AlphaFold2 models of the active form of human typical protein kinase domains

A complete set of new active models (February 2026) of all 437 catalytic human protein kinases constructed with AlphaFold2

Download the zip file here.

Kincore_standalone2 (2023): Python3 code for calculating the conformational state of typical protein kinases. Calculates all the parameters for determining whether a kinase is active. Will be updated for 2026 criteria shortly.

Link to github here.

FASTA files of sequences used to model 437 human catalytic typical protein kinase domains with AlphaFold2

Download the tar.gz file here.

FASTA files of orthologs and close paralogs for all 437 human catalytic typical protein kinase domains

Download the tar.gz file here.

2023 Preprint: AlphaFold2 models of the active form of all 437 catalytically-competent typical human kinase domains. 2026 preprint available shortly.

Download the 2023 preprint here.

Slides from ISMB-3DSIG talk (July 25, 2023): Combining structural bioinformatics and deep-learning-based protein structure prediction: AlphaFold2 models of all 437 catalytically competent human kinases in the active form

Download the slides here.