PDB: 8C3G — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8C3GA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 8C3GA Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.743 15.056 BLAminus -122.4, 159.11 70.62, 87.46 -99.56, 24.8 280.34, 73.41 -66.95, -22.86 in-in in 8.66 Saltbr-in 2.906 HRD-in -63.26, -48.03 79.68, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 166.89 APE9-dihe-na 73.47, 141.67 APE8-dihe-in -65.32, 142.21 APE8-rot-in 286.57 APE67-dihe-in -55.53, -29.43 -49.01, -52.14 APE12-dist-in 13.368 APE11-dist-in 11.339 APE10-dist-in 7.622 APE9-dist-in 3.122 None PTR321 PTR321 XRAY 2.08 0.196 0.237 A 371 344 3 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GB Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.619 14.965 BLAminus -126.26, 160.88 70.82, 88.0 -100.32, 24.36 284.04, 76.33 -69.92, -22.03 in-in in 8.69 Saltbr-in 2.709 HRD-in -65.16, -43.7 77.31, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 171.66 APE9-dihe-na 68.35, 154.78 APE8-dihe-in -74.32, 140.03 APE8-rot-in 274.86 APE67-dihe-in -57.14, -31.61 -51.55, -47.48 APE12-dist-in 13.897 APE11-dist-in 11.795 APE10-dist-in 7.918 APE9-dist-in 3.068 None PTR321 PTR321 XRAY 2.08 0.196 0.237 B 371 333 14 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GC Q13627 134 480 763.0 QS0:502 Type1 Active DFGin 7.39 14.702 BLAminus -128.69, 158.7 71.6, 91.39 -100.86, 21.74 282.48, 82.23 -71.28, -20.67 in-in in 8.486 Saltbr-in 2.828 HRD-in -70.94, -40.51 73.81, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 166.28 APE9-dihe-na 71.87, 146.61 APE8-dihe-in -66.83, 145.54 APE8-rot-in 302.42 APE67-dihe-in -61.67, -26.79 -57.09, -43.66 APE12-dist-in 13.613 APE11-dist-in 11.865 APE10-dist-in 7.836 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.08 0.196 0.237 C 371 341 6 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GD Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.385 14.915 BLAminus -133.23, 162.85 62.78, 88.13 -95.33, 26.44 290.5, 77.86 -68.41, -23.5 in-in in 8.607 Saltbr-in 2.822 HRD-in -60.07, -49.82 78.57, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 174.1 APE9-dihe-na 67.56, 148.97 APE8-dihe-in -66.35, 140.59 APE8-rot-in 265.57 APE67-dihe-in -54.42, -30.15 -57.29, -47.59 APE12-dist-in 13.746 APE11-dist-in 12.049 APE10-dist-in 7.901 APE9-dist-in 3.058 None PTR321 PTR321 XRAY 2.08 0.196 0.237 D 371 337 10 0 0 0 [[159, 479]] 1.0 8c3g CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 8C3G — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8C3GA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 8C3GA Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.743 15.056 BLAminus -122.4, 159.11 70.62, 87.46 -99.56, 24.8 280.34, 73.41 -66.95, -22.86 in-in in 8.66 Saltbr-in 2.906 HRD-in -63.26, -48.03 79.68, -2.67 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.78, 166.89 APE9-dihe-na 73.47, 141.67 APE8-dihe-in -65.32, 142.21 APE8-rot-in 286.57 APE67-dihe-in -55.53, -29.43 -49.01, -52.14 APE12-dist-in 13.368 APE11-dist-in 11.339 APE10-dist-in 7.622 APE9-dist-in 3.122 None PTR321 PTR321 XRAY 2.08 0.196 0.237 A 371 344 3 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GB Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.619 14.965 BLAminus -126.26, 160.88 70.82, 88.0 -100.32, 24.36 284.04, 76.33 -69.92, -22.03 in-in in 8.69 Saltbr-in 2.709 HRD-in -65.16, -43.7 77.31, -6.37 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 171.66 APE9-dihe-na 68.35, 154.78 APE8-dihe-in -74.32, 140.03 APE8-rot-in 274.86 APE67-dihe-in -57.14, -31.61 -51.55, -47.48 APE12-dist-in 13.897 APE11-dist-in 11.795 APE10-dist-in 7.918 APE9-dist-in 3.068 None PTR321 PTR321 XRAY 2.08 0.196 0.237 B 371 333 14 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GC Q13627 134 480 763.0 QS0:502 Type1 Active DFGin 7.39 14.702 BLAminus -128.69, 158.7 71.6, 91.39 -100.86, 21.74 282.48, 82.23 -71.28, -20.67 in-in in 8.486 Saltbr-in 2.828 HRD-in -70.94, -40.51 73.81, -8.22 in-in-in SNCiii in-in ActLoopNT-in 2.715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.57, 166.28 APE9-dihe-na 71.87, 146.61 APE8-dihe-in -66.83, 145.54 APE8-rot-in 302.42 APE67-dihe-in -61.67, -26.79 -57.09, -43.66 APE12-dist-in 13.613 APE11-dist-in 11.865 APE10-dist-in 7.836 APE9-dist-in 3.181 None PTR321 PTR321 XRAY 2.08 0.196 0.237 C 371 341 6 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8C3GD Q13627 134 480 763.0 QS0:501 Type1 Active DFGin 7.385 14.915 BLAminus -133.23, 162.85 62.78, 88.13 -95.33, 26.44 290.5, 77.86 -68.41, -23.5 in-in in 8.607 Saltbr-in 2.822 HRD-in -60.07, -49.82 78.57, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.4, 174.1 APE9-dihe-na 67.56, 148.97 APE8-dihe-in -66.35, 140.59 APE8-rot-in 265.57 APE67-dihe-in -54.42, -30.15 -57.29, -47.59 APE12-dist-in 13.746 APE11-dist-in 12.049 APE10-dist-in 7.901 APE9-dist-in 3.058 None PTR321 PTR321 XRAY 2.08 0.196 0.237 D 371 337 10 0 0 0 [[159, 479]] 1.0 8c3g Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.3e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 8C3G — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name