 12.215 APE10-dist-in 6.571 APE9-dist-in 4.225 D311N None None XRAY 2.9 0.217 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bri AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BRJA P34947 25 542 590.0 A1AQ9:601 Type1 Inactive DFGin 5.735 12.619 None DFGAsp-rot-in -115.77, -57.96 -84.12, 93.88 185.59, 3.51 -92.94, 12.58 279.31, 72.41 -59.97, -23.3 in-in in 9.057 Saltbr-in 2.377 HRD-in -83.8, -57.51 72.28, 3.71 in-in-in SNCiii in-in ActLoopNT-in 3.116 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.79, 160.14 APE9-dihe-na 133.68, -150.07 APE8-dihe-in -119.54, 137.2 APE8-rot-in 310.18 APE67-dihe-inflip 98.77, -19.66 -54.34, 129.82 APE12-dist-in 9.723 APE11-dist-in 12.109 APE10-dist-in 6.414 APE9-dist-in 4.167 D311N None None XRAY 2.8 0.239 0.273 A 598 503 0 0 0 0 [[186, 448]] 1.0 9brj AGC_GRK5_HUMAN AGC 7.8e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.207 13.284 BLAminus DFGAsp-rot-in -133.82, 164.79 58.79, 76.03 188.37, 11.14 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.341 Saltbr-in 3.219 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.478 APE11-dist-in 11.834 APE10-dist-in 6.083 APE9-dist-in 3.906 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576 495 0 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.09 13.146 BLAminus DFGAsp-rot-in -128.37, 163.87 55.35, 87.14 186.91, 8.51 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.231 Saltbr-in 2.439 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.477 APE11-dist-in 11.872 APE10-dist-in 6.167 APE9-dist-in 3.71 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576 492 5 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOA P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.423 12.986 BLAminus DFGAsp-rot-in -150.32, 176.66 46.57, 93.99 184.14, 20.15 -112.64, 27.92 269.12, 56.38 -53.19, -36.92 in-in in 8.492 Saltbr-in 3.133 HRD-in -67.42, -53.58 67.41, 17.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.58, 145.08 APE9-dihe-na 153.72, -154.4 APE8-dihe-in -119.63, 125.01 APE8-rot-in 309.24 APE67-dihe-inflip 99.19, -30.43 -48.0, 129.76 APE12-dist-in 10.102 APE11-dist-in 11.881 APE10-dist-in 6.152 APE9-dist-in 3.985 None None None XRAY 2.92 0.222 0.253 A 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYOB P43250 2 557 576.0 AMP:60577 ATPlike Active DFGin 6.469 12.921 BLAminus DFGAsp-rot-in -147.57, -176.88 49.48, 66.09 192.64, 45.89 -89.42, 43.68 283.74, 78.16 -61.9, -48.01 in-in in 8.429 Saltbr-in 2.859 HRD-in -67.89, -44.49 63.77, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 138.67 APE9-dihe-na 143.94, 179.93 APE8-dihe-in -100.37, 135.53 APE8-rot-in 311.67 APE67-dihe-inflip 96.9, -39.59 -38.27, 126.0 APE12-dist-in 10.148 APE11-dist-in 11.731 APE10-dist-in 5.96 APE9-dist-in 3.734 None None None XRAY 2.92 0.222 0.253 B 576 553 3 0 0 0 [[186, 448]] 1.0 3nyo AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN AF-P43250-K1A P43250 178 456 576.0 No_ligand No_ligand Active DFGin 6.216 12.749 BLAminus DFGAsp-rot-in -123.11, -178.58 47.67, 74.06 201.73, 22.12 -87.65, 23.59 291.93, 77.77 -58.68, -35.83 in-in in 8.712 Saltbr-in 2.665 HRD-in -82.84, -44.36 66.32, 2.28 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.32, 157.5 APE9-dihe-na 121.0, 172.74 APE8-dihe-in -78.3, 135.32 APE8-rot-in 301.62 APE67-dihe-inflip 93.32, -20.35 -55.72, 131.85 APE12-dist-in 10.366 APE11-dist-in 12.137 APE10-dist-in 6.139 APE9-dist-in 3.49 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P43250-K1 AGC_GRK6_HUMAN AGC 2.3e-86 295.0 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN AF-P43250-K3A P43250 178 456 576.0 No_ligand No_ligand Active DFGin 6.045 12.282 BLAminus DFGAsp-rot-in -130.79, 178.36 51.08, 64.04 203.4, 6.87 -74.31, 18.83 302.42, 178.07 -60.87, -31.76 in-in in 8.624 Saltbr-in 2.619 HRD-in -87.79, -47.34 67.55, 3.73 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 159.69 APE9-dihe-na 109.39, -175.73 APE8-dihe-in -92.28, 133.79 APE8-rot-in 298.55 APE67-dihe-inflip 96.49, -17.7 -57.25, 129.59 APE12-dist-in 10.525 APE11-dist-in 11.952 APE10-dist-in 5.989 APE9-dist-in 3.192 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[186, 448]] 1.0 AF-P43250-K3 AGC_GRK6_HUMAN AGC 2.3e-86 295.0 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYNA P43250 2 557 576.0 SGV:60577 Type1 Inactive DFGin 6.645 12.68 BLAminus DFGAsp-rot-out -161.03, 177.65 50.76, 84.33 273.92, 24.4 -106.7, 25.79 281.1, 79.92 -51.73, -45.29 in-in in 8.312 Saltbr-in 2.766 HRD-in -85.94, -51.42 62.16, 25.53 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.0, 146.47 APE9-dihe-na 148.26, -154.46 APE8-dihe-in -112.6, 137.1 APE8-rot-in 298.15 APE67-dihe-inflip 129.81, -32.33 -65.27, 111.53 APE12-dist-in 9.947 APE11-dist-in 11.807 APE10-dist-in 6.06 APE9-dist-in 3.657 None None None XRAY 2.72 0.227 0.238 A 576 553 3 0 0 0 [[186, 448]] 1.0 3nyn AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYNB P43250 2 557 576.0 SGV:60577 Type1 Inactive DFGin 6.727 12.824 BLAminus DFGAsp-rot-out -165.39, 175.41 57.11, 63.92 263.22, 46.72 -91.01, 39.72 289.62, 84.65 -64.54, -42.76 in-in in 8.321 Saltbr-in 2.928 HRD-in -79.96, -51.35 60.14, 27.4 in-in-in SNCiii in-in ActLoopNT-in 3.193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.23, 144.63 APE9-dihe-na 148.65, -158.33 APE8-dihe-in -111.02, 128.64 APE8-rot-in 289.73 APE67-dihe-inflip 120.73, -19.06 -60.78, 111.9 APE12-dist-in 10.086 APE11-dist-in 11.778 APE10-dist-in 6.03 APE9-dist-in 3.591 None None None XRAY 2.72 0.227 0.238 B 576 553 3 0 0 0 [[186, 448]] 1.0 3nyn AGC_GRK6_HUMAN AGC 2.1e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK7 GRK7_HUMAN AF-Q8WTQ7-K1A Q8WTQ7 183 462 553.0 No_ligand No_ligand Active DFGin 5.929 12.613 BLAminus DFGAsp-rot-in -133.31, 179.18 49.9, 64.37 204.5, 25.45 -76.28, 16.87 298.16, 175.08 -59.65, -30.13 in-in in 8.672 Saltbr-in 2.652 HRD-in -76.82, -43.16 65.03, -5.02 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.38, 151.36 APE9-dihe-na 130.52, 169.53 APE8-dihe-in -83.21, 132.57 APE8-rot-in 300.08 APE67-dihe-inflip 93.05, -16.2 -55.98, 134.31 APE12-dist-in 9.402 APE11-dist-in 11.255 APE10-dist-in 5.521 APE9-dist-in 3.339 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[191, 454]] 1.0 AF-Q8WTQ7-K1 AGC_GRK7_HUMAN AGC 7.5e-77 263.9 1 260 260 333 334 335 337 339 220 239 243 313 315 314 316 373 360 355 354 353 352 351 350 349 269 Rhodopsin kinase GRK7
AGC GRK7 GRK7_HUMAN AF-Q8WTQ7-K3A Q8WTQ7 183 462 553.0 No_ligand No_ligand Active DFGin 6.049 12.227 BLAminus DFGAsp-rot-in -140.12, -175.95 46.19, 59.72 201.36, 9.33 -72.96, 14.71 305.72, 3.12 -61.03, -26.32 in-in in 8.426 Saltbr-in 2.648 HRD-in -81.75, -42.27 66.36, -4.03 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.45, 154.07 APE9-dihe-na 122.89, 177.55 APE8-dihe-in -94.77, 134.12 APE8-rot-in 298.37 APE67-dihe-inflip 101.79, -16.54 -61.18, 130.51 APE12-dist-in 9.597 APE11-dist-in 11.158 APE10-dist-in 5.385 APE9-dist-in 3.096 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[191, 454]] 1.0 AF-Q8WTQ7-K3 AGC_GRK7_HUMAN AGC 7.5e-77 263.9 1 260 260 333 334 335 337 339 220 239 243 313 315 314 316 373 360 355 354 353 352 351 350 349 269 Rhodopsin kinase GRK7
AGC LATS1 LATS1_HUMAN AF-O95835-K1A O95835 697 1018 1130.0 No_ligand No_ligand Active DFGin 6.448 13.636 BLAminus DFGAsp-rot-in -143.35, 177.8 55.65, 59.96 198.83, 24.33 -76.33, 19.85 303.31, 93.61 -60.54, -23.3 in-in in 8.715 Saltbr-in 2.589 HRD-in -76.01, -44.62 64.86, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, 152.9 APE9-dihe-na 115.97, 164.18 APE8-dihe-in -69.17, 126.81 APE8-rot-in 291.41 APE67-dihe-in -73.93, -24.48 -53.79, -30.18 APE12-dist-in 8.378 APE11-dist-in 11.6 APE10-dist-in 5.68 APE9-dist-in 4.0 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[705, 1010]] 1.0 AF-O95835-K1 AGC_LATS1_HUMAN AGC 6e-99 336.3 1 260 260 845 846 847 849 851 734 753 757 825 827 826 828 932 920 915 914 913 912 911 910 909 783 Serine/threonine-protein kinase LATS1
AGC LATS1 LATS1_HUMAN AF-O95835-K3A O95835 697 1018 1130.0 No_ligand No_ligand Active DFGin 6.258 13.477 BLAminus DFGAsp-rot-in -141.89, 179.41 57.95, 56.46 204.61, 21.82 -67.19, 12.5 305.54, 96.31 -65.12, -18.55 in-in in 8.603 Saltbr-in 2.598 HRD-in -72.7, -50.58 67.96, -2.1 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.44, 160.32 APE9-dihe-na 110.94, 162.86 APE8-dihe-in -79.18, 131.32 APE8-rot-in 297.15 APE67-dihe-in -76.19, -23.32 -55.25, -28.73 APE12-dist-in 8.616 APE11-dist-in 11.521 APE10-dist-in 5.689 APE9-dist-in 3.222 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[705, 1010]] 1.0 AF-O95835-K3 AGC_LATS1_HUMAN AGC 6e-99 336.3 1 260 260 845 846 847 849 851 734 753 757 825 827 826 828 932 920 915 914 913 912 911 910 909 783 Serine/threonine-protein kinase LATS1
AGC LATS2 LATS2_HUMAN AF-Q9NRM7-K1A Q9NRM7 660 981 1088.0 No_ligand No_ligand Active DFGin 6.524 13.733 BLAminus DFGAsp-rot-in -135.12, -176.38 50.42, 56.34 205.74, 26.89 -69.48, 13.51 299.9, 82.84 -67.51, -8.19 in-in in 8.828 Saltbr-in 2.61 HRD-in -75.89, -48.73 67.39, 3.63 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.49, 167.28 APE9-dihe-na 102.76, 163.55 APE8-dihe-in -82.71, 133.67 APE8-rot-in 300.06 APE67-dihe-in -76.79, -28.01 -54.69, -30.21 APE12-dist-in 8.514 APE11-dist-in 11.63 APE10-dist-in 5.753 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[668, 973]] 1.0 AF-Q9NRM7-K1 AGC_LATS2_HUMAN AGC 1.2e-99 338.6 1 260 260 808 809 810 812 814 697 716 720 788 790 789 791 895 883 878 877 876 875 874 873 872 746 Serine/threonine-protein kinase LATS2
AGC LATS2 LATS2_HUMAN AF-Q9NRM7-K3A Q9NRM7 660 981 1088.0 No_ligand No_ligand Active DFGin 6.107 13.541 BLAminus DFGAsp-rot-in -140.84, -177.37 57.32, 57.14 202.07, 20.36 -69.85, 9.28 305.0, 103.31 -63.54, -18.57 in-in in 8.623 Saltbr-in 2.628 HRD-in -73.99, -51.28 68.37, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.94, 158.65 APE9-dihe-na 113.61, 162.45 APE8-dihe-in -79.33, 131.36 APE8-rot-in 297.59 APE67-dihe-in -73.0, -25.22 -54.12, -32.61 APE12-dist-in 8.591 APE11-dist-in 11.606 APE10-dist-in 5.771 APE9-dist-in 3.222 None None None AF2 -1.0 1.0 1.0 A 322 322 0 0 0 0 [[668, 973]] 1.0 AF-Q9NRM7-K3 AGC_LATS2_HUMAN AGC 1.2e-99 338.6 1 260 260 808 809 810 812 814 697 716 720 788 790 789 791 895 883 878 877 876 875 874 873 872 746 Serine/threonine-protein kinase LATS2
AGC MAST1 MAST1_HUMAN AF-Q9Y2H9-K1A Q9Y2H9 366 655 1570.0 No_ligand No_ligand Active DFGin 6.618 13.248 BLAminus DFGAsp-rot-in -138.58, -179.67 61.91, 62.13 204.55, 14.92 -75.14, 16.43 307.86, 107.52 -58.73, -26.5 in-in in 8.571 Saltbr-in 2.666 HRD-in -71.62, -49.4 68.88, -11.12 in-in-in SNCiii in-in ActLoopNT-in 2.964 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.19, 150.52 APE9-dihe-na 122.98, 175.51 APE8-dihe-in -83.39, 115.94 APE8-rot-in 306.22 APE67-dihe-in -66.34, -22.78 -46.59, -39.59 APE12-dist-in 11.831 APE11-dist-in 12.441 APE10-dist-in 6.64 APE9-dist-in 4.145 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[374, 647]] 1.0 AF-Q9Y2H9-K1 AGC_MAST1_HUMAN AGC 6.3e-97 329.7 1 260 260 514 515 516 518 520 403 422 426 494 496 495 497 569 557 552 551 550 549 548 547 546 452 Microtubule-associated serine/threonine-protein kinase 1
AGC MAST1 MAST1_HUMAN AF-Q9Y2H9-K3A Q9Y2H9 366 655 1570.0 No_ligand No_ligand Active DFGin 6.179 13.387 BLAminus DFGAsp-rot-in -139.34, -179.61 56.59, 78.0 202.65, 4.73 -84.65, 19.65 302.87, 97.34 -64.99, -20.16 in-in in 8.473 Saltbr-in 2.607 HRD-in -75.61, -48.95 68.43, -6.75 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.99, 146.81 APE9-dihe-na 128.23, 179.36 APE8-dihe-in -77.45, 118.48 APE8-rot-in 290.11 APE67-dihe-in -64.73, -19.93 -48.18, -41.38 APE12-dist-in 11.728 APE11-dist-in 12.091 APE10-dist-in 6.665 APE9-dist-in 4.485 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[374, 647]] 1.0 AF-Q9Y2H9-K3 AGC_MAST1_HUMAN AGC 6.3e-97 329.7 1 260 260 514 515 516 518 520 403 422 426 494 496 495 497 569 557 552 551 550 549 548 547 546 452 Microtubule-associated serine/threonine-protein kinase 1
AGC MAST2 MAST2_HUMAN AF-Q6P0Q8-K1A Q6P0Q8 504 793 1798.0 No_ligand No_ligand Active DFGin 6.411 13.36 BLAminus DFGAsp-rot-in -134.48, 176.64 63.48, 68.04 204.67, 2.63 -78.49, 16.62 307.28, 103.65 -60.72, -22.41 in-in in 8.662 Saltbr-in 2.64 HRD-in -71.43, -51.38 68.67, -7.82 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.91, 149.43 APE9-dihe-na 128.65, -177.44 APE8-dihe-in -86.63, 114.88 APE8-rot-in 306.21 APE67-dihe-in -65.83, -23.52 -47.09, -39.32 APE12-dist-in 12.138 APE11-dist-in 12.568 APE10-dist-in 6.944 APE9-dist-in 4.246 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[512, 785]] 1.0 AF-Q6P0Q8-K1 AGC_MAST2_HUMAN AGC 7e-98 332.8 1 260 260 652 653 654 656 658 541 560 564 632 634 633 635 707 695 690 689 688 687 686 685 684 590 Microtubule-associated serine/threonine-protein kinase 2
AGC MAST2 MAST2_HUMAN AF-Q6P0Q8-K3A Q6P0Q8 504 793 1798.0 No_ligand No_ligand Active DFGin 6.104 13.474 BLAminus DFGAsp-rot-in -140.2, -179.55 56.73, 79.38 203.67, 1.2 -84.63, 19.96 302.1, 96.79 -64.67, -19.66 in-in in 8.476 Saltbr-in 2.603 HRD-in -72.34, -47.12 71.88, -13.41 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.18, 149.37 APE9-dihe-na 125.46, -175.09 APE8-dihe-in -86.05, 115.5 APE8-rot-in 308.38 APE67-dihe-in -64.49, -22.71 -48.28, -41.41 APE12-dist-in 11.856 APE11-dist-in 12.184 APE10-dist-in 6.823 APE9-dist-in 4.643 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[512, 785]] 1.0 AF-Q6P0Q8-K3 AGC_MAST2_HUMAN AGC 7e-98 332.8 1 260 260 652 653 654 656 658 541 560 564 632 634 633 635 707 695 690 689 688 687 686 685 684 590 Microtubule-associated serine/threonine-protein kinase 2
AGC MAST3 MAST3_HUMAN AF-O60307-K1A O60307 359 648 1309.0 No_ligand No_ligand Active DFGin 6.522 13.444 BLAminus DFGAsp-rot-in -138.03, 178.79 62.24, 64.88 204.01, 9.36 -76.46, 17.82 304.34, 93.51 -60.68, -21.95 in-in in 8.441 Saltbr-in 2.596 HRD-in -71.01, -52.26 70.35, -7.1 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.85, 149.66 APE9-dihe-na 122.8, 176.45 APE8-dihe-in -83.11, 114.61 APE8-rot-in 306.68 APE67-dihe-in -65.58, -21.81 -46.47, -40.36 APE12-dist-in 11.762 APE11-dist-in 12.28 APE10-dist-in 6.582 APE9-dist-in 4.246 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[367, 640]] 1.0 AF-O60307-K1 AGC_MAST3_HUMAN AGC 1.4e-98 335.1 1 260 260 507 508 509 511 513 396 415 419 487 489 488 490 562 550 545 544 543 542 541 540 539 445 Microtubule-associated serine/threonine-protein kinase 3
AGC MAST3 MAST3_HUMAN AF-O60307-K3A O60307 359 648 1309.0 No_ligand No_ligand Active DFGin 6.18 13.44 BLAminus DFGAsp-rot-in -138.61, 179.42 58.85, 73.13 203.99, 5.7 -80.23, 17.38 301.73, 96.41 -64.4, -20.11 in-in in 8.487 Saltbr-in 2.617 HRD-in -73.93, -52.53 71.51, -3.81 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.89, 146.32 APE9-dihe-na 130.74, -178.05 APE8-dihe-in -84.77, 114.43 APE8-rot-in 307.72 APE67-dihe-in -65.31, -20.3 -48.45, -40.32 APE12-dist-in 11.628 APE11-dist-in 12.043 APE10-dist-in 6.588 APE9-dist-in 4.482 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[367, 640]] 1.0 AF-O60307-K3 AGC_MAST3_HUMAN AGC 1.4e-98 335.1 1 260 260 507 508 509 511 513 396 415 419 487 489 488 490 562 550 545 544 543 542 541 540 539 445 Microtubule-associated serine/threonine-protein kinase 3
AGC MAST4 MAST4_HUMAN AF-O15021-K1A O15021 562 851 2623.0 No_ligand No_ligand Active DFGin 6.44 13.459 BLAminus DFGAsp-rot-in -137.47, 177.13 60.94, 67.65 205.24, -2.06 -78.32, 16.66 306.06, 103.66 -61.37, -20.77 in-in in 8.622 Saltbr-in 2.607 HRD-in -72.62, -50.14 65.81, 7.35 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.82, 155.64 APE9-dihe-na 121.63, -177.08 APE8-dihe-in -87.04, 117.87 APE8-rot-in 305.8 APE67-dihe-in -65.95, -21.55 -46.81, -39.91 APE12-dist-in 10.092 APE11-dist-in 12.316 APE10-dist-in 6.615 APE9-dist-in 3.944 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[570, 843]] 1.0 AF-O15021-K1 AGC_MAST4_HUMAN AGC 4.8e-98 333.3 1 260 260 710 711 712 714 716 599 618 622 690 692 691 693 765 753 748 747 746 745 744 743 742 648 Microtubule-associated serine/threonine-protein kinase 4
AGC MAST4 MAST4_HUMAN AF-O15021-K3A O15021 562 851 2623.0 No_ligand No_ligand Active DFGin 6.237 13.537 BLAminus DFGAsp-rot-in -139.76, -179.31 59.32, 69.49 204.87, 4.42 -78.15, 16.78 302.9, 94.69 -64.85, -19.65 in-in in 8.563 Saltbr-in 2.646 HRD-in -73.74, -50.47 69.74, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.96, 155.78 APE9-dihe-na 123.92, -173.73 APE8-dihe-in -85.8, 119.22 APE8-rot-in 305.81 APE67-dihe-in -64.26, -20.07 -48.25, -42.01 APE12-dist-in 9.202 APE11-dist-in 11.969 APE10-dist-in 6.548 APE9-dist-in 4.0 None None None AF2 -1.0 1.0 1.0 A 290 290 0 0 0 0 [[570, 843]] 1.0 AF-O15021-K3 AGC_MAST4_HUMAN AGC 4.8e-98 333.3 1 260 260 710 711 712 714 716 599 618 622 690 692 691 693 765 753 748 747 746 745 744 743 742 648 Microtubule-associated serine/threonine-protein kinase 4
AGC MASTL GWL_HUMAN AF-Q96GX5-K1A Q96GX5 27 843 879.0 No_ligand No_ligand Active DFGin 6.511 14.249 BLAminus DFGAsp-rot-in -136.98, 175.5 52.45, 59.28 206.14, 9.37 -63.96, 15.13 300.56, 93.34 -53.91, -47.49 in-in in 8.776 Saltbr-in 2.642 HRD-in -73.64, -43.72 60.71, -18.09 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.26, 121.64 APE9-dihe-na 143.48, 174.34 APE8-dihe-in -74.8, 126.47 APE8-rot-in 296.06 APE67-dihe-in -71.28, -23.69 -46.57, -43.27 APE12-dist-in 11.456 APE11-dist-in 12.048 APE10-dist-in 6.356 APE9-dist-in 5.035 None None None AF2 -1.0 1.0 1.0 A 817 817 0 0 0 0 [[35, 835]] 1.0 AF-Q96GX5-K1 AGC_MASTL_HUMAN AGC 9.5e-130 437.3 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 748 743 742 741 740 739 738 737 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN AF-Q96GX5-K3A Q96GX5 27 843 879.0 No_ligand No_ligand Active DFGin 5.887 14.65 BLAminus DFGAsp-rot-in -143.15, -179.72 55.04, 67.18 203.9, 0.69 -81.13, 21.34 288.66, 83.06 -63.08, -28.24 in-in in 8.238 Saltbr-in 2.67 HRD-in -73.76, -46.46 67.61, -17.09 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.57, 127.46 APE9-dihe-na 155.7, -179.82 APE8-dihe-in -89.49, 123.19 APE8-rot-in 308.85 APE67-dihe-in -65.53, -23.25 -48.82, -46.12 APE12-dist-in 11.356 APE11-dist-in 11.666 APE10-dist-in 6.303 APE9-dist-in 5.128 None None None AF2 -1.0 1.0 1.0 A 817 817 0 0 0 0 [[35, 835]] 1.0 AF-Q96GX5-K3 AGC_MASTL_HUMAN AGC 9.5e-130 437.3 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 748 743 742 741 740 739 738 737 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 8V5HA Q96GX5 29 847 879.0 A1AAE:901 Type1 Inactive DFGin 5.085 13.223 BLAminus DFGAsp-rot-in -135.18, 177.58 58.63, 62.34 209.42, 29.24 -71.68, 109.75 297.2, 74.01 -104.29, 55.4 in-out in 8.521 Saltbr-out 4.333 HRD-in -78.07, -52.76 71.88, -16.08 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 128.94 APE9-dihe-na -93.04, -154.15 APE8-dihe-in -57.55, 116.33 APE8-rot-in 298.94 APE67-dihe-in -56.59, -15.98 -59.72, -38.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.614 APE9-dist-out 6.232 None None None XRAY 2.74 0.254 0.281 A 343 250 27 0 0 19 [[35, 835]] 1.0 8v5h AGC_MASTL_HUMAN AGC 9.2e-130 437.3 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 748 743 742 741 740 739 738 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHA Q96GX5 30 854 879.0 STU:60901 Type1 Inactive DFGin 10.84 13.519 BLAplus DFGAsp-rot-in -154.04, -179.93 62.84, 37.43 217.13, -76.58 -106.51, -23.39 59.72, 80.58 -168.74, -25.48 none-none none 999.0 Saltbr-none 999.0 HRD-in -59.31, -45.76 66.7, 4.42 none-out-out SNCnoo out-out ActLoopNT-out 8.33 ActLoopCT-out nonTYR APEdihe_aanon APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 165.16 APE8-dihe-none -79.14, 999.0 APE8-rot-out 44.79 APE67-dihe-none -72.42, -27.62 999.0, 33.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.891 None None None XRAY 3.1 0.209 0.265 A 341 246 34 0 0 15 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4.1e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC MASTL GWL_HUMAN 5LOHB Q96GX5 30 854 879.0 STU:60901 Type1 Inactive None 999.0 13.339 None DFGAsp-rot-in -152.85, -174.25 66.27, 69.27 210.57, 88.86 -150.61, -21.46 41.33, 82.81 -90.34, 22.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.11, -44.59 64.53, 4.15 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aannn APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -141.8 APE8-dihe-none -77.31, 999.0 APE8-rot-none 999.0 APE67-dihe-none 49.84, -65.93 999.0, -82.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.713 None None None XRAY 3.1 0.209 0.265 B 341 250 30 0 0 17 [[35, 835]] 1.0 5loh AGC_MASTL_HUMAN AGC 4.1e-131 441.8 1 260 260 173 174 175 177 179 62 81 85 153 155 154 156 760 201 196 195 741 740 -9999 -9999 -9999 111 Serine/threonine-protein kinase greatwall
AGC PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.612 14.931 BLAminus DFGAsp-rot-in -145.26, -169.97 71.92, 72.18 192.2, 20.86 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.581 Saltbr-in 2.71 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.298 APE9-dist-in 3.799 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289 285 4 0 0 4 [[82, 342]] 1.0 1h1w AGC_PDPK1_HUMAN AGC 1e-84 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.619 15.095 BLAminus DFGAsp-rot-in -141.33, -175.84 82.91, 67.67 191.68, 17.83 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.673 Saltbr-in 2.575 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.868 APE11-dist-in 12.869 APE10-dist-in 7.268 APE9-dist-in 4.745 S241A None None XRAY 1.95 0.186 0.23 A 310 288 0 0 0 0 [[82, 342]] 1.0 2biy AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.486 14.833 BLAminus DFGAsp-rot-in -136.91, -178.17 71.81, 74.55 202.23, 18.32 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.421 Saltbr-in 3.159 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.409 APE11-dist-in 10.582 APE10-dist-in 4.926 APE9-dist-in 3.479 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311 280 4 0 0 4 [[82, 342]] 1.0 3hrc AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.548 14.998 BLAminus DFGAsp-rot-in -136.55, -175.99 74.63, 72.8 201.28, 22.14 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.52 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.281 APE11-dist-in 10.502 APE10-dist-in 4.943 APE9-dist-in 3.569 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311 284 0 0 0 0 [[82, 342]] 1.0 4rrv AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Inactive DFGin 6.615 14.861 BLAminus DFGAsp-rot-out -135.34, 179.84 72.22, 79.01 281.2, 35.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.418 Saltbr-in 2.583 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.326 APE11-dist-in 10.522 APE10-dist-in 4.978 APE9-dist-in 3.558 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311 287 0 0 0 0 [[82, 342]] 1.0 5ack AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.303 14.998 BLAminus DFGAsp-rot-in -144.92, -168.82 66.06, 77.78 194.2, -10.21 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.158 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.907 APE11-dist-in 10.671 APE10-dist-in 5.166 APE9-dist-in 3.705 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.328 14.55 BLAminus DFGAsp-rot-in -137.23, -179.71 80.14, 74.16 185.74, 13.47 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.274 Saltbr-in 3.302 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.872 APE11-dist-in 11.011 APE10-dist-in 5.375 APE9-dist-in 3.787 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.391 14.608 BLAminus DFGAsp-rot-in -132.15, -176.81 71.98, 84.02 194.29, 22.96 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.304 Saltbr-in 3.087 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.652 APE11-dist-in 10.863 APE10-dist-in 5.123 APE9-dist-in 3.645 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.334 14.433 BLAminus DFGAsp-rot-in -146.99, -174.22 74.22, 81.56 195.88, 5.87 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.304 Saltbr-in 3.252 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.228 APE11-dist-in 10.891 APE10-dist-in 5.348 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.551 14.867 BLAminus DFGAsp-rot-in -136.23, -174.98 70.54, 70.07 200.1, -11.41 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.252 Saltbr-in 2.643 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.163 APE11-dist-in 10.524 APE10-dist-in 4.979 APE9-dist-in 3.527 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311 280 5 0 0 0 [[82, 342]] 1.0 4ct2 AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.429 14.7 BLAminus DFGAsp-rot-in -133.69, -177.11 74.21, 73.9 195.15, 21.67 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.346 Saltbr-in 2.667 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.352 APE11-dist-in 10.498 APE10-dist-in 4.91 APE9-dist-in 3.542 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310 284 0 0 0 0 [[82, 342]] 1.0 5mrd AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.514 14.784 BLAminus DFGAsp-rot-in -133.77, -176.11 75.25, 77.12 200.44, 30.19 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.387 Saltbr-in 2.701 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.351 APE11-dist-in 10.546 APE10-dist-in 4.867 APE9-dist-in 3.481 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311 285 0 0 0 0 [[82, 342]] 1.0 3hrf AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.512 14.757 BLAminus DFGAsp-rot-in -135.73, -177.17 74.25, 74.67 196.89, 18.2 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.319 Saltbr-in 2.864 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.447 APE10-dist-in 4.873 APE9-dist-in 3.509 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a06 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus DFGAsp-rot-in -134.84, 177.25 78.73, 76.19 221.06, -58.96 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus DFGAsp-rot-in -137.24, -178.23 68.96, 84.69 188.02, 9.8 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.576 Saltbr-in 2.864 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.653 APE11-dist-in 10.852 APE10-dist-in 5.075 APE9-dist-in 3.586 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311 287 5 0 0 5 [[82, 342]] 1.0 4aw1 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.461 14.786 BLAminus DFGAsp-rot-in -139.06, -177.03 75.27, 72.83 204.82, 14.94 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.464 Saltbr-in 2.941 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.244 APE11-dist-in 10.466 APE10-dist-in 4.918 APE9-dist-in 3.544 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311 286 0 0 0 0 [[82, 342]] 1.0 4rqk AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.492 14.954 BLAminus DFGAsp-rot-in -139.41, -174.88 74.87, 69.78 197.41, 11.79 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.256 Saltbr-in 2.772 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.253 APE11-dist-in 10.488 APE10-dist-in 4.969 APE9-dist-in 3.513 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311 289 0 0 0 0 [[82, 342]] 1.0 4rqv AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.005 BLAminus DFGAsp-rot-in -134.78, 179.9 79.12, 70.17 202.31, 18.74 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.588 Saltbr-in 2.631 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.45 APE11-dist-in 10.558 APE10-dist-in 4.984 APE9-dist-in 3.553 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311 287 0 0 0 0 [[82, 342]] 1.0 5lvo AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.602 14.979 BLAminus DFGAsp-rot-in -141.71, -172.51 72.43, 72.08 198.45, 9.85 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.146 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.357 APE11-dist-in 10.489 APE10-dist-in 5.018 APE9-dist-in 3.48 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311 284 0 0 0 0 [[82, 342]] 1.0 4ct1 AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.513 14.988 BLAminus DFGAsp-rot-in -138.47, -176.21 74.83, 73.76 201.91, 22.08 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.442 Saltbr-in 2.922 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.372 APE11-dist-in 10.575 APE10-dist-in 4.947 APE9-dist-in 3.545 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310 289 0 0 0 0 [[82, 342]] 1.0 4xx9 AGC_PDPK1_HUMAN AGC 7e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.655 14.752 BLAminus DFGAsp-rot-in -135.35, -178.9 76.01, 72.4 205.56, 22.7 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.621 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.322 APE11-dist-in 10.427 APE10-dist-in 4.998 APE9-dist-in 3.582 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a07 AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXA O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.596 14.169 BLAminus DFGAsp-rot-in -138.52, -175.65 62.9, 74.02 204.71, 0.57 -93.7, 13.51 275.9, 89.61 -62.84, -23.94 in-in in 8.813 Saltbr-in 2.556 HRD-in -68.79, -51.77 77.65, -2.64 in-in-out SNCiio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.38 APE9-dihe-na -61.01, -163.77 APE8-dihe-in -59.2, 130.87 APE8-rot-in 313.64 APE67-dihe-in -68.86, -21.58 -48.76, -40.32 APE12-dist-in 9.226 APE11-dist-out 5.784 APE10-dist-out 10.531 APE9-dist-in 3.983 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 A 316 284 1 0 0 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXB O15530 77 359 556.0 1F8:1 Allosteric Inactive DFGin 6.66 14.155 BLAminus DFGAsp-rot-in -140.69, -175.67 59.43, 71.11 196.8, 4.06 -92.21, 14.29 279.78, 86.28 -63.72, -16.63 in-in in 8.802 Saltbr-in 2.564 HRD-in -68.32, -50.05 78.21, -3.88 in-in-out SNCiio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.03, 106.62 APE9-dihe-na -60.26, -162.55 APE8-dihe-in -59.71, 131.44 APE8-rot-in 313.93 APE67-dihe-in -67.3, -21.72 -51.61, -39.66 APE12-dist-in 9.238 APE11-dist-out 5.801 APE10-dist-out 10.552 APE9-dist-in 3.908 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 B 316 281 2 0 0 2 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXC O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.63 14.096 BLAminus DFGAsp-rot-in -135.92, -176.39 63.79, 71.64 201.23, -2.02 -93.36, 13.73 280.67, 86.49 -62.67, -20.94 in-in in 8.782 Saltbr-in 2.551 HRD-in -66.06, -52.0 76.42, -2.2 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.22, 106.64 APE9-dihe-na -60.77, -161.89 APE8-dihe-in -59.91, 131.8 APE8-rot-in 311.89 APE67-dihe-in -63.47, -22.82 -49.61, -43.91 APE12-dist-in 9.165 APE11-dist-out 5.801 APE10-dist-out 10.55 APE9-dist-in 3.984 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 C 316 284 1 0 0 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXD O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.571 14.146 BLAminus DFGAsp-rot-in -134.45, -170.09 60.8, 71.91 203.18, -7.14 -91.57, 12.91 278.05, 86.51 -67.5, -17.43 in-in in 8.799 Saltbr-in 2.583 HRD-in -66.01, -50.34 77.25, -1.95 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -110.2, 105.71 APE9-dihe-na -59.39, -160.44 APE8-dihe-in -60.94, 132.03 APE8-rot-in 313.43 APE67-dihe-in -67.95, -22.9 -52.31, -39.76 APE12-dist-in 9.227 APE11-dist-out 5.79 APE10-dist-out 10.547 APE9-dist-in 3.912 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 D 316 283 1 0 0 1 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXE O15530 76 359 556.0 1F8:1 Allosteric Inactive DFGin 6.382 14.921 BLAminus DFGAsp-rot-out -125.38, -158.75 61.49, 56.01 247.66, 59.14 -85.03, 10.36 279.31, 82.03 -55.13, -32.27 in-in in 9.237 Saltbr-in 3.272 HRD-in -67.18, -49.37 73.61, -2.74 in-in-out SNCiio in-out ActLoopNT-in 2.968 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.75, 120.85 APE9-dihe-na -80.18, -170.48 APE8-dihe-in -52.91, 130.32 APE8-rot-in 309.26 APE67-dihe-in -61.57, -27.92 -56.84, -38.07 APE12-dist-none 999.0 APE11-dist-out 5.488 APE10-dist-out 10.269 APE9-dist-in 4.482 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 E 316 274 10 0 0 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXF O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.368 14.915 BLAminus DFGAsp-rot-in -124.96, -165.04 64.25, 56.63 239.54, 65.1 -90.23, 13.81 273.61, 91.31 -58.82, -32.5 in-none in 9.232 Saltbr-none 999.0 HRD-in -66.95, -49.19 76.54, -9.89 none-in-out SNCnio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.23, 117.01 APE9-dihe-na -74.75, -174.06 APE8-dihe-in -40.45, 117.92 APE8-rot-in 309.94 APE67-dihe-in -62.78, -29.13 -41.21, -44.42 APE12-dist-in 8.118 APE11-dist-out 5.489 APE10-dist-out 10.275 APE9-dist-in 4.463 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 F 316 275 10 0 0 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXG O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.418 15.162 BLAminus DFGAsp-rot-out -124.35, -160.11 59.71, 58.4 249.61, 50.18 -85.01, 8.33 270.63, 86.47 -58.24, -35.05 in-in in 9.232 Saltbr-in 3.257 HRD-in -66.57, -49.64 76.01, -6.1 in-in-out SNCiio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.59, 119.71 APE9-dihe-na -80.06, -167.69 APE8-dihe-in -52.92, 132.86 APE8-rot-in 313.01 APE67-dihe-in -62.53, -35.87 -56.69, -38.23 APE12-dist-in 8.493 APE11-dist-out 5.482 APE10-dist-out 10.229 APE9-dist-in 4.361 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 G 316 275 10 0 0 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORXH O15530 75 359 556.0 1F8:1 Allosteric Inactive DFGin 6.47 14.836 BLAminus DFGAsp-rot-out -123.34, -162.32 62.45, 60.25 240.51, 57.85 -89.76, 14.7 283.48, 85.4 -55.85, -32.26 in-in in 9.235 Saltbr-in 3.283 HRD-in -67.42, -48.8 75.62, -9.07 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.9, 122.93 APE9-dihe-na -81.65, -170.32 APE8-dihe-in -53.77, 133.41 APE8-rot-in 303.61 APE67-dihe-in -61.23, -30.63 -57.13, -39.02 APE12-dist-in 8.378 APE11-dist-out 5.496 APE10-dist-out 10.198 APE9-dist-in 4.418 T148C SEP241 SEP241 XRAY 2.204 0.209 0.243 H 316 275 10 0 0 10 [[82, 342]] 1.0 3orx AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 8DQTA O15530 70 359 556.0 U35:401,U35:402,U35:403 Allosteric,Allosteric,Allosteric Active DFGin 6.539 15.228 BLAminus DFGAsp-rot-in -137.99, -177.67 76.39, 75.41 195.07, 13.78 -107.03, 7.63 286.75, 95.91 -68.77, -18.63 in-in in 8.557 Saltbr-in 2.907 HRD-in -74.31, -48.93 74.07, -13.37 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.2, 161.34 APE9-dihe-na 132.87, -165.96 APE8-dihe-in -131.33, 133.45 APE8-rot-in 295.53 APE67-dihe-in -61.71, -24.62 -51.87, -45.17 APE12-dist-in 7.252 APE11-dist-in 10.434 APE10-dist-in 4.909 APE9-dist-in 3.591 Y288G,Q292A SEP241 SEP241 XRAY 1.31 0.2 0.224 A 311 290 0 0 0 0 [[82, 342]] 1.0 8dqt AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZA O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.622 14.605 BLAminus DFGAsp-rot-in -134.96, -167.36 70.2, 66.13 195.18, 3.89 -101.26, 0.99 293.7, 88.7 -61.05, -29.24 in-in in 8.215 Saltbr-in 2.81 HRD-in -65.12, -49.46 75.7, -10.07 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.38, 111.86 APE9-dihe-na -60.27, -174.97 APE8-dihe-in -55.74, 132.42 APE8-rot-in 303.15 APE67-dihe-in -56.98, -32.17 -55.27, -42.37 APE12-dist-in 11.549 APE11-dist-out 6.544 APE10-dist-out 10.866 APE9-dist-in 4.117 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 A 316 277 9 0 0 9 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZB O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.648 14.776 BLAminus DFGAsp-rot-in -139.38, -168.66 74.13, 69.92 195.84, 3.88 -111.18, 3.04 284.6, 93.64 -63.39, -24.83 in-in in 8.292 Saltbr-in 2.759 HRD-in -64.66, -48.81 76.86, -10.42 in-in-out SNCiio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.43, 114.97 APE9-dihe-na -62.67, -167.65 APE8-dihe-in -63.67, 131.38 APE8-rot-in 299.84 APE67-dihe-in -54.64, -32.97 -56.45, -39.98 APE12-dist-in 11.638 APE11-dist-out 6.397 APE10-dist-out 10.787 APE9-dist-in 4.087 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 B 316 279 8 0 0 8 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZC O15530 74 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.667 14.679 BLAminus DFGAsp-rot-in -134.07, -170.51 76.79, 69.39 195.28, 8.51 -110.34, 1.38 287.93, 89.81 -56.71, -30.43 in-in in 8.225 Saltbr-in 2.804 HRD-in -64.4, -49.76 78.61, -9.94 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -134.53, 111.0 APE9-dihe-na -58.83, -174.56 APE8-dihe-in -56.66, 132.63 APE8-rot-in 302.29 APE67-dihe-in -56.84, -32.58 -55.43, -42.03 APE12-dist-in 11.731 APE11-dist-out 6.55 APE10-dist-out 10.875 APE9-dist-in 4.082 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 C 316 277 9 0 0 9 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZD O15530 73 359 556.0 2A2:1,BI4:360 Allosteric,Type1 Inactive DFGin 6.649 14.774 BLAminus DFGAsp-rot-in -139.63, -168.42 74.39, 69.06 196.4, 3.09 -110.33, 3.29 285.32, 93.06 -63.48, -24.84 in-in in 8.31 Saltbr-in 2.754 HRD-in -64.65, -47.43 73.97, -9.52 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -126.78, 121.12 APE9-dihe-na -63.33, -166.44 APE8-dihe-in -63.66, 131.18 APE8-rot-in 301.29 APE67-dihe-in -54.43, -33.46 -55.31, -40.36 APE12-dist-in 11.584 APE11-dist-out 6.406 APE10-dist-out 10.842 APE9-dist-in 4.04 T148C SEP241 SEP241 XRAY 2.0 0.22 0.265 D 316 279 8 0 0 8 [[82, 342]] 1.0 3orz AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3OTUA O15530 77 359 556.0 J30:1,BI4:360 Allosteric,Type1.5_Front Active DFGin 6.407 14.986 BLAminus DFGAsp-rot-in -147.19, -166.49 62.44, 61.65 193.06, 25.86 -95.64, 10.19 290.91, 105.88 -63.28, -24.6 in-in in 8.37 Saltbr-in 3.337 HRD-in -67.23, -53.13 82.11, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.97, 157.81 APE9-dihe-na 151.4, -176.81 APE8-dihe-in -123.26, 126.19 APE8-rot-in 294.94 APE67-dihe-in -53.95, -30.51 -40.25, -53.87 APE12-dist-in 7.712 APE11-dist-in 10.329 APE10-dist-in 5.244 APE9-dist-in 4.13 T148C SEP241 SEP241 XRAY 2.101 0.197 0.24 A 316 277 6 0 0 5 [[82, 342]] 1.0 3otu AGC_PDPK1_HUMAN AGC 8.2e-85 290.0 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN AF-O15530-K1A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.307 14.752 BLAminus DFGAsp-rot-in -134.14, -175.03 67.73, 56.76 194.33, 25.44 -81.0, 7.09 290.02, 100.1 -62.73, -31.75 in-in in 8.479 Saltbr-in 2.692 HRD-in -71.22, -49.98 68.85, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.76, 160.45 APE9-dihe-na 125.82, -178.56 APE8-dihe-in -110.7, 135.78 APE8-rot-in 301.58 APE67-dihe-in -71.92, -18.9 -54.44, -36.21 APE12-dist-in 7.478 APE11-dist-in 10.746 APE10-dist-in 5.036 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[82, 342]] 1.0 AF-O15530-K1 AGC_PDPK1_HUMAN AGC 8.6e-85 289.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN AF-O15530-K3A O15530 74 350 556.0 No_ligand No_ligand Active DFGin 6.023 14.647 BLAminus DFGAsp-rot-in -139.54, -179.29 63.97, 66.91 201.03, -4.77 -82.88, 11.22 294.97, 97.73 -59.7, -35.74 in-in in 8.729 Saltbr-in 2.655 HRD-in -73.34, -47.9 67.59, -9.95 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 143.7 APE9-dihe-na 124.83, 164.09 APE8-dihe-in -82.81, 130.45 APE8-rot-in 291.03 APE67-dihe-in -71.92, -16.19 -51.02, -35.4 APE12-dist-in 8.387 APE11-dist-in 11.06 APE10-dist-in 5.29 APE9-dist-in 4.362 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[82, 342]] 1.0 AF-O15530-K3 AGC_PDPK1_HUMAN AGC 8.6e-85 289.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1Z5MA O15530 74 359 556.0 LI8:501 Type1 Inactive DFGin 6.966 14.669 BLAminus DFGAsp-rot-in -143.06, -166.04 70.1, 70.4 189.88, 36.84 -106.54, 10.63 285.55, 95.37 -57.95, -38.82 in-in in 8.979 Saltbr-in 2.862 HRD-in -60.53, -42.76 63.99, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.683 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.8, 123.87 APE9-dihe-na -69.98, -168.75 APE8-dihe-in -47.59, 126.16 APE8-rot-in 298.44 APE67-dihe-in -75.58, -18.39 -37.0, -46.81 APE12-dist-in 8.544 APE11-dist-out 6.285 APE10-dist-out 10.457 APE9-dist-in 4.05 None SEP241 SEP241 XRAY 2.17 0.232 0.269 A 286 276 10 0 0 10 [[82, 342]] 1.0 1z5m AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2PE0A O15530 74 359 556.0 39Z:501 Type1 Inactive DFGin 6.447 14.384 BLAminus DFGAsp-rot-in -129.98, -179.46 78.75, 74.81 196.37, 89.69 -106.99, 5.13 286.59, 90.93 -55.7, -29.7 in-in in 8.723 Saltbr-in 2.783 HRD-in -72.01, -55.71 78.26, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.817 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.01, 133.16 APE9-dihe-na -80.12, -143.18 APE8-dihe-in -90.02, 137.86 APE8-rot-in 307.83 APE67-dihe-in -64.54, -15.21 -51.36, -49.75 APE12-dist-in 9.14 APE11-dist-out 5.513 APE10-dist-out 10.103 APE9-dist-in 3.789 None SEP241 SEP241 XRAY 2.35 0.202 0.24 A 286 276 10 0 0 10 [[82, 342]] 1.0 2pe0 AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2PE1A O15530 74 359 556.0 517:501 Type1 Inactive DFGin 6.645 14.682 BLAminus DFGAsp-rot-in -139.4, -175.86 73.15, 71.4 201.02, 32.42 -105.21, 7.65 286.89, 93.63 -52.89, -40.97 in-in in 8.883 Saltbr-in 2.595 HRD-in -69.74, -56.95 81.13, 2.35 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.84, 143.11 APE9-dihe-na -79.47, -134.7 APE8-dihe-in -90.68, 136.03 APE8-rot-in 300.98 APE67-dihe-in -68.92, -11.38 -43.74, -52.34 APE12-dist-in 9.117 APE11-dist-out 5.701 APE10-dist-out 10.38 APE9-dist-in 3.606 None SEP241 SEP241 XRAY 2.14 0.224 0.282 A 286 276 10 0 0 10 [[82, 342]] 1.0 2pe1 AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2PE2A O15530 74 359 556.0 464:501 Type1 Inactive DFGin 6.591 14.415 BLAminus DFGAsp-rot-in -135.75, -175.91 78.63, 72.01 200.13, 36.3 -109.62, 0.43 287.28, 93.19 -54.2, -35.84 in-in in 8.562 Saltbr-in 2.551 HRD-in -75.76, -49.83 75.8, -8.69 in-in-out SNCiio in-out ActLoopNT-in 2.724 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.61, 128.36 APE9-dihe-na -70.67, -166.57 APE8-dihe-in -59.34, 134.44 APE8-rot-in 302.45 APE67-dihe-in -67.69, -11.47 -51.51, -47.62 APE12-dist-in 8.982 APE11-dist-out 5.527 APE10-dist-out 10.312 APE9-dist-in 3.738 None SEP241 SEP241 XRAY 2.13 0.189 0.215 A 286 276 10 0 0 10 [[82, 342]] 1.0 2pe2 AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NUSA O15530 73 358 556.0 JNZ:374 Type1 Inactive DFGin 6.666 14.014 BLAminus DFGAsp-rot-in -134.94, -176.79 67.79, 79.24 191.45, 24.83 -106.97, 14.51 293.69, 91.17 -56.65, -43.75 in-in in 8.614 Saltbr-in 3.105 HRD-in -75.65, -54.6 82.78, -6.2 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.47, 126.95 APE9-dihe-na -67.17, -145.64 APE8-dihe-in -85.86, 130.62 APE8-rot-in 299.93 APE67-dihe-in -70.26, -18.43 -47.43, -45.34 APE12-dist-in 9.476 APE11-dist-out 6.257 APE10-dist-out 10.299 APE9-dist-in 4.029 None SEP241 SEP241 XRAY 2.75 0.177 0.236 A 286 277 9 0 0 9 [[82, 342]] 1.0 3nus AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NUUA O15530 73 358 556.0 JOZ:361 Type1 Inactive DFGin 6.815 14.418 BLAminus DFGAsp-rot-in -135.1, 176.45 77.67, 76.35 184.85, 17.53 -106.62, 4.54 289.58, 95.96 -54.87, -35.17 in-in in 8.663 Saltbr-in 2.646 HRD-in -75.97, -55.36 84.01, -8.4 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.64, 126.08 APE9-dihe-na -69.19, -150.37 APE8-dihe-in -79.82, 127.26 APE8-rot-in 298.22 APE67-dihe-in -66.17, -14.72 -39.18, -51.46 APE12-dist-in 8.929 APE11-dist-out 5.849 APE10-dist-out 10.298 APE9-dist-in 3.991 None SEP241 SEP241 XRAY 1.98 0.189 0.239 A 286 277 9 0 0 9 [[82, 342]] 1.0 3nuu AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NUYA O15530 73 358 556.0 JPZ:370 Type1 Inactive DFGin 6.73 14.55 BLAminus DFGAsp-rot-in -136.81, -175.62 72.08, 77.54 186.87, 20.05 -106.37, 8.07 285.95, 95.42 -50.93, -42.82 in-in in 8.764 Saltbr-in 2.731 HRD-in -78.09, -53.76 79.66, -9.09 in-in-out SNCiio in-out ActLoopNT-in 2.897 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.52, 118.04 APE9-dihe-na -67.36, -159.8 APE8-dihe-in -67.79, 132.38 APE8-rot-in 304.86 APE67-dihe-in -62.4, -17.72 -54.87, -44.81 APE12-dist-in 9.411 APE11-dist-out 5.82 APE10-dist-out 10.278 APE9-dist-in 3.971 None SEP241 SEP241 XRAY 2.1 0.187 0.225 A 286 277 9 0 0 9 [[82, 342]] 1.0 3nuy AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1UU9A O15530 72 357 556.0 BI3:1370 Type1 Inactive DFGin 6.679 14.783 BLAminus DFGAsp-rot-in -137.61, -169.2 68.82, 72.55 194.78, 11.41 -103.82, -0.34 285.88, 98.86 -59.49, -32.23 in-in in 8.326 Saltbr-in 2.697 HRD-in -73.71, -52.28 77.02, -6.6 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.15, 123.88 APE9-dihe-na -73.46, -162.02 APE8-dihe-in -55.23, 126.59 APE8-rot-in 305.35 APE67-dihe-in -59.52, -20.56 -41.52, -52.97 APE12-dist-in 9.339 APE11-dist-out 5.502 APE10-dist-out 10.273 APE9-dist-in 3.777 None SEP241 SEP241 XRAY 1.95 0.176 0.224 A 286 277 9 0 0 9 [[82, 342]] 1.0 1uu9 AGC_PDPK1_HUMAN AGC 9.7e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1UVRA O15530 71 359 556.0 BI8:1372 Type1 Inactive DFGin 6.581 14.406 BLAminus DFGAsp-rot-in -141.7, -169.27 62.75, 72.58 181.98, 49.93 -105.41, 8.55 300.9, 81.55 -59.95, -35.71 in-in in 8.595 Saltbr-in 2.983 HRD-in -62.43, -49.82 76.81, -6.44 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -133.17, 120.18 APE9-dihe-na -60.87, -168.42 APE8-dihe-in -53.67, 135.35 APE8-rot-in 308.99 APE67-dihe-in -63.6, -1.85 -44.81, -56.98 APE12-dist-in 7.288 APE11-dist-out 6.643 APE10-dist-out 10.614 APE9-dist-in 4.09 None SEP241 SEP241 XRAY 2.81 0.176 0.248 A 289 285 4 0 0 4 [[82, 342]] 1.0 1uvr AGC_PDPK1_HUMAN AGC 1e-84 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NUNA O15530 71 358 556.0 JMZ:361 Type1 Inactive DFGin 6.472 14.221 BLAminus DFGAsp-rot-in -136.64, 178.66 75.33, 84.73 199.69, -4.9 -114.4, 16.28 293.69, 90.85 -60.42, -36.06 in-in in 8.672 Saltbr-in 2.787 HRD-in -68.71, -51.25 77.84, -3.6 in-in-out SNCiio in-out ActLoopNT-in 2.836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.38, 127.64 APE9-dihe-na -69.91, -151.05 APE8-dihe-in -80.37, 125.09 APE8-rot-in 310.77 APE67-dihe-in -66.15, -18.43 -42.77, -46.09 APE12-dist-in 8.969 APE11-dist-out 5.896 APE10-dist-out 10.417 APE9-dist-in 4.314 None SEP241 SEP241 XRAY 2.2 0.18 0.227 A 292 279 9 0 0 9 [[82, 342]] 1.0 3nun AGC_PDPK1_HUMAN AGC 1.1e-84 289.6 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2XCHA O15530 73 359 556.0 CKG:1360 Type1 Inactive DFGin 6.734 14.529 BLAminus DFGAsp-rot-in -129.58, 177.2 73.14, 77.15 194.17, 3.65 -102.2, 9.9 285.13, 96.86 -57.37, -39.89 in-in in 8.698 Saltbr-in 2.571 HRD-in -76.48, -53.27 78.53, -7.84 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.55, 124.18 APE9-dihe-na -77.48, -153.81 APE8-dihe-in -63.6, 127.96 APE8-rot-in 306.17 APE67-dihe-in -61.93, -18.13 -48.28, -49.39 APE12-dist-in 9.286 APE11-dist-out 5.691 APE10-dist-out 10.342 APE9-dist-in 3.891 None SEP241 SEP241 XRAY 2.0 0.191 0.226 A 309 279 8 0 0 8 [[82, 342]] 1.0 2xch AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5HKMA O15530 76 358 556.0 61Y:403 Type1 Inactive DFGin 6.428 14.15 BLAminus DFGAsp-rot-in -122.57, -157.08 51.69, 73.85 183.6, 24.35 -100.67, 14.09 281.12, 81.43 -62.59, -33.63 in-in in 8.649 Saltbr-in 2.807 HRD-in -66.63, -45.86 63.42, -2.09 in-in-out SNCiio in-out ActLoopNT-in 2.761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -140.98, 122.73 APE9-dihe-na -75.89, -160.0 APE8-dihe-in -62.57, 122.86 APE8-rot-in 309.65 APE67-dihe-in -56.46, -24.28 -29.66, -64.05 APE12-dist-in 9.647 APE11-dist-out 5.802 APE10-dist-out 10.271 APE9-dist-in 3.798 None SEP241 SEP241 XRAY 2.1 0.228 0.273 A 309 273 10 0 0 10 [[82, 342]] 1.0 5hkm AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5HNGA O15530 71 359 556.0 62O:403 Type1 Inactive DFGin 6.502 14.356 BLAminus DFGAsp-rot-in -131.37, -170.36 61.15, 71.88 176.36, 42.16 -92.77, 10.44 287.92, 92.83 -55.25, -43.3 in-in in 8.828 Saltbr-in 2.873 HRD-in -61.06, -47.37 70.67, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.82, 119.15 APE9-dihe-na -68.32, -153.72 APE8-dihe-in -67.95, 131.45 APE8-rot-in 305.81 APE67-dihe-in -63.0, -22.16 -48.07, -47.57 APE12-dist-in 9.026 APE11-dist-out 5.746 APE10-dist-out 10.521 APE9-dist-in 4.032 None SEP241 SEP241 XRAY 3.01 0.176 0.243 A 309 281 8 0 0 8 [[82, 342]] 1.0 5hng AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5HO7A O15530 71 359 556.0 63L:701 Type1 Inactive DFGin 6.5 13.998 BLAminus DFGAsp-rot-out -138.45, -177.98 79.97, 72.22 241.97, 37.8 -103.24, 8.72 293.52, 91.58 -60.99, -44.96 in-in in 8.584 Saltbr-in 3.069 HRD-in -62.96, -39.76 64.33, -4.25 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.91, 120.25 APE9-dihe-na -71.94, -150.13 APE8-dihe-in -74.96, 128.19 APE8-rot-in 303.71 APE67-dihe-in -61.52, -27.36 -46.49, -48.45 APE12-dist-in 9.459 APE11-dist-out 6.016 APE10-dist-out 10.318 APE9-dist-in 4.123 None SEP241 SEP241 XRAY 3.0 0.175 0.233 A 309 281 8 0 0 8 [[82, 342]] 1.0 5ho7 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5HO8A O15530 71 358 556.0 63E:701 Type1 Inactive DFGin 6.326 13.727 BLAminus DFGAsp-rot-in -137.78, 179.62 80.28, 69.7 204.48, -11.41 -100.25, 11.3 296.62, 94.66 -58.72, -47.18 in-in in 8.743 Saltbr-in 3.023 HRD-in -65.39, -42.86 64.55, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -124.41, 121.86 APE9-dihe-na -70.34, -152.74 APE8-dihe-in -66.74, 122.4 APE8-rot-in 293.45 APE67-dihe-in -65.08, -24.35 -41.28, -45.91 APE12-dist-in 9.145 APE11-dist-out 5.926 APE10-dist-out 10.238 APE9-dist-in 4.059 None SEP241 SEP241 XRAY 2.7 0.184 0.229 A 309 279 9 0 0 9 [[82, 342]] 1.0 5ho8 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1OKYA O15530 72 360 556.0 STU:1368 Type1 Inactive DFGin 6.153 14.462 BLAminus DFGAsp-rot-in -148.97, -170.84 70.56, 80.45 198.11, -14.86 -102.75, 23.82 286.84, 96.04 -69.28, -20.21 in-in in 8.672 Saltbr-in 2.673 HRD-in -67.69, -57.78 80.28, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.7, -80.59 APE9-dihe-na 115.49, 169.91 APE8-dihe-in -54.49, 123.73 APE8-rot-in 316.76 APE67-dihe-in -63.35, -17.55 -42.07, -50.54 APE12-dist-in 9.289 APE11-dist-out 5.556 APE10-dist-out 9.719 APE9-dist-in 4.222 None SEP241 SEP241 XRAY 2.3 0.219 0.255 A 310 283 6 0 0 6 [[82, 342]] 1.0 1oky AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1OKZA O15530 73 359 556.0 UCN:1370 Type1 Inactive DFGin 6.544 14.168 BLAminus DFGAsp-rot-in -141.57, -164.78 67.55, 76.85 196.84, -2.53 -103.78, 11.05 287.85, 85.4 -63.67, 2.06 in-in in 8.727 Saltbr-in 2.717 HRD-in -70.44, -54.0 75.32, 3.69 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.16, 105.01 APE9-dihe-na -62.12, -140.62 APE8-dihe-in -78.85, 125.76 APE8-rot-in 304.75 APE67-dihe-in -63.07, -21.46 -38.09, -52.99 APE12-dist-in 9.557 APE11-dist-out 6.099 APE10-dist-out 10.408 APE9-dist-in 4.166 None SEP241 SEP241 XRAY 2.51 0.19 0.257 A 310 278 9 0 0 9 [[82, 342]] 1.0 1okz AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1UU3A O15530 73 360 556.0 LY4:1374 Type1 Inactive DFGin 6.596 14.971 BLAminus DFGAsp-rot-in -134.47, -173.45 74.38, 73.99 195.25, 19.54 -109.66, 0.57 283.46, 101.61 -63.98, -27.2 in-in in 8.275 Saltbr-in 2.817 HRD-in -64.65, -55.05 74.86, -6.55 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.92, 125.5 APE9-dihe-na -77.61, -163.62 APE8-dihe-in -56.98, 127.76 APE8-rot-in 299.91 APE67-dihe-in -61.39, -22.49 -53.63, -41.57 APE12-dist-in 9.202 APE11-dist-out 5.466 APE10-dist-out 10.407 APE9-dist-in 4.048 None SEP241 SEP241 XRAY 1.7 0.174 0.202 A 310 278 10 0 0 10 [[82, 342]] 1.0 1uu3 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1UU7A O15530 73 359 556.0 BI2:1364 Type1 Inactive DFGin 6.557 14.742 BLAminus DFGAsp-rot-in -136.5, -171.94 74.29, 73.79 193.8, 11.7 -109.8, -2.64 287.37, 96.13 -53.85, -39.14 in-in in 8.463 Saltbr-in 2.88 HRD-in -68.07, -51.28 73.99, -8.84 in-in-out SNCiio in-out ActLoopNT-in 2.833 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.82, 121.67 APE9-dihe-na -67.64, -173.23 APE8-dihe-in -49.06, 125.05 APE8-rot-in 301.64 APE67-dihe-in -67.12, -19.88 -49.14, -41.33 APE12-dist-in 8.914 APE11-dist-out 5.317 APE10-dist-out 10.267 APE9-dist-in 3.91 None SEP241 SEP241 XRAY 1.9 0.235 0.279 A 310 282 5 0 0 5 [[82, 342]] 1.0 1uu7 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 1UU8A O15530 72 358 556.0 BI1:1368 Type1 Inactive DFGin 6.647 14.471 BLAminus DFGAsp-rot-in -136.37, -165.37 63.01, 71.98 188.47, 29.08 -101.9, 2.54 288.65, 101.81 -58.08, -33.97 in-in in 8.815 Saltbr-in 2.728 HRD-in -71.97, -53.07 75.47, 11.05 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -142.67, 117.85 APE9-dihe-na -65.71, -160.29 APE8-dihe-in -63.31, 129.15 APE8-rot-in 297.13 APE67-dihe-in -68.38, -3.88 -40.88, -48.91 APE12-dist-in 9.238 APE11-dist-out 5.653 APE10-dist-out 10.088 APE9-dist-in 3.759 None SEP241 SEP241 XRAY 2.5 0.176 0.258 A 310 279 8 0 0 8 [[82, 342]] 1.0 1uu8 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NAYA O15530 76 362 556.0 MP6:1 Type1 Inactive DFGin 6.764 14.658 BLAminus DFGAsp-rot-in -146.79, -173.04 72.2, 70.67 209.98, 24.77 -103.69, 5.05 296.95, 109.64 -60.79, -27.91 in-in in 8.557 Saltbr-in 2.565 HRD-in -62.07, -50.65 74.17, -9.68 in-in-out SNCiio in-out ActLoopNT-in 2.74 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.84, 118.23 APE9-dihe-na -69.99, -167.96 APE8-dihe-in -54.98, 129.37 APE8-rot-in 302.57 APE67-dihe-in -65.83, -27.98 -54.2, -37.6 APE12-dist-in 8.6 APE11-dist-out 5.619 APE10-dist-out 10.531 APE9-dist-in 3.839 None SEP241 SEP241 XRAY 2.6 0.211 0.274 A 311 279 8 0 0 8 [[82, 342]] 1.0 3nay AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NAYB O15530 76 362 556.0 MP6:2 Type1 Inactive DFGin 6.879 14.367 BLAminus DFGAsp-rot-in -131.67, -178.35 72.0, 77.09 199.99, 7.26 -107.77, 17.41 299.66, 102.49 -69.46, -28.42 in-in in 8.33 Saltbr-in 2.824 HRD-in -70.5, -49.88 76.39, -13.79 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 114.84, 100.21 APE9-dihe-na -68.09, -163.03 APE8-dihe-in -59.66, 125.08 APE8-rot-in 300.78 APE67-dihe-in -68.69, -23.52 -42.99, -40.54 APE12-dist-in 8.729 APE11-dist-out 5.837 APE10-dist-out 10.602 APE9-dist-in 3.884 None SEP241 SEP241 XRAY 2.6 0.211 0.274 B 311 279 8 0 0 8 [[82, 342]] 1.0 3nay AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3RWPA O15530 73 359 556.0 ABQ:360 Type1 Inactive DFGin 6.63 14.612 BLAminus DFGAsp-rot-in -138.06, -171.84 73.21, 68.9 184.17, 14.3 -101.84, 0.77 284.24, 99.91 -67.12, -24.97 in-in in 8.487 Saltbr-in 2.668 HRD-in -72.19, -48.95 75.52, -7.14 in-in-out SNCiio in-out ActLoopNT-in 2.844 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.4, 122.62 APE9-dihe-na -64.5, -165.33 APE8-dihe-in -62.97, 132.8 APE8-rot-in 302.69 APE67-dihe-in -57.73, -26.43 -57.73, -39.86 APE12-dist-in 9.571 APE11-dist-out 5.748 APE10-dist-out 10.613 APE9-dist-in 4.202 None SEP241 SEP241 XRAY 1.92 0.174 0.213 A 311 278 9 0 0 9 [[82, 342]] 1.0 3rwp AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3RWQA O15530 72 359 556.0 3RW:1 Type1 Inactive DFGin 6.589 14.463 BLAminus DFGAsp-rot-in -143.65, -172.61 68.52, 70.31 194.56, 23.53 -102.07, 3.38 289.03, 95.5 -56.64, -39.2 in-in in 8.565 Saltbr-in 2.728 HRD-in -70.4, -52.28 81.8, -9.17 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.88, 122.18 APE9-dihe-na -69.74, -149.03 APE8-dihe-in -75.72, 125.93 APE8-rot-in 318.02 APE67-dihe-in -73.55, -21.89 -37.75, -44.68 APE12-dist-in 9.207 APE11-dist-out 5.879 APE10-dist-out 10.524 APE9-dist-in 4.016 None SEP241 SEP241 XRAY 2.55 0.196 0.256 A 311 284 4 0 0 4 [[82, 342]] 1.0 3rwq AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3SC1A O15530 73 359 556.0 3S1:900 Type1 Active DFGin 6.433 14.115 BLAminus DFGAsp-rot-in -125.85, 175.62 82.13, 80.63 188.87, 73.98 -113.39, 8.45 290.85, 87.77 -53.07, -47.22 in-in in 8.708 Saltbr-in 3.216 HRD-in -72.93, -48.81 80.48, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.12, -172.48 APE9-dihe-na 115.93, 147.74 APE8-dihe-in -93.61, 137.68 APE8-rot-in 299.7 APE67-dihe-in -55.26, -32.91 -54.79, -48.8 APE12-dist-in 8.739 APE11-dist-in 10.606 APE10-dist-in 5.411 APE9-dist-in 3.986 None SEP241 SEP241 XRAY 2.7 0.2 0.237 A 311 279 8 0 0 8 [[82, 342]] 1.0 3sc1 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3H9OA O15530 75 359 556.0 9BD:1 Type1 Inactive DFGin 6.568 14.261 BLAminus DFGAsp-rot-in -131.94, -168.71 66.62, 79.57 202.01, -0.33 -104.6, 18.2 283.3, 82.81 -72.27, -11.03 in-in in 8.876 Saltbr-in 2.544 HRD-in -78.26, -52.42 80.3, -1.11 in-in-out SNCiio in-out ActLoopNT-in 2.81 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 77.5, 119.89 APE9-dihe-na -89.12, -112.65 APE8-dihe-in -101.23, 134.92 APE8-rot-in 301.13 APE67-dihe-in -62.27, -18.27 -50.83, -50.03 APE12-dist-in 9.643 APE11-dist-out 6.268 APE10-dist-out 10.174 APE9-dist-in 3.934 None SEP241 SEP241 XRAY 2.3 0.211 0.256 A 311 276 9 0 0 9 [[82, 342]] 1.0 3h9o AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2R7BA O15530 75 359 556.0 253:701 Type1 Inactive DFGin 6.199 14.366 BLAminus DFGAsp-rot-in -133.94, -179.49 77.82, 81.49 212.91, -13.45 -108.24, 22.02 291.13, 86.98 -68.69, -10.97 in-in in 8.866 Saltbr-in 2.588 HRD-in -75.75, -47.44 52.14, 30.84 in-in-out SNCiio in-out ActLoopNT-in 2.798 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 148.51, 113.35 APE9-dihe-na -77.58, -157.1 APE8-dihe-in -58.21, 135.29 APE8-rot-in 301.99 APE67-dihe-in -57.75, -20.67 -44.89, -55.44 APE12-dist-in 9.197 APE11-dist-out 5.773 APE10-dist-out 9.887 APE9-dist-in 4.096 None SEP241 SEP241 XRAY 2.7 0.225 0.25 A 312 275 10 0 0 10 [[82, 342]] 1.0 2r7b AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3IONA O15530 75 359 556.0 8H1:1 Type1 Inactive DFGin 6.386 14.012 BLAminus DFGAsp-rot-in -129.57, -169.56 64.12, 80.16 192.58, 6.46 -106.23, 22.91 285.85, 87.72 -68.81, -24.37 in-in in 8.931 Saltbr-in 3.337 HRD-in -74.01, -54.84 77.47, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.7 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.89 APE9-dihe-na -88.46, -116.13 APE8-dihe-in -104.9, 134.52 APE8-rot-in 307.56 APE67-dihe-in -73.92, -18.65 -45.98, -45.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.08 APE9-dist-in 3.603 None None None XRAY 2.4 0.246 0.282 A 312 274 11 0 0 11 [[82, 342]] 1.0 3ion AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3IOPA O15530 75 359 556.0 8I1:1 Type1 Inactive DFGin 6.606 14.316 BLAminus DFGAsp-rot-in -125.3, -165.97 58.12, 80.1 194.75, 9.69 -105.24, 23.38 285.73, 86.81 -73.19, -11.32 in-in in 8.806 Saltbr-in 2.681 HRD-in -71.7, -52.98 78.46, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 67.02, 113.91 APE9-dihe-na -74.5, -127.28 APE8-dihe-in -97.61, 129.5 APE8-rot-in 303.0 APE67-dihe-in -63.74, -18.61 -44.16, -50.92 APE12-dist-in 9.57 APE11-dist-out 5.969 APE10-dist-out 10.465 APE9-dist-in 3.791 None SEP241 SEP241 XRAY 2.2 0.24 0.278 A 312 276 9 0 0 9 [[82, 342]] 1.0 3iop AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCQA O15530 73 358 556.0 3Q0:370 Type1 Inactive DFGin 6.286 13.943 BLAminus DFGAsp-rot-in -130.07, -172.39 67.81, 84.85 187.97, 9.16 -116.19, 10.14 290.92, 91.68 -60.0, -35.96 in-in in 8.668 Saltbr-in 2.817 HRD-in -76.77, -43.93 72.04, -4.3 in-in-out SNCiio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -127.34, 117.15 APE9-dihe-na -68.0, -161.08 APE8-dihe-in -59.72, 132.52 APE8-rot-in 308.25 APE67-dihe-in -73.95, -13.03 -56.44, -42.24 APE12-dist-in 9.322 APE11-dist-out 6.216 APE10-dist-out 10.326 APE9-dist-in 4.208 None SEP241 SEP241 XRAY 2.501 0.181 0.251 A 312 277 9 0 0 9 [[82, 342]] 1.0 3qcq AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCSA O15530 73 358 556.0 3Q1:370 Type1 Inactive DFGin 6.498 14.342 BLAminus DFGAsp-rot-in -129.15, -172.55 69.95, 84.25 180.69, 11.38 -118.54, 4.81 283.02, 93.04 -59.77, -28.42 in-in in 8.591 Saltbr-in 2.808 HRD-in -71.62, -47.65 74.15, -7.51 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -125.7, 120.85 APE9-dihe-na -72.97, -164.1 APE8-dihe-in -54.02, 130.58 APE8-rot-in 312.22 APE67-dihe-in -61.81, -24.07 -54.55, -47.19 APE12-dist-in 9.235 APE11-dist-out 6.334 APE10-dist-out 10.536 APE9-dist-in 4.407 None SEP241 SEP241 XRAY 2.487 0.182 0.251 A 312 277 9 0 0 9 [[82, 342]] 1.0 3qcs AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3RCJA O15530 77 358 556.0 3RC:0 Type1 Active DFGin 6.55 14.392 BLAminus DFGAsp-rot-in -128.99, -167.62 59.76, 67.13 209.12, -1.28 -93.27, 12.1 286.78, 86.8 -60.54, -37.27 in-in in 8.539 Saltbr-in 2.786 HRD-in -65.85, -49.34 77.48, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.08, 164.56 APE9-dihe-na 127.57, -173.24 APE8-dihe-in -123.98, 130.3 APE8-rot-in 296.56 APE67-dihe-in -63.09, -20.07 -49.59, -44.96 APE12-dist-in 7.83 APE11-dist-in 10.746 APE10-dist-in 5.025 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 1.7 0.217 0.198 A 311 282 0 0 0 0 [[82, 342]] 1.0 3rcj AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVLA O15530 74 359 556.0 537:401 Type1 Active DFGin 6.596 14.602 BLAminus DFGAsp-rot-in -130.64, -179.01 78.07, 78.29 191.88, 12.9 -107.64, 5.9 287.24, 98.42 -64.3, -24.0 in-in in 8.293 Saltbr-in 2.558 HRD-in -74.44, -52.48 78.34, -12.89 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.91, 163.01 APE9-dihe-na 134.48, -168.83 APE8-dihe-in -131.23, 133.97 APE8-rot-in 296.05 APE67-dihe-in -61.17, -24.01 -50.83, -47.55 APE12-dist-in 7.321 APE11-dist-in 10.47 APE10-dist-in 4.881 APE9-dist-in 3.565 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.154 0.178 A 311 286 0 0 0 0 [[82, 342]] 1.0 5lvl AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVMA O15530 76 359 556.0 ADE:401 Type1 Active DFGin 6.515 14.858 BLAminus DFGAsp-rot-in -134.29, -178.73 78.5, 76.19 196.79, 18.83 -107.92, 3.05 284.81, 100.85 -68.49, -15.39 in-in in 8.399 Saltbr-in 2.922 HRD-in -74.83, -53.98 76.68, -6.53 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 160.72 APE9-dihe-na 136.54, -165.87 APE8-dihe-in -131.32, 134.23 APE8-rot-in 298.42 APE67-dihe-in -62.0, -21.56 -53.2, -46.03 APE12-dist-in 7.426 APE11-dist-in 10.557 APE10-dist-in 4.949 APE9-dist-in 3.534 Y288G,Q292A SEP241 SEP241 XRAY 1.26 0.135 0.155 A 311 284 0 0 0 0 [[82, 342]] 1.0 5lvm AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVNA O15530 75 359 556.0 ADN:402 Type1 Active DFGin 6.493 14.784 BLAminus DFGAsp-rot-in -138.56, -175.41 73.41, 75.09 199.3, 25.53 -105.63, 5.44 285.54, 101.95 -63.79, -19.6 in-in in 8.435 Saltbr-in 2.739 HRD-in -74.59, -52.51 78.18, -12.02 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.48, 161.66 APE9-dihe-na 136.02, -164.27 APE8-dihe-in -134.21, 135.25 APE8-rot-in 295.47 APE67-dihe-in -61.9, -23.15 -53.94, -45.84 APE12-dist-in 7.439 APE11-dist-in 10.533 APE10-dist-in 4.893 APE9-dist-in 3.566 Y288G,Q292A SEP241 SEP241 XRAY 1.379 0.135 0.162 A 311 285 0 0 0 0 [[82, 342]] 1.0 5lvn AGC_PDPK1_HUMAN AGC 7.1e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3PWYA O15530 71 359 556.0 SYP:1 Type1 Inactive DFGin 6.477 14.483 BLAminus DFGAsp-rot-in -124.65, -178.35 67.96, 96.3 181.91, 14.76 -130.58, 11.45 300.55, 97.42 -64.93, -31.03 in-in in 8.587 Saltbr-in 2.693 HRD-in -58.86, -48.53 68.39, -3.99 in-in-out SNCiio in-out ActLoopNT-in 2.761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.65, 129.21 APE9-dihe-na -78.78, -151.6 APE8-dihe-in -77.12, 126.15 APE8-rot-in 307.61 APE67-dihe-in -78.87, -27.54 -44.08, -37.51 APE12-dist-in 10.327 APE11-dist-out 5.848 APE10-dist-out 10.58 APE9-dist-in 3.855 E166C,C260S None None XRAY 3.5 0.226 0.276 A 311 281 8 0 0 8 [[82, 342]] 1.0 3pwy AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2XCKA O15530 76 359 556.0 MH4:1360 Type1 Inactive DFGin 6.777 14.728 BLAminus DFGAsp-rot-in -138.18, -175.27 71.05, 75.56 189.01, 1.81 -104.69, 7.11 286.41, 101.4 -56.07, -44.06 in-in in 8.722 Saltbr-in 2.723 HRD-in -74.69, -54.88 79.61, -3.05 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -108.24, 134.08 APE9-dihe-na -87.44, -159.07 APE8-dihe-in -56.55, 126.47 APE8-rot-in 304.89 APE67-dihe-in -62.34, -18.12 -47.8, -48.47 APE12-dist-in 9.333 APE11-dist-out 5.513 APE10-dist-out 10.402 APE9-dist-in 3.875 None SEP241 SEP241 XRAY 2.3 0.195 0.24 A 309 276 8 0 0 8 [[82, 342]] 1.0 2xck AGC_PDPK1_HUMAN AGC 1.9e-83 285.5 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCXA O15530 73 358 556.0 3Q2:370 Type1.5_Back Inactive DFGin 6.566 14.448 BLAminus DFGAsp-rot-in -128.85, -170.97 71.83, 79.3 178.1, 19.8 -115.33, 7.3 284.13, 92.7 -60.73, -28.9 in-in in 8.402 Saltbr-in 2.706 HRD-in -68.18, -50.11 76.96, -14.11 in-in-out SNCiio in-out ActLoopNT-in 2.803 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.89, 122.06 APE9-dihe-na -67.11, -167.83 APE8-dihe-in -62.01, 135.81 APE8-rot-in 308.12 APE67-dihe-in -61.25, -24.88 -55.14, -44.7 APE12-dist-in 9.465 APE11-dist-out 6.373 APE10-dist-out 10.323 APE9-dist-in 4.269 None SEP241 SEP241 XRAY 2.3 0.184 0.225 A 312 277 9 0 0 9 [[82, 342]] 1.0 3qcx AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QCYA O15530 73 358 556.0 3Q3:371 Type1.5_Front Inactive DFGin 6.388 14.592 BLAminus DFGAsp-rot-in -136.93, -173.16 70.99, 75.14 183.59, 13.71 -110.32, 14.26 284.13, 86.28 -62.73, -28.34 in-in in 8.419 Saltbr-in 2.559 HRD-in -71.32, -53.51 82.01, -8.81 in-in-out SNCiio in-out ActLoopNT-in 2.825 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 125.83 APE9-dihe-na -76.07, -148.77 APE8-dihe-in -79.07, 127.11 APE8-rot-in 312.38 APE67-dihe-in -58.65, -24.48 -40.2, -55.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.317 APE9-dist-in 4.499 None SEP241 SEP241 XRAY 2.2 0.181 0.212 A 312 275 11 0 0 11 [[82, 342]] 1.0 3qcy AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.584 14.791 BLAminus DFGAsp-rot-in -135.89, -173.14 73.55, 73.02 182.88, 14.17 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.526 Saltbr-in 2.573 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.765 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312 274 12 0 0 12 [[82, 342]] 1.0 3qd0 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD3A O15530 71 358 556.0 3Q5:360 Type1.5_Front Inactive DFGin 6.64 14.776 BLAminus DFGAsp-rot-in -136.15, -173.35 75.08, 78.84 181.88, 8.0 -114.86, 7.79 284.21, 92.48 -60.8, -30.07 in-in in 8.47 Saltbr-in 2.547 HRD-in -69.84, -52.9 76.92, -8.58 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.87, 124.76 APE9-dihe-na -70.78, -165.19 APE8-dihe-in -61.65, 129.32 APE8-rot-in 306.27 APE67-dihe-in -62.1, -22.78 -46.86, -49.49 APE12-dist-in 8.992 APE11-dist-out 5.734 APE10-dist-out 10.414 APE9-dist-in 4.038 None SEP241 SEP241 XRAY 2.0 0.185 0.211 A 312 279 9 0 0 9 [[82, 342]] 1.0 3qd3 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.403 14.626 BLAminus DFGAsp-rot-in -137.72, -173.39 72.99, 75.84 178.14, 13.4 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.558 Saltbr-in 2.79 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.12 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312 276 12 0 0 12 [[82, 342]] 1.0 3qd4 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3NAXA O15530 76 360 556.0 MP7:363 Type2 Inactive DFGout 15.13 9.52 BBAminus DFGAsp-rot-in -103.03, 154.8 -117.91, 140.31 171.8, 44.68 -115.35, 34.44 271.6, 90.85 93.28, 8.79 out-out out 17.084 Saltbr-out 10.258 HRD-in -72.23, -50.17 78.89, -10.91 out-in-none SNCoin in-none ActLoopNT-in 2.852 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.19, -19.08 999.0, -56.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.166 0.195 A 311 278 7 0 0 7 [[82, 342]] 1.0 3nax AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QC4A O15530 76 359 556.0 MP7:60001 Type2 Inactive DFGout 15.145 8.418 BBAminus DFGAsp-rot-in -116.84, 146.54 -96.89, 143.53 175.37, 36.99 -123.04, 29.2 249.8, 111.12 113.47, -5.45 out-out out 19.868 Saltbr-out 17.818 HRD-in -79.45, -51.8 76.86, -8.13 out-in-in SNCoii in-in ActLoopNT-in 3.035 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.28, 161.52 APE9-dihe-na 127.76, -165.1 APE8-dihe-in -132.92, 137.19 APE8-rot-in 293.31 APE67-dihe-in -63.51, -29.78 -55.77, -40.56 APE12-dist-in 7.646 APE11-dist-in 10.891 APE10-dist-in 5.098 APE9-dist-in 3.603 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 A 314 277 7 0 0 7 [[82, 342]] 1.0 3qc4 AGC_PDPK1_HUMAN AGC 5.6e-84 287.2 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QC4B O15530 51 359 556.0 MP7:60002 Type2 Inactive DFGout 15.503 8.299 None DFGAsp-rot-in -106.7, 145.77 -96.8, 153.42 173.36, 46.51 -131.45, 34.1 235.15, 115.54 107.65, 4.91 out-out out 18.058 Saltbr-out 15.17 HRD-in -74.82, -53.49 77.73, -9.15 out-in-in SNCoii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.95, 158.08 APE9-dihe-na 130.3, -155.43 APE8-dihe-in -143.11, 135.86 APE8-rot-in 293.55 APE67-dihe-in -66.08, -20.71 -55.87, -43.65 APE12-dist-in 7.671 APE11-dist-in 10.946 APE10-dist-in 5.068 APE9-dist-in 3.539 E303A,K304A SEP241 SEP241 XRAY 1.8 0.174 0.213 B 314 274 15 0 0 7 [[82, 342]] 1.0 3qc4 AGC_PDPK1_HUMAN AGC 5.6e-84 287.2 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PKN1 PKN1_HUMAN 4OTDA Q16512 605 940 942.0 No_ligand No_ligand Inactive DFGin 7.36 12.696 ABAminus DFGAsp-rot-in -114.19, -18.5 -138.56, 150.95 186.56, 76.08 -133.34, 23.62 298.57, 89.18 -66.17, -19.07 in-in in 9.762 Saltbr-in 2.551 HRD-in -83.06, -49.66 76.99, -22.78 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.27, 161.28 APE9-dihe-na 106.58, 166.23 APE8-dihe-in -86.12, 113.11 APE8-rot-in 305.18 APE67-dihe-in -71.87, -13.23 -45.86, -32.67 APE12-dist-in 8.346 APE11-dist-in 11.733 APE10-dist-in 6.109 APE9-dist-in 4.806 None TPO774,SEP916 TPO774,SEP916 XRAY 2.0 0.177 0.221 A 341 336 0 0 0 0 [[615, 874]] 1.0 4otd AGC_PKN1_HUMAN AGC 2e-90 308.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN 4OTGA Q16512 605 940 942.0 2V9:61001 Type1 Inactive DFGin 6.739 12.449 ABAminus DFGAsp-rot-in -116.77, -25.12 -127.23, 113.95 188.68, -8.21 -111.64, 25.58 303.73, 88.71 -62.85, -32.83 in-in in 9.381 Saltbr-in 3.133 HRD-in -89.2, -47.92 78.18, -34.6 in-in-in SNCiii in-in ActLoopNT-in 3.093 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.02, 157.82 APE9-dihe-na 102.38, 173.73 APE8-dihe-in -80.23, 111.75 APE8-rot-in 307.07 APE67-dihe-in -68.66, -15.76 -46.78, -35.82 APE12-dist-in 8.334 APE11-dist-in 11.669 APE10-dist-in 6.056 APE9-dist-in 5.423 None TPO774,SEP916 TPO774,SEP916 XRAY 2.6 0.212 0.268 A 341 324 0 0 0 0 [[615, 874]] 1.0 4otg AGC_PKN1_HUMAN AGC 2e-90 308.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN AF-Q16512-K1A Q16512 607 882 942.0 No_ligand No_ligand Active DFGin 6.125 12.803 BLAminus DFGAsp-rot-in -104.04, -164.64 32.68, 89.18 203.0, 3.6 -91.79, 14.64 301.92, 91.88 -63.04, -27.24 in-in in 9.067 Saltbr-in 2.671 HRD-in -84.1, -49.81 66.41, 1.28 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.08, 154.4 APE9-dihe-na 137.89, 173.8 APE8-dihe-in -75.84, 131.35 APE8-rot-in 298.99 APE67-dihe-in -68.2, -19.42 -47.26, -48.97 APE12-dist-in 8.484 APE11-dist-in 11.508 APE10-dist-in 5.848 APE9-dist-in 3.561 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[615, 874]] 1.0 AF-Q16512-K1 AGC_PKN1_HUMAN AGC 9.3e-91 309.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN AF-Q16512-K3A Q16512 607 882 942.0 No_ligand No_ligand Active DFGin 5.87 13.023 BLAminus DFGAsp-rot-in -110.25, -171.62 42.06, 78.21 204.99, 8.68 -81.03, 13.32 306.32, 97.97 -64.16, -27.17 in-in in 8.964 Saltbr-in 2.7 HRD-in -80.36, -49.64 68.98, 3.43 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.89, 155.38 APE9-dihe-na 131.55, -178.6 APE8-dihe-in -90.87, 131.72 APE8-rot-in 298.43 APE67-dihe-in -65.82, -21.14 -44.47, -52.21 APE12-dist-in 8.575 APE11-dist-in 11.483 APE10-dist-in 5.841 APE9-dist-in 3.369 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[615, 874]] 1.0 AF-Q16512-K3 AGC_PKN1_HUMAN AGC 9.3e-91 309.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN 4OTHA Q16512 606 940 942.0 DRN:61001 Type1 Inactive DFGin 5.327 13.288 BLAplus DFGAsp-rot-in -95.02, 155.9 62.95, 34.93 206.38, 31.56 -89.79, -14.47 67.06, 79.11 -76.51, -15.56 in-in in 9.79 Saltbr-in 2.997 HRD-in -77.84, -54.58 76.79, -52.02 in-out-none SNCion out-none ActLoopNT-out 6.278 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO774,SEP916 TPO774,SEP916 XRAY 1.8 0.204 0.266 A 341 306 29 0 0 22 [[615, 874]] 1.0 4oth AGC_PKN1_HUMAN AGC 2e-90 308.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN1 PKN1_HUMAN 4OTIA Q16512 606 940 942.0 MI1:61001 Type1 Inactive DFGin 4.779 13.611 BLAplus DFGAsp-rot-out -100.89, 152.42 49.3, 49.67 279.85, -14.67 -84.2, -8.42 65.57, 87.61 -86.86, -16.27 in-in in 9.597 Saltbr-in 2.577 HRD-in -94.1, -68.68 77.6, -28.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO774,SEP916 TPO774,SEP916 XRAY 1.93 0.187 0.226 A 341 304 31 0 0 24 [[615, 874]] 1.0 4oti AGC_PKN1_HUMAN AGC 2e-90 308.4 1 260 260 757 758 759 761 763 644 663 667 737 739 738 740 797 785 780 779 778 777 776 775 774 696 Serine/threonine-protein kinase N1
AGC PKN2 PKN2_HUMAN 4CRSA Q16513 646 984 984.0 AGS:61985 ATPlike Inactive DFGin 6.156 12.763 BLAminus DFGAsp-rot-in -120.55, 175.31 66.4, 80.82 190.55, 2.52 -96.2, 27.19 310.22, 114.46 -62.58, -30.59 in-in in 9.266 Saltbr-in 2.748 HRD-in -80.04, -60.18 72.41, -11.14 in-in-out SNCiio in-out ActLoopNT-in 2.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.69, 159.24 APE9-dihe-na 123.16, -174.45 APE8-dihe-in -102.24, 141.6 APE8-rot-out 48.54 APE67-dihe-in -62.99, -37.09 -38.53, -44.47 APE12-dist-in 7.984 APE11-dist-in 11.144 APE10-dist-in 5.86 APE9-dist-in 4.12 None SEP755,TPO816,TPO958 SEP755,TPO816,TPO958 XRAY 2.75 0.213 0.262 A 341 332 0 0 0 0 [[657, 916]] 1.0 4crs AGC_PKN2_HUMAN AGC 1.2e-93 318.9 1 260 260 799 800 801 803 805 686 705 709 779 781 780 782 839 827 822 821 820 819 818 817 816 738 Serine/threonine-protein kinase N2
AGC PKN2 PKN2_HUMAN AF-Q16513-K1A Q16513 649 924 984.0 No_ligand No_ligand Active DFGin 6.179 12.729 BLAminus DFGAsp-rot-in -104.78, -164.2 32.17, 86.42 204.16, -1.05 -87.58, 14.2 304.86, 114.56 -62.49, -27.35 in-in in 9.006 Saltbr-in 2.648 HRD-in -83.07, -50.09 65.54, -0.41 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.04, 155.51 APE9-dihe-na 136.28, 173.3 APE8-dihe-in -75.79, 131.33 APE8-rot-in 298.91 APE67-dihe-in -68.12, -19.4 -47.06, -49.21 APE12-dist-in 8.485 APE11-dist-in 11.511 APE10-dist-in 5.853 APE9-dist-in 3.567 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[657, 916]] 1.0 AF-Q16513-K1 AGC_PKN2_HUMAN AGC 3.4e-95 324.0 1 260 260 799 800 801 803 805 686 705 709 779 781 780 782 839 827 822 821 820 819 818 817 816 738 Serine/threonine-protein kinase N2
AGC PKN2 PKN2_HUMAN AF-Q16513-K3A Q16513 649 924 984.0 No_ligand No_ligand Active DFGin 6.155 13.031 BLAminus DFGAsp-rot-in -110.59, -176.82 43.27, 87.9 204.69, 1.71 -86.69, 13.51 305.95, 120.87 -62.78, -28.87 in-in in 9.03 Saltbr-in 2.64 HRD-in -78.44, -51.01 68.76, 3.8 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.46, 154.22 APE9-dihe-na 132.16, 175.84 APE8-dihe-in -81.22, 133.36 APE8-rot-in 279.53 APE67-dihe-in -65.51, -20.27 -44.08, -52.92 APE12-dist-in 8.58 APE11-dist-in 11.4 APE10-dist-in 5.77 APE9-dist-in 3.406 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[657, 916]] 1.0 AF-Q16513-K3 AGC_PKN2_HUMAN AGC 3.4e-95 324.0 1 260 260 799 800 801 803 805 686 705 709 779 781 780 782 839 827 822 821 820 819 818 817 816 738 Serine/threonine-protein kinase N2
AGC PKN3 PKN3_HUMAN AF-Q6P5Z2-K1A Q6P5Z2 551 826 889.0 No_ligand No_ligand Active DFGin 6.213 12.713 BLAminus DFGAsp-rot-in -108.29, -162.23 28.36, 90.15 205.62, -1.39 -92.7, 15.89 303.19, 91.08 -64.78, -25.98 in-in in 8.816 Saltbr-in 2.676 HRD-in -86.48, -52.08 64.95, 2.74 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.84, 156.99 APE9-dihe-na 136.91, 173.5 APE8-dihe-in -75.44, 130.67 APE8-rot-in 299.0 APE67-dihe-in -68.06, -21.81 -47.48, -46.99 APE12-dist-in 8.511 APE11-dist-in 11.521 APE10-dist-in 5.87 APE9-dist-in 3.542 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[559, 818]] 1.0 AF-Q6P5Z2-K1 AGC_PKN3_HUMAN AGC 5.5e-88 300.4 1 260 260 701 702 703 705 707 588 607 611 681 683 682 684 741 729 724 723 722 721 720 719 718 640 Serine/threonine-protein kinase N3
AGC PKN3 PKN3_HUMAN AF-Q6P5Z2-K3A Q6P5Z2 551 826 889.0 No_ligand No_ligand Active DFGin 5.991 12.817 BLAminus DFGAsp-rot-in -113.6, -173.17 41.21, 88.04 206.31, -4.26 -90.03, 15.6 305.64, 101.61 -64.6, -27.59 in-in in 8.734 Saltbr-in 2.649 HRD-in -85.04, -52.23 68.56, 8.23 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.23, 154.67 APE9-dihe-na 136.51, -175.68 APE8-dihe-in -92.57, 130.9 APE8-rot-in 297.39 APE67-dihe-in -65.24, -22.49 -44.55, -51.17 APE12-dist-in 8.514 APE11-dist-in 11.482 APE10-dist-in 5.852 APE9-dist-in 3.352 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[559, 818]] 1.0 AF-Q6P5Z2-K3 AGC_PKN3_HUMAN AGC 5.5e-88 300.4 1 260 260 701 702 703 705 707 588 607 611 681 683 682 684 741 729 724 723 722 721 720 719 718 640 Serine/threonine-protein kinase N3
AGC PRKACA KAPCA_HUMAN 4AE6A P17612 13 351 351.0 No_ligand No_ligand Inactive DFGin 6.533 15.789 ABAminus DFGAsp-rot-in -102.0, -12.32 -149.9, 117.63 176.9, -0.3 -105.31, 23.09 271.72, 75.39 -56.8, -39.15 out-in out 10.065 Saltbr-in 3.037 HRD-in -80.45, -57.48 71.85, 11.08 in-in-out SNCiio in-out ActLoopNT-in 2.81 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.83, 165.09 APE9-dihe-na 109.71, 150.17 APE8-dihe-in -70.25, 136.52 APE8-rot-out 76.9 APE67-dihe-in -62.21, -26.49 -48.12, -39.36 APE12-dist-in 8.484 APE11-dist-in 11.62 APE10-dist-in 6.139 APE9-dist-in 4.249 None TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.219 0.283 A 343 321 0 0 0 0 [[44, 298]] 1.0 4ae6 AGC_PRKACA_HUMAN AGC 4.4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4AE6B P17612 17 351 351.0 No_ligand No_ligand Inactive DFGin 6.726 16.229 ABAminus DFGAsp-rot-in -110.11, -21.15 -129.5, 123.25 213.76, 74.12 -122.94, 15.22 289.43, 78.48 -49.18, -40.14 out-out out 10.478 Saltbr-out 4.404 HRD-in -72.54, -54.34 51.9, 34.46 out-in-out SNCoio in-out ActLoopNT-in 2.698 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.57, 163.72 APE9-dihe-na 111.27, 158.24 APE8-dihe-in -83.25, 146.52 APE8-rot-out 46.71 APE67-dihe-in -47.41, -26.35 -55.51, -46.4 APE12-dist-in 8.738 APE11-dist-in 11.441 APE10-dist-in 5.907 APE9-dist-in 4.36 None TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.219 0.283 B 343 323 0 0 0 0 [[44, 298]] 1.0 4ae6 AGC_PRKACA_HUMAN AGC 4.4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4AE9A P17612 13 351 351.0 No_ligand No_ligand Inactive DFGin 6.55 16.001 ABAminus DFGAsp-rot-in -108.08, 1.25 -143.04, 135.02 204.33, -87.0 -120.31, 26.17 277.62, 67.12 -50.31, -36.29 out-out out 10.202 Saltbr-out 4.928 HRD-in -78.87, -60.3 78.37, 10.3 out-in-in SNCoii in-in ActLoopNT-in 2.747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.01, 163.39 APE9-dihe-na 112.23, 171.54 APE8-dihe-in -84.52, 127.75 APE8-rot-in 289.6 APE67-dihe-in -56.88, -27.79 -43.6, -44.81 APE12-dist-in 8.27 APE11-dist-in 11.576 APE10-dist-in 6.027 APE9-dist-in 4.158 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.201 0.264 A 343 324 0 0 0 0 [[44, 298]] 1.0 4ae9 AGC_PRKACA_HUMAN AGC 4.4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4AE9B P17612 16 351 351.0 No_ligand No_ligand Inactive DFGin 6.749 16.161 ABAminus DFGAsp-rot-in -114.92, -7.43 -130.92, 125.97 212.38, -77.73 -130.48, 16.95 295.44, 81.38 -52.61, -39.79 out-out out 10.668 Saltbr-out 4.44 HRD-in -74.27, -49.34 44.92, 35.44 out-in-out SNCoio in-out ActLoopNT-in 2.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.93, 157.79 APE9-dihe-na 109.15, 156.62 APE8-dihe-in -68.62, 140.66 APE8-rot-out 10.98 APE67-dihe-in -51.62, -27.57 -42.37, -51.96 APE12-dist-in 8.547 APE11-dist-in 11.495 APE10-dist-in 5.926 APE9-dist-in 4.357 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.201 0.264 B 343 324 0 0 0 0 [[44, 298]] 1.0 4ae9 AGC_PRKACA_HUMAN AGC 4.4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 7Y1GB P17612 15 351 351.0 I5G:60401 Type1 Inactive DFGin 6.502 15.373 ABAminus DFGAsp-rot-out -112.68, -38.34 -99.79, 125.89 287.35, 55.1 -136.28, 17.99 282.52, 84.22 -66.37, -34.78 in-in in 9.45 Saltbr-in 2.869 HRD-in -80.77, -61.43 56.8, 33.17 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.12, 157.52 APE9-dihe-na 119.76, 163.27 APE8-dihe-in -78.91, 145.18 APE8-rot-out 49.01 APE67-dihe-in -67.8, -20.12 -41.99, -42.68 APE12-dist-in 8.186 APE11-dist-in 11.31 APE10-dist-in 5.752 APE9-dist-in 4.301 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.188 0.237 B 351 337 0 0 0 0 [[44, 298]] 1.0 7y1g AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9DC6A P17612 16 351 351.0 A1A3I:60501 Type1 Inactive DFGin 5.822 14.382 ABAminus DFGAsp-rot-in -129.15, -5.99 -129.24, 116.18 179.5, 78.2 -111.87, 19.13 279.15, 62.12 -54.37, -20.22 in-in in 9.109 Saltbr-in 3.309 HRD-in -90.78, -41.18 70.14, 8.35 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.59, -177.06 APE9-dihe-na 91.67, -156.82 APE8-dihe-in -118.5, 121.2 APE8-rot-in 293.95 APE67-dihe-in -55.19, -30.52 -37.8, -52.71 APE12-dist-in 8.237 APE11-dist-in 11.508 APE10-dist-in 6.105 APE9-dist-in 3.655 None SEP140,TPO198 SEP140,TPO198 XRAY 2.7 0.237 0.311 A 405 336 0 0 0 0 [[44, 298]] 1.0 9dc6 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9DC6B P17612 16 351 351.0 A1A3I:60501 Type1 Inactive DFGin 6.126 14.224 ABAminus DFGAsp-rot-in -118.96, -25.57 -111.81, 119.46 174.24, 64.8 -118.82, 27.48 291.58, 78.19 -62.06, -32.01 in-in in 8.967 Saltbr-in 2.88 HRD-in -75.88, -55.9 87.72, 2.66 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.71, 171.27 APE9-dihe-na 114.33, -156.38 APE8-dihe-in -127.33, 134.71 APE8-rot-in 292.26 APE67-dihe-in -63.06, -23.33 -44.45, -51.67 APE12-dist-in 8.533 APE11-dist-in 11.612 APE10-dist-in 6.073 APE9-dist-in 3.544 None SEP140,TPO198 SEP140,TPO198 XRAY 2.7 0.237 0.311 B 405 336 0 0 0 0 [[44, 298]] 1.0 9dc6 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AMBA P17612 4 351 351.0 VX6:60351 Type1 Inactive DFGin 5.087 14.292 ABAminus DFGAsp-rot-in -95.17, -47.0 -99.94, 115.14 192.53, -16.21 -101.01, 17.86 279.8, 67.75 -53.93, -36.65 in-in in 9.416 Saltbr-in 2.787 HRD-in -85.39, -50.26 66.81, 7.13 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.26, 159.46 APE9-dihe-na 131.88, -164.87 APE8-dihe-in -118.92, 127.93 APE8-rot-in 300.49 APE67-dihe-in -60.18, -24.15 -37.91, -53.92 APE12-dist-in 8.195 APE11-dist-in 11.58 APE10-dist-in 6.013 APE9-dist-in 3.641 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.25 0.214 0.256 A 351 343 0 0 0 0 [[44, 298]] 1.0 3amb AGC_PRKACA_HUMAN AGC 8.1e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8X5LA P17612 17 351 351.0 RKD:401 Type1 Inactive DFGin 4.104 12.291 ABAminus DFGAsp-rot-out -92.81, -18.04 -108.82, 165.79 313.73, -60.69 -131.86, 13.05 303.97, 96.56 69.26, -154.62 in-out in 9.959 Saltbr-out 4.157 HRD-in -67.69, -44.07 75.82, -80.8 out-out-out SNCooo out-out ActLoopNT-out 7.148 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.04, -32.9 APE9-dihe-na -87.77, -44.9 APE8-dihe-in -124.02, 60.68 APE8-rot-out 58.39 APE67-dihe-in -63.73, -18.25 -72.69, -25.11 APE12-dist-in 12.26 APE11-dist-out 15.76 APE10-dist-out 19.616 APE9-dist-out 13.59 None SEP339 SEP339 XRAY 2.75 0.204 0.255 A 352 331 4 0 0 4 [[44, 298]] 1.0 8x5l AGC_PRKACA_HUMAN AGC 8.2e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8X5LB P17612 17 334 351.0 RKD:401 Type1 Inactive DFGin 4.088 12.483 ABAminus DFGAsp-rot-out -93.45, -16.52 -108.91, 166.44 313.57, -61.04 -130.77, 10.4 300.78, 83.16 68.88, -158.2 out-out out 10.672 Saltbr-out 4.461 HRD-in -67.44, -44.97 74.27, -77.51 out-out-out SNCooo out-out ActLoopNT-out 7.167 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -62.33, 89.14 APE9-dihe-na -96.13, -167.24 APE8-dihe-in -45.35, 129.26 APE8-rot-out 58.75 APE67-dihe-in -60.15, -17.0 -69.42, -27.93 APE12-dist-in 9.293 APE11-dist-in 11.233 APE10-dist-out 15.051 APE9-dist-out 8.332 None SEP339 SEP339 XRAY 2.75 0.204 0.255 B 352 306 5 0 0 5 [[44, 298]] 1.0 8x5l AGC_PRKACA_HUMAN AGC 8.2e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.684 14.414 BLAminus DFGAsp-rot-in -121.45, -177.2 62.67, 77.75 196.78, -6.91 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.913 Saltbr-in 2.759 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.098 APE11-dist-in 11.392 APE10-dist-in 5.827 APE9-dist-in 3.498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337 336 0 0 0 0 [[44, 298]] 1.0 4wb8 AGC_PRKACA_HUMAN AGC 4.1e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.6 14.452 BLAminus DFGAsp-rot-in -123.05, 176.84 68.94, 80.02 197.37, -7.71 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.03 Saltbr-in 2.715 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.012 APE11-dist-in 11.4 APE10-dist-in 5.799 APE9-dist-in 3.567 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb5 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E P17612 13 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.934 14.165 BLAminus DFGAsp-rot-in -118.71, 175.9 64.55, 75.01 193.8, -1.22 -86.85, 19.7 273.68, 51.02 -43.49, -41.12 in-out in 9.419 Saltbr-out 5.456 HRD-in -91.66, -53.62 73.72, 11.47 out-in-in SNCoii in-in ActLoopNT-in 3.164 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.9, 150.23 APE9-dihe-na 149.21, -142.3 APE8-dihe-in -132.1, 131.95 APE8-rot-in 297.19 APE67-dihe-in -64.62, -25.64 -37.25, -53.79 APE12-dist-in 8.056 APE11-dist-in 10.984 APE10-dist-in 5.748 APE9-dist-in 3.216 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 E 350 339 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G P17612 15 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.036 14.084 BLAminus DFGAsp-rot-in -118.68, 176.55 65.34, 76.32 194.07, -1.19 -85.78, 18.75 273.72, 51.07 -44.34, -41.82 in-out in 9.713 Saltbr-out 5.215 HRD-in -91.95, -53.38 74.11, 11.57 out-in-in SNCoii in-in ActLoopNT-in 3.302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 149.81 APE9-dihe-na 148.91, -142.4 APE8-dihe-in -132.18, 131.68 APE8-rot-in 297.12 APE67-dihe-in -64.98, -25.0 -37.42, -54.32 APE12-dist-in 7.668 APE11-dist-in 10.658 APE10-dist-in 5.553 APE9-dist-in 3.41 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 G 350 337 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.445 14.649 BLAminus DFGAsp-rot-in -119.06, -174.39 59.4, 77.28 195.74, -3.82 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.87 Saltbr-in 2.769 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.18 APE11-dist-in 11.54 APE10-dist-in 5.955 APE9-dist-in 3.723 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.38 14.712 BLAminus DFGAsp-rot-in -115.93, -176.79 62.38, 75.33 194.29, -4.22 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.962 Saltbr-in 2.773 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.198 APE11-dist-in 11.563 APE10-dist-in 5.97 APE9-dist-in 3.642 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.626 14.616 BLAminus DFGAsp-rot-in -128.29, 177.03 62.06, 86.64 183.58, 14.0 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.808 Saltbr-in 3.196 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.734 APE11-dist-in 11.076 APE10-dist-in 5.63 APE9-dist-in 3.491 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.679 14.34 BLAminus DFGAsp-rot-in -129.89, 172.29 61.76, 74.25 173.55, 39.57 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.733 Saltbr-in 2.498 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.316 APE11-dist-in 11.106 APE10-dist-in 5.767 APE9-dist-in 3.618 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.626 13.772 BLAminus DFGAsp-rot-in -125.61, -173.52 60.53, 69.6 195.3, -1.08 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.129 Saltbr-in 3.0 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.14 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.999 APE11-dist-in 11.111 APE10-dist-in 5.797 APE9-dist-in 3.748 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edc AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 7.642 15.48 BLAminus DFGAsp-rot-in -131.38, -176.44 56.47, 73.0 198.32, -5.31 -86.17, 32.62 269.53, 53.11 -62.17, -29.29 in-out in 9.617 Saltbr-out 3.947 HRD-in -100.83, -51.39 64.03, -2.2 out-out-out SNCooo out-out ActLoopNT-out 3.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.87, 141.16 APE9-dihe-na 150.41, -172.01 APE8-dihe-in -103.27, 147.74 APE8-rot-out 185.24 APE67-dihe-in -92.0, 3.92 -57.96, -27.57 APE12-dist-in 8.165 APE11-dist-in 11.275 APE10-dist-in 5.628 APE9-dist-in 4.227 None TPO198,SEP339 TPO198,SEP339 EM 6.3 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edd AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 6.692 15.188 BLAminus DFGAsp-rot-in -131.57, -176.8 59.06, 65.59 199.64, -6.67 -87.14, 28.49 267.05, 50.71 -66.29, -36.64 in-out in 9.922 Saltbr-out 4.682 HRD-in -115.21, -49.18 64.38, 4.15 out-out-out SNCooo out-out ActLoopNT-out 3.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.67, 141.1 APE9-dihe-na 158.89, -177.66 APE8-dihe-in -75.58, 154.98 APE8-rot-out 190.35 APE67-dihe-in -109.16, -25.21 -65.33, -8.36 APE12-dist-in 8.347 APE11-dist-in 11.783 APE10-dist-in 6.829 APE9-dist-in 4.918 None TPO198,SEP339 TPO198,SEP339 EM 5.9 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9ede AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.068 14.398 BLAminus DFGAsp-rot-in -118.38, -169.49 51.77, 82.47 196.99, -10.62 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.83 Saltbr-in 2.561 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.046 APE11-dist-in 11.764 APE10-dist-in 6.243 APE9-dist-in 3.767 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.8e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.872 14.073 BLAminus DFGAsp-rot-in -117.82, -168.32 53.27, 78.35 192.68, -12.16 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.687 Saltbr-in 2.75 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.617 APE10-dist-in 6.204 APE9-dist-in 3.822 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350 343 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.8e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5IZJA P17612 15 351 351.0 6J9:60414 Allosteric Inactive DFGin 6.006 14.882 BLAminus DFGAsp-rot-in -111.62, 172.78 70.98, 87.77 198.16, -21.32 -97.8, 27.11 278.83, 80.41 -58.58, -30.48 in-out in 9.939 Saltbr-out 4.182 HRD-in -81.12, -50.89 44.27, 35.23 out-in-out SNCoio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.79, 157.34 APE9-dihe-na 106.02, 164.59 APE8-dihe-in -74.04, 136.38 APE8-rot-out 204.5 APE67-dihe-in -57.37, -26.41 -46.69, -44.98 APE12-dist-in 8.202 APE11-dist-in 11.523 APE10-dist-in 5.798 APE9-dist-in 4.225 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.199 0.226 A 351 330 0 0 0 0 [[44, 298]] 1.0 5izj AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5IZJB P17612 15 351 351.0 6J9:60413 Allosteric Inactive DFGin 6.201 15.274 BLAminus DFGAsp-rot-in -109.02, 168.97 75.33, 87.97 192.89, -11.26 -97.67, 24.22 269.13, 57.46 -63.02, -24.98 out-out out 10.289 Saltbr-out 4.543 HRD-in -78.48, -51.65 67.16, 12.35 out-in-out SNCoio in-out ActLoopNT-in 2.909 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.15, 157.15 APE9-dihe-na 105.13, 166.26 APE8-dihe-in -75.85, 137.43 APE8-rot-out 200.52 APE67-dihe-in -61.79, -25.86 -47.32, -41.18 APE12-dist-in 8.257 APE11-dist-in 11.483 APE10-dist-in 5.813 APE9-dist-in 4.069 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.199 0.226 B 351 327 0 0 0 0 [[44, 298]] 1.0 5izj AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5J5XA P17612 10 351 351.0 6J9:60404 Allosteric Active DFGin 6.131 14.267 BLAminus DFGAsp-rot-in -130.51, 173.14 68.75, 93.05 211.2, -45.33 -105.74, 27.05 279.27, 61.24 -64.37, -20.92 in-in in 8.495 Saltbr-in 2.736 HRD-in -82.45, -52.91 66.97, 1.69 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.53, 148.7 APE9-dihe-na 119.01, 165.11 APE8-dihe-in -70.44, 134.99 APE8-rot-in 296.24 APE67-dihe-in -60.26, -38.48 -54.53, -34.6 APE12-dist-in 7.811 APE11-dist-in 11.133 APE10-dist-in 5.601 APE9-dist-in 3.989 None TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.24 0.309 A 351 342 0 0 0 0 [[44, 298]] 1.0 5j5x AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN AF-P17612-K1A P17612 36 306 351.0 No_ligand No_ligand Active DFGin 5.955 14.101 BLAminus DFGAsp-rot-in -112.06, -162.49 41.01, 73.74 200.88, 17.4 -80.57, 22.27 279.02, 69.01 -57.23, -32.63 in-in in 8.73 Saltbr-in 2.607 HRD-in -81.22, -48.08 66.27, 5.12 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.31, 161.49 APE9-dihe-na 113.97, -179.99 APE8-dihe-in -91.88, 135.09 APE8-rot-in 302.21 APE67-dihe-in -65.91, -23.79 -48.59, -45.69 APE12-dist-in 8.056 APE11-dist-in 11.478 APE10-dist-in 5.716 APE9-dist-in 3.496 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P17612-K1 AGC_PRKACA_HUMAN AGC 1.9e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN AF-P17612-K3A P17612 36 306 351.0 No_ligand No_ligand Active DFGin 5.989 14.182 BLAminus DFGAsp-rot-in -127.06, -175.23 47.34, 85.15 204.74, -16.87 -88.29, 17.62 289.75, 82.76 -56.25, -31.52 in-in in 8.798 Saltbr-in 2.649 HRD-in -85.43, -51.15 69.13, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.07, 161.67 APE9-dihe-na 110.83, -179.43 APE8-dihe-in -90.4, 132.09 APE8-rot-in 300.17 APE67-dihe-in -66.95, -21.36 -48.38, -45.21 APE12-dist-in 8.072 APE11-dist-in 11.156 APE10-dist-in 5.49 APE9-dist-in 3.416 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P17612-K3 AGC_PRKACA_HUMAN AGC 1.9e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYSA P17612 14 351 351.0 No_ligand No_ligand Inactive DFGin 5.644 12.845 BLAminus DFGAsp-rot-in 176.97, -168.6 35.04, 63.97 228.7, -19.98 -77.13, -0.55 257.78, 43.58 -51.31, -30.32 in-out in 8.413 Saltbr-out 3.694 HRD-out -132.08, 139.02 -123.89, -19.92 out-in-in SNCoii in-in ActLoopNT-in 3.104 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.55, -174.54 APE9-dihe-na 119.07, -153.65 APE8-dihe-in -123.63, 121.24 APE8-rot-in 279.88 APE67-dihe-in -80.36, -3.37 -55.82, -41.73 APE12-dist-in 8.637 APE11-dist-in 11.063 APE10-dist-in 6.146 APE9-dist-in 3.491 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 4.75 0.216 0.255 A 350 338 0 0 0 0 [[44, 298]] 1.0 6bys AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYSC P17612 14 351 351.0 No_ligand No_ligand Inactive DFGin 5.6 13.017 BLAminus DFGAsp-rot-in 177.41, -169.47 35.75, 66.26 210.59, -1.33 -79.08, -7.92 257.89, 46.49 -37.01, -39.99 in-out in 8.431 Saltbr-out 3.631 HRD-out -132.47, 138.88 -123.68, -21.42 out-in-in SNCoii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.21, -176.06 APE9-dihe-na 122.36, -150.78 APE8-dihe-in -124.74, 121.46 APE8-rot-in 280.04 APE67-dihe-in -74.72, -2.75 -56.12, -45.35 APE12-dist-in 8.621 APE11-dist-in 11.03 APE10-dist-in 6.17 APE9-dist-in 3.555 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 4.75 0.216 0.255 C 350 338 0 0 0 0 [[44, 298]] 1.0 6bys AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYSE P17612 14 351 351.0 No_ligand No_ligand Inactive DFGin 5.599 12.778 BLAminus DFGAsp-rot-in 177.63, -170.33 35.66, 68.12 228.05, -19.68 -82.89, -7.7 254.73, 43.9 -34.72, -39.61 in-in in 8.395 Saltbr-in 3.53 HRD-out -134.25, 137.62 -124.05, -19.61 in-in-in SNCiii in-in ActLoopNT-in 3.134 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -175.91, -174.99 APE9-dihe-na 120.1, -152.87 APE8-dihe-in -123.78, 120.18 APE8-rot-in 279.49 APE67-dihe-in -74.6, -2.18 -55.44, -46.05 APE12-dist-in 8.526 APE11-dist-in 11.009 APE10-dist-in 6.158 APE9-dist-in 3.492 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 4.75 0.216 0.255 E 350 338 0 0 0 0 [[44, 298]] 1.0 6bys AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYSG P17612 14 351 351.0 No_ligand No_ligand Inactive DFGin 5.55 12.88 BLAminus DFGAsp-rot-in 177.64, -169.59 35.17, 69.18 229.54, -21.77 -84.06, -7.89 253.42, 50.51 -34.53, -40.01 in-out in 8.406 Saltbr-out 3.604 HRD-out -131.78, 137.89 -122.99, -20.45 out-in-in SNCoii in-in ActLoopNT-in 3.091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.78, -177.53 APE9-dihe-na 124.08, -149.25 APE8-dihe-in -124.03, 121.23 APE8-rot-in 280.42 APE67-dihe-in -73.41, -1.98 -56.98, -46.28 APE12-dist-in 8.617 APE11-dist-in 11.077 APE10-dist-in 6.151 APE9-dist-in 3.543 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 4.75 0.216 0.255 G 350 338 0 0 0 0 [[44, 298]] 1.0 6bys AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7A P17612 16 351 351.0 No_ligand No_ligand Inactive DFGin 6.583 14.551 BLAminus DFGAsp-rot-in -119.16, 176.65 65.47, 76.79 194.39, -1.33 -85.63, 19.52 273.14, 48.34 -44.12, -41.29 in-out in 9.256 Saltbr-out 3.837 HRD-in -93.59, -54.13 73.95, 11.29 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.66, 149.89 APE9-dihe-na 148.72, -142.64 APE8-dihe-in -132.35, 131.6 APE8-rot-in 297.3 APE67-dihe-in -65.08, -25.39 -37.56, -54.33 APE12-dist-in 7.857 APE11-dist-in 10.735 APE10-dist-in 5.368 APE9-dist-in 3.311 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 A 350 336 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7C P17612 12 351 351.0 No_ligand No_ligand Active DFGin 5.309 14.041 BLAminus DFGAsp-rot-in -119.31, 176.37 65.24, 77.94 194.93, -1.32 -84.43, 19.43 273.37, 51.07 -43.97, -41.52 in-in in 8.987 Saltbr-in 2.36 HRD-in -94.38, -54.81 73.77, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.7, 149.95 APE9-dihe-na 149.29, -142.75 APE8-dihe-in -132.31, 130.88 APE8-rot-in 297.15 APE67-dihe-in -65.36, -25.54 -38.33, -55.04 APE12-dist-in 8.372 APE11-dist-in 10.863 APE10-dist-in 5.572 APE9-dist-in 3.16 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 C 350 340 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGMA P17612 13 351 351.0 No_ligand No_ligand Active DFGin 6.446 13.402 BLAminus DFGAsp-rot-in -121.71, 165.51 70.43, 93.14 197.46, -19.7 -102.22, 24.88 291.91, 69.39 -56.91, -34.43 in-in in 8.76 Saltbr-in 2.802 HRD-in -90.0, -49.9 65.54, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 155.53 APE9-dihe-na 129.13, -155.89 APE8-dihe-in -119.08, 128.77 APE8-rot-in 315.26 APE67-dihe-in -58.72, -28.41 -42.89, -48.17 APE12-dist-in 7.962 APE11-dist-in 11.34 APE10-dist-in 5.789 APE9-dist-in 3.839 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.277 0.265 A 351 339 0 0 0 0 [[44, 298]] 1.0 3agm AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5IZFA P17612 14 351 351.0 No_ligand No_ligand Active DFGin 6.469 14.681 BLAminus DFGAsp-rot-in -115.33, 168.85 66.79, 92.72 197.91, -8.29 -104.07, 26.57 271.02, 67.91 -60.32, -26.19 in-in in 8.92 Saltbr-in 2.86 HRD-in -91.12, -53.12 70.24, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 154.6 APE9-dihe-na 132.55, -178.51 APE8-dihe-in -93.41, 131.47 APE8-rot-in 300.25 APE67-dihe-in -61.6, -25.88 -48.77, -44.1 APE12-dist-in 7.999 APE11-dist-in 11.651 APE10-dist-in 5.984 APE9-dist-in 4.143 None TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.232 0.27 A 351 338 0 0 0 0 [[44, 298]] 1.0 5izf AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3MVJB P17612 16 351 351.0 No_ligand No_ligand Inactive DFGin 6.675 15.072 BLAminus DFGAsp-rot-in -107.29, 175.17 69.85, 103.13 216.92, -44.71 -126.62, 31.7 289.12, 86.96 -68.94, -36.62 in-out in 9.862 Saltbr-out 5.181 HRD-in -72.7, -45.04 65.83, 8.62 out-in-in SNCoii in-in ActLoopNT-in 2.682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.22, 164.94 APE9-dihe-na 113.67, -166.87 APE8-dihe-in -95.86, 130.98 APE8-rot-in 290.81 APE67-dihe-in -63.62, -17.9 -44.08, -47.61 APE12-dist-in 8.45 APE11-dist-in 11.532 APE10-dist-in 6.273 APE9-dist-in 4.219 None TPO198,SEP339 TPO198,SEP339 XRAY 2.49 0.217 0.304 B 371 322 0 0 0 0 [[44, 298]] 1.0 3mvj AGC_PRKACA_HUMAN AGC 5.6e-95 323.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3NX8A P17612 16 351 351.0 No_ligand No_ligand Active DFGin 6.217 14.321 BLAminus DFGAsp-rot-in -121.41, 174.36 68.59, 92.57 202.99, -30.78 -100.19, 21.71 266.05, 56.03 -54.66, -29.9 in-in in 8.867 Saltbr-in 3.095 HRD-in -83.14, -56.31 66.43, 12.16 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.5, 160.02 APE9-dihe-na 128.98, -158.22 APE8-dihe-in -117.99, 132.74 APE8-rot-in 294.49 APE67-dihe-in -53.23, -32.68 -47.46, -50.82 APE12-dist-in 8.049 APE11-dist-in 11.428 APE10-dist-in 5.853 APE9-dist-in 3.626 None TPO198,SEP339 TPO198,LGY293,SEP339 XRAY 2.0 0.22 0.288 A 351 336 0 0 0 0 [[44, 298]] 1.0 3nx8 AGC_PRKACA_HUMAN AGC 3e-94 321.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6WJFA P17612 2 351 351.0 No_ligand No_ligand Inactive DFGin 9.999 13.483 BLAminus DFGAsp-rot-in -126.44, 169.73 60.01, 89.86 193.79, -0.12 -112.86, 1.12 296.86, 95.65 -61.53, -29.79 out-out out 10.091 Saltbr-out 7.235 HRD-in -67.55, -42.01 64.88, -66.83 out-out-out SNCooo out-out ActLoopNT-out 3.687 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -171.91, 116.67 APE9-dihe-na 154.02, -66.34 APE8-dihe-in -113.18, 77.77 APE8-rot-out 47.03 APE67-dihe-in -82.77, -55.57 -68.63, -38.53 APE12-dist-in 8.481 APE11-dist-in 12.04 APE10-dist-in 7.815 APE9-dist-in 4.446 None None None EM 7.5 999.0 999.0 A 405 336 0 0 0 0 [[44, 298]] 1.0 6wjf AGC_PRKACA_HUMAN AGC 3.4e-94 320.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6WJFB P17612 42 351 351.0 No_ligand No_ligand Inactive DFGin 10.053 15.229 BLAminus DFGAsp-rot-in -124.34, 176.36 59.38, 90.58 191.47, 7.84 -123.09, 12.38 277.22, 94.34 -61.71, -29.6 out-out out 11.687 Saltbr-out 6.431 HRD-out -65.49, -35.93 66.74, -107.09 out-out-out SNCooo out-out ActLoopNT-out 3.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -163.85, -158.9 APE9-dihe-na 100.21, -130.3 APE8-dihe-in -150.47, 147.99 APE8-rot-out 180.18 APE67-dihe-in -80.92, 5.22 -58.41, -26.93 APE12-dist-in 8.681 APE11-dist-in 11.766 APE10-dist-in 6.795 APE9-dist-out 6.3 None None None EM 7.5 999.0 999.0 B 405 310 27 0 0 0 [[44, 298]] 1.0 6wjf AGC_PRKACA_HUMAN AGC 3.4e-94 320.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6WJGA P17612 42 351 351.0 No_ligand No_ligand Inactive DFGin 9.999 13.483 BLAminus DFGAsp-rot-in -126.44, 169.73 60.01, 89.86 193.79, -0.12 -112.86, 1.12 296.86, 95.65 -61.53, -29.79 out-out out 10.091 Saltbr-out 7.235 HRD-in -67.55, -42.01 64.88, -66.83 out-out-out SNCooo out-out ActLoopNT-out 3.687 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -171.91, 116.67 APE9-dihe-na 154.02, -66.34 APE8-dihe-in -113.18, 77.77 APE8-rot-out 47.03 APE67-dihe-in -82.77, -55.57 -68.63, -38.53 APE12-dist-in 8.481 APE11-dist-in 12.04 APE10-dist-in 7.815 APE9-dist-in 4.446 None None None EM 6.2 999.0 999.0 A 405 310 27 0 0 0 [[44, 298]] 1.0 6wjg AGC_PRKACA_HUMAN AGC 3.4e-94 320.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6WJGB P17612 42 351 351.0 No_ligand No_ligand Inactive DFGin 10.053 15.229 BLAminus DFGAsp-rot-in -124.34, 176.36 59.38, 90.58 191.47, 7.84 -123.09, 12.38 277.22, 94.34 -61.71, -29.6 out-out out 11.687 Saltbr-out 6.431 HRD-out -65.49, -35.93 66.74, -107.09 out-out-out SNCooo out-out ActLoopNT-out 3.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -163.85, -158.9 APE9-dihe-na 100.21, -130.3 APE8-dihe-in -150.47, 147.99 APE8-rot-out 180.18 APE67-dihe-in -80.92, 5.22 -58.41, -26.93 APE12-dist-in 8.681 APE11-dist-in 11.766 APE10-dist-in 6.795 APE9-dist-out 6.3 None None None EM 6.2 999.0 999.0 B 405 310 27 0 0 0 [[44, 298]] 1.0 6wjg AGC_PRKACA_HUMAN AGC 3.4e-94 320.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9DCDA P17612 14 351 351.0 A1A3J:60401 Type1 Active DFGin 5.929 14.45 BLAminus DFGAsp-rot-in -126.13, 173.68 64.63, 91.94 197.49, -17.64 -99.88, 28.46 273.99, 56.84 -61.81, -26.4 in-in in 9.125 Saltbr-in 2.729 HRD-in -91.13, -53.48 71.25, 11.66 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.7, 158.74 APE9-dihe-na 136.61, -155.83 APE8-dihe-in -120.28, 133.14 APE8-rot-in 302.66 APE67-dihe-in -56.79, -23.93 -44.41, -54.9 APE12-dist-in 8.029 APE11-dist-in 11.442 APE10-dist-in 5.913 APE9-dist-in 3.617 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.7 0.174 0.191 A 350 338 0 0 0 0 [[44, 298]] 1.0 9dcd AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGLA P17612 11 351 351.0 A03:60351 Type1 Active DFGin 6.145 14.187 BLAminus DFGAsp-rot-in -123.32, 177.62 64.25, 83.52 198.9, -10.58 -96.46, 22.51 272.11, 61.62 -58.64, -28.46 in-in in 8.491 Saltbr-in 2.886 HRD-in -82.44, -53.5 74.32, 9.67 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.19, 166.18 APE9-dihe-na 128.76, -154.1 APE8-dihe-in -126.1, 126.27 APE8-rot-in 292.64 APE67-dihe-in -59.45, -23.51 -43.73, -52.47 APE12-dist-in 8.09 APE11-dist-in 11.285 APE10-dist-in 5.642 APE9-dist-in 3.692 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.2 0.237 A 351 341 0 0 0 0 [[44, 298]] 1.0 3agl AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AGLB P17612 15 351 351.0 A03:60351 Type1 Active DFGin 6.244 14.259 BLAminus DFGAsp-rot-in -119.17, 172.99 64.04, 88.92 196.61, -12.73 -97.96, 24.36 271.27, 65.91 -60.24, -24.04 in-in in 8.483 Saltbr-in 2.838 HRD-in -81.23, -56.2 72.88, 10.89 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.17, 153.35 APE9-dihe-na 137.51, -153.25 APE8-dihe-in -122.43, 130.68 APE8-rot-in 303.24 APE67-dihe-in -59.0, -24.94 -49.14, -44.94 APE12-dist-in 8.082 APE11-dist-in 11.322 APE10-dist-in 5.744 APE9-dist-in 3.881 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.2 0.237 B 351 337 0 0 0 0 [[44, 298]] 1.0 3agl AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9LA P17612 12 351 351.0 L9L:60351 Type1 Active DFGin 6.686 14.585 BLAminus DFGAsp-rot-in -131.42, 170.84 67.14, 98.79 201.59, -25.27 -112.52, 31.48 281.78, 68.95 -76.6, -5.02 in-in in 9.118 Saltbr-in 3.022 HRD-in -66.86, -56.55 70.6, 11.25 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.79, 159.06 APE9-dihe-na 115.3, -161.08 APE8-dihe-in -112.72, 124.05 APE8-rot-in 306.01 APE67-dihe-in -58.13, -24.33 -29.04, -60.55 APE12-dist-in 8.35 APE11-dist-in 11.188 APE10-dist-in 5.587 APE9-dist-in 3.515 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.262 A 351 340 0 0 0 0 [[44, 298]] 1.0 3l9l AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9LB P17612 13 351 351.0 L9L:60351 Type1 Active DFGin 6.504 14.748 BLAminus DFGAsp-rot-in -126.06, 169.3 70.23, 93.91 198.58, -19.42 -105.72, 28.14 277.25, 72.68 -68.61, -5.61 in-in in 9.122 Saltbr-in 3.092 HRD-in -71.18, -54.73 64.89, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 167.34 APE9-dihe-na 115.39, -170.56 APE8-dihe-in -110.93, 132.83 APE8-rot-in 304.32 APE67-dihe-in -49.56, -29.7 -32.05, -69.65 APE12-dist-in 8.223 APE11-dist-in 11.294 APE10-dist-in 5.685 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.262 B 351 339 0 0 0 0 [[44, 298]] 1.0 3l9l AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OOGA P17612 17 351 351.0 YTP:62001 Type1 Active DFGin 5.897 14.324 BLAminus DFGAsp-rot-in -121.7, 177.27 65.88, 89.72 198.64, -14.4 -99.72, 18.72 271.46, 61.56 -55.08, -24.51 in-in in 9.092 Saltbr-in 2.564 HRD-in -88.93, -49.19 62.2, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.22, 156.24 APE9-dihe-na 130.48, -158.98 APE8-dihe-in -121.53, 132.57 APE8-rot-in 295.61 APE67-dihe-in -56.76, -31.12 -46.34, -49.72 APE12-dist-in 8.184 APE11-dist-in 11.561 APE10-dist-in 5.99 APE9-dist-in 3.782 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.276 A 351 335 0 0 0 0 [[44, 298]] 1.0 3oog AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OVVA P17612 15 351 351.0 1SB:62001 Type1 Active DFGin 5.695 14.513 BLAminus DFGAsp-rot-in -122.03, 173.75 63.75, 85.64 192.68, -15.9 -91.93, 24.88 270.34, 49.38 -58.53, -29.2 in-in in 9.157 Saltbr-in 2.643 HRD-in -85.42, -51.64 68.38, 18.21 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.97, 161.66 APE9-dihe-na 131.92, -151.97 APE8-dihe-in -126.88, 132.92 APE8-rot-in 299.89 APE67-dihe-in -61.32, -22.22 -45.4, -52.6 APE12-dist-in 8.128 APE11-dist-in 11.55 APE10-dist-in 5.907 APE9-dist-in 3.531 None TPO198,SEP339 TPO198,SEP339 XRAY 1.58 0.186 0.232 A 351 337 0 0 0 0 [[44, 298]] 1.0 3ovv AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OWPA P17612 16 351 351.0 2SB:62001 Type1 Active DFGin 5.797 14.577 BLAminus DFGAsp-rot-in -129.79, 179.44 68.22, 88.81 199.91, -15.39 -97.88, 23.63 269.47, 50.63 -59.8, -24.73 in-in in 9.021 Saltbr-in 2.648 HRD-in -91.6, -55.1 70.56, 10.08 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 156.32 APE9-dihe-na 133.26, -159.94 APE8-dihe-in -117.71, 131.95 APE8-rot-in 303.89 APE67-dihe-in -56.68, -26.5 -44.05, -53.81 APE12-dist-in 8.079 APE11-dist-in 11.53 APE10-dist-in 5.947 APE9-dist-in 3.825 None TPO198,SEP339 TPO198,SEP339 XRAY 1.88 0.172 0.211 A 351 336 0 0 0 0 [[44, 298]] 1.0 3owp AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3OXTA P17612 15 351 351.0 3SB:62001 Type1 Active DFGin 5.724 14.322 BLAminus DFGAsp-rot-in -130.49, 176.59 67.71, 88.75 205.31, -21.95 -96.86, 20.88 271.58, 55.14 -54.8, -35.77 in-in in 9.108 Saltbr-in 2.754 HRD-in -88.64, -56.71 72.64, 4.73 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.01, 154.62 APE9-dihe-na 133.52, -155.05 APE8-dihe-in -117.36, 129.13 APE8-rot-in 302.02 APE67-dihe-in -56.32, -26.92 -42.89, -52.47 APE12-dist-in 8.269 APE11-dist-in 11.861 APE10-dist-in 6.261 APE9-dist-in 4.109 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.176 0.239 A 351 337 0 0 0 0 [[44, 298]] 1.0 3oxt AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3P0MA P17612 15 351 351.0 4SB:60351 Type1 Active DFGin 5.923 14.578 BLAminus DFGAsp-rot-in -120.95, -179.03 59.8, 84.94 195.98, -7.43 -96.45, 19.28 269.08, 54.31 -49.85, -35.86 in-in in 9.001 Saltbr-in 2.66 HRD-in -87.41, -52.38 71.61, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.78, 160.64 APE9-dihe-na 131.62, -157.52 APE8-dihe-in -119.88, 133.57 APE8-rot-in 304.97 APE67-dihe-in -52.04, -26.97 -43.23, -57.05 APE12-dist-in 8.019 APE11-dist-in 11.477 APE10-dist-in 5.887 APE9-dist-in 3.658 None TPO198,SEP339 TPO198,SEP339 XRAY 2.03 0.171 0.205 A 351 337 0 0 0 0 [[44, 298]] 1.0 3p0m AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3POOA P17612 15 351 351.0 S69:62001 Type1 Active DFGin 5.688 14.66 BLAminus DFGAsp-rot-in -122.77, 177.28 59.44, 86.58 197.54, -7.06 -95.62, 24.37 267.18, 52.33 -56.67, -28.22 in-in in 9.226 Saltbr-in 2.614 HRD-in -88.33, -52.91 73.26, 10.11 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 158.93 APE9-dihe-na 133.77, -158.97 APE8-dihe-in -121.67, 134.24 APE8-rot-in 298.67 APE67-dihe-in -57.61, -22.88 -45.78, -52.79 APE12-dist-in 8.096 APE11-dist-in 11.527 APE10-dist-in 5.938 APE9-dist-in 3.556 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.187 0.212 A 351 333 0 0 0 0 [[44, 298]] 1.0 3poo AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3VQHA P17612 5 351 351.0 IQB:60401 Type1 Inactive DFGin 5.887 14.509 BLAminus DFGAsp-rot-out -116.4, -175.47 66.0, 75.68 285.06, -87.73 -94.16, 21.7 272.84, 60.82 -59.14, -31.37 in-in in 8.898 Saltbr-in 2.691 HRD-in -94.63, -51.76 70.89, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.13, 162.63 APE9-dihe-na 132.63, -148.92 APE8-dihe-in -128.75, 132.36 APE8-rot-in 300.65 APE67-dihe-in -61.72, -25.75 -46.04, -48.59 APE12-dist-in 8.058 APE11-dist-in 11.523 APE10-dist-in 5.842 APE9-dist-in 3.641 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.95 0.192 0.234 A 351 347 0 0 0 0 [[44, 298]] 1.0 3vqh AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4UJ1A P17612 15 351 351.0 NVX:61351 Type1 Inactive DFGin 6.242 14.547 BLAminus DFGAsp-rot-out -123.61, -163.8 61.68, 70.56 301.98, -51.12 -93.64, 20.6 271.48, 60.79 -64.78, -20.97 in-in in 9.038 Saltbr-in 2.552 HRD-in -90.63, -51.42 73.4, 9.87 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.01, 158.56 APE9-dihe-na 139.11, -156.28 APE8-dihe-in -125.77, 137.11 APE8-rot-in 295.71 APE67-dihe-in -57.89, -23.24 -51.45, -49.94 APE12-dist-in 8.12 APE11-dist-in 11.393 APE10-dist-in 5.867 APE9-dist-in 3.624 None TPO198,SEP339 TPO198,SEP339 XRAY 1.768 0.168 0.201 A 351 337 0 0 0 0 [[44, 298]] 1.0 4uj1 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4UJ2A P17612 15 351 351.0 NVV:61351 Type1 Inactive DFGin 6.381 14.57 BLAminus DFGAsp-rot-out -125.67, -160.4 61.32, 58.86 301.46, -27.71 -86.58, 22.47 272.1, 62.19 -53.53, -31.63 in-in in 9.078 Saltbr-in 2.641 HRD-in -86.14, -55.69 77.07, 9.76 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.59, 157.48 APE9-dihe-na 137.97, -154.25 APE8-dihe-in -126.65, 132.96 APE8-rot-in 298.62 APE67-dihe-in -53.02, -26.32 -44.15, -55.11 APE12-dist-in 8.245 APE11-dist-in 11.652 APE10-dist-in 6.117 APE9-dist-in 3.561 None TPO198,SEP339 TPO198,SEP339 XRAY 2.019 0.165 0.209 A 351 337 0 0 0 0 [[44, 298]] 1.0 4uj2 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4UJ9A P17612 11 351 351.0 S3N:61351 Type1 Inactive DFGin 6.134 14.65 BLAminus DFGAsp-rot-out -117.52, -171.14 58.79, 71.43 275.8, 84.66 -92.02, 19.19 269.08, 56.18 -56.86, -27.59 in-in in 8.92 Saltbr-in 2.506 HRD-in -93.86, -53.97 74.6, 12.42 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.92, 155.16 APE9-dihe-na 141.7, -146.62 APE8-dihe-in -127.44, 135.95 APE8-rot-in 296.91 APE67-dihe-in -56.69, -21.29 -47.92, -48.81 APE12-dist-in 7.952 APE11-dist-in 11.428 APE10-dist-in 5.848 APE9-dist-in 3.479 None TPO198,SEP339 TPO198,SEP339 XRAY 1.87 0.167 0.206 A 351 341 0 0 0 0 [[44, 298]] 1.0 4uj9 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4UJAA P17612 14 351 351.0 4L7:61351 Type1 Inactive DFGin 6.097 14.613 BLAminus DFGAsp-rot-out -125.31, -163.62 62.94, 64.42 298.29, -34.39 -88.89, 21.72 270.4, 58.9 -55.44, -30.93 in-in in 9.049 Saltbr-in 2.777 HRD-in -87.37, -51.28 70.71, 6.14 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.5, 162.38 APE9-dihe-na 130.88, -155.58 APE8-dihe-in -125.03, 133.85 APE8-rot-in 299.16 APE67-dihe-in -59.42, -24.42 -46.24, -50.45 APE12-dist-in 8.169 APE11-dist-in 11.513 APE10-dist-in 5.967 APE9-dist-in 3.589 None TPO198,SEP339 TPO198,SEP339 XRAY 1.93 0.166 0.206 A 351 338 0 0 0 0 [[44, 298]] 1.0 4uja AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4UJBA P17612 5 351 351.0 8BQ:61351 Type1 Inactive DFGin 5.947 14.668 BLAminus DFGAsp-rot-out -125.29, -162.0 58.42, 69.71 302.63, -24.89 -90.44, 19.28 267.91, 58.77 -53.57, -31.33 in-in in 9.135 Saltbr-in 2.743 HRD-in -89.96, -52.14 72.96, 12.71 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.56, 161.27 APE9-dihe-na 132.43, -159.75 APE8-dihe-in -122.62, 132.75 APE8-rot-in 302.43 APE67-dihe-in -59.14, -27.14 -46.68, -47.07 APE12-dist-in 8.138 APE11-dist-in 11.456 APE10-dist-in 5.942 APE9-dist-in 3.603 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.949 0.156 0.19 A 351 347 0 0 0 0 [[44, 298]] 1.0 4ujb AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5BX6A P17612 6 351 351.0 495:60401 Type1 Active DFGin 6.183 14.303 BLAminus DFGAsp-rot-in -119.55, 164.86 70.92, 91.57 197.89, -12.96 -100.18, 26.65 271.79, 52.76 -61.33, -23.25 in-in in 8.906 Saltbr-in 2.708 HRD-in -93.87, -50.75 70.32, 10.63 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.15, 164.21 APE9-dihe-na 125.51, -162.2 APE8-dihe-in -117.48, 134.41 APE8-rot-in 303.65 APE67-dihe-in -56.37, -27.52 -46.12, -51.63 APE12-dist-in 8.075 APE11-dist-in 11.455 APE10-dist-in 5.918 APE9-dist-in 3.601 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.89 0.172 0.218 A 351 346 0 0 0 0 [[44, 298]] 1.0 5bx6 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5BX7A P17612 6 350 351.0 4W1:60401 Type1 Active DFGin 5.893 14.257 BLAminus DFGAsp-rot-in -120.21, 170.97 66.4, 95.24 202.52, -17.27 -104.96, 26.38 271.55, 55.44 -58.59, -27.02 in-in in 8.887 Saltbr-in 2.646 HRD-in -91.82, -48.84 66.55, 10.61 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.67, 162.65 APE9-dihe-na 129.46, -159.53 APE8-dihe-in -119.63, 133.68 APE8-rot-in 305.25 APE67-dihe-in -56.25, -25.43 -45.01, -52.75 APE12-dist-in 8.11 APE11-dist-in 11.518 APE10-dist-in 5.961 APE9-dist-in 3.581 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.89 0.178 0.226 A 351 345 0 0 0 0 [[44, 298]] 1.0 5bx7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5UZKA P17612 15 351 351.0 504:60401 Type1 Active DFGin 6.381 13.948 BLAminus DFGAsp-rot-in -125.23, 159.32 70.49, 97.31 201.36, -17.78 -104.94, 23.81 281.36, 67.83 -60.03, -27.16 in-in in 8.88 Saltbr-in 2.765 HRD-in -81.16, -49.29 61.5, 17.59 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.44, 160.74 APE9-dihe-na 127.01, -154.99 APE8-dihe-in -117.26, 132.5 APE8-rot-in 297.37 APE67-dihe-in -55.36, -26.76 -39.46, -56.34 APE12-dist-in 8.011 APE11-dist-in 11.394 APE10-dist-in 5.83 APE9-dist-in 3.588 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.191 0.253 A 351 337 0 0 0 0 [[44, 298]] 1.0 5uzk AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6QJ7A P17612 14 351 351.0 J4B:60401 Type1 Active DFGin 6.371 14.879 BLAminus DFGAsp-rot-in -117.39, 169.65 69.58, 85.56 196.66, -4.98 -98.1, 21.35 272.03, 58.03 -54.77, -30.7 in-in in 9.214 Saltbr-in 2.75 HRD-in -87.29, -50.94 66.9, 9.43 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.01, 157.32 APE9-dihe-na 126.55, -163.63 APE8-dihe-in -112.81, 131.54 APE8-rot-in 300.45 APE67-dihe-in -57.75, -27.43 -43.16, -51.25 APE12-dist-in 8.004 APE11-dist-in 11.506 APE10-dist-in 5.846 APE9-dist-in 3.703 None TPO198,SEP339 TPO198,SEP339 XRAY 1.69 0.179 0.214 A 351 338 0 0 0 0 [[44, 298]] 1.0 6qj7 AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 7Y1GA P17612 16 351 351.0 I5G:60500 Type1 Inactive DFGin 6.341 14.862 BLAminus DFGAsp-rot-out -118.48, 174.7 76.77, 103.0 276.04, 59.02 -130.63, 13.32 288.1, 82.33 -55.62, -41.63 in-in in 9.112 Saltbr-in 2.716 HRD-in -77.78, -56.16 48.65, 33.18 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.96, 160.38 APE9-dihe-na 112.98, 149.31 APE8-dihe-in -54.34, 136.89 APE8-rot-out 199.98 APE67-dihe-in -67.35, -18.71 -49.9, -39.67 APE12-dist-in 8.118 APE11-dist-in 11.271 APE10-dist-in 5.634 APE9-dist-in 4.254 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.188 0.237 A 351 336 0 0 0 0 [[44, 298]] 1.0 7y1g AGC_PRKACA_HUMAN AGC 4.7e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6C0UA P17612 12 351 351.0 EE4:60400 Type1 Inactive DFGin 6.489 14.262 BLAminus DFGAsp-rot-in -130.77, 175.54 62.84, 100.35 201.61, -12.71 -119.36, 26.56 282.24, 71.26 -65.52, -23.67 in-in in 8.367 Saltbr-in 3.028 HRD-in -79.47, -53.84 70.3, 8.89 in-in-out SNCiio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.41, 153.98 APE9-dihe-na 116.73, 155.27 APE8-dihe-in -73.99, 144.03 APE8-rot-out 173.49 APE67-dihe-in -64.51, -15.31 -53.81, -42.18 APE12-dist-in 7.614 APE11-dist-in 10.848 APE10-dist-in 5.483 APE9-dist-in 3.935 None TPO198,SEP339 TPO198,SEP339 XRAY 2.65 0.211 0.243 A 354 340 0 0 0 0 [[44, 298]] 1.0 6c0u AGC_PRKACA_HUMAN AGC 4.8e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3MVJA P17612 16 351 351.0 XFE:60351 Type1 Active DFGin 6.188 13.582 BLAminus DFGAsp-rot-in -115.88, 169.36 72.34, 84.05 212.56, -48.08 -100.4, 21.07 284.54, 72.78 -48.33, -32.34 in-in in 8.693 Saltbr-in 2.943 HRD-in -94.45, -57.98 81.77, 7.12 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.5, 165.11 APE9-dihe-na 130.23, -153.23 APE8-dihe-in -130.91, 127.14 APE8-rot-in 305.92 APE67-dihe-in -54.4, -32.7 -46.27, -53.24 APE12-dist-in 8.165 APE11-dist-in 11.441 APE10-dist-in 5.835 APE9-dist-in 3.678 None TPO198,SEP339 TPO198,SEP339 XRAY 2.49 0.217 0.304 A 371 336 0 0 0 0 [[44, 298]] 1.0 3mvj AGC_PRKACA_HUMAN AGC 5.6e-95 323.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3MVJE P17612 16 351 351.0 XFE:60351 Type1 Active DFGin 6.01 13.904 BLAminus DFGAsp-rot-in -120.77, 173.49 75.79, 91.53 221.62, -16.98 -105.05, 22.03 286.9, 73.04 -48.68, -45.44 in-in in 8.786 Saltbr-in 2.504 HRD-in -85.62, -59.75 66.22, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.99, 156.89 APE9-dihe-na 143.78, -161.15 APE8-dihe-in -124.44, 132.79 APE8-rot-in 305.29 APE67-dihe-in -69.91, -25.33 -54.9, -34.25 APE12-dist-in 8.148 APE11-dist-in 11.447 APE10-dist-in 5.803 APE9-dist-in 3.801 None TPO198,SEP339 TPO198,SEP339 XRAY 2.49 0.217 0.304 E 371 336 0 0 0 0 [[44, 298]] 1.0 3mvj AGC_PRKACA_HUMAN AGC 5.6e-95 323.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9MA P17612 12 351 351.0 L9M:60351 Type1 Active DFGin 6.702 13.68 BLAminus DFGAsp-rot-in -123.42, 168.26 64.27, 97.86 199.47, -23.49 -112.03, 32.77 297.13, 76.75 -74.15, -5.52 in-in in 9.035 Saltbr-in 2.793 HRD-in -71.88, -60.17 71.32, 14.02 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.62, 165.36 APE9-dihe-na 118.63, -161.51 APE8-dihe-in -116.7, 125.6 APE8-rot-in 304.73 APE67-dihe-in -59.86, -22.26 -32.71, -59.17 APE12-dist-in 8.187 APE11-dist-in 11.209 APE10-dist-in 5.617 APE9-dist-in 3.571 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.223 0.27 A 351 340 0 0 0 0 [[44, 298]] 1.0 3l9m AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9MB P17612 14 351 351.0 L9M:60351 Type1 Active DFGin 6.767 13.738 BLAminus DFGAsp-rot-in -124.39, 166.06 67.02, 98.19 199.53, -25.11 -111.82, 31.79 294.5, 74.52 -67.48, -11.73 in-in in 8.878 Saltbr-in 2.913 HRD-in -76.18, -53.82 65.92, 13.75 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.4, 166.8 APE9-dihe-na 115.45, -164.35 APE8-dihe-in -115.85, 130.97 APE8-rot-in 297.34 APE67-dihe-in -54.51, -26.46 -29.85, -67.98 APE12-dist-in 8.224 APE11-dist-in 11.263 APE10-dist-in 5.658 APE9-dist-in 3.558 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.223 0.27 B 351 338 0 0 0 0 [[44, 298]] 1.0 3l9m AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3L9NA P17612 15 351 351.0 L9N:60351 Type1 Active DFGin 6.423 13.46 BLAminus DFGAsp-rot-in -123.73, 167.95 65.98, 97.53 204.12, -34.05 -115.01, 25.76 300.78, 81.96 -66.98, -19.82 in-in in 9.05 Saltbr-in 2.744 HRD-in -67.38, -52.97 66.43, 17.24 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.06, 165.76 APE9-dihe-na 122.47, -160.51 APE8-dihe-in -116.6, 130.05 APE8-rot-in 304.11 APE67-dihe-in -53.81, -24.08 -30.84, -70.07 APE12-dist-in 8.197 APE11-dist-in 11.394 APE10-dist-in 5.934 APE9-dist-in 3.553 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.217 0.257 A 351 334 0 0 0 0 [[44, 298]] 1.0 3l9n AGC_PRKACA_HUMAN AGC 6e-95 323.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE2A P17612 4 351 351.0 XTI:60501 Type1 Active DFGin 6.142 13.913 BLAminus DFGAsp-rot-in -123.85, 174.03 69.38, 86.41 196.47, -7.09 -105.22, 28.0 281.98, 71.1 -68.62, -14.04 in-in in 8.854 Saltbr-in 2.514 HRD-in -84.66, -51.16 67.93, 20.04 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.46, 164.95 APE9-dihe-na 122.51, -154.32 APE8-dihe-in -114.26, 125.71 APE8-rot-in 301.9 APE67-dihe-in -53.15, -32.01 -48.08, -46.83 APE12-dist-in 8.315 APE11-dist-in 11.573 APE10-dist-in 6.003 APE9-dist-in 3.939 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.34 0.199 0.251 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fe2 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE2B P17612 4 351 351.0 XTI:60501 Type1 Active DFGin 6.227 13.875 BLAminus DFGAsp-rot-in -121.06, -174.83 58.15, 84.69 198.37, -17.08 -101.22, 28.39 282.36, 54.58 -64.33, -23.67 in-in in 8.861 Saltbr-in 2.936 HRD-in -86.41, -49.46 70.11, 7.42 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.54, 160.4 APE9-dihe-na 134.47, -156.72 APE8-dihe-in -118.93, 133.24 APE8-rot-in 292.47 APE67-dihe-in -59.44, -24.84 -53.68, -43.95 APE12-dist-in 8.112 APE11-dist-in 11.51 APE10-dist-in 5.875 APE9-dist-in 3.792 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.34 0.199 0.251 B 405 333 0 0 0 0 [[44, 298]] 1.0 8fe2 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE5A P17612 3 351 351.0 XTT:60501 Type1 Active DFGin 6.6 14.271 BLAminus DFGAsp-rot-in -118.08, 163.41 75.28, 94.71 203.28, -12.14 -111.66, 23.11 283.47, 69.64 -61.06, -23.26 in-in in 8.668 Saltbr-in 2.794 HRD-in -90.95, -53.69 70.13, 22.37 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.31, 157.71 APE9-dihe-na 120.85, -158.74 APE8-dihe-in -109.76, 129.18 APE8-rot-in 307.33 APE67-dihe-in -52.63, -34.99 -47.86, -48.55 APE12-dist-in 8.409 APE11-dist-in 11.54 APE10-dist-in 5.918 APE9-dist-in 3.881 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.51 0.193 0.243 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fe5 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FE5B P17612 4 351 351.0 XTT:60501 Type1 Active DFGin 6.585 14.16 BLAminus DFGAsp-rot-in -125.03, 171.21 68.33, 95.08 204.51, -14.37 -111.16, 25.84 279.92, 72.93 -61.92, -29.97 in-in in 8.694 Saltbr-in 2.655 HRD-in -80.97, -54.69 77.96, 3.27 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.98, 153.65 APE9-dihe-na 132.84, -165.24 APE8-dihe-in -101.75, 136.64 APE8-rot-in 293.15 APE67-dihe-in -60.99, -28.63 -57.01, -42.49 APE12-dist-in 8.343 APE11-dist-in 11.666 APE10-dist-in 6.076 APE9-dist-in 3.865 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.51 0.193 0.243 B 405 336 0 0 0 0 [[44, 298]] 1.0 8fe5 AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FECA P17612 3 351 351.0 XU0:60501 Type1 Active DFGin 5.927 14.461 BLAminus DFGAsp-rot-in -126.38, -179.91 61.84, 90.42 206.73, -8.83 -102.64, 31.23 279.77, 62.7 -61.22, -32.63 in-in in 9.155 Saltbr-in 3.107 HRD-in -85.43, -52.43 73.91, 14.55 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.02, 165.29 APE9-dihe-na 137.47, -140.99 APE8-dihe-in -132.86, 123.05 APE8-rot-in 312.11 APE67-dihe-in -60.14, -32.0 -40.12, -49.13 APE12-dist-in 8.232 APE11-dist-in 11.562 APE10-dist-in 5.955 APE9-dist-in 3.606 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.7 0.214 0.287 A 405 336 0 0 0 0 [[44, 298]] 1.0 8fec AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 8FECB P17612 3 351 351.0 XU0:60501 Type1 Active DFGin 5.975 14.684 BLAminus DFGAsp-rot-in -127.65, 171.34 68.29, 92.72 207.63, -0.98 -102.21, 27.6 281.7, 67.04 -60.34, -31.82 in-in in 8.84 Saltbr-in 2.809 HRD-in -91.52, -53.88 75.61, 9.83 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.24, 178.4 APE9-dihe-na 115.87, -151.85 APE8-dihe-in -128.69, 124.59 APE8-rot-in 281.12 APE67-dihe-in -60.64, -38.43 -38.43, -52.12 APE12-dist-in 8.18 APE11-dist-in 11.378 APE10-dist-in 5.793 APE9-dist-in 3.46 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.214 0.287 B 405 336 0 0 0 0 [[44, 298]] 1.0 8fec AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9NFSA P17612 4 351 351.0 A1BX1:60501 Type1 Active DFGin 6.289 13.616 BLAminus DFGAsp-rot-in -130.7785, 168.6135 68.445, 100.1007 196.8975, -50.7087 -112.4058, 21.0811 282.979, 73.4956 -56.8821, -13.5221 in-in in 8.891 Saltbr-in 3.337 HRD-in -93.0982, -57.1021 79.0878, 19.7924 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.4241, 172.8177 APE9-dihe-na 140.5312, -147.403 APE8-dihe-in -129.0541, 120.1432 APE8-rot-in 289.8434 APE67-dihe-in -57.6402, -31.505 -31.3289, -51.1398 APE12-dist-in 7.963 APE11-dist-in 11.385 APE10-dist-in 5.783 APE9-dist-in 3.659 None TPO198 TPO198 XRAY 2.45 0.282 0.334 A 405 336 0 0 0 0 [[44, 298]] 1.0 9nfs AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9NFSB P17612 4 351 351.0 A1BX1:60501 Type1 Active DFGin 6.023 13.704 BLAminus DFGAsp-rot-in -121.9669, 172.2508 74.2554, 88.121 200.0384, -6.3976 -106.7477, 23.5957 283.7269, 74.2926 -55.4029, -13.3176 in-in in 8.684 Saltbr-in 2.762 HRD-in -107.072, -47.5862 65.993, 15.1387 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.2547, 176.76 APE9-dihe-na 135.9619, -132.0663 APE8-dihe-in -149.8201, 125.8002 APE8-rot-in 307.1569 APE67-dihe-in -54.1174, -49.0959 -37.929, -47.3475 APE12-dist-in 7.889 APE11-dist-in 11.281 APE10-dist-in 5.755 APE9-dist-in 3.467 None TPO198 TPO198 XRAY 2.45 0.282 0.334 B 405 336 0 0 0 0 [[44, 298]] 1.0 9nfs AGC_PRKACA_HUMAN AGC 7.3e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 2GU8A P17612 15 351 351.0 796:61001 Type1 Active DFGin 6.63 14.367 BLAminus DFGAsp-rot-in -112.13, 169.56 64.55, 88.46 197.82, -13.56 -98.67, 24.98 279.28, 59.9 -52.79, -25.6 in-in in 8.969 Saltbr-in 3.03 HRD-in -83.27, -51.67 71.2, 9.61 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.43, 156.76 APE9-dihe-na 146.07, -145.55 APE8-dihe-in -129.46, 134.31 APE8-rot-in 294.43 APE67-dihe-in -57.08, -22.75 -50.07, -49.98 APE12-dist-in 8.04 APE11-dist-in 11.469 APE10-dist-in 5.977 APE9-dist-in 3.507 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.203 0.261 A 337 337 0 0 0 0 [[44, 298]] 1.0 2gu8 AGC_PRKACA_HUMAN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 5N23A P17612 9 351 351.0 35R:60401 Type1 Active DFGin 5.421 13.864 BLAminus DFGAsp-rot-in -109.83, 165.02 72.7, 94.27 204.39, -32.89 -97.78, 24.01 286.85, 71.32 -58.73, -25.18 in-in in 9.5 Saltbr-in 2.927 HRD-in -90.99, -49.74 71.93, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.89, 153.96 APE9-dihe-na 137.51, -163.29 APE8-dihe-in -116.51, 133.79 APE8-rot-in 303.7 APE67-dihe-in -56.98, -24.74 -46.64, -52.33 APE12-dist-in 8.056 APE11-dist-in 11.585 APE10-dist-in 5.945 APE9-dist-in 3.654 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.088 0.192 0.239 A 352 337 0 0 0 0 [[44, 298]] 1.0 5n23 AGC_PRKACA_HUMAN AGC 5.5e-93 316.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 3AMAA P17612 2 351 351.0 SKE:60351 Type1 Active DFGin 5.097 14.026 BLAminus DFGAsp-rot-in -113.5, 162.11 72.12, 95.43 207.93, -32.54 -101.12, 20.61 280.01, 66.12 -51.23, -34.47 in-in in 9.396 Saltbr-in 2.734 HRD-in -88.12, -51.56 68.22, 12.75 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.04, 164.64 APE9-dihe-na 124.94, -160.1 APE8-dihe-in -123.9, 133.09 APE8-rot-in 298.24 APE67-dihe-in -57.85, -22.29 -46.67, -50.91 APE12-dist-in 8.102 APE11-dist-in 11.571 APE10-dist-in 5.902 APE9-dist-in 3.582 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.75 0.198 0.223 A 351 345 0 0 0 0 [[44, 298]] 1.0 3ama AGC_PRKACA_HUMAN AGC 8.1e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6FRXA P17612 13 351 351.0 E3Z:60401 Type1 Active DFGin 5.276 14.242 BLAminus DFGAsp-rot-in -103.8, 165.76 62.73, 100.4 214.25, -78.25 -98.82, 30.34 278.36, 58.69 -63.79, -25.19 in-in in 9.307 Saltbr-in 2.635 HRD-in -83.02, -52.27 73.43, 9.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.05, 168.13 APE9-dihe-na 109.0, -164.56 APE8-dihe-in -112.4, 132.82 APE8-rot-in 302.54 APE67-dihe-in -55.48, -26.17 -48.65, -50.5 APE12-dist-in 8.324 APE11-dist-in 11.711 APE10-dist-in 6.118 APE9-dist-in 3.716 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.88 0.191 0.226 A 351 334 0 0 0 0 [[44, 298]] 1.0 6frx AGC_PRKACA_HUMAN AGC 8.1e-93 316.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACB KAPCB_HUMAN AF-P22694-K1A P22694 36 306 351.0 No_ligand No_ligand Active DFGin 5.735 14.08 BLAminus DFGAsp-rot-in -113.18, -170.6 48.14, 81.8 200.0, 9.2 -87.93, 20.24 276.82, 61.61 -55.85, -32.41 in-in in 8.819 Saltbr-in 2.656 HRD-in -86.21, -47.66 67.2, 5.71 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.21, 165.03 APE9-dihe-na 114.21, -173.02 APE8-dihe-in -104.24, 136.01 APE8-rot-in 300.44 APE67-dihe-in -64.96, -24.87 -48.41, -47.34 APE12-dist-in 8.107 APE11-dist-in 11.463 APE10-dist-in 5.752 APE9-dist-in 3.372 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22694-K1 AGC_PRKACB_HUMAN AGC 6.8e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit beta
AGC PRKACB KAPCB_HUMAN AF-P22694-K3A P22694 36 306 351.0 No_ligand No_ligand Active DFGin 5.906 14.07 BLAminus DFGAsp-rot-in -127.45, -176.84 50.2, 78.93 205.02, -10.14 -82.9, 18.23 290.95, 82.51 -56.89, -30.87 in-in in 8.792 Saltbr-in 2.667 HRD-in -85.56, -50.77 69.25, 7.31 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.25, 161.18 APE9-dihe-na 110.5, 174.06 APE8-dihe-in -79.35, 133.3 APE8-rot-in 289.14 APE67-dihe-in -66.54, -21.67 -47.06, -45.67 APE12-dist-in 8.042 APE11-dist-in 11.143 APE10-dist-in 5.481 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22694-K3 AGC_PRKACB_HUMAN AGC 6.8e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit beta
AGC PRKACG KAPCG_HUMAN AF-P22612-K1A P22612 36 306 351.0 No_ligand No_ligand Active DFGin 6.055 14.157 BLAminus DFGAsp-rot-in -119.69, -175.0 51.86, 76.25 201.65, 14.24 -82.21, 21.45 280.79, 67.93 -55.81, -32.56 in-in in 8.764 Saltbr-in 2.601 HRD-in -83.71, -50.57 67.08, 0.27 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.95, 164.93 APE9-dihe-na 115.6, -172.56 APE8-dihe-in -103.25, 136.92 APE8-rot-in 300.69 APE67-dihe-in -65.17, -25.87 -48.73, -47.57 APE12-dist-in 8.098 APE11-dist-in 11.44 APE10-dist-in 5.756 APE9-dist-in 3.363 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22612-K1 AGC_PRKACG_HUMAN AGC 2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit gamma
AGC PRKACG KAPCG_HUMAN AF-P22612-K3A P22612 36 306 351.0 No_ligand No_ligand Active DFGin 6.169 13.781 BLAminus DFGAsp-rot-in -129.64, -177.35 52.38, 81.61 201.8, -9.83 -84.7, 15.93 297.94, 93.35 -59.08, -32.02 in-in in 8.838 Saltbr-in 2.618 HRD-in -79.24, -49.45 68.23, -1.8 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.43, 159.7 APE9-dihe-na 111.24, 173.65 APE8-dihe-in -73.65, 132.45 APE8-rot-in 288.98 APE67-dihe-in -66.64, -20.45 -47.52, -46.06 APE12-dist-in 8.211 APE11-dist-in 11.264 APE10-dist-in 5.609 APE9-dist-in 3.651 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[44, 298]] 1.0 AF-P22612-K3 AGC_PRKACG_HUMAN AGC 2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit gamma
AGC PRKCA KPCA_HUMAN AF-P17252-K1A P17252 331 605 672.0 No_ligand No_ligand Active DFGin 6.173 13.285 BLAminus DFGAsp-rot-in -134.19, 165.14 67.28, 83.9 200.58, 8.09 -93.09, 16.82 301.84, 90.91 -60.2, -31.47 in-in in 8.702 Saltbr-in 2.65 HRD-in -82.1, -45.11 61.73, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.4, 163.47 APE9-dihe-na 118.86, 165.59 APE8-dihe-in -72.29, 131.08 APE8-rot-in 294.73 APE67-dihe-in -60.18, -26.54 -44.24, -48.61 APE12-dist-in 8.787 APE11-dist-in 12.094 APE10-dist-in 6.517 APE9-dist-in 3.939 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[339, 597]] 1.0 AF-P17252-K1 AGC_PRKCA_HUMAN AGC 1.8e-99 338.0 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN AF-P17252-K3A P17252 331 605 672.0 No_ligand No_ligand Active DFGin 6.225 13.289 BLAminus DFGAsp-rot-in -116.31, -167.6 39.52, 81.02 202.12, 9.08 -87.89, 12.58 300.91, 89.91 -58.46, -29.92 in-in in 8.791 Saltbr-in 2.69 HRD-in -87.62, -44.21 65.44, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 164.78 APE9-dihe-na 116.13, 165.08 APE8-dihe-in -70.89, 133.86 APE8-rot-in 286.57 APE67-dihe-in -59.67, -26.56 -48.45, -48.08 APE12-dist-in 8.697 APE11-dist-in 12.024 APE10-dist-in 6.547 APE9-dist-in 3.501 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[339, 597]] 1.0 AF-P17252-K3 AGC_PRKCA_HUMAN AGC 1.8e-99 338.0 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 4RA4A P17252 332 666 672.0 3KZ:701 Type1 Inactive DFGin 6.918 13.93 BLAminus DFGAsp-rot-out -123.9, -177.92 53.61, 79.44 303.1, 77.6 -93.32, 18.15 296.28, 96.07 -65.95, -42.05 in-in in 8.976 Saltbr-in 2.745 HRD-in -78.16, -48.12 57.66, 11.53 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 158.65 APE9-dihe-na 121.22, 166.98 APE8-dihe-in -70.39, 121.66 APE8-rot-in 310.59 APE67-dihe-in -54.13, -20.67 -38.94, -54.32 APE12-dist-in 8.627 APE11-dist-in 12.129 APE10-dist-in 6.623 APE9-dist-in 4.197 C619S TPO497,TPO638,SEP657 TPO497,TPO638,SEP657 XRAY 2.63 0.19 0.264 A 355 320 0 0 0 0 [[339, 597]] 1.0 4ra4 AGC_PRKCA_HUMAN AGC 3.8e-99 337.0 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4A P17252 331 669 672.0 LW4:901 Type1 Active DFGin 6.623 13.818 BLAminus DFGAsp-rot-in -108.9, -177.56 59.08, 89.37 188.08, -24.45 -106.96, 24.06 294.83, 102.31 -75.53, 23.85 in-in in 8.815 Saltbr-in 2.41 HRD-in -74.65, -45.15 57.81, 14.63 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.54, 165.03 APE9-dihe-na 118.37, 165.26 APE8-dihe-in -73.23, 122.76 APE8-rot-in 296.87 APE67-dihe-in -65.34, -19.42 -43.95, -40.88 APE12-dist-in 9.597 APE11-dist-in 12.404 APE10-dist-in 7.198 APE9-dist-in 4.278 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 A 360 332 0 0 0 0 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4B P17252 332 666 672.0 LW4:901 Type1 Active DFGin 6.418 13.305 BLAminus DFGAsp-rot-in -121.94, -178.66 60.88, 102.14 194.72, -21.46 -120.38, 26.83 301.99, 84.51 -64.84, -10.1 in-in in 8.502 Saltbr-in 2.277 HRD-in -77.23, -55.63 71.28, 15.73 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.82, 155.18 APE9-dihe-na 134.69, -179.0 APE8-dihe-in -84.78, 118.85 APE8-rot-in 310.63 APE67-dihe-in -51.46, -22.6 -31.15, -62.66 APE12-dist-in 9.67 APE11-dist-in 12.179 APE10-dist-in 6.955 APE9-dist-in 3.906 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 B 360 327 1 0 0 1 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 3IW4C P17252 330 670 672.0 LW4:901 Type1 Active DFGin 6.462 13.422 BLAminus DFGAsp-rot-in -141.95, -178.5 58.36, 93.1 173.38, 5.8 -108.43, 30.26 303.23, 90.16 -75.14, 20.66 in-in in 8.688 Saltbr-in 2.568 HRD-in -74.14, -54.37 68.8, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.97, 175.07 APE9-dihe-na 106.85, 167.92 APE8-dihe-in -78.66, 121.4 APE8-rot-in 308.52 APE67-dihe-in -55.88, -21.85 -44.2, -44.83 APE12-dist-in 9.978 APE11-dist-in 12.209 APE10-dist-in 6.918 APE9-dist-in 4.275 T497E TPO638,SEP657 TPO638,SEP657 XRAY 2.8 0.196 0.277 C 360 334 0 0 0 0 [[339, 597]] 1.0 3iw4 AGC_PRKCA_HUMAN AGC 6.7e-99 336.2 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 8U37A P17252 332 666 672.0 V5U:701 Type1 Active DFGin 6.456 13.982 BLAminus DFGAsp-rot-in -124.67, 166.89 71.84, 85.0 194.0, -3.05 -101.61, 23.28 297.19, 92.03 -74.96, -6.46 in-in in 9.247 Saltbr-in 2.92 HRD-in -83.79, -50.86 64.48, 14.73 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.97, 164.54 APE9-dihe-na 123.96, -175.11 APE8-dihe-in -105.91, 130.22 APE8-rot-in 295.66 APE67-dihe-in -58.49, -24.13 -40.33, -55.15 APE12-dist-in 8.912 APE11-dist-in 11.978 APE10-dist-in 6.465 APE9-dist-in 3.97 D463N,V568I,S657E TPO497,TPO638 TPO497,TPO638 XRAY 2.48 0.22 0.258 A 354 320 0 0 0 0 [[339, 597]] 1.0 8u37 AGC_PRKCA_HUMAN AGC 4.8e-98 333.4 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCA KPCA_HUMAN 8UAKA P17252 332 666 672.0 W39:701 Type1 Active DFGin 6.212 13.741 BLAminus DFGAsp-rot-in -125.08, 168.12 72.21, 85.43 197.06, -8.27 -101.49, 23.86 298.05, 92.55 -75.06, -6.75 in-in in 8.95 Saltbr-in 3.138 HRD-in -83.28, -49.78 64.18, 14.31 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.06, 166.71 APE9-dihe-na 125.31, -174.75 APE8-dihe-in -105.85, 130.44 APE8-rot-in 299.2 APE67-dihe-in -58.77, -23.31 -39.4, -55.69 APE12-dist-in 8.681 APE11-dist-in 12.011 APE10-dist-in 6.429 APE9-dist-in 3.766 D463N,V568I,S657E TPO497,TPO638 TPO497,TPO638 XRAY 2.82 0.208 0.243 A 354 319 0 0 0 0 [[339, 597]] 1.0 8uak AGC_PRKCA_HUMAN AGC 4.8e-98 333.4 1 260 260 480 481 482 484 486 368 387 391 460 462 461 463 520 508 503 502 501 500 499 498 497 418 Protein kinase C alpha type
AGC PRKCB KPCB_HUMAN 8SE2A P05771 19 671 671.0 No_ligand No_ligand Inactive DFGin 5.952 13.518 ABAminus DFGAsp-rot-out -120.86, -65.35 -78.48, 119.96 5.87, -8.95 -110.31, 36.28 298.77, 95.28 -76.53, -5.12 in-in in 8.864 Saltbr-in 2.462 HRD-in -90.7, -48.87 74.08, -6.11 in-in-out SNCiio in-out ActLoopNT-in 3.071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -164.48, 160.4 APE9-dihe-na 124.42, 177.98 APE8-dihe-in -99.65, 131.7 APE8-rot-out 40.31 APE67-dihe-in -65.28, -24.14 -48.32, -36.09 APE12-dist-in 8.794 APE11-dist-in 11.988 APE10-dist-in 6.578 APE9-dist-in 3.942 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE3A P05771 30 671 671.0 No_ligand No_ligand Inactive DFGin 6.16 13.709 ABAminus DFGAsp-rot-in -124.07, -33.29 -92.17, 109.74 209.7, -11.84 -116.23, 25.27 297.34, 94.38 -70.45, -20.68 in-in in 8.566 Saltbr-in 2.703 HRD-in -81.86, -43.58 62.11, 4.49 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.91, 179.4 APE9-dihe-na 110.04, -177.12 APE8-dihe-in -93.25, 130.02 APE8-rot-in 297.18 APE67-dihe-in -66.06, -11.73 -57.55, -35.92 APE12-dist-in 8.833 APE11-dist-in 12.028 APE10-dist-in 6.473 APE9-dist-in 3.751 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.199 0.227 A 672 601 0 0 0 0 [[342, 600]] 1.0 8se3 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE4A P05771 19 671 671.0 No_ligand No_ligand Inactive DFGin 6.115 13.438 ABAminus DFGAsp-rot-in -125.45, -34.56 -87.53, 113.0 208.75, -0.9 -119.18, 39.24 297.28, 94.22 -76.92, -28.17 in-in in 8.425 Saltbr-in 2.542 HRD-in -88.36, -49.83 70.03, 0.79 in-in-in SNCiii in-in ActLoopNT-in 3.102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.55, 163.91 APE9-dihe-na 116.91, 175.65 APE8-dihe-in -91.2, 128.82 APE8-rot-in 305.77 APE67-dihe-in -67.42, -22.74 -50.74, -31.22 APE12-dist-in 8.712 APE11-dist-in 11.868 APE10-dist-in 6.374 APE9-dist-in 3.878 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se4 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE4B P05771 30 671 671.0 ADN:701 Type1 Inactive DFGin 5.738 12.971 ABAminus DFGAsp-rot-in -126.66, -34.17 -84.97, 112.43 206.29, -1.41 -117.68, 39.4 296.69, 93.7 -74.7, -30.34 in-in in 8.26 Saltbr-in 2.51 HRD-in -88.0, -50.22 70.29, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.54, 164.05 APE9-dihe-na 118.34, -179.99 APE8-dihe-in -91.65, 129.4 APE8-rot-in 306.62 APE67-dihe-in -69.42, -21.97 -51.1, -33.02 APE12-dist-in 8.632 APE11-dist-in 11.783 APE10-dist-in 6.261 APE9-dist-in 3.776 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se4 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus DFGAsp-rot-in -130.5, -169.38 54.07, 70.37 192.19, 7.48 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus DFGAsp-rot-in -130.75, -169.0 53.85, 70.09 192.17, 8.08 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus DFGAsp-rot-in -122.79, -175.57 50.54, 85.22 197.04, -8.87 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN AF-P05771-K1A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.973 13.023 BLAminus DFGAsp-rot-in -104.35, -161.36 27.53, 84.09 204.83, 11.56 -90.04, 16.15 301.5, 91.82 -59.68, -29.78 in-in in 8.617 Saltbr-in 2.673 HRD-in -85.78, -46.1 64.58, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.82, 162.82 APE9-dihe-na 121.92, 167.13 APE8-dihe-in -72.73, 133.23 APE8-rot-in 298.5 APE67-dihe-in -66.05, -23.0 -49.76, -45.57 APE12-dist-in 8.607 APE11-dist-in 11.905 APE10-dist-in 6.229 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K1 AGC_PRKCB_HUMAN AGC 1.2e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN AF-P05771-K3A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.745 13.195 BLAminus DFGAsp-rot-in -110.85, -172.96 35.96, 94.12 207.07, -18.32 -98.35, 13.42 304.83, 99.89 -60.51, -33.43 in-in in 8.348 Saltbr-in 2.666 HRD-in -84.51, -47.08 65.34, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.41, 161.65 APE9-dihe-na 129.21, 169.52 APE8-dihe-in -83.16, 130.6 APE8-rot-in 297.23 APE67-dihe-in -58.28, -24.56 -44.92, -51.84 APE12-dist-in 8.731 APE11-dist-in 11.81 APE10-dist-in 6.251 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K3 AGC_PRKCB_HUMAN AGC 1.2e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 2I0EA P05771 339 668 671.0 PDS:60901 Type1 Inactive DFGin 6.283 13.949 BLAminus DFGAsp-rot-in -117.76, 167.96 68.91, 88.95 206.25, -27.25 -103.35, 26.8 299.87, 102.06 -70.85, -19.44 in-in in 9.073 Saltbr-in 3.031 HRD-in -81.74, -50.98 74.78, 5.37 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.38, 168.45 APE9-dihe-na 114.4, 163.6 APE8-dihe-in -94.67, 130.59 APE8-rot-out 93.65 APE67-dihe-in -62.49, -23.91 -28.3, -54.88 APE12-dist-in 9.03 APE11-dist-in 11.905 APE10-dist-in 6.388 APE9-dist-in 4.046 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 A 353 327 0 0 0 0 [[342, 600]] 1.0 2i0e AGC_PRKCB_HUMAN AGC 2.8e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 2I0EB P05771 339 668 671.0 PDS:60902 Type1 Active DFGin 6.906 13.595 BLAminus DFGAsp-rot-in -122.54, 163.63 74.87, 90.26 203.8, -3.99 -109.7, 30.33 301.59, 90.18 -89.33, 11.84 in-in in 9.025 Saltbr-in 2.821 HRD-in -82.04, -48.12 70.57, -0.74 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.03, 175.5 APE9-dihe-na 106.77, 155.55 APE8-dihe-in -68.48, 122.99 APE8-rot-in 298.97 APE67-dihe-in -65.65, -22.82 -42.1, -37.43 APE12-dist-in 8.683 APE11-dist-in 12.143 APE10-dist-in 6.729 APE9-dist-in 3.821 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 B 353 300 0 0 0 0 [[342, 600]] 1.0 2i0e AGC_PRKCB_HUMAN AGC 2.8e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 9S9TA P05771 340 667 671.0 LY4:60701 Type1 Inactive DFGin 6.093 13.973 None DFGAsp-rot-in -111.78, -89.62 -67.76, 129.93 189.19, 14.68 -115.94, 12.83 282.89, 115.63 -69.35, -46.77 in-in in 8.522 Saltbr-in 2.723 HRD-in -57.71, -56.78 85.18, -40.4 in-in-in SNCiii in-in ActLoopNT-in 3.456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 131.78 APE9-dihe-na 176.22, -177.75 APE8-dihe-in -90.0, 133.29 APE8-rot-in 321.38 APE67-dihe-in -84.35, -33.13 -46.48, -38.11 APE12-dist-in 8.313 APE11-dist-in 11.686 APE10-dist-in 5.752 APE9-dist-in 4.34 D427N TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.425 0.218 0.29 A 353 315 0 0 0 0 [[342, 600]] 1.0 9s9t AGC_PRKCB_HUMAN AGC 1.3e-97 332.0 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCD KPCD_HUMAN AF-Q05655-K1A Q05655 341 611 676.0 No_ligand No_ligand Active DFGin 5.762 12.98 BLAminus DFGAsp-rot-in -108.87, -152.19 13.42, 84.55 204.41, 7.87 -85.99, 14.4 304.74, 97.93 -60.65, -27.31 in-in in 8.509 Saltbr-in 2.606 HRD-in -83.86, -47.35 64.43, -6.23 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.85, 159.33 APE9-dihe-na 127.37, 165.29 APE8-dihe-in -67.93, 133.61 APE8-rot-in 296.68 APE67-dihe-in -66.15, -22.37 -49.15, -47.86 APE12-dist-in 8.746 APE11-dist-in 11.982 APE10-dist-in 6.38 APE9-dist-in 3.397 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[349, 603]] 1.0 AF-Q05655-K1 AGC_PRKCD_HUMAN AGC 9.9e-93 315.9 1 260 260 490 491 492 494 496 378 397 401 470 472 471 473 530 518 513 512 511 510 509 508 507 428 Protein kinase C delta type
AGC PRKCD KPCD_HUMAN AF-Q05655-K3A Q05655 341 611 676.0 No_ligand No_ligand Active DFGin 5.585 13.044 BLAminus DFGAsp-rot-in -116.86, -177.83 45.18, 84.72 209.8, -15.32 -91.11, 13.43 306.23, 100.59 -59.29, -31.35 in-in in 8.312 Saltbr-in 2.657 HRD-in -81.53, -47.84 67.21, 0.35 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.66, 159.14 APE9-dihe-na 133.74, 168.34 APE8-dihe-in -79.24, 131.18 APE8-rot-in 294.95 APE67-dihe-in -58.09, -22.52 -44.39, -53.02 APE12-dist-in 8.693 APE11-dist-in 11.788 APE10-dist-in 6.219 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[349, 603]] 1.0 AF-Q05655-K3 AGC_PRKCD_HUMAN AGC 9.9e-93 315.9 1 260 260 490 491 492 494 496 378 397 401 470 472 471 473 530 518 513 512 511 510 509 508 507 428 Protein kinase C delta type
AGC PRKCE KPCE_HUMAN AF-Q02156-K1A Q02156 400 676 737.0 No_ligand No_ligand Active DFGin 5.76 12.789 BLAminus DFGAsp-rot-in -109.14, -174.81 42.5, 79.36 205.62, 6.1 -85.06, 16.43 303.93, 96.39 -63.79, -28.29 in-in in 8.728 Saltbr-in 2.692 HRD-in -84.34, -46.8 62.89, 1.98 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.52, 164.55 APE9-dihe-na 130.34, 177.4 APE8-dihe-in -87.15, 127.62 APE8-rot-in 296.09 APE67-dihe-in -64.76, -22.51 -47.37, -45.68 APE12-dist-in 8.909 APE11-dist-in 11.876 APE10-dist-in 6.222 APE9-dist-in 3.449 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[408, 668]] 1.0 AF-Q02156-K1 AGC_PRKCE_HUMAN AGC 7.3e-100 339.3 1 260 260 549 550 551 553 555 437 456 460 529 531 530 532 589 577 572 571 570 569 568 567 566 487 Protein kinase C epsilon type
AGC PRKCE KPCE_HUMAN AF-Q02156-K3A Q02156 400 676 737.0 No_ligand No_ligand Active DFGin 5.779 12.705 BLAminus DFGAsp-rot-in -119.92, 177.83 55.03, 75.07 204.48, 0.28 -88.27, 15.42 307.81, 102.74 -68.02, -28.02 in-in in 8.299 Saltbr-in 2.731 HRD-in -85.36, -48.33 64.74, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.67, 163.72 APE9-dihe-na 137.29, 172.07 APE8-dihe-in -87.55, 129.61 APE8-rot-in 294.41 APE67-dihe-in -58.17, -22.63 -44.36, -52.53 APE12-dist-in 8.898 APE11-dist-in 11.747 APE10-dist-in 6.206 APE9-dist-in 3.412 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[408, 668]] 1.0 AF-Q02156-K3 AGC_PRKCE_HUMAN AGC 7.3e-100 339.3 1 260 260 549 550 551 553 555 437 456 460 529 531 530 532 589 577 572 571 570 569 568 567 566 487 Protein kinase C epsilon type
AGC PRKCG KPCG_HUMAN AF-P05129-K1A P05129 343 622 697.0 No_ligand No_ligand Active DFGin 6.105 12.952 BLAminus DFGAsp-rot-in -111.37, -152.57 16.87, 87.61 202.66, 9.05 -91.31, 13.91 302.66, 90.5 -59.22, -30.54 in-in in 8.569 Saltbr-in 2.688 HRD-in -83.15, -45.84 63.41, -0.56 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.46, 165.12 APE9-dihe-na 116.59, 162.28 APE8-dihe-in -64.96, 134.05 APE8-rot-in 287.01 APE67-dihe-in -65.51, -23.33 -48.83, -46.67 APE12-dist-in 8.64 APE11-dist-in 11.898 APE10-dist-in 6.241 APE9-dist-in 3.459 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[351, 614]] 1.0 AF-P05129-K1 AGC_PRKCG_HUMAN AGC 2.4e-93 317.9 1 260 260 497 498 499 501 503 380 399 403 477 479 478 480 537 525 520 519 518 517 516 515 514 435 Protein kinase C gamma type
AGC PRKCG KPCG_HUMAN AF-P05129-K3A P05129 343 622 697.0 No_ligand No_ligand Active DFGin 6.162 13.252 BLAminus DFGAsp-rot-in -108.58, -167.98 34.6, 86.68 203.33, -1.32 -90.71, 13.96 301.23, 91.08 -61.22, -32.03 in-in in 8.68 Saltbr-in 2.626 HRD-in -84.75, -46.91 68.8, 2.98 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.3, 168.77 APE9-dihe-na 113.09, 167.53 APE8-dihe-in -80.1, 133.75 APE8-rot-in 300.08 APE67-dihe-in -59.0, -24.44 -48.22, -50.17 APE12-dist-in 8.519 APE11-dist-in 11.869 APE10-dist-in 6.272 APE9-dist-in 3.378 None None None AF2 -1.0 1.0 1.0 A 280 280 0 0 0 0 [[351, 614]] 1.0 AF-P05129-K3 AGC_PRKCG_HUMAN AGC 2.4e-93 317.9 1 260 260 497 498 499 501 503 380 399 403 477 479 478 480 537 525 520 519 518 517 516 515 514 435 Protein kinase C gamma type
AGC PRKCH KPCL_HUMAN AF-P24723-K1A P24723 347 622 683.0 No_ligand No_ligand Active DFGin 5.749 12.772 BLAminus DFGAsp-rot-in -106.1, -173.16 38.28, 91.09 206.39, -2.31 -97.14, 16.07 304.8, 94.12 -62.68, -25.89 in-in in 8.525 Saltbr-in 2.617 HRD-in -85.22, -48.7 63.75, -0.17 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.59, 159.8 APE9-dihe-na 134.84, 173.72 APE8-dihe-in -79.82, 127.49 APE8-rot-in 296.6 APE67-dihe-in -67.71, -17.85 -43.24, -50.27 APE12-dist-in 8.71 APE11-dist-in 11.608 APE10-dist-in 5.964 APE9-dist-in 3.432 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[355, 614]] 1.0 AF-P24723-K1 AGC_PRKCH_HUMAN AGC 7.1e-98 332.8 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN AF-P24723-K3A P24723 347 622 683.0 No_ligand No_ligand Active DFGin 5.486 12.838 BLAminus DFGAsp-rot-in -113.3, -173.79 33.92, 96.43 208.65, -6.72 -97.69, 15.91 306.27, 99.4 -63.08, -28.8 in-in in 8.388 Saltbr-in 2.625 HRD-in -87.28, -49.72 68.32, -5.12 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.76, 163.25 APE9-dihe-na 130.19, 175.68 APE8-dihe-in -87.39, 133.47 APE8-rot-in 293.76 APE67-dihe-in -64.49, -20.83 -48.29, -47.55 APE12-dist-in 8.681 APE11-dist-in 11.638 APE10-dist-in 6.033 APE9-dist-in 3.433 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[355, 614]] 1.0 AF-P24723-K3 AGC_PRKCH_HUMAN AGC 7.1e-98 332.8 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.04 12.861 BLAminus DFGAsp-rot-in -134.17, 160.39 76.6, 103.68 196.33, -14.99 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.529 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.666 APE11-dist-in 11.701 APE10-dist-in 6.365 APE9-dist-in 3.566 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353 328 0 0 0 0 [[355, 614]] 1.0 8fp1 AGC_PRKCH_HUMAN AGC 1.7e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN 8FP3A P24723 349 679 683.0 Y3I:9000 Type1 Active DFGin 6.22 13.226 BLAminus DFGAsp-rot-in -127.87, 165.42 68.91, 93.86 200.87, -5.67 -107.42, 16.9 300.66, 99.02 -64.47, -31.74 in-in in 8.835 Saltbr-in 2.953 HRD-in -62.84, -58.95 67.06, -3.18 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.98, 170.15 APE9-dihe-na 118.17, 177.41 APE8-dihe-in -88.28, 125.69 APE8-rot-in 312.19 APE67-dihe-in -66.78, -22.74 -44.71, -43.76 APE12-dist-in 8.702 APE11-dist-in 11.681 APE10-dist-in 6.178 APE9-dist-in 3.426 S675E TPO513,TPO656 TPO513,TPO656 XRAY 2.3 0.198 0.256 A 353 331 0 0 0 0 [[355, 614]] 1.0 8fp3 AGC_PRKCH_HUMAN AGC 1.7e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCH KPCL_HUMAN 3TXOA P24723 353 679 683.0 07U:1 Type1 Inactive DFGin 6.194 12.867 BLAminus DFGAsp-rot-in -131.98, 154.73 77.42, 93.31 193.36, -9.16 -108.7, 22.52 305.55, 91.59 -71.89, -20.94 in-in in 8.675 Saltbr-in 2.739 HRD-in -77.21, -43.2 71.88, -16.47 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -168.17 APE8-dihe-in -81.7, 128.35 APE8-rot-in 299.86 APE67-dihe-in -64.49, -27.49 -50.95, -35.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 25.627 S675E TPO656 TPO656 XRAY 2.05 0.212 0.241 A 353 318 9 0 0 9 [[355, 614]] 1.0 3txo AGC_PRKCH_HUMAN AGC 1.7e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
AGC PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.372 12.488 ABAminus DFGAsp-rot-in -142.84, 3.21 -114.63, 115.49 177.84, 51.63 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.816 Saltbr-out 4.241 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.863 APE11-dist-in 11.282 APE10-dist-in 5.856 APE9-dist-in 3.498 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338 338 0 0 0 0 [[254, 522]] 1.0 8r3y AGC_PRKCI_HUMAN AGC 1.1e-95 325.7 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 8R3XA P41743 249 588 596.0 No_ligand No_ligand Inactive DFGin 5.789 12.657 ABAminus DFGAsp-rot-out -120.55, -62.73 -83.47, 105.52 275.3, 20.19 -97.36, 7.54 309.71, 135.25 -66.01, -26.35 in-out in 8.675 Saltbr-out 4.098 HRD-in -74.93, -54.1 72.92, 4.26 out-in-in SNCoii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.73, 162.47 APE9-dihe-na 134.4, -143.72 APE8-dihe-in -134.56, 123.62 APE8-rot-in 297.56 APE67-dihe-in -56.39, -41.71 -45.2, -41.49 APE12-dist-in 8.806 APE11-dist-in 11.842 APE10-dist-in 6.115 APE9-dist-in 3.392 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 A 356 340 0 0 0 0 [[254, 522]] 1.0 8r3x AGC_PRKCI_HUMAN AGC 1.3e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 8R3XB P41743 249 587 596.0 No_ligand No_ligand Inactive DFGin 5.412 12.675 ABAminus DFGAsp-rot-in -124.75, -60.53 -82.56, 104.3 172.3, 3.0 -97.59, 10.1 309.28, 136.28 -63.5, -26.7 in-in in 9.32 Saltbr-in 2.579 HRD-in -74.34, -54.48 73.27, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.88, 161.36 APE9-dihe-na 132.08, -145.04 APE8-dihe-in -133.89, 124.43 APE8-rot-in 298.47 APE67-dihe-in -59.19, -41.22 -42.94, -43.02 APE12-dist-in 8.778 APE11-dist-in 11.842 APE10-dist-in 6.106 APE9-dist-in 3.399 None TPO412,TPO564 TPO412,TPO564 XRAY 2.591 0.234 0.269 B 356 339 0 0 0 0 [[254, 522]] 1.0 8r3x AGC_PRKCI_HUMAN AGC 1.3e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZA P41743 254 587 596.0 AFU:601 Type1 Inactive DFGin 5.524 12.274 ABAminus DFGAsp-rot-in -101.22, -50.19 -115.29, 89.28 160.9, 29.05 -72.99, 31.3 307.01, 139.52 -87.24, -45.36 in-none in 8.839 Saltbr-none 999.0 HRD-in -53.35, -56.43 62.18, -10.31 none-in-in SNCnii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.77, 144.04 APE9-dihe-na -176.45, 171.24 APE8-dihe-in -98.87, 140.23 APE8-rot-in 302.07 APE67-dihe-in -72.12, -45.53 -55.29, -41.31 APE12-dist-in 8.351 APE11-dist-in 11.182 APE10-dist-in 5.48 APE9-dist-in 4.113 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 A 345 320 14 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.174 12.378 BLAminus DFGAsp-rot-in -132.69, 170.49 67.34, 88.86 204.44, -20.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.357 Saltbr-out 3.882 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.769 APE11-dist-in 11.767 APE10-dist-in 6.259 APE9-dist-in 3.666 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345 325 15 0 0 0 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.257 12.324 BLAminus DFGAsp-rot-in -133.61, 172.63 64.84, 89.8 196.94, -9.46 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.192 Saltbr-out 3.977 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.76 APE11-dist-in 11.726 APE10-dist-in 6.539 APE9-dist-in 3.77 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345 326 14 0 0 3 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.403 11.863 BLAminus DFGAsp-rot-in -129.58, 178.7 63.64, 84.98 184.94, 11.75 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.178 Saltbr-in 3.031 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.986 APE10-dist-in 5.421 APE9-dist-in 3.56 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349 326 15 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.31 11.876 BLAminus DFGAsp-rot-in -129.18, 178.42 63.46, 84.62 184.86, 11.73 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.72 Saltbr-in 2.545 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.329 APE11-dist-in 11.256 APE10-dist-in 5.693 APE9-dist-in 3.742 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349 320 20 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI9A P41743 248 589 596.0 ACP:60601 ATPlike Active DFGin 5.635 12.633 BLAminus DFGAsp-rot-in -139.17, 172.4 72.31, 78.11 201.72, -12.7 -98.86, 1.23 304.03, 143.26 -64.9, -22.84 in-in in 8.361 Saltbr-in 2.614 HRD-in -73.79, -55.22 70.11, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.64, 169.55 APE9-dihe-na 127.72, -178.47 APE8-dihe-in -93.25, 127.56 APE8-rot-in 298.81 APE67-dihe-in -60.64, -20.02 -47.28, -45.36 APE12-dist-in 8.812 APE11-dist-in 11.949 APE10-dist-in 6.432 APE9-dist-in 3.836 None TPO412,TPO564 TPO412,TPO564 XRAY 1.79 0.19 0.231 A 350 330 12 0 0 0 [[254, 522]] 1.0 5li9 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.079 11.961 BLAminus DFGAsp-rot-in -129.24, 176.98 73.22, 90.17 187.2, 4.73 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.816 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.752 APE11-dist-in 11.822 APE10-dist-in 6.31 APE9-dist-in 3.517 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354 332 10 0 0 0 [[254, 522]] 1.0 5li1 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2 12.865 BLAminus DFGAsp-rot-in -142.99, -166.55 58.77, 70.37 191.3, 11.27 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.166 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.603 APE11-dist-in 12.253 APE10-dist-in 6.595 APE9-dist-in 3.928 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596 322 9 0 0 0 [[254, 522]] 1.0 9ejm AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN AF-P41743-K1A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.447 12.405 BLAminus DFGAsp-rot-in -131.03, -165.82 44.28, 65.55 207.94, 24.01 -76.76, 9.18 306.63, 118.08 -56.74, -36.72 in-in in 8.45 Saltbr-in 2.623 HRD-in -77.0, -41.44 60.49, -7.42 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.06, 173.77 APE9-dihe-na 111.64, 163.54 APE8-dihe-in -68.62, 127.52 APE8-rot-in 295.24 APE67-dihe-in -71.1, -16.65 -47.7, -40.44 APE12-dist-in 8.652 APE11-dist-in 11.892 APE10-dist-in 6.185 APE9-dist-in 3.578 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[254, 522]] 1.0 AF-P41743-K1 AGC_PRKCI_HUMAN AGC 5.7e-96 326.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN AF-P41743-K3A P41743 246 530 596.0 No_ligand No_ligand Active DFGin 5.067 12.263 BLAminus DFGAsp-rot-in -132.42, 177.52 58.72, 87.78 207.01, 0.36 -95.71, 10.36 309.96, 125.27 -59.78, -23.56 in-in in 8.434 Saltbr-in 2.609 HRD-in -81.78, -44.52 65.41, -3.76 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.16, 168.09 APE9-dihe-na 113.77, 166.26 APE8-dihe-in -77.9, 128.97 APE8-rot-in 291.1 APE67-dihe-in -65.12, -20.54 -47.59, -43.64 APE12-dist-in 8.77 APE11-dist-in 11.646 APE10-dist-in 6.116 APE9-dist-in 3.269 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[254, 522]] 1.0 AF-P41743-K3 AGC_PRKCI_HUMAN AGC 5.7e-96 326.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8XA P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.479 12.306 BLAminus DFGAsp-rot-in -133.56, 171.16 66.18, 84.73 191.3, -29.14 -94.69, 12.13 305.3, 131.59 -63.13, -17.58 in-in in 8.784 Saltbr-in 2.575 HRD-in -71.12, -56.95 73.87, -4.8 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -172.63, 123.28 APE9-dihe-na 133.81, -165.17 APE8-dihe-in -100.11, 125.82 APE8-rot-in 300.75 APE67-dihe-in -55.67, -25.11 -46.23, -50.55 APE12-dist-in 8.534 APE11-dist-in 11.685 APE10-dist-in 6.739 APE9-dist-in 3.798 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 A 345 333 7 0 0 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8XB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 5.196 12.363 BLAminus DFGAsp-rot-in -134.81, 172.86 61.29, 86.65 182.43, -6.13 -89.58, 25.14 305.87, 129.78 -77.51, -26.88 in-in in 8.854 Saltbr-in 3.141 HRD-in -71.84, -53.34 75.49, -1.11 in-in-in SNCiii in-in ActLoopNT-in 2.755 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.8, 129.32 APE9-dihe-na 125.34, -174.85 APE8-dihe-in -94.58, 120.99 APE8-rot-in 296.51 APE67-dihe-in -60.75, -26.64 -37.16, -45.74 APE12-dist-in 8.85 APE11-dist-in 11.874 APE10-dist-in 6.855 APE9-dist-in 3.878 None TPO412,TPO564 TPO412,TPO564 XRAY 2.0 0.225 0.271 B 345 327 13 0 0 0 [[254, 522]] 1.0 3a8x AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJKB P41743 249 588 596.0 No_ligand No_ligand Active DFGin 6.322 12.883 BLAminus DFGAsp-rot-in -140.76, 171.15 65.08, 85.19 184.74, 1.57 -104.47, 31.46 313.7, 135.04 -76.2, -15.07 in-in in 9.004 Saltbr-in 3.533 HRD-in -63.1, -53.44 69.1, -3.37 in-in-in SNCiii in-in ActLoopNT-in 3.455 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 154.63 APE9-dihe-na 128.06, 155.44 APE8-dihe-in -56.67, 121.19 APE8-rot-in 310.7 APE67-dihe-in -58.25, -24.63 -54.37, -39.36 APE12-dist-in 9.377 APE11-dist-in 12.385 APE10-dist-in 6.726 APE9-dist-in 4.126 None TPO412,TPO564 TPO412,TPO564 EM 3.08 999.0 999.0 B 596 320 9 0 0 0 [[254, 522]] 1.0 9ejk AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJLB P41743 25 588 596.0 No_ligand No_ligand Active DFGin 5.78 13.01 BLAminus DFGAsp-rot-in -138.05, 176.56 63.52, 82.24 184.24, 1.31 -100.53, 29.28 318.31, 120.09 -73.2, -15.29 in-in in 8.71 Saltbr-in 3.107 HRD-in -63.42, -52.9 69.14, -4.84 in-in-in SNCiii in-in ActLoopNT-in 3.39 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.27, 154.98 APE9-dihe-na 129.08, 155.07 APE8-dihe-in -56.55, 121.43 APE8-rot-in 311.13 APE67-dihe-in -59.47, -23.97 -53.96, -40.11 APE12-dist-in 9.615 APE11-dist-in 12.402 APE10-dist-in 6.733 APE9-dist-in 4.127 None TPO412,TPO564 TPO412,TPO564 EM 3.48 999.0 999.0 B 596 506 0 0 0 0 [[254, 522]] 1.0 9ejl AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZC P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.35 12.565 BLAminus DFGAsp-rot-in -139.32, -164.03 47.55, 59.28 216.71, 4.72 -80.83, 61.9 308.74, 123.06 -106.89, -43.16 in-none in 9.109 Saltbr-none 999.0 HRD-in -73.5, -52.72 54.13, -0.86 none-in-in SNCnii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -173.36, 149.93 APE9-dihe-na 148.31, -160.27 APE8-dihe-in -114.43, 136.89 APE8-rot-in 309.46 APE67-dihe-in -57.11, -55.6 -58.53, -45.22 APE12-dist-in 9.055 APE11-dist-in 10.952 APE10-dist-in 5.478 APE9-dist-in 4.001 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 C 345 317 15 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZE P41743 255 587 596.0 AFU:601 Type1 None DFGin 6.957 12.846 BLAminus DFGAsp-rot-in -133.5, 178.86 66.81, 59.27 191.09, -13.89 -86.16, 63.15 305.7, 112.11 -113.68, -42.34 in-none in 8.722 Saltbr-none 999.0 HRD-in -57.41, -56.51 65.78, 5.3 none-in-in SNCnii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.18, 118.96 APE9-dihe-na -158.88, 157.43 APE8-dihe-in -112.73, 131.93 APE8-rot-in 318.3 APE67-dihe-in -62.09, -40.72 -61.87, -47.3 APE12-dist-in 9.305 APE11-dist-in 10.843 APE10-dist-in 5.436 APE9-dist-in 4.947 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 E 345 316 16 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZG P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.208 12.257 BLAminus DFGAsp-rot-in -148.76, -174.16 47.03, 68.4 201.65, 19.07 -82.07, 61.51 312.36, 107.63 -107.63, -40.38 in-none in 8.922 Saltbr-none 999.0 HRD-in -68.38, -50.26 58.54, -1.28 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 131.51 APE9-dihe-na -176.4, 176.09 APE8-dihe-in -116.21, 141.66 APE8-rot-in 312.23 APE67-dihe-in -65.11, -53.96 -57.73, -45.37 APE12-dist-in 8.827 APE11-dist-in 10.598 APE10-dist-in 4.936 APE9-dist-in 4.581 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 G 345 315 14 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8A P41743 248 590 596.0 C58:61582 Type1 Active DFGin 5.556 12.002 BLAminus DFGAsp-rot-in -130.37, -178.04 51.18, 83.54 180.62, 17.37 -87.27, 17.91 304.14, 111.3 -61.33, -13.38 in-in in 9.325 Saltbr-in 3.341 HRD-in -65.53, -55.38 66.64, 24.69 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 178.63 APE9-dihe-na 118.81, -170.03 APE8-dihe-in -107.2, 114.73 APE8-rot-in 305.39 APE67-dihe-in -50.56, -25.42 -31.13, -57.8 APE12-dist-in 8.723 APE11-dist-in 11.789 APE10-dist-in 6.195 APE9-dist-in 3.857 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 A 349 320 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8B P41743 248 589 596.0 C58:61581 Type1 Active DFGin 5.505 12.036 BLAminus DFGAsp-rot-in -129.65, -179.53 51.29, 82.99 180.55, 17.08 -86.76, 19.25 305.39, 112.3 -61.07, -14.24 in-in in 9.33 Saltbr-in 3.256 HRD-in -64.76, -55.3 66.61, 24.25 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, 178.62 APE9-dihe-na 117.31, -170.26 APE8-dihe-in -107.45, 114.14 APE8-rot-in 306.11 APE67-dihe-in -50.63, -24.48 -30.49, -58.16 APE12-dist-in 8.839 APE11-dist-in 11.985 APE10-dist-in 6.37 APE9-dist-in 3.864 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 B 349 319 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3ZH8C P41743 248 588 596.0 C58:61580 Type1 Active DFGin 5.796 12.073 BLAminus DFGAsp-rot-in -128.69, -178.25 53.53, 81.54 180.64, 17.88 -88.45, 18.44 303.41, 111.5 -61.77, -13.25 in-in in 9.367 Saltbr-in 3.275 HRD-in -64.18, -55.09 66.76, 24.05 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.52, 178.89 APE9-dihe-na 116.26, -170.7 APE8-dihe-in -106.06, 114.81 APE8-rot-in 304.72 APE67-dihe-in -49.82, -25.77 -29.67, -57.17 APE12-dist-in 8.928 APE11-dist-in 11.778 APE10-dist-in 6.17 APE9-dist-in 3.786 C595S TPO412,TPO564 TPO412,TPO564 XRAY 2.739 0.213 0.257 C 349 314 8 0 0 0 [[254, 522]] 1.0 3zh8 AGC_PRKCI_HUMAN AGC 1.2e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 1ZRZA P41743 249 588 596.0 BI1:61000 Type1 Active DFGin 5.407 12.571 BLAminus DFGAsp-rot-in -130.8, 174.67 64.45, 118.73 183.45, -58.03 -128.08, 29.21 300.88, 154.48 -95.06, 36.97 in-in in 8.489 Saltbr-in 2.773 HRD-in -48.25, -53.67 63.34, -15.36 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.12, -165.87 APE9-dihe-na 92.97, 155.51 APE8-dihe-in -67.22, 110.52 APE8-rot-in 321.88 APE67-dihe-in -51.87, -24.47 -26.14, -57.0 APE12-dist-in 8.399 APE11-dist-in 11.824 APE10-dist-in 6.456 APE9-dist-in 3.789 None TPO412,TPO564 TPO412,TPO564 XRAY 3.0 0.249 0.333 A 364 312 9 0 0 0 [[254, 522]] 1.0 1zrz AGC_PRKCI_HUMAN AGC 2.5e-95 324.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCQ KPCT_HUMAN AF-Q04759-K1A Q04759 372 642 706.0 No_ligand No_ligand Active DFGin 5.888 13.092 BLAminus DFGAsp-rot-in -111.47, -161.58 28.49, 81.48 202.79, 9.55 -87.29, 15.51 303.95, 98.21 -58.98, -28.73 in-in in 8.489 Saltbr-in 2.611 HRD-in -79.51, -46.72 64.6, -6.08 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.83, 164.71 APE9-dihe-na 120.22, 165.8 APE8-dihe-in -69.46, 133.57 APE8-rot-in 297.66 APE67-dihe-in -68.66, -21.56 -49.68, -45.16 APE12-dist-in 8.698 APE11-dist-in 12.045 APE10-dist-in 6.447 APE9-dist-in 3.501 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[380, 634]] 1.0 AF-Q04759-K1 AGC_PRKCQ_HUMAN AGC 5.2e-96 326.7 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN AF-Q04759-K3A Q04759 372 642 706.0 No_ligand No_ligand Active DFGin 5.719 13.112 BLAminus DFGAsp-rot-in -115.41, 178.48 45.7, 90.34 205.98, -12.57 -95.22, 12.74 305.99, 102.65 -59.82, -31.49 in-in in 8.395 Saltbr-in 2.63 HRD-in -80.31, -47.4 66.14, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.38, 163.76 APE9-dihe-na 124.04, 165.42 APE8-dihe-in -77.47, 131.1 APE8-rot-in 294.41 APE67-dihe-in -61.12, -22.91 -45.2, -50.91 APE12-dist-in 8.834 APE11-dist-in 11.702 APE10-dist-in 6.141 APE9-dist-in 3.332 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[380, 634]] 1.0 AF-Q04759-K3 AGC_PRKCQ_HUMAN AGC 5.2e-96 326.7 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 4Q9ZA Q04759 375 706 706.0 PZW:60801 Type1 Inactive DFGin 6.498 13.983 BLAminus DFGAsp-rot-out -129.62, 170.17 59.89, 78.05 295.01, 61.99 -94.48, 11.49 301.06, 109.09 -65.66, -19.81 in-in in 8.866 Saltbr-in 2.588 HRD-in -84.02, -47.96 72.84, -13.44 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.72, 164.65 APE9-dihe-na 122.97, 176.49 APE8-dihe-in -90.21, 130.45 APE8-rot-in 303.85 APE67-dihe-in -60.12, -27.82 -40.48, -49.54 APE12-dist-in 9.873 APE11-dist-in 11.953 APE10-dist-in 6.367 APE9-dist-in 3.63 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.6 0.22 0.256 A 334 332 0 0 0 0 [[380, 634]] 1.0 4q9z AGC_PRKCQ_HUMAN AGC 5.5e-96 326.6 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 4Q9ZB Q04759 374 704 706.0 PZW:60801 Type1 Inactive DFGin 6.46 14.069 BLAminus DFGAsp-rot-out -122.43, 171.24 60.71, 80.12 307.43, -25.28 -96.99, 17.44 300.93, 103.53 -66.22, -22.55 in-in in 9.042 Saltbr-in 3.222 HRD-in -78.02, -50.1 71.67, -5.88 in-in-in SNCiii in-in ActLoopNT-in 3.045 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.73, 161.59 APE9-dihe-na 120.2, 169.91 APE8-dihe-in -85.09, 127.51 APE8-rot-in 308.63 APE67-dihe-in -57.39, -28.45 -39.09, -50.47 APE12-dist-in 9.549 APE11-dist-in 11.819 APE10-dist-in 6.295 APE9-dist-in 3.551 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.6 0.22 0.256 B 334 309 0 0 0 0 [[380, 634]] 1.0 4q9z AGC_PRKCQ_HUMAN AGC 5.5e-96 326.6 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 4RA5A Q04759 374 706 706.0 3L0:60801 Type1 Inactive DFGin 6.502 13.706 BLAminus DFGAsp-rot-out -130.8, 165.47 60.37, 80.63 276.74, 10.6 -96.28, 13.82 305.06, 108.57 -65.07, -21.73 in-in in 8.69 Saltbr-in 2.706 HRD-in -81.4, -52.17 72.03, -7.02 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.29, 168.72 APE9-dihe-na 122.43, 171.49 APE8-dihe-in -88.88, 125.08 APE8-rot-in 316.66 APE67-dihe-in -56.04, -31.31 -40.84, -48.14 APE12-dist-in 8.865 APE11-dist-in 12.086 APE10-dist-in 6.506 APE9-dist-in 3.478 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.61 0.23 0.277 A 334 333 0 0 0 0 [[380, 634]] 1.0 4ra5 AGC_PRKCQ_HUMAN AGC 5.5e-96 326.6 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 4RA5B Q04759 375 701 706.0 3L0:60801 Type1 Inactive DFGin 6.5 13.958 BLAminus DFGAsp-rot-out -124.58, 172.11 61.76, 74.37 274.89, 18.79 -91.68, 16.04 298.23, 101.99 -61.29, -29.96 in-in in 8.813 Saltbr-in 2.768 HRD-in -76.54, -51.94 71.71, -2.05 in-in-in SNCiii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.62, 162.67 APE9-dihe-na 133.57, -170.02 APE8-dihe-in -109.6, 121.98 APE8-rot-in 311.54 APE67-dihe-in -60.14, -31.4 -32.49, -52.6 APE12-dist-in 8.733 APE11-dist-in 12.019 APE10-dist-in 6.492 APE9-dist-in 3.575 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.61 0.23 0.277 B 334 312 0 0 0 0 [[380, 634]] 1.0 4ra5 AGC_PRKCQ_HUMAN AGC 5.5e-96 326.6 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 2JEDA Q04759 375 700 706.0 LG8:61701 Type1 Active DFGin 6.614 13.667 BLAminus DFGAsp-rot-in -113.39, 165.43 67.55, 92.49 205.96, -25.95 -102.81, 25.08 299.09, 96.04 -77.76, -4.74 in-in in 8.698 Saltbr-in 3.201 HRD-in -82.61, -46.83 69.15, -8.62 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.64, 141.45 APE9-dihe-na 144.48, -176.42 APE8-dihe-in -112.96, 132.15 APE8-rot-in 286.91 APE67-dihe-in -65.19, -26.4 -40.31, -53.61 APE12-dist-in 8.797 APE11-dist-in 11.75 APE10-dist-in 5.962 APE9-dist-in 3.883 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.32 0.188 0.221 A 352 326 0 0 0 0 [[380, 634]] 1.0 2jed AGC_PRKCQ_HUMAN AGC 6.5e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 2JEDB Q04759 375 706 706.0 LG8:61712 Type1 Active DFGin 6.477 13.775 BLAminus DFGAsp-rot-in -116.9, 164.62 69.71, 89.68 205.74, -25.34 -101.74, 24.61 303.13, 88.06 -65.56, -17.66 in-in in 8.91 Saltbr-in 3.02 HRD-in -77.46, -49.1 72.97, -12.75 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.05, 132.52 APE9-dihe-na 123.41, 168.41 APE8-dihe-in -74.67, 129.81 APE8-rot-in 290.27 APE67-dihe-in -53.63, -32.33 -43.76, -48.79 APE12-dist-in 8.773 APE11-dist-in 11.68 APE10-dist-in 6.647 APE9-dist-in 4.1 I381E,T538E SEP676,SEP695 SEP676,SEP695 XRAY 2.32 0.188 0.221 B 352 317 0 0 0 0 [[380, 634]] 1.0 2jed AGC_PRKCQ_HUMAN AGC 6.5e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 5F9EA Q04759 374 706 706.0 5VS:61001 Type1 Active DFGin 6.476 13.852 BLAminus DFGAsp-rot-in -124.47, 161.09 72.18, 90.67 193.54, -5.54 -101.4, 15.51 297.35, 95.13 -63.75, -26.0 in-in in 9.058 Saltbr-in 2.717 HRD-in -81.15, -47.98 73.24, -5.11 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.97, 169.63 APE9-dihe-na 131.49, -173.01 APE8-dihe-in -109.76, 129.84 APE8-rot-in 295.69 APE67-dihe-in -61.77, -26.26 -46.68, -44.42 APE12-dist-in 8.954 APE11-dist-in 12.017 APE10-dist-in 6.561 APE9-dist-in 3.659 None SEP676,SEP695 SEP676,SEP695 XRAY 2.0 0.199 0.233 A 353 333 0 0 0 0 [[380, 634]] 1.0 5f9e AGC_PRKCQ_HUMAN AGC 6.6e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 5F9EB Q04759 375 700 706.0 5VS:61001 Type1 Active DFGin 6.583 13.885 BLAminus DFGAsp-rot-in -118.45, 165.26 62.54, 88.94 193.49, -6.25 -98.52, 15.46 302.93, 89.41 -59.36, -22.06 in-in in 9.267 Saltbr-in 2.59 HRD-in -84.26, -45.13 71.76, -7.56 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.19, 135.47 APE9-dihe-na 127.82, -166.17 APE8-dihe-in -112.12, 133.27 APE8-rot-in 297.56 APE67-dihe-in -57.44, -27.74 -44.31, -54.84 APE12-dist-in 8.768 APE11-dist-in 12.046 APE10-dist-in 7.323 APE9-dist-in 3.578 None SEP676,SEP695 SEP676,SEP695 XRAY 2.0 0.199 0.233 B 353 294 0 0 0 0 [[380, 634]] 1.0 5f9e AGC_PRKCQ_HUMAN AGC 6.6e-96 326.4 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCQ KPCT_HUMAN 1XJDA Q04759 377 696 706.0 STU:200 Type1 Active DFGin 5.828 13.193 BLAminus DFGAsp-rot-in -132.69, 162.8 69.28, 95.13 199.49, -20.4 -109.8, 21.13 305.67, 104.94 -64.79, -17.76 in-in in 8.064 Saltbr-in 2.513 HRD-in -67.27, -48.59 64.56, -1.72 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.73, 166.78 APE9-dihe-na 120.3, 163.8 APE8-dihe-in -75.86, 125.98 APE8-rot-in 298.87 APE67-dihe-in -57.15, -29.94 -38.43, -48.34 APE12-dist-in 9.03 APE11-dist-in 12.294 APE10-dist-in 6.896 APE9-dist-in 3.767 None TPO538,SEP695 TPO538,SEP695 XRAY 2.0 0.201 0.216 A 345 282 0 0 0 0 [[380, 634]] 1.0 1xjd AGC_PRKCQ_HUMAN AGC 1.2e-95 325.5 1 260 260 521 522 523 525 527 409 428 432 501 503 502 504 561 549 544 543 542 541 540 539 538 459 Protein kinase C theta type
AGC PRKCZ KPCZ_HUMAN AF-Q05513-K1A Q05513 244 526 592.0 No_ligand No_ligand Active DFGin 5.247 12.248 BLAminus DFGAsp-rot-in -134.19, -169.05 47.75, 68.43 205.19, 24.54 -79.67, 13.11 309.63, 113.67 -62.25, -19.27 in-in in 8.664 Saltbr-in 2.594 HRD-in -77.28, -43.6 62.88, -6.04 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.51, 169.63 APE9-dihe-na 112.85, 164.61 APE8-dihe-in -71.33, 130.47 APE8-rot-in 295.97 APE67-dihe-in -66.67, -18.73 -48.34, -43.82 APE12-dist-in 8.54 APE11-dist-in 11.753 APE10-dist-in 6.085 APE9-dist-in 3.588 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[252, 518]] 1.0 AF-Q05513-K1 AGC_PRKCZ_HUMAN AGC 4.3e-94 320.4 1 260 260 393 394 395 397 399 281 300 304 373 375 374 376 433 421 416 415 414 413 412 411 410 331 Protein kinase C zeta type
AGC PRKCZ KPCZ_HUMAN AF-Q05513-K3A Q05513 244 526 592.0 No_ligand No_ligand Active DFGin 5.121 12.155 BLAminus DFGAsp-rot-in -132.86, -176.33 58.74, 76.35 202.54, 23.99 -87.97, 8.87 310.28, 134.34 -62.38, -20.23 in-in in 8.478 Saltbr-in 2.638 HRD-in -83.8, -41.61 66.03, -3.98 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 173.93 APE9-dihe-na 108.79, 169.21 APE8-dihe-in -80.7, 127.66 APE8-rot-in 291.97 APE67-dihe-in -62.23, -21.3 -45.38, -45.91 APE12-dist-in 8.892 APE11-dist-in 11.838 APE10-dist-in 6.182 APE9-dist-in 3.324 None None None AF2 -1.0 1.0 1.0 A 283 283 0 0 0 0 [[252, 518]] 1.0 AF-Q05513-K3 AGC_PRKCZ_HUMAN AGC 4.3e-94 320.4 1 260 260 393 394 395 397 399 281 300 304 373 375 374 376 433 421 416 415 414 413 412 411 410 331 Protein kinase C zeta type
AGC PRKG1 KGP1_HUMAN 7T4UA Q13976 205 671 671.0 EX6:69901 Allosteric Inactive DFGin 5.893 14.511 ABAminus DFGAsp-rot-in -110.98, -36.23 -113.94, 119.68 190.79, 3.65 -109.65, 38.15 284.57, 73.72 -68.19, -46.47 in-in in 9.753 Saltbr-in 2.944 HRD-in -80.27, -49.41 62.96, -11.31 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.82, 170.87 APE9-dihe-na 95.36, 163.3 APE8-dihe-in -65.83, 127.77 APE8-rot-in 297.19 APE67-dihe-in -61.65, -25.18 -50.5, -36.94 APE12-dist-in 8.302 APE11-dist-in 11.55 APE10-dist-in 5.886 APE9-dist-in 5.043 None TPO517 TPO517 XRAY 1.99 0.216 0.26 A 469 467 0 0 0 0 [[360, 619]] 1.0 7t4u AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4UB Q13976 205 671 671.0 EX6:69901 Allosteric Inactive DFGin 5.882 14.671 ABAminus DFGAsp-rot-in -116.42, -27.15 -112.65, 115.98 196.85, -18.75 -107.16, 33.12 284.12, 70.33 -62.23, -46.18 in-in in 9.761 Saltbr-in 2.921 HRD-in -79.97, -49.4 62.99, -11.71 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 162.77 APE9-dihe-na 104.48, 162.22 APE8-dihe-in -65.39, 128.54 APE8-rot-in 296.86 APE67-dihe-in -62.65, -24.95 -50.24, -36.77 APE12-dist-in 8.26 APE11-dist-in 11.573 APE10-dist-in 5.962 APE9-dist-in 5.014 None TPO517 TPO517 XRAY 1.99 0.216 0.26 B 469 461 0 0 0 0 [[360, 619]] 1.0 7t4u AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4WA Q13976 205 671 671.0 EZJ:69901 Allosteric Inactive DFGin 6.203 14.656 ABAminus DFGAsp-rot-out -120.51, -49.82 -94.54, 125.75 298.69, -12.15 -115.2, 38.22 287.71, 71.79 -69.94, -44.46 in-in in 9.868 Saltbr-in 3.462 HRD-in -82.07, -59.56 68.33, -9.38 in-in-in SNCiii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.57, 172.99 APE9-dihe-na 100.31, 156.35 APE8-dihe-in -58.55, 123.29 APE8-rot-in 292.59 APE67-dihe-in -70.67, -20.63 -47.72, -29.8 APE12-dist-in 8.075 APE11-dist-in 11.499 APE10-dist-in 6.222 APE9-dist-in 4.918 None TPO517 TPO517 XRAY 2.23 0.207 0.267 A 469 467 0 0 0 0 [[360, 619]] 1.0 7t4w AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4WB Q13976 205 671 671.0 EZJ:69901 Allosteric Inactive DFGin 6.167 14.645 ABAminus DFGAsp-rot-in -115.45, -45.68 -98.44, 117.3 239.27, -65.52 -111.38, 33.0 288.61, 72.93 -65.23, -44.36 in-in in 9.884 Saltbr-in 3.465 HRD-in -84.88, -51.35 65.14, -16.73 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 173.1 APE9-dihe-na 100.13, 155.73 APE8-dihe-in -59.24, 124.2 APE8-rot-in 292.57 APE67-dihe-in -70.75, -20.56 -47.95, -29.59 APE12-dist-in 8.086 APE11-dist-in 11.514 APE10-dist-in 6.25 APE9-dist-in 4.898 None TPO517 TPO517 XRAY 2.23 0.207 0.267 B 469 467 0 0 0 0 [[360, 619]] 1.0 7t4w AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TA Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.806 14.933 ABAminus DFGAsp-rot-in -123.17, -29.2 -107.96, 118.17 195.82, -29.37 -112.33, 30.1 285.53, 74.3 -67.24, -29.77 in-in in 9.557 Saltbr-in 3.38 HRD-in -86.67, -51.63 61.2, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.89, 164.61 APE9-dihe-na 124.7, -170.63 APE8-dihe-in -100.54, 134.31 APE8-rot-in 302.38 APE67-dihe-in -67.0, -27.98 -44.1, -43.89 APE12-dist-in 7.941 APE11-dist-in 10.713 APE10-dist-in 5.308 APE9-dist-in 3.712 None TPO517 TPO517 XRAY 2.08 0.19 0.221 A 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8 14.811 ABAminus DFGAsp-rot-in -121.38, -38.76 -100.76, 117.73 195.65, -29.65 -112.4, 30.34 285.48, 73.71 -68.75, -29.12 in-in in 9.401 Saltbr-in 3.311 HRD-in -86.82, -51.68 61.52, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.5, 164.27 APE9-dihe-na 124.32, -169.95 APE8-dihe-in -101.18, 134.26 APE8-rot-in 302.8 APE67-dihe-in -67.54, -26.94 -44.3, -44.01 APE12-dist-in 7.957 APE11-dist-in 10.757 APE10-dist-in 5.336 APE9-dist-in 3.717 None TPO517 TPO517 XRAY 2.08 0.19 0.221 B 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.811 14.714 BLAminus DFGAsp-rot-in -124.15, 169.14 66.07, 88.5 189.42, -2.31 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.522 Saltbr-in 2.883 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.235 APE11-dist-in 11.512 APE10-dist-in 6.041 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347 336 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.001 13.81 BLAminus DFGAsp-rot-in -122.67, 175.58 65.94, 84.43 190.65, 1.3 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.743 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.826 APE11-dist-in 11.215 APE10-dist-in 5.769 APE9-dist-in 4.008 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347 326 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.746 14.057 BLAminus DFGAsp-rot-in -122.99, 175.03 65.66, 84.22 189.65, 1.38 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.742 Saltbr-in 2.723 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.972 APE11-dist-in 11.385 APE10-dist-in 5.857 APE9-dist-in 3.861 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347 335 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.71 14.012 BLAminus DFGAsp-rot-in -124.49, 174.79 65.67, 84.87 190.77, 1.27 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.644 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.988 APE11-dist-in 11.327 APE10-dist-in 5.784 APE9-dist-in 3.81 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347 328 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.851 14.036 BLAminus DFGAsp-rot-in -116.97, 177.04 63.26, 88.72 193.0, 2.14 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.624 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.972 APE11-dist-in 11.057 APE10-dist-in 5.469 APE9-dist-in 3.811 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617 600 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.634 13.962 BLAminus DFGAsp-rot-in -116.52, 178.28 63.3, 90.17 189.2, 6.59 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.883 Saltbr-in 2.824 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.134 APE11-dist-in 11.198 APE10-dist-in 5.604 APE9-dist-in 3.787 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617 593 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4VA Q13976 205 671 671.0 EXZ:69901 Allosteric Inactive DFGin 6.18 14.758 BLAminus DFGAsp-rot-out -117.38, 165.11 68.06, 101.28 298.3, -44.95 -115.37, 45.06 282.61, 73.13 -70.13, -49.07 in-in in 9.838 Saltbr-in 2.979 HRD-in -86.09, -51.09 71.54, -55.93 in-in-out SNCiio in-out ActLoopNT-in 2.742 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -158.12, 169.74 APE9-dihe-na 104.56, 162.71 APE8-dihe-in -70.69, 125.48 APE8-rot-in 298.14 APE67-dihe-in -57.19, -28.82 -42.61, -42.82 APE12-dist-in 8.556 APE11-dist-in 11.714 APE10-dist-in 6.317 APE9-dist-out 6.031 None TPO517 TPO517 XRAY 2.28 0.197 0.256 A 469 467 0 0 0 0 [[360, 619]] 1.0 7t4v AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4VB Q13976 205 671 671.0 EXZ:69901 Allosteric Inactive DFGin 6.191 14.848 BLAminus DFGAsp-rot-out -117.12, 164.99 68.84, 100.49 290.83, -30.03 -114.63, 44.2 282.85, 73.02 -69.55, -49.58 in-in in 9.876 Saltbr-in 3.02 HRD-in -85.46, -53.89 74.22, -39.6 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.05, 169.08 APE9-dihe-na 104.88, 162.74 APE8-dihe-in -71.34, 125.86 APE8-rot-in 297.46 APE67-dihe-in -57.61, -28.56 -42.75, -43.02 APE12-dist-in 8.264 APE11-dist-in 11.663 APE10-dist-in 6.268 APE9-dist-in 5.216 None TPO517 TPO517 XRAY 2.28 0.197 0.256 B 469 464 0 0 0 0 [[360, 619]] 1.0 7t4v AGC_PRKG1_HUMAN AGC 6.6e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN AF-Q13976-K1A Q13976 352 627 671.0 No_ligand No_ligand Active DFGin 6.271 14.18 BLAminus DFGAsp-rot-in -115.7, -171.89 41.6, 86.13 204.02, -3.4 -92.63, 18.96 285.01, 78.59 -59.54, -30.9 in-in in 9.607 Saltbr-in 2.712 HRD-in -90.69, -50.22 66.05, 7.72 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.15, 172.71 APE9-dihe-na 108.43, 171.02 APE8-dihe-in -80.49, 129.57 APE8-rot-in 300.74 APE67-dihe-in -68.04, -21.28 -48.8, -41.85 APE12-dist-in 8.214 APE11-dist-in 11.197 APE10-dist-in 5.629 APE9-dist-in 3.53 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[360, 619]] 1.0 AF-Q13976-K1 AGC_PRKG1_HUMAN AGC 1.2e-84 289.4 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN AF-Q13976-K3A Q13976 352 627 671.0 No_ligand No_ligand Active DFGin 5.906 13.923 BLAminus DFGAsp-rot-in -115.45, -173.31 41.39, 87.3 204.92, 2.57 -90.8, 19.58 282.99, 76.21 -58.78, -31.1 in-in in 9.248 Saltbr-in 2.714 HRD-in -91.17, -53.27 69.22, 14.91 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.96, 169.62 APE9-dihe-na 104.72, 167.78 APE8-dihe-in -75.94, 135.6 APE8-rot-in 283.37 APE67-dihe-in -66.68, -21.92 -49.58, -45.16 APE12-dist-in 7.888 APE11-dist-in 11.013 APE10-dist-in 5.444 APE9-dist-in 3.338 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[360, 619]] 1.0 AF-Q13976-K3 AGC_PRKG1_HUMAN AGC 1.2e-84 289.4 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BDLA Q13976 337 671 671.0 No_ligand No_ligand Inactive DFGin 5.713 14.513 BLAminus DFGAsp-rot-in -122.27, 166.18 66.21, 96.03 193.51, 8.66 -109.78, 28.36 280.09, 66.52 -59.53, -32.57 in-in in 9.565 Saltbr-in 2.712 HRD-in -93.15, -47.43 77.49, -41.85 in-in-out SNCiio in-out ActLoopNT-in 2.821 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -113.85, 160.0 APE9-dihe-na 86.62, 160.7 APE8-dihe-in -68.44, 153.87 APE8-rot-none 999.0 APE67-dihe-in -67.03, -17.86 -55.61, -25.3 APE12-dist-in 7.765 APE11-dist-in 11.218 APE10-dist-in 5.604 APE9-dist-out 6.231 None TPO517 TPO517 XRAY 1.96 0.209 0.222 A 347 335 0 0 0 0 [[360, 619]] 1.0 6bdl AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BDLB Q13976 337 671 671.0 No_ligand No_ligand None DFGin 5.757 14.658 BLAminus DFGAsp-rot-in -124.78, 164.72 65.46, 95.48 191.95, 8.91 -109.07, 28.23 278.78, 64.61 -59.31, -33.14 in-in in 9.337 Saltbr-in 2.902 HRD-in -92.19, -47.19 78.26, -40.54 in-in-none SNCiin in-none ActLoopNT-in 2.877 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -122.13, 167.41 APE9-dihe-na 91.21, 161.43 APE8-dihe-in -67.63, 145.68 APE8-rot-none 999.0 APE67-dihe-in -70.27, -17.78 -60.28, -30.02 APE12-dist-in 7.598 APE11-dist-in 11.396 APE10-dist-in 5.795 APE9-dist-in 5.468 None TPO517 TPO517 XRAY 1.96 0.209 0.222 B 347 335 0 0 0 0 [[360, 619]] 1.0 6bdl AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6C0TA Q13976 337 671 671.0 EE4:701 Type1.5_Front Inactive DFGin 5.9 14.257 BLAminus DFGAsp-rot-out -131.41, 173.3 67.52, 81.76 264.71, -7.5 -101.27, 23.85 278.07, 65.63 -65.26, -23.23 in-in in 8.935 Saltbr-in 2.797 HRD-in -100.02, -51.71 77.78, -11.77 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.5, 158.55 APE9-dihe-na 107.94, 162.3 APE8-dihe-in -69.48, 141.18 APE8-rot-out 79.81 APE67-dihe-in -72.66, -16.0 -52.58, -33.36 APE12-dist-in 7.74 APE11-dist-in 11.364 APE10-dist-in 5.987 APE9-dist-in 4.819 None TPO517 TPO517 XRAY 1.98 0.21 0.244 A 347 335 0 0 0 0 [[360, 619]] 1.0 6c0t AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG2 KGP2_HUMAN AF-Q13237-K1A Q13237 445 719 762.0 No_ligand No_ligand Active DFGin 6.752 14.082 BLAminus DFGAsp-rot-in -119.48, -168.56 40.28, 72.03 204.36, 20.64 -81.07, 22.48 279.52, 70.99 -61.25, -29.42 in-in in 9.097 Saltbr-in 2.634 HRD-in -88.44, -50.44 65.17, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.09, 174.87 APE9-dihe-na 104.38, 165.11 APE8-dihe-in -75.18, 129.23 APE8-rot-in 301.17 APE67-dihe-in -67.52, -20.75 -48.21, -43.33 APE12-dist-in 7.965 APE11-dist-in 11.192 APE10-dist-in 5.565 APE9-dist-in 3.516 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[453, 711]] 1.0 AF-Q13237-K1 AGC_PRKG2_HUMAN AGC 3.4e-83 284.7 2 259 258 593 594 595 597 599 482 501 505 573 575 574 576 632 620 615 614 613 612 611 610 609 531 cGMP-dependent protein kinase 2
AGC PRKG2 KGP2_HUMAN AF-Q13237-K3A Q13237 445 719 762.0 No_ligand No_ligand Active DFGin 6.502 14.153 BLAminus DFGAsp-rot-in -125.77, -178.87 48.72, 84.0 207.66, 5.43 -89.45, 17.56 282.99, 76.2 -58.9, -27.76 in-in in 9.096 Saltbr-in 2.644 HRD-in -88.18, -50.21 69.86, 1.4 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.03, 171.58 APE9-dihe-na 102.04, 166.89 APE8-dihe-in -72.95, 132.54 APE8-rot-in 286.13 APE67-dihe-in -67.36, -20.13 -48.32, -44.14 APE12-dist-in 7.685 APE11-dist-in 10.986 APE10-dist-in 5.484 APE9-dist-in 3.725 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[453, 711]] 1.0 AF-Q13237-K3 AGC_PRKG2_HUMAN AGC 3.4e-83 284.7 2 259 258 593 594 595 597 599 482 501 505 573 575 574 576 632 620 615 614 613 612 611 610 609 531 cGMP-dependent protein kinase 2
AGC PRKX PRKX_HUMAN AF-P51817-K1A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.667 14.553 BLAminus DFGAsp-rot-in -121.72, -174.69 49.59, 81.61 199.0, -12.13 -95.04, 16.66 288.42, 82.22 -70.51, -23.61 in-in in 8.911 Saltbr-in 2.708 HRD-in -86.78, -47.49 65.73, 2.37 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.15, 159.34 APE9-dihe-na 109.64, 178.29 APE8-dihe-in -81.97, 127.99 APE8-rot-in 303.22 APE67-dihe-in -65.66, -24.04 -47.75, -43.09 APE12-dist-in 8.315 APE11-dist-in 11.312 APE10-dist-in 5.621 APE9-dist-in 3.592 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K1 AGC_PRKX_HUMAN AGC 5.6e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
AGC PRKX PRKX_HUMAN AF-P51817-K3A P51817 41 311 358.0 No_ligand No_ligand Active DFGin 6.24 14.365 BLAminus DFGAsp-rot-in -126.23, -173.14 47.02, 78.73 201.67, -14.04 -87.6, 16.57 289.31, 79.51 -57.8, -34.93 in-in in 8.808 Saltbr-in 2.688 HRD-in -84.22, -46.74 70.42, -1.61 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.47, 160.07 APE9-dihe-na 104.92, 173.58 APE8-dihe-in -75.13, 134.82 APE8-rot-in 294.67 APE67-dihe-in -64.87, -22.2 -48.45, -44.36 APE12-dist-in 7.788 APE11-dist-in 11.149 APE10-dist-in 5.605 APE9-dist-in 4.253 None None None AF2 -1.0 1.0 1.0 A 271 271 0 0 0 0 [[49, 303]] 1.0 AF-P51817-K3 AGC_PRKX_HUMAN AGC 5.6e-91 310.2 1 260 260 189 190 191 193 195 78 97 101 169 171 170 172 226 214 209 208 207 206 205 204 203 127 cAMP-dependent protein kinase catalytic subunit PRKX
AGC ROCK1 ROCK1_HUMAN 3NDMA Q13464 6 402 1354.0 No_ligand No_ligand Inactive DFGin 5.598 13.058 ABAminus DFGAsp-rot-in -120.89, -34.04 -109.2, 148.34 207.98, -40.19 -142.38, 4.69 304.49, 84.24 -63.88, 57.85 in-out in 9.076 Saltbr-out 3.763 HRD-in -57.38, -56.5 79.4, 26.69 out-in-in SNCoii in-in ActLoopNT-in 3.157 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.05, 156.15 APE9-dihe-na 131.42, -138.04 APE8-dihe-in -125.51, 139.35 APE8-rot-in 275.81 APE67-dihe-in -57.52, -0.48 -48.9, -63.05 APE12-dist-in 10.485 APE11-dist-in 11.171 APE10-dist-in 5.509 APE9-dist-in 4.003 None None None XRAY 3.3 0.244 0.31 A 415 382 11 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NCZA Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.335 13.775 ABAminus DFGAsp-rot-in -116.14, -12.55 -138.55, 134.31 171.65, -60.94 -126.47, 14.42 296.82, 87.82 -51.46, -39.63 in-in in 9.306 Saltbr-in 3.537 HRD-in -78.05, -50.28 73.4, -14.49 in-in-in SNCiii in-in ActLoopNT-in 3.161 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.89, -176.36 APE9-dihe-na 133.28, -167.86 APE8-dihe-in -125.48, 134.73 APE8-rot-in 280.08 APE67-dihe-in -84.68, -47.89 -24.91, -55.61 APE12-dist-in 12.595 APE11-dist-in 10.072 APE10-dist-in 5.448 APE9-dist-in 3.551 None None None XRAY 3.0 0.259 0.328 A 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NCZB Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.168 13.439 ABAminus DFGAsp-rot-in -114.85, -16.66 -131.56, 138.9 181.88, -51.33 -136.04, 17.21 298.24, 65.97 -58.26, -38.43 in-in in 9.313 Saltbr-in 2.492 HRD-in -79.75, -44.81 74.12, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, -112.01 APE9-dihe-na -175.97, -67.78 APE8-dihe-in -149.88, 165.72 APE8-rot-out 209.54 APE67-dihe-in -50.79, -11.63 -86.98, -72.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.143 APE9-dist-in 4.977 None None None XRAY 3.0 0.259 0.328 B 415 377 15 0 0 2 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NCZC Q13464 6 404 1354.0 3NC:60900 Type1 Inactive DFGin 5.957 13.35 ABAminus DFGAsp-rot-in -116.08, -7.73 -136.42, 136.67 178.62, 83.4 -131.83, 24.74 306.96, 86.44 -58.54, -34.95 in-in in 9.223 Saltbr-in 3.491 HRD-in -83.49, -46.62 73.83, -20.27 in-in-in SNCiii in-in ActLoopNT-in 3.156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.05, 125.19 APE9-dihe-na 160.07, -158.87 APE8-dihe-in -144.7, 128.84 APE8-rot-in 311.05 APE67-dihe-in -25.99, -52.32 -21.36, -99.97 APE12-dist-in 10.188 APE11-dist-in 11.672 APE10-dist-in 5.728 APE9-dist-in 3.595 None None None XRAY 3.0 0.259 0.328 C 415 387 6 0 0 1 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NCZD Q13464 6 402 1354.0 3NC:60900 Type1 Inactive DFGin 6.007 13.398 ABAminus DFGAsp-rot-in -130.28, 7.59 -144.4, 127.27 185.39, -53.59 -129.17, 19.34 304.27, 91.75 -57.04, -39.11 in-in in 9.214 Saltbr-in 3.563 HRD-in -74.16, -50.68 74.64, -10.85 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.26, 158.97 APE9-dihe-na 125.95, -146.31 APE8-dihe-in -122.54, 128.42 APE8-rot-in 314.26 APE67-dihe-in -57.68, -28.69 -36.8, -72.93 APE12-dist-in 12.398 APE11-dist-in 11.269 APE10-dist-in 6.343 APE9-dist-in 4.414 None None None XRAY 3.0 0.259 0.328 D 415 397 0 0 0 0 [[76, 338]] 1.0 3ncz AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NDMB Q13464 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.577 13.291 ABAminus DFGAsp-rot-in -135.55, -20.22 -111.5, 137.71 206.05, -34.51 -126.94, 16.16 300.9, 101.92 -51.55, 28.77 in-in in 9.054 Saltbr-in 3.139 HRD-in -67.67, -67.76 85.4, 21.53 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.13, 142.73 APE9-dihe-na 132.91, -126.28 APE8-dihe-in -146.05, 131.58 APE8-rot-out 3.64 APE67-dihe-in -75.87, -9.86 -31.39, -53.34 APE12-dist-in 10.706 APE11-dist-in 11.097 APE10-dist-in 5.491 APE9-dist-in 3.782 None None None XRAY 3.3 0.244 0.31 B 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NDMC Q13464 6 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.992 13.635 ABAminus DFGAsp-rot-in -126.83, -28.62 -112.07, 139.0 238.7, -78.51 -136.27, 9.02 298.66, 85.88 -64.37, 58.3 in-in in 9.095 Saltbr-in 2.606 HRD-in -61.33, -59.76 82.3, 14.91 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.83 APE8-rot-in 289.24 APE67-dihe-in -57.51, 0.5 -55.13, -56.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.244 0.31 C 415 370 27 0 0 5 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3NDMD Q13464 7 402 1354.0 3ND:60900 Type1 Inactive DFGin 5.558 12.915 ABAminus DFGAsp-rot-in -131.86, -23.53 -116.86, 142.93 232.62, -74.18 -139.56, 15.34 308.38, 98.2 -65.61, 50.23 in-in in 8.897 Saltbr-in 3.292 HRD-in -62.78, -65.01 82.89, 25.17 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 144.78 APE9-dihe-na 137.32, -133.95 APE8-dihe-in -135.6, 138.94 APE8-rot-in 312.66 APE67-dihe-in -58.83, -6.42 -51.7, -57.53 APE12-dist-in 10.726 APE11-dist-in 11.123 APE10-dist-in 5.525 APE9-dist-in 3.966 None None None XRAY 3.3 0.244 0.31 D 415 396 0 0 0 0 [[76, 338]] 1.0 3ndm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNFA Q13464 7 401 1354.0 B4V:60501 Type1 Inactive DFGin 6.037 13.819 ABAminus DFGAsp-rot-in -112.9, -18.08 -125.42, 134.15 206.79, -83.39 -136.13, 27.61 308.44, 98.66 -67.13, -15.25 in-in in 9.248 Saltbr-in 2.85 HRD-in -71.62, -55.08 69.7, 8.34 in-in-out SNCiio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.82, 159.62 APE9-dihe-na 114.62, -153.36 APE8-dihe-in -121.99, 142.9 APE8-rot-out 46.24 APE67-dihe-in -85.9, -24.36 -50.23, -33.75 APE12-dist-in 10.846 APE11-dist-in 11.24 APE10-dist-in 5.38 APE9-dist-in 3.488 None None None XRAY 2.45 0.237 0.247 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNFB Q13464 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.01 13.809 ABAminus DFGAsp-rot-in -112.8, -19.42 -121.66, 133.79 207.69, -83.89 -135.75, 27.87 308.04, 98.76 -66.99, -15.52 in-in in 9.203 Saltbr-in 2.829 HRD-in -56.58, -57.45 66.78, 9.49 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.62 APE8-rot-out 185.84 APE67-dihe-out -96.25, -5.58 -76.73, 157.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.45 0.237 0.247 B 415 357 30 0 0 7 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNFC Q13464 6 402 1354.0 B4V:60900 Type1 Inactive DFGin 6.053 13.734 ABAminus DFGAsp-rot-in -112.34, -18.7 -124.86, 134.18 207.22, -83.94 -135.55, 28.39 308.28, 99.0 -66.12, -17.35 in-in in 9.167 Saltbr-in 2.825 HRD-in -54.29, -57.6 67.49, 9.1 in-in-out SNCiio in-out ActLoopNT-in 3.113 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.13, 155.5 APE9-dihe-na 100.24, 173.54 APE8-dihe-in -65.25, 143.72 APE8-rot-out 166.74 APE67-dihe-in -84.72, -32.31 -63.88, -30.83 APE12-dist-in 10.866 APE11-dist-in 11.263 APE10-dist-in 5.395 APE9-dist-in 3.711 None None None XRAY 2.45 0.237 0.247 C 415 384 9 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNFD Q13464 7 402 1354.0 B4V:60900 Type1 Inactive DFGin 5.998 13.798 ABAminus DFGAsp-rot-in -116.97, -16.71 -124.97, 134.65 205.96, -83.57 -136.46, 28.19 307.91, 98.81 -65.17, -16.17 in-in in 9.272 Saltbr-in 2.853 HRD-in -65.28, -52.76 63.38, 9.16 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.89, 153.13 APE9-dihe-na 122.32, -150.94 APE8-dihe-in -121.83, 134.39 APE8-rot-in 304.55 APE67-dihe-in -67.21, -32.35 -51.49, -41.1 APE12-dist-in 10.448 APE11-dist-in 11.406 APE10-dist-in 5.498 APE9-dist-in 3.771 None None None XRAY 2.45 0.237 0.247 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wnf AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNGA Q13464 7 401 1354.0 B4Y:60900 Type1 Inactive DFGin 5.977 13.509 ABAminus DFGAsp-rot-in -104.78, -47.26 -102.37, 133.32 178.7, -88.38 -128.78, 19.38 307.6, 97.01 -57.06, -32.21 in-in in 8.889 Saltbr-in 2.786 HRD-in -66.26, -51.49 72.53, -8.5 in-in-out SNCiio in-out ActLoopNT-in 3.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.53, 147.93 APE9-dihe-na 135.56, -145.58 APE8-dihe-in -132.84, 135.01 APE8-rot-out 33.77 APE67-dihe-in -86.48, -37.64 -34.31, -39.64 APE12-dist-in 11.061 APE11-dist-in 11.37 APE10-dist-in 5.558 APE9-dist-in 3.703 None None None XRAY 2.9 0.231 0.25 A 415 395 0 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNGB Q13464 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.115 13.674 ABAminus DFGAsp-rot-in -116.66, -65.65 -74.59, 116.95 197.1, 5.65 -121.4, 25.51 300.62, 111.42 -66.75, -32.14 in-in in 8.63 Saltbr-in 2.816 HRD-in -60.46, -50.75 69.34, -5.89 in-in-out SNCiio in-out ActLoopNT-in 2.974 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.6 APE8-rot-out 38.45 APE67-dihe-out -117.81, -1.71 -74.02, 169.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.231 0.25 B 415 364 23 0 0 7 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNGC Q13464 6 402 1354.0 B4Y:60900 Type1 Inactive DFGin 6.25 13.699 ABAminus DFGAsp-rot-in -112.13, -65.71 -71.21, 131.58 210.48, -19.18 -134.73, 15.31 296.94, 115.81 -61.29, -33.48 in-in in 8.745 Saltbr-in 2.902 HRD-in -54.07, -49.11 68.03, -4.17 in-in-out SNCiio in-out ActLoopNT-in 3.254 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.49, 151.91 APE9-dihe-na 125.81, -139.62 APE8-dihe-in -129.94, 140.76 APE8-rot-out 193.11 APE67-dihe-in -90.91, -38.38 -54.59, -19.55 APE12-dist-in 12.025 APE11-dist-in 11.331 APE10-dist-in 5.506 APE9-dist-in 3.78 None None None XRAY 2.9 0.231 0.25 C 415 385 9 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNGD Q13464 7 402 1354.0 B4Y:60900 Type1 Inactive DFGin 5.966 13.648 ABAminus DFGAsp-rot-in -112.91, -68.51 -77.11, 128.39 197.99, -25.36 -125.32, 34.85 304.06, 106.91 -57.33, -48.7 in-in in 8.582 Saltbr-in 2.835 HRD-in -67.41, -43.54 61.42, -5.48 in-in-in SNCiii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.21, 150.67 APE9-dihe-na 129.52, -151.03 APE8-dihe-in -111.91, 139.64 APE8-rot-in 301.32 APE67-dihe-in -86.26, -34.21 -63.2, -20.63 APE12-dist-in 10.285 APE11-dist-in 11.038 APE10-dist-in 5.199 APE9-dist-in 3.783 None None None XRAY 2.9 0.231 0.25 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wng AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNHA Q13464 6 401 1354.0 B5G:60900 Type1 Inactive DFGin 6.254 14.084 ABAminus DFGAsp-rot-in -126.85, -43.1 -92.25, 105.27 176.0, 79.72 -105.51, 23.43 302.78, 98.53 -79.59, -3.09 in-in in 9.245 Saltbr-in 2.798 HRD-in -66.14, -40.5 59.01, 4.04 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 140.18 APE9-dihe-na 145.92, -147.99 APE8-dihe-in -117.87, 133.55 APE8-rot-in 336.48 APE67-dihe-in -88.84, -32.74 -46.05, -33.53 APE12-dist-in 10.997 APE11-dist-in 11.645 APE10-dist-in 5.826 APE9-dist-in 3.569 None None None XRAY 3.1 0.227 0.234 A 415 394 0 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNHB Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.144 13.78 ABAminus DFGAsp-rot-in -129.47, -54.81 -79.68, 115.69 194.44, 48.38 -121.99, 26.51 302.73, 109.7 -73.56, -13.31 in-in in 8.705 Saltbr-in 2.821 HRD-in -59.34, -49.1 69.57, -2.06 in-in-out SNCiio in-out ActLoopNT-in 3.304 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.34 APE8-rot-in 317.54 APE67-dihe-out -81.13, -17.85 -72.96, 161.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.227 0.234 B 415 364 27 0 0 7 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNHC Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 6.194 13.467 ABAminus DFGAsp-rot-in -129.17, -51.51 -79.99, 119.08 193.33, 47.66 -126.12, 27.06 305.6, 119.19 -74.43, -19.79 in-in in 8.756 Saltbr-in 2.816 HRD-in -53.22, -44.09 64.75, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.334 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.33, 164.22 APE9-dihe-na 88.42, -167.51 APE8-dihe-in -97.64, 151.48 APE8-rot-out 44.44 APE67-dihe-in -84.21, -19.91 -62.02, -38.65 APE12-dist-in 10.409 APE11-dist-in 11.594 APE10-dist-in 5.513 APE9-dist-in 4.157 None None None XRAY 3.1 0.227 0.234 C 415 386 9 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNHD Q13464 6 402 1354.0 B5G:60900 Type1 Inactive DFGin 5.961 13.847 ABAminus DFGAsp-rot-in -129.74, -51.1 -87.04, 108.6 197.33, 28.68 -110.61, 24.81 306.94, 102.01 -68.9, -6.61 in-in in 8.789 Saltbr-in 2.815 HRD-in -59.28, -47.58 67.24, -1.66 in-in-in SNCiii in-in ActLoopNT-in 3.261 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.57, 150.52 APE9-dihe-na 117.79, -157.18 APE8-dihe-in -100.56, 138.22 APE8-rot-in 307.58 APE67-dihe-in -71.46, -24.96 -63.42, -32.46 APE12-dist-in 10.637 APE11-dist-in 11.182 APE10-dist-in 5.325 APE9-dist-in 4.172 None None None XRAY 3.1 0.227 0.234 D 415 397 0 0 0 0 [[76, 338]] 1.0 5wnh AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 6E9WA Q13464 9 404 1354.0 J0P:501 Type1 Inactive DFGin 5.94 12.907 ABAminus DFGAsp-rot-in -138.73, -20.79 -111.43, 114.1 186.95, -16.4 -109.17, 19.11 307.72, 100.2 -59.06, -19.52 in-in in 8.74 Saltbr-in 2.804 HRD-in -69.49, -44.89 71.41, -17.92 in-in-in SNCiii in-in ActLoopNT-in 3.053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 148.51 APE9-dihe-na 125.0, -143.28 APE8-dihe-in -119.0, 136.17 APE8-rot-in 293.48 APE67-dihe-in -80.63, -46.93 -50.48, -33.35 APE12-dist-in 11.461 APE11-dist-in 11.324 APE10-dist-in 5.617 APE9-dist-in 4.16 None None None XRAY 2.96 0.197 0.255 A 443 383 5 0 0 0 [[76, 338]] 1.0 6e9w AGC_ROCK1_HUMAN AGC 4.4e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 6E9WB Q13464 7 401 1354.0 J0P:501 Type1 Inactive DFGin 6.131 13.232 ABAminus DFGAsp-rot-in -138.25, -17.0 -112.71, 103.23 172.89, 21.83 -100.64, 12.5 302.93, 104.22 -62.68, -19.69 in-in in 8.572 Saltbr-in 2.859 HRD-in -74.05, -53.13 88.59, -33.91 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -80.59, -50.75 APE9-dihe-na 100.48, -142.0 APE8-dihe-in -66.64, 110.65 APE8-rot-in 303.29 APE67-dihe-in -27.98, -53.24 -75.85, -16.15 APE12-dist-in 9.367 APE11-dist-in 11.627 APE10-dist-out 9.912 APE9-dist-out 10.033 None None None XRAY 2.96 0.197 0.255 B 443 380 9 0 0 0 [[76, 338]] 1.0 6e9w AGC_ROCK1_HUMAN AGC 4.4e-94 320.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus DFGAsp-rot-in -137.29, -177.31 60.22, 109.9 175.76, 18.16 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus DFGAsp-rot-in -137.56, -177.44 62.15, 108.48 175.21, 17.4 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.4e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN AF-Q13464-K1A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 6.006 13.066 BLAminus DFGAsp-rot-in -137.66, -178.75 47.45, 69.34 200.5, 17.15 -81.8, 16.56 305.27, 105.28 -65.56, -12.08 in-in in 8.552 Saltbr-in 2.624 HRD-in -74.85, -46.42 64.04, 4.32 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.58, 160.73 APE9-dihe-na 98.63, 175.06 APE8-dihe-in -68.34, 133.89 APE8-rot-in 288.19 APE67-dihe-in -75.11, -22.05 -52.44, -39.16 APE12-dist-in 10.159 APE11-dist-in 11.26 APE10-dist-in 5.393 APE9-dist-in 3.726 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K1 AGC_ROCK1_HUMAN AGC 9.5e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN AF-Q13464-K3A Q13464 68 346 1354.0 No_ligand No_ligand Active DFGin 5.851 13.271 BLAminus DFGAsp-rot-in -137.07, 179.96 52.49, 70.51 204.01, 13.06 -80.48, 13.64 307.69, 107.27 -65.8, -8.31 in-in in 8.833 Saltbr-in 2.683 HRD-in -84.07, -47.73 66.69, 2.67 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.35, 143.29 APE9-dihe-na 121.73, 178.17 APE8-dihe-in -80.88, 131.47 APE8-rot-in 300.07 APE67-dihe-in -72.64, -15.78 -48.59, -46.75 APE12-dist-in 10.802 APE11-dist-in 11.642 APE10-dist-in 5.871 APE9-dist-in 3.256 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[76, 338]] 1.0 AF-Q13464-K3 AGC_ROCK1_HUMAN AGC 9.5e-95 322.5 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26D Q13464 6 399 1354.0 No_ligand No_ligand Inactive DFGin 5.74 13.393 BLAminus DFGAsp-rot-in -135.63, 169.88 65.28, 102.89 176.57, 65.02 -126.18, 46.78 310.06, 94.0 -59.95, -48.52 in-in in 8.609 Saltbr-in 2.712 HRD-out -94.12, 104.52 -83.22, 26.33 in-in-none SNCiin in-none ActLoopNT-in 3.224 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 D 398 256 101 0 0 23 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 8ZH5A Q13464 6 402 1354.0 No_ligand No_ligand Inactive DFGin 6.201 13.812 BLAminus DFGAsp-rot-in -163.2, 177.92 63.74, 56.57 208.88, -60.47 -85.06, 72.84 297.86, 127.64 -89.2, 164.53 in-in in 8.883 Saltbr-in 3.084 HRD-out -68.24, 147.42 -129.11, 149.32 in-in-none SNCiin in-none ActLoopNT-in 3.111 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.61, -8.47 999.0, -57.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.7 0.211 0.26 A 414 381 16 0 0 5 [[76, 338]] 1.0 8zh5 AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26A Q13464 6 401 1354.0 86K:60502 Type1 Inactive DFGin 6.073 13.254 BLAminus DFGAsp-rot-in -148.44, 169.09 78.33, 71.17 195.05, -11.11 -104.66, 28.05 312.23, 117.85 -62.26, -27.27 in-in in 8.513 Saltbr-in 2.743 HRD-in -60.15, -37.69 63.03, -7.84 in-in-out SNCiio in-out ActLoopNT-in 3.164 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.5 APE8-rot-out 189.11 APE67-dihe-in -62.34, -32.49 -61.49, -27.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 A 398 387 9 0 0 6 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26B Q13464 6 402 1354.0 86K:60502 Type1 None DFGin 5.894 13.466 BLAminus DFGAsp-rot-in -142.81, 170.64 62.27, 84.33 180.92, 6.5 -99.22, -25.13 305.67, 98.88 -149.72, 999.0 in-in in 8.694 Saltbr-in 2.732 HRD-in -65.9, -38.81 79.64, -62.78 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.9, -32.72 999.0, -32.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 B 398 372 19 0 0 19 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TV7A Q13464 9 402 1354.0 07Q:1 Type1 Inactive DFGin 6.141 13.462 BLAminus DFGAsp-rot-in -126.35, -171.09 45.97, 69.47 185.49, 15.53 -88.78, 8.65 301.41, 82.65 -54.6, -19.4 in-in in 8.749 Saltbr-in 2.566 HRD-out -65.46, -38.18 49.28, -142.26 in-in-out SNCiio in-out ActLoopNT-in 2.77 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -117.48, 157.83 APE9-dihe-na -63.36, -178.67 APE8-dihe-out 60.06, 84.52 APE8-rot-out 58.98 APE67-dihe-in -61.64, -35.43 -43.45, -41.95 APE12-dist-in 11.239 APE11-dist-in 11.898 APE10-dist-in 6.024 APE9-dist-out 8.376 None None None XRAY 2.75 0.205 0.253 A 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TV7B Q13464 6 402 1354.0 07Q:2 Type1 Inactive DFGin 5.857 13.2 BLAminus DFGAsp-rot-in -126.47, -172.51 48.84, 75.23 185.73, 21.43 -91.42, 11.14 311.64, 99.6 -51.14, -22.86 in-in in 8.601 Saltbr-in 2.832 HRD-in -67.51, -48.56 77.38, -23.22 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.19, 116.98 APE9-dihe-na -63.15, 117.97 APE8-dihe-out 61.18, 138.65 APE8-rot-out 58.98 APE67-dihe-in -71.45, -48.06 -97.86, 39.1 APE12-dist-out 6.296 APE11-dist-in 10.372 APE10-dist-out 8.735 APE9-dist-out 9.993 None None None XRAY 2.75 0.205 0.253 B 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TV7C Q13464 9 402 1354.0 07Q:3 Type1 Inactive DFGin 5.995 13.057 BLAminus DFGAsp-rot-in -112.83, -173.21 51.38, 70.56 201.25, 11.2 -91.09, 10.07 312.0, 83.09 -58.15, -16.34 in-in in 8.646 Saltbr-in 2.603 HRD-out -60.51, -40.04 50.0, -144.78 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -114.03, 172.25 APE9-dihe-na -61.19, 179.57 APE8-dihe-out 57.96, 81.04 APE8-rot-in 298.99 APE67-dihe-in -60.89, -34.02 -49.59, -35.58 APE12-dist-in 10.411 APE11-dist-in 11.832 APE10-dist-in 5.904 APE9-dist-out 7.951 None None None XRAY 2.75 0.205 0.253 C 410 394 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TV7D Q13464 6 402 1354.0 07Q:4 Type1 Inactive DFGin 6.01 13.388 BLAminus DFGAsp-rot-in -132.56, -173.08 50.96, 76.18 194.32, 15.35 -95.18, 10.41 310.62, 100.91 -52.21, -21.09 in-in in 8.623 Saltbr-in 2.97 HRD-in -71.89, -52.06 76.5, -19.27 in-in-out SNCiio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oioo APE10-dihe-na -125.31, 112.9 APE9-dihe-na -69.4, 112.01 APE8-dihe-out 62.52, 139.7 APE8-rot-in 314.53 APE67-dihe-in -45.86, -52.51 -76.31, -19.81 APE12-dist-out 5.556 APE11-dist-in 10.055 APE10-dist-out 9.448 APE9-dist-out 9.176 None None None XRAY 2.75 0.205 0.253 D 410 397 0 0 0 0 [[76, 338]] 1.0 3tv7 AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3V8SA Q13464 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.144 13.365 BLAminus DFGAsp-rot-out -131.47, 179.47 60.6, 71.6 288.43, -0.91 -93.5, 10.81 305.1, 96.77 -59.12, -15.76 in-in in 8.804 Saltbr-in 2.742 HRD-in -66.59, -53.55 76.27, -10.47 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.49, 177.7 APE9-dihe-na 96.83, -154.47 APE8-dihe-in -129.74, 143.67 APE8-rot-out 110.69 APE67-dihe-in -64.74, -31.71 -49.91, -44.47 APE12-dist-in 10.402 APE11-dist-in 11.776 APE10-dist-in 5.941 APE9-dist-in 3.727 None None None XRAY 2.286 0.188 0.236 A 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3V8SB Q13464 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.313 13.649 BLAminus DFGAsp-rot-out -129.24, 179.74 58.53, 76.73 296.65, -17.94 -94.51, 12.02 303.63, 98.77 -47.53, -31.19 in-in in 8.826 Saltbr-in 3.279 HRD-in -71.19, -49.28 79.11, -22.55 in-in-out SNCiio in-out ActLoopNT-in 2.975 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -114.6, -175.49 APE9-dihe-na -78.94, -129.14 APE8-dihe-in -42.78, 130.14 APE8-rot-in 309.49 APE67-dihe-in -49.83, -43.8 -72.71, -13.77 APE12-dist-out 6.676 APE11-dist-in 10.194 APE10-dist-in 7.063 APE9-dist-out 9.407 None None None XRAY 2.286 0.188 0.236 B 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3V8SC Q13464 8 402 1354.0 0HD:501 Type1 Inactive DFGin 6.229 13.48 BLAminus DFGAsp-rot-out -131.94, 178.46 61.35, 70.46 290.48, 2.75 -92.71, 10.99 301.74, 97.6 -57.75, -20.03 in-in in 8.789 Saltbr-in 2.919 HRD-in -68.58, -53.3 74.86, -10.72 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.32, 170.47 APE9-dihe-na 100.83, -158.56 APE8-dihe-in -121.14, 144.0 APE8-rot-out 104.69 APE67-dihe-in -65.81, -32.6 -49.38, -42.89 APE12-dist-in 10.322 APE11-dist-in 11.73 APE10-dist-in 5.877 APE9-dist-in 3.799 None None None XRAY 2.286 0.188 0.236 C 410 395 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3V8SD Q13464 6 402 1354.0 0HD:501 Type1 Inactive DFGin 6.274 13.681 BLAminus DFGAsp-rot-out -134.51, 177.57 58.27, 76.4 292.31, -20.43 -93.55, 11.58 303.68, 94.09 -46.72, -30.67 in-in in 8.887 Saltbr-in 3.229 HRD-in -77.06, -45.91 77.83, -23.23 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -92.44, 115.48 APE9-dihe-na -69.73, -64.71 APE8-dihe-in -105.78, 124.29 APE8-rot-in 283.0 APE67-dihe-in -50.65, -45.32 -72.98, -15.17 APE12-dist-in 7.382 APE11-dist-in 10.194 APE10-dist-out 9.123 APE9-dist-out 9.352 None None None XRAY 2.286 0.188 0.236 D 410 397 0 0 0 0 [[76, 338]] 1.0 3v8s AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PA Q13464 6 405 1354.0 3J7:501 Type1 Active DFGin 6.259 12.978 BLAminus DFGAsp-rot-in -131.32, -179.69 55.02, 77.47 198.76, 11.12 -91.49, 17.42 302.12, 101.71 -69.96, -11.88 in-in in 8.182 Saltbr-in 2.566 HRD-in -62.73, -47.54 67.38, -1.52 in-in-in SNCiii in-in ActLoopNT-in 3.077 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.79, 138.22 APE9-dihe-na 110.79, -174.17 APE8-dihe-in -93.29, 129.06 APE8-rot-in 302.8 APE67-dihe-in -74.33, -31.52 -36.7, -38.86 APE12-dist-in 10.731 APE11-dist-in 11.462 APE10-dist-in 5.952 APE9-dist-in 3.674 None None None XRAY 2.8 0.208 0.246 A 411 388 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PB Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.154 13.435 BLAminus DFGAsp-rot-in -133.96, 174.8 56.5, 83.88 178.54, 23.36 -98.36, 33.02 302.17, 98.2 -70.04, -15.43 in-in in 8.214 Saltbr-in 2.726 HRD-in -62.94, -46.77 66.68, -0.73 in-in-in SNCiii in-in ActLoopNT-in 3.094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.83, 139.14 APE9-dihe-na 109.13, -172.67 APE8-dihe-in -92.68, 127.41 APE8-rot-in 302.74 APE67-dihe-in -74.45, -31.78 -35.08, -39.48 APE12-dist-in 10.707 APE11-dist-in 11.408 APE10-dist-in 5.883 APE9-dist-in 3.703 None None None XRAY 2.8 0.208 0.246 B 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PC Q13464 6 401 1354.0 3J7:501 Type1 Active DFGin 6.282 13.256 BLAminus DFGAsp-rot-in -124.31, 179.51 53.21, 87.62 191.44, 20.02 -105.48, 23.02 305.5, 95.5 -67.24, -3.72 in-in in 8.257 Saltbr-in 2.797 HRD-in -62.84, -46.85 67.56, -2.48 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.95, 139.35 APE9-dihe-na 109.16, -174.28 APE8-dihe-in -91.11, 127.59 APE8-rot-in 304.22 APE67-dihe-in -73.68, -32.3 -37.14, -39.74 APE12-dist-in 10.725 APE11-dist-in 11.541 APE10-dist-in 6.024 APE9-dist-in 3.675 None None None XRAY 2.8 0.208 0.246 C 411 383 7 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4W7PD Q13464 6 403 1354.0 3J7:501 Type1 Active DFGin 6.352 13.321 BLAminus DFGAsp-rot-in -140.19, -177.5 56.39, 77.39 190.6, 2.96 -95.5, 16.8 300.98, 99.72 -61.76, -14.51 in-in in 8.291 Saltbr-in 2.836 HRD-in -63.87, -49.18 67.62, 4.17 in-in-in SNCiii in-in ActLoopNT-in 3.098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.12, 138.83 APE9-dihe-na 110.39, -175.06 APE8-dihe-in -91.75, 128.12 APE8-rot-in 303.98 APE67-dihe-in -75.08, -31.43 -35.22, -39.46 APE12-dist-in 10.68 APE11-dist-in 11.483 APE10-dist-in 5.932 APE9-dist-in 3.702 None None None XRAY 2.8 0.208 0.246 D 411 387 6 0 0 0 [[76, 338]] 1.0 4w7p AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7JOUA Q13464 9 402 1354.0 VFS:4000 Type1 Inactive DFGin 5.996 13.339 BLAminus DFGAsp-rot-in -143.11, 174.9 56.51, 84.53 180.17, -1.27 -111.27, 42.13 313.94, 101.63 -66.46, -29.86 in-in in 8.585 Saltbr-in 2.649 HRD-in -50.19, -37.76 57.05, 15.82 in-in-out SNCiio in-out ActLoopNT-in 3.205 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -96.97, 107.53 APE9-dihe-na 156.7, 175.62 APE8-dihe-in -79.94, 144.48 APE8-rot-out 53.34 APE67-dihe-in -106.84, -34.67 -68.39, -2.9 APE12-dist-in 11.152 APE11-dist-in 12.095 APE10-dist-in 6.197 APE9-dist-in 3.941 None None None XRAY 3.318 0.218 0.248 A 413 388 6 0 0 0 [[76, 338]] 1.0 7jou AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ESMA Q13464 6 405 1354.0 M77:60416 Type1 Inactive DFGin 6.105 13.688 BLAminus DFGAsp-rot-out -120.74, 175.27 52.57, 92.93 279.12, 63.19 -113.78, 23.07 302.86, 94.18 -55.5, -15.7 in-in in 8.584 Saltbr-in 2.762 HRD-in -64.55, -47.39 72.73, -12.37 in-in-in SNCiii in-in ActLoopNT-in 3.313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 156.73 APE9-dihe-na 129.25, -151.41 APE8-dihe-in -127.71, 135.99 APE8-rot-in 310.98 APE67-dihe-in -65.34, -28.12 -39.62, -57.01 APE12-dist-in 11.724 APE11-dist-in 11.453 APE10-dist-in 5.777 APE9-dist-in 3.535 None None None XRAY 3.2 0.245 0.269 A 415 400 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ESMB Q13464 6 402 1354.0 M77:60416 Type1 Inactive DFGin 6.061 13.637 BLAminus DFGAsp-rot-out -120.7, -179.63 48.01, 93.78 276.45, 66.78 -115.66, 13.56 300.62, 93.21 -64.59, 23.21 in-in in 8.7 Saltbr-in 2.809 HRD-in -64.68, -48.55 75.56, -17.87 in-in-out SNCiio in-out ActLoopNT-in 3.202 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -120.49, 130.15 APE9-dihe-na -108.34, 137.67 APE8-dihe-out 42.68, 79.42 APE8-rot-out 61.99 APE67-dihe-in -35.68, -40.73 -70.2, -8.79 APE12-dist-in 8.402 APE11-dist-in 12.146 APE10-dist-out 11.118 APE9-dist-out 9.349 None None None XRAY 3.2 0.245 0.269 B 415 397 0 0 0 0 [[76, 338]] 1.0 2esm AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETKA Q13464 6 405 1354.0 HFS:60416 Type1 Active DFGin 6.059 14.097 BLAminus DFGAsp-rot-in -116.57, 151.42 65.52, 106.25 193.08, -22.07 -118.99, 38.28 303.23, 95.7 -62.53, -30.1 in-in in 9.024 Saltbr-in 3.087 HRD-in -67.16, -45.15 69.82, -9.8 in-in-in SNCiii in-in ActLoopNT-in 3.224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.46, 135.93 APE9-dihe-na 138.1, -153.58 APE8-dihe-in -121.49, 133.91 APE8-rot-in 318.16 APE67-dihe-in -78.08, -32.49 -44.0, -39.32 APE12-dist-in 11.84 APE11-dist-in 11.546 APE10-dist-in 5.856 APE9-dist-in 3.737 None None None XRAY 2.96 0.278 0.298 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etk AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETKB Q13464 6 402 1354.0 HFS:60416 Type1 Inactive DFGin 6.099 14.036 BLAminus DFGAsp-rot-in -119.07, 154.83 65.29, 101.07 188.42, 8.65 -117.09, 36.18 302.09, 93.41 -68.48, -4.85 in-in in 9.089 Saltbr-in 3.243 HRD-in -65.95, -45.05 68.6, -11.17 in-in-out SNCiio in-out ActLoopNT-in 3.209 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -71.16, 135.51 APE9-dihe-na -102.49, 125.46 APE8-dihe-out 53.01, 88.66 APE8-rot-out 64.43 APE67-dihe-in -46.44, -46.86 -71.84, 0.84 APE12-dist-in 8.509 APE11-dist-in 12.745 APE10-dist-out 10.626 APE9-dist-out 9.202 None None None XRAY 2.96 0.278 0.298 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etk AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETRA Q13464 6 405 1354.0 Y27:60416 Type1 Active DFGin 6.023 14.033 BLAminus DFGAsp-rot-in -115.35, 151.29 66.22, 120.62 185.79, 11.71 -135.54, 23.8 302.55, 92.69 -59.35, -26.34 in-in in 8.786 Saltbr-in 2.733 HRD-in -66.03, -45.85 73.19, -11.33 in-in-in SNCiii in-in ActLoopNT-in 3.095 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.94, 135.12 APE9-dihe-na 138.18, -155.48 APE8-dihe-in -122.76, 133.42 APE8-rot-in 310.03 APE67-dihe-in -71.74, -29.22 -38.34, -50.83 APE12-dist-in 11.748 APE11-dist-in 11.548 APE10-dist-in 5.877 APE9-dist-in 3.701 None None None XRAY 2.6 0.252 0.266 A 415 400 0 0 0 0 [[76, 338]] 1.0 2etr AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2ETRB Q13464 6 402 1354.0 Y27:60416 Type1 Inactive DFGin 5.864 13.479 BLAminus DFGAsp-rot-in -117.79, 150.58 66.33, 120.21 187.8, 3.44 -134.86, 36.11 306.16, 88.12 -76.52, 0.93 in-in in 8.686 Saltbr-in 2.752 HRD-in -64.78, -48.06 73.52, -11.25 in-in-out SNCiio in-out ActLoopNT-in 3.134 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -133.18, 138.43 APE9-dihe-na -103.78, 137.39 APE8-dihe-out 35.65, 91.86 APE8-rot-out 53.99 APE67-dihe-in -36.65, -43.6 -71.33, -4.49 APE12-dist-in 8.911 APE11-dist-in 12.333 APE10-dist-out 10.993 APE9-dist-out 9.421 None None None XRAY 2.6 0.252 0.266 B 415 397 0 0 0 0 [[76, 338]] 1.0 2etr AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3D9VA Q13464 6 405 1354.0 H52:60416 Type1 Active DFGin 6.202 14.259 BLAminus DFGAsp-rot-in -97.17, 154.71 64.91, 125.89 173.22, 64.61 -137.95, 39.08 298.06, 99.68 -71.65, -6.65 in-in in 9.177 Saltbr-in 3.154 HRD-in -71.72, -45.61 70.74, -5.17 in-in-in SNCiii in-in ActLoopNT-in 3.202 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.18, 131.07 APE9-dihe-na 140.68, -156.12 APE8-dihe-in -114.86, 135.68 APE8-rot-in 311.45 APE67-dihe-in -80.47, -37.33 -48.71, -38.59 APE12-dist-in 11.746 APE11-dist-in 11.776 APE10-dist-in 6.137 APE9-dist-in 3.756 None None None XRAY 3.3 0.262 0.28 A 415 400 0 0 0 0 [[76, 338]] 1.0 3d9v AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3D9VB Q13464 6 402 1354.0 H52:60416 Type1 Inactive DFGin 6.233 14.285 BLAminus DFGAsp-rot-in -106.4, 155.82 65.21, 114.96 180.6, -80.21 -130.45, 38.78 300.73, 91.97 -71.81, 5.36 in-in in 9.284 Saltbr-in 3.361 HRD-in -72.68, -45.11 70.15, -5.49 in-in-out SNCiio in-out ActLoopNT-in 3.348 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -129.14, 113.22 APE9-dihe-na -106.7, 121.13 APE8-dihe-out 49.67, 80.41 APE8-rot-out 65.01 APE67-dihe-in -69.09, -34.75 -74.38, 9.95 APE12-dist-in 8.626 APE11-dist-in 11.99 APE10-dist-out 12.647 APE9-dist-out 8.602 None None None XRAY 3.3 0.262 0.28 B 415 397 0 0 0 0 [[76, 338]] 1.0 3d9v AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVCA Q13464 6 405 1354.0 4KH:60501 Type1 Active DFGin 5.87 13.114 BLAminus DFGAsp-rot-in -131.73, 179.43 49.79, 78.91 196.76, -3.88 -95.58, 35.98 309.76, 96.36 -52.74, -39.15 in-in in 8.425 Saltbr-in 3.027 HRD-in -62.91, -47.72 78.09, -4.27 in-in-in SNCiii in-in ActLoopNT-in 3.063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.16, 137.86 APE9-dihe-na 126.1, -158.78 APE8-dihe-in -106.17, 145.81 APE8-rot-in 290.0 APE67-dihe-in -72.07, -14.66 -55.89, -48.56 APE12-dist-in 11.644 APE11-dist-in 11.414 APE10-dist-in 5.915 APE9-dist-in 3.809 None None None XRAY 3.2 0.193 0.221 A 415 388 5 0 0 0 [[76, 338]] 1.0 4yvc AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVCB Q13464 6 402 1354.0 4KH:60501 Type1 Inactive DFGin 5.987 13.03 BLAminus DFGAsp-rot-in -134.48, 170.05 59.86, 81.37 180.93, 17.05 -101.66, 32.67 304.4, 103.91 -59.54, -31.24 in-in in 8.077 Saltbr-in 2.876 HRD-in -67.8, -48.64 81.06, -11.79 in-in-out SNCiio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -102.76, 137.3 APE9-dihe-na -116.91, 99.15 APE8-dihe-out 69.44, 93.76 APE8-rot-in 303.49 APE67-dihe-in -38.38, -37.91 -75.8, -10.12 APE12-dist-in 8.33 APE11-dist-in 11.844 APE10-dist-out 10.644 APE9-dist-out 9.52 None None None XRAY 3.2 0.193 0.221 B 415 391 0 0 0 0 [[76, 338]] 1.0 4yvc AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVEA Q13464 6 405 1354.0 4KK:60501 Type1 Active DFGin 5.621 12.807 BLAminus DFGAsp-rot-in -135.63, 174.2 57.57, 62.47 168.6, 32.55 -84.06, 54.44 321.53, 81.4 -64.54, -38.78 in-in in 8.392 Saltbr-in 2.839 HRD-in -66.81, -33.75 61.05, -11.49 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.37, 139.44 APE9-dihe-na 133.32, -156.65 APE8-dihe-in -109.47, 141.28 APE8-rot-in 300.76 APE67-dihe-in -87.71, -40.47 -52.3, -33.35 APE12-dist-in 11.916 APE11-dist-in 11.54 APE10-dist-in 6.006 APE9-dist-in 3.84 None None None XRAY 3.4 0.219 0.244 A 415 390 4 0 0 0 [[76, 338]] 1.0 4yve AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 4YVEB Q13464 6 402 1354.0 4KK:60501 Type1 Inactive DFGin 5.949 13.034 BLAminus DFGAsp-rot-in -142.15, 177.6 55.83, 66.0 192.42, -19.73 -91.48, 48.79 310.94, 106.94 -71.74, -55.62 in-in in 8.402 Saltbr-in 2.706 HRD-in -79.37, -42.41 80.29, -49.62 in-in-out SNCiio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iiio APE10-dihe-na -118.45, 127.42 APE9-dihe-na -99.77, 159.7 APE8-dihe-out 61.11, 72.27 APE8-rot-in 329.33 APE67-dihe-in -42.85, -44.14 -72.95, -1.39 APE12-dist-in 8.194 APE11-dist-in 11.937 APE10-dist-in 7.801 APE9-dist-out 10.537 None None None XRAY 3.4 0.219 0.244 B 415 392 0 0 0 0 [[76, 338]] 1.0 4yve AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5BMLA Q13464 6 405 1354.0 4TW:60501 Type1 Active DFGin 6.166 13.115 BLAminus DFGAsp-rot-in -136.45, -178.03 52.19, 80.38 188.51, 26.99 -99.05, 18.0 302.5, 105.79 -59.89, -6.36 in-in in 8.173 Saltbr-in 2.761 HRD-in -66.74, -49.49 70.73, -5.79 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.01, 144.84 APE9-dihe-na 123.64, -151.58 APE8-dihe-in -116.7, 138.56 APE8-rot-in 292.02 APE67-dihe-in -71.41, -43.61 -45.01, -45.51 APE12-dist-in 12.171 APE11-dist-in 11.52 APE10-dist-in 6.047 APE9-dist-in 3.748 None None None XRAY 2.95 0.207 0.235 A 415 393 2 0 0 0 [[76, 338]] 1.0 5bml AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5BMLB Q13464 6 402 1354.0 4TW:60501 Type1 Inactive DFGin 6.168 12.813 BLAminus DFGAsp-rot-in -147.33, 171.63 63.14, 85.86 189.53, 22.55 -106.59, 29.54 304.93, 104.29 -62.75, -25.28 in-in in 8.166 Saltbr-in 3.067 HRD-in -63.43, -48.76 84.09, -44.69 in-in-out SNCiio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -95.23, 140.75 APE9-dihe-na -114.06, 93.2 APE8-dihe-out 74.29, 102.13 APE8-rot-in 315.97 APE67-dihe-in -37.39, -45.07 -85.5, -0.43 APE12-dist-in 8.479 APE11-dist-in 11.901 APE10-dist-out 10.138 APE9-dist-out 10.233 None None None XRAY 2.95 0.207 0.235 B 415 394 0 0 0 0 [[76, 338]] 1.0 5bml AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSA Q13464 6 405 1354.0 6U1:60501 Type1 Active DFGin 6.186 13.352 BLAminus DFGAsp-rot-in -142.64, 177.27 59.6, 62.04 199.21, -31.59 -81.65, 21.26 304.3, 101.28 -54.79, -41.15 in-in in 8.259 Saltbr-in 2.754 HRD-in -54.42, -38.35 63.96, -11.55 in-in-in SNCiii in-in ActLoopNT-in 3.078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.2, 147.03 APE9-dihe-na 120.6, -151.04 APE8-dihe-in -115.4, 140.07 APE8-rot-in 299.71 APE67-dihe-in -59.58, -43.85 -44.15, -59.93 APE12-dist-in 11.887 APE11-dist-in 11.441 APE10-dist-in 5.829 APE9-dist-in 3.748 None None None XRAY 3.3 0.215 0.254 A 415 395 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTA Q13464 6 405 1354.0 6U2:60501 Type1 Active DFGin 6.335 13.585 BLAminus DFGAsp-rot-in -128.59, -176.48 50.52, 79.42 196.8, 0.41 -95.97, 17.69 299.29, 99.89 -62.82, -14.55 in-in in 8.893 Saltbr-in 2.772 HRD-in -67.63, -48.61 71.19, -4.25 in-in-in SNCiii in-in ActLoopNT-in 3.047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, 142.19 APE9-dihe-na 128.21, -142.04 APE8-dihe-in -128.93, 139.4 APE8-rot-in 303.92 APE67-dihe-in -73.59, -33.97 -48.22, -44.35 APE12-dist-in 11.474 APE11-dist-in 11.675 APE10-dist-in 6.173 APE9-dist-in 3.606 None None None XRAY 2.8 0.223 0.237 A 415 389 4 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5UZJA Q13464 6 405 1354.0 8UV:60501 Type1 Active DFGin 6.17 13.101 BLAminus DFGAsp-rot-in -139.82, 174.8 51.53, 74.94 183.89, 17.98 -94.18, 44.21 303.79, 97.11 -58.95, -59.6 in-in in 8.64 Saltbr-in 2.794 HRD-in -71.22, -41.37 70.75, -24.52 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.33, 135.82 APE9-dihe-na 134.09, -159.86 APE8-dihe-in -104.52, 140.59 APE8-rot-in 298.4 APE67-dihe-in -92.6, -25.3 -52.4, -27.33 APE12-dist-in 11.906 APE11-dist-in 11.503 APE10-dist-in 5.992 APE9-dist-in 4.031 None None None XRAY 3.3 0.202 0.241 A 415 387 8 0 0 0 [[76, 338]] 1.0 5uzj AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5UZJB Q13464 6 402 1354.0 8UV:60501 Type1 Inactive DFGin 6.193 13.233 BLAminus DFGAsp-rot-in -141.66, 165.11 62.71, 74.36 182.61, 18.49 -91.14, 38.13 303.19, 107.23 -56.15, -61.3 in-in in 8.556 Saltbr-in 2.669 HRD-in -70.32, -41.49 73.65, -34.67 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.09, 138.52 APE9-dihe-na -78.02, -115.28 APE8-dihe-in -91.0, 118.08 APE8-rot-out 62.39 APE67-dihe-in -38.15, -42.63 -62.29, -19.27 APE12-dist-in 8.509 APE11-dist-in 11.348 APE10-dist-out 10.742 APE9-dist-out 9.849 None None None XRAY 3.3 0.202 0.241 B 415 385 6 0 0 0 [[76, 338]] 1.0 5uzj AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJA Q13464 7 402 1354.0 07R:1 Type1.5_Back Inactive DFGin 5.7 13.165 BLAminus DFGAsp-rot-in -143.98, -170.74 43.72, 70.92 183.08, 5.99 -91.2, 6.87 296.12, 123.32 -47.0, -46.98 in-in in 8.565 Saltbr-in 2.723 HRD-out -68.6, -38.18 61.09, 82.09 in-in-out SNCiio in-out ActLoopNT-in 3.15 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -137.63, -171.58 APE9-dihe-na -153.4, 162.36 APE8-dihe-out 59.85, 72.82 APE8-rot-in 311.01 APE67-dihe-in -44.17, -44.94 -71.0, -20.06 APE12-dist-in 7.743 APE11-dist-in 11.217 APE10-dist-out 8.638 APE9-dist-out 9.812 None None None XRAY 2.9 0.224 0.289 A 410 396 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUA Q13464 6 405 1354.0 65R:60501 Type1.5_Front Active DFGin 6.064 13.008 BLAminus DFGAsp-rot-in -144.77, -177.33 55.22, 80.15 194.27, 8.27 -106.17, 33.13 305.29, 103.88 -64.0, -11.53 in-in in 8.403 Saltbr-in 2.919 HRD-in -68.11, -52.8 76.77, -16.02 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.34, 135.58 APE9-dihe-na 137.6, -151.11 APE8-dihe-in -124.0, 136.06 APE8-rot-in 298.85 APE67-dihe-in -72.28, -36.35 -46.39, -41.26 APE12-dist-in 12.022 APE11-dist-in 11.468 APE10-dist-in 5.929 APE9-dist-in 3.886 None None None XRAY 2.8 0.239 0.248 A 415 394 0 0 0 0 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5HVUB Q13464 6 402 1354.0 65R:60501 Type1.5_Front Inactive DFGin 6.027 12.975 BLAminus DFGAsp-rot-in -150.94, 172.97 62.5, 81.89 189.92, 10.32 -105.96, 31.62 305.32, 102.48 -65.13, -10.17 in-in in 8.313 Saltbr-in 2.938 HRD-in -68.69, -52.17 76.83, -16.13 in-in-out SNCiio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.5 APE8-rot-out 85.32 APE67-dihe-in -36.29, -45.18 -89.86, -8.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.239 0.248 B 415 393 4 0 0 4 [[76, 338]] 1.0 5hvu AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKSB Q13464 6 402 1354.0 6U1:60501 Type1.5_Front Inactive DFGin 6.14 13.336 BLAminus DFGAsp-rot-in -142.66, 177.11 58.73, 60.85 198.24, -30.27 -80.32, 21.73 304.44, 101.0 -56.11, -39.34 in-in in 8.227 Saltbr-in 2.746 HRD-in -68.72, -42.28 78.49, -44.71 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -104.48, 133.16 APE9-dihe-na -95.73, 130.38 APE8-dihe-out 63.66, 89.81 APE8-rot-out 67.34 APE67-dihe-in -44.41, -53.62 -78.83, 5.04 APE12-dist-in 8.715 APE11-dist-in 12.174 APE10-dist-out 8.649 APE9-dist-out 10.213 None None None XRAY 3.3 0.215 0.254 B 415 394 0 0 0 0 [[76, 338]] 1.0 5kks AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5KKTB Q13464 6 402 1354.0 6U2:60501 Type1.5_Front Inactive DFGin 6.306 13.599 BLAminus DFGAsp-rot-in -130.02, -177.11 50.1, 80.15 197.72, -0.81 -95.96, 18.23 299.48, 98.02 -62.02, -10.47 in-in in 8.889 Saltbr-in 2.78 HRD-in -68.38, -47.41 71.48, -14.73 in-in-out SNCiio in-out ActLoopNT-in 3.073 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -110.61, 86.79 APE9-dihe-na -63.17, 97.09 APE8-dihe-out 74.12, 110.85 APE8-rot-in 316.95 APE67-dihe-in -53.36, -37.05 -91.57, 10.0 APE12-dist-in 8.432 APE11-dist-in 11.357 APE10-dist-out 10.199 APE9-dist-out 9.422 None None None XRAY 2.8 0.223 0.237 B 415 393 0 0 0 0 [[76, 338]] 1.0 5kkt AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEA Q13464 14 400 1354.0 B4J:60501 Type1.5_Front Active DFGin 6.225 13.567 BLAminus DFGAsp-rot-in -135.0, 175.35 53.04, 84.77 186.88, 58.35 -102.97, 28.35 302.63, 101.99 -70.63, -10.88 in-in in 8.951 Saltbr-in 2.812 HRD-in -65.73, -50.65 71.21, -5.22 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.88, 137.37 APE9-dihe-na 126.73, -152.59 APE8-dihe-in -112.81, 138.1 APE8-rot-in 304.24 APE67-dihe-in -78.8, -30.66 -52.66, -36.48 APE12-dist-in 10.985 APE11-dist-in 11.543 APE10-dist-in 5.882 APE9-dist-in 3.725 None None None XRAY 2.6 0.229 0.246 A 415 384 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus DFGAsp-rot-in -143.39, 177.51 52.52, 73.92 190.34, 63.29 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEC Q13464 6 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.226 13.312 BLAminus DFGAsp-rot-in -141.6, 173.01 60.67, 84.57 201.57, -2.47 -108.59, 26.04 304.33, 107.59 -71.96, -9.2 in-in in 8.556 Saltbr-in 2.815 HRD-in -53.88, -50.49 68.34, -4.44 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 131.39 APE9-dihe-na 141.47, -150.22 APE8-dihe-in -114.01, 135.26 APE8-rot-in 304.1 APE67-dihe-in -79.17, -28.35 -50.74, -38.29 APE12-dist-in 10.779 APE11-dist-in 11.589 APE10-dist-in 5.735 APE9-dist-in 3.822 None None None XRAY 2.6 0.229 0.246 C 415 382 9 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNED Q13464 7 402 1354.0 B4J:60900 Type1.5_Front Active DFGin 6.109 13.38 BLAminus DFGAsp-rot-in -136.38, 179.68 48.06, 76.76 196.48, 0.38 -93.24, 35.49 302.92, 95.86 -65.45, -20.45 in-in in 8.487 Saltbr-in 2.785 HRD-in -58.19, -50.71 67.27, -4.18 in-in-in SNCiii in-in ActLoopNT-in 3.222 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.61, 140.56 APE9-dihe-na 127.23, -150.56 APE8-dihe-in -113.66, 136.6 APE8-rot-in 304.03 APE67-dihe-in -77.29, -31.2 -52.52, -36.89 APE12-dist-in 10.389 APE11-dist-in 11.435 APE10-dist-in 5.778 APE9-dist-in 3.834 None None None XRAY 2.6 0.229 0.246 D 415 396 0 0 0 0 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26C Q13464 8 402 1354.0 86K:60501 Type1 Inactive DFGin 5.95 13.37 BLBminus DFGAsp-rot-in -142.33, 179.72 55.18, 85.73 181.0, 9.18 -101.52, 145.33 303.83, 102.55 -56.13, 999.0 in-in in 8.639 Saltbr-in 2.744 HRD-in -63.89, -36.06 71.41, -31.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 145.87 APE8-rot-out 190.89 APE67-dihe-in -62.24, -33.76 -58.59, -27.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 C 398 363 18 0 0 18 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJC Q13464 7 402 1354.0 07R:2 Type1 Inactive DFGin 8.759 16.273 None DFGAsp-rot-in -145.99, 165.67 60.97, 69.02 217.61, 54.97 -57.54, -10.47 212.34, 59.8 -68.93, 18.62 in-out in 7.794 Saltbr-out 3.822 HRD-in -73.44, -64.4 76.54, -16.94 out-out-out SNCooo out-out ActLoopNT-out 3.649 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oiio APE10-dihe-na -174.55, 155.89 APE9-dihe-na -163.77, 151.18 APE8-dihe-out 67.81, 65.3 APE8-rot-in 318.87 APE67-dihe-in -61.73, -42.12 -68.66, -9.31 APE12-dist-out 6.763 APE11-dist-in 8.218 APE10-dist-in 6.246 APE9-dist-out 9.049 None None None XRAY 2.9 0.224 0.289 C 410 396 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJB Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.815 7.295 None DFGAsp-rot-in -140.02, 177.72 -138.03, 117.9 222.7, -23.05 -134.18, -179.7 267.51, 14.98 -75.11, 143.68 in-in in 8.042 Saltbr-in 3.562 HRD-in -70.23, -44.84 80.45, -14.54 in-out-out SNCioo out-out ActLoopNT-out 20.375 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.17, 145.08 APE9-dihe-na 57.93, -141.29 APE8-dihe-in -142.15, 148.38 APE8-rot-out 101.8 APE67-dihe-in -61.61, -39.57 -51.91, -51.11 APE12-dist-in 11.787 APE11-dist-in 13.034 APE10-dist-out 12.316 APE9-dist-in 4.196 None None None XRAY 2.9 0.224 0.289 B 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJD Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.79 6.927 None DFGAsp-rot-in -126.16, 176.03 -134.68, 123.87 202.81, -39.78 -143.34, -165.47 284.96, 15.3 -95.64, -168.75 in-in in 8.257 Saltbr-in 2.943 HRD-in -49.62, -47.32 79.16, -22.55 in-out-out SNCioo out-out ActLoopNT-out 20.397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na 45.48, 65.51 APE9-dihe-na 78.31, -176.86 APE8-dihe-in -88.74, 143.63 APE8-rot-out 17.15 APE67-dihe-in -61.11, -33.54 -55.29, -47.59 APE12-dist-in 9.993 APE11-dist-in 10.777 APE10-dist-out 10.945 APE9-dist-in 5.297 None None None XRAY 2.9 0.224 0.289 D 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25A Q13464 7 401 1354.0 86G:504 Type1 Inactive DFGout 12.318 10.54 None DFGAsp-rot-in -104.78, 156.55 -123.71, 119.26 176.34, -77.89 -167.75, -177.1 52.05, 88.34 -122.16, 999.0 in-in in 8.453 Saltbr-in 2.76 HRD-in -48.48, -35.86 65.44, -17.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.37 APE8-dihe-in -84.85, 138.74 APE8-rot-in 343.84 APE67-dihe-in -53.73, -33.25 -65.56, -53.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.105 None None None XRAY 2.337 0.24 0.271 A 396 373 22 0 0 17 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25B Q13464 8 402 1354.0 86G:501 Type1 Inactive DFGout 12.161 10.144 None DFGAsp-rot-in -102.96, 170.2 -133.51, 102.53 185.55, 30.67 -164.51, 160.19 55.37, 93.46 -104.18, 142.28 in-in in 8.647 Saltbr-in 2.71 HRD-in -64.3, -54.36 69.65, -10.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -102.96, -6.09 APE9-dihe-na 73.94, -123.45 APE8-dihe-in -79.15, 120.74 APE8-rot-in 312.82 APE67-dihe-in -46.47, -33.29 -85.89, -15.42 APE12-dist-in 11.32 APE11-dist-in 11.306 APE10-dist-out 9.412 APE9-dist-out 8.405 None None None XRAY 2.337 0.24 0.271 B 396 379 12 0 0 12 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25C Q13464 13 402 1354.0 86G:501 Type1 Inactive DFGout 12.693 10.544 None DFGAsp-rot-in -104.89, 170.47 -133.65, 98.69 186.04, 28.13 -152.01, 158.42 54.9, 83.0 -75.12, 999.0 in-in in 8.505 Saltbr-in 2.799 HRD-in -63.41, -47.95 72.04, -26.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 89.67 APE8-rot-out 72.08 APE67-dihe-in -54.43, -34.25 -48.72, -39.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 C 396 361 18 0 0 18 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25D Q13464 9 401 1354.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -105.32, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.472 Saltbr-in 2.733 HRD-in -82.09, -47.81 61.94, 11.48 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.337 0.24 0.271 D 396 257 113 0 0 29 [[76, 338]] 1.0 7s25 AGC_ROCK1_HUMAN AGC 3.1e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 6P5MC O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.284 13.921 ABAminus DFGAsp-rot-in -122.7, -9.78 -139.64, 138.02 188.37, -54.23 -140.63, 30.64 305.79, 99.12 -60.86, -31.72 in-in in 9.232 Saltbr-in 2.912 HRD-in -79.08, -59.4 80.67, -6.5 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 160.25 APE9-dihe-na 91.47, 176.97 APE8-dihe-in -75.63, 130.45 APE8-rot-in 321.11 APE67-dihe-in -50.51, -34.84 -49.48, -49.9 APE12-dist-in 9.739 APE11-dist-in 11.525 APE10-dist-in 5.487 APE9-dist-in 3.9 F270Y None None XRAY 2.65 0.195 0.225 C 405 395 0 0 0 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5MD O75116 18 417 1388.0 No_ligand No_ligand Inactive DFGin 6.285 13.936 ABAminus DFGAsp-rot-in -122.32, -12.13 -136.93, 137.32 185.34, -53.31 -138.61, 32.6 305.2, 99.15 -64.64, -30.48 in-in in 9.204 Saltbr-in 2.902 HRD-in -80.83, -60.28 80.37, -5.42 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.85, 159.37 APE9-dihe-na 92.74, 176.75 APE8-dihe-in -76.16, 130.74 APE8-rot-in 321.06 APE67-dihe-in -51.46, -34.25 -48.82, -49.31 APE12-dist-in 9.478 APE11-dist-in 11.322 APE10-dist-in 5.295 APE9-dist-in 3.91 F270Y None None XRAY 2.65 0.195 0.225 D 405 395 0 0 0 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7QA O75116 25 417 1388.0 No_ligand No_ligand Inactive DFGin 6.259 13.944 ABAminus DFGAsp-rot-in -118.38, -30.33 -115.44, 138.21 196.25, -39.88 -136.2, 22.48 302.79, 98.72 -67.44, -9.24 in-in in 9.345 Saltbr-in 2.851 HRD-in -71.59, -51.25 68.38, 10.85 in-in-out SNCiio in-out ActLoopNT-in 3.053 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.07, 165.16 APE9-dihe-na 99.44, -174.88 APE8-dihe-in -110.13, 133.98 APE8-rot-out 71.35 APE67-dihe-in -43.56, -39.21 -47.25, -61.0 APE12-dist-in 10.306 APE11-dist-in 11.519 APE10-dist-in 5.823 APE9-dist-in 3.596 None None None XRAY 3.15 0.206 0.235 A 395 388 0 0 0 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7QB O75116 28 417 1388.0 No_ligand No_ligand Inactive DFGin 6.258 13.838 ABAminus DFGAsp-rot-in -117.94, -31.05 -114.29, 137.07 195.7, -39.05 -135.84, 23.64 304.14, 98.35 -71.27, -7.96 in-in in 9.202 Saltbr-in 2.804 HRD-in -69.76, -50.21 70.12, 10.28 in-in-out SNCiio in-out ActLoopNT-in 3.084 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -101.5, 136.43 APE9-dihe-na -97.06, -173.07 APE8-dihe-out 0.71, 109.2 APE8-rot-out 79.45 APE67-dihe-in -42.62, -39.27 -78.6, -9.02 APE12-dist-out 6.323 APE11-dist-in 9.744 APE10-dist-out 9.573 APE9-dist-out 9.45 None None None XRAY 3.15 0.206 0.235 B 395 385 0 0 0 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7QC O75116 23 417 1388.0 No_ligand No_ligand Inactive DFGin 6.24 13.949 ABAminus DFGAsp-rot-in -118.61, -31.03 -114.56, 138.0 196.79, -40.56 -135.58, 22.3 302.64, 98.81 -68.71, -8.98 in-in in 9.306 Saltbr-in 2.846 HRD-in -71.74, -50.43 70.98, 8.22 in-in-out SNCiio in-out ActLoopNT-in 3.065 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.91, 164.09 APE9-dihe-na 99.24, -172.98 APE8-dihe-in -112.36, 135.32 APE8-rot-out 71.33 APE67-dihe-in -43.59, -38.66 -47.45, -62.01 APE12-dist-in 10.361 APE11-dist-in 11.584 APE10-dist-in 5.857 APE9-dist-in 3.591 None None None XRAY 3.15 0.206 0.235 C 395 390 0 0 0 0 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7QD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGin 6.268 13.87 ABAminus DFGAsp-rot-in -117.71, -31.1 -114.96, 137.38 195.65, -38.06 -136.24, 22.53 303.71, 99.02 -69.56, -9.33 in-in in 9.253 Saltbr-in 2.817 HRD-in -70.86, -50.66 64.9, 13.18 in-in-out SNCiio in-out ActLoopNT-in 3.07 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iiio APE10-dihe-na 129.84, 128.46 APE9-dihe-na 155.49, 162.77 APE8-dihe-in -98.68, 133.35 APE8-rot-out 69.96 APE67-dihe-out 26.46, -59.82 -69.88, -74.55 APE12-dist-in 10.259 APE11-dist-in 9.248 APE10-dist-in 6.569 APE9-dist-out 7.754 None None None XRAY 3.15 0.206 0.235 D 395 383 3 0 0 3 [[92, 354]] 1.0 5u7q AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7RA O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 6.021 13.393 ABAminus DFGAsp-rot-in -124.59, -51.34 -100.7, 98.55 200.24, -38.11 -98.24, 10.15 301.55, 107.52 -53.67, -30.47 in-in in 8.88 Saltbr-in 2.674 HRD-in -86.61, -51.16 76.24, -9.42 in-in-out SNCiio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -101.07, 144.01 APE9-dihe-na 118.28, 178.92 APE8-dihe-in -78.19, 127.98 APE8-rot-out 37.97 APE67-dihe-in -75.92, -25.7 -48.83, -32.29 APE12-dist-in 10.032 APE11-dist-in 11.648 APE10-dist-in 5.657 APE9-dist-in 4.152 None None None XRAY 3.33 0.202 0.241 A 395 387 0 0 0 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7RC O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.939 13.56 ABAminus DFGAsp-rot-in -130.76, -53.46 -102.99, 94.4 205.89, -36.41 -95.45, 17.91 300.98, 105.74 -67.72, -17.68 in-in in 8.525 Saltbr-in 2.875 HRD-in -81.89, -48.76 85.63, -53.94 in-in-out SNCiio in-out ActLoopNT-in 3.142 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -119.26, 144.44 APE9-dihe-na -73.26, -103.48 APE8-dihe-in -77.65, 129.34 APE8-rot-out 33.83 APE67-dihe-in -30.2, -56.76 -78.66, -11.76 APE12-dist-out 6.043 APE11-dist-in 9.425 APE10-dist-in 7.667 APE9-dist-out 9.933 None None None XRAY 3.33 0.202 0.241 C 395 387 0 0 0 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5PA O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.1 13.798 ABAminus DFGAsp-rot-in -140.54, -38.15 -103.07, 135.03 199.7, -37.0 -138.91, 13.89 292.53, 107.02 -62.06, -18.82 in-in in 9.044 Saltbr-in 2.705 HRD-in -91.96, -54.28 90.29, -35.29 in-in-out SNCiio in-out ActLoopNT-in 3.098 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.88, 157.67 APE9-dihe-na 95.31, 171.85 APE8-dihe-in -89.1, 136.7 APE8-rot-out 43.44 APE67-dihe-in -58.47, -37.34 -54.83, -41.99 APE12-dist-in 9.854 APE11-dist-in 11.647 APE10-dist-in 5.642 APE9-dist-in 4.505 F270Y None None XRAY 3.3 0.207 0.236 A 405 386 0 0 0 0 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5PB O75116 27 417 1388.0 O1V:2500 Type1 Inactive DFGin 6.09 13.667 ABAminus DFGAsp-rot-in -142.64, -37.41 -103.44, 133.69 201.76, -39.58 -139.28, 14.63 293.57, 107.2 -60.04, -21.17 in-in in 8.717 Saltbr-in 2.713 HRD-in -86.41, -51.75 93.44, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.115 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, 98.93 APE9-dihe-na 96.49, 160.02 APE8-dihe-out -136.03, -48.15 APE8-rot-out 58.37 APE67-dihe-out -95.66, -8.92 -10.89, 163.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.843 APE9-dist-out 7.785 F270Y None None XRAY 3.3 0.207 0.236 B 405 369 11 0 0 5 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5PC O75116 28 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.059 13.779 ABAminus DFGAsp-rot-in -141.44, -37.71 -103.72, 135.03 199.57, -37.09 -139.29, 13.77 292.2, 107.44 -61.16, -19.58 in-in in 9.02 Saltbr-in 2.584 HRD-in -89.59, -53.69 91.0, -37.17 in-in-out SNCiio in-out ActLoopNT-in 3.097 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.85, 160.08 APE9-dihe-na 94.19, 175.02 APE8-dihe-in -83.56, 138.16 APE8-rot-out 27.44 APE67-dihe-in -59.59, -38.55 -52.39, -43.92 APE12-dist-in 9.868 APE11-dist-in 11.697 APE10-dist-in 5.699 APE9-dist-in 4.614 F270Y None None XRAY 3.3 0.207 0.236 C 405 375 9 0 0 0 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5PD O75116 26 416 1388.0 O1V:2500 Type1 Inactive DFGin 6.063 13.538 ABAminus DFGAsp-rot-in -142.31, -37.19 -102.73, 133.81 201.88, -43.07 -138.95, 14.8 293.03, 107.98 -61.89, -20.52 in-in in 8.729 Saltbr-in 3.003 HRD-in -87.78, -50.98 94.3, -44.63 in-in-out SNCiio in-out ActLoopNT-in 3.105 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na 142.21, 160.44 APE9-dihe-na 98.4, 160.87 APE8-dihe-in -91.67, 134.46 APE8-rot-out 44.39 APE67-dihe-in -35.6, -42.17 -54.98, -42.29 APE12-dist-in 8.54 APE11-dist-in 10.233 APE10-dist-in 6.865 APE9-dist-out 8.1 F270Y None None XRAY 3.3 0.207 0.236 D 405 382 4 0 0 1 [[92, 354]] 1.0 6p5p AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8YB O75116 29 417 1388.0 YEA:501 Type1 Inactive DFGin 6.145 13.096 ABAminus DFGAsp-rot-in -143.12, -33.94 -106.09, 93.06 184.42, 6.25 -90.35, 19.08 311.7, 96.3 -43.48, -33.82 in-in in 8.274 Saltbr-in 2.703 HRD-out -97.55, 96.59 -73.9, -11.34 in-in-out SNCiio in-out ActLoopNT-in 2.676 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -120.75, 154.61 APE9-dihe-na -77.81, -131.7 APE8-dihe-in -64.67, 142.4 APE8-rot-in 325.66 APE67-dihe-in -41.68, -27.46 -83.12, -16.83 APE12-dist-in 7.474 APE11-dist-in 8.067 APE10-dist-in 6.624 APE9-dist-out 9.586 None None None XRAY 3.2 0.185 0.243 B 391 381 2 0 0 2 [[92, 354]] 1.0 8x8y AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8ZA O75116 31 416 1388.0 YEI:501 Type1 Inactive DFGin 6.223 13.322 ABAminus DFGAsp-rot-in -137.94, -35.4 -107.28, 98.66 173.76, 11.98 -104.78, 35.55 309.08, 94.51 -70.09, -34.82 in-in in 8.625 Saltbr-in 2.514 HRD-in -74.7, -54.55 74.9, -7.49 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.04, 159.96 APE9-dihe-na 107.67, -142.65 APE8-dihe-in -117.59, 137.7 APE8-rot-in 304.03 APE67-dihe-in -63.05, -29.24 -60.27, -42.21 APE12-dist-in 9.948 APE11-dist-in 11.454 APE10-dist-in 5.569 APE9-dist-in 3.942 None None None XRAY 2.7 0.202 0.255 A 391 379 0 0 0 0 [[92, 354]] 1.0 8x8z AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8ZB O75116 29 417 1388.0 YEI:501 Type1 Inactive DFGin 6.198 13.072 ABAminus DFGAsp-rot-in -136.69, -32.87 -113.62, 107.48 164.16, 13.74 -108.59, 37.17 307.49, 93.35 -67.13, -33.87 in-in in 8.47 Saltbr-in 3.212 HRD-in -75.89, -53.13 77.36, -18.94 in-in-out SNCiio in-out ActLoopNT-in 3.103 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiio APE10-dihe-na -120.39, 156.94 APE9-dihe-na -95.08, -124.51 APE8-dihe-in -71.89, 132.74 APE8-rot-in 281.12 APE67-dihe-in -52.91, -35.61 -79.81, -3.34 APE12-dist-out 6.223 APE11-dist-in 8.116 APE10-dist-in 6.396 APE9-dist-out 9.068 None None None XRAY 2.7 0.202 0.255 B 391 376 7 0 0 7 [[92, 354]] 1.0 8x8z AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X92A O75116 29 416 1388.0 YEW:501 Type1 Inactive DFGin 6.283 13.509 ABAminus DFGAsp-rot-in -130.17, -37.88 -106.77, 98.05 172.68, 18.53 -102.95, 26.89 303.41, 99.6 -63.14, -27.04 in-in in 8.505 Saltbr-in 2.344 HRD-in -76.14, -56.17 76.65, -10.0 in-in-in SNCiii in-in ActLoopNT-in 3.096 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.17, 164.81 APE9-dihe-na 100.98, -149.71 APE8-dihe-in -115.92, 137.43 APE8-rot-in 295.58 APE67-dihe-in -63.22, -26.51 -58.54, -42.75 APE12-dist-in 10.155 APE11-dist-in 11.523 APE10-dist-in 5.681 APE9-dist-in 3.757 None None None XRAY 2.2 0.209 0.24 A 391 384 0 0 0 0 [[92, 354]] 1.0 8x92 AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X92B O75116 29 417 1388.0 YEW:501 Type1 Inactive DFGin 6.39 13.351 ABAminus DFGAsp-rot-in -130.25, -35.39 -108.15, 104.62 182.37, -2.97 -106.39, 29.3 307.45, 100.77 -61.59, -28.54 in-in in 8.347 Saltbr-in 2.94 HRD-in -76.68, -52.79 78.59, -25.26 in-in-out SNCiio in-out ActLoopNT-in 3.091 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_noio APE10-dihe-na -131.54, -42.51 APE9-dihe-na 102.33, -143.39 APE8-dihe-in -75.11, 133.17 APE8-rot-out 81.17 APE67-dihe-in -53.78, -31.77 -93.71, 6.6 APE12-dist-none 999.0 APE11-dist-out 7.675 APE10-dist-in 6.569 APE9-dist-out 9.536 None None None XRAY 2.2 0.209 0.24 B 391 368 15 0 0 10 [[92, 354]] 1.0 8x92 AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4WOTA O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.194 13.074 ABAminus DFGAsp-rot-in -135.17, -10.51 -134.2, 128.83 180.83, 37.4 -131.16, 28.81 310.32, 108.74 -62.4, -34.78 in-in in 8.967 Saltbr-in 2.447 HRD-in -67.9, -48.5 51.03, 22.17 in-in-out SNCiio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 151.53 APE9-dihe-na 148.47, -177.25 APE8-dihe-in -79.02, 124.53 APE8-rot-out 69.87 APE67-dihe-in -33.84, -49.13 -87.01, 2.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.558 APE9-dist-out 7.983 None None None XRAY 2.93 0.223 0.268 A 396 389 3 0 0 3 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4WOTB O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.206 13.412 ABAminus DFGAsp-rot-in -121.15, -29.83 -129.18, 101.54 177.58, 42.03 -100.78, 25.44 307.28, 101.28 -60.27, -29.91 in-in in 9.239 Saltbr-in 2.555 HRD-in -73.23, -53.38 48.65, 30.57 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.19, 136.46 APE9-dihe-na 130.7, 169.23 APE8-dihe-in -78.33, 140.31 APE8-rot-in 315.87 APE67-dihe-in -66.72, -32.79 -54.96, -39.47 APE12-dist-in 10.27 APE11-dist-in 11.121 APE10-dist-in 5.401 APE9-dist-in 3.961 None None None XRAY 2.93 0.223 0.268 B 396 394 0 0 0 0 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4WOTC O75116 22 417 1388.0 3SG:501 Type1 Inactive DFGin 6.397 13.136 ABAminus DFGAsp-rot-in -155.48, 37.05 -162.57, 126.3 176.13, 20.78 -126.94, 37.81 307.24, 97.39 -72.68, -39.98 in-in in 8.853 Saltbr-in 2.703 HRD-in -72.02, -52.38 47.81, 35.39 in-in-in SNCiii in-in ActLoopNT-in 3.057 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.22, 153.14 APE9-dihe-na 111.79, 170.52 APE8-dihe-in -74.42, 135.59 APE8-rot-in 311.52 APE67-dihe-in -64.13, -31.94 -46.85, -44.87 APE12-dist-in 10.365 APE11-dist-in 11.172 APE10-dist-in 5.508 APE9-dist-in 4.183 None None None XRAY 2.93 0.223 0.268 C 396 392 0 0 0 0 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4WOTD O75116 23 417 1388.0 3SG:501 Type1 Inactive DFGin 6.252 13.257 ABAminus DFGAsp-rot-in -118.96, -34.54 -121.89, 101.62 181.05, 25.35 -103.9, 33.36 309.85, 95.26 -70.03, -28.11 in-in in 9.087 Saltbr-in 2.443 HRD-in -70.37, -47.18 69.99, 3.47 in-in-out SNCiio in-out ActLoopNT-in 2.93 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -161.47, 159.03 APE9-dihe-na 169.18, 177.89 APE8-dihe-in -96.13, 131.57 APE8-rot-out 64.42 APE67-dihe-in -46.94, -47.22 -87.02, 3.22 APE12-dist-none 999.0 APE11-dist-out 7.565 APE10-dist-out 8.72 APE9-dist-out 7.947 None None None XRAY 2.93 0.223 0.268 D 396 389 2 0 0 2 [[92, 354]] 1.0 4wot AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9HFPA O75116 23 417 1388.0 A1IUI:501 Type1 Inactive DFGin 6.325 13.486 ABAminus DFGAsp-rot-in -116.81, -23.83 -103.61, 131.6 213.38, -55.51 -131.15, 17.95 300.42, 103.4 -50.91, -44.1 in-in in 8.775 Saltbr-in 2.973 HRD-in -60.74, -61.14 76.47, -4.94 in-in-in SNCiii in-in ActLoopNT-in 3.045 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.76, 160.47 APE9-dihe-na 106.89, -168.78 APE8-dihe-in -100.64, 133.74 APE8-rot-in 307.74 APE67-dihe-in -64.45, -23.8 -40.67, -47.85 APE12-dist-in 10.233 APE11-dist-in 11.354 APE10-dist-in 5.491 APE9-dist-in 3.677 None None None XRAY 2.92 0.206 0.22 A 396 391 0 0 0 0 [[92, 354]] 1.0 9hfp AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4L6QA O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.303 13.57 ABAminus DFGAsp-rot-in -116.27, -49.25 -107.45, 128.66 176.6, -6.17 -126.56, 33.88 304.03, 88.55 -72.5, -17.13 in-in in 8.882 Saltbr-in 2.672 HRD-in -73.76, -46.68 73.56, -20.06 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.31, 131.57 APE9-dihe-na 145.53, -153.1 APE8-dihe-in -136.66, 121.88 APE8-rot-out 181.69 APE67-dihe-in -54.43, -25.79 -36.79, -58.64 APE12-dist-in 10.628 APE11-dist-in 11.473 APE10-dist-in 5.696 APE9-dist-in 3.917 None None None XRAY 2.79 0.224 0.281 A 402 388 0 0 0 0 [[92, 354]] 1.0 4l6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 4L6QB O75116 27 417 1388.0 1WU:501 Type1 Inactive DFGin 6.241 13.421 ABAminus DFGAsp-rot-in -107.91, -62.87 -88.93, 144.15 185.6, -8.53 -141.39, 24.98 298.39, 99.37 -69.99, -11.39 in-out in 8.79 Saltbr-out 4.215 HRD-in -77.55, -55.12 77.74, -6.89 out-in-in SNCoii in-in ActLoopNT-in 3.174 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.98, 112.76 APE9-dihe-na 161.13, -165.93 APE8-dihe-in -114.84, 120.25 APE8-rot-in 312.46 APE67-dihe-in -62.07, -22.46 -26.22, -64.13 APE12-dist-in 10.217 APE11-dist-in 11.444 APE10-dist-in 5.753 APE9-dist-in 3.745 None None None XRAY 2.79 0.224 0.281 B 402 388 0 0 0 0 [[92, 354]] 1.0 4l6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN AF-O75116-K1A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.869 12.915 BLAminus DFGAsp-rot-in -136.99, 177.96 53.48, 73.71 201.61, 26.61 -86.19, 14.62 307.2, 104.5 -65.86, -9.9 in-in in 8.731 Saltbr-in 2.651 HRD-in -85.23, -49.89 67.76, 1.46 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 135.21 APE9-dihe-na 135.69, 171.46 APE8-dihe-in -70.75, 130.03 APE8-rot-in 300.74 APE67-dihe-in -77.08, -19.45 -51.29, -40.8 APE12-dist-in 10.485 APE11-dist-in 11.568 APE10-dist-in 5.755 APE9-dist-in 3.634 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[92, 354]] 1.0 AF-O75116-K1 AGC_ROCK2_HUMAN AGC 7.1e-94 319.7 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN AF-O75116-K3A O75116 84 362 1388.0 No_ligand No_ligand Active DFGin 5.82 13.449 BLAminus DFGAsp-rot-in -136.65, 179.19 54.41, 68.61 204.25, 7.76 -80.36, 13.1 307.71, 103.33 -65.49, -10.01 in-in in 8.674 Saltbr-in 2.629 HRD-in -85.92, -46.0 66.47, 0.5 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.35, 142.1 APE9-dihe-na 129.39, 171.44 APE8-dihe-in -69.98, 129.02 APE8-rot-in 286.32 APE67-dihe-in -70.68, -17.36 -43.25, -51.09 APE12-dist-in 10.635 APE11-dist-in 11.941 APE10-dist-in 6.01 APE9-dist-in 3.263 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[92, 354]] 1.0 AF-O75116-K3 AGC_ROCK2_HUMAN AGC 7.1e-94 319.7 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7RB O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.755 13.641 BLAminus DFGAsp-rot-in -141.67, 175.83 55.92, 92.76 185.07, 76.99 -111.9, 4.36 301.65, 97.85 -69.51, 58.89 in-in in 8.85 Saltbr-in 2.559 HRD-in -72.3, -58.92 77.62, -4.98 in-in-out SNCiio in-out ActLoopNT-in 3.049 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.98, 141.69 APE9-dihe-na 134.81, 151.0 APE8-dihe-in -74.28, 133.5 APE8-rot-out 61.19 APE67-dihe-in -51.66, -36.53 -38.48, -66.38 APE12-dist-in 9.905 APE11-dist-in 11.818 APE10-dist-in 5.776 APE9-dist-in 3.643 None None None XRAY 3.33 0.202 0.241 B 395 387 0 0 0 0 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5MA O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.263 13.475 BLAminus DFGAsp-rot-in -124.02, 171.64 60.38, 93.51 206.44, -29.26 -113.45, 31.35 303.9, 98.44 -64.25, -25.91 in-in in 8.495 Saltbr-in 2.834 HRD-in -79.85, -57.22 94.02, -30.37 in-in-out SNCiio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -116.08, 168.2 APE9-dihe-na -93.6, -119.04 APE8-dihe-in -73.92, 129.61 APE8-rot-in 321.09 APE67-dihe-in -55.49, -37.68 -79.71, 0.19 APE12-dist-in 7.801 APE11-dist-in 9.502 APE10-dist-in 7.389 APE9-dist-out 8.943 F270Y None None XRAY 2.65 0.195 0.225 A 405 395 0 0 0 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6P5MB O75116 18 417 1388.0 O1S:62500 Type1 Inactive DFGin 6.251 13.644 BLAminus DFGAsp-rot-in -124.65, 169.29 60.65, 93.77 209.39, -32.26 -114.08, 30.09 303.05, 96.36 -58.22, -30.22 in-in in 8.643 Saltbr-in 2.831 HRD-in -79.09, -57.01 92.03, -28.0 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -109.09, 158.86 APE9-dihe-na -92.72, -122.33 APE8-dihe-in -76.3, 130.79 APE8-rot-out 86.08 APE67-dihe-in -53.57, -38.7 -80.54, 4.1 APE12-dist-out 6.637 APE11-dist-in 9.261 APE10-dist-in 7.384 APE9-dist-out 9.094 F270Y None None XRAY 2.65 0.195 0.225 B 405 387 0 0 0 0 [[92, 354]] 1.0 6p5m AGC_ROCK2_HUMAN AGC 1.8e-93 318.4 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8XA O75116 32 417 1388.0 YDW:501 Type1 Active DFGin 6.358 13.618 BLAminus DFGAsp-rot-in -145.81, -178.89 53.82, 76.54 193.51, 1.98 -97.16, 31.49 303.8, 87.87 -66.69, -28.82 in-in in 8.957 Saltbr-in 2.665 HRD-in -74.39, -58.56 77.08, -1.86 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.16, 162.89 APE9-dihe-na 114.79, -140.41 APE8-dihe-in -127.19, 138.75 APE8-rot-in 307.63 APE67-dihe-in -63.05, -28.14 -61.81, -39.49 APE12-dist-in 10.396 APE11-dist-in 11.705 APE10-dist-in 5.857 APE9-dist-in 3.8 None None None XRAY 2.6 0.201 0.253 A 391 380 0 0 0 0 [[92, 354]] 1.0 8x8x AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8XB O75116 29 417 1388.0 YDW:501 Type1 Inactive DFGin 6.473 13.541 BLAminus DFGAsp-rot-in -147.7, 178.94 53.55, 85.93 181.61, -1.18 -102.48, 38.62 301.82, 90.81 -61.05, -30.52 in-in in 8.773 Saltbr-in 2.88 HRD-in -76.73, -58.01 80.73, -14.45 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -122.98, 163.07 APE9-dihe-na -99.31, -128.88 APE8-dihe-in -61.96, 135.88 APE8-rot-out 70.76 APE67-dihe-in -50.09, -36.4 -79.46, -6.55 APE12-dist-out 6.731 APE11-dist-in 8.344 APE10-dist-in 6.744 APE9-dist-out 9.333 None None None XRAY 2.6 0.201 0.253 B 391 374 9 0 0 9 [[92, 354]] 1.0 8x8x AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8X8YA O75116 31 417 1388.0 YEA:501 Type1 Inactive DFGin 6.131 13.123 BLAminus DFGAsp-rot-in -148.21, -169.14 44.6, 71.48 187.67, 1.12 -91.3, 16.21 306.78, 89.53 -42.97, -27.25 in-in in 8.402 Saltbr-in 2.828 HRD-out -91.42, 96.9 -78.93, 1.22 in-in-out SNCiio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.94, 153.9 APE9-dihe-na 130.12, -144.45 APE8-dihe-in -138.71, 148.43 APE8-rot-out 78.56 APE67-dihe-in -57.28, -22.24 -69.59, -38.91 APE12-dist-in 10.854 APE11-dist-in 11.829 APE10-dist-in 5.997 APE9-dist-in 4.052 None None None XRAY 3.2 0.185 0.243 A 391 378 0 0 0 0 [[92, 354]] 1.0 8x8y AGC_ROCK2_HUMAN AGC 2.2e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVA O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.247 13.293 BLAminus DFGAsp-rot-in -141.83, 172.55 62.54, 72.12 201.83, 0.32 -93.6, 17.75 301.11, 105.91 -60.63, -17.81 in-in in 8.505 Saltbr-in 2.645 HRD-in -61.37, -48.09 70.0, -5.6 in-in-out SNCiio in-out ActLoopNT-in 3.104 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.41 APE8-rot-out 35.63 APE67-dihe-in -72.9, -30.33 -60.06, -49.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 A 395 377 12 0 0 6 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVB O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.272 13.248 BLAminus DFGAsp-rot-in -142.1, 173.55 61.9, 71.69 203.02, 2.17 -93.43, 17.34 301.23, 105.57 -59.73, -16.68 in-in in 8.529 Saltbr-in 2.63 HRD-in -62.93, -47.02 69.4, -4.67 in-in-none SNCiin in-none ActLoopNT-in 3.098 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.0, -25.51 999.0, -48.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 B 395 378 11 0 0 8 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVC O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.268 13.228 BLAminus DFGAsp-rot-in -142.15, 173.25 63.2, 71.86 200.52, 7.51 -94.04, 16.61 301.5, 104.97 -62.04, -13.94 in-in in 8.376 Saltbr-in 2.755 HRD-in -63.91, -46.28 70.58, -6.77 in-in-out SNCiio in-out ActLoopNT-in 3.102 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.71 APE8-dihe-in -13.99, 103.33 APE8-rot-out 49.66 APE67-dihe-in -50.5, -34.0 -98.95, 10.78 APE12-dist-out 6.115 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.443 None None None XRAY 2.586 0.185 0.217 C 395 389 3 0 0 2 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVD O75116 25 417 1388.0 VFS:501 Type1 None DFGin 6.243 13.357 BLAminus DFGAsp-rot-in -142.23, 173.1 61.78, 71.13 202.33, 1.42 -91.99, 20.3 301.3, 105.37 -69.47, 5.8 in-in in 8.671 Saltbr-in 2.701 HRD-in -54.87, -50.75 69.64, -5.46 in-in-none SNCiin in-none ActLoopNT-in 3.181 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -32.28 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 D 395 361 26 0 0 15 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVE O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.298 13.257 BLAminus DFGAsp-rot-in -140.47, 172.73 62.89, 72.53 202.72, 4.17 -94.4, 16.26 301.6, 106.26 -62.28, -16.19 in-in in 8.454 Saltbr-in 2.74 HRD-in -64.4, -46.2 69.9, -8.61 in-in-none SNCiin in-none ActLoopNT-in 3.126 ActLoopCT-none nonTYR APEdihe_aanii APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.7 APE8-rot-in 314.77 APE67-dihe-in -47.56, -31.02 -61.45, -35.46 APE12-dist-in 8.281 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 E 395 385 4 0 0 3 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVF O75116 25 417 1388.0 VFS:502 Type1 Inactive DFGin 6.254 13.33 BLAminus DFGAsp-rot-in -142.21, 173.17 67.59, 68.13 239.48, -15.08 -95.04, 16.84 301.9, 107.53 -61.95, -15.75 in-in in 8.573 Saltbr-in 2.716 HRD-in -62.26, -47.83 69.9, -5.26 in-in-out SNCiio in-out ActLoopNT-in 3.098 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -82.91, 164.49 APE9-dihe-na 87.67, 168.25 APE8-dihe-in -79.05, 142.33 APE8-rot-out 46.7 APE67-dihe-in -72.13, -29.81 -50.42, -43.74 APE12-dist-in 8.146 APE11-dist-in 11.709 APE10-dist-in 5.779 APE9-dist-in 4.286 None None None XRAY 2.586 0.185 0.217 F 395 385 4 0 0 0 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVG O75116 23 417 1388.0 VFS:501 Type1 Inactive DFGin 6.268 13.207 BLAminus DFGAsp-rot-in -141.3, 172.73 62.62, 71.55 202.41, 0.66 -93.79, 17.44 301.31, 106.61 -60.9, -17.27 in-in in 8.357 Saltbr-in 2.619 HRD-in -63.54, -47.24 68.64, -6.0 in-in-out SNCiio in-out ActLoopNT-in 3.128 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.83 APE8-rot-out 39.24 APE67-dihe-in -74.92, -26.36 -51.82, -46.1 APE12-dist-in 10.126 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 G 395 388 3 0 0 3 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVH O75116 25 417 1388.0 VFS:501 Type1 Inactive DFGin 6.278 13.245 BLAminus DFGAsp-rot-in -141.88, 173.26 61.58, 72.11 202.0, 0.22 -93.64, 17.43 301.68, 105.86 -61.63, -15.37 in-in in 8.461 Saltbr-in 2.664 HRD-in -62.24, -47.57 69.31, -6.43 in-in-out SNCiio in-out ActLoopNT-in 3.111 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -73.76, 175.86 APE9-dihe-na 74.79, 179.62 APE8-dihe-in -84.69, 144.58 APE8-rot-out 45.29 APE67-dihe-in -73.44, -28.15 -53.28, -43.42 APE12-dist-in 8.553 APE11-dist-in 11.987 APE10-dist-in 5.969 APE9-dist-in 4.345 None None None XRAY 2.586 0.185 0.217 H 395 386 4 0 0 0 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTA O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.175 13.12 BLAminus DFGAsp-rot-in -142.97, 170.43 61.47, 81.89 188.72, -3.51 -100.92, 25.83 302.43, 103.03 -66.54, -18.35 in-in in 8.58 Saltbr-in 2.711 HRD-in -62.06, -54.07 74.24, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 115.83 APE8-rot-out 43.33 APE67-dihe-in -64.51, -30.07 -62.81, -50.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 A 399 377 12 0 0 6 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTB O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.165 13.121 BLAminus DFGAsp-rot-in -141.64, 172.76 58.92, 82.45 190.78, 5.59 -101.4, 24.85 302.94, 103.08 -64.88, -17.44 in-in in 8.698 Saltbr-in 2.739 HRD-in -62.47, -54.27 74.29, -0.05 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.99, -27.47 999.0, -54.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 B 399 376 13 0 0 8 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTC O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.176 13.095 BLAminus DFGAsp-rot-in -142.99, 169.96 64.19, 75.58 194.37, 21.45 -96.75, 25.55 303.7, 101.46 -67.43, -15.16 in-in in 8.527 Saltbr-in 2.706 HRD-in -63.08, -53.72 74.17, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.91 APE8-dihe-in -58.47, 131.63 APE8-rot-out 67.86 APE67-dihe-in -44.06, -35.52 -96.11, -4.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.775 None None None XRAY 2.214 0.211 0.249 C 399 386 6 0 0 4 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTD O75116 25 417 1388.0 VFA:501 Type1 None DFGin 6.159 13.16 BLAminus DFGAsp-rot-in -143.53, 169.89 61.25, 83.67 196.73, -7.36 -103.29, 25.02 302.97, 101.79 -66.66, -17.12 in-in in 8.73 Saltbr-in 2.74 HRD-in -61.61, -54.54 74.16, -0.65 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.7 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 D 399 360 27 0 0 15 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTE O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.214 13.058 BLAminus DFGAsp-rot-in -142.23, 169.06 60.85, 86.77 193.22, -6.74 -104.6, 25.19 302.23, 103.83 -66.31, -19.22 in-in in 8.573 Saltbr-in 2.668 HRD-in -56.89, -52.9 74.38, -3.32 in-in-none SNCiin in-none ActLoopNT-in 3.044 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.83 APE8-rot-in 306.93 APE67-dihe-in -51.63, -28.56 -78.96, -16.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 E 399 384 5 0 0 4 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTF O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.159 13.217 BLAminus DFGAsp-rot-in -143.26, 173.18 61.07, 77.1 195.16, -1.39 -97.98, 23.74 303.85, 102.16 -65.15, -17.6 in-in in 8.72 Saltbr-in 2.687 HRD-in -62.56, -52.92 74.79, -2.1 in-in-out SNCiio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -119.34, 164.51 APE9-dihe-na 111.51, 140.88 APE8-dihe-in -67.31, 148.28 APE8-rot-out 57.04 APE67-dihe-in -67.65, -28.23 -51.9, -44.63 APE12-dist-in 9.735 APE11-dist-in 11.369 APE10-dist-in 5.75 APE9-dist-in 3.976 None None None XRAY 2.214 0.211 0.249 F 399 385 4 0 0 0 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTG O75116 23 417 1388.0 VFA:501 Type1 Inactive DFGin 6.197 13.07 BLAminus DFGAsp-rot-in -143.43, 168.41 64.09, 78.4 194.55, 13.16 -99.56, 26.13 303.07, 104.77 -66.2, -17.95 in-in in 8.653 Saltbr-in 2.684 HRD-in -63.78, -53.8 74.38, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.991 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.13 APE8-rot-out 59.5 APE67-dihe-in -66.38, -28.99 -52.8, -45.16 APE12-dist-in 10.947 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 G 399 388 3 0 0 3 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTH O75116 25 417 1388.0 VFA:501 Type1 Inactive DFGin 6.183 13.103 BLAminus DFGAsp-rot-in -143.87, 172.69 61.19, 80.41 196.64, -13.97 -100.34, 25.34 303.5, 101.89 -66.59, -15.9 in-in in 8.671 Saltbr-in 2.657 HRD-in -62.35, -53.45 73.79, -2.54 in-in-out SNCiio in-out ActLoopNT-in 3.006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.01, 163.73 APE9-dihe-na 113.76, 141.54 APE8-dihe-in -65.64, 151.02 APE8-rot-out 56.73 APE67-dihe-in -67.63, -28.53 -53.68, -45.01 APE12-dist-in 9.876 APE11-dist-in 11.58 APE10-dist-in 5.88 APE9-dist-in 4.073 None None None XRAY 2.214 0.211 0.249 H 399 386 4 0 0 0 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NA O75116 24 417 1388.0 5YS:501 Type1 Inactive DFGin 5.96 12.892 BLAminus DFGAsp-rot-in -147.52, 173.21 55.09, 95.25 189.13, -5.22 -112.31, 21.69 306.93, 92.98 -47.43, -30.39 in-in in 8.608 Saltbr-in 2.86 HRD-in -68.21, -48.5 74.44, -76.91 in-in-out SNCiio in-out ActLoopNT-in 3.192 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -137.17, 134.7 APE9-dihe-na 66.08, 179.98 APE8-dihe-in -79.2, 152.03 APE8-rot-out 39.36 APE67-dihe-in -55.24, -42.06 -64.41, -46.65 APE12-dist-none 999.0 APE11-dist-in 9.536 APE10-dist-in 6.756 APE9-dist-out 7.061 None None None XRAY 3.0 0.186 0.288 A 399 384 6 0 0 3 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NB O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.918 12.908 BLAminus DFGAsp-rot-in -147.26, 173.64 54.74, 95.37 187.69, -2.0 -112.38, 21.14 305.76, 93.69 -46.34, -30.83 in-in in 8.658 Saltbr-in 2.852 HRD-in -68.62, -48.31 74.92, -77.15 in-in-out SNCiio in-out ActLoopNT-in 3.196 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.85 APE8-rot-out 38.72 APE67-dihe-in -58.22, -39.82 -64.87, -46.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 B 399 385 8 0 0 4 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NC O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.934 12.92 BLAminus DFGAsp-rot-in -146.55, 173.64 55.03, 95.19 187.78, -1.64 -112.85, 21.67 306.28, 93.38 -46.66, -30.29 in-in in 8.672 Saltbr-in 2.845 HRD-in -68.54, -48.47 75.35, -77.76 in-in-none SNCiin in-none ActLoopNT-in 3.188 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -54.16, -41.45 999.0, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 C 399 378 12 0 0 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6ND O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.911 12.887 BLAminus DFGAsp-rot-in -147.57, 174.08 54.32, 95.38 187.76, -2.07 -112.83, 20.77 305.2, 94.02 -46.7, -30.3 in-in in 8.646 Saltbr-in 2.846 HRD-in -68.81, -47.96 75.21, -77.34 in-in-out SNCiio in-out ActLoopNT-in 3.191 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -138.24, 168.24 APE9-dihe-na 66.25, -164.28 APE8-dihe-in -79.15, 151.39 APE8-rot-out 38.92 APE67-dihe-in -57.2, -39.94 -65.63, -47.15 APE12-dist-in 12.872 APE11-dist-in 11.224 APE10-dist-in 6.119 APE9-dist-out 7.012 None None None XRAY 3.0 0.186 0.288 D 399 385 4 0 0 0 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NE O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.955 12.867 BLAminus DFGAsp-rot-in -145.98, 174.14 54.43, 95.4 188.02, -2.13 -112.52, 20.29 306.04, 93.17 -47.1, -30.89 in-in in 8.6 Saltbr-in 2.849 HRD-in -68.77, -48.13 75.51, -77.25 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.16, -41.37 999.0, -45.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 E 399 385 6 0 0 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NF O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.926 12.924 BLAminus DFGAsp-rot-in -146.77, 174.8 54.66, 94.69 188.29, -1.43 -112.86, 21.29 304.94, 93.72 -46.03, -30.46 in-in in 8.659 Saltbr-in 2.846 HRD-in -68.6, -48.35 74.88, -77.16 in-in-out SNCiio in-out ActLoopNT-in 3.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -139.14, 168.92 APE9-dihe-na 66.99, -163.85 APE8-dihe-in -78.8, 151.2 APE8-rot-out 38.36 APE67-dihe-in -57.1, -40.42 -65.28, -46.28 APE12-dist-in 11.587 APE11-dist-in 11.279 APE10-dist-in 6.163 APE9-dist-out 7.029 None None None XRAY 3.0 0.186 0.288 F 399 384 5 0 0 0 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NG O75116 25 417 1388.0 5YS:501 Type1 Inactive DFGin 5.96 12.872 BLAminus DFGAsp-rot-in -147.02, 173.65 54.4, 95.21 187.56, -0.73 -112.65, 21.16 306.2, 93.32 -46.85, -30.81 in-in in 8.614 Saltbr-in 2.845 HRD-in -68.3, -48.58 74.65, -77.07 in-in-out SNCiio in-out ActLoopNT-in 3.193 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.91 APE8-rot-out 38.81 APE67-dihe-in -55.86, -41.48 -64.55, -46.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 G 399 385 4 0 0 4 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NH O75116 25 417 1388.0 5YS:501 Type1 None DFGin 5.924 12.987 BLAminus DFGAsp-rot-in -147.12, 173.74 54.77, 95.23 188.53, -1.37 -112.35, 21.15 305.58, 93.62 -44.02, -31.78 in-in in 8.754 Saltbr-in 2.84 HRD-in -68.48, -48.35 74.56, -77.19 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.65, -39.86 999.0, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 H 399 366 23 0 0 15 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OA O75116 24 417 1388.0 5YK:501 Type1 Inactive DFGin 6.015 13.121 BLAminus DFGAsp-rot-in -129.99, 173.74 63.69, 84.38 192.89, 2.68 -107.33, 35.64 304.65, 101.12 -72.03, -45.78 in-in in 8.633 Saltbr-in 2.758 HRD-in -67.26, -41.63 68.26, 2.18 in-in-out SNCiio in-out ActLoopNT-in 3.222 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -114.07, 159.24 APE9-dihe-na -78.74, -160.5 APE8-dihe-in -69.68, 142.93 APE8-rot-out 53.5 APE67-dihe-in -55.96, -37.76 -73.63, -19.8 APE12-dist-in 10.328 APE11-dist-out 7.637 APE10-dist-out 8.578 APE9-dist-in 5.505 None None None XRAY 2.75 0.241 0.286 A 399 388 2 0 0 2 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OB O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.03 13.117 BLAminus DFGAsp-rot-in -130.02, 173.83 63.76, 84.52 192.81, 2.56 -107.31, 35.45 304.31, 101.62 -71.82, -45.98 in-in in 8.654 Saltbr-in 2.759 HRD-in -67.3, -41.49 68.16, 2.38 in-in-out SNCiio in-out ActLoopNT-in 3.22 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.81 APE8-rot-out 53.14 APE67-dihe-in -56.68, -36.81 -74.24, -19.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 B 399 379 12 0 0 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OD O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.029 13.115 BLAminus DFGAsp-rot-in -130.14, 174.07 63.77, 84.08 193.23, 2.45 -107.41, 35.57 304.55, 101.36 -72.14, -45.87 in-in in 8.684 Saltbr-in 2.758 HRD-in -67.39, -41.46 68.03, 2.41 in-in-out SNCiio in-out ActLoopNT-in 3.22 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_inii APE10-dihe-na 999.0, 157.1 APE9-dihe-na 77.73, 175.48 APE8-dihe-in -69.48, 142.35 APE8-rot-out 52.81 APE67-dihe-in -56.84, -36.56 -74.86, -19.55 APE12-dist-in 9.475 APE11-dist-none 999.0 APE10-dist-in 5.383 APE9-dist-in 5.499 None None None XRAY 2.75 0.241 0.286 D 399 384 5 0 0 1 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OE O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.038 13.104 BLAminus DFGAsp-rot-in -130.06, 173.52 64.1, 84.65 192.52, 2.28 -107.82, 35.44 304.2, 101.68 -73.02, -45.03 in-in in 8.651 Saltbr-in 2.759 HRD-in -67.66, -41.03 68.51, 2.53 in-in-out SNCiio in-out ActLoopNT-in 3.225 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.96 APE67-dihe-in -55.98, -37.45 -73.98, -19.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 E 399 385 5 0 0 5 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OF O75116 25 417 1388.0 5YK:501 Type1 Inactive DFGin 6.029 13.124 BLAminus DFGAsp-rot-in -130.14, 174.06 63.83, 84.14 193.07, 2.43 -107.45, 35.57 304.61, 101.55 -72.27, -45.71 in-in in 8.68 Saltbr-in 2.757 HRD-in -67.35, -41.53 67.92, 2.62 in-in-out SNCiio in-out ActLoopNT-in 3.221 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.42, 157.65 APE9-dihe-na 77.78, 174.44 APE8-dihe-in -69.32, 142.43 APE8-rot-out 52.91 APE67-dihe-in -56.82, -36.56 -74.83, -19.59 APE12-dist-in 11.241 APE11-dist-in 10.691 APE10-dist-in 5.366 APE9-dist-in 5.473 None None None XRAY 2.75 0.241 0.286 F 399 383 6 0 0 1 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6PA O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.144 13.498 BLAminus DFGAsp-rot-in -132.07, 172.67 54.56, 93.15 193.54, 2.87 -112.26, 31.75 305.01, 96.0 -65.02, -28.17 in-in in 8.936 Saltbr-in 2.708 HRD-in -75.76, -48.68 68.71, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.02 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_onoo APE10-dihe-na 999.0, -37.69 APE9-dihe-na 68.06, 165.75 APE8-dihe-out 49.49, 69.05 APE8-rot-out 51.42 APE67-dihe-in -43.22, -41.5 -67.31, -24.58 APE12-dist-out 5.896 APE11-dist-none 999.0 APE10-dist-out 8.815 APE9-dist-out 9.313 None None None XRAY 2.82 0.222 0.258 A 399 389 1 0 0 1 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6PB O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.154 13.387 BLAminus DFGAsp-rot-in -129.93, 173.86 61.04, 88.71 193.04, 3.57 -108.06, 31.11 304.98, 97.36 -66.26, -28.42 in-in in 8.705 Saltbr-in 3.12 HRD-in -76.63, -48.03 68.67, 4.31 in-in-out SNCiio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.26 APE8-rot-out 47.95 APE67-dihe-in -44.6, -41.1 -70.73, -25.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 B 399 374 15 0 0 12 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6PC O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.183 13.438 BLAminus DFGAsp-rot-in -129.72, 174.14 60.9, 87.88 194.34, 5.49 -108.85, 31.32 304.91, 96.4 -66.49, -26.92 in-in in 8.717 Saltbr-in 3.122 HRD-in -77.5, -47.77 68.57, 3.01 in-in-out SNCiio in-out ActLoopNT-in 3.028 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.51 APE8-rot-out 47.87 APE67-dihe-in -49.24, -39.17 -68.89, -25.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.82 0.222 0.258 C 399 378 12 0 0 11 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6PD O75116 24 417 1388.0 5YV:501 Type1 Inactive DFGin 6.138 13.388 BLAminus DFGAsp-rot-in -129.14, 174.38 61.55, 87.6 194.51, 4.03 -108.19, 31.9 304.73, 96.8 -65.3, -27.92 in-in in 8.755 Saltbr-in 3.139 HRD-in -76.81, -47.84 67.84, 3.94 in-in-out SNCiio in-out ActLoopNT-in 3.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -134.04, 138.37 APE9-dihe-na 76.18, 149.98 APE8-dihe-in -41.73, 133.73 APE8-rot-out 47.62 APE67-dihe-in -47.73, -39.5 -71.48, -25.27 APE12-dist-in 11.03 APE11-dist-in 11.225 APE10-dist-in 6.139 APE9-dist-in 5.154 None None None XRAY 2.82 0.222 0.258 D 399 383 6 0 0 2 [[92, 354]] 1.0 7p6p AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6QA O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.354 13.352 BLAminus DFGAsp-rot-in -144.62, 167.8 60.55, 87.07 186.69, 10.21 -103.28, 32.93 301.59, 102.75 -70.91, -20.49 in-in in 8.624 Saltbr-in 2.704 HRD-in -68.26, -48.48 72.01, -4.52 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.2 APE8-rot-out 61.47 APE67-dihe-in -43.02, -40.39 -80.11, -25.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 A 399 377 13 0 0 12 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6QB O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.3 13.309 BLAminus DFGAsp-rot-in -144.44, 167.29 60.61, 86.93 185.84, 11.75 -103.67, 32.19 301.37, 101.58 -69.29, -21.55 in-in in 8.607 Saltbr-in 2.913 HRD-in -66.9, -49.14 71.14, -2.98 in-in-out SNCiio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.87 APE8-rot-out 59.05 APE67-dihe-in -44.93, -40.33 -80.35, -26.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.89 0.209 0.266 B 399 374 15 0 0 12 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6QC O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.285 13.348 BLAminus DFGAsp-rot-in -141.89, 172.56 57.11, 86.76 185.71, 10.31 -103.5, 32.32 300.6, 102.23 -70.12, -20.17 in-in in 8.637 Saltbr-in 2.917 HRD-in -68.26, -48.37 71.29, -4.5 in-in-out SNCiio in-out ActLoopNT-in 2.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnio APE10-dihe-na 999.0, 162.63 APE9-dihe-na 97.71, -154.08 APE8-dihe-in -75.95, 125.62 APE8-rot-out 63.5 APE67-dihe-in -42.44, -40.72 -78.86, -26.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.941 APE9-dist-out 7.996 None None None XRAY 2.89 0.209 0.266 C 399 387 2 0 0 2 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6QD O75116 24 417 1388.0 5YO:501 Type1 Inactive DFGin 6.282 13.277 BLAminus DFGAsp-rot-in -144.35, 168.09 60.51, 86.98 186.96, 10.84 -102.62, 32.26 301.67, 102.33 -72.56, -19.6 in-in in 8.626 Saltbr-in 2.915 HRD-in -67.92, -48.44 71.11, -3.01 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -97.55, 159.64 APE9-dihe-na 118.49, 149.2 APE8-dihe-in -71.69, 137.89 APE8-rot-out 54.73 APE67-dihe-in -45.23, -39.33 -77.36, -30.49 APE12-dist-in 12.61 APE11-dist-in 11.471 APE10-dist-in 5.784 APE9-dist-in 5.207 None None None XRAY 2.89 0.209 0.266 D 399 383 6 0 0 2 [[92, 354]] 1.0 7p6q AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9EP8A O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.493 13.475 BLAminus DFGAsp-rot-in -142.27, 178.16 56.28, 74.06 197.1, 5.14 -91.93, 27.01 300.49, 98.73 -80.86, -4.32 in-in in 8.419 Saltbr-in 2.607 HRD-in -71.36, -50.57 66.41, 13.03 in-in-out SNCiio in-out ActLoopNT-in 3.218 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -143.44, 141.63 APE9-dihe-na -72.89, -103.54 APE8-dihe-in -98.04, 136.1 APE8-rot-out 54.66 APE67-dihe-in -51.08, -38.13 -83.55, -17.15 APE12-dist-in 8.78 APE11-dist-in 8.963 APE10-dist-out 9.224 APE9-dist-out 8.818 None None None XRAY 2.63 0.203 0.242 A 402 388 2 0 0 2 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9EP8B O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.722 13.605 BLAminus DFGAsp-rot-in -148.7, 178.5 52.93, 72.5 197.19, 7.45 -93.23, 28.49 302.13, 99.55 -80.04, -2.24 in-in in 8.381 Saltbr-in 2.629 HRD-in -69.68, -48.04 67.21, 12.72 in-in-out SNCiio in-out ActLoopNT-in 3.241 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.96 APE8-rot-out 55.95 APE67-dihe-in -50.85, -37.73 -82.2, -18.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 B 402 373 16 0 0 12 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9EP8C O75116 24 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.787 13.697 BLAminus DFGAsp-rot-in -142.98, 175.13 56.66, 74.33 194.46, 11.66 -94.91, 33.23 302.61, 100.99 -80.72, -3.65 in-in in 8.33 Saltbr-in 2.628 HRD-in -69.86, -50.69 67.71, 13.64 in-in-out SNCiio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.91 APE8-rot-out 55.45 APE67-dihe-in -48.54, -38.52 -80.78, -17.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.63 0.203 0.242 C 402 375 15 0 0 12 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9EP8D O75116 22 417 1388.0 A1H6L:60501 Type1 Inactive DFGin 6.533 13.515 BLAminus DFGAsp-rot-in -145.65, 177.68 55.35, 73.4 200.44, -1.14 -93.14, 26.37 302.82, 99.26 -82.32, -4.28 in-in in 8.499 Saltbr-in 2.612 HRD-in -71.04, -48.63 67.32, 7.83 in-in-out SNCiio in-out ActLoopNT-in 3.252 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.28, 155.4 APE9-dihe-na -71.41, -102.58 APE8-dihe-in -87.31, 137.03 APE8-rot-out 55.19 APE67-dihe-in -49.79, -38.66 -81.91, -22.13 APE12-dist-in 8.001 APE11-dist-in 8.683 APE10-dist-out 8.126 APE9-dist-out 6.719 None None None XRAY 2.63 0.203 0.242 D 402 386 5 0 0 2 [[92, 354]] 1.0 9ep8 AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6A O75116 27 415 1388.0 J0P:501 Type1 Active DFGin 6.479 13.361 BLAminus DFGAsp-rot-in -145.19, 179.01 60.98, 63.29 195.62, 15.02 -87.07, 23.13 303.43, 107.85 -60.41, -48.86 in-in in 8.532 Saltbr-in 2.744 HRD-in -56.44, -54.27 71.45, -18.59 in-in-in SNCiii in-in ActLoopNT-in 3.439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.8, 126.02 APE9-dihe-na 153.03, -163.23 APE8-dihe-in -114.06, 130.07 APE8-rot-in 328.57 APE67-dihe-in -55.65, -29.13 -25.97, -72.15 APE12-dist-in 10.492 APE11-dist-in 11.382 APE10-dist-in 5.553 APE9-dist-in 3.96 None None None XRAY 2.86 0.206 0.247 A 415 378 4 0 0 0 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.7e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.02 13.098 BLAminus DFGAsp-rot-in -129.77, 174.02 63.85, 83.94 193.25, 3.03 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.669 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.222 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399 377 13 0 0 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OG O75116 25 417 1388.0 5YK:501 Type1.5_Front Inactive DFGin 6.03 13.093 BLAminus DFGAsp-rot-in -130.18, 173.76 63.87, 84.33 192.84, 2.47 -107.4, 35.32 304.41, 101.68 -72.33, -45.62 in-in in 8.657 Saltbr-in 2.757 HRD-in -67.47, -41.36 68.16, 2.55 in-in-out SNCiio in-out ActLoopNT-in 3.223 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.09 APE8-rot-out 52.99 APE67-dihe-in -56.93, -36.54 -73.99, -19.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 G 399 381 8 0 0 5 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.031 13.142 BLAminus DFGAsp-rot-in -130.18, 173.86 63.9, 84.23 193.08, 2.31 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.685 Saltbr-in 2.757 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.218 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399 369 19 0 0 14 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 6ED6B O75116 28 416 1388.0 J0P:501 Type1.5_Front Inactive DFGin 6.399 13.183 BLAminus DFGAsp-rot-in -141.53, 178.3 54.07, 109.38 181.19, -78.21 -133.99, 38.6 302.74, 88.83 -73.72, -23.58 in-in in 8.537 Saltbr-in 2.814 HRD-in -63.89, -44.38 75.08, -45.12 in-in-out SNCiio in-out ActLoopNT-in 3.574 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.55 APE8-dihe-in -56.82, 118.75 APE8-rot-in 295.99 APE67-dihe-in -40.0, -36.43 -89.99, -12.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.059 None None None XRAY 2.86 0.206 0.247 B 415 364 18 0 0 12 [[92, 354]] 1.0 6ed6 AGC_ROCK2_HUMAN AGC 2.7e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 5U7RD O75116 25 417 1388.0 81G:500 Type1 Inactive DFGin 5.991 13.638 None DFGAsp-rot-in -137.02, -44.53 -96.66, 83.52 191.1, 14.5 -88.69, 16.85 303.92, 107.42 -55.18, -36.04 in-in in 8.733 Saltbr-in 2.74 HRD-in -81.59, -27.48 68.65, -73.51 in-in-out SNCiio in-out ActLoopNT-in 3.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -137.68 APE8-dihe-in -113.15, 136.27 APE8-rot-out 64.84 APE67-dihe-in -28.57, -52.13 -70.74, -29.02 APE12-dist-out 6.843 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.712 None None None XRAY 3.33 0.202 0.241 D 395 382 5 0 0 2 [[92, 354]] 1.0 5u7r AGC_ROCK2_HUMAN AGC 1.7e-93 318.5 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9JCUA O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.306 9.619 BBAminus DFGAsp-rot-in -122.68, 142.57 -93.88, 117.42 182.99, 27.6 -92.58, 35.45 292.89, 171.91 87.13, 16.18 out-out out 14.623 Saltbr-out 18.487 HRD-in -80.95, -50.27 68.09, 7.79 out-in-out SNCoio in-out ActLoopNT-in 2.962 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -127.11, 146.68 APE9-dihe-na -74.38, -64.25 APE8-dihe-in -92.78, 136.35 APE8-rot-out 52.4 APE67-dihe-in -50.05, -29.64 -108.42, 7.1 APE12-dist-in 7.399 APE11-dist-in 9.333 APE10-dist-in 7.297 APE9-dist-out 9.366 None None None XRAY 3.02 0.186 0.22 A 391 389 0 0 0 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9JCUC O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.271 9.765 BBAminus DFGAsp-rot-in -106.39, 150.48 -108.17, 107.09 169.78, 31.52 -89.63, 40.89 296.67, 171.34 75.24, 36.56 out-out out 14.753 Saltbr-out 15.878 HRD-in -75.77, -43.93 77.36, -10.14 out-in-out SNCoio in-out ActLoopNT-in 2.922 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.94, 167.95 APE9-dihe-na 94.03, 133.64 APE8-dihe-in -78.46, 149.57 APE8-rot-out 190.58 APE67-dihe-in -65.59, -41.68 -57.26, -43.03 APE12-dist-in 9.766 APE11-dist-in 11.57 APE10-dist-in 5.772 APE9-dist-in 4.162 None None None XRAY 3.02 0.186 0.22 C 391 389 0 0 0 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSA O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.304 9.395 BBAminus DFGAsp-rot-in -113.16, 143.54 -102.55, 117.32 168.47, 39.92 -102.58, 29.06 302.77, 145.94 110.64, 5.22 out-out out 15.079 Saltbr-out 13.966 HRD-in -62.18, -48.44 83.82, -31.03 out-in-out SNCoio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -67.31, -53.4 APE9-dihe-na 75.32, -130.78 APE8-dihe-in -73.21, 128.78 APE8-rot-in 285.89 APE67-dihe-in -37.36, -36.42 -96.83, -9.21 APE12-dist-none 999.0 APE11-dist-out 7.256 APE10-dist-out 9.851 APE9-dist-out 9.407 None None None XRAY 2.71 0.218 0.248 A 396 384 6 0 0 2 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSB O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.39 9.51 BBAminus DFGAsp-rot-in -111.96, 142.39 -102.56, 118.41 164.88, 44.33 -101.87, 25.6 301.02, 146.14 115.08, 0.13 out-none out 14.902 Saltbr-none 999.0 HRD-in -65.01, -47.29 71.28, -3.57 none-in-out SNCnio in-out ActLoopNT-in 2.858 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -134.25, 147.87 APE9-dihe-na -136.74, -95.28 APE8-dihe-in -67.87, 115.24 APE8-rot-in 324.97 APE67-dihe-in -41.62, -33.28 -83.99, -16.64 APE12-dist-none 999.0 APE11-dist-out 5.672 APE10-dist-out 9.854 APE9-dist-out 8.947 None None None XRAY 2.71 0.218 0.248 B 396 384 6 0 0 3 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSC O75116 24 417 1388.0 Z8O:501 Type1 Inactive DFGout 14.447 9.401 BBAminus DFGAsp-rot-in -113.01, 140.92 -102.45, 117.72 164.92, 44.74 -102.11, 26.89 300.53, 146.18 115.19, 0.27 out-none out 14.999 Saltbr-none 999.0 HRD-in -64.56, -46.59 70.99, -5.08 none-in-out SNCnio in-out ActLoopNT-in 2.887 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -88.19 APE8-dihe-in -78.06, 129.88 APE8-rot-out 60.88 APE67-dihe-in -45.28, -34.19 -66.72, -39.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.479 None None None XRAY 2.71 0.218 0.248 C 396 385 5 0 0 4 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 8GDSD O75116 24 417 1388.0 Z8O:501 Type1.5_Front Inactive DFGout 14.51 9.548 BBAminus DFGAsp-rot-in -103.86, 141.89 -103.51, 117.86 171.51, 42.11 -102.63, 25.16 306.33, 142.76 108.24, 20.62 out-none out 14.969 Saltbr-none 999.0 HRD-in -60.5, -48.74 68.07, -4.31 none-in-none SNCnin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 89.84 APE9-dihe-na 170.11, -172.34 APE8-dihe-in -98.69, 124.47 APE8-rot-in 291.85 APE67-dihe-in -51.67, -33.01 -41.58, -52.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.122 APE9-dist-in 4.517 None None None XRAY 2.71 0.218 0.248 D 396 379 10 0 0 5 [[92, 354]] 1.0 8gds AGC_ROCK2_HUMAN AGC 2.3e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9JCUB O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.093 9.676 None DFGAsp-rot-in -123.7, 136.79 -83.22, 129.55 192.84, 44.05 -106.53, 41.2 289.39, 2.91 73.26, 33.5 out-out out 14.2 Saltbr-out 17.823 HRD-in -77.91, -44.8 66.92, 1.93 out-in-out SNCoio in-out ActLoopNT-in 3.04 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -105.29, 171.74 APE9-dihe-na -102.18, -85.42 APE8-dihe-in -169.86, 135.89 APE8-rot-out 176.2 APE67-dihe-in -66.86, -26.38 -54.25, -48.1 APE12-dist-in 8.648 APE11-dist-out 7.525 APE10-dist-out 9.557 APE9-dist-in 3.648 None None None XRAY 3.02 0.186 0.22 B 391 389 0 0 0 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9JCUD O75116 27 417 1388.0 No_ligand No_ligand Inactive DFGout 15.189 10.046 None DFGAsp-rot-in 61.51, -151.7 -108.74, 133.46 161.91, 41.46 -95.46, 35.35 295.16, 171.82 82.43, 18.9 out-out out 14.645 Saltbr-out 15.482 HRD-in -89.16, -45.56 76.26, -7.28 out-in-out SNCoio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.41, 151.77 APE9-dihe-na 117.7, 163.08 APE8-dihe-in -78.12, 141.11 APE8-rot-out 189.43 APE67-dihe-in -63.04, -33.79 -53.94, -34.75 APE12-dist-in 11.041 APE11-dist-in 11.589 APE10-dist-in 5.952 APE9-dist-in 4.458 None None None XRAY 3.02 0.186 0.22 D 391 387 0 0 0 0 [[92, 354]] 1.0 9jcu AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K1A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.621 14.355 BLAminus DFGAsp-rot-in -124.04, -166.26 40.15, 63.05 204.37, 27.6 -75.14, 13.01 287.46, 77.73 -62.04, -17.57 in-in in 8.996 Saltbr-in 2.655 HRD-in -82.17, -49.64 65.88, 6.04 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.23, 164.1 APE9-dihe-na 113.31, 168.76 APE8-dihe-in -68.46, 130.82 APE8-rot-in 292.77 APE67-dihe-in -60.62, -26.43 -61.01, -40.77 APE12-dist-in 8.416 APE11-dist-in 11.406 APE10-dist-in 5.696 APE9-dist-in 3.493 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K1 AGC_RPS6KA1-1_HUMAN AGC 9.2e-96 325.9 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K3A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.446 14.352 BLAminus DFGAsp-rot-in -131.09, -177.74 50.28, 63.61 203.37, 13.88 -71.56, 10.34 294.57, 83.15 -62.78, -13.6 in-in in 8.88 Saltbr-in 2.663 HRD-in -82.73, -46.46 67.14, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.19, 164.66 APE9-dihe-na 112.66, 172.32 APE8-dihe-in -74.19, 134.18 APE8-rot-in 293.08 APE67-dihe-in -61.38, -26.34 -64.42, -40.72 APE12-dist-in 8.366 APE11-dist-in 11.432 APE10-dist-in 5.676 APE9-dist-in 3.387 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K3 AGC_RPS6KA1-1_HUMAN AGC 9.2e-96 325.9 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.532 13.12 BLAplus DFGAsp-rot-out -128.25, 170.81 61.53, 44.51 298.69, -55.87 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.134 Saltbr-out 8.897 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.509 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.42 APE10-dist-out 11.512 APE9-dist-out 7.639 None None None XRAY 2.55 0.206 0.252 A 321 261 24 0 0 9 [[62, 321], [418, 675]] 2.0 8xov AGC_RPS6KA1-1_HUMAN AGC 1.6e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.028 12.369 BLBplus DFGAsp-rot-out -135.49, 158.95 63.12, 60.24 305.93, -80.03 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.053 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.791 None None None XRAY 2.0 0.264 0.283 A 321 255 30 0 0 12 [[62, 321], [418, 675]] 2.0 2z7q AGC_RPS6KA1-1_HUMAN AGC 1.6e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.928 12.322 BLBplus DFGAsp-rot-in -135.18, 169.76 58.7, 61.01 208.59, -2.83 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.378 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.754 None None None XRAY 2.0 0.255 0.286 A 321 265 23 0 0 12 [[62, 321], [418, 675]] 2.0 2z7r AGC_RPS6KA1-1_HUMAN AGC 1.6e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA1-1 KS6A1_HUMAN 2Z7SA Q15418 56 340 735.0 P01:1 Type1 Inactive DFGin 7.219 12.635 BLBplus DFGAsp-rot-out -132.64, 170.38 54.15, 50.71 280.48, -40.7 -114.94, -156.75 52.84, 81.1 107.65, -49.27 none-none none 999.0 Saltbr-none 999.0 HRD-out -71.6, 70.9 -56.92, -36.92 none-out-out SNCnoo out-out ActLoopNT-out 7.09 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.47 APE8-dihe-in -68.64, 105.29 APE8-rot-in 308.32 APE67-dihe-in -56.06, -20.75 -56.93, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.734 None None None XRAY 2.1 0.279 999.0 A 321 256 29 0 0 12 [[62, 321], [418, 675]] 2.0 2z7s AGC_RPS6KA1-1_HUMAN AGC 1.6e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA2-1 KS6A2_HUMAN AF-Q15349-K1A Q15349 51 326 733.0 No_ligand No_ligand Active DFGin 6.56 14.298 BLAminus DFGAsp-rot-in -128.83, -162.98 39.17, 62.6 202.27, 27.67 -73.7, 13.33 288.23, 79.39 -63.05, -17.58 in-in in 8.746 Saltbr-in 2.618 HRD-in -82.39, -49.82 64.45, 9.53 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.56, 163.19 APE9-dihe-na 114.31, 169.62 APE8-dihe-in -69.73, 130.78 APE8-rot-in 293.85 APE67-dihe-in -60.4, -27.19 -59.3, -42.05 APE12-dist-in 8.399 APE11-dist-in 11.444 APE10-dist-in 5.699 APE9-dist-in 3.539 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K1 AGC_RPS6KA2-1_HUMAN AGC 6.3e-97 329.7 1 260 260 201 202 203 205 207 91 109 113 181 183 182 184 241 229 224 223 222 221 220 219 218 139 Ribosomal protein S6 kinase alpha-2
AGC RPS6KA2-1 KS6A2_HUMAN AF-Q15349-K3A Q15349 51 326 733.0 No_ligand No_ligand Active DFGin 6.434 14.159 BLAminus DFGAsp-rot-in -128.23, -175.81 52.4, 64.67 204.58, 16.81 -72.62, 10.99 294.75, 82.08 -64.43, -12.72 in-in in 8.626 Saltbr-in 2.643 HRD-in -85.46, -48.02 66.82, 11.67 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.59, 164.28 APE9-dihe-na 111.5, 172.79 APE8-dihe-in -74.02, 136.08 APE8-rot-in 294.1 APE67-dihe-in -63.58, -25.11 -70.41, -35.48 APE12-dist-in 8.374 APE11-dist-in 11.421 APE10-dist-in 5.655 APE9-dist-in 3.388 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[59, 318], [415, 672]] 2.0 AF-Q15349-K3 AGC_RPS6KA2-1_HUMAN AGC 6.3e-97 329.7 1 260 260 201 202 203 205 207 91 109 113 181 183 182 184 241 229 224 223 222 221 220 219 218 139 Ribosomal protein S6 kinase alpha-2
AGC RPS6KA3-1 KS6A3_HUMAN 4NW5A P51812 51 359 740.0 2NR:1001 Type1 Inactive DFGin 6.865 13.918 ABAminus DFGAsp-rot-in -125.07, -26.39 -111.82, 108.74 195.68, -28.57 -107.62, 13.77 297.76, 84.36 -56.94, -37.48 in-in in 8.623 Saltbr-in 2.802 HRD-in -66.66, -50.7 69.74, -28.95 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.85, 144.89 APE9-dihe-na 119.11, -176.62 APE8-dihe-in -86.28, 123.64 APE8-rot-in 295.84 APE67-dihe-in -53.89, -25.82 -50.24, -49.0 APE12-dist-in 8.135 APE11-dist-in 11.049 APE10-dist-in 5.31 APE9-dist-in 4.808 None None None XRAY 1.94 0.175 0.219 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw5 AGC_RPS6KA3-1_HUMAN AGC 2.7e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 4NW6A P51812 51 359 740.0 2NS:1001 Type1 Inactive DFGin 6.782 13.904 ABAminus DFGAsp-rot-in -124.66, -15.73 -125.39, 119.67 191.69, -44.84 -114.93, 13.33 295.12, 83.78 -57.16, -34.75 in-in in 8.561 Saltbr-in 2.835 HRD-in -67.61, -47.75 68.59, -32.24 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.14, 147.51 APE9-dihe-na 118.99, -176.28 APE8-dihe-in -85.82, 124.26 APE8-rot-in 292.93 APE67-dihe-in -54.12, -25.71 -51.61, -49.13 APE12-dist-in 8.074 APE11-dist-in 10.959 APE10-dist-in 5.215 APE9-dist-in 4.928 None None None XRAY 1.74 0.167 0.201 A 323 302 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nw6 AGC_RPS6KA3-1_HUMAN AGC 2.7e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN AF-P51812-K1A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.764 14.365 BLAminus DFGAsp-rot-in -128.08, -168.93 44.14, 64.08 203.55, 24.75 -76.47, 13.22 289.9, 79.47 -63.08, -17.42 in-in in 8.864 Saltbr-in 2.673 HRD-in -82.22, -48.58 63.74, 10.13 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.28, 165.34 APE9-dihe-na 113.22, 171.27 APE8-dihe-in -72.62, 129.88 APE8-rot-in 293.52 APE67-dihe-in -60.98, -26.44 -58.38, -41.01 APE12-dist-in 8.476 APE11-dist-in 11.414 APE10-dist-in 5.681 APE9-dist-in 3.536 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K1 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN AF-P51812-K3A P51812 60 335 740.0 No_ligand No_ligand Active DFGin 6.499 14.162 BLAminus DFGAsp-rot-in -131.58, -177.03 51.85, 64.94 202.82, 13.21 -73.26, 9.93 296.53, 86.04 -63.15, -12.88 in-in in 8.786 Saltbr-in 2.627 HRD-in -83.1, -49.32 68.04, 9.8 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.96, 166.11 APE9-dihe-na 108.7, 179.24 APE8-dihe-in -85.77, 132.92 APE8-rot-in 303.81 APE67-dihe-in -62.2, -27.77 -65.91, -38.69 APE12-dist-in 8.389 APE11-dist-in 11.43 APE10-dist-in 5.673 APE9-dist-in 3.362 None None None AF2 -1.0 1.0 1.0 A 276 276 0 0 0 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K3 AGC_RPS6KA3-1_HUMAN AGC 1.5e-97 331.7 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.64 11.283 None DFGAsp-rot-in -75.51, -9.72 -147.12, 169.74 200.33, -26.22 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.181 APE11-dist-out 18.834 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317 295 9 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.828 11.217 None DFGAsp-rot-in -75.62, -9.94 -146.57, 168.73 199.58, -25.98 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.132 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.693 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.742 11.315 None DFGAsp-rot-in -74.55, -8.16 -143.05, 166.95 196.78, 41.86 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.224 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.688 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317 292 11 0 0 3 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.743 11.055 None DFGAsp-rot-in -76.12, -10.81 -146.65, 168.53 200.64, -24.04 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.952 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.117 APE11-dist-out 17.377 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None DFGAsp-rot-in -75.13, -10.43 -146.35, 169.25 199.75, -26.56 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None DFGAsp-rot-in -75.68, -10.29 -146.32, 168.68 199.8, -24.84 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8EQ5A P51812 49 346 740.0 QCT:401 Type1 Inactive DFGout 22.266 9.787 None DFGAsp-rot-out -73.88, 137.17 -86.9, 13.11 82.66, -19.12 -125.85, 163.49 50.35, 92.47 -96.22, 152.3 none-none none 999.0 Saltbr-none 999.0 HRD-in -78.97, -41.58 76.84, -49.89 none-out-out SNCnoo out-out ActLoopNT-out 15.409 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -123.13, 112.05 APE9-dihe-na -120.61, 174.84 APE8-dihe-in -88.65, 114.78 APE8-rot-in 305.94 APE67-dihe-in -62.47, -20.15 -62.23, -32.4 APE12-dist-in 13.883 APE11-dist-in 11.461 APE10-dist-out 9.67 APE9-dist-out 7.056 None None None XRAY 1.8 0.185 0.225 A 305 289 9 0 0 2 [[68, 327], [422, 679]] 2.0 8eq5 AGC_RPS6KA3-1_HUMAN AGC 2.2e-97 331.2 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8R58A P51812 49 348 740.0 QCT:401 Type1 Inactive DFGout 22.723 9.734 None DFGAsp-rot-out -69.6, 133.49 -81.98, 4.89 85.63, -26.44 -117.98, 155.18 46.12, 100.26 -81.19, 145.71 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.36, -38.11 64.12, -42.77 none-out-out SNCnoo out-out ActLoopNT-out 15.002 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -64.62, 110.24 APE9-dihe-na -140.48, 179.06 APE8-dihe-in -91.85, 110.78 APE8-rot-in 305.36 APE67-dihe-in -59.58, -23.45 -59.81, -33.88 APE12-dist-none 999.0 APE11-dist-in 11.825 APE10-dist-out 8.908 APE9-dist-out 7.055 None None None XRAY 2.31 0.238 0.263 A 317 282 18 0 0 11 [[68, 327], [422, 679]] 2.0 8r58 AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA P51812 58 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.205 7.347 None DFGAsp-rot-out -84.69, 175.04 -98.49, -2.97 61.13, -54.73 -56.06, -41.49 288.51, 111.93 -88.04, -1.58 out-out out 13.584 Saltbr-out 12.491 HRD-out -102.98, 108.87 -62.66, -66.03 out-out-out SNCooo out-out ActLoopNT-out 5.29 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -171.34, 174.53 APE9-dihe-na 132.9, 150.52 APE8-dihe-in -54.44, 119.7 APE8-rot-in 325.6 APE67-dihe-in -67.51, -35.24 -72.39, -24.23 APE12-dist-none 999.0 APE11-dist-out 15.301 APE10-dist-out 13.362 APE9-dist-out 6.397 None None None XRAY 3.2 0.233 0.303 A 320 289 12 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB P51812 59 358 740.0 A1LU8:401 Type1 Inactive DFGout 12.476 7.622 None DFGAsp-rot-out -79.21, 172.69 -104.74, 14.38 64.24, -59.72 -72.96, -37.65 288.72, 121.74 -83.1, -14.53 out-out out 13.02 Saltbr-out 10.251 HRD-out -85.11, 105.26 -64.66, -55.07 out-out-out SNCooo out-out ActLoopNT-out 5.181 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -141.21, 158.45 APE9-dihe-na 119.59, 160.83 APE8-dihe-in -64.8, 132.56 APE8-rot-out 38.16 APE67-dihe-in -76.3, -33.52 -81.38, -10.91 APE12-dist-none 999.0 APE11-dist-out 15.912 APE10-dist-out 12.427 APE9-dist-out 6.369 None None None XRAY 3.2 0.233 0.303 B 320 277 23 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC P51812 61 358 740.0 A1LU8:401 Type1 Inactive DFGout 13.007 7.405 None DFGAsp-rot-out -74.08, -176.12 -117.42, 16.75 60.51, -63.91 -70.92, -31.59 288.86, 115.13 -89.42, -33.94 none-none none 999.0 Saltbr-none 999.0 HRD-out -99.11, 116.77 -79.3, -60.22 none-out-out SNCnoo out-out ActLoopNT-out 5.139 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -154.86, 91.8 APE9-dihe-na -163.03, 159.53 APE8-dihe-in -69.77, 116.03 APE8-rot-in 309.84 APE67-dihe-in -63.05, -25.35 -70.36, -29.8 APE12-dist-none 999.0 APE11-dist-out 15.692 APE10-dist-out 13.257 APE9-dist-out 6.185 None None None XRAY 3.2 0.233 0.303 C 320 272 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.68 7.718 None DFGAsp-rot-out -85.23, 171.03 -99.91, 5.18 61.22, -57.76 -66.56, -47.9 288.97, 119.73 -68.87, -42.49 none-none none 999.0 Saltbr-none 999.0 HRD-out -108.97, 107.04 -79.62, 147.57 none-out-out SNCnoo out-out ActLoopNT-out 5.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.66, -177.37 APE9-dihe-na 101.82, 157.81 APE8-dihe-in -62.84, 132.59 APE8-rot-out 47.92 APE67-dihe-in -68.43, -26.54 -77.35, -22.1 APE12-dist-none 999.0 APE11-dist-out 16.005 APE10-dist-out 13.641 APE9-dist-out 7.28 None None None XRAY 3.2 0.233 0.303 D 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE P51812 64 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.814 7.732 None DFGAsp-rot-out -79.79, 173.69 -104.44, 5.05 61.06, -59.58 -67.56, -37.65 296.33, 117.93 -76.73, -31.97 none-none none 999.0 Saltbr-none 999.0 HRD-out -107.95, 111.24 -79.69, -31.85 none-out-out SNCnoo out-out ActLoopNT-out 5.217 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -171.13, 156.06 APE9-dihe-na 118.15, 155.77 APE8-dihe-in -55.33, 128.86 APE8-rot-out 36.52 APE67-dihe-in -70.55, -22.72 -79.46, -18.88 APE12-dist-none 999.0 APE11-dist-out 16.556 APE10-dist-out 12.762 APE9-dist-in 5.579 None None None XRAY 3.2 0.233 0.303 E 320 261 24 0 0 9 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF P51812 63 345 740.0 A1LU8:401 Type1 Inactive DFGout 12.743 7.471 None DFGAsp-rot-out -95.59, -178.42 -108.18, 9.34 56.8, -50.92 -70.41, -40.72 293.14, 115.72 -77.9, -28.8 none-none none 999.0 Saltbr-none 999.0 HRD-out -100.4, 115.65 -68.34, -48.2 none-out-out SNCnoo out-out ActLoopNT-out 5.156 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -160.1, 173.9 APE9-dihe-na 114.4, 160.81 APE8-dihe-in -56.13, 119.9 APE8-rot-out 41.37 APE67-dihe-in -71.03, -16.28 -73.87, -18.19 APE12-dist-none 999.0 APE11-dist-out 15.392 APE10-dist-out 13.539 APE9-dist-out 6.404 None None None XRAY 3.2 0.233 0.303 F 320 255 28 0 0 11 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG P51812 59 346 740.0 A1LU8:401 Type1 Inactive DFGout 12.937 7.226 None DFGAsp-rot-out -78.16, 176.02 -98.19, 0.09 68.5, -44.06 -62.25, -40.75 291.8, 111.06 -81.64, -19.61 in-out in 7.881 Saltbr-out 5.486 HRD-out -91.07, 110.45 -88.21, -3.19 out-out-out SNCooo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -71.01, 158.33 APE9-dihe-na 129.65, 145.56 APE8-dihe-in -72.78, 126.88 APE8-rot-in 303.8 APE67-dihe-in -65.24, -40.51 -67.91, -29.47 APE12-dist-none 999.0 APE11-dist-out 16.145 APE10-dist-out 12.069 APE9-dist-in 4.644 None None None XRAY 3.2 0.233 0.303 G 320 276 12 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH P51812 59 348 740.0 A1LU8:401 Type1 Inactive DFGout 13.374 7.713 None DFGAsp-rot-out -77.26, -179.45 -100.74, 0.21 63.51, -29.39 -62.05, -41.28 291.33, 112.54 -80.3, -18.96 out-out out 12.403 Saltbr-out 7.869 HRD-out -114.7, 107.73 -80.32, -3.28 out-out-out SNCooo out-out ActLoopNT-out 5.561 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooi APE10-dihe-na -169.14, 166.07 APE9-dihe-na 97.31, 158.5 APE8-dihe-in -62.25, 138.33 APE8-rot-out 53.1 APE67-dihe-in -70.31, -30.08 -88.76, -15.85 APE12-dist-none 999.0 APE11-dist-out 15.688 APE10-dist-out 12.169 APE9-dist-in 5.119 None None None XRAY 3.2 0.233 0.303 H 320 277 13 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI P51812 63 348 740.0 A1LU8:401 Type1 Inactive DFGout 12.485 7.394 None DFGAsp-rot-out -79.8, 178.19 -107.54, 4.76 67.16, -65.32 -62.98, -39.18 294.19, 109.04 -76.4, -38.16 none-none none 999.0 Saltbr-none 999.0 HRD-out -110.77, 98.18 -69.66, 134.16 none-out-out SNCnoo out-out ActLoopNT-out 4.941 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -128.64, 168.96 APE9-dihe-na 103.76, 142.33 APE8-dihe-in -52.02, 130.9 APE8-rot-out 52.96 APE67-dihe-in -63.86, -32.68 -78.41, -20.46 APE12-dist-none 999.0 APE11-dist-out 16.546 APE10-dist-out 12.606 APE9-dist-out 6.609 None None None XRAY 3.2 0.233 0.303 I 320 260 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ P51812 65 347 740.0 A1LU8:401 Type1 Inactive DFGout 12.681 7.253 None DFGAsp-rot-out -82.1, 175.26 -103.79, -3.59 50.77, -4.72 -58.74, -48.51 291.22, 109.94 -83.23, -7.51 none-none none 999.0 Saltbr-none 999.0 HRD-out -111.91, 105.75 -75.45, -19.05 none-out-out SNCnoo out-out ActLoopNT-out 5.003 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -112.59, 166.79 APE9-dihe-na 114.55, 148.33 APE8-dihe-in -68.28, 140.99 APE8-rot-in 305.08 APE67-dihe-in -73.95, -40.89 -90.2, -12.76 APE12-dist-none 999.0 APE11-dist-out 16.562 APE10-dist-out 12.863 APE9-dist-in 5.003 None None None XRAY 3.2 0.233 0.303 J 320 257 26 0 0 10 [[68, 327], [422, 679]] 2.0 8xfy AGC_RPS6KA3-1_HUMAN AGC 2.6e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 4NUSA P51812 53 359 740.0 2NK:1001 Type1 Inactive DFGout 13.045 7.342 None DFGAsp-rot-out -78.78, 166.95 -80.65, -18.82 57.42, -57.63 -46.42, -28.2 293.03, 106.08 -107.82, 1.09 in-out in 9.447 Saltbr-out 3.913 HRD-out -114.59, 104.74 -76.23, -8.33 out-out-out SNCooo out-out ActLoopNT-out 5.209 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.74, 153.82 APE9-dihe-na 111.28, -177.73 APE8-dihe-in -92.12, 117.05 APE8-rot-in 306.83 APE67-dihe-in -54.85, -26.24 -45.49, -49.89 APE12-dist-in 13.431 APE11-dist-out 16.163 APE10-dist-out 10.59 APE9-dist-in 4.083 None None None XRAY 2.39 0.191 0.231 A 323 301 0 0 0 0 [[68, 327], [422, 679]] 2.0 4nus AGC_RPS6KA3-1_HUMAN AGC 2.7e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9LA P51812 49 359 740.0 583:1001 Type1 Inactive DFGout 13.125 7.071 None DFGAsp-rot-out -75.24, 167.74 -87.99, -6.69 57.83, -54.81 -50.57, -47.91 290.28, 116.72 -91.68, 11.14 in-out in 8.137 Saltbr-out 7.416 HRD-out -120.21, 105.54 -83.41, 126.5 out-out-out SNCooo out-out ActLoopNT-out 5.263 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 145.74 APE8-dihe-in -60.19, 116.14 APE8-rot-in 302.87 APE67-dihe-in -59.28, -26.44 -61.48, -36.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.864 None None None XRAY 2.15 0.168 0.224 A 323 299 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9l AGC_RPS6KA3-1_HUMAN AGC 2.7e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KA P51812 62 359 740.0 584:401 Type1 Inactive DFGout 12.972 7.703 None DFGAsp-rot-out -70.85, 175.06 -99.81, -5.69 63.83, -56.08 -54.85, -40.91 296.9, 103.08 -90.51, 7.61 in-out in 9.757 Saltbr-out 5.95 HRD-out -115.19, 98.47 -57.55, -41.76 out-out-out SNCooo out-out ActLoopNT-out 4.895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 132.75 APE9-dihe-na 132.11, 175.33 APE8-dihe-in -91.17, 111.44 APE8-rot-in 313.37 APE67-dihe-in -60.35, -22.61 -61.26, -30.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.938 APE9-dist-in 5.828 None None None XRAY 2.55 0.183 0.227 A 330 280 12 0 0 12 [[68, 327], [422, 679]] 2.0 5d9k AGC_RPS6KA3-1_HUMAN AGC 2.9e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KB P51812 62 359 740.0 584:401 Type1 Inactive DFGout 12.94 7.705 None DFGAsp-rot-out -71.4, 176.28 -100.1, -5.4 64.32, -56.06 -52.09, -44.72 291.08, 99.76 -90.94, 9.31 in-none in 9.81 Saltbr-none 999.0 HRD-out -114.53, 98.39 -57.41, -41.87 none-out-out SNCnoo out-out ActLoopNT-out 5.428 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 137.48 APE9-dihe-na 131.93, 176.62 APE8-dihe-in -91.59, 110.99 APE8-rot-in 314.15 APE67-dihe-in -59.51, -22.8 -61.13, -31.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 13.286 APE9-dist-in 5.876 None None None XRAY 2.55 0.183 0.227 B 330 280 11 0 0 11 [[68, 327], [422, 679]] 2.0 5d9k AGC_RPS6KA3-1_HUMAN AGC 2.9e-97 330.8 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA4-1 KS6A4_HUMAN AF-O75676-K1A O75676 25 309 772.0 No_ligand No_ligand Active DFGin 6.598 13.71 BLAminus DFGAsp-rot-in -124.98, -168.39 42.55, 70.55 203.29, 24.06 -80.59, 14.7 297.97, 83.91 -61.19, -20.29 in-in in 8.77 Saltbr-in 2.604 HRD-in -82.76, -47.29 63.76, 4.18 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.03, 161.17 APE9-dihe-na 111.84, 169.32 APE8-dihe-in -72.29, 131.49 APE8-rot-in 292.11 APE67-dihe-in -60.98, -29.84 -59.69, -36.55 APE12-dist-in 8.541 APE11-dist-in 11.517 APE10-dist-in 5.761 APE9-dist-in 3.594 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K1 AGC_RPS6KA4-1_HUMAN AGC 5.9e-92 313.4 1 260 260 178 179 180 182 184 65 85 89 158 160 159 161 220 207 202 201 200 199 198 197 196 116 Ribosomal protein S6 kinase alpha-4
AGC RPS6KA4-1 KS6A4_HUMAN AF-O75676-K3A O75676 25 309 772.0 No_ligand No_ligand Active DFGin 5.878 13.345 BLAminus DFGAsp-rot-in -137.86, 174.13 57.75, 77.02 204.17, -4.77 -80.17, 14.68 304.16, 99.37 -63.32, -16.55 in-in in 8.703 Saltbr-in 2.623 HRD-in -79.41, -52.95 68.65, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.69, 162.48 APE9-dihe-na 107.74, -177.94 APE8-dihe-in -90.07, 132.25 APE8-rot-in 304.86 APE67-dihe-in -59.91, -31.29 -62.41, -36.29 APE12-dist-in 8.34 APE11-dist-in 11.525 APE10-dist-in 5.775 APE9-dist-in 3.898 None None None AF2 -1.0 1.0 1.0 A 285 285 0 0 0 0 [[33, 301], [408, 674]] 2.0 AF-O75676-K3 AGC_RPS6KA4-1_HUMAN AGC 5.9e-92 313.4 1 260 260 178 179 180 182 184 65 85 89 158 160 159 161 220 207 202 201 200 199 198 197 196 116 Ribosomal protein S6 kinase alpha-4
AGC RPS6KA5-1 KS6A5_HUMAN AF-O75582-K1A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.78 13.79 BLAminus DFGAsp-rot-in -122.36, -163.26 38.53, 66.9 205.82, 19.55 -78.09, 17.93 295.37, 82.19 -64.85, -18.18 in-in in 8.796 Saltbr-in 2.625 HRD-in -82.76, -49.06 64.23, 11.02 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 163.8 APE9-dihe-na 113.59, 179.22 APE8-dihe-in -90.62, 126.59 APE8-rot-in 304.99 APE67-dihe-in -61.69, -29.36 -58.71, -34.47 APE12-dist-in 8.406 APE11-dist-in 11.56 APE10-dist-in 5.806 APE9-dist-in 3.557 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K1 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA5-1 KS6A5_HUMAN AF-O75582-K3A O75582 41 326 802.0 No_ligand No_ligand Active DFGin 6.186 13.358 BLAminus DFGAsp-rot-in -132.07, -177.35 48.31, 79.01 206.54, -5.16 -81.08, 17.52 302.26, 93.07 -63.99, -14.82 in-in in 8.702 Saltbr-in 2.577 HRD-in -86.05, -53.15 68.0, 7.54 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.1, 160.71 APE9-dihe-na 110.46, -176.37 APE8-dihe-in -88.86, 131.0 APE8-rot-in 291.71 APE67-dihe-in -59.57, -30.36 -60.19, -36.11 APE12-dist-in 8.116 APE11-dist-in 11.406 APE10-dist-in 5.697 APE9-dist-in 3.59 None None None AF2 -1.0 1.0 1.0 A 286 286 0 0 0 0 [[49, 318], [423, 687]] 2.0 AF-O75582-K3 AGC_RPS6KA5-1_HUMAN AGC 2e-93 318.2 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA5-1 KS6A5_HUMAN 1VZOA O75582 24 345 802.0 No_ligand No_ligand Inactive DFGinter 7.012 10.857 None DFGAsp-rot-out -86.08, 7.16 -135.82, 179.44 269.56, -63.77 -156.19, 30.86 46.84, 81.68 100.81, 7.87 out-out out 18.111 Saltbr-out 19.343 HRD-in -69.35, -43.67 69.6, -31.81 out-out-out SNCooo out-out ActLoopNT-out 10.263 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -83.3, -23.05 APE9-dihe-na -99.28, -166.51 APE8-dihe-in -67.08, 145.98 APE8-rot-out 174.8 APE67-dihe-in -63.46, -19.35 -108.6, 7.57 APE12-dist-in 13.98 APE11-dist-out 18.829 APE10-dist-out 17.834 APE9-dist-out 11.153 S212D None None XRAY 1.8 0.208 0.242 A 355 319 3 0 0 0 [[49, 318], [423, 687]] 2.0 1vzo AGC_RPS6KA5-1_HUMAN AGC 7.3e-93 316.4 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA6-1 KS6A6_HUMAN AF-Q9UK32-K1A Q9UK32 65 338 745.0 No_ligand No_ligand Active DFGin 6.717 14.38 BLAminus DFGAsp-rot-in -122.74, -167.91 42.21, 63.67 203.33, 27.47 -74.28, 13.2 286.97, 79.25 -62.83, -17.84 in-in in 8.957 Saltbr-in 2.617 HRD-in -80.3, -49.99 66.24, 7.44 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.5, 163.94 APE9-dihe-na 113.91, 169.75 APE8-dihe-in -69.91, 129.74 APE8-rot-in 294.78 APE67-dihe-in -61.58, -27.56 -58.44, -40.04 APE12-dist-in 8.319 APE11-dist-in 11.322 APE10-dist-in 5.613 APE9-dist-in 3.564 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K1 AGC_RPS6KA6-1_HUMAN AGC 7.6e-98 332.7 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN AF-Q9UK32-K3A Q9UK32 65 338 745.0 No_ligand No_ligand Active DFGin 6.501 14.102 BLAminus DFGAsp-rot-in -132.27, -175.76 52.2, 64.77 205.05, 14.17 -72.92, 11.15 296.44, 84.22 -64.03, -14.25 in-in in 8.777 Saltbr-in 2.623 HRD-in -81.65, -46.67 67.29, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.4, 164.19 APE9-dihe-na 112.49, 174.41 APE8-dihe-in -75.23, 135.24 APE8-rot-in 295.17 APE67-dihe-in -61.93, -26.66 -66.02, -39.52 APE12-dist-in 8.423 APE11-dist-in 11.441 APE10-dist-in 5.694 APE9-dist-in 3.368 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[73, 330], [426, 683]] 2.0 AF-Q9UK32-K3 AGC_RPS6KA6-1_HUMAN AGC 7.6e-98 332.7 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.984 11.252 None DFGAsp-rot-in -84.57, 1.64 -160.36, 173.95 203.39, -47.2 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.732 APE11-dist-out 15.871 APE10-dist-out 13.504 APE9-dist-in 5.532 None None None XRAY 2.499 0.188 0.233 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.311 None DFGAsp-rot-in -84.74, -2.79 -145.41, 176.89 206.89, -55.71 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.071 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.915 APE11-dist-out 16.086 APE10-dist-out 13.633 APE9-dist-in 5.522 None None None XRAY 2.499 0.188 0.233 B 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.797 10.982 None DFGAsp-rot-in -66.14, -24.76 -146.8, 171.15 184.14, 24.57 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307 269 30 0 0 11 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.269 10.634 None DFGAsp-rot-in -86.41, -10.47 -141.48, -170.45 212.36, -52.29 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.59 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.912 S232E None None XRAY 2.5 0.227 0.24 A 307 283 16 0 0 8 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.738 None DFGAsp-rot-in -79.92, -10.17 -139.49, -179.53 209.54, -48.65 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.845 S232E None None XRAY 2.5 0.227 0.24 B 307 281 18 0 0 10 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.261 10.877 None DFGAsp-rot-in -85.39, -13.66 -143.61, 178.12 202.81, -28.93 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.909 APE11-dist-out 16.247 APE10-dist-out 12.746 APE9-dist-in 5.596 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KB1 KS6B1_HUMAN 4RLPA P23443 85 372 525.0 72B:401 Type1 Inactive DFGin 6.13 13.245 ABAminus DFGAsp-rot-in -108.51, -71.08 -84.78, 124.37 185.51, 5.47 -121.68, 51.98 300.45, 37.52 -105.22, -52.67 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.77, -44.5 76.33, -53.54 none-in-out SNCnio in-out ActLoopNT-in 3.593 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -96.35 APE8-dihe-in -67.86, 138.97 APE8-rot-in 298.2 APE67-dihe-in -61.94, -34.86 -96.61, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 31.433 None None None XRAY 2.79 0.207 0.23 A 288 261 27 0 0 11 [[91, 352]] 1.0 4rlp AGC_RPS6KB1_HUMAN AGC 3e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L3JA P23443 85 375 525.0 5FI:60401 Type1 Inactive DFGin 6.957 14.984 ABAminus DFGAsp-rot-in -135.63, -1.08 -98.35, 100.89 213.11, 44.38 -120.85, -4.41 289.16, 86.77 -115.51, -149.17 in-in in 8.79 Saltbr-in 2.601 HRD-in -66.03, -51.33 68.42, -9.91 in-out-out SNCioo out-out ActLoopNT-out 14.56 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.58, -47.41 APE9-dihe-na -102.14, -165.34 APE8-dihe-in -61.42, 141.56 APE8-rot-out 181.9 APE67-dihe-in -64.17, -15.6 -103.7, 4.9 APE12-dist-in 12.365 APE11-dist-out 14.466 APE10-dist-out 9.751 APE9-dist-out 10.642 None None None XRAY 2.1 0.212 0.255 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3j AGC_RPS6KB1_HUMAN AGC 3.6e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L3LA P23443 85 375 525.0 5FI:60401 Type1 Inactive DFGin 7.001 14.882 ABAminus DFGAsp-rot-in -133.75, -15.34 -92.17, 82.26 182.18, 29.23 -113.96, -4.44 296.95, 94.97 -108.02, -151.72 in-in in 9.02 Saltbr-in 2.698 HRD-in -63.02, -41.25 83.64, -56.35 in-out-out SNCioo out-out ActLoopNT-out 14.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.55, -38.47 APE9-dihe-na -103.09, -167.43 APE8-dihe-in -63.57, 145.34 APE8-rot-out 180.21 APE67-dihe-in -64.07, -18.64 -108.56, 8.72 APE12-dist-in 12.289 APE11-dist-out 14.487 APE10-dist-out 9.846 APE9-dist-out 11.496 None None None XRAY 2.1 0.208 0.247 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3l AGC_RPS6KB1_HUMAN AGC 3.6e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 7N91A P23443 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.745 14.303 ABAminus DFGAsp-rot-out -137.24, 0.52 -126.06, 92.82 291.17, -59.66 -120.47, 16.13 313.15, 88.79 -107.87, -160.91 in-in in 9.435 Saltbr-in 3.535 HRD-in -82.25, -17.04 69.01, -55.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -145.04 APE8-dihe-in -82.16, 156.45 APE8-rot-out 182.85 APE67-dihe-in -47.49, -22.81 -116.45, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.069 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 A 340 307 18 0 0 15 [[91, 352]] 1.0 7n91 AGC_RPS6KB1_HUMAN AGC 5.4e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 7N91B P23443 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.806 14.222 ABAminus DFGAsp-rot-out -123.54, -0.19 -129.03, 100.45 283.53, -43.5 -127.45, 15.05 313.89, 88.27 -106.37, -120.46 in-in in 9.03 Saltbr-in 3.09 HRD-in -90.84, -16.84 59.67, -54.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.82 APE8-rot-out 171.24 APE67-dihe-in -64.35, -34.0 -103.88, 13.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 B 340 313 15 0 0 15 [[91, 352]] 1.0 7n91 AGC_RPS6KB1_HUMAN AGC 5.4e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 7N93A P23443 87 418 525.0 1SK:501 Type1 Inactive DFGin 6.834 14.674 ABAminus DFGAsp-rot-out -126.58, -26.86 -97.15, 99.04 293.02, 42.38 -121.83, -4.26 300.71, 92.82 -113.66, -157.84 in-in in 9.738 Saltbr-in 2.673 HRD-in -101.78, -26.88 75.91, -55.07 in-out-out SNCioo out-out ActLoopNT-out 14.081 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 31.81 APE9-dihe-na 99.46, -176.13 APE8-dihe-in -58.12, 156.59 APE8-rot-out 175.34 APE67-dihe-in -46.11, -19.14 -107.34, -3.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.047 APE9-dist-out 11.464 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 A 340 312 11 0 0 11 [[91, 352]] 1.0 7n93 AGC_RPS6KB1_HUMAN AGC 5.4e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 7N93B P23443 85 418 525.0 1SK:501 Type1 Inactive DFGin 6.843 14.993 ABAminus DFGAsp-rot-out -125.38, -26.14 -102.53, 92.75 284.82, -77.9 -112.09, -9.82 298.31, 100.51 -98.13, -140.14 in-in in 9.44 Saltbr-in 2.932 HRD-in -73.16, -34.65 78.65, -66.66 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.54 APE8-dihe-in -65.27, 128.55 APE8-rot-out 146.5 APE67-dihe-in -69.77, -24.05 -96.24, 7.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.005 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 B 340 309 14 0 0 14 [[91, 352]] 1.0 7n93 AGC_RPS6KB1_HUMAN AGC 5.4e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.117 ABAminus DFGAsp-rot-in -137.83, -32.54 -98.98, 101.69 190.57, -20.68 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.238 Saltbr-in 2.912 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.247 APE11-dist-in 13.136 APE10-dist-out 9.309 APE9-dist-out 11.608 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327 264 24 0 0 10 [[91, 352]] 1.0 3a62 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WE4A P23443 85 374 525.0 5FI:402 Type1 Inactive DFGin 7.02 14.733 ABAminus DFGAsp-rot-in -125.47, -18.75 -95.38, 90.84 179.21, 39.65 -122.57, 0.96 296.46, 95.2 -120.64, -158.24 in-in in 8.983 Saltbr-in 2.795 HRD-in -79.06, -32.34 75.27, -49.87 in-out-out SNCioo out-out ActLoopNT-out 14.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -76.57, -30.69 APE9-dihe-na -111.67, -160.44 APE8-dihe-in -65.24, 142.31 APE8-rot-out 177.96 APE67-dihe-in -64.53, -17.87 -105.62, 6.77 APE12-dist-in 11.776 APE11-dist-out 14.019 APE10-dist-out 9.521 APE9-dist-out 11.659 None TPO252 TPO252 XRAY 1.995 0.177 0.231 A 329 287 3 0 0 3 [[91, 352]] 1.0 3we4 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF5A P23443 85 374 525.0 FZ8:402 Type1 Inactive DFGin 6.865 14.371 ABAminus DFGAsp-rot-in -129.76, -14.65 -92.38, 84.54 188.92, 50.84 -117.05, 2.8 295.94, 106.35 -92.73, -179.05 in-in in 8.554 Saltbr-in 2.776 HRD-in -78.96, -34.1 73.1, -44.42 in-out-out SNCioo out-out ActLoopNT-out 13.995 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.34, -49.41 APE9-dihe-na -98.44, -161.28 APE8-dihe-in -64.31, 143.89 APE8-rot-out 179.68 APE67-dihe-in -62.79, -13.23 -110.77, 8.19 APE12-dist-in 10.641 APE11-dist-in 13.275 APE10-dist-out 9.24 APE9-dist-out 11.479 None TPO252 TPO252 XRAY 2.099 0.177 0.233 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf5 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF6A P23443 85 374 525.0 FZ9:402 Type1 Inactive DFGin 6.703 14.371 ABAminus DFGAsp-rot-in -133.23, -13.75 -102.6, 94.37 182.14, 38.8 -125.05, 0.97 297.43, 101.06 -85.4, -167.64 in-in in 8.67 Saltbr-in 2.712 HRD-in -77.97, -32.15 71.46, -43.57 in-out-out SNCioo out-out ActLoopNT-out 13.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -69.93, -50.15 APE9-dihe-na -98.92, -163.08 APE8-dihe-in -59.61, 143.39 APE8-rot-out 176.13 APE67-dihe-in -64.45, -12.44 -111.84, 9.05 APE12-dist-in 10.459 APE11-dist-in 13.149 APE10-dist-out 9.115 APE9-dist-out 11.592 None TPO252 TPO252 XRAY 2.031 0.198 0.265 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf6 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L45A P23443 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.233 14.636 ABAminus DFGAsp-rot-out -119.27, -13.93 -120.01, 100.8 260.43, -67.35 -106.47, 0.67 296.17, 87.49 -106.81, -133.5 in-in in 8.727 Saltbr-in 2.849 HRD-out -61.14, 153.32 -124.12, -51.0 in-out-out SNCioo out-out ActLoopNT-out 15.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.41 APE8-dihe-in -80.83, 132.8 APE8-rot-in 322.12 APE67-dihe-in -68.02, -0.43 -92.13, -15.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.762 T412E None None XRAY 2.9 0.235 0.286 A 346 317 11 0 0 11 [[91, 352]] 1.0 4l45 AGC_RPS6KB1_HUMAN AGC 5.7e-96 326.7 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L42A P23443 84 417 525.0 5FI:60401 Type1 Inactive DFGin 6.836 14.464 ABAminus DFGAsp-rot-in -94.23, -38.55 -136.54, 108.38 163.85, 45.51 -136.44, 3.89 300.67, 83.7 -99.18, -151.82 in-in in 9.122 Saltbr-in 2.49 HRD-in -62.75, -31.77 73.94, -56.14 in-out-out SNCioo out-out ActLoopNT-out 14.884 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -70.78, -35.44 APE9-dihe-na -101.55, -147.05 APE8-dihe-in -76.25, 145.76 APE8-rot-out 181.86 APE67-dihe-in -41.34, -45.47 -103.54, -6.14 APE12-dist-in 11.561 APE11-dist-in 13.893 APE10-dist-out 9.617 APE9-dist-out 11.006 S403E,A404E,N405Q,Q406E,V407M,L409R,G410D,T412E,V414I,P416D,S417W None None XRAY 2.8 0.23 0.263 A 346 299 0 0 0 0 [[91, 352]] 1.0 4l42 AGC_RPS6KB1_HUMAN AGC 5.7e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L46A P23443 80 417 525.0 5FI:60401 Type1 Inactive DFGin 7.241 14.444 ABAminus DFGAsp-rot-out -128.62, -46.06 -107.19, 113.68 284.23, -43.52 -124.45, -8.59 294.14, 89.1 -97.33, -135.09 in-in in 8.909 Saltbr-in 3.025 HRD-out -53.09, -17.17 51.06, -128.85 in-out-out SNCioo out-out ActLoopNT-out 15.252 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -88.19, -33.47 APE9-dihe-na -130.34, -153.74 APE8-dihe-in -66.16, 132.01 APE8-rot-out 141.11 APE67-dihe-in -64.11, -10.28 -108.34, -0.39 APE12-dist-in 12.109 APE11-dist-out 14.419 APE10-dist-out 9.81 APE9-dist-out 13.005 None TPO412 TPO412 XRAY 3.01 0.22 0.269 A 346 318 4 0 0 4 [[91, 352]] 1.0 4l46 AGC_RPS6KB1_HUMAN AGC 5.7e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN AF-P23443-K1A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.85 14.148 BLAminus DFGAsp-rot-in -124.31, -166.39 38.73, 66.43 205.1, 24.77 -77.66, 13.72 288.38, 76.88 -63.66, -21.1 in-in in 8.764 Saltbr-in 2.612 HRD-in -85.2, -47.45 63.14, 5.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.51, 166.53 APE9-dihe-na 111.13, -177.37 APE8-dihe-in -97.94, 129.35 APE8-rot-in 304.6 APE67-dihe-in -59.86, -23.05 -60.69, -41.68 APE12-dist-in 8.424 APE11-dist-in 11.405 APE10-dist-in 5.675 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K1 AGC_RPS6KB1_HUMAN AGC 2.6e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN AF-P23443-K3A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.499 13.931 BLAminus DFGAsp-rot-in -128.06, -173.88 44.57, 66.94 206.78, 17.91 -75.34, 10.89 293.5, 80.29 -60.23, -27.79 in-in in 8.905 Saltbr-in 2.613 HRD-in -82.97, -50.48 68.32, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 169.69 APE9-dihe-na 107.2, 177.16 APE8-dihe-in -89.35, 135.4 APE8-rot-in 302.12 APE67-dihe-in -65.67, -26.41 -68.11, -34.82 APE12-dist-in 8.273 APE11-dist-in 11.346 APE10-dist-in 5.632 APE9-dist-in 3.355 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K3 AGC_RPS6KB1_HUMAN AGC 2.6e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF8A P23443 85 372 525.0 F76:402 Type1 Inactive DFGin 7.102 14.978 BLAminus DFGAsp-rot-in -129.9, -170.63 61.17, 70.04 187.49, 42.74 -107.71, -0.62 293.51, 88.63 -118.48, -145.57 in-in in 9.295 Saltbr-in 2.652 HRD-in -77.55, -44.17 68.12, -42.54 in-out-out SNCioo out-out ActLoopNT-out 14.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.25, -35.51 APE9-dihe-na -76.92, -168.9 APE8-dihe-in -54.62, 141.74 APE8-rot-out 169.07 APE67-dihe-in -59.06, -20.42 -107.38, 7.1 APE12-dist-in 10.871 APE11-dist-in 13.619 APE10-dist-out 9.628 APE9-dist-out 10.039 None TPO252 TPO252 XRAY 1.975 0.203 0.241 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf8 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF9A P23443 85 372 525.0 FS7:402 Type1 Inactive DFGin 7.076 14.804 BLAminus DFGAsp-rot-in -128.9, -172.38 62.02, 66.77 194.27, 24.61 -105.26, 3.14 300.18, 93.35 -120.0, -148.85 in-in in 9.088 Saltbr-in 2.718 HRD-in -75.59, -53.56 73.09, -41.71 in-out-out SNCioo out-out ActLoopNT-out 14.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -64.84, -25.92 APE9-dihe-na -80.51, -169.69 APE8-dihe-in -58.81, 141.58 APE8-rot-out 172.69 APE67-dihe-in -64.9, -25.53 -106.39, 16.05 APE12-dist-in 10.888 APE11-dist-in 13.536 APE10-dist-out 9.666 APE9-dist-out 9.704 None TPO252 TPO252 XRAY 2.035 0.217 0.265 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf9 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L43A P23443 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.503 14.59 BLAminus DFGAsp-rot-out -152.19, 178.7 68.2, 63.89 262.77, -10.36 -95.2, 1.23 292.21, 97.05 -112.42, -123.66 in-in in 9.238 Saltbr-in 3.303 HRD-in -82.62, -11.83 59.52, -90.37 in-out-out SNCioo out-out ActLoopNT-out 16.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -80.85 APE8-dihe-in -75.2, 157.68 APE8-rot-in 319.39 APE67-dihe-in -73.24, -5.47 -122.38, -12.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.069 T412A None None XRAY 3.0 0.229 0.279 A 346 316 11 0 0 11 [[91, 352]] 1.0 4l43 AGC_RPS6KB1_HUMAN AGC 5.7e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4L44A P23443 81 417 525.0 5FI:60404 Type1 Inactive DFGin 7.589 14.631 BLAminus DFGAsp-rot-out -133.78, 179.09 58.09, 63.64 260.61, 4.22 -94.03, 8.12 300.2, 94.56 -89.28, -144.2 in-in in 9.078 Saltbr-in 2.827 HRD-in -51.83, -35.36 73.61, -57.08 in-out-out SNCioo out-out ActLoopNT-out 14.948 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -91.08, 128.5 APE9-dihe-na 94.25, -75.66 APE8-dihe-in -159.56, 138.01 APE8-rot-out 142.19 APE67-dihe-in -66.44, -10.43 -117.84, -6.33 APE12-dist-in 12.107 APE11-dist-out 14.059 APE10-dist-out 9.638 APE9-dist-out 12.9 T412A None None XRAY 2.9 0.246 0.298 A 346 321 5 0 0 5 [[91, 352]] 1.0 4l44 AGC_RPS6KB1_HUMAN AGC 5.7e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOA P23443 85 371 525.0 3T3:401 Type1 Inactive DFGin 5.27 12.747 None DFGAsp-rot-in -131.54, -63.42 -88.2, 143.06 192.77, -18.69 -127.47, 172.78 303.39, 172.08 126.01, -46.31 in-in in 7.698 Saltbr-in 2.3 HRD-in -57.89, -55.64 79.38, -25.61 in-in-out SNCiio in-out ActLoopNT-in 3.286 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.78 APE8-dihe-in -54.68, 162.27 APE8-rot-out 190.34 APE67-dihe-in -62.73, -12.73 -141.73, -3.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 30.222 None None None XRAY 2.527 0.193 0.222 A 288 259 28 0 0 12 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 3e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.157 13.694 None DFGAsp-rot-in -106.91, -67.93 -78.35, 124.27 192.49, 16.9 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.754 Saltbr-out 3.905 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327 263 24 0 0 13 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.812 13.405 None DFGAsp-rot-in -134.05, -75.4 -81.48, 111.28 185.17, 1.75 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.863 Saltbr-in 3.459 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.963 None None None XRAY 3.43 0.274 0.349 A 327 254 31 0 0 16 [[91, 352]] 1.0 3a61 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3WF7A P23443 83 374 525.0 FS9:402 Type1 Inactive DFGin 6.662 14.99 None DFGAsp-rot-in -128.93, -10.26 -99.96, 98.47 186.97, 48.24 -129.8, 160.96 298.66, 90.56 73.54, -129.51 out-out out 14.17 Saltbr-out 10.14 HRD-in -80.11, -34.14 77.1, -48.65 out-out-out SNCooo out-out ActLoopNT-out 12.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.88, 130.47 APE9-dihe-na 74.33, -175.83 APE8-dihe-in -68.5, 140.34 APE8-rot-out 182.72 APE67-dihe-in -64.92, -16.71 -105.43, 9.18 APE12-dist-in 11.961 APE11-dist-out 14.438 APE10-dist-out 10.015 APE9-dist-out 11.986 None TPO252 TPO252 XRAY 1.85 0.175 0.224 A 329 289 3 0 0 3 [[91, 352]] 1.0 3wf7 AGC_RPS6KB1_HUMAN AGC 4.8e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.196 None DFGAsp-rot-out -86.75, 160.35 -107.62, 22.98 70.35, -11.58 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288 254 34 0 0 11 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 3e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB1 KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.181 None DFGAsp-rot-out -122.3, -155.7 -144.9, 63.43 272.21, 54.17 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.777 APE9-dist-out 31.967 None None None XRAY 2.8 0.21 0.268 B 327 255 33 0 0 10 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AGC RPS6KB2 KS6B2_HUMAN AF-Q9UBS0-K1A Q9UBS0 59 336 482.0 No_ligand No_ligand Active DFGin 6.767 14.153 BLAminus DFGAsp-rot-in -122.6, -163.21 32.52, 70.94 205.93, 17.73 -79.17, 14.37 282.5, 73.29 -66.4, -18.33 in-in in 9.058 Saltbr-in 2.658 HRD-in -85.1, -48.99 62.91, 8.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.67, 166.83 APE9-dihe-na 112.36, -178.82 APE8-dihe-in -94.75, 128.18 APE8-rot-in 304.35 APE67-dihe-in -60.99, -23.51 -55.81, -43.33 APE12-dist-in 8.296 APE11-dist-in 11.418 APE10-dist-in 5.72 APE9-dist-in 3.404 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[67, 328]] 1.0 AF-Q9UBS0-K1 AGC_RPS6KB2_HUMAN AGC 2.1e-95 324.7 1 260 260 211 212 213 215 217 99 119 123 191 193 192 194 251 239 234 233 232 231 230 229 228 149 Ribosomal protein S6 kinase beta-2
AGC RPS6KB2 KS6B2_HUMAN AF-Q9UBS0-K3A Q9UBS0 59 336 482.0 No_ligand No_ligand Active DFGin 6.562 13.94 BLAminus DFGAsp-rot-in -128.82, -176.09 45.46, 64.71 207.48, 19.07 -72.89, 13.46 297.09, 86.74 -63.72, -26.05 in-in in 8.846 Saltbr-in 2.62 HRD-in -82.85, -49.48 67.58, 9.22 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.3, 167.26 APE9-dihe-na 111.46, 179.11 APE8-dihe-in -88.78, 132.69 APE8-rot-in 290.07 APE67-dihe-in -60.12, -23.72 -65.21, -38.72 APE12-dist-in 8.179 APE11-dist-in 11.341 APE10-dist-in 5.623 APE9-dist-in 3.377 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[67, 328]] 1.0 AF-Q9UBS0-K3 AGC_RPS6KB2_HUMAN AGC 2.1e-95 324.7 1 260 260 211 212 213 215 217 99 119 123 191 193 192 194 251 239 234 233 232 231 230 229 228 149 Ribosomal protein S6 kinase beta-2
AGC RSKR KS6R_HUMAN AF-Q96LW2-K1A Q96LW2 99 367 410.0 No_ligand No_ligand Active DFGin 6.001 14.413 BLAminus DFGAsp-rot-in -128.15, 175.11 63.05, 70.74 203.01, 9.58 -77.02, 14.42 296.82, 82.95 -59.41, -30.24 in-in in 9.187 Saltbr-in 2.761 HRD-in -72.59, -46.98 65.7, 9.25 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.27, 158.07 APE9-dihe-na 116.39, -173.48 APE8-dihe-in -88.12, 124.34 APE8-rot-in 302.8 APE67-dihe-in -69.33, -19.53 -47.96, -47.56 APE12-dist-in 9.264 APE11-dist-in 11.918 APE10-dist-in 6.183 APE9-dist-in 3.33 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[107, 359]] 1.0 AF-Q96LW2-K1 AGC_RSKR_HUMAN AGC 2.7e-69 239.1 2 260 259 246 247 248 250 252 136 155 159 226 228 227 229 285 273 268 267 266 265 264 263 262 185 Ribosomal protein S6 kinase-related protein
AGC RSKR KS6R_HUMAN AF-Q96LW2-K3A Q96LW2 99 367 410.0 No_ligand No_ligand Active DFGin 6.015 14.381 BLAminus DFGAsp-rot-in -130.08, -176.68 56.94, 61.03 206.75, 13.39 -66.7, 14.64 294.77, 81.62 -63.54, -22.02 in-in in 9.311 Saltbr-in 2.759 HRD-in -79.07, -48.39 69.1, 3.8 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.04, 159.89 APE9-dihe-na 119.8, -171.41 APE8-dihe-in -96.32, 125.52 APE8-rot-in 302.07 APE67-dihe-in -64.39, -22.74 -47.43, -45.47 APE12-dist-in 8.888 APE11-dist-in 11.657 APE10-dist-in 5.981 APE9-dist-in 3.373 None None None AF2 -1.0 1.0 1.0 A 269 269 0 0 0 0 [[107, 359]] 1.0 AF-Q96LW2-K3 AGC_RSKR_HUMAN AGC 2.7e-69 239.1 2 260 259 246 247 248 250 252 136 155 159 226 228 227 229 285 273 268 267 266 265 264 263 262 185 Ribosomal protein S6 kinase-related protein
AGC SGK1 SGK1_HUMAN AF-O00141-K1A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.581 13.124 BLAminus DFGAsp-rot-in -124.65, -166.79 42.56, 64.43 203.37, 17.06 -73.44, 18.78 305.22, 97.86 -59.66, -29.15 in-in in 8.643 Saltbr-in 2.619 HRD-in -74.89, -49.13 66.3, -0.59 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.35, 160.2 APE9-dihe-na 121.68, 167.97 APE8-dihe-in -78.59, 129.41 APE8-rot-in 299.24 APE67-dihe-in -64.62, -22.89 -47.15, -41.83 APE12-dist-in 8.396 APE11-dist-in 11.598 APE10-dist-in 5.867 APE9-dist-in 3.664 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-O00141-K1 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN AF-O00141-K3A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.302 13.205 BLAminus DFGAsp-rot-in -132.91, -176.65 51.85, 63.47 207.46, 14.71 -69.17, 14.1 303.31, 90.06 -64.44, -24.17 in-in in 8.874 Saltbr-in 2.646 HRD-in -80.08, -49.64 66.81, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.31, 163.89 APE9-dihe-na 116.3, 167.63 APE8-dihe-in -77.55, 132.12 APE8-rot-in 281.34 APE67-dihe-in -64.39, -24.37 -47.8, -41.95 APE12-dist-in 8.43 APE11-dist-in 11.586 APE10-dist-in 5.913 APE9-dist-in 3.428 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[98, 355]] 1.0 AF-O00141-K3 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.249 5.74 None DFGAsp-rot-in -86.79, -16.14 -72.2, 135.26 187.88, -80.22 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.883 APE11-dist-out 30.65 APE10-dist-out 28.034 APE9-dist-out 16.248 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373 284 13 0 0 0 [[98, 355]] 1.0 2r5t AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDMA O00141 81 378 431.0 MMG:500 Type1 Inactive DFGinter 9.977 5.743 None DFGAsp-rot-in -83.68, -7.68 -69.69, 128.31 171.02, 79.94 -122.03, 7.18 59.85, 94.45 118.71, -0.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.93, -38.18 84.66, -53.42 none-out-out SNCnoo out-out ActLoopNT-out 7.78 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.48, 64.87 APE9-dihe-na -77.63, -170.21 APE8-dihe-in -69.51, 134.86 APE8-rot-in 310.86 APE67-dihe-out -140.61, 157.94 -65.57, 107.15 APE12-dist-out 30.439 APE11-dist-out 31.121 APE10-dist-out 28.385 APE9-dist-out 16.422 S74A,S78A,S397A,S401A None None XRAY 2.6 0.22 0.262 A 373 285 13 0 0 0 [[98, 355]] 1.0 3hdm AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDNA O00141 82 374 431.0 GMG:1 Type1 Inactive DFGinter 10.684 6.059 None DFGAsp-rot-in -80.54, -17.07 -64.88, 127.58 192.2, -65.6 -123.29, -5.01 55.66, 91.25 125.69, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.11, -29.45 73.47, -60.84 none-out-out SNCnoo out-out ActLoopNT-out 8.284 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.04, 66.32 APE9-dihe-na -71.14, 173.43 APE8-dihe-in -68.52, 127.58 APE8-rot-in 307.02 APE67-dihe-out -159.22, 150.57 -56.04, 117.71 APE12-dist-out 30.099 APE11-dist-out 30.865 APE10-dist-out 28.034 APE9-dist-out 16.482 S74A,S78A,S397A,S401A None None XRAY 3.1 0.251 0.278 A 373 280 13 0 0 0 [[98, 355]] 1.0 3hdn AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 7PUEA O00141 82 376 431.0 86H:503 Type1 Inactive DFGout 13.845 12.456 None DFGAsp-rot-out -128.32, 161.54 66.3, 44.42 250.25, -39.6 -96.18, 38.15 38.7, 87.51 60.24, 26.6 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.9, -50.5 67.78, -47.28 none-out-out SNCnoo out-out ActLoopNT-out 10.154 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 61.89, -99.42 APE9-dihe-na 71.22, 134.57 APE8-dihe-in -55.98, 129.77 APE8-rot-out 64.18 APE67-dihe-out -107.13, 123.21 -48.22, 142.9 APE12-dist-out 34.281 APE11-dist-out 33.533 APE10-dist-out 29.714 APE9-dist-out 16.9 R192A,S422D None None XRAY 2.506 0.216 0.249 A 375 271 24 0 0 8 [[98, 355]] 1.0 7pue AGC_SGK1_HUMAN AGC 7.4e-99 336.1 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK2 SGK2_HUMAN AF-Q9HBY8-K1A Q9HBY8 27 300 367.0 No_ligand No_ligand Active DFGin 6.757 13.183 BLAminus DFGAsp-rot-in -126.19, -164.1 40.86, 62.15 206.42, 19.58 -71.83, 20.65 305.11, 102.31 -61.65, -30.88 in-in in 8.474 Saltbr-in 2.632 HRD-in -81.71, -47.54 64.15, 1.17 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.38, 158.67 APE9-dihe-na 125.17, 168.37 APE8-dihe-in -80.06, 129.55 APE8-rot-in 299.85 APE67-dihe-in -63.96, -21.91 -47.78, -42.81 APE12-dist-in 8.307 APE11-dist-in 11.589 APE10-dist-in 5.847 APE9-dist-in 3.631 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[35, 292]] 1.0 AF-Q9HBY8-K1 AGC_SGK2_HUMAN AGC 5.4e-97 329.9 1 260 260 176 177 178 180 182 64 83 87 156 158 157 159 216 204 199 198 197 196 195 194 193 114 Serine/threonine-protein kinase Sgk2
AGC SGK2 SGK2_HUMAN AF-Q9HBY8-K3A Q9HBY8 27 300 367.0 No_ligand No_ligand Active DFGin 6.008 12.725 BLAminus DFGAsp-rot-in -136.14, -177.62 55.87, 64.97 206.14, 11.23 -72.87, 17.08 309.8, 105.75 -66.38, -25.27 in-in in 8.572 Saltbr-in 2.609 HRD-in -79.56, -49.81 67.65, 8.61 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.72, 160.21 APE9-dihe-na 128.5, 178.27 APE8-dihe-in -92.21, 130.85 APE8-rot-in 293.37 APE67-dihe-in -64.53, -22.85 -47.18, -44.94 APE12-dist-in 8.561 APE11-dist-in 11.589 APE10-dist-in 5.894 APE9-dist-in 3.38 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[35, 292]] 1.0 AF-Q9HBY8-K3 AGC_SGK2_HUMAN AGC 5.4e-97 329.9 1 260 260 176 177 178 180 182 64 83 87 156 158 157 159 216 204 199 198 197 196 195 194 193 114 Serine/threonine-protein kinase Sgk2
AGC SGK3 SGK3_HUMAN AF-Q96BR1-K1A Q96BR1 154 427 496.0 No_ligand No_ligand Active DFGin 6.554 13.233 BLAminus DFGAsp-rot-in -124.26, -164.17 39.89, 62.61 205.91, 18.14 -70.98, 20.78 304.51, 99.52 -61.78, -29.79 in-in in 8.749 Saltbr-in 2.617 HRD-in -76.68, -49.81 63.69, 3.76 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.42, 161.15 APE9-dihe-na 124.64, 167.92 APE8-dihe-in -81.48, 130.81 APE8-rot-in 298.9 APE67-dihe-in -65.23, -22.01 -49.05, -42.13 APE12-dist-in 8.372 APE11-dist-in 11.657 APE10-dist-in 5.911 APE9-dist-in 3.584 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[162, 419]] 1.0 AF-Q96BR1-K1 AGC_SGK3_HUMAN AGC 1.6e-96 328.4 1 260 260 303 304 305 307 309 191 210 214 283 285 284 286 343 331 326 325 324 323 322 321 320 241 Serine/threonine-protein kinase Sgk3
AGC SGK3 SGK3_HUMAN AF-Q96BR1-K3A Q96BR1 154 427 496.0 No_ligand No_ligand Active DFGin 6.057 12.929 BLAminus DFGAsp-rot-in -127.24, -166.5 45.66, 62.91 206.92, 17.28 -70.24, 20.11 307.22, 99.55 -62.39, -28.8 in-in in 8.846 Saltbr-in 2.67 HRD-in -78.27, -50.26 68.22, 4.19 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.59, 166.93 APE9-dihe-na 122.01, -178.74 APE8-dihe-in -96.73, 130.87 APE8-rot-in 294.73 APE67-dihe-in -66.48, -22.51 -48.92, -42.34 APE12-dist-in 8.575 APE11-dist-in 11.523 APE10-dist-in 5.886 APE9-dist-in 3.513 None None None AF2 -1.0 1.0 1.0 A 274 274 0 0 0 0 [[162, 419]] 1.0 AF-Q96BR1-K3 AGC_SGK3_HUMAN AGC 1.6e-96 328.4 1 260 260 303 304 305 307 309 191 210 214 283 285 284 286 343 331 326 325 324 323 322 321 320 241 Serine/threonine-protein kinase Sgk3
AGC STK32A ST32A_HUMAN AF-Q8WU08-K1A Q8WU08 15 289 396.0 No_ligand No_ligand Active DFGin 6.691 14.98 BLAminus DFGAsp-rot-in -134.52, 176.14 62.68, 72.52 194.49, 9.22 -81.94, 13.61 288.18, 84.89 -57.12, -36.56 in-in in 9.737 Saltbr-in 2.732 HRD-in -76.02, -47.46 67.94, -2.78 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.29, 143.95 APE9-dihe-na 133.56, 174.14 APE8-dihe-in -86.99, 107.05 APE8-rot-in 307.27 APE67-dihe-in -67.4, -14.96 -36.72, -45.57 APE12-dist-in 9.919 APE11-dist-in 11.672 APE10-dist-in 5.831 APE9-dist-in 3.353 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[23, 281]] 1.0 AF-Q8WU08-K1 AGC_STK32A_HUMAN AGC 2.6e-84 288.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN AF-Q8WU08-K3A Q8WU08 15 289 396.0 No_ligand No_ligand Active DFGin 6.205 14.899 BLAminus DFGAsp-rot-in -134.69, 175.4 63.51, 72.19 199.57, 13.11 -77.61, 13.96 291.45, 89.04 -57.55, -31.55 in-in in 9.385 Saltbr-in 2.755 HRD-in -71.4, -43.65 68.44, -0.86 in-in-in SNCiii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.44, 147.52 APE9-dihe-na 129.41, -176.11 APE8-dihe-in -96.11, 105.57 APE8-rot-in 302.12 APE67-dihe-in -61.84, -14.72 -39.2, -44.55 APE12-dist-in 9.655 APE11-dist-in 11.314 APE10-dist-in 5.491 APE9-dist-in 3.189 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[23, 281]] 1.0 AF-Q8WU08-K3 AGC_STK32A_HUMAN AGC 2.6e-84 288.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4A Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.958 14.55 BLAminus DFGAsp-rot-in -131.26, -171.36 55.81, 77.24 197.42, 5.79 -91.39, 23.54 282.26, 68.76 -52.72, -37.5 in-out in 9.45 Saltbr-out 4.405 HRD-in -80.59, -48.19 75.72, 1.95 out-in-in SNCoii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 125.66 APE9-dihe-na 163.36, -179.6 APE8-dihe-in -98.31, 118.28 APE8-rot-in 302.74 APE67-dihe-in -69.16, -7.09 -58.36, -42.03 APE12-dist-in 9.984 APE11-dist-in 11.7 APE10-dist-in 6.037 APE9-dist-in 3.577 None None None XRAY 2.29 0.206 0.244 A 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4B Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 7.004 14.665 BLAminus DFGAsp-rot-in -130.94, -173.3 57.57, 78.46 194.44, -1.48 -91.73, 35.47 281.68, 71.64 -62.72, -37.53 in-out in 9.523 Saltbr-out 4.678 HRD-in -83.22, -47.99 75.33, -2.43 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.47, 130.4 APE9-dihe-na 159.4, 177.51 APE8-dihe-in -93.68, 119.81 APE8-rot-in 304.76 APE67-dihe-in -71.88, -7.25 -60.98, -38.06 APE12-dist-in 10.024 APE11-dist-in 11.735 APE10-dist-in 6.019 APE9-dist-in 3.57 None None None XRAY 2.29 0.206 0.244 B 384 350 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4C Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.95 14.697 BLAminus DFGAsp-rot-in -132.52, -169.93 52.69, 78.95 196.55, 4.33 -90.58, 33.35 282.07, 69.09 -66.67, -30.48 in-out in 9.538 Saltbr-out 4.652 HRD-in -81.16, -46.81 73.79, 0.59 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.08, 126.04 APE9-dihe-na 163.32, 177.32 APE8-dihe-in -92.37, 117.65 APE8-rot-in 306.61 APE67-dihe-in -71.09, -9.62 -57.49, -40.3 APE12-dist-in 9.986 APE11-dist-in 11.719 APE10-dist-in 6.031 APE9-dist-in 3.569 None None None XRAY 2.29 0.206 0.244 C 384 344 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4D Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.968 14.54 BLAminus DFGAsp-rot-in -131.99, -171.7 54.78, 77.72 198.43, 8.8 -90.01, 30.97 282.82, 68.36 -59.09, -35.1 in-out in 9.54 Saltbr-out 4.111 HRD-in -82.23, -46.79 74.71, 0.05 out-in-in SNCoii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 126.06 APE9-dihe-na 163.38, 179.82 APE8-dihe-in -95.08, 119.14 APE8-rot-in 303.5 APE67-dihe-in -68.68, -8.82 -58.5, -42.47 APE12-dist-in 10.028 APE11-dist-in 11.674 APE10-dist-in 5.978 APE9-dist-in 3.621 None None None XRAY 2.29 0.206 0.244 D 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4E Q8WU08 14 372 396.0 STU:401 Type1 Inactive DFGin 6.929 14.69 BLAminus DFGAsp-rot-in -131.82, -175.27 57.96, 79.76 196.84, 0.18 -93.48, 35.37 282.42, 66.15 -67.02, -30.68 in-out in 9.559 Saltbr-out 4.667 HRD-in -80.84, -48.94 74.6, -0.56 out-in-in SNCoii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.84, 126.86 APE9-dihe-na 161.76, 179.6 APE8-dihe-in -94.71, 118.0 APE8-rot-in 302.52 APE67-dihe-in -65.82, -9.98 -56.35, -43.97 APE12-dist-in 10.033 APE11-dist-in 11.753 APE10-dist-in 6.011 APE9-dist-in 3.555 None None None XRAY 2.29 0.206 0.244 E 384 342 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32A ST32A_HUMAN 4FR4F Q8WU08 14 373 396.0 STU:401 Type1 Inactive DFGin 6.922 14.48 BLAminus DFGAsp-rot-in -133.24, -172.46 54.73, 79.35 198.93, 0.43 -94.14, 35.98 283.65, 67.48 -61.74, -33.87 in-out in 9.458 Saltbr-out 4.459 HRD-in -80.63, -46.14 70.35, 4.86 out-in-in SNCoii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.84, 129.22 APE9-dihe-na 160.43, 179.28 APE8-dihe-in -96.01, 118.11 APE8-rot-in 307.21 APE67-dihe-in -68.52, -8.52 -57.81, -41.21 APE12-dist-in 10.007 APE11-dist-in 11.703 APE10-dist-in 5.986 APE9-dist-in 3.587 None None None XRAY 2.29 0.206 0.244 F 384 346 0 0 0 0 [[23, 281]] 1.0 4fr4 AGC_STK32A_HUMAN AGC 8e-84 287.1 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 205 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32A
AGC STK32B ST32B_HUMAN AF-Q9NY57-K1A Q9NY57 15 291 414.0 No_ligand No_ligand Active DFGin 6.389 14.494 BLAminus DFGAsp-rot-in -131.15, 175.38 60.66, 77.05 197.98, 24.58 -86.03, 14.25 289.41, 82.97 -54.59, -32.73 in-in in 9.412 Saltbr-in 2.665 HRD-in -72.16, -47.9 68.07, 0.25 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.39, 143.77 APE9-dihe-na 122.75, 173.75 APE8-dihe-in -83.96, 113.15 APE8-rot-in 305.79 APE67-dihe-in -68.57, -13.85 -36.75, -46.17 APE12-dist-in 8.799 APE11-dist-in 11.28 APE10-dist-in 5.446 APE9-dist-in 3.289 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[23, 283]] 1.0 AF-Q9NY57-K1 AGC_STK32B_HUMAN AGC 6.8e-82 280.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 207 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32B
AGC STK32B ST32B_HUMAN AF-Q9NY57-K3A Q9NY57 15 291 414.0 No_ligand No_ligand Active DFGin 6.106 14.902 BLAminus DFGAsp-rot-in -134.32, 176.3 62.98, 74.94 200.62, 9.45 -81.48, 14.43 292.36, 87.95 -58.47, -30.42 in-in in 9.309 Saltbr-in 2.809 HRD-in -72.82, -43.64 70.33, -0.26 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.35, 141.75 APE9-dihe-na 128.67, -173.61 APE8-dihe-in -100.23, 110.09 APE8-rot-in 305.19 APE67-dihe-in -65.55, -13.75 -38.89, -45.84 APE12-dist-in 9.023 APE11-dist-in 11.276 APE10-dist-in 5.378 APE9-dist-in 3.285 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[23, 283]] 1.0 AF-Q9NY57-K3 AGC_STK32B_HUMAN AGC 6.8e-82 280.4 1 259 259 163 164 165 167 169 52 71 75 143 145 144 146 207 190 185 184 183 182 181 180 179 101 Serine/threonine-protein kinase 32B
AGC STK32C ST32C_HUMAN AF-Q86UX6-K1A Q86UX6 85 361 486.0 No_ligand No_ligand Inactive DFGin 7.013 14.776 BLAminus DFGAsp-rot-out -134.49, 176.45 60.2, 74.04 277.72, -22.16 -85.71, 12.13 286.54, 80.85 -59.41, -31.15 in-in in 9.105 Saltbr-in 2.718 HRD-in -73.71, -44.09 65.98, 5.16 in-in-out SNCiio in-out ActLoopNT-in 2.852 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -135.73, 144.96 APE9-dihe-na 124.38, 165.52 APE8-dihe-in -91.66, 123.56 APE8-rot-in 304.0 APE67-dihe-out -108.76, 19.57 -64.68, 130.17 APE12-dist-in 8.966 APE11-dist-in 11.588 APE10-dist-in 5.827 APE9-dist-in 3.207 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[93, 353]] 1.0 AF-Q86UX6-K1 AGC_STK32C_HUMAN AGC 4e-82 281.2 1 258 258 233 234 235 237 239 122 141 145 213 215 214 216 277 260 255 254 253 252 251 250 249 171 Serine/threonine-protein kinase 32C
AGC STK32C ST32C_HUMAN AF-Q86UX6-K3A Q86UX6 85 361 486.0 No_ligand No_ligand Active DFGin 6.618 14.728 BLAminus DFGAsp-rot-in -140.78, 178.78 62.47, 74.47 198.96, 8.69 -81.32, 15.05 293.91, 85.17 -58.16, -28.82 in-in in 9.129 Saltbr-in 2.666 HRD-in -73.3, -43.21 68.03, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 142.63 APE9-dihe-na 125.48, -179.79 APE8-dihe-in -94.87, 111.14 APE8-rot-in 302.22 APE67-dihe-in -64.85, -15.99 -40.84, -43.79 APE12-dist-in 9.122 APE11-dist-in 11.355 APE10-dist-in 5.582 APE9-dist-in 3.184 None None None AF2 -1.0 1.0 1.0 A 277 277 0 0 0 0 [[93, 353]] 1.0 AF-Q86UX6-K3 AGC_STK32C_HUMAN AGC 4e-82 281.2 1 258 258 233 234 235 237 239 122 141 145 213 215 214 216 277 260 255 254 253 252 251 250 249 171 Serine/threonine-protein kinase 32C
AGC STK38 STK38_HUMAN AF-Q15208-K1A Q15208 81 390 465.0 No_ligand No_ligand Active DFGin 6.259 13.072 BLAminus DFGAsp-rot-in -134.61, 173.44 54.06, 73.9 200.68, 16.13 -81.72, 14.99 305.51, 100.34 -63.52, -18.16 in-in in 8.716 Saltbr-in 2.595 HRD-in -72.89, -52.36 66.95, 13.5 in-in-in SNCiii in-in ActLoopNT-in 3.005 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.32, 156.98 APE9-dihe-na 128.63, -175.74 APE8-dihe-in -93.85, 123.58 APE8-rot-in 301.4 APE67-dihe-in -70.52, -20.09 -45.54, -41.13 APE12-dist-in 8.669 APE11-dist-in 11.616 APE10-dist-in 5.73 APE9-dist-in 3.329 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[89, 382]] 1.0 AF-Q15208-K1 AGC_STK38_HUMAN AGC 2.2e-98 334.5 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN AF-Q15208-K3A Q15208 81 390 465.0 No_ligand No_ligand Active DFGin 6.274 12.898 BLAminus DFGAsp-rot-in -140.2, -177.63 50.78, 63.8 200.25, 16.32 -70.85, 11.95 306.06, 111.32 -64.39, -16.5 in-in in 8.668 Saltbr-in 2.613 HRD-in -73.09, -52.84 69.33, 0.49 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 152.58 APE9-dihe-na 134.45, 168.77 APE8-dihe-in -78.44, 129.3 APE8-rot-in 298.45 APE67-dihe-in -74.77, -20.02 -52.75, -38.1 APE12-dist-in 8.716 APE11-dist-in 11.62 APE10-dist-in 5.739 APE9-dist-in 3.208 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[89, 382]] 1.0 AF-Q15208-K3 AGC_STK38_HUMAN AGC 2.2e-98 334.5 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.624 15.242 None DFGAsp-rot-in -66.11, 165.54 -58.06, 132.91 181.03, 64.96 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.224 Saltbr-out 15.803 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.463 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.338 APE11-dist-out 14.208 APE10-dist-out 17.77 APE9-dist-out 12.101 None None None XRAY 2.2 0.173 0.212 A 333 333 0 0 0 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.9e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.583 15.179 None DFGAsp-rot-in -72.08, 165.13 -53.35, 130.13 163.91, 75.08 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.166 Saltbr-out 16.064 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.488 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.239 APE11-dist-out 14.184 APE10-dist-out 17.741 APE9-dist-out 12.052 None None None XRAY 2.2 0.173 0.212 B 333 332 0 0 0 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.9e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38L ST38L_HUMAN AF-Q9Y2H1-K1A Q9Y2H1 82 391 464.0 No_ligand No_ligand Active DFGin 6.127 12.786 BLAminus DFGAsp-rot-in -135.9, 176.29 54.59, 71.07 200.8, 18.54 -77.78, 12.55 308.68, 110.86 -65.47, -15.43 in-in in 8.748 Saltbr-in 2.662 HRD-in -74.57, -52.73 67.15, 13.99 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.54, 159.2 APE9-dihe-na 119.39, -179.63 APE8-dihe-in -97.35, 134.6 APE8-rot-in 300.97 APE67-dihe-in -77.2, -21.12 -50.84, -38.72 APE12-dist-in 8.643 APE11-dist-in 11.648 APE10-dist-in 5.779 APE9-dist-in 3.322 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[90, 383]] 1.0 AF-Q9Y2H1-K1 AGC_STK38L_HUMAN AGC 3.7e-100 340.3 1 260 260 230 231 232 234 236 119 138 142 210 212 211 213 305 293 288 287 286 285 284 283 282 168 Serine/threonine-protein kinase 38-like
AGC STK38L ST38L_HUMAN AF-Q9Y2H1-K3A Q9Y2H1 82 391 464.0 No_ligand No_ligand Active DFGin 6.169 13.097 BLAminus DFGAsp-rot-in -140.06, -179.59 52.1, 63.03 202.52, 14.63 -72.36, 13.02 306.88, 105.07 -64.09, -17.83 in-in in 8.911 Saltbr-in 2.671 HRD-in -72.91, -53.66 69.03, 2.42 in-in-in SNCiii in-in ActLoopNT-in 3.018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.96, 156.91 APE9-dihe-na 124.62, -179.56 APE8-dihe-in -90.79, 126.38 APE8-rot-in 299.46 APE67-dihe-in -69.46, -22.27 -47.42, -42.82 APE12-dist-in 8.765 APE11-dist-in 11.486 APE10-dist-in 5.626 APE9-dist-in 3.193 None None None AF2 -1.0 1.0 1.0 A 310 310 0 0 0 0 [[90, 383]] 1.0 AF-Q9Y2H1-K3 AGC_STK38L_HUMAN AGC 3.7e-100 340.3 1 260 260 230 231 232 234 236 119 138 142 210 212 211 213 305 293 288 287 286 285 284 283 282 168 Serine/threonine-protein kinase 38-like

AGC / All / All

Total number of chains: 1153
Active chains: 508
Total number of genes: 65
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 846 73.4% AF-P31749-K1A
DFGin ABAminus 172 14.9% 5M6YA
DFGin None 40 3.5% 6PJXA
DFGout None 33 2.9% 4NUSA
None None 21 1.8% 9DW7G
DFGout BBAminus 19 1.6% 6HHJA
DFGinter None 14 1.2% 3TWJB
DFGin BLAplus 4 0.3% 8XOVA
DFGin BLBplus 3 0.3% 2Z7RA
DFGin BLBminus 1 0.1% 7S26C

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Asp
χ1,χ2
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK1 GRK1_BOVIN 3T8OA P28327 30 532 561.0 ATP:562 ATPlike Active DFGin 6.784 13.652 BLAminus DFGAsp-rot-in -147.61, 176.5 66.51, 86.5 196.43, 0.8 -106.39, 20.07 278.45, 121.96 -78.51, -8.51 in-in in 9.131 Saltbr-in 2.946 HRD-in -72.08, -59.57 74.93, 15.13 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.6, 145.4 APE9-dihe-na 140.82, -165.62 APE8-dihe-in -114.33, 123.31 APE8-rot-in 302.45 APE67-dihe-inflip 90.49, -9.25 -48.36, 136.06 APE12-dist-in 10.419 APE11-dist-in 11.645 APE10-dist-in 5.795 APE9-dist-in 4.276 L166K None None XRAY 2.5 0.209 0.245 A 543 493 0 0 0 0 [[187, 452]] 1.0 3t8o Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WA P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 6.587 13.314 BLAminus DFGAsp-rot-in -157.51, 175.0 67.79, 80.23 195.58, 6.55 -106.97, 21.1 277.77, 138.55 -72.95, -18.52 in-in in 8.671 Saltbr-in 2.659 HRD-in -67.86, -51.97 60.46, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.73, 153.77 APE9-dihe-na 125.45, -175.95 APE8-dihe-in -101.44, 127.92 APE8-rot-in 301.93 APE67-dihe-inflip 97.46, -21.92 -46.81, 133.28 APE12-dist-in 10.007 APE11-dist-in 11.248 APE10-dist-in 5.534 APE9-dist-in 3.508 None TPO8 TPO8 XRAY 2.7 0.192 999.0 A 543 494 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WB P28327 5 533 561.0 ATP:562 ATPlike Active DFGin 5.963 13.111 BLAminus DFGAsp-rot-in -155.04, 178.49 64.64, 79.84 208.2, -20.75 -103.28, 19.03 277.57, 109.21 -72.3, -19.68 in-in in 8.548 Saltbr-in 2.84 HRD-in -67.79, -54.67 64.69, 11.83 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 154.48 APE9-dihe-na 126.08, -175.35 APE8-dihe-in -101.18, 126.91 APE8-rot-in 300.91 APE67-dihe-inflip 94.23, -17.08 -47.18, 130.86 APE12-dist-in 10.103 APE11-dist-in 11.254 APE10-dist-in 5.545 APE9-dist-in 3.534 None TPO8 TPO8 XRAY 2.7 0.192 999.0 B 543 519 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XA P28327 30 533 561.0 ATP:562 ATPlike Active DFGin 6.392 13.294 BLAminus DFGAsp-rot-in -153.36, -178.73 56.38, 83.66 194.88, -19.83 -101.23, 19.01 282.86, 141.85 -58.01, -33.04 in-in in 8.623 Saltbr-in 2.825 HRD-in -65.41, -52.58 62.44, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.48, 144.22 APE9-dihe-na 128.55, -174.69 APE8-dihe-in -103.7, 129.98 APE8-rot-in 314.1 APE67-dihe-inflip 101.04, -22.84 -50.28, 132.61 APE12-dist-in 10.283 APE11-dist-in 11.237 APE10-dist-in 5.726 APE9-dist-in 3.827 None None None XRAY 2.9 0.193 999.0 A 543 496 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XB P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 5.903 13.063 BLAminus DFGAsp-rot-in -149.62, 174.69 57.3, 76.73 188.25, -5.43 -95.24, 8.98 282.05, 96.12 -51.11, -35.54 in-in in 8.642 Saltbr-in 2.675 HRD-in -62.32, -48.48 63.55, 4.44 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.42, 143.72 APE9-dihe-na 129.46, -175.16 APE8-dihe-in -98.28, 125.3 APE8-rot-in 312.69 APE67-dihe-inflip 98.15, -18.1 -45.11, 129.51 APE12-dist-in 10.201 APE11-dist-in 11.247 APE10-dist-in 5.61 APE9-dist-in 3.639 None None None XRAY 2.9 0.193 999.0 B 543 475 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4ZA P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.913 13.235 BLAminus DFGAsp-rot-in -149.46, 171.26 70.91, 78.39 199.0, -15.2 -108.02, 16.47 270.55, 111.24 -69.43, -16.01 in-in in 8.736 Saltbr-in 2.716 HRD-in -71.08, -53.07 69.31, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.53, 147.45 APE9-dihe-na 134.96, -165.72 APE8-dihe-in -111.39, 128.56 APE8-rot-in 296.58 APE67-dihe-inflip 96.79, -17.75 -54.96, 131.39 APE12-dist-in 10.43 APE11-dist-in 11.113 APE10-dist-in 5.49 APE9-dist-in 3.542 None None None XRAY 1.84 0.193 999.0 A 543 493 0 0 0 0 [[187, 452]] 1.0 3c4z Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50A P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.075 13.034 BLAminus DFGAsp-rot-in -142.59, 172.43 68.85, 78.38 202.39, -19.83 -104.12, 14.36 280.99, 104.76 -67.57, -15.07 in-in in 8.602 Saltbr-in 2.925 HRD-in -76.21, -52.36 64.46, 15.62 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.66, 144.27 APE9-dihe-na 130.37, -165.26 APE8-dihe-in -104.68, 131.22 APE8-rot-in 300.48 APE67-dihe-inflip 92.29, -6.18 -56.88, 135.03 APE12-dist-in 10.685 APE11-dist-in 11.469 APE10-dist-in 5.876 APE9-dist-in 3.473 None None None XRAY 2.6 0.19 999.0 A 543 499 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50B P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.078 13.068 BLAminus DFGAsp-rot-in -140.52, 175.4 66.53, 77.05 202.76, -17.56 -104.14, 18.55 279.39, 103.87 -67.23, -21.39 in-in in 8.532 Saltbr-in 2.721 HRD-in -71.74, -52.34 63.89, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.47, 143.37 APE9-dihe-na 137.53, -168.17 APE8-dihe-in -105.39, 125.32 APE8-rot-in 297.12 APE67-dihe-inflip 95.82, -17.57 -51.32, 135.4 APE12-dist-in 10.129 APE11-dist-in 11.115 APE10-dist-in 5.538 APE9-dist-in 3.418 None None None XRAY 2.6 0.19 999.0 B 543 496 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51A P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.735 13.235 BLAminus DFGAsp-rot-in -156.28, 178.74 57.85, 73.51 196.06, -8.55 -84.14, -2.01 283.03, 106.57 -47.35, -22.99 in-in in 8.798 Saltbr-in 2.687 HRD-in -64.41, -45.82 69.5, -19.46 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.64, 142.5 APE9-dihe-na 155.52, -169.52 APE8-dihe-in -101.5, 135.25 APE8-rot-in 300.99 APE67-dihe-inflip 84.91, 4.53 -59.96, 128.0 APE12-dist-in 10.573 APE11-dist-in 11.541 APE10-dist-in 6.152 APE9-dist-in 3.937 None None None XRAY 3.55 0.281 999.0 A 543 487 0 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51B P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.785 13.187 BLAminus DFGAsp-rot-in -156.29, 175.57 58.57, 74.43 180.61, 39.77 -85.29, -1.69 285.99, 107.07 -47.38, -22.91 in-in in 8.696 Saltbr-in 2.792 HRD-in -66.67, -42.5 63.68, -15.39 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.05, 141.93 APE9-dihe-na 155.26, -171.96 APE8-dihe-in -101.33, 138.35 APE8-rot-in 299.85 APE67-dihe-inflip 84.6, 5.24 -64.39, 128.67 APE12-dist-in 10.537 APE11-dist-in 11.598 APE10-dist-in 6.156 APE9-dist-in 3.94 None None None XRAY 3.55 0.281 999.0 B 543 461 20 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9A P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.852 13.484 BLAminus DFGAsp-rot-in -151.04, 174.48 70.22, 99.25 205.82, -29.02 -129.57, 18.73 275.22, 99.19 -61.63, -18.96 in-in in 8.961 Saltbr-in 3.127 HRD-in -61.98, -58.15 73.37, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.32, 133.82 APE9-dihe-na 142.48, -169.15 APE8-dihe-in -104.33, 125.71 APE8-rot-in 302.67 APE67-dihe-inflip 104.42, -3.83 -50.74, 122.55 APE12-dist-in 10.356 APE11-dist-in 11.014 APE10-dist-in 5.5 APE9-dist-in 3.664 T8C,N480C None None XRAY 2.7 0.194 0.229 A 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9B P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.899 13.504 BLAminus DFGAsp-rot-in -154.17, 173.67 70.5, 100.81 203.24, -26.44 -132.54, 18.75 276.87, 97.69 -56.57, -24.02 in-in in 8.931 Saltbr-in 3.099 HRD-in -65.24, -58.34 73.4, -2.88 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.53, 132.45 APE9-dihe-na 145.72, -169.79 APE8-dihe-in -103.09, 126.5 APE8-rot-in 303.38 APE67-dihe-inflip 99.94, -4.73 -52.12, 123.93 APE12-dist-in 10.368 APE11-dist-in 11.038 APE10-dist-in 5.525 APE9-dist-in 3.677 T8C,N480C None None XRAY 2.7 0.194 0.229 B 543 481 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9C P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.868 13.481 BLAminus DFGAsp-rot-in -151.87, 172.48 72.03, 98.62 205.0, -29.51 -128.19, 19.72 276.34, 98.38 -59.47, -19.79 in-in in 8.951 Saltbr-in 3.107 HRD-in -62.09, -58.44 72.04, -1.68 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.26, 134.05 APE9-dihe-na 142.83, -170.11 APE8-dihe-in -104.04, 126.58 APE8-rot-in 301.36 APE67-dihe-inflip 105.14, -2.81 -49.9, 120.73 APE12-dist-in 10.384 APE11-dist-in 11.018 APE10-dist-in 5.508 APE9-dist-in 3.673 T8C,N480C None None XRAY 2.7 0.194 0.229 C 543 482 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9D P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.923 13.517 BLAminus DFGAsp-rot-in -151.29, 174.11 71.25, 99.27 203.97, -28.89 -130.54, 20.81 276.77, 98.72 -58.99, -24.3 in-in in 8.931 Saltbr-in 3.091 HRD-in -63.44, -57.63 71.87, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.95, 134.69 APE9-dihe-na 141.2, -168.54 APE8-dihe-in -103.28, 126.55 APE8-rot-in 303.76 APE67-dihe-inflip 102.49, -2.5 -51.29, 121.62 APE12-dist-in 10.397 APE11-dist-in 11.044 APE10-dist-in 5.513 APE9-dist-in 3.693 T8C,N480C None None XRAY 2.7 0.194 0.229 D 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4YA P28327 30 532 561.0 No_ligand No_ligand Inactive DFGin 7.69 11.351 BLAminus DFGAsp-rot-in -137.44, 168.27 58.91, 104.81 205.55, 48.12 -126.41, 38.75 308.65, 132.27 -61.68, -52.44 in-out in 9.833 Saltbr-out 4.389 HRD-in -106.52, -35.17 66.74, -61.42 out-in-in SNCoii in-in ActLoopNT-in 3.244 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -178.5, 156.22 APE9-dihe-na 145.3, -132.92 APE8-dihe-in -136.09, 120.97 APE8-rot-in 304.15 APE67-dihe-inflip 122.03, -39.54 -49.39, 107.36 APE12-dist-in 11.423 APE11-dist-in 12.665 APE10-dist-in 7.641 APE9-dist-in 5.75 None None None XRAY 7.509 0.182 999.0 A 543 478 2 0 0 0 [[187, 452]] 1.0 3c4y Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4L9IA P28327 30 533 561.0 8PR:601 Type1 Inactive DFGin 5.772 13.454 BLAminus DFGAsp-rot-in -149.91, 178.73 54.74, 79.81 204.11, -3.89 -98.99, 23.91 282.53, 102.36 -68.07, -19.68 in-out in 8.693 Saltbr-out 3.808 HRD-in -75.83, -53.93 68.31, 13.36 out-in-in SNCoii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.8, 142.88 APE9-dihe-na 125.17, -158.26 APE8-dihe-in -112.07, 133.06 APE8-rot-in 301.6 APE67-dihe-inflip 94.99, -2.22 -45.66, 120.79 APE12-dist-in 10.616 APE11-dist-in 11.383 APE10-dist-in 5.808 APE9-dist-in 3.723 None None None XRAY 2.32 0.188 0.231 A 504 504 0 0 0 0 [[187, 452]] 1.0 4l9i Bos taurus AGC_GRK1_BOVIN AGC 2.6e-80 275.4 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4L9IB P28327 31 533 561.0 8PR:601 Type1 Active DFGin 5.715 13.064 BLAminus DFGAsp-rot-in -147.41, -179.95 59.09, 74.76 196.86, -7.4 -90.68, 22.77 285.65, 103.28 -76.71, -12.5 in-in in 8.758 Saltbr-in 3.117 HRD-in -77.55, -56.18 71.16, 4.39 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.45, 143.07 APE9-dihe-na 140.89, -160.87 APE8-dihe-in -115.15, 127.72 APE8-rot-in 297.19 APE67-dihe-inflip 102.74, -33.6 -52.94, 132.06 APE12-dist-in 10.292 APE11-dist-in 11.221 APE10-dist-in 5.642 APE9-dist-in 3.766 None None None XRAY 2.32 0.188 0.231 B 504 493 0 0 0 0 [[187, 452]] 1.0 4l9i Bos taurus AGC_GRK1_BOVIN AGC 2.6e-80 275.4 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4WBOA P28327 28 533 561.0 ANW:601 Type1 Inactive DFGin 5.948 13.258 BLAminus DFGAsp-rot-in -146.44, 170.56 64.48, 78.76 197.01, -9.43 -93.1, 25.97 287.19, 103.23 -64.53, -31.02 in-out in 9.44 Saltbr-out 4.17 HRD-in -74.57, -52.51 66.08, 11.01 out-in-in SNCoii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.31, 145.0 APE9-dihe-na 138.11, -171.62 APE8-dihe-in -107.94, 132.02 APE8-rot-in 308.16 APE67-dihe-inflip 100.64, -17.52 -51.85, 128.49 APE12-dist-in 10.258 APE11-dist-in 11.13 APE10-dist-in 5.52 APE9-dist-in 3.53 None None None XRAY 2.81 0.243 0.267 A 541 497 0 0 0 0 [[187, 452]] 1.0 4wbo Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4WBOB P28327 30 533 561.0 ANW:601 Type1 Inactive DFGin 5.954 13.289 BLAminus DFGAsp-rot-in -146.62, 171.17 63.95, 77.64 197.19, -9.67 -91.91, 26.29 286.92, 103.21 -63.89, -32.19 in-out in 9.517 Saltbr-out 4.197 HRD-in -74.66, -52.71 66.21, 10.61 out-in-in SNCoii in-in ActLoopNT-in 2.811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.36, 145.07 APE9-dihe-na 138.91, -171.46 APE8-dihe-in -107.75, 132.29 APE8-rot-in 308.55 APE67-dihe-inflip 100.74, -17.56 -52.36, 128.88 APE12-dist-in 10.254 APE11-dist-in 11.13 APE10-dist-in 5.513 APE9-dist-in 3.525 None None None XRAY 2.81 0.243 0.267 B 541 495 0 0 0 0 [[187, 452]] 1.0 4wbo Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4WBOC P28327 31 531 561.0 ANW:601 Type1 Inactive DFGin 5.956 13.163 BLAminus DFGAsp-rot-in -146.21, 170.22 64.35, 78.08 196.77, -10.71 -92.41, 26.2 287.47, 102.96 -63.87, -32.11 in-out in 9.397 Saltbr-out 3.769 HRD-in -74.89, -52.54 66.21, 10.58 out-in-in SNCoii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.19, 145.1 APE9-dihe-na 138.92, -171.47 APE8-dihe-in -107.47, 132.18 APE8-rot-in 308.34 APE67-dihe-inflip 100.67, -17.42 -51.93, 128.63 APE12-dist-in 10.252 APE11-dist-in 11.129 APE10-dist-in 5.512 APE9-dist-in 3.526 None None None XRAY 2.81 0.243 0.267 C 541 481 0 0 0 0 [[187, 452]] 1.0 4wbo Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4WBOD P28327 30 531 561.0 ANW:601 Type1 Inactive DFGin 5.964 13.245 BLAminus DFGAsp-rot-in -146.28, 170.52 64.39, 78.16 196.3, -9.9 -92.93, 26.26 287.26, 103.4 -64.25, -31.88 in-out in 9.443 Saltbr-out 4.168 HRD-in -74.7, -52.76 66.23, 10.86 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.01, 145.2 APE9-dihe-na 138.57, -171.52 APE8-dihe-in -107.49, 131.96 APE8-rot-in 308.49 APE67-dihe-inflip 100.73, -17.59 -51.76, 128.57 APE12-dist-in 10.277 APE11-dist-in 11.157 APE10-dist-in 5.53 APE9-dist-in 3.529 None None None XRAY 2.81 0.243 0.267 D 541 491 0 0 0 0 [[187, 452]] 1.0 4wbo Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 4PNIA P28327 30 533 561.0 KQQ:601 Type1 Active DFGin 5.736 13.128 BLAminus DFGAsp-rot-in -134.98, -179.15 54.91, 73.26 214.31, -35.05 -92.23, 19.47 279.07, 113.0 -67.01, -18.73 in-in in 9.681 Saltbr-in 3.106 HRD-in -69.25, -51.31 65.76, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.87, 143.44 APE9-dihe-na 144.11, -165.57 APE8-dihe-in -117.94, 131.85 APE8-rot-in 290.67 APE67-dihe-inflip 103.74, -23.28 -58.63, 131.5 APE12-dist-in 10.34 APE11-dist-in 11.354 APE10-dist-in 5.722 APE9-dist-in 3.681 None None None XRAY 1.85 0.191 0.23 A 561 492 0 0 0 0 [[187, 452]] 1.0 4pni Bos taurus AGC_GRK1_BOVIN AGC 3.4e-80 275.0 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 7MT9G P28327 6 508 561.0 SGV:601,SGV:601,SGV:601,SGV:601,SGV:601,SGV:601 Type1,Type1,Type1,Type1,Type1,Type1 Inactive DFGin 5.674 13.06 BLAminus DFGAsp-rot-in -151.44, 153.5 75.1, 83.16 186.55, 6.89 -101.64, 23.22 308.74, 9.79 -95.55, -5.25 in-out in 8.376 Saltbr-out 3.781 HRD-out -84.42, -25.78 58.78, -116.78 out-in-out SNCoio in-out ActLoopNT-in 2.997 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iiio APE10-dihe-na -156.18, 168.76 APE9-dihe-na 65.79, -175.16 APE8-dihe-in -118.77, 133.16 APE8-rot-in 303.35 APE67-dihe-inflip 85.9, 7.81 -39.32, 131.4 APE12-dist-in 12.427 APE11-dist-in 12.028 APE10-dist-in 6.48 APE9-dist-out 6.781 None None None EM 7.0 999.0 999.0 G 543 346 0 0 0 0 [[187, 452]] 1.0 7mt9 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 7MT8G P28327 6 508 561.0 SGV:601,SGV:601,SGV:601,SGV:601,SGV:601,SGV:601 Type1,Type1,Type1,Type1,Type1,Type1 Inactive DFGin 5.278 13.851 BLAminus DFGAsp-rot-out -151.24, 148.8 73.0, 121.86 298.47, -7.78 -132.91, 52.67 297.42, 171.65 -103.81, -13.33 in-in in 8.772 Saltbr-in 3.279 HRD-in -93.25, -20.41 75.09, -77.24 in-in-out SNCiio in-out ActLoopNT-in 3.035 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.01, 152.4 APE9-dihe-na 69.43, 177.13 APE8-dihe-in -91.35, 141.08 APE8-rot-out 53.33 APE67-dihe-inflip 95.78, 14.3 -52.12, 148.5 APE12-dist-in 10.709 APE11-dist-in 10.351 APE10-dist-in 4.95 APE9-dist-in 3.409 S5E,S488E,T489E None None EM 5.8 999.0 999.0 G 543 346 0 0 0 0 [[187, 452]] 1.0 7mt8 Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 7MTAG P28327 6 508 561.0 SGV:601,SGV:601,SGV:601,SGV:601,SGV:601,SGV:601 Type1,Type1,Type1,Type1,Type1,Type1 Inactive DFGin 4.09 13.844 BLAminus DFGAsp-rot-in -167.88, 170.04 60.34, 64.21 194.94, 19.05 -82.37, 97.38 303.24, 179.85 -89.6, -128.64 in-out in 8.659 Saltbr-out 5.199 HRD-in -95.2, -46.79 83.22, -60.37 out-in-in SNCoii in-in ActLoopNT-in 3.091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.79, 133.35 APE9-dihe-na 142.18, 170.18 APE8-dihe-in -78.99, 123.97 APE8-rot-in 304.47 APE67-dihe-inflip 89.96, 4.75 -51.0, 134.99 APE12-dist-in 11.104 APE11-dist-in 11.025 APE10-dist-in 5.589 APE9-dist-in 3.794 S5E,S488E,T489E None None EM 4.1 999.0 999.0 G 543 346 0 0 0 0 [[187, 452]] 1.0 7mta Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 7MTBG P28327 6 508 561.0 SGV:601,SGV:601,SGV:601,SGV:601,SGV:601,SGV:601 Type1,Type1,Type1,Type1,Type1,Type1 Active DFGin 5.447 13.977 BLAminus DFGAsp-rot-in -158.7, 161.68 75.49, 110.48 181.15, 14.12 -135.3, 45.5 298.35, 172.26 -102.18, -14.04 in-in in 8.184 Saltbr-in 3.233 HRD-in -84.4, -44.53 73.27, 9.15 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -63.06, 150.99 APE9-dihe-na 114.44, 173.54 APE8-dihe-in -100.2, 123.65 APE8-rot-in 303.1 APE67-dihe-inflip 95.63, -25.77 -41.47, 136.01 APE12-dist-in 10.104 APE11-dist-in 10.473 APE10-dist-in 4.814 APE9-dist-in 3.216 S5E,S488E,T489E None None EM 4.0 999.0 999.0 G 543 346 0 0 0 0 [[187, 452]] 1.0 7mtb Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4YB P28327 30 532 561.0 No_ligand No_ligand Inactive DFGinter 8.04 10.553 None DFGAsp-rot-in -138.64, 168.89 59.27, 104.12 204.97, 48.94 -125.95, 37.77 308.57, 133.4 -61.52, -52.16 in-out in 9.832 Saltbr-out 4.417 HRD-in -105.99, -36.37 67.54, -61.73 out-in-in SNCoii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -178.33, 157.76 APE9-dihe-na 144.04, -133.41 APE8-dihe-in -135.26, 121.19 APE8-rot-in 303.52 APE67-dihe-inflip 122.3, -40.41 -49.79, 107.51 APE12-dist-in 11.426 APE11-dist-in 12.656 APE10-dist-in 7.632 APE9-dist-in 5.789 None None None XRAY 7.509 0.182 999.0 B 543 466 8 0 0 0 [[187, 452]] 1.0 3c4y Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK2 ARBK1_BOVIN 1YM7B P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.199 12.448 ABAminus DFGAsp-rot-in -130.8, -59.92 -98.26, 108.63 203.26, 72.35 -91.58, -9.04 306.19, 95.69 -36.4, -48.74 in-out in 8.803 Saltbr-out 4.642 HRD-in -77.09, -44.3 73.62, -27.39 out-in-in SNCoii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.17, 125.32 APE9-dihe-na 152.82, 174.56 APE8-dihe-in -87.32, 142.62 APE8-rot-in 313.75 APE67-dihe-in -64.86, -36.54 -62.56, -29.46 APE12-dist-in 9.818 APE11-dist-in 11.56 APE10-dist-in 5.573 APE9-dist-in 4.036 S670A None None XRAY 4.5 0.226 0.279 B 689 608 0 0 0 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.508 12.214 ABAminus DFGAsp-rot-in -113.28, -56.44 -93.74, 100.06 188.28, 0.99 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.933 Saltbr-out 4.217 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.726 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.902 APE11-dist-in 12.01 APE10-dist-in 6.099 APE9-dist-in 3.63 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus DFGAsp-rot-in -113.22, -56.58 -93.6, 101.44 190.92, 5.46 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.989 Saltbr-out 4.654 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.713 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.316 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.157 ABAminus DFGAsp-rot-in -113.24, -56.55 -93.57, 101.39 190.99, 5.37 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.989 Saltbr-out 4.653 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.653 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.714 APE11-dist-in 11.989 APE10-dist-in 5.989 APE9-dist-in 4.317 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688 658 0 0 0 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 5HE0A P21146 30 668 689.0 453:701 Type1 Inactive DFGin 5.259 13.117 BLAminus DFGAsp-rot-out -137.72, 161.16 67.72, 86.34 292.7, 27.16 -84.98, 14.88 287.85, 80.12 -42.13, -60.12 in-in in 8.467 Saltbr-in 2.868 HRD-in -68.65, -49.34 77.87, -29.18 in-in-in SNCiii in-in ActLoopNT-in 2.859 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.25, 120.14 APE9-dihe-na 171.2, -142.82 APE8-dihe-in -122.87, 132.42 APE8-rot-in 285.63 APE67-dihe-inflip 113.92, -33.46 -57.37, 128.9 APE12-dist-in 10.174 APE11-dist-in 11.771 APE10-dist-in 5.88 APE9-dist-in 3.549 S670A None None XRAY 2.56 0.205 0.264 A 641 621 0 0 0 0 [[191, 453]] 1.0 5he0 Bos taurus AGC_GRK2_BOVIN AGC 5.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 5HE2A P21146 30 668 689.0 F0S:701 Type1 Inactive DFGin 5.266 13.432 BLAminus DFGAsp-rot-out -127.84, 162.02 76.97, 74.62 277.11, 50.4 -82.13, 19.63 285.89, 54.35 -44.91, -55.91 in-in in 8.699 Saltbr-in 2.671 HRD-in -87.07, -48.72 79.5, -27.96 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.3, 135.41 APE9-dihe-na 128.88, -173.45 APE8-dihe-in -85.86, 172.32 APE8-rot-in 301.72 APE67-dihe-in -88.54, 16.07 -85.52, -45.68 APE12-dist-in 10.698 APE11-dist-in 11.931 APE10-dist-in 5.993 APE9-dist-in 3.782 S670A None None XRAY 2.79 0.202 0.277 A 641 628 0 0 0 0 [[191, 453]] 1.0 5he2 Bos taurus AGC_GRK2_BOVIN AGC 5.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 5HE3A P21146 30 670 689.0 FF1:702 Type1 Active DFGin 5.471 13.112 BLAminus DFGAsp-rot-in -130.61, 154.77 82.75, 74.09 196.32, -6.06 -80.19, 15.36 283.76, 73.33 -31.6, -75.24 in-in in 8.613 Saltbr-in 2.752 HRD-in -66.32, -31.89 63.86, -19.84 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 142.9 APE9-dihe-na 127.74, 174.69 APE8-dihe-in -90.13, 145.29 APE8-rot-in 301.32 APE67-dihe-inflip 112.74, -14.85 -68.46, 126.13 APE12-dist-in 10.205 APE11-dist-in 11.708 APE10-dist-in 5.915 APE9-dist-in 3.371 None None None XRAY 2.74 0.198 0.257 A 641 623 0 0 0 0 [[191, 453]] 1.0 5he3 Bos taurus AGC_GRK2_BOVIN AGC 5.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 5UKMA P21146 31 669 689.0 T0E:701 Type1 Inactive DFGin 5.559 13.132 BLAminus DFGAsp-rot-out -130.36, 150.32 61.48, 90.2 287.7, 13.5 -96.51, 21.64 296.35, 62.89 -55.13, -59.92 in-in in 9.017 Saltbr-in 2.786 HRD-in -71.89, -48.96 73.51, -73.8 in-in-in SNCiii in-in ActLoopNT-in 3.167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.94, 135.34 APE9-dihe-na 121.47, 173.74 APE8-dihe-in -77.03, 143.73 APE8-rot-in 316.68 APE67-dihe-in -68.91, -23.51 -68.56, -33.79 APE12-dist-in 10.303 APE11-dist-in 11.61 APE10-dist-in 5.834 APE9-dist-in 5.313 S670A None None XRAY 3.03 0.2 0.252 A 695 621 0 0 0 0 [[191, 453]] 1.0 5ukm Bos taurus AGC_GRK2_BOVIN AGC 6.6e-77 268.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1OMWA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.448 13.069 None DFGAsp-rot-in -112.27, -91.9 -67.18, 126.78 199.38, 56.08 -99.0, 7.24 286.96, 109.41 -44.09, -46.49 in-in in 8.937 Saltbr-in 3.411 HRD-in -73.22, -52.41 80.02, -28.79 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.71, 128.56 APE9-dihe-na 124.77, -168.54 APE8-dihe-in -89.28, 150.91 APE8-rot-in 295.71 APE67-dihe-in -77.59, -9.92 -72.81, -27.02 APE12-dist-in 10.588 APE11-dist-in 11.877 APE10-dist-in 6.194 APE9-dist-in 3.503 S670A None None XRAY 2.5 0.216 0.252 A 689 614 0 0 0 0 [[191, 453]] 1.0 1omw Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7A P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.224 12.357 None DFGAsp-rot-in -125.66, -66.29 -94.21, 107.11 205.15, 68.28 -86.73, -10.11 307.87, 97.53 -38.26, -47.46 in-out in 8.853 Saltbr-out 4.637 HRD-in -74.94, -45.18 74.24, -26.22 out-in-in SNCoii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 123.21 APE9-dihe-na 155.55, 174.57 APE8-dihe-in -86.11, 141.22 APE8-rot-in 314.43 APE67-dihe-in -66.31, -34.76 -64.21, -27.3 APE12-dist-in 9.831 APE11-dist-in 11.543 APE10-dist-in 5.593 APE9-dist-in 3.993 S670A None None XRAY 4.5 0.226 0.279 A 689 608 0 0 0 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7C P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.267 None DFGAsp-rot-in -130.34, -66.38 -92.79, 106.85 203.82, 70.02 -85.97, -13.2 309.12, 95.06 -35.96, -48.47 in-out in 8.814 Saltbr-out 4.736 HRD-in -75.86, -48.89 75.97, -29.41 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.29, 128.8 APE9-dihe-na 145.96, 173.8 APE8-dihe-in -87.44, 141.12 APE8-rot-in 314.72 APE67-dihe-in -67.09, -36.43 -60.22, -25.52 APE12-dist-in 9.775 APE11-dist-in 11.569 APE10-dist-in 5.607 APE9-dist-in 4.058 S670A None None XRAY 4.5 0.226 0.279 C 689 607 0 0 0 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 1YM7D P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.234 12.344 None DFGAsp-rot-in -128.88, -67.33 -92.65, 105.41 204.82, 72.92 -87.88, -10.71 307.83, 96.53 -37.49, -49.46 in-out in 8.801 Saltbr-out 4.746 HRD-in -72.13, -45.13 72.62, -27.86 out-in-in SNCoii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.27, 125.22 APE9-dihe-na 149.39, 173.11 APE8-dihe-in -84.5, 141.69 APE8-rot-in 315.18 APE67-dihe-in -66.11, -35.98 -62.26, -27.83 APE12-dist-in 9.736 APE11-dist-in 11.497 APE10-dist-in 5.533 APE9-dist-in 4.029 S670A None None XRAY 4.5 0.226 0.279 D 689 599 0 0 0 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 2BCJA P21146 28 667 689.0 No_ligand No_ligand Inactive DFGin 5.153 12.375 None DFGAsp-rot-in -114.23, -125.71 -23.26, 91.28 202.9, -24.35 -81.33, 0.62 275.63, 158.44 -51.51, -42.54 in-in in 8.62 Saltbr-in 2.633 HRD-in -86.19, -45.87 70.94, -23.92 in-in-in SNCiii in-in ActLoopNT-in 2.719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 137.19 APE9-dihe-na 118.03, -177.98 APE8-dihe-in -75.0, 121.63 APE8-rot-in 302.92 APE67-dihe-in -97.57, -19.7 -76.89, 19.37 APE12-dist-in 11.04 APE11-dist-in 11.941 APE10-dist-in 6.006 APE9-dist-in 3.715 S670A None None XRAY 3.061 0.236 0.292 A 689 624 0 0 0 0 [[191, 453]] 1.0 2bcj Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZSA P21146 29 671 689.0 No_ligand No_ligand Inactive DFGin 5.731 11.149 None DFGAsp-rot-in -107.21, -110.21 -68.72, 97.64 191.05, -64.49 -52.38, -56.06 299.08, 3.09 42.56, -75.63 in-out in 9.005 Saltbr-out 3.921 HRD-in -77.33, -41.02 60.69, 32.77 out-in-out SNCoio in-out ActLoopNT-in 3.529 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -98.18, 142.14 APE9-dihe-na 139.16, 169.96 APE8-dihe-in -74.03, 124.78 APE8-rot-in 315.02 APE67-dihe-out 166.07, -43.85 -59.08, 78.84 APE12-dist-in 10.239 APE11-dist-in 12.097 APE10-dist-in 6.31 APE9-dist-in 3.514 S670A None None XRAY 4.52 0.188 0.268 A 689 609 20 0 0 0 [[191, 453]] 1.0 3uzs Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3UZTA P21146 30 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.499 None DFGAsp-rot-in -94.28, -95.77 -83.37, 90.84 200.84, 54.65 -54.75, -37.85 271.69, 47.64 -2.65, -69.38 in-out in 8.826 Saltbr-out 5.081 HRD-in -72.79, -37.98 67.02, -27.54 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.51, 148.65 APE9-dihe-na 138.76, 168.6 APE8-dihe-in -71.39, 126.55 APE8-rot-in 294.92 APE67-dihe-in -71.95, -17.71 -54.34, -25.29 APE12-dist-in 9.533 APE11-dist-in 12.01 APE10-dist-in 5.989 APE9-dist-in 3.869 S670A None None XRAY 3.51 0.22 0.317 A 689 586 12 0 0 0 [[191, 453]] 1.0 3uzt Bos taurus AGC_GRK2_BOVIN AGC 6.5e-77 268.8 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PSCA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.484 12.825 None DFGAsp-rot-in -112.1, -116.4 -50.02, 128.26 176.32, 24.68 -100.71, 13.15 287.53, 88.47 -45.02, -46.74 in-in in 8.888 Saltbr-in 3.114 HRD-in -73.4, -47.49 67.75, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.59, 142.02 APE9-dihe-na 121.44, 174.37 APE8-dihe-in -79.3, 138.73 APE8-rot-in 323.05 APE67-dihe-in -80.94, 3.9 -61.06, -31.71 APE12-dist-in 10.117 APE11-dist-in 11.763 APE10-dist-in 5.929 APE9-dist-in 3.192 S670A None None XRAY 2.67 0.225 0.257 A 695 614 0 0 0 0 [[191, 453]] 1.0 3psc Bos taurus AGC_GRK2_BOVIN AGC 6.6e-77 268.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVUA P21146 30 668 689.0 QRW:800 Type1 Inactive DFGin 5.429 12.55 None DFGAsp-rot-in -114.2, -126.97 -29.78, 116.79 182.15, -2.85 -95.83, 7.38 283.37, 161.7 -55.56, -22.85 in-in in 8.749 Saltbr-in 2.986 HRD-in -71.34, -46.23 80.59, -11.92 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.26, 142.91 APE9-dihe-na 117.3, -165.9 APE8-dihe-in -102.62, 148.45 APE8-rot-in 314.0 APE67-dihe-in -77.54, 11.33 -67.23, -35.08 APE12-dist-in 10.284 APE11-dist-in 11.89 APE10-dist-in 6.186 APE9-dist-in 3.42 S670A None None XRAY 2.48 0.229 0.274 A 695 609 0 0 0 0 [[191, 453]] 1.0 3pvu Bos taurus AGC_GRK2_BOVIN AGC 6.6e-77 268.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK2 ARBK1_BOVIN 3PVWA P21146 29 668 689.0 QRX:800 Type1 Inactive DFGin 5.249 12.397 None DFGAsp-rot-in -104.93, -94.33 -60.0, 121.61 195.48, -4.45 -95.37, 6.96 285.31, 4.38 -65.85, -19.47 in-in in 8.749 Saltbr-in 3.07 HRD-in -69.01, -52.71 78.6, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.25, 142.6 APE9-dihe-na 127.77, 176.65 APE8-dihe-in -84.9, 148.79 APE8-rot-in 327.3 APE67-dihe-in -77.16, 13.46 -65.86, -42.83 APE12-dist-in 10.738 APE11-dist-in 12.187 APE10-dist-in 6.412 APE9-dist-in 3.337 S670A None None XRAY 2.49 0.239 0.285 A 695 613 0 0 0 0 [[191, 453]] 1.0 3pvw Bos taurus AGC_GRK2_BOVIN AGC 6.6e-77 268.7 1 260 260 334 335 336 338 340 220 239 243 314 316 315 317 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
AGC GRK5 GRK5_BOVIN 4WNKA P43249 24 541 590.0 453:60701 Type1.5_Front Inactive DFGin 6.267 12.797 ABAminus DFGAsp-rot-in -122.04, -4.62 -137.77, 133.15 190.13, -65.06 -132.09, 26.08 277.95, 69.95 -56.52, -33.29 in-in in 8.484 Saltbr-in 2.781 HRD-in -75.83, -57.19 76.27, -3.2 in-in-in SNCiii in-in ActLoopNT-in 3.03 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.86, 160.08 APE9-dihe-na 138.36, -161.11 APE8-dihe-in -117.24, 138.85 APE8-rot-in 306.21 APE67-dihe-inflip 84.72, -13.63 -52.7, 138.28 APE12-dist-in 10.076 APE11-dist-in 11.951 APE10-dist-in 6.101 APE9-dist-in 3.92 None None None XRAY 2.42 0.196 0.243 A 598 499 0 0 0 0 [[186, 448]] 1.0 4wnk Bos taurus AGC_GRK5_BOVIN AGC 2.3e-84 288.8 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PRKACA KAPCA_BOVIN 2GNIA P00517 11 351 351.0 M77:60601 Type1 Inactive DFGin 6.122 13.339 ABAminus DFGAsp-rot-in -125.47, 13.51 -148.05, 120.42 188.06, -27.63 -113.28, 22.31 295.85, 71.04 -57.43, -24.9 in-in in 9.251 Saltbr-in 2.862 HRD-in -97.25, -49.49 72.22, 6.42 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.86, 164.06 APE9-dihe-na 122.41, -161.87 APE8-dihe-in -119.99, 136.29 APE8-rot-in 295.68 APE67-dihe-in -63.27, -25.72 -47.9, -45.46 APE12-dist-in 8.141 APE11-dist-in 11.265 APE10-dist-in 5.779 APE9-dist-in 3.376 L50I,V124M,E128D,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.27 0.192 0.268 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gni Bos taurus AGC_PRKACA_BOVIN AGC 2.2e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1STCE P00517 16 351 351.0 STU:60351 Type1 Inactive DFGin 6.125 14.676 ABAminus DFGAsp-rot-in -152.28, -21.25 -98.94, 113.28 168.45, 69.99 -112.23, 27.12 284.07, 102.64 -65.61, -29.61 in-in in 9.174 Saltbr-in 2.608 HRD-out -84.15, -57.61 42.07, 55.99 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 156.46 APE9-dihe-na 129.45, -158.0 APE8-dihe-in -121.73, 124.56 APE8-rot-in 292.46 APE67-dihe-in -75.12, -21.46 -28.7, -46.78 APE12-dist-in 8.387 APE11-dist-in 11.162 APE10-dist-in 5.826 APE9-dist-in 4.443 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.3 0.208 0.33 E 350 336 0 0 0 0 [[44, 298]] 1.0 1stc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3ZO2A P00517 8 351 351.0 15I:61351 Type1 Inactive DFGin 6.144 13.757 ABAminus DFGAsp-rot-out -111.64, -15.7 -114.7, 103.29 293.85, 75.45 -107.0, 15.63 291.73, 77.0 -53.95, -31.44 in-in in 8.983 Saltbr-in 2.709 HRD-in -83.31, -56.68 67.99, 8.34 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 157.34 APE9-dihe-na 124.98, -162.06 APE8-dihe-in -114.19, 137.15 APE8-rot-in 302.62 APE67-dihe-in -58.09, -28.32 -43.68, -52.1 APE12-dist-in 8.012 APE11-dist-in 11.469 APE10-dist-in 5.839 APE9-dist-in 3.61 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.98 0.158 0.191 A 351 344 0 0 0 0 [[44, 298]] 1.0 3zo2 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3ZO3A P00517 12 351 351.0 QNI:61351 Type1 Inactive DFGin 5.814 14.558 ABAminus DFGAsp-rot-out -113.45, -3.91 -119.58, 103.74 287.53, 73.4 -104.44, 16.56 281.0, 73.71 -59.51, -27.51 in-in in 9.119 Saltbr-in 2.788 HRD-in -88.87, -55.75 64.02, 12.24 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 157.3 APE9-dihe-na 125.82, -155.48 APE8-dihe-in -117.69, 139.23 APE8-rot-in 297.95 APE67-dihe-in -57.23, -32.24 -46.12, -52.37 APE12-dist-in 7.972 APE11-dist-in 11.331 APE10-dist-in 5.762 APE9-dist-in 3.652 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.1 0.176 0.21 A 351 340 0 0 0 0 [[44, 298]] 1.0 3zo3 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 5VI9A P00517 15 351 351.0 9D4:60401 Type1 Inactive DFGin 6.413 14.639 ABAminus DFGAsp-rot-out -108.08, -28.68 -104.39, 134.13 291.67, 19.93 -134.73, 37.16 293.35, 85.38 -60.78, -29.79 in-out in 9.386 Saltbr-out 3.754 HRD-in -77.99, -57.09 68.94, 10.33 out-in-in SNCoii in-in ActLoopNT-in 2.847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.52, 160.7 APE9-dihe-na 121.66, -160.6 APE8-dihe-in -114.63, 135.81 APE8-rot-in 302.32 APE67-dihe-in -61.89, -29.97 -46.88, -46.56 APE12-dist-in 8.083 APE11-dist-in 11.498 APE10-dist-in 5.826 APE9-dist-in 3.636 None TPO198 TPO198 XRAY 1.95 0.209 0.256 A 351 307 4 0 0 0 [[44, 298]] 1.0 5vi9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 5VIBA P00517 19 351 351.0 9D1:60401 Type1 Inactive DFGin 6.621 14.832 ABAminus DFGAsp-rot-in -107.11, -34.58 -98.31, 117.88 210.96, -54.59 -117.47, 22.93 281.07, 85.16 -57.39, -18.74 in-in in 9.187 Saltbr-in 3.561 HRD-in -77.43, -53.28 63.56, 13.71 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.02, 160.82 APE9-dihe-na 122.63, -164.02 APE8-dihe-in -113.1, 131.73 APE8-rot-in 301.25 APE67-dihe-in -62.36, -27.21 -42.7, -49.96 APE12-dist-in 7.948 APE11-dist-in 11.416 APE10-dist-in 5.756 APE9-dist-in 3.504 None TPO198 TPO198 XRAY 2.37 0.215 0.276 A 351 309 0 0 0 0 [[44, 298]] 1.0 5vib Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SZMB P00517 15 351 351.0 BI4:60351 Type1 Inactive DFGin 6.916 16.017 ABAminus DFGAsp-rot-in -124.67, -37.03 -119.38, 110.7 195.32, -43.68 -112.86, 23.01 290.52, 94.06 -59.96, -45.74 out-out out 10.618 Saltbr-out 4.666 HRD-in -70.48, -44.14 31.9, 37.49 out-in-in SNCoii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.49, 166.21 APE9-dihe-na 109.44, 164.47 APE8-dihe-in -71.29, 133.53 APE8-rot-in 294.81 APE67-dihe-in -63.33, -24.2 -45.0, -46.86 APE12-dist-in 8.346 APE11-dist-in 11.522 APE10-dist-in 5.985 APE9-dist-in 4.445 V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.5 0.234 0.289 B 350 323 0 0 0 0 [[44, 298]] 1.0 1szm Bos taurus AGC_PRKACA_BOVIN AGC 1.7e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4AXAA P00517 15 351 351.0 RKD:61351 Type1 Inactive DFGin 6.203 13.896 ABAminus DFGAsp-rot-out -121.83, -29.08 -102.06, 117.48 305.95, -28.68 -118.59, 24.36 279.49, 73.66 -60.99, -27.08 in-in in 8.761 Saltbr-in 3.007 HRD-in -91.45, -56.33 70.15, 3.62 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.21, 158.94 APE9-dihe-na 126.47, -155.87 APE8-dihe-in -119.74, 130.42 APE8-rot-in 299.77 APE67-dihe-in -59.64, -26.03 -40.97, -51.19 APE12-dist-in 7.997 APE11-dist-in 11.418 APE10-dist-in 5.855 APE9-dist-in 3.705 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.216 0.256 A 351 337 0 0 0 0 [[44, 298]] 1.0 4axa Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C34A P00517 11 351 351.0 STU:61351 Type1 Inactive DFGin 6.517 14.849 ABAminus DFGAsp-rot-in -119.31, -40.44 -98.64, 112.68 190.41, -18.25 -107.28, 23.29 283.36, 88.13 -59.12, -19.89 in-in in 8.864 Saltbr-in 2.985 HRD-in -78.06, -54.1 69.84, 7.38 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.66, 162.66 APE9-dihe-na 118.12, -166.39 APE8-dihe-in -111.07, 134.19 APE8-rot-in 303.77 APE67-dihe-in -56.72, -26.94 -46.04, -52.13 APE12-dist-in 8.398 APE11-dist-in 11.458 APE10-dist-in 5.765 APE9-dist-in 3.408 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.78 0.18 0.214 A 351 340 0 0 0 0 [[44, 298]] 1.0 4c34 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C37A P00517 14 351 351.0 Z21:61351 Type1 Inactive DFGin 6.262 14.284 ABAminus DFGAsp-rot-in -113.24, -47.75 -78.1, 110.9 188.85, 4.25 -112.08, 25.76 272.69, 64.65 -57.89, -26.17 in-in in 8.728 Saltbr-in 2.741 HRD-in -81.42, -53.5 70.95, 1.92 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.71, 160.19 APE9-dihe-na 127.27, -162.5 APE8-dihe-in -118.08, 133.43 APE8-rot-in 300.5 APE67-dihe-in -57.54, -26.87 -42.89, -53.17 APE12-dist-in 8.154 APE11-dist-in 11.509 APE10-dist-in 5.883 APE9-dist-in 3.537 F55Y,M121L,V124L,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.157 0.179 A 351 338 0 0 0 0 [[44, 298]] 1.0 4c37 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GNHA P00517 11 351 351.0 H52:60501,H52:60502 Type1,Allosteric Inactive DFGin 5.726 14.706 ABAminus DFGAsp-rot-in -128.79, 15.58 -151.1, 122.77 201.86, -84.51 -119.76, 23.12 270.41, 63.78 -48.67, -39.31 in-in in 9.333 Saltbr-in 2.824 HRD-in -85.53, -55.44 74.29, 10.02 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.69, 165.93 APE9-dihe-na 124.87, -164.72 APE8-dihe-in -119.96, 131.77 APE8-rot-in 295.2 APE67-dihe-in -55.53, -26.21 -49.22, -48.81 APE12-dist-in 8.171 APE11-dist-in 11.389 APE10-dist-in 5.879 APE9-dist-in 3.465 L50I,V124M,E128D,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.05 0.198 0.256 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gnh Bos taurus AGC_PRKACA_BOVIN AGC 2.2e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW5G P00517 13 351 351.0 ANP:403 ATPlike Inactive DFGin 7.334 15.877 BLAminus DFGAsp-rot-none -126.22, -169.89 60.75, 61.77 999.0, 999.0 -87.02, 21.16 273.51, 93.96 -63.0, -33.74 out-none out 10.252 Saltbr-none 999.0 HRD-in -80.85, -56.62 73.43, -6.68 none-in-in SNCnii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.11, -173.97 APE9-dihe-na 106.0, -157.25 APE8-dihe-in -108.29, 136.12 APE8-rot-in 326.0 APE67-dihe-in -63.46, -43.06 -59.57, -33.75 APE12-dist-in 9.113 APE11-dist-in 11.955 APE10-dist-in 6.81 APE9-dist-in 4.563 None TPO198 TPO198 EM 3.8 999.0 999.0 G 351 330 0 0 0 0 [[44, 298]] 1.0 9dw5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.07 14.235 BLAminus DFGAsp-rot-in -131.43, -174.72 59.27, 66.66 212.77, -31.96 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.911 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7 APE11-dist-in 11.593 APE10-dist-in 6.411 APE9-dist-in 4.803 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351 309 0 0 0 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW9G P00517 13 351 351.0 ATP:401 ATPlike Active DFGin 6.569 15.126 BLAminus DFGAsp-rot-in -133.9, -169.96 59.46, 64.31 193.14, -0.4 -83.85, 33.99 275.29, 73.58 -66.33, -24.36 in-in in 9.499 Saltbr-in 3.217 HRD-in -92.3, -53.34 68.25, 14.14 in-in-in SNCiii in-in ActLoopNT-in 3.08 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.91, 151.76 APE9-dihe-na 126.66, -174.62 APE8-dihe-in -92.84, 130.69 APE8-rot-in 299.41 APE67-dihe-in -68.55, -23.13 -58.33, -34.44 APE12-dist-in 8.703 APE11-dist-in 11.563 APE10-dist-in 6.17 APE9-dist-in 4.568 None TPO198 TPO198 EM 2.8 999.0 999.0 G 351 328 0 0 0 0 [[44, 298]] 1.0 9dw9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q24A P00517 15 351 351.0 ATP:60400 ATPlike Active DFGin 5.983 14.319 BLAminus DFGAsp-rot-in -113.95, 178.0 66.86, 85.15 199.28, 4.16 -103.99, 32.82 274.7, 64.8 -65.44, -25.66 in-in in 8.779 Saltbr-in 2.742 HRD-in -93.22, -55.61 73.46, 14.95 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 162.77 APE9-dihe-na 133.15, -143.39 APE8-dihe-in -135.22, 127.61 APE8-rot-in 301.89 APE67-dihe-in -67.43, -30.61 -42.63, -46.05 APE12-dist-in 8.036 APE11-dist-in 11.447 APE10-dist-in 6.024 APE9-dist-in 3.486 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.202 0.25 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q24 Bos taurus AGC_PRKACA_BOVIN AGC 5e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VO7A P00517 15 351 351.0 M05:61351,M05:61352 Allosteric,Type1 Active DFGin 6.059 13.354 BLAminus DFGAsp-rot-in -112.73, 170.06 64.79, 125.13 216.14, -88.01 -129.63, 24.75 288.96, 78.29 -59.84, -27.0 in-in in 8.921 Saltbr-in 2.59 HRD-in -91.38, -48.53 69.14, 8.91 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.06, 161.81 APE9-dihe-na 128.93, -157.64 APE8-dihe-in -120.9, 132.32 APE8-rot-in 302.18 APE67-dihe-in -59.27, -25.29 -43.22, -50.55 APE12-dist-in 8.102 APE11-dist-in 11.322 APE10-dist-in 5.752 APE9-dist-in 3.625 None TPO198,SEP339 TPO198,SEP339 XRAY 1.98 0.191 0.241 A 351 337 0 0 0 0 [[44, 298]] 1.0 2vo7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GNGA P00517 11 351 351.0 No_ligand No_ligand Active DFGin 6.14 14.224 BLAminus DFGAsp-rot-in -119.55, 178.04 62.47, 98.55 201.56, -19.74 -111.03, 25.12 275.63, 67.2 -58.48, -24.65 in-in in 9.005 Saltbr-in 2.696 HRD-in -96.2, -52.02 73.83, 11.43 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.01, 159.86 APE9-dihe-na 129.89, -160.93 APE8-dihe-in -123.36, 138.18 APE8-rot-in 302.01 APE67-dihe-in -59.18, -22.88 -47.61, -51.91 APE12-dist-in 8.012 APE11-dist-in 11.29 APE10-dist-in 5.802 APE9-dist-in 3.56 L50I,V124M,E128D,Q182K,T184A SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.87 0.198 0.258 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gng Bos taurus AGC_PRKACA_BOVIN AGC 2.2e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GFCA P00517 15 351 351.0 No_ligand No_ligand Active DFGin 6.188 14.071 BLAminus DFGAsp-rot-in -117.74, 159.24 72.69, 98.85 201.16, -45.95 -105.34, 28.02 271.26, 59.63 -61.26, -23.71 in-in in 8.674 Saltbr-in 2.576 HRD-in -90.3, -52.85 73.44, 9.78 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.8, 159.7 APE9-dihe-na 133.98, -157.58 APE8-dihe-in -121.29, 135.51 APE8-rot-in 301.46 APE67-dihe-in -58.17, -22.85 -42.97, -54.07 APE12-dist-in 8.034 APE11-dist-in 11.255 APE10-dist-in 5.726 APE9-dist-in 3.527 None TPO198,SEP339 TPO198,SEP339 XRAY 1.87 0.239 0.239 A 350 337 0 0 0 0 [[44, 298]] 1.0 2gfc Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3AG9A P00517 15 351 351.0 No_ligand No_ligand Inactive DFGin 7.051 16.177 BLAminus DFGAsp-rot-in -121.67, 168.31 69.6, 87.4 194.9, -18.34 -105.16, 26.26 286.68, 81.88 -58.4, -43.3 out-out out 10.486 Saltbr-out 4.763 HRD-in -75.01, -50.0 50.19, 29.04 out-in-in SNCoii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.66, 167.28 APE9-dihe-na 97.3, 169.91 APE8-dihe-in -87.06, 128.77 APE8-rot-in 296.19 APE67-dihe-in -53.54, -29.25 -42.73, -48.49 APE12-dist-in 8.336 APE11-dist-in 11.239 APE10-dist-in 5.746 APE9-dist-in 4.308 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.23 0.246 A 351 325 0 0 0 0 [[44, 298]] 1.0 3ag9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9FQRXT P00517 26 351 351.0 No_ligand No_ligand Inactive DFGin 7.504 15.472 BLAminus DFGAsp-rot-in -120.43, -175.35 59.39, 66.35 207.79, -3.19 -90.0, 32.7 274.65, 67.61 -64.07, -27.17 in-out in 8.66 Saltbr-out 4.457 HRD-in -81.78, -57.62 51.32, 20.96 out-in-in SNCoii in-in ActLoopNT-in 3.215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.53, 169.85 APE9-dihe-na 132.17, 174.57 APE8-dihe-in -89.75, 132.06 APE8-rot-in 314.38 APE67-dihe-in -73.91, -30.73 -62.64, -19.12 APE12-dist-in 8.498 APE11-dist-in 10.76 APE10-dist-in 6.022 APE9-dist-in 4.841 None None None EM 5.0 999.0 999.0 Xt 351 294 0 0 0 0 [[44, 298]] 1.0 9fqr Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q61A P00517 15 351 351.0 No_ligand No_ligand Active DFGin 6.317 14.058 BLAminus DFGAsp-rot-in -113.32, 171.66 65.32, 95.24 202.46, -31.28 -105.6, 28.35 273.54, 62.22 -60.93, -24.2 in-in in 8.77 Saltbr-in 2.792 HRD-in -88.4, -55.05 70.66, 3.99 in-in-in SNCiii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.36, 157.96 APE9-dihe-na 134.42, -161.14 APE8-dihe-in -115.93, 129.95 APE8-rot-in 300.39 APE67-dihe-in -58.76, -26.29 -47.87, -46.79 APE12-dist-in 8.177 APE11-dist-in 11.573 APE10-dist-in 6.017 APE9-dist-in 3.796 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.184 0.232 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q61 Bos taurus AGC_PRKACA_BOVIN AGC 1.7e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SMHA P00517 2 351 351.0 No_ligand No_ligand Inactive DFGin 6.799 14.58 BLAminus DFGAsp-rot-out -115.56, -165.58 57.6, 64.56 282.73, -68.39 -89.23, 16.63 272.25, 75.82 -57.78, -31.17 in-in in 8.848 Saltbr-in 2.442 HRD-in -96.56, -52.48 70.28, 5.31 in-in-in SNCiii in-in ActLoopNT-in 2.798 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.7, 159.43 APE9-dihe-na 133.86, -177.98 APE8-dihe-in -99.8, 130.8 APE8-rot-in 299.09 APE67-dihe-in -59.18, -25.63 -42.57, -53.75 APE12-dist-in 8.204 APE11-dist-in 11.557 APE10-dist-in 6.053 APE9-dist-in 3.759 Q85E,V124A,L174M,F188L TPO198,SEP339 TPO198,SEP339 XRAY 2.044 0.191 0.238 A 350 350 0 0 0 0 [[44, 298]] 1.0 1smh Bos taurus AGC_PRKACA_BOVIN AGC 3.1e-94 321.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q62A P00517 14 351 351.0 No_ligand No_ligand Active DFGin 6.182 14.277 BLAminus DFGAsp-rot-in -104.64, 174.54 66.86, 89.86 206.1, -19.66 -104.82, 25.62 276.34, 54.84 -53.41, -25.33 in-in in 8.931 Saltbr-in 2.614 HRD-in -96.79, -53.25 66.13, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.96, 166.05 APE9-dihe-na 130.72, -161.89 APE8-dihe-in -113.23, 133.18 APE8-rot-in 300.81 APE67-dihe-in -67.6, -24.51 -42.5, -46.58 APE12-dist-in 8.141 APE11-dist-in 11.427 APE10-dist-in 6.016 APE9-dist-in 3.617 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.192 0.252 A 350 338 0 0 0 0 [[44, 298]] 1.0 1q62 Bos taurus AGC_PRKACA_BOVIN AGC 5e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C33A P00517 14 351 351.0 No_ligand No_ligand Active DFGin 6.37 14.463 BLAminus DFGAsp-rot-in -122.61, 167.1 69.2, 93.31 201.15, -33.32 -104.18, 28.64 273.24, 55.76 -56.02, -28.41 in-in in 8.822 Saltbr-in 2.713 HRD-in -80.43, -53.85 71.22, 13.56 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.13, 162.95 APE9-dihe-na 124.44, -159.48 APE8-dihe-in -120.39, 137.89 APE8-rot-in 301.42 APE67-dihe-in -62.3, -24.0 -46.94, -49.76 APE12-dist-in 8.002 APE11-dist-in 11.397 APE10-dist-in 5.778 APE9-dist-in 3.438 F55Y,M121L,V124L,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.158 0.187 A 351 338 0 0 0 0 [[44, 298]] 1.0 4c33 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GNFA P00517 11 351 351.0 Y27:60501 Type1 Active DFGin 6.041 14.174 BLAminus DFGAsp-rot-in -116.96, 178.88 58.65, 105.43 201.21, -22.04 -113.78, 28.7 272.88, 66.05 -63.78, -25.92 in-in in 9.202 Saltbr-in 2.593 HRD-in -94.14, -47.78 64.37, 13.52 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.34, 163.17 APE9-dihe-na 124.68, -165.19 APE8-dihe-in -121.59, 134.6 APE8-rot-in 288.13 APE67-dihe-in -58.1, -28.51 -44.73, -50.81 APE12-dist-in 8.023 APE11-dist-in 11.204 APE10-dist-in 5.808 APE9-dist-in 3.4 L50I,V124M,E128D,Q182K,T184A TPO198,SEP339 TPO198,SEP339 XRAY 2.28 0.201 0.258 A 350 341 0 0 0 0 [[44, 298]] 1.0 2gnf Bos taurus AGC_PRKACA_BOVIN AGC 2.2e-95 324.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GNJA P00517 15 351 351.0 Y27:60501 Type1 Active DFGin 6.104 13.677 BLAminus DFGAsp-rot-in -125.2, 164.0 75.11, 93.42 199.46, -19.02 -104.04, 27.11 286.53, 71.0 -58.19, -29.08 in-in in 9.092 Saltbr-in 2.83 HRD-in -86.57, -53.41 73.77, 21.07 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.71, 163.04 APE9-dihe-na 124.17, -165.73 APE8-dihe-in -116.96, 135.69 APE8-rot-in 293.77 APE67-dihe-in -62.53, -24.27 -43.03, -48.93 APE12-dist-in 8.108 APE11-dist-in 11.319 APE10-dist-in 5.787 APE9-dist-in 3.424 L50I,Q182K,T184A TPO198,SEP339 TPO198,SEP339 XRAY 2.28 0.19 0.262 A 350 337 0 0 0 0 [[44, 298]] 1.0 2gnj Bos taurus AGC_PRKACA_BOVIN AGC 7.5e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2GNLA P00517 12 351 351.0 H52:60501 Type1 Active DFGin 6.358 14.877 BLAminus DFGAsp-rot-in -89.02, -175.74 47.17, 112.42 222.65, -58.48 -122.51, 26.46 259.73, 63.8 -65.5, -20.97 in-in in 9.182 Saltbr-in 2.605 HRD-in -84.16, -63.35 83.4, 16.15 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.63, 164.56 APE9-dihe-na 121.8, -158.16 APE8-dihe-in -125.31, 137.52 APE8-rot-in 295.72 APE67-dihe-in -52.7, -17.18 -53.68, -49.84 APE12-dist-in 8.116 APE11-dist-in 11.522 APE10-dist-in 6.149 APE9-dist-in 3.517 L50I,Q182K,T184A TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.203 0.303 A 350 340 0 0 0 0 [[44, 298]] 1.0 2gnl Bos taurus AGC_PRKACA_BOVIN AGC 7.5e-95 323.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UZTA P00517 16 351 351.0 SS3:61351 Type1 Active DFGin 6.871 14.078 BLAminus DFGAsp-rot-in -126.85, 167.46 69.43, 90.19 189.2, -2.82 -103.99, 29.38 280.49, 66.47 -59.79, -22.48 in-in in 9.14 Saltbr-in 2.691 HRD-in -77.75, -50.42 62.52, 13.49 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.56, 156.36 APE9-dihe-na 116.01, -154.02 APE8-dihe-in -130.0, 127.43 APE8-rot-in 298.59 APE67-dihe-in -60.13, -24.22 -31.54, -56.49 APE12-dist-in 7.83 APE11-dist-in 11.391 APE10-dist-in 5.784 APE9-dist-in 3.724 None None None XRAY 2.1 0.273 0.313 A 336 336 0 0 0 0 [[44, 298]] 1.0 2uzt Bos taurus AGC_PRKACA_BOVIN AGC 1.2e-94 322.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UZUE P00517 16 351 351.0 L20:61351 Type1 Active DFGin 6.516 14.393 BLAminus DFGAsp-rot-in -116.34, 172.4 61.54, 100.04 202.93, -23.31 -109.49, 24.05 269.56, 56.18 -51.88, -19.43 in-in in 8.864 Saltbr-in 2.572 HRD-in -79.6, -53.73 68.74, 6.41 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.25, 159.94 APE9-dihe-na 132.5, -155.2 APE8-dihe-in -127.84, 130.66 APE8-rot-in 306.17 APE67-dihe-in -52.51, -26.75 -31.49, -67.12 APE12-dist-in 7.858 APE11-dist-in 11.172 APE10-dist-in 5.761 APE9-dist-in 3.746 None None None XRAY 2.4 0.318 0.371 E 336 336 0 0 0 0 [[44, 298]] 1.0 2uzu Bos taurus AGC_PRKACA_BOVIN AGC 1.2e-94 322.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UZVA P00517 16 351 351.0 SS5:61351 Type1 Active DFGin 6.794 14.313 BLAminus DFGAsp-rot-in -133.61, 167.29 69.98, 107.83 199.4, -24.4 -122.87, 25.1 278.16, 55.22 -54.77, -25.94 in-in in 9.083 Saltbr-in 2.671 HRD-in -77.51, -58.55 72.39, 6.58 in-in-in SNCiii in-in ActLoopNT-in 3.156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.23, 161.95 APE9-dihe-na 131.29, -149.51 APE8-dihe-in -126.03, 139.69 APE8-rot-in 311.31 APE67-dihe-in -45.96, -25.35 -39.61, -69.13 APE12-dist-in 7.783 APE11-dist-in 11.197 APE10-dist-in 5.837 APE9-dist-in 3.677 None None None XRAY 2.5 0.251 0.316 A 336 336 0 0 0 0 [[44, 298]] 1.0 2uzv Bos taurus AGC_PRKACA_BOVIN AGC 1.2e-94 322.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UZWE P00517 16 351 351.0 SS4:61351 Type1 Active DFGin 6.561 14.574 BLAminus DFGAsp-rot-in -112.04, -173.28 55.73, 87.87 207.5, 8.37 -110.12, 39.6 275.39, 62.8 -71.34, -18.15 in-in in 8.898 Saltbr-in 3.128 HRD-in -78.88, -49.67 62.72, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.16, 162.59 APE9-dihe-na 103.28, -160.9 APE8-dihe-in -116.22, 129.17 APE8-rot-in 310.0 APE67-dihe-in -56.35, -23.35 -31.72, -57.46 APE12-dist-in 8.087 APE11-dist-in 11.353 APE10-dist-in 5.839 APE9-dist-in 3.776 None None None XRAY 2.2 0.313 0.328 E 336 336 0 0 0 0 [[44, 298]] 1.0 2uzw Bos taurus AGC_PRKACA_BOVIN AGC 1.2e-94 322.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q8TA P00517 11 351 351.0 Y27:60930 Type1 Active DFGin 6.185 14.314 BLAminus DFGAsp-rot-in -117.96, 176.23 66.27, 91.07 201.26, -20.1 -99.92, 24.26 275.29, 66.15 -60.05, -23.97 in-in in 9.054 Saltbr-in 2.589 HRD-in -93.15, -51.44 72.41, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.6, 160.94 APE9-dihe-na 131.1, -162.98 APE8-dihe-in -114.15, 135.68 APE8-rot-in 299.16 APE67-dihe-in -56.85, -26.83 -51.6, -49.02 APE12-dist-in 8.177 APE11-dist-in 11.476 APE10-dist-in 5.913 APE9-dist-in 3.689 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.182 0.229 A 350 341 0 0 0 0 [[44, 298]] 1.0 1q8t Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q8WA P00517 15 351 351.0 M77:60960 Type1 Inactive DFGin 6.516 14.691 BLAminus DFGAsp-rot-out -127.81, 164.07 85.37, 88.74 296.72, 50.94 -113.2, 23.58 288.03, 80.25 -50.72, -40.77 in-in in 8.864 Saltbr-in 2.788 HRD-in -88.09, -59.12 85.64, -3.61 in-in-in SNCiii in-in ActLoopNT-in 3.125 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.12, 157.94 APE9-dihe-na 118.72, -168.38 APE8-dihe-in -118.75, 133.72 APE8-rot-in 300.62 APE67-dihe-in -62.19, -20.35 -49.36, -50.33 APE12-dist-in 8.427 APE11-dist-in 11.788 APE10-dist-in 6.4 APE9-dist-in 4.06 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.22 0.295 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q8w Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SVEA P00517 8 351 351.0 I01:60351 Type1 Inactive DFGin 6.166 14.222 BLAminus DFGAsp-rot-out -113.6, -176.53 62.78, 78.1 304.83, -84.99 -100.84, 17.81 278.73, 68.66 -48.01, -28.95 in-in in 8.666 Saltbr-in 2.57 HRD-in -91.7, -56.06 76.75, 8.37 in-in-in SNCiii in-in ActLoopNT-in 3.066 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.08, 161.63 APE9-dihe-na 125.64, -173.88 APE8-dihe-in -102.65, 133.23 APE8-rot-in 299.26 APE67-dihe-in -60.18, -26.54 -47.49, -48.66 APE12-dist-in 8.123 APE11-dist-in 11.455 APE10-dist-in 5.942 APE9-dist-in 3.541 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.49 0.202 0.257 A 350 344 0 0 0 0 [[44, 298]] 1.0 1sve Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SVGA P00517 11 351 351.0 I04:60351 Type1 Inactive DFGin 6.285 14.197 BLAminus DFGAsp-rot-out -126.54, 177.16 64.26, 73.95 281.29, -7.96 -91.56, 21.32 279.08, 73.3 -61.43, -19.1 in-in in 8.581 Saltbr-in 2.681 HRD-in -92.74, -53.98 73.19, 8.88 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.17, 160.9 APE9-dihe-na 123.57, -169.23 APE8-dihe-in -108.56, 130.67 APE8-rot-in 293.73 APE67-dihe-in -66.93, -24.48 -43.76, -46.84 APE12-dist-in 8.091 APE11-dist-in 11.539 APE10-dist-in 6.052 APE9-dist-in 3.648 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.02 0.183 0.227 A 350 341 0 0 0 0 [[44, 298]] 1.0 1svg Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1VEBA P00517 11 351 351.0 I05:60351 Type1 Inactive DFGin 6.213 14.236 BLAminus DFGAsp-rot-out -112.2, -169.65 49.77, 80.02 302.93, 66.12 -102.5, 31.57 278.86, 61.26 -72.56, -20.75 in-in in 8.577 Saltbr-in 2.873 HRD-in -83.01, -49.6 62.13, 5.25 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.53, 158.22 APE9-dihe-na 134.18, -167.65 APE8-dihe-in -109.96, 136.58 APE8-rot-in 290.96 APE67-dihe-in -71.75, -2.37 -42.82, -49.75 APE12-dist-in 8.178 APE11-dist-in 11.679 APE10-dist-in 6.06 APE9-dist-in 3.737 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.89 0.187 0.251 A 350 341 0 0 0 0 [[44, 298]] 1.0 1veb Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH4A P00517 15 351 351.0 R69:60351 Type1 Inactive DFGin 6.297 13.619 BLAminus DFGAsp-rot-out -125.63, 176.59 60.0, 74.66 281.54, -9.73 -89.7, 21.14 287.64, 81.0 -57.7, -30.21 in-in in 8.755 Saltbr-in 2.57 HRD-in -85.89, -55.59 71.5, 15.27 in-in-in SNCiii in-in ActLoopNT-in 3.067 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.1, 158.39 APE9-dihe-na 135.4, -175.25 APE8-dihe-in -99.1, 130.32 APE8-rot-in 300.14 APE67-dihe-in -53.15, -30.05 -47.58, -48.79 APE12-dist-in 8.129 APE11-dist-in 11.585 APE10-dist-in 6.037 APE9-dist-in 3.718 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.45 0.191 0.242 A 350 337 0 0 0 0 [[44, 298]] 1.0 1xh4 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH5A P00517 15 351 351.0 R68:61001 Type1 Inactive DFGin 6.395 13.232 BLAminus DFGAsp-rot-out -125.11, 175.33 63.85, 75.87 281.71, -20.31 -93.6, 21.14 294.45, 75.91 -54.91, -25.56 in-in in 8.735 Saltbr-in 2.738 HRD-in -92.22, -50.1 68.22, 14.89 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.82, 159.18 APE9-dihe-na 129.26, -172.93 APE8-dihe-in -106.77, 134.87 APE8-rot-in 299.04 APE67-dihe-in -60.66, -25.82 -46.87, -48.0 APE12-dist-in 7.951 APE11-dist-in 11.413 APE10-dist-in 5.881 APE9-dist-in 3.591 None TPO198,SEP339 TPO198,SEP339 XRAY 2.05 0.185 0.236 A 350 337 0 0 0 0 [[44, 298]] 1.0 1xh5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH6A P00517 19 351 351.0 R94:60351 Type1 Inactive DFGin 6.128 13.379 BLAminus DFGAsp-rot-out -130.28, 176.51 62.64, 74.17 275.81, -12.81 -91.5, 20.79 288.12, 76.57 -51.25, -30.79 in-in in 8.819 Saltbr-in 2.708 HRD-in -82.23, -52.65 67.28, 14.23 in-in-in SNCiii in-in ActLoopNT-in 3.071 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 161.1 APE9-dihe-na 129.62, -161.03 APE8-dihe-in -117.21, 135.0 APE8-rot-in 298.01 APE67-dihe-in -59.91, -22.98 -46.35, -48.26 APE12-dist-in 8.104 APE11-dist-in 11.501 APE10-dist-in 5.906 APE9-dist-in 3.489 None TPO198,SEP339 TPO198,SEP339 XRAY 1.9 0.192 0.249 A 350 333 0 0 0 0 [[44, 298]] 1.0 1xh6 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH7A P00517 11 351 351.0 R96:60351 Type1 Inactive DFGin 6.383 13.302 BLAminus DFGAsp-rot-out -121.57, 176.46 64.46, 76.56 283.84, -21.86 -95.28, 25.2 293.04, 73.78 -55.65, -33.0 in-in in 8.663 Saltbr-in 2.679 HRD-in -88.46, -51.77 72.39, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.76, 163.97 APE9-dihe-na 129.5, -170.45 APE8-dihe-in -100.96, 130.84 APE8-rot-in 305.54 APE67-dihe-in -56.25, -25.46 -42.72, -53.32 APE12-dist-in 7.989 APE11-dist-in 11.711 APE10-dist-in 6.044 APE9-dist-in 3.92 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.47 0.192 0.254 A 350 341 0 0 0 0 [[44, 298]] 1.0 1xh7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH8A P00517 13 351 351.0 R55:60351 Type1 Inactive DFGin 7.22 14.551 BLAminus DFGAsp-rot-out -127.78, 170.11 66.78, 76.25 281.38, -8.41 -93.48, 35.64 282.0, 79.13 -69.55, -13.04 in-in in 8.665 Saltbr-in 2.585 HRD-in -73.67, -49.45 69.2, 1.69 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.86, 150.19 APE9-dihe-na 125.99, -169.91 APE8-dihe-in -111.55, 132.51 APE8-rot-in 296.34 APE67-dihe-in -62.89, -22.39 -42.71, -52.56 APE12-dist-in 8.791 APE11-dist-in 11.805 APE10-dist-in 6.255 APE9-dist-in 3.512 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.202 0.236 A 350 339 0 0 0 0 [[44, 298]] 1.0 1xh8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3KKVA P00517 14 351 351.0 B99:60351 Type1 Active DFGin 6.28 14.987 BLAminus DFGAsp-rot-in -125.37, 172.94 64.41, 88.24 194.2, -1.59 -101.41, 28.77 274.35, 61.51 -57.52, -30.45 in-in in 9.39 Saltbr-in 2.668 HRD-in -87.09, -58.29 72.04, 20.78 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.6, 161.14 APE9-dihe-na 126.5, -157.51 APE8-dihe-in -121.76, 131.58 APE8-rot-in 301.24 APE67-dihe-in -59.26, -23.73 -39.89, -55.55 APE12-dist-in 7.986 APE11-dist-in 11.251 APE10-dist-in 5.773 APE9-dist-in 3.484 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.8 0.203 0.225 A 350 338 0 0 0 0 [[44, 298]] 1.0 3kkv Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4IJ9A P00517 15 351 351.0 PTV:60401 Type1 Inactive DFGin 6.615 14.131 BLAminus DFGAsp-rot-out -111.94, -175.65 58.73, 79.19 303.82, -18.47 -93.36, 11.75 269.03, 67.58 -54.32, -24.02 in-in in 8.867 Saltbr-in 3.402 HRD-in -79.91, -51.1 66.03, 1.36 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.66, 160.33 APE9-dihe-na 124.74, -169.36 APE8-dihe-in -102.85, 129.95 APE8-rot-in 307.44 APE67-dihe-in -60.51, -31.49 -37.15, -49.85 APE12-dist-in 8.23 APE11-dist-in 11.481 APE10-dist-in 5.81 APE9-dist-in 3.338 None TPO198,SEP339 TPO198,SEP339 XRAY 2.55 0.175 0.247 A 350 337 0 0 0 0 [[44, 298]] 1.0 4ij9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2C1AA P00517 15 351 351.0 I5S:61351 Type1 Inactive DFGin 6.298 14.627 BLAminus DFGAsp-rot-out -124.46, -169.61 66.48, 66.45 277.53, -88.79 -85.13, 21.14 273.21, 64.57 -65.03, -22.49 in-in in 9.003 Saltbr-in 2.612 HRD-in -90.18, -53.0 74.43, 14.23 in-in-in SNCiii in-in ActLoopNT-in 2.97 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.63, 158.7 APE9-dihe-na 138.5, -149.83 APE8-dihe-in -130.06, 134.27 APE8-rot-in 299.96 APE67-dihe-in -59.41, -28.42 -45.36, -49.19 APE12-dist-in 7.848 APE11-dist-in 11.246 APE10-dist-in 5.74 APE9-dist-in 3.561 None TPO198,SEP339 TPO198,SEP339 XRAY 1.95 0.176 0.23 A 351 337 0 0 0 0 [[44, 298]] 1.0 2c1a Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2C1BA P00517 15 351 351.0 CQP:61351 Type1 Active DFGin 6.018 14.576 BLAminus DFGAsp-rot-in -127.46, 168.13 73.41, 94.26 210.63, -43.0 -102.97, 22.93 271.29, 59.53 -60.22, -28.98 in-in in 8.86 Saltbr-in 2.6 HRD-in -86.97, -55.45 75.34, 13.69 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.15, 165.93 APE9-dihe-na 130.88, -155.25 APE8-dihe-in -127.93, 130.25 APE8-rot-in 296.49 APE67-dihe-in -57.75, -24.32 -42.11, -51.87 APE12-dist-in 8.026 APE11-dist-in 11.266 APE10-dist-in 5.72 APE9-dist-in 3.469 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.162 0.211 A 351 337 0 0 0 0 [[44, 298]] 1.0 2c1b Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2F7EE P00517 16 351 351.0 2EA:60351 Type1 Active DFGin 6.426 14.622 BLAminus DFGAsp-rot-in -129.37, 172.24 65.85, 87.0 202.54, -14.01 -103.27, 28.23 271.13, 52.64 -61.39, -20.95 in-in in 9.019 Saltbr-in 2.572 HRD-in -84.54, -55.3 68.58, 20.0 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 149.46 APE9-dihe-na 134.17, -155.82 APE8-dihe-in -124.14, 133.58 APE8-rot-in 298.87 APE67-dihe-in -58.46, -26.82 -32.03, -63.88 APE12-dist-in 7.844 APE11-dist-in 11.246 APE10-dist-in 5.669 APE9-dist-in 3.741 None None None XRAY 2.0 0.283 0.323 E 351 336 0 0 0 0 [[44, 298]] 1.0 2f7e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2F7XE P00517 16 351 351.0 4EA:60351 Type1 Active DFGin 6.479 14.443 BLAminus DFGAsp-rot-in -134.55, -177.23 60.89, 80.89 199.94, -26.86 -96.41, 28.1 269.37, 55.24 -56.5, -28.29 in-in in 8.914 Saltbr-in 2.458 HRD-in -81.93, -53.89 61.67, 20.58 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.99, 155.02 APE9-dihe-na 135.32, -157.56 APE8-dihe-in -123.89, 130.78 APE8-rot-in 298.61 APE67-dihe-in -49.48, -26.89 -30.62, -70.43 APE12-dist-in 7.98 APE11-dist-in 11.406 APE10-dist-in 5.942 APE9-dist-in 3.933 None None None XRAY 1.9 0.268 0.297 E 351 336 0 0 0 0 [[44, 298]] 1.0 2f7x Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2F7ZE P00517 16 351 351.0 6EA:61000 Type1 Active DFGin 6.226 13.955 BLAminus DFGAsp-rot-in -129.55, -167.66 49.24, 93.04 209.07, -32.09 -110.0, 23.76 275.34, 53.4 -53.66, -28.22 in-in in 8.563 Saltbr-in 3.064 HRD-in -65.45, -44.81 59.73, 0.41 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -169.37, 169.07 APE9-dihe-na 126.6, -164.29 APE8-dihe-in -104.93, 138.12 APE8-rot-in 285.38 APE67-dihe-in -37.82, -20.53 -38.18, -81.91 APE12-dist-in 7.836 APE11-dist-in 11.302 APE10-dist-in 6.213 APE9-dist-in 3.724 None None None XRAY 3.0 0.246 0.342 E 351 336 0 0 0 0 [[44, 298]] 1.0 2f7z Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2JDSA P00517 15 351 351.0 L20:61351 Type1 Active DFGin 6.298 14.459 BLAminus DFGAsp-rot-in -119.85, 164.76 69.86, 95.65 196.99, -9.66 -106.41, 24.64 270.02, 58.03 -63.42, -24.71 in-in in 8.841 Saltbr-in 2.956 HRD-in -93.07, -49.96 71.48, 12.63 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.76, 158.61 APE9-dihe-na 135.6, -151.18 APE8-dihe-in -131.14, 134.0 APE8-rot-in 299.22 APE67-dihe-in -56.34, -24.22 -43.06, -54.13 APE12-dist-in 7.928 APE11-dist-in 11.291 APE10-dist-in 5.766 APE9-dist-in 3.506 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.211 0.272 A 351 337 0 0 0 0 [[44, 298]] 1.0 2jds Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2OH0E P00517 16 351 351.0 2PY:60351 Type1 Active DFGin 6.513 14.653 BLAminus DFGAsp-rot-in -127.37, 173.11 66.58, 90.68 205.55, -15.34 -104.37, 27.73 269.87, 52.25 -56.81, -28.64 in-in in 8.929 Saltbr-in 2.582 HRD-in -77.86, -55.61 71.73, 4.87 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.82, 160.53 APE9-dihe-na 132.23, -161.93 APE8-dihe-in -120.81, 133.78 APE8-rot-in 295.17 APE67-dihe-in -53.8, -16.59 -31.38, -69.24 APE12-dist-in 7.877 APE11-dist-in 11.197 APE10-dist-in 5.839 APE9-dist-in 3.674 None None None XRAY 2.2 0.273 0.32 E 351 336 0 0 0 0 [[44, 298]] 1.0 2oh0 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2OJFE P00517 16 351 351.0 4PY:61000 Type1 Active DFGin 6.632 13.575 BLAminus DFGAsp-rot-in -129.09, 175.09 60.55, 94.36 197.99, -9.44 -110.26, 30.25 290.83, 66.47 -61.76, -22.5 in-in in 8.995 Saltbr-in 2.697 HRD-in -83.69, -49.78 65.87, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.63, 160.13 APE9-dihe-na 129.42, -154.83 APE8-dihe-in -123.4, 138.68 APE8-rot-in 295.74 APE67-dihe-in -57.43, -25.96 -38.07, -61.94 APE12-dist-in 7.912 APE11-dist-in 11.272 APE10-dist-in 5.854 APE9-dist-in 3.671 None None None XRAY 2.1 0.265 0.29 E 351 336 0 0 0 0 [[44, 298]] 1.0 2ojf Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3AG9B P00517 16 351 351.0 A02:60351 Type1 Active DFGin 6.707 14.818 BLAminus DFGAsp-rot-in -118.08, 165.29 66.01, 91.25 193.85, -8.77 -100.52, 22.8 270.89, 66.31 -51.41, -38.23 in-in in 9.11 Saltbr-in 2.749 HRD-in -86.2, -49.67 71.39, 4.04 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.38, 133.7 APE9-dihe-na 131.92, -165.0 APE8-dihe-in -83.45, 116.32 APE8-rot-in 314.25 APE67-dihe-in -59.66, -23.97 -46.78, -44.32 APE12-dist-in 8.17 APE11-dist-in 11.919 APE10-dist-in 6.817 APE9-dist-in 5.622 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.23 0.246 B 351 319 0 0 0 0 [[44, 298]] 1.0 3ag9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3ZO1A P00517 10 351 351.0 SIJ:61351 Type1 Inactive DFGin 6.341 14.056 BLAminus DFGAsp-rot-out -119.34, -177.25 63.83, 74.63 290.77, 77.99 -95.99, 18.51 283.99, 75.88 -54.4, -29.22 in-in in 9.104 Saltbr-in 2.663 HRD-in -85.49, -49.19 68.51, 9.51 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.19, 161.74 APE9-dihe-na 124.38, -162.01 APE8-dihe-in -111.99, 135.74 APE8-rot-in 300.86 APE67-dihe-in -57.72, -23.86 -43.38, -54.21 APE12-dist-in 7.999 APE11-dist-in 11.37 APE10-dist-in 5.765 APE9-dist-in 3.444 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.162 0.19 A 351 342 0 0 0 0 [[44, 298]] 1.0 3zo1 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3ZO4A P00517 15 351 351.0 QWI:61352 Type1 Inactive DFGin 5.971 14.432 BLAminus DFGAsp-rot-out -122.52, 179.4 62.97, 87.47 286.25, 57.55 -105.16, 25.03 272.68, 69.84 -56.89, -28.47 in-in in 8.807 Saltbr-in 2.679 HRD-in -83.14, -51.38 69.84, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.86, 163.63 APE9-dihe-na 121.61, -161.92 APE8-dihe-in -113.3, 134.36 APE8-rot-in 304.88 APE67-dihe-in -60.74, -25.7 -43.03, -50.51 APE12-dist-in 8.178 APE11-dist-in 11.51 APE10-dist-in 5.91 APE9-dist-in 3.466 None TPO198,SEP339 TPO198,SEP339 XRAY 1.65 0.17 0.195 A 351 337 0 0 0 0 [[44, 298]] 1.0 3zo4 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4IE9A P00517 15 351 351.0 PZX:60401 Type1 Active DFGin 6.44 14.572 BLAminus DFGAsp-rot-in -120.62, 176.92 66.27, 86.77 207.36, -32.25 -100.95, 18.69 270.67, 65.37 -56.43, -28.52 in-in in 8.916 Saltbr-in 2.77 HRD-in -89.08, -49.96 64.8, 10.82 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 154.28 APE9-dihe-na 136.57, -156.42 APE8-dihe-in -117.79, 131.56 APE8-rot-in 300.22 APE67-dihe-in -56.73, -26.63 -41.25, -54.98 APE12-dist-in 8.177 APE11-dist-in 11.384 APE10-dist-in 5.818 APE9-dist-in 3.663 None TPO198,SEP339 TPO198,SEP339 XRAY 1.92 0.18 0.232 A 351 337 0 0 0 0 [[44, 298]] 1.0 4ie9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 5VHBA P00517 19 351 351.0 9CY:60401 Type1 Active DFGin 5.891 14.41 BLAminus DFGAsp-rot-in -119.66, -177.23 60.94, 80.11 197.81, -7.36 -93.35, 23.41 272.21, 58.28 -59.14, -26.18 in-in in 9.029 Saltbr-in 2.712 HRD-in -91.92, -50.82 66.2, 13.96 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.84, 154.36 APE9-dihe-na 131.28, -165.28 APE8-dihe-in -112.93, 137.33 APE8-rot-in 299.96 APE67-dihe-in -60.22, -22.29 -46.36, -53.5 APE12-dist-in 7.96 APE11-dist-in 11.458 APE10-dist-in 5.827 APE9-dist-in 3.865 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.61 0.178 0.204 A 351 328 0 0 0 0 [[44, 298]] 1.0 5vhb Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 6E99A P00517 19 351 351.0 J0G:60601 Type1 Active DFGin 6.002 14.689 BLAminus DFGAsp-rot-in -119.91, 176.13 61.41, 87.48 197.99, -10.93 -95.36, 20.23 270.62, 61.24 -51.17, -35.89 in-in in 9.209 Saltbr-in 2.774 HRD-in -83.71, -54.36 68.2, 17.2 in-in-in SNCiii in-in ActLoopNT-in 3.028 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.66, 157.43 APE9-dihe-na 126.17, -162.46 APE8-dihe-in -111.15, 131.88 APE8-rot-in 301.0 APE67-dihe-in -61.67, -24.67 -45.52, -49.68 APE12-dist-in 8.114 APE11-dist-in 11.602 APE10-dist-in 5.881 APE9-dist-in 3.762 None TPO198,SEP339 TPO198,SEP339 XRAY 1.88 0.208 0.23 A 351 333 0 0 0 0 [[44, 298]] 1.0 6e99 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 6E9LA P00517 18 351 351.0 J0P:60401 Type1 Active DFGin 6.499 14.403 BLAminus DFGAsp-rot-in -98.87, -153.44 32.95, 78.78 221.45, -36.57 -89.6, 15.58 275.81, 59.68 -55.89, -23.51 in-in in 8.873 Saltbr-in 2.766 HRD-in -69.86, -50.02 57.75, 17.6 in-in-in SNCiii in-in ActLoopNT-in 3.036 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.26, 159.36 APE9-dihe-na 132.47, -166.61 APE8-dihe-in -110.57, 132.03 APE8-rot-in 295.04 APE67-dihe-in -57.99, -24.14 -37.74, -55.31 APE12-dist-in 7.995 APE11-dist-in 11.766 APE10-dist-in 6.194 APE9-dist-in 4.072 None TPO198,SEP339 TPO198,SEP339 XRAY 2.8 0.198 0.271 A 351 334 0 0 0 0 [[44, 298]] 1.0 6e9l Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 8SF8A P00517 13 351 351.0 ZWG:60401 Type1 Active DFGin 6.28 14.254 BLAminus DFGAsp-rot-in -129.1, 170.06 68.03, 97.5 203.78, -29.21 -109.47, 25.84 272.72, 61.91 -63.1, -22.98 in-in in 8.751 Saltbr-in 2.756 HRD-in -95.34, -49.3 69.01, 11.41 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.49, 160.11 APE9-dihe-na 135.6, -161.4 APE8-dihe-in -120.07, 137.81 APE8-rot-in 299.35 APE67-dihe-in -59.91, -22.91 -50.11, -49.66 APE12-dist-in 8.079 APE11-dist-in 11.247 APE10-dist-in 5.82 APE9-dist-in 3.533 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.199 0.22 A 353 339 0 0 0 0 [[44, 298]] 1.0 8sf8 Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3DNDA P00517 16 351 351.0 LL2:60351 Type1 Active DFGin 6.544 14.635 BLAminus DFGAsp-rot-in -116.16, 171.46 66.82, 93.02 212.87, -38.93 -101.85, 16.18 271.74, 55.59 -52.63, -24.52 in-in in 9.186 Saltbr-in 2.958 HRD-in -95.42, -56.13 76.88, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.6, 159.85 APE9-dihe-na 129.5, -152.83 APE8-dihe-in -125.57, 136.21 APE8-rot-in 298.43 APE67-dihe-in -52.95, -28.96 -44.81, -53.93 APE12-dist-in 8.06 APE11-dist-in 11.378 APE10-dist-in 5.823 APE9-dist-in 3.437 None TPO198,SEP339 TPO198,SEP339 XRAY 2.26 0.19 0.253 A 350 336 0 0 0 0 [[44, 298]] 1.0 3dnd Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3DNEA P00517 14 351 351.0 LL1:60351 Type1 Inactive DFGin 6.437 14.459 BLAminus DFGAsp-rot-out -121.1, -178.57 64.95, 70.37 288.33, -2.89 -87.98, 19.34 273.67, 65.23 -66.31, -20.97 in-in in 8.819 Saltbr-in 2.735 HRD-in -96.15, -42.67 61.27, 10.37 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.64, 165.13 APE9-dihe-na 129.71, -157.6 APE8-dihe-in -124.5, 137.89 APE8-rot-in 294.27 APE67-dihe-in -60.97, -25.49 -45.94, -52.87 APE12-dist-in 8.059 APE11-dist-in 11.164 APE10-dist-in 5.718 APE9-dist-in 3.529 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.179 0.23 A 350 338 0 0 0 0 [[44, 298]] 1.0 3dne Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4YXRA P00517 16 351 351.0 0RW:60401 Type1 Active DFGin 6.009 14.295 BLAminus DFGAsp-rot-in -119.04, 170.91 66.3, 93.05 204.54, -14.21 -106.53, 24.67 276.07, 60.12 -58.07, -27.2 in-in in 9.001 Saltbr-in 2.701 HRD-in -82.28, -52.44 64.39, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.51, 157.24 APE9-dihe-na 130.59, -154.35 APE8-dihe-in -122.35, 133.27 APE8-rot-in 301.51 APE67-dihe-in -58.69, -25.56 -33.6, -61.81 APE12-dist-in 8.011 APE11-dist-in 11.363 APE10-dist-in 5.849 APE9-dist-in 3.637 None TPO198,SEP339 TPO198,SEP339 XRAY 2.0 999.0 0.252 A 350 336 0 0 0 0 [[44, 298]] 1.0 4yxr Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4YXSA P00517 15 351 351.0 EMU:60401 Type1 Active DFGin 6.286 13.594 BLAminus DFGAsp-rot-in -119.26, 168.5 67.4, 97.14 195.76, -20.1 -108.4, 23.82 281.89, 73.4 -58.43, -25.53 in-in in 8.661 Saltbr-in 2.64 HRD-in -81.58, -52.24 65.52, 13.45 in-in-in SNCiii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.78, 159.45 APE9-dihe-na 131.68, -155.75 APE8-dihe-in -118.67, 131.09 APE8-rot-in 300.67 APE67-dihe-in -60.75, -29.57 -37.55, -53.5 APE12-dist-in 7.938 APE11-dist-in 11.274 APE10-dist-in 5.702 APE9-dist-in 3.617 None TPO198,SEP339 TPO198,SEP339 XRAY 2.11 0.179 0.232 A 350 337 0 0 0 0 [[44, 298]] 1.0 4yxs Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1YDRE P00517 16 351 351.0 IQP:60351 Type1 Active DFGin 6.329 14.25 BLAminus DFGAsp-rot-in -123.41, -178.28 58.45, 85.19 199.21, -3.68 -101.97, 32.19 283.4, 54.35 -61.44, -27.25 in-in in 9.05 Saltbr-in 2.785 HRD-in -72.07, -64.76 83.06, 0.73 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.65, 168.03 APE9-dihe-na 116.01, -166.19 APE8-dihe-in -108.88, 132.42 APE8-rot-in 303.05 APE67-dihe-in -60.22, -26.51 -39.35, -52.68 APE12-dist-in 7.871 APE11-dist-in 11.298 APE10-dist-in 5.896 APE9-dist-in 3.752 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.188 999.0 E 350 336 0 0 0 0 [[44, 298]] 1.0 1ydr Bos taurus AGC_PRKACA_BOVIN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1YDSE P00517 16 351 351.0 IQS:60351 Type1 Inactive DFGin 6.39 14.288 BLAminus DFGAsp-rot-out -112.84, -174.99 60.37, 74.83 308.27, -87.35 -97.86, 29.16 279.73, 63.74 -63.98, -20.15 in-in in 8.937 Saltbr-in 2.776 HRD-in -75.45, -57.26 74.03, 4.96 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.17, 169.02 APE9-dihe-na 97.73, -165.42 APE8-dihe-in -112.69, 125.84 APE8-rot-in 302.88 APE67-dihe-in -57.81, -27.95 -31.43, -56.99 APE12-dist-in 7.941 APE11-dist-in 11.185 APE10-dist-in 5.738 APE9-dist-in 3.608 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.199 999.0 E 350 336 0 0 0 0 [[44, 298]] 1.0 1yds Bos taurus AGC_PRKACA_BOVIN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1YDTE P00517 16 351 351.0 IQB:60351 Type1 Active DFGin 6.562 14.574 BLAminus DFGAsp-rot-in -112.01, -173.33 55.77, 87.81 207.52, 8.44 -110.08, 39.59 275.46, 62.76 -71.4, -18.08 in-in in 8.898 Saltbr-in 3.127 HRD-in -78.94, -49.64 62.76, 12.37 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.17, 162.58 APE9-dihe-na 103.22, -160.88 APE8-dihe-in -116.29, 129.25 APE8-rot-in 310.0 APE67-dihe-in -56.34, -23.41 -31.82, -57.38 APE12-dist-in 8.088 APE11-dist-in 11.353 APE10-dist-in 5.838 APE9-dist-in 3.776 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.194 999.0 E 350 336 0 0 0 0 [[44, 298]] 1.0 1ydt Bos taurus AGC_PRKACA_BOVIN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SZMA P00517 16 351 351.0 BI4:60351 Type1 Active DFGin 6.318 15.368 BLAminus DFGAsp-rot-in -125.27, 171.81 65.17, 99.61 212.59, -33.5 -108.03, 19.56 272.67, 80.44 -58.01, -35.62 in-in in 9.492 Saltbr-in 2.574 HRD-in -86.5, -61.07 68.65, 7.7 in-in-in SNCiii in-in ActLoopNT-in 3.003 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.54, 163.31 APE9-dihe-na 107.11, 170.89 APE8-dihe-in -74.89, 129.09 APE8-rot-in 328.61 APE67-dihe-in -51.73, -30.1 -54.41, -49.2 APE12-dist-in 8.04 APE11-dist-in 11.33 APE10-dist-in 5.763 APE9-dist-in 3.806 V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.5 0.234 0.289 A 350 320 0 0 0 0 [[44, 298]] 1.0 1szm Bos taurus AGC_PRKACA_BOVIN AGC 1.7e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4Z84A P00517 15 351 351.0 NVX:60401 Type1 Inactive DFGin 6.154 14.585 BLAminus DFGAsp-rot-out -122.35, -175.47 64.09, 72.13 303.82, -31.11 -88.27, 20.06 271.08, 58.42 -49.77, -31.82 in-in in 9.016 Saltbr-in 2.799 HRD-in -96.48, -53.57 76.53, 13.57 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.06, 154.73 APE9-dihe-na 134.03, -158.23 APE8-dihe-in -120.28, 132.43 APE8-rot-in 300.75 APE67-dihe-in -53.91, -23.24 -46.29, -52.23 APE12-dist-in 8.15 APE11-dist-in 11.524 APE10-dist-in 5.925 APE9-dist-in 3.511 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.554 0.209 0.234 A 351 337 0 0 0 0 [[44, 298]] 1.0 4z84 Bos taurus AGC_PRKACA_BOVIN AGC 1.7e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XHAA P00517 2 351 351.0 R68:61001 Type1 Inactive DFGin 6.264 14.137 BLAminus DFGAsp-rot-out -120.5, -174.91 64.53, 71.29 276.47, -9.51 -89.72, 23.88 279.31, 73.73 -56.55, -38.89 in-in in 8.737 Saltbr-in 2.545 HRD-in -89.15, -49.54 68.47, 12.55 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.3, 164.66 APE9-dihe-na 127.73, 179.02 APE8-dihe-in -85.45, 132.2 APE8-rot-in 302.59 APE67-dihe-in -55.5, -36.01 -41.3, -53.29 APE12-dist-in 8.465 APE11-dist-in 11.779 APE10-dist-in 6.157 APE9-dist-in 3.747 Q85E,V124A,L174M,F188L TPO198,SEP339 TPO198,SEP339 XRAY 2.46 0.223 0.272 A 350 350 0 0 0 0 [[44, 298]] 1.0 1xha Bos taurus AGC_PRKACA_BOVIN AGC 3.1e-94 321.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2JDTA P00517 16 351 351.0 I5S:61351 Type1 Inactive DFGin 6.248 14.454 BLAminus DFGAsp-rot-out -118.34, -171.87 56.8, 75.79 284.67, 82.78 -95.64, 21.06 274.55, 57.92 -54.25, -28.4 in-in in 8.841 Saltbr-in 2.727 HRD-in -87.26, -55.39 77.73, 12.38 in-in-in SNCiii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.35, 160.37 APE9-dihe-na 136.22, -156.91 APE8-dihe-in -125.95, 134.07 APE8-rot-in 299.88 APE67-dihe-in -54.81, -22.83 -45.72, -53.17 APE12-dist-in 7.96 APE11-dist-in 11.376 APE10-dist-in 5.79 APE9-dist-in 3.546 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.15 0.203 0.259 A 351 336 0 0 0 0 [[44, 298]] 1.0 2jdt Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2JDVA P00517 16 351 351.0 L20:61351 Type1 Active DFGin 6.891 13.82 BLAminus DFGAsp-rot-in -131.77, 167.29 66.94, 91.79 195.52, -20.78 -105.86, 27.67 278.62, 60.56 -53.86, -24.56 in-in in 8.841 Saltbr-in 2.878 HRD-in -94.92, -55.32 76.45, 14.41 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.28, 166.03 APE9-dihe-na 121.76, -153.88 APE8-dihe-in -130.57, 133.66 APE8-rot-in 294.95 APE67-dihe-in -54.68, -28.08 -47.57, -51.85 APE12-dist-in 8.003 APE11-dist-in 11.385 APE10-dist-in 5.781 APE9-dist-in 3.419 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.08 0.21 0.276 A 351 336 0 0 0 0 [[44, 298]] 1.0 2jdv Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UVXA P00517 15 351 351.0 GVH:61351 Type1 Active DFGin 6.48 13.852 BLAminus DFGAsp-rot-in -113.02, 171.98 67.75, 90.65 197.73, -17.76 -101.98, 28.22 272.02, 52.69 -58.83, -28.67 in-in in 8.435 Saltbr-in 2.858 HRD-in -88.35, -54.63 73.53, 9.81 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.14, 156.72 APE9-dihe-na 129.39, -155.0 APE8-dihe-in -123.88, 135.4 APE8-rot-in 299.16 APE67-dihe-in -58.73, -23.74 -45.63, -51.62 APE12-dist-in 7.861 APE11-dist-in 11.224 APE10-dist-in 5.696 APE9-dist-in 3.534 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.175 0.237 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uvx Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UVYA P00517 16 351 351.0 GVI:61351 Type1 Active DFGin 6.688 13.73 BLAminus DFGAsp-rot-in -138.26, 177.38 63.89, 90.39 199.57, -24.95 -103.82, 30.2 278.88, 60.78 -58.29, -25.32 in-in in 8.532 Saltbr-in 2.868 HRD-in -91.19, -52.46 73.0, 13.57 in-in-in SNCiii in-in ActLoopNT-in 2.955 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.29, 164.08 APE9-dihe-na 125.27, -164.76 APE8-dihe-in -118.0, 134.0 APE8-rot-in 303.1 APE67-dihe-in -57.9, -24.5 -45.7, -51.96 APE12-dist-in 7.9 APE11-dist-in 11.319 APE10-dist-in 5.731 APE9-dist-in 3.537 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.218 0.253 A 351 336 0 0 0 0 [[44, 298]] 1.0 2uvy Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UVZA P00517 15 351 351.0 GVJ:61351 Type1 Inactive DFGin 6.458 13.957 BLAminus DFGAsp-rot-out -114.74, -176.7 66.06, 78.43 307.02, 89.91 -99.26, 24.12 270.22, 58.52 -59.61, -24.08 in-in in 8.526 Saltbr-in 2.629 HRD-in -92.0, -54.55 74.61, 15.4 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.48, 161.55 APE9-dihe-na 129.65, -159.59 APE8-dihe-in -126.36, 133.57 APE8-rot-in 300.99 APE67-dihe-in -58.07, -24.11 -45.65, -50.65 APE12-dist-in 7.863 APE11-dist-in 11.155 APE10-dist-in 5.646 APE9-dist-in 3.462 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.94 0.205 0.245 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uvz Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW0A P00517 15 351 351.0 GVK:61351 Type1 Active DFGin 6.681 13.854 BLAminus DFGAsp-rot-in -123.12, 170.63 63.31, 92.05 196.99, -13.84 -104.17, 27.62 276.86, 57.75 -54.59, -30.88 in-in in 8.606 Saltbr-in 2.706 HRD-in -91.98, -52.4 71.75, 13.11 in-in-in SNCiii in-in ActLoopNT-in 2.956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.42, 159.97 APE9-dihe-na 125.35, -161.9 APE8-dihe-in -119.06, 132.94 APE8-rot-in 303.5 APE67-dihe-in -59.26, -23.73 -42.54, -53.1 APE12-dist-in 7.95 APE11-dist-in 11.363 APE10-dist-in 5.817 APE9-dist-in 3.571 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.204 0.248 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uw0 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW3A P00517 15 351 351.0 GVG:61351 Type1 Active DFGin 6.512 13.573 BLAminus DFGAsp-rot-in -134.7, 177.07 65.72, 91.81 198.03, -17.01 -107.38, 30.0 281.86, 61.73 -63.9, -19.07 in-in in 8.514 Saltbr-in 2.935 HRD-in -92.24, -48.61 69.34, 10.98 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.62, 157.61 APE9-dihe-na 126.53, -159.5 APE8-dihe-in -119.31, 132.1 APE8-rot-in 301.91 APE67-dihe-in -60.53, -27.24 -45.08, -48.44 APE12-dist-in 7.895 APE11-dist-in 11.296 APE10-dist-in 5.765 APE9-dist-in 3.554 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.19 0.191 0.252 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uw3 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW4A P00517 15 351 351.0 L15:61351 Type1 Active DFGin 6.492 14.011 BLAminus DFGAsp-rot-in -125.98, 178.92 62.3, 87.41 197.89, -11.11 -98.07, 19.83 275.17, 58.86 -56.03, -29.21 in-in in 8.695 Saltbr-in 2.685 HRD-in -99.89, -51.11 66.26, 15.03 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.17, 154.32 APE9-dihe-na 136.7, -157.38 APE8-dihe-in -123.04, 134.76 APE8-rot-in 305.65 APE67-dihe-in -59.99, -23.88 -42.91, -53.6 APE12-dist-in 7.869 APE11-dist-in 11.292 APE10-dist-in 5.818 APE9-dist-in 3.835 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.219 0.274 A 351 336 1 0 0 0 [[44, 298]] 1.0 2uw4 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW5A P00517 16 351 351.0 GVN:61351 Type1 Active DFGin 6.401 13.877 BLAminus DFGAsp-rot-in -133.91, 172.04 65.21, 93.24 197.54, -17.57 -108.15, 25.65 277.97, 62.72 -53.54, -37.02 in-in in 8.728 Saltbr-in 2.806 HRD-in -86.0, -54.55 71.01, 10.44 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.67, 159.27 APE9-dihe-na 130.34, -162.49 APE8-dihe-in -114.97, 133.7 APE8-rot-in 296.24 APE67-dihe-in -62.66, -23.25 -45.46, -47.84 APE12-dist-in 7.9 APE11-dist-in 11.248 APE10-dist-in 5.712 APE9-dist-in 3.569 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.14 0.207 0.259 A 351 336 0 0 0 0 [[44, 298]] 1.0 2uw5 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW6A P00517 15 351 351.0 GVO:61351 Type1 Inactive DFGin 6.537 14.032 BLAminus DFGAsp-rot-out -123.92, -171.55 58.59, 76.44 292.01, -85.81 -99.17, 23.1 278.06, 64.52 -53.95, -28.73 in-in in 8.899 Saltbr-in 2.695 HRD-in -89.32, -52.49 72.51, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 165.8 APE9-dihe-na 120.56, -163.15 APE8-dihe-in -118.84, 134.95 APE8-rot-in 297.85 APE67-dihe-in -59.8, -23.71 -47.39, -48.58 APE12-dist-in 7.946 APE11-dist-in 11.354 APE10-dist-in 5.783 APE9-dist-in 3.504 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.23 0.192 0.244 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uw6 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW7A P00517 15 351 351.0 GVP:61351 Type1 Active DFGin 6.617 13.735 BLAminus DFGAsp-rot-in -136.69, 175.22 59.69, 95.21 200.67, -19.24 -111.12, 31.03 278.38, 57.43 -58.09, -25.49 in-in in 8.561 Saltbr-in 2.709 HRD-in -86.23, -51.08 72.7, 10.78 in-in-in SNCiii in-in ActLoopNT-in 3.02 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.27, 162.23 APE9-dihe-na 121.1, -162.52 APE8-dihe-in -116.53, 136.36 APE8-rot-in 303.46 APE67-dihe-in -55.18, -28.45 -48.94, -51.5 APE12-dist-in 7.93 APE11-dist-in 11.449 APE10-dist-in 5.802 APE9-dist-in 3.514 V105T,V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 2.1 0.239 0.318 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uw7 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2UW8A P00517 15 351 351.0 GVQ:61351 Type1 Active DFGin 6.304 14.28 BLAminus DFGAsp-rot-in -127.77, 173.64 63.87, 90.76 213.35, -39.63 -102.26, 24.27 274.86, 58.11 -57.85, -25.36 in-in in 8.788 Saltbr-in 2.619 HRD-in -87.86, -52.11 70.45, 11.81 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.21, 162.91 APE9-dihe-na 127.4, -162.92 APE8-dihe-in -121.14, 133.97 APE8-rot-in 304.45 APE67-dihe-in -56.86, -24.67 -46.34, -50.57 APE12-dist-in 7.951 APE11-dist-in 11.282 APE10-dist-in 5.775 APE9-dist-in 3.532 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.188 0.233 A 351 337 0 0 0 0 [[44, 298]] 1.0 2uw8 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VNWA P00517 15 351 351.0 M01:61351 Type1 Inactive DFGin 6.52 14.254 BLAminus DFGAsp-rot-out -99.0, -162.5 57.81, 69.82 298.17, -87.47 -93.2, 19.41 267.8, 58.81 -57.89, -28.06 in-in in 8.608 Saltbr-in 2.792 HRD-in -93.79, -52.83 75.12, 12.44 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.21, 164.77 APE9-dihe-na 124.54, -157.72 APE8-dihe-in -125.0, 133.49 APE8-rot-in 299.26 APE67-dihe-in -56.84, -26.04 -43.44, -52.9 APE12-dist-in 7.899 APE11-dist-in 11.306 APE10-dist-in 5.748 APE9-dist-in 3.438 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.09 0.179 0.247 A 351 337 0 0 0 0 [[44, 298]] 1.0 2vnw Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VNYA P00517 15 351 351.0 M02:61351 Type1 Active DFGin 6.502 13.893 BLAminus DFGAsp-rot-in -119.89, 177.02 61.41, 90.56 204.18, -19.72 -103.09, 29.14 278.68, 50.15 -55.55, -28.57 in-in in 8.484 Saltbr-in 2.858 HRD-in -86.58, -53.8 72.94, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 164.15 APE9-dihe-na 124.54, -158.42 APE8-dihe-in -121.16, 130.65 APE8-rot-in 300.17 APE67-dihe-in -57.01, -22.39 -43.28, -52.93 APE12-dist-in 7.921 APE11-dist-in 11.33 APE10-dist-in 5.814 APE9-dist-in 3.478 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.96 0.226 0.292 A 351 337 0 0 0 0 [[44, 298]] 1.0 2vny Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VO3A P00517 15 351 351.0 M04:61352 Type1 Inactive DFGin 6.43 14.418 BLAminus DFGAsp-rot-out -103.33, -162.63 58.24, 61.11 299.55, 78.4 -86.11, 18.5 266.87, 55.84 -51.81, -33.51 in-in in 8.77 Saltbr-in 2.655 HRD-in -94.44, -55.26 74.28, 15.13 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.75, 157.39 APE9-dihe-na 131.99, -148.74 APE8-dihe-in -128.37, 129.57 APE8-rot-in 302.29 APE67-dihe-in -55.2, -26.12 -39.48, -55.25 APE12-dist-in 7.968 APE11-dist-in 11.444 APE10-dist-in 5.858 APE9-dist-in 3.617 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.98 0.189 0.246 A 351 337 0 0 0 0 [[44, 298]] 1.0 2vo3 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VO6A P00517 14 351 351.0 M05:61352 Type1 Active DFGin 6.435 14.187 BLAminus DFGAsp-rot-in -116.69, -177.73 56.84, 84.85 199.0, -9.89 -93.23, 27.76 272.38, 55.86 -61.33, -23.85 in-in in 8.624 Saltbr-in 2.75 HRD-in -94.44, -52.03 70.59, 14.63 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.43, 161.66 APE9-dihe-na 131.96, -159.34 APE8-dihe-in -122.22, 131.28 APE8-rot-in 303.11 APE67-dihe-in -58.4, -24.83 -41.37, -51.96 APE12-dist-in 7.998 APE11-dist-in 11.321 APE10-dist-in 5.797 APE9-dist-in 3.578 V105T,V124A,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.97 0.175 0.229 A 351 338 0 0 0 0 [[44, 298]] 1.0 2vo6 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C36A P00517 14 351 351.0 ZO9:61351 Type1 Active DFGin 6.181 14.476 BLAminus DFGAsp-rot-in -118.69, 178.88 60.12, 90.41 208.77, -11.55 -102.76, 21.93 269.17, 67.05 -52.26, -31.89 in-in in 8.958 Saltbr-in 2.752 HRD-in -81.95, -52.55 68.64, 5.14 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.13, 158.34 APE9-dihe-na 127.36, -163.94 APE8-dihe-in -108.9, 133.1 APE8-rot-in 299.72 APE67-dihe-in -56.07, -28.95 -40.56, -54.07 APE12-dist-in 8.142 APE11-dist-in 11.457 APE10-dist-in 5.838 APE9-dist-in 3.537 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.98 0.158 0.19 A 351 338 0 0 0 0 [[44, 298]] 1.0 4c36 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C38A P00517 15 351 351.0 VUP:61351 Type1 Active DFGin 6.222 14.405 BLAminus DFGAsp-rot-in -126.62, 165.92 74.69, 93.13 194.67, -3.34 -106.33, 26.68 268.54, 56.88 -59.81, -19.94 in-in in 8.772 Saltbr-in 2.712 HRD-in -83.07, -52.03 71.32, 8.89 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.52, 161.58 APE9-dihe-na 127.55, -160.47 APE8-dihe-in -120.22, 132.35 APE8-rot-in 299.09 APE67-dihe-in -60.14, -23.8 -44.31, -50.86 APE12-dist-in 8.074 APE11-dist-in 11.451 APE10-dist-in 5.834 APE9-dist-in 3.506 F55Y,M121L,V124L,L174M,Q182K SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.58 0.154 0.178 A 351 337 0 0 0 0 [[44, 298]] 1.0 4c38 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q8UA P00517 8 351 351.0 H52:60961,H52:60962 Type1,Allosteric Active DFGin 6.192 14.54 BLAminus DFGAsp-rot-in -121.34, -175.23 53.4, 94.64 209.27, -24.62 -107.06, 23.52 275.18, 66.66 -55.71, -29.87 in-in in 9.365 Saltbr-in 2.65 HRD-in -94.99, -53.62 73.43, 4.82 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.92, 158.63 APE9-dihe-na 129.17, -156.38 APE8-dihe-in -121.51, 130.86 APE8-rot-in 299.83 APE67-dihe-in -61.21, -26.61 -47.69, -47.6 APE12-dist-in 8.207 APE11-dist-in 11.549 APE10-dist-in 5.967 APE9-dist-in 3.647 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.9 0.173 0.206 A 350 344 0 0 0 0 [[44, 298]] 1.0 1q8u Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3BWJA P00517 11 351 351.0 ARX:60351,ARX:60352 Type1,Allosteric Active DFGin 6.696 14.407 BLAminus DFGAsp-rot-in -110.43, 169.36 68.32, 91.4 201.18, -14.62 -103.19, 23.79 279.15, 62.0 -69.5, -7.66 in-in in 8.665 Saltbr-in 2.72 HRD-in -86.31, -55.51 71.76, 12.05 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.81, 155.85 APE9-dihe-na 142.65, -162.5 APE8-dihe-in -110.95, 130.57 APE8-rot-in 293.64 APE67-dihe-in -63.27, -21.79 -42.33, -48.7 APE12-dist-in 8.115 APE11-dist-in 11.378 APE10-dist-in 5.921 APE9-dist-in 3.735 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.201 0.249 A 350 341 0 0 0 0 [[44, 298]] 1.0 3bwj Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4Z83E P00517 15 351 351.0 4L7:60401,4L7:60402 Type1,Allosteric Inactive DFGin 5.989 14.573 BLAminus DFGAsp-rot-out -130.13, -162.52 52.5, 73.8 307.4, -32.69 -91.1, 22.2 271.01, 60.02 -56.14, -30.3 in-in in 8.96 Saltbr-in 2.616 HRD-in -86.75, -50.89 68.08, 10.37 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.2, 158.26 APE9-dihe-na 130.71, -157.52 APE8-dihe-in -119.41, 132.79 APE8-rot-in 303.19 APE67-dihe-in -56.65, -23.66 -45.82, -50.99 APE12-dist-in 8.121 APE11-dist-in 11.496 APE10-dist-in 5.949 APE9-dist-in 3.71 V124A,L174M,Q182K TPO198,SEP339 TPO198,SEP339 XRAY 1.8 0.182 0.217 E 350 337 0 0 0 0 [[44, 298]] 1.0 4z83 Bos taurus AGC_PRKACA_BOVIN AGC 1.7e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 2VO0A P00517 9 351 351.0 M03:61354,M03:61355 Type1,Allosteric Inactive DFGin 6.468 14.435 BLAminus DFGAsp-rot-out -105.06, -163.48 59.05, 63.73 296.52, -86.17 -87.9, 21.77 268.86, 60.16 -61.88, -26.99 in-in in 8.815 Saltbr-in 2.456 HRD-in -97.05, -57.43 76.4, 9.67 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.64, 159.11 APE9-dihe-na 131.22, -153.01 APE8-dihe-in -127.42, 133.63 APE8-rot-in 298.09 APE67-dihe-in -55.96, -25.96 -42.79, -54.49 APE12-dist-in 7.968 APE11-dist-in 11.383 APE10-dist-in 5.899 APE9-dist-in 3.649 V105T,V124A,L174M,Q182K SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.94 0.165 0.216 A 351 343 0 0 0 0 [[44, 298]] 1.0 2vo0 Bos taurus AGC_PRKACA_BOVIN AGC 4.7e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CA P00517 8 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.201 14.443 BLAminus DFGAsp-rot-in -125.76, -178.37 54.76, 79.93 190.19, 10.75 -90.51, 28.04 276.07, 57.76 -61.29, -35.5 in-in in 8.807 Saltbr-in 2.858 HRD-in -85.03, -54.57 65.22, 22.07 in-in-in SNCiii in-in ActLoopNT-in 2.822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.95, 159.1 APE9-dihe-na 118.65, -172.42 APE8-dihe-in -101.75, 128.13 APE8-rot-in 295.06 APE67-dihe-in -58.34, -26.98 -41.06, -49.71 APE12-dist-in 8.092 APE11-dist-in 11.552 APE10-dist-in 6.128 APE9-dist-in 3.911 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 A 350 344 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CB P00517 5 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.532 14.63 BLAminus DFGAsp-rot-in -126.7, -178.91 56.82, 78.03 197.76, -15.79 -91.32, 30.19 275.18, 53.57 -61.25, -34.87 in-in in 8.762 Saltbr-in 3.057 HRD-in -84.6, -55.03 67.66, 19.16 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.35, 159.24 APE9-dihe-na 119.5, -170.09 APE8-dihe-in -105.39, 130.22 APE8-rot-in 303.07 APE67-dihe-in -57.44, -28.07 -44.47, -49.51 APE12-dist-in 8.047 APE11-dist-in 11.524 APE10-dist-in 6.024 APE9-dist-in 3.86 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 B 350 347 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CC P00517 8 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.297 14.756 BLAminus DFGAsp-rot-in -125.92, -177.85 55.25, 79.64 189.96, 8.72 -90.5, 29.38 270.76, 52.31 -60.78, -37.14 in-in in 8.817 Saltbr-in 2.635 HRD-in -82.84, -55.25 65.25, 20.45 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.33, 159.63 APE9-dihe-na 118.14, -173.27 APE8-dihe-in -100.83, 130.06 APE8-rot-in 300.03 APE67-dihe-in -60.34, -24.98 -43.86, -49.06 APE12-dist-in 8.052 APE11-dist-in 11.527 APE10-dist-in 6.082 APE9-dist-in 3.913 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 C 350 344 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CD P00517 5 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.469 14.614 BLAminus DFGAsp-rot-in -125.62, -178.32 56.8, 78.69 198.44, -20.69 -92.33, 30.68 274.67, 61.46 -62.35, -34.64 in-in in 8.798 Saltbr-in 2.657 HRD-in -84.05, -54.95 66.91, 19.26 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.6, 160.31 APE9-dihe-na 118.55, -170.22 APE8-dihe-in -103.2, 129.22 APE8-rot-in 310.88 APE67-dihe-in -59.74, -24.78 -43.75, -49.55 APE12-dist-in 8.092 APE11-dist-in 11.488 APE10-dist-in 6.067 APE9-dist-in 3.881 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 D 350 347 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CE P00517 14 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.486 14.605 BLAminus DFGAsp-rot-in -126.72, -179.02 57.21, 78.54 203.36, -19.52 -91.86, 29.91 275.24, 58.74 -61.76, -34.81 in-in in 8.775 Saltbr-in 2.849 HRD-in -84.14, -54.47 66.34, 19.61 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.41, 160.32 APE9-dihe-na 118.41, -171.62 APE8-dihe-in -103.31, 130.93 APE8-rot-in 316.9 APE67-dihe-in -58.71, -26.13 -46.25, -48.17 APE12-dist-in 8.086 APE11-dist-in 11.519 APE10-dist-in 6.061 APE9-dist-in 3.871 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 E 350 338 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8CF P00517 8 351 351.0 G96:60351 Type1.5_Back Active DFGin 6.204 14.596 BLAminus DFGAsp-rot-in -125.48, -179.37 56.48, 79.11 193.1, -19.92 -90.97, 29.84 273.44, 55.64 -61.95, -35.57 in-in in 8.801 Saltbr-in 2.905 HRD-in -84.03, -54.54 65.26, 20.82 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.83, 160.18 APE9-dihe-na 118.26, -172.77 APE8-dihe-in -101.93, 130.0 APE8-rot-in 316.95 APE67-dihe-in -59.02, -26.57 -43.48, -49.35 APE12-dist-in 8.079 APE11-dist-in 11.495 APE10-dist-in 6.062 APE9-dist-in 3.879 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.265 0.29 F 350 344 0 0 0 0 [[44, 298]] 1.0 3e8c Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EA P00517 8 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.307 14.627 BLAminus DFGAsp-rot-in -127.58, 177.12 59.26, 81.09 196.69, 3.15 -89.3, 24.2 272.49, 51.41 -54.01, -38.82 in-in in 8.623 Saltbr-in 2.617 HRD-in -86.71, -49.98 69.16, 6.49 in-in-in SNCiii in-in ActLoopNT-in 2.863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.99, 154.32 APE9-dihe-na 133.62, -170.54 APE8-dihe-in -106.52, 129.54 APE8-rot-in 301.27 APE67-dihe-in -53.09, -32.91 -42.99, -51.98 APE12-dist-in 8.207 APE11-dist-in 11.482 APE10-dist-in 5.92 APE9-dist-in 3.772 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 A 350 344 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EB P00517 13 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.294 14.718 BLAminus DFGAsp-rot-in -125.84, -172.92 50.21, 81.31 195.82, 3.27 -89.14, 23.18 270.21, 58.55 -50.98, -43.5 in-in in 8.664 Saltbr-in 2.665 HRD-in -82.38, -53.17 68.54, 5.22 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.38, 161.75 APE9-dihe-na 128.75, -165.32 APE8-dihe-in -112.15, 133.4 APE8-rot-in 300.5 APE67-dihe-in -58.46, -24.04 -42.84, -57.3 APE12-dist-in 8.098 APE11-dist-in 11.349 APE10-dist-in 5.822 APE9-dist-in 3.724 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 B 350 339 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EE P00517 8 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.502 14.714 BLAminus DFGAsp-rot-in -125.94, 177.63 60.28, 78.38 196.68, -1.13 -89.05, 26.68 272.68, 53.04 -58.15, -33.43 in-in in 8.596 Saltbr-in 2.741 HRD-in -83.69, -53.19 69.3, 12.83 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.44, 161.83 APE9-dihe-na 125.18, -160.92 APE8-dihe-in -119.48, 128.06 APE8-rot-in 308.71 APE67-dihe-in -61.97, -23.41 -42.69, -51.33 APE12-dist-in 8.108 APE11-dist-in 11.508 APE10-dist-in 6.0 APE9-dist-in 3.667 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 E 350 344 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EI P00517 4 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.284 14.622 BLAminus DFGAsp-rot-in -121.51, -176.84 52.35, 81.35 200.28, -6.62 -90.04, 28.89 273.59, 58.29 -59.59, -35.26 in-in in 8.515 Saltbr-in 2.667 HRD-in -96.55, -53.06 68.92, 16.49 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.85, 164.56 APE9-dihe-na 117.18, -165.89 APE8-dihe-in -113.08, 128.95 APE8-rot-in 295.01 APE67-dihe-in -62.64, -25.23 -41.3, -50.45 APE12-dist-in 8.183 APE11-dist-in 11.444 APE10-dist-in 5.901 APE9-dist-in 3.532 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 I 350 348 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EL P00517 14 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.356 14.445 BLAminus DFGAsp-rot-in -126.34, 179.53 56.51, 87.88 195.44, -5.61 -97.22, 26.99 274.78, 53.86 -54.08, -36.01 in-in in 8.49 Saltbr-in 2.906 HRD-in -84.79, -53.72 69.04, 14.43 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.8, 165.17 APE9-dihe-na 117.16, -168.03 APE8-dihe-in -109.85, 132.76 APE8-rot-in 309.54 APE67-dihe-in -58.05, -25.67 -43.08, -54.13 APE12-dist-in 8.074 APE11-dist-in 11.477 APE10-dist-in 5.89 APE9-dist-in 3.542 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 L 350 338 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 3E8EP P00517 8 351 351.0 G98:60351 Type1.5_Back Active DFGin 6.351 14.457 BLAminus DFGAsp-rot-in -129.89, 174.6 59.69, 84.32 192.63, 11.42 -91.75, 22.85 273.06, 63.33 -54.83, -37.28 in-in in 8.507 Saltbr-in 3.087 HRD-in -91.09, -52.59 71.75, 13.86 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.01, 169.23 APE9-dihe-na 113.75, -166.64 APE8-dihe-in -114.16, 128.38 APE8-rot-in 299.83 APE67-dihe-in -58.07, -28.95 -41.88, -52.2 APE12-dist-in 8.114 APE11-dist-in 11.425 APE10-dist-in 5.968 APE9-dist-in 3.544 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.0 0.245 0.279 P 350 344 0 0 0 0 [[44, 298]] 1.0 3e8e Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1XH9A P00517 14 351 351.0 R69:60351 Type1.5_Front Inactive DFGin 6.209 14.353 BLAminus DFGAsp-rot-out -129.75, -179.11 60.33, 73.87 284.38, -8.82 -88.04, 22.6 274.32, 67.63 -61.73, -24.72 in-in in 8.581 Saltbr-in 2.609 HRD-in -83.79, -50.21 70.28, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.47, 163.02 APE9-dihe-na 127.04, -169.55 APE8-dihe-in -104.83, 132.1 APE8-rot-in 300.02 APE67-dihe-in -61.76, -25.27 -43.65, -49.85 APE12-dist-in 8.298 APE11-dist-in 11.805 APE10-dist-in 6.219 APE9-dist-in 3.696 Q85E,V124A,L174M,Q182K,F188L TPO198,SEP339 TPO198,SEP339 XRAY 1.64 0.166 0.199 A 350 338 0 0 0 0 [[44, 298]] 1.0 1xh9 Bos taurus AGC_PRKACA_BOVIN AGC 1e-94 322.6 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1SVHA P00517 15 351 351.0 I08:60351 Type1.5_Front Inactive DFGin 6.29 14.359 BLAminus DFGAsp-rot-out -115.3, -171.03 56.71, 72.97 299.69, 70.16 -89.54, 18.36 276.49, 75.83 -65.64, -21.28 in-in in 8.519 Saltbr-in 2.417 HRD-in -84.39, -53.98 69.64, 16.78 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.15, 156.51 APE9-dihe-na 127.45, -173.0 APE8-dihe-in -94.86, 131.95 APE8-rot-in 296.28 APE67-dihe-in -64.98, -17.24 -40.94, -52.95 APE12-dist-in 8.685 APE11-dist-in 11.721 APE10-dist-in 6.22 APE9-dist-in 3.712 None TPO198,SEP339 TPO198,SEP339 XRAY 2.3 0.214 0.259 A 350 337 0 0 0 0 [[44, 298]] 1.0 1svh Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 4C35A P00517 11 351 351.0 NU3:61351 Type1.5_Back Inactive DFGin 5.96 15.117 None DFGAsp-rot-in -103.23, -88.31 -54.39, 108.88 206.23, -26.54 -97.56, 11.02 265.67, 64.27 -54.79, -37.29 in-in in 9.185 Saltbr-in 2.774 HRD-in -78.97, -53.39 72.53, 0.25 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.98, 158.62 APE9-dihe-na 121.3, -169.27 APE8-dihe-in -106.38, 130.41 APE8-rot-in 302.02 APE67-dihe-in -58.09, -26.56 -41.09, -54.15 APE12-dist-in 8.743 APE11-dist-in 11.613 APE10-dist-in 5.963 APE9-dist-in 3.427 F55Y,M121L,V124L,L174M,Q182K SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.19 0.186 0.24 A 351 341 0 0 0 0 [[44, 298]] 1.0 4c35 Bos taurus AGC_PRKACA_BOVIN AGC 8.1e-94 319.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7G P00517 13 351 351.0 ANP:403 ATPlike Inactive None 999.0 999.0 None DFGAsp-rot-none -155.4, -162.2 59.11, 63.62 999.0, 999.0 -70.57, 12.19 999.0, 999.0 -65.51, -34.83 out-none out 10.971 Saltbr-none 999.0 HRD-in -65.14, -55.26 50.7, 27.28 none-in-out SNCnio in-out ActLoopNT-in 2.575 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -166.96, 170.69 APE9-dihe-na 108.98, -156.8 APE8-dihe-in -102.79, 139.06 APE8-rot-none 999.0 APE67-dihe-in -58.63, -28.81 -67.98, -6.96 APE12-dist-in 9.228 APE11-dist-in 10.267 APE10-dist-in 6.438 APE9-dist-out 6.202 None None None EM 6.0 999.0 999.0 G 351 339 0 0 0 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW4K P00517 13 351 351.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -155.5, -168.49 59.79, 60.87 999.0, 999.0 -83.31, 16.99 999.0, 999.0 -58.46, -53.69 in-none in 9.884 Saltbr-none 999.0 HRD-in -75.2, -40.09 55.77, 26.65 none-in-none SNCnin in-none ActLoopNT-in 2.673 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -174.21, -178.74 APE9-dihe-na 106.6, -165.51 APE8-dihe-in -76.59, 132.39 APE8-rot-none 999.0 APE67-dihe-in -65.14, -23.53 -62.01, -33.48 APE12-dist-in 9.22 APE11-dist-in 11.751 APE10-dist-in 7.992 APE9-dist-in 5.26 None None None EM 9.0 999.0 999.0 K 351 331 0 0 0 0 [[44, 298]] 1.0 9dw4 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7K P00517 13 351 351.0 No_ligand No_ligand Inactive None 999.0 999.0 None DFGAsp-rot-none -155.25, -168.9 60.19, 60.97 999.0, 999.0 -83.26, 17.04 999.0, 999.0 -58.67, -53.39 in-none in 9.875 Saltbr-none 999.0 HRD-in -75.5, -40.23 55.96, 26.19 none-in-none SNCnin in-none ActLoopNT-in 2.684 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -174.15, -178.86 APE9-dihe-na 106.51, -165.36 APE8-dihe-in -77.09, 132.58 APE8-rot-none 999.0 APE67-dihe-in -65.64, -23.21 -62.33, -33.03 APE12-dist-in 9.222 APE11-dist-in 11.747 APE10-dist-in 7.971 APE9-dist-in 5.254 None None None EM 6.0 999.0 999.0 K 351 331 0 0 0 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC ROCK2 ROCK2_BOVIN 2F2UA Q28021 27 417 1388.0 M77:501 Type1 Inactive DFGin 6.154 13.964 ABAminus DFGAsp-rot-in -125.36, 20.74 -155.97, 132.58 197.63, -71.52 -140.63, 28.66 305.18, 93.77 -61.1, -20.63 in-in in 9.201 Saltbr-in 2.848 HRD-in -71.0, -56.95 70.45, 14.05 in-in-out SNCiio in-out ActLoopNT-in 3.1 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.24, 160.08 APE9-dihe-na 106.51, 163.99 APE8-dihe-in -75.45, 135.55 APE8-rot-out 188.78 APE67-dihe-in -58.72, -25.7 -36.99, -50.18 APE12-dist-in 9.876 APE11-dist-in 11.655 APE10-dist-in 5.753 APE9-dist-in 3.774 None None None XRAY 2.4 0.197 0.235 A 402 386 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_BOVIN 2H9VA Q28021 25 417 1388.0 Y27:500 Type1 Inactive DFGin 5.853 13.374 ABAminus DFGAsp-rot-in -112.95, -9.44 -122.76, 149.79 200.26, -62.74 -143.58, -5.13 306.08, 85.41 -38.72, -9.58 in-in in 9.203 Saltbr-in 2.722 HRD-in -79.43, -50.38 70.18, 0.12 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.4, 143.53 APE9-dihe-na 126.28, -170.44 APE8-dihe-in -95.31, 128.27 APE8-rot-in 291.56 APE67-dihe-in -48.07, -17.55 -32.2, -61.95 APE12-dist-in 10.14 APE11-dist-in 11.479 APE10-dist-in 5.82 APE9-dist-in 4.261 None None None XRAY 3.1 0.234 0.277 A 402 383 0 0 0 0 [[92, 354]] 1.0 2h9v Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_BOVIN 2F2UB Q28021 27 417 1388.0 M77:1501 Type1 Inactive DFGin 6.161 13.252 BLAminus DFGAsp-rot-out -137.47, 174.34 55.62, 88.13 307.6, -46.62 -108.95, 28.93 305.37, 102.14 -67.94, -16.5 in-in in 8.356 Saltbr-in 3.031 HRD-in -77.45, -48.84 68.99, 13.39 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -93.52, 138.42 APE9-dihe-na -106.28, -104.32 APE8-dihe-in -64.29, 128.15 APE8-rot-in 304.0 APE67-dihe-in -52.28, -37.75 -95.33, 10.69 APE12-dist-out 5.164 APE11-dist-in 9.625 APE10-dist-out 10.117 APE9-dist-out 9.097 None None None XRAY 2.4 0.197 0.235 B 402 383 0 0 0 0 [[92, 354]] 1.0 2f2u Bos taurus AGC_ROCK2_BOVIN AGC 2.6e-93 317.9 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC PKH2 PKH2_CANAL 4C0TA Q5A3P6 233 523 947.0 No_ligand No_ligand Inactive DFGin 6.59 14.145 BLAminus DFGAsp-rot-out -121.43, -167.15 54.49, 63.89 291.37, 27.41 -88.07, 25.71 293.46, 142.04 -75.8, -29.06 in-in in 9.305 Saltbr-in 3.099 HRD-in -59.87, -33.83 62.22, -58.21 in-in-out SNCiio in-out ActLoopNT-in 2.649 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -111.61, 122.52 APE9-dihe-na 150.05, -170.7 APE8-dihe-out -97.88, -21.8 APE8-rot-out 178.05 APE67-dihe-out -92.94, -29.37 59.84, 32.33 APE12-dist-in 11.298 APE11-dist-in 10.286 APE10-dist-out 10.93 APE9-dist-out 11.195 None SEP407 SEP407 XRAY 3.16 0.231 0.28 A 974 291 0 0 0 0 [[240, 502]] 1.0 4c0t Candida albicans AGC_PKH2_CANAL AGC 3.8e-67 232.5 1 260 260 381 382 383 385 387 269 288 292 361 363 362 364 430 418 413 412 411 410 409 408 407 319 Serine/threonine-protein kinase PKH2
AGC PRKACA KAPCA_CRIGR 5OUAA P25321 1 351 351.0 No_ligand No_ligand Inactive DFGin 6.718 14.635 ABAminus DFGAsp-rot-in -115.87, -28.94 -123.11, 121.25 191.61, -43.14 -116.35, 27.71 279.87, 77.2 -63.52, -23.18 in-in in 8.644 Saltbr-in 2.927 HRD-in -81.78, -54.82 73.94, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.08, 165.1 APE9-dihe-na 113.51, -165.37 APE8-dihe-in -110.07, 129.07 APE8-rot-in 298.26 APE67-dihe-in -59.52, -23.19 -44.71, -53.87 APE12-dist-in 8.325 APE11-dist-in 11.502 APE10-dist-in 5.764 APE9-dist-in 3.387 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.67 0.17 0.194 A 353 351 0 0 0 0 [[44, 298]] 1.0 5oua Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OUSA P25321 1 351 351.0 No_ligand No_ligand Inactive DFGin 6.507 15.429 ABAminus DFGAsp-rot-in -111.6, -55.85 -94.1, 116.86 196.8, -35.25 -107.2, 23.58 279.6, 77.36 -70.84, -13.23 in-none in 9.445 Saltbr-none 999.0 HRD-in -84.43, -53.59 72.65, 7.3 none-in-in SNCnii in-in ActLoopNT-in 3.002 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.86, 162.52 APE9-dihe-na 121.37, -167.35 APE8-dihe-in -115.92, 134.51 APE8-rot-in 300.98 APE67-dihe-in -58.34, -27.31 -46.95, -49.63 APE12-dist-in 8.255 APE11-dist-in 11.55 APE10-dist-in 5.951 APE9-dist-in 3.672 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.21 0.196 0.233 A 353 348 1 0 0 0 [[44, 298]] 1.0 5ous Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5NW8A P25321 12 351 351.0 M77:60402 Type1 Inactive DFGin 6.336 14.386 ABAminus DFGAsp-rot-out -118.68, -32.42 -99.03, 121.53 307.47, -24.99 -122.45, 23.74 290.12, 82.65 -65.48, -23.88 in-in in 8.884 Saltbr-in 2.705 HRD-in -87.46, -57.12 74.8, 8.43 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.41, 158.53 APE9-dihe-na 124.11, -167.34 APE8-dihe-in -113.09, 136.58 APE8-rot-in 301.73 APE67-dihe-in -53.51, -29.49 -47.53, -53.31 APE12-dist-in 8.204 APE11-dist-in 11.556 APE10-dist-in 5.922 APE9-dist-in 3.772 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.086 0.178 0.212 A 351 340 0 0 0 0 [[44, 298]] 1.0 5nw8 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.7e-95 323.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCPA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.513 14.567 ABAminus DFGAsp-rot-out -121.65, -30.45 -98.92, 119.1 306.4, -19.76 -122.07, 18.29 284.17, 84.65 -65.16, -27.53 in-in in 8.899 Saltbr-in 2.759 HRD-in -92.61, -56.98 71.24, 5.31 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.37, 152.55 APE9-dihe-na 132.49, -162.49 APE8-dihe-in -118.01, 135.22 APE8-rot-in 296.96 APE67-dihe-in -61.44, -24.53 -48.46, -49.38 APE12-dist-in 8.187 APE11-dist-in 11.476 APE10-dist-in 5.922 APE9-dist-in 3.949 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.433 0.134 0.166 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lcp Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCRA P25321 1 351 351.0 6TX:60401 Type1 Inactive DFGin 6.374 14.683 ABAminus DFGAsp-rot-out -120.45, -30.9 -97.04, 125.99 290.65, 9.34 -132.15, 14.59 283.38, 89.54 -63.35, -31.44 in-in in 8.849 Saltbr-in 2.672 HRD-in -87.18, -55.06 71.63, -3.59 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.81, 151.9 APE9-dihe-na 132.74, -162.98 APE8-dihe-in -119.91, 132.41 APE8-rot-in 297.04 APE67-dihe-in -57.71, -25.78 -46.99, -51.33 APE12-dist-in 8.235 APE11-dist-in 11.54 APE10-dist-in 6.002 APE9-dist-in 4.018 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.565 0.157 0.197 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lcr Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCTA P25321 1 351 351.0 6TY:60401 Type1 Inactive DFGin 6.567 14.972 ABAminus DFGAsp-rot-out -119.53, -36.47 -94.64, 123.81 285.08, 17.72 -127.4, 15.84 283.42, 88.07 -61.61, -36.92 in-in in 8.997 Saltbr-in 2.896 HRD-in -87.59, -53.98 70.09, 3.04 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.1, 153.93 APE9-dihe-na 129.99, -163.89 APE8-dihe-in -118.91, 134.19 APE8-rot-in 299.57 APE67-dihe-in -59.43, -24.77 -48.83, -49.96 APE12-dist-in 8.343 APE11-dist-in 11.612 APE10-dist-in 6.076 APE9-dist-in 3.98 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.615 0.144 0.174 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lct Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5LCUA P25321 1 351 351.0 IQP:60401 Type1 Inactive DFGin 6.344 14.512 ABAminus DFGAsp-rot-out -118.46, -33.64 -98.48, 122.71 295.04, 4.66 -128.59, 17.69 287.43, 87.65 -64.81, -32.5 in-in in 8.922 Saltbr-in 2.776 HRD-in -89.6, -56.25 69.6, 5.54 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.54, 154.63 APE9-dihe-na 129.64, -164.53 APE8-dihe-in -116.54, 134.11 APE8-rot-in 299.55 APE67-dihe-in -60.52, -23.05 -47.34, -51.22 APE12-dist-in 8.191 APE11-dist-in 11.541 APE10-dist-in 5.981 APE9-dist-in 3.971 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.579 0.154 0.192 A 353 351 0 0 0 0 [[44, 298]] 1.0 5lcu Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5M6VA P25321 1 351 351.0 H52:60401 Type1 Inactive DFGin 6.622 14.87 ABAminus DFGAsp-rot-out -128.93, -36.38 -82.47, 115.78 282.9, 33.29 -126.79, 13.38 284.62, 84.57 -59.9, -36.82 in-in in 9.146 Saltbr-in 3.067 HRD-in -85.39, -54.24 70.45, 5.3 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.08, 154.85 APE9-dihe-na 129.1, -162.88 APE8-dihe-in -117.77, 135.16 APE8-rot-in 297.05 APE67-dihe-in -61.78, -23.12 -47.87, -51.09 APE12-dist-in 8.256 APE11-dist-in 11.518 APE10-dist-in 5.981 APE9-dist-in 3.848 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.418 0.145 0.174 A 353 351 0 0 0 0 [[44, 298]] 1.0 5m6v Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5M6YA P25321 1 351 351.0 7KB:60401 Type1 Inactive DFGin 6.325 14.389 ABAminus DFGAsp-rot-out -120.54, -28.06 -100.7, 125.25 304.52, -16.18 -133.25, 5.41 291.12, 89.13 -59.31, -35.83 in-in in 8.957 Saltbr-in 2.869 HRD-in -85.55, -56.37 69.79, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.17, 152.58 APE9-dihe-na 128.14, -163.48 APE8-dihe-in -117.76, 135.16 APE8-rot-in 298.33 APE67-dihe-in -60.49, -24.28 -48.85, -50.14 APE12-dist-in 8.308 APE11-dist-in 11.715 APE10-dist-in 6.208 APE9-dist-in 4.06 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.367 0.145 0.166 A 353 351 0 0 0 0 [[44, 298]] 1.0 5m6y Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5M71A P25321 1 351 351.0 7K7:60401 Type1 Inactive DFGin 6.549 14.873 ABAminus DFGAsp-rot-out -119.85, -32.84 -98.53, 122.12 283.01, 22.92 -124.32, 17.46 284.12, 85.87 -64.55, -31.73 in-in in 9.056 Saltbr-in 2.764 HRD-in -87.14, -56.81 71.22, 6.23 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.13, 152.91 APE9-dihe-na 131.38, -162.26 APE8-dihe-in -116.74, 134.6 APE8-rot-in 297.69 APE67-dihe-in -60.19, -23.45 -48.52, -50.53 APE12-dist-in 8.226 APE11-dist-in 11.582 APE10-dist-in 5.99 APE9-dist-in 3.894 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.488 0.149 0.176 A 353 351 0 0 0 0 [[44, 298]] 1.0 5m71 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5M75A P25321 1 351 351.0 9K6:60402 Type1 Inactive DFGin 6.542 14.703 ABAminus DFGAsp-rot-out -122.93, -37.42 -95.22, 118.15 275.06, 41.93 -122.41, 18.78 283.61, 82.19 -61.66, -33.64 in-in in 9.017 Saltbr-in 2.902 HRD-in -86.66, -56.28 74.63, 2.67 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.02, 157.01 APE9-dihe-na 127.35, -165.16 APE8-dihe-in -116.36, 133.7 APE8-rot-in 297.39 APE67-dihe-in -60.71, -23.5 -48.32, -49.81 APE12-dist-in 8.225 APE11-dist-in 11.447 APE10-dist-in 5.924 APE9-dist-in 3.768 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.538 0.146 0.174 A 353 351 0 0 0 0 [[44, 298]] 1.0 5m75 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5N1DA P25321 1 351 351.0 8FZ:60403 Type1 Inactive DFGin 6.427 14.522 ABAminus DFGAsp-rot-out -119.36, -25.35 -95.05, 134.07 286.7, 81.0 -134.0, 35.23 286.49, 84.89 -74.09, -16.92 in-in in 8.967 Saltbr-in 2.774 HRD-in -86.75, -53.91 69.79, 6.83 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.28, 160.08 APE9-dihe-na 123.62, -165.42 APE8-dihe-in -115.29, 135.17 APE8-rot-in 295.44 APE67-dihe-in -60.76, -24.93 -47.42, -49.84 APE12-dist-in 8.38 APE11-dist-in 11.522 APE10-dist-in 5.945 APE9-dist-in 3.631 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.609 0.157 0.186 A 353 349 0 0 0 0 [[44, 298]] 1.0 5n1d Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5N3DA P25321 1 351 351.0 8NE:60401 Type1 Inactive DFGin 6.377 14.513 ABAminus DFGAsp-rot-in -125.06, 6.06 -141.01, 114.08 177.98, -23.17 -108.34, 25.78 270.84, 67.95 -65.47, -20.45 in-in in 8.802 Saltbr-in 2.893 HRD-in -88.66, -53.48 71.74, 8.74 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.56, 155.77 APE9-dihe-na 134.96, -165.87 APE8-dihe-in -106.38, 130.24 APE8-rot-in 300.79 APE67-dihe-in -61.42, -22.58 -44.45, -52.67 APE12-dist-in 8.462 APE11-dist-in 11.872 APE10-dist-in 6.295 APE9-dist-in 3.889 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.77 0.169 0.193 A 353 348 0 0 0 0 [[44, 298]] 1.0 5n3d Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5O0EA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.523 14.455 ABAminus DFGAsp-rot-out -120.87, -28.54 -98.9, 119.84 302.1, -14.33 -125.0, 19.69 283.23, 84.18 -67.0, -26.17 in-in in 8.861 Saltbr-in 2.786 HRD-in -91.49, -57.65 74.16, -1.91 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 154.58 APE9-dihe-na 133.99, -164.02 APE8-dihe-in -122.83, 136.35 APE8-rot-in 298.08 APE67-dihe-in -61.85, -22.28 -48.99, -49.98 APE12-dist-in 8.187 APE11-dist-in 11.413 APE10-dist-in 5.874 APE9-dist-in 4.06 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.5 0.133 0.17 A 353 351 0 0 0 0 [[44, 298]] 1.0 5o0e Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5O5MA P25321 10 351 351.0 9LQ:60401 Type1 Inactive DFGin 6.24 14.142 ABAminus DFGAsp-rot-out -103.5, -42.75 -109.64, 134.16 273.0, 55.93 -133.73, 10.26 296.02, 86.96 -61.7, -36.78 in-in in 8.847 Saltbr-in 2.793 HRD-in -81.57, -55.82 71.03, 6.22 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.12, 155.87 APE9-dihe-na 127.02, -162.8 APE8-dihe-in -117.37, 136.63 APE8-rot-in 301.79 APE67-dihe-in -60.33, -24.0 -47.69, -51.35 APE12-dist-in 8.418 APE11-dist-in 11.906 APE10-dist-in 6.388 APE9-dist-in 3.802 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.583 0.15 0.182 A 353 340 0 0 0 0 [[44, 298]] 1.0 5o5m Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OK3A P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.615 14.415 ABAminus DFGAsp-rot-out -120.44, -31.18 -98.89, 117.63 306.1, -19.76 -123.6, 23.39 284.71, 82.73 -69.59, -23.81 in-in in 8.934 Saltbr-in 2.739 HRD-in -95.2, -57.86 72.09, 2.44 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.84, 153.6 APE9-dihe-na 133.87, -163.65 APE8-dihe-in -122.15, 135.18 APE8-rot-in 299.79 APE67-dihe-in -60.82, -23.36 -49.17, -49.56 APE12-dist-in 8.219 APE11-dist-in 11.466 APE10-dist-in 5.878 APE9-dist-in 4.055 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.588 0.141 0.172 A 353 351 0 0 0 0 [[44, 298]] 1.0 5ok3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OL3A P25321 11 351 351.0 9LQ:60401 Type1 Inactive DFGin 6.293 14.139 ABAminus DFGAsp-rot-out -103.07, -42.44 -110.53, 139.16 275.3, 51.98 -139.44, 13.42 297.3, 87.11 -59.46, -35.81 in-in in 8.806 Saltbr-in 2.7 HRD-in -84.73, -54.59 70.4, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.98, 154.3 APE9-dihe-na 129.69, -160.74 APE8-dihe-in -119.81, 133.8 APE8-rot-in 301.31 APE67-dihe-in -59.48, -24.61 -48.47, -50.75 APE12-dist-in 8.523 APE11-dist-in 12.008 APE10-dist-in 6.495 APE9-dist-in 3.794 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.58 0.156 0.199 A 353 341 0 0 0 0 [[44, 298]] 1.0 5ol3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OT3A P25321 13 351 351.0 9LQ:60401 Type1 Inactive DFGin 6.384 14.236 ABAminus DFGAsp-rot-out -113.79, -34.42 -102.76, 127.41 280.13, 49.31 -133.44, 15.99 294.3, 89.2 -57.06, -43.48 in-in in 8.859 Saltbr-in 2.823 HRD-in -85.16, -56.21 73.39, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.31, 153.48 APE9-dihe-na 129.3, -161.89 APE8-dihe-in -114.87, 136.52 APE8-rot-in 300.43 APE67-dihe-in -56.81, -27.64 -51.93, -48.81 APE12-dist-in 8.291 APE11-dist-in 11.842 APE10-dist-in 6.305 APE9-dist-in 4.034 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.04 0.186 0.228 A 353 339 0 0 0 0 [[44, 298]] 1.0 5ot3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OTGA P25321 1 351 351.0 AO8:60401 Type1 Inactive DFGin 6.664 14.872 ABAminus DFGAsp-rot-out -116.07, -34.14 -101.63, 135.19 283.48, 8.33 -132.51, 30.55 284.27, 81.94 -65.58, -28.86 in-in in 9.208 Saltbr-in 2.884 HRD-in -87.0, -54.6 75.88, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.1, 159.53 APE9-dihe-na 126.93, -164.36 APE8-dihe-in -118.42, 136.98 APE8-rot-in 301.94 APE67-dihe-in -61.55, -22.37 -50.07, -49.22 APE12-dist-in 8.328 APE11-dist-in 11.566 APE10-dist-in 5.965 APE9-dist-in 3.74 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.73 0.187 0.206 A 353 351 0 0 0 0 [[44, 298]] 1.0 5otg Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5OUCA P25321 1 351 351.0 AO8:60401 Type1 Inactive DFGin 6.545 14.69 ABAminus DFGAsp-rot-out -118.72, -31.35 -98.66, 124.06 305.18, -23.27 -126.19, 22.18 285.25, 84.4 -64.9, -29.38 in-none in 9.015 Saltbr-none 999.0 HRD-in -89.21, -57.44 74.92, -2.84 none-in-in SNCnii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 152.91 APE9-dihe-na 134.96, -159.63 APE8-dihe-in -125.22, 135.43 APE8-rot-in 300.15 APE67-dihe-in -61.76, -25.06 -48.4, -50.36 APE12-dist-in 8.273 APE11-dist-in 11.481 APE10-dist-in 5.936 APE9-dist-in 4.015 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.46 0.151 0.175 A 353 351 0 0 0 0 [[44, 298]] 1.0 5ouc Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EGWA P25321 14 351 351.0 9LQ:60401 Type1 Inactive DFGin 6.068 14.052 ABAminus DFGAsp-rot-out -99.1, -40.07 -111.56, 135.78 274.73, 57.14 -136.64, 9.64 299.83, 90.65 -57.2, -34.91 in-in in 8.805 Saltbr-in 2.845 HRD-in -79.79, -53.68 65.28, 14.91 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.34, 128.68 APE9-dihe-na 131.12, -162.98 APE8-dihe-in -115.37, 129.12 APE8-rot-in 299.83 APE67-dihe-in -57.87, -22.06 -45.69, -53.12 APE12-dist-in 8.55 APE11-dist-in 12.035 APE10-dist-in 6.354 APE9-dist-in 3.77 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.74 0.173 0.203 A 353 336 1 0 0 0 [[44, 298]] 1.0 6egw Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EH3A P25321 1 351 351.0 B4Z:60401 Type1 Inactive DFGin 6.56 14.489 ABAminus DFGAsp-rot-out -116.24, -28.55 -105.91, 131.63 284.96, 13.08 -131.61, 27.16 287.22, 81.75 -60.81, -31.22 in-out in 9.006 Saltbr-out 3.768 HRD-in -84.94, -53.5 72.91, 0.92 out-in-in SNCoii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.18, 161.6 APE9-dihe-na 127.52, -167.93 APE8-dihe-in -115.28, 135.37 APE8-rot-in 300.84 APE67-dihe-in -65.2, -22.11 -46.47, -48.64 APE12-dist-in 8.279 APE11-dist-in 11.501 APE10-dist-in 5.911 APE9-dist-in 3.803 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.95 0.175 0.219 A 353 351 0 0 0 0 [[44, 298]] 1.0 6eh3 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERTA P25321 14 351 351.0 BVZ:60401 Type1 Inactive DFGin 6.194 14.121 ABAminus DFGAsp-rot-out -115.39, -20.57 -108.62, 132.15 278.15, 32.61 -135.58, 27.66 297.14, 82.68 -71.36, -3.39 in-in in 8.965 Saltbr-in 2.821 HRD-in -85.32, -55.78 74.89, 1.92 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.5, 160.76 APE9-dihe-na 124.06, -167.42 APE8-dihe-in -111.64, 135.9 APE8-rot-in 303.33 APE67-dihe-in -58.26, -26.08 -52.61, -48.73 APE12-dist-in 8.262 APE11-dist-in 11.627 APE10-dist-in 6.081 APE9-dist-in 3.755 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.8 0.186 0.218 A 353 338 0 0 0 0 [[44, 298]] 1.0 6ert Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERWA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.401 14.47 ABAminus DFGAsp-rot-out -121.15, -34.81 -95.55, 109.86 279.86, 38.68 -114.31, 21.73 291.27, 86.69 -64.06, -18.67 in-in in 8.902 Saltbr-in 2.874 HRD-in -86.55, -59.04 70.6, 12.67 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.31, 155.57 APE9-dihe-na 122.97, -167.43 APE8-dihe-in -109.73, 134.74 APE8-rot-in 295.31 APE67-dihe-in -57.25, -24.48 -52.2, -50.35 APE12-dist-in 8.161 APE11-dist-in 11.455 APE10-dist-in 5.864 APE9-dist-in 3.846 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.89 0.195 0.229 A 353 348 3 0 0 0 [[44, 298]] 1.0 6erw Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2AA P25321 1 351 351.0 M77:60401 Type1 Inactive DFGin 6.628 14.635 ABAminus DFGAsp-rot-out -122.01, -33.61 -93.89, 119.82 304.31, -17.17 -124.65, 22.24 282.35, 82.22 -67.92, -23.48 in-in in 9.193 Saltbr-in 2.561 HRD-in -101.03, -58.68 69.95, -0.61 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.26, 150.72 APE9-dihe-na 137.51, -163.36 APE8-dihe-in -120.26, 133.94 APE8-rot-in 301.03 APE67-dihe-in -62.45, -25.53 -48.16, -48.1 APE12-dist-in 8.121 APE11-dist-in 11.44 APE10-dist-in 5.894 APE9-dist-in 4.154 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.75 0.175 0.207 A 353 351 0 0 0 0 [[44, 298]] 1.0 6i2a Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2CA P25321 12 351 351.0 M77:60401 Type1 Inactive DFGin 6.5 14.606 ABAminus DFGAsp-rot-out -115.95, -34.45 -102.09, 116.9 301.65, -53.23 -120.62, 23.53 285.01, 87.65 -68.52, -23.98 in-in in 8.846 Saltbr-in 2.92 HRD-in -86.43, -55.89 76.54, -1.15 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.94, 153.26 APE9-dihe-na 129.65, -163.32 APE8-dihe-in -118.65, 136.78 APE8-rot-in 299.53 APE67-dihe-in -56.88, -28.13 -49.75, -50.61 APE12-dist-in 8.304 APE11-dist-in 11.519 APE10-dist-in 5.897 APE9-dist-in 3.716 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.82 0.187 0.221 A 353 338 2 0 0 0 [[44, 298]] 1.0 6i2c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2DA P25321 9 351 351.0 9LQ:60401 Type1 Inactive DFGin 6.486 14.691 ABAminus DFGAsp-rot-out -99.68, -45.99 -105.21, 136.79 272.83, 51.05 -132.46, 16.35 286.72, 86.8 -63.64, -34.15 in-in in 8.662 Saltbr-in 2.922 HRD-in -90.54, -57.71 68.94, 6.05 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.06, 154.58 APE9-dihe-na 132.32, -163.48 APE8-dihe-in -118.09, 133.54 APE8-rot-in 299.26 APE67-dihe-in -59.06, -24.95 -49.23, -49.12 APE12-dist-in 8.037 APE11-dist-in 11.595 APE10-dist-in 5.973 APE9-dist-in 3.959 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.91 0.19 0.222 A 353 343 0 0 0 0 [[44, 298]] 1.0 6i2d Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2HA P25321 1 351 351.0 AO8:60401 Type1 Inactive DFGin 6.567 14.809 ABAminus DFGAsp-rot-out -115.56, -38.67 -109.61, 104.13 275.65, 32.6 -103.25, 25.9 285.61, 77.71 -66.17, -17.47 in-in in 8.986 Saltbr-in 2.93 HRD-in -83.42, -55.73 70.56, 10.93 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.42, 160.46 APE9-dihe-na 121.97, -162.48 APE8-dihe-in -116.28, 135.78 APE8-rot-in 298.33 APE67-dihe-in -60.57, -22.98 -48.67, -52.6 APE12-dist-in 8.158 APE11-dist-in 11.371 APE10-dist-in 5.696 APE9-dist-in 3.548 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.68 0.182 0.202 A 353 351 0 0 0 0 [[44, 298]] 1.0 6i2h Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y0BA P25321 1 351 351.0 1LQ:60401 Type1 Inactive DFGin 6.361 14.329 ABAminus DFGAsp-rot-in -119.37, -25.73 -99.15, 124.17 197.46, -65.4 -126.15, 31.35 288.49, 83.65 -71.09, -16.36 in-in in 9.046 Saltbr-in 2.595 HRD-in -88.77, -52.67 71.85, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.54, 158.64 APE9-dihe-na 129.02, -163.22 APE8-dihe-in -120.14, 133.41 APE8-rot-in 298.13 APE67-dihe-in -64.32, -22.04 -50.27, -45.04 APE12-dist-in 8.22 APE11-dist-in 11.42 APE10-dist-in 5.896 APE9-dist-in 3.653 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.71 0.181 0.212 A 353 349 0 0 0 0 [[44, 298]] 1.0 6y0b Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y2UA P25321 1 351 351.0 LRT:60401 Type1 Inactive DFGin 6.39 14.127 ABAminus DFGAsp-rot-out -116.87, -29.74 -101.42, 118.51 289.7, 11.47 -125.0, 17.87 293.73, 84.27 -60.5, -32.85 in-in in 8.818 Saltbr-in 2.747 HRD-in -82.23, -56.84 69.37, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.67, 161.61 APE9-dihe-na 116.23, -161.47 APE8-dihe-in -111.19, 132.56 APE8-rot-in 301.77 APE67-dihe-in -58.37, -26.58 -47.25, -49.31 APE12-dist-in 8.18 APE11-dist-in 11.637 APE10-dist-in 5.977 APE9-dist-in 3.883 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.93 0.187 0.222 A 353 351 0 0 0 0 [[44, 298]] 1.0 6y2u Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7AXWA P25321 1 351 351.0 1SQ:60401 Type1 Inactive DFGin 6.404 14.253 ABAminus DFGAsp-rot-in -120.14, -30.0 -96.57, 126.41 198.95, -51.24 -127.77, 33.09 287.87, 84.79 -75.22, -10.69 in-in in 8.943 Saltbr-in 2.631 HRD-in -88.15, -50.93 71.59, -1.54 in-in-in SNCiii in-in ActLoopNT-in 2.841 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.41, 158.2 APE9-dihe-na 127.83, -163.7 APE8-dihe-in -120.34, 130.94 APE8-rot-in 298.02 APE67-dihe-in -65.73, -21.71 -43.41, -48.57 APE12-dist-in 8.201 APE11-dist-in 11.408 APE10-dist-in 5.931 APE9-dist-in 3.661 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 1.69 0.183 0.219 A 353 349 0 0 0 0 [[44, 298]] 1.0 7axw Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7BAQA P25321 12 351 351.0 T82:60401 Type1 Inactive DFGin 6.631 14.641 ABAminus DFGAsp-rot-out -123.23, -37.41 -116.05, 126.94 300.69, -74.37 -128.82, 27.15 284.58, 82.2 -65.24, -36.99 in-in in 8.875 Saltbr-in 2.826 HRD-in -84.32, -54.85 70.47, 4.72 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 160.75 APE9-dihe-na 122.68, -162.38 APE8-dihe-in -118.09, 132.31 APE8-rot-in 301.89 APE67-dihe-in -58.89, -25.14 -49.52, -49.11 APE12-dist-in 8.234 APE11-dist-in 11.524 APE10-dist-in 6.051 APE9-dist-in 3.737 None TPO198,SEP339 TPO198,SEP339 XRAY 1.54 0.178 0.22 A 353 340 0 0 0 0 [[44, 298]] 1.0 7baq Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7PIDA P25321 1 351 351.0 7QI:60401 Type1 Inactive DFGin 6.437 14.908 ABAminus DFGAsp-rot-out -118.24, -40.4 -94.33, 114.05 297.87, -21.58 -113.71, 22.91 282.95, 85.12 -67.72, -22.35 in-in in 9.146 Saltbr-in 3.197 HRD-in -88.95, -55.75 73.32, 6.65 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.62, 155.91 APE9-dihe-na 130.66, -167.59 APE8-dihe-in -113.9, 136.41 APE8-rot-in 298.55 APE67-dihe-in -61.41, -23.98 -47.99, -49.83 APE12-dist-in 8.261 APE11-dist-in 11.459 APE10-dist-in 5.868 APE9-dist-in 3.874 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.496 0.134 0.161 A 353 351 0 0 0 0 [[44, 298]] 1.0 7pid Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7PIEA P25321 1 351 351.0 7QF:60401 Type1 Inactive DFGin 6.437 14.708 ABAminus DFGAsp-rot-out -120.2, -32.0 -97.5, 116.46 300.4, -12.09 -117.79, 21.67 284.38, 87.37 -67.96, -24.99 in-in in 9.018 Saltbr-in 2.947 HRD-in -90.08, -55.75 70.92, 8.29 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 155.75 APE9-dihe-na 129.48, -166.45 APE8-dihe-in -116.19, 135.64 APE8-rot-in 298.32 APE67-dihe-in -59.08, -26.0 -47.12, -51.73 APE12-dist-in 8.298 APE11-dist-in 11.483 APE10-dist-in 5.921 APE9-dist-in 3.894 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.427 0.137 0.158 A 353 350 0 0 0 0 [[44, 298]] 1.0 7pie Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7PIFA P25321 1 351 351.0 7QL:60401 Type1 Inactive DFGin 6.346 14.218 ABAminus DFGAsp-rot-out -118.69, -29.14 -100.96, 122.87 296.89, -5.87 -127.55, 15.73 291.19, 87.86 -63.07, -33.16 in-in in 8.957 Saltbr-in 2.787 HRD-in -92.08, -57.05 70.77, -0.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 150.21 APE9-dihe-na 133.66, -162.89 APE8-dihe-in -122.64, 134.78 APE8-rot-in 297.75 APE67-dihe-in -60.89, -24.83 -47.76, -50.71 APE12-dist-in 8.301 APE11-dist-in 11.573 APE10-dist-in 6.001 APE9-dist-in 4.135 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.395 0.135 0.155 A 353 351 0 0 0 0 [[44, 298]] 1.0 7pif Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7PIGA P25321 1 351 351.0 7QR:60401 Type1 Inactive DFGin 6.481 14.876 ABAminus DFGAsp-rot-out -122.28, -26.17 -100.91, 119.71 298.05, -10.12 -123.06, 20.32 285.86, 92.34 -68.86, -24.06 in-in in 8.922 Saltbr-in 2.747 HRD-in -91.36, -59.49 70.09, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.9, 150.63 APE9-dihe-na 129.65, -165.04 APE8-dihe-in -112.18, 133.86 APE8-rot-in 299.17 APE67-dihe-in -59.53, -25.5 -47.67, -52.22 APE12-dist-in 8.155 APE11-dist-in 11.441 APE10-dist-in 5.843 APE9-dist-in 4.068 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.553 0.129 0.154 A 353 351 0 0 0 0 [[44, 298]] 1.0 7pig Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 7PNSA P25321 10 351 351.0 7W8:60402 Type1 Inactive DFGin 6.514 14.817 ABAminus DFGAsp-rot-in -119.8, -32.67 -110.21, 109.27 191.33, -30.39 -108.01, 28.37 286.1, 78.14 -68.46, -20.09 in-in in 8.98 Saltbr-in 3.084 HRD-in -83.54, -55.5 71.62, 9.07 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.45, 157.3 APE9-dihe-na 125.01, -165.6 APE8-dihe-in -110.51, 134.07 APE8-rot-in 302.08 APE67-dihe-in -61.89, -24.52 -46.65, -50.8 APE12-dist-in 8.324 APE11-dist-in 11.619 APE10-dist-in 6.032 APE9-dist-in 3.821 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.855 0.176 0.202 A 353 342 0 0 0 0 [[44, 298]] 1.0 7pns Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6I2BA P25321 5 351 351.0 9LQ:60401,9LQ:60402 Type1,Allosteric Inactive DFGin 6.308 14.501 ABAminus DFGAsp-rot-out -99.36, -48.22 -103.96, 139.83 276.71, 48.67 -136.93, 15.62 290.92, 85.14 -58.8, -40.25 in-in in 8.684 Saltbr-in 2.806 HRD-in -93.94, -54.86 69.46, 4.74 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.47, 156.84 APE9-dihe-na 128.63, -164.41 APE8-dihe-in -116.79, 133.75 APE8-rot-in 301.48 APE67-dihe-in -59.49, -25.74 -49.19, -49.96 APE12-dist-in 8.136 APE11-dist-in 11.621 APE10-dist-in 6.009 APE9-dist-in 3.953 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.97 0.212 0.248 A 353 345 0 0 0 0 [[44, 298]] 1.0 6i2b Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 9REKA P25321 12 351 351.0 D8P:60401,D8P:60402,D8P:60403,D8P:60404 Type1,Allosteric,Allosteric,Allosteric Inactive DFGin 6.343 14.439 ABAminus DFGAsp-rot-in -107.25, -41.44 -100.58, 143.12 193.83, 85.55 -128.51, 27.13 273.04, 65.71 -61.45, -23.67 in-in in 8.578 Saltbr-in 2.778 HRD-in -87.09, -53.39 71.15, 12.36 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.7, 168.09 APE9-dihe-na 116.77, -166.86 APE8-dihe-in -118.41, 135.56 APE8-rot-in 302.89 APE67-dihe-in -59.2, -22.22 -49.04, -50.02 APE12-dist-in 8.172 APE11-dist-in 11.118 APE10-dist-in 5.634 APE9-dist-in 3.737 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.38 0.159 0.19 A 353 339 1 0 0 0 [[44, 298]] 1.0 9rek Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR