PDB: 7ZH8 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7ZH8A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7ZH8A Q13627 135 482 763.0 IWU:501,IWU:503 Type1,Allosteric Active DFGin 6.93 14.485 BLAminus -122.84, 179.43 62.46, 67.96 -84.46, 26.09 290.83, 71.55 -67.12, -11.2 in-in in 8.883 Saltbr-in 2.724 HRD-in -63.87, -44.79 74.86, -8.37 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.43, 165.77 APE9-dihe-na 78.45, 153.82 APE8-dihe-in -75.88, 144.9 APE8-rot-in 282.17 APE67-dihe-in -60.66, -29.31 -54.53, -47.47 APE12-dist-in 12.842 APE11-dist-in 11.113 APE10-dist-in 7.113 APE9-dist-in 3.047 None PTR321 PTR321 XRAY 2.3 0.199 0.235 A 382 348 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8B Q13627 135 481 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 7.016 14.696 BLAminus -126.24, 176.32 61.01, 72.92 -85.71, 26.03 289.71, 74.68 -65.98, -19.69 in-in in 8.922 Saltbr-in 2.551 HRD-in -62.74, -46.92 79.26, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.66, 167.11 APE9-dihe-na 77.27, 157.6 APE8-dihe-in -78.84, 143.58 APE8-rot-in 289.38 APE67-dihe-in -64.23, -22.19 -57.38, -41.71 APE12-dist-in 12.706 APE11-dist-in 11.378 APE10-dist-in 7.012 APE9-dist-in 3.066 None PTR321 PTR321 XRAY 2.3 0.199 0.235 B 382 347 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8C Q13627 136 481 763.0 IWU:502,IWU:504 Type1,Allosteric Active DFGin 6.95 14.526 BLAminus -134.74, -179.56 61.5, 68.92 -87.34, 24.99 287.1, 79.14 -63.98, -23.48 in-in in 8.908 Saltbr-in 2.284 HRD-in -62.72, -47.25 75.43, -4.98 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.64, 173.03 APE9-dihe-na 68.29, 149.69 APE8-dihe-in -67.12, 144.66 APE8-rot-in 287.21 APE67-dihe-in -61.1, -29.22 -57.48, -42.67 APE12-dist-in 12.923 APE11-dist-in 11.192 APE10-dist-in 6.996 APE9-dist-in 3.16 None PTR321 PTR321 XRAY 2.3 0.199 0.235 C 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8D Q13627 135 480 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 6.962 14.615 BLAminus -123.17, -177.61 59.0, 69.45 -88.29, 28.99 287.8, 74.48 -73.6, -11.3 in-in in 8.821 Saltbr-in 2.61 HRD-in -61.94, -44.56 72.7, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 172.59 APE9-dihe-na 67.75, 147.93 APE8-dihe-in -73.89, 139.89 APE8-rot-in 260.52 APE67-dihe-in -46.52, -33.56 -54.25, -52.57 APE12-dist-in 12.275 APE11-dist-in 11.283 APE10-dist-in 6.938 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.3 0.199 0.235 D 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 7ZH8 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7ZH8A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 7ZH8A Q13627 135 482 763.0 IWU:501,IWU:503 Type1,Allosteric Active DFGin 6.93 14.485 BLAminus -122.84, 179.43 62.46, 67.96 -84.46, 26.09 290.83, 71.55 -67.12, -11.2 in-in in 8.883 Saltbr-in 2.724 HRD-in -63.87, -44.79 74.86, -8.37 in-in-in SNCiii in-in ActLoopNT-in 2.763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.43, 165.77 APE9-dihe-na 78.45, 153.82 APE8-dihe-in -75.88, 144.9 APE8-rot-in 282.17 APE67-dihe-in -60.66, -29.31 -54.53, -47.47 APE12-dist-in 12.842 APE11-dist-in 11.113 APE10-dist-in 7.113 APE9-dist-in 3.047 None PTR321 PTR321 XRAY 2.3 0.199 0.235 A 382 348 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8B Q13627 135 481 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 7.016 14.696 BLAminus -126.24, 176.32 61.01, 72.92 -85.71, 26.03 289.71, 74.68 -65.98, -19.69 in-in in 8.922 Saltbr-in 2.551 HRD-in -62.74, -46.92 79.26, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.66, 167.11 APE9-dihe-na 77.27, 157.6 APE8-dihe-in -78.84, 143.58 APE8-rot-in 289.38 APE67-dihe-in -64.23, -22.19 -57.38, -41.71 APE12-dist-in 12.706 APE11-dist-in 11.378 APE10-dist-in 7.012 APE9-dist-in 3.066 None PTR321 PTR321 XRAY 2.3 0.199 0.235 B 382 347 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8C Q13627 136 481 763.0 IWU:502,IWU:504 Type1,Allosteric Active DFGin 6.95 14.526 BLAminus -134.74, -179.56 61.5, 68.92 -87.34, 24.99 287.1, 79.14 -63.98, -23.48 in-in in 8.908 Saltbr-in 2.284 HRD-in -62.72, -47.25 75.43, -4.98 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.64, 173.03 APE9-dihe-na 68.29, 149.69 APE8-dihe-in -67.12, 144.66 APE8-rot-in 287.21 APE67-dihe-in -61.1, -29.22 -57.48, -42.67 APE12-dist-in 12.923 APE11-dist-in 11.192 APE10-dist-in 6.996 APE9-dist-in 3.16 None PTR321 PTR321 XRAY 2.3 0.199 0.235 C 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7ZH8D Q13627 135 480 763.0 IWU:501,IWU:502 Type1,Allosteric Active DFGin 6.962 14.615 BLAminus -123.17, -177.61 59.0, 69.45 -88.29, 28.99 287.8, 74.48 -73.6, -11.3 in-in in 8.821 Saltbr-in 2.61 HRD-in -61.94, -44.56 72.7, -0.97 in-in-in SNCiii in-in ActLoopNT-in 2.549 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.11, 172.59 APE9-dihe-na 67.75, 147.93 APE8-dihe-in -73.89, 139.89 APE8-rot-in 260.52 APE67-dihe-in -46.52, -33.56 -54.25, -52.57 APE12-dist-in 12.275 APE11-dist-in 11.283 APE10-dist-in 6.938 APE9-dist-in 3.153 None PTR321 PTR321 XRAY 2.3 0.199 0.235 D 382 346 0 0 0 0 [[159, 479]] 1.0 7zh8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 7ZH8 — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name