PDB: 6YF8 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6YF8A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6YF8A Q13627 134 480 763.0 OPW:501 Type1 Active DFGin 7.367 15.037 BLAminus -107.79, 169.33 69.2, 81.79 -99.28, 28.66 285.18, 77.14 -72.43, -31.23 in-in in 8.601 Saltbr-in 2.847 HRD-in -65.51, -44.05 74.67, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 162.23 APE9-dihe-na 71.89, 151.15 APE8-dihe-in -78.29, 144.29 APE8-rot-in 300.07 APE67-dihe-in -58.27, -31.82 -55.32, -42.67 APE12-dist-in 13.883 APE11-dist-in 11.463 APE10-dist-in 7.639 APE9-dist-in 3.269 None PTR321 PTR321 XRAY 3.198 0.251 0.283 A 368 342 5 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8B Q13627 133 480 763.0 OPW:501 Type1 Active DFGin 7.35 14.819 BLAminus -117.64, 170.81 65.81, 81.87 -100.82, 27.57 293.99, 81.4 -77.25, -30.97 in-in in 8.702 Saltbr-in 2.634 HRD-in -63.24, -42.07 74.0, 14.09 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.69, 162.87 APE9-dihe-na 65.58, 155.56 APE8-dihe-in -69.5, 152.58 APE8-rot-in 294.46 APE67-dihe-in -60.85, -36.35 -65.13, -40.78 APE12-dist-in 13.566 APE11-dist-in 11.269 APE10-dist-in 7.757 APE9-dist-in 3.284 None PTR321 PTR321 XRAY 3.198 0.251 0.283 B 368 340 8 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8C Q13627 135 479 763.0 OPW:501 Type1 Inactive DFGin 7.06 14.935 BLAminus -124.46, 168.16 66.21, 86.05 -102.5, 27.56 285.91, 74.18 -71.62, -35.88 in-in in 8.498 Saltbr-in 2.557 HRD-in -64.26, -45.7 70.47, 20.75 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.66, 167.21 APE9-dihe-na 69.24, 168.75 APE8-dihe-in -80.92, 148.18 APE8-rot-out 33.92 APE67-dihe-in -67.11, -24.9 -61.32, -43.38 APE12-dist-in 13.864 APE11-dist-in 11.499 APE10-dist-in 7.931 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 3.198 0.251 0.283 C 368 333 12 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8D Q13627 134 479 763.0 OPW:501 Type1 Active DFGin 7.163 14.672 BLAminus -129.06, 157.06 74.04, 87.38 -102.12, 32.5 287.46, 75.26 -75.18, -28.37 in-in in 8.607 Saltbr-in 3.368 HRD-in -62.03, -42.61 74.97, 8.8 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.1, 162.77 APE9-dihe-na 71.6, 148.13 APE8-dihe-in -72.02, 126.06 APE8-rot-in 276.95 APE67-dihe-in -35.21, -29.98 -36.67, -74.72 APE12-dist-in 13.536 APE11-dist-in 11.438 APE10-dist-in 7.66 APE9-dist-in 3.254 None PTR321 PTR321 XRAY 3.198 0.251 0.283 D 368 331 15 0 0 0 [[159, 479]] 1.0 6yf8 CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6YF8 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6YF8A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6YF8A Q13627 134 480 763.0 OPW:501 Type1 Active DFGin 7.367 15.037 BLAminus -107.79, 169.33 69.2, 81.79 -99.28, 28.66 285.18, 77.14 -72.43, -31.23 in-in in 8.601 Saltbr-in 2.847 HRD-in -65.51, -44.05 74.67, 9.56 in-in-in SNCiii in-in ActLoopNT-in 2.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.05, 162.23 APE9-dihe-na 71.89, 151.15 APE8-dihe-in -78.29, 144.29 APE8-rot-in 300.07 APE67-dihe-in -58.27, -31.82 -55.32, -42.67 APE12-dist-in 13.883 APE11-dist-in 11.463 APE10-dist-in 7.639 APE9-dist-in 3.269 None PTR321 PTR321 XRAY 3.198 0.251 0.283 A 368 342 5 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8B Q13627 133 480 763.0 OPW:501 Type1 Active DFGin 7.35 14.819 BLAminus -117.64, 170.81 65.81, 81.87 -100.82, 27.57 293.99, 81.4 -77.25, -30.97 in-in in 8.702 Saltbr-in 2.634 HRD-in -63.24, -42.07 74.0, 14.09 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.69, 162.87 APE9-dihe-na 65.58, 155.56 APE8-dihe-in -69.5, 152.58 APE8-rot-in 294.46 APE67-dihe-in -60.85, -36.35 -65.13, -40.78 APE12-dist-in 13.566 APE11-dist-in 11.269 APE10-dist-in 7.757 APE9-dist-in 3.284 None PTR321 PTR321 XRAY 3.198 0.251 0.283 B 368 340 8 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8C Q13627 135 479 763.0 OPW:501 Type1 Inactive DFGin 7.06 14.935 BLAminus -124.46, 168.16 66.21, 86.05 -102.5, 27.56 285.91, 74.18 -71.62, -35.88 in-in in 8.498 Saltbr-in 2.557 HRD-in -64.26, -45.7 70.47, 20.75 in-in-out SNCiio in-out ActLoopNT-in 2.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.66, 167.21 APE9-dihe-na 69.24, 168.75 APE8-dihe-in -80.92, 148.18 APE8-rot-out 33.92 APE67-dihe-in -67.11, -24.9 -61.32, -43.38 APE12-dist-in 13.864 APE11-dist-in 11.499 APE10-dist-in 7.931 APE9-dist-in 3.227 None PTR321 PTR321 XRAY 3.198 0.251 0.283 C 368 333 12 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6YF8D Q13627 134 479 763.0 OPW:501 Type1 Active DFGin 7.163 14.672 BLAminus -129.06, 157.06 74.04, 87.38 -102.12, 32.5 287.46, 75.26 -75.18, -28.37 in-in in 8.607 Saltbr-in 3.368 HRD-in -62.03, -42.61 74.97, 8.8 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.1, 162.77 APE9-dihe-na 71.6, 148.13 APE8-dihe-in -72.02, 126.06 APE8-rot-in 276.95 APE67-dihe-in -35.21, -29.98 -36.67, -74.72 APE12-dist-in 13.536 APE11-dist-in 11.438 APE10-dist-in 7.66 APE9-dist-in 3.254 None PTR321 PTR321 XRAY 3.198 0.251 0.283 D 368 331 15 0 0 0 [[159, 479]] 1.0 6yf8 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6YF8 — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name