| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVA | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.4293 | 14.257 | BLAminus | -133.87, 178.6 | 61.51, 90.4 | -109.85, 28.17 | 289.99, 77.52 | -67.6, -31.52 | in-in | in | 8.3241 | Saltbr-in | 2.9312 | HRD-in | -62.66, -43.13 | 71.32, -8.68 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7324 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 119.68 | APE8-rot-na | 14.07 | APE67-dihe-in | -79.55, -1.3 | -80.03, -13.82 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | A | 285.0 | 266.0 | 18 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVB | P52333 | 815 | 1099 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.1943 | 14.2143 | BLAminus | -135.38, 176.48 | 64.47, 86.88 | -105.43, 20.89 | 286.69, 85.17 | -66.35, -29.51 | in-in | in | 8.1494 | Saltbr-in | 2.8265 | HRD-in | -61.18, -44.44 | 71.7, 4.93 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.6907 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 129.11 | APE8-rot-na | 330.57 | APE67-dihe-in | -79.98, -2.63 | -77.74, -18.2 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | B | 285.0 | 269.0 | 16 | 31 | 25 | 6 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVC | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.477 | 14.2719 | BLAminus | -130.86, 179.06 | 58.44, 90.28 | -109.09, 23.07 | 290.05, 84.12 | -62.59, -33.96 | in-in | in | 8.0905 | Saltbr-in | 2.8088 | HRD-in | -69.82, -48.24 | 78.15, -8.29 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.6892 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -41.25 | APE8-dihe-in | -66.72, 131.5 | APE8-rot-na | 341.69 | APE67-dihe-in | -75.5, -7.29 | -73.63, -18.87 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 6.346 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | C | 285.0 | 265.0 | 19 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVD | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.418 | 14.1518 | BLAminus | -133.07, -178.12 | 58.66, 85.08 | -104.02, 25.84 | 292.67, 81.24 | -61.98, -32.78 | in-in | in | 8.1402 | Saltbr-in | 2.7701 | HRD-in | -71.74, -43.92 | 75.22, -14.51 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7079 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -35.5 | APE8-dihe-in | -66.27, 131.93 | APE8-rot-na | 340.52 | APE67-dihe-in | -79.97, 1.1 | -77.2, -17.1 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 6.6337 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | D | 285.0 | 259.0 | 25 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVA | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.4293 | 14.257 | BLAminus | -133.87, 178.6 | 61.51, 90.4 | -109.85, 28.17 | 289.99, 77.52 | -67.6, -31.52 | in-in | in | 8.3241 | Saltbr-in | 2.9312 | HRD-in | -62.66, -43.13 | 71.32, -8.68 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7324 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 119.68 | APE8-rot-na | 14.07 | APE67-dihe-in | -79.55, -1.3 | -80.03, -13.82 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | A | 285.0 | 266.0 | 18 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVB | P52333 | 815 | 1099 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.1943 | 14.2143 | BLAminus | -135.38, 176.48 | 64.47, 86.88 | -105.43, 20.89 | 286.69, 85.17 | -66.35, -29.51 | in-in | in | 8.1494 | Saltbr-in | 2.8265 | HRD-in | -61.18, -44.44 | 71.7, 4.93 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.6907 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 129.11 | APE8-rot-na | 330.57 | APE67-dihe-in | -79.98, -2.63 | -77.74, -18.2 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | B | 285.0 | 269.0 | 16 | 31 | 25 | 6 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVC | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.477 | 14.2719 | BLAminus | -130.86, 179.06 | 58.44, 90.28 | -109.09, 23.07 | 290.05, 84.12 | -62.59, -33.96 | in-in | in | 8.0905 | Saltbr-in | 2.8088 | HRD-in | -69.82, -48.24 | 78.15, -8.29 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.6892 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -41.25 | APE8-dihe-in | -66.72, 131.5 | APE8-rot-na | 341.69 | APE67-dihe-in | -75.5, -7.29 | -73.63, -18.87 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 6.346 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | C | 285.0 | 265.0 | 19 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6HZVD | P52333 | 815 | 1098 | 1124.0 | GYW:1101 | Type1 | None | DFGin | 6.418 | 14.1518 | BLAminus | -133.07, -178.12 | 58.66, 85.08 | -104.02, 25.84 | 292.67, 81.24 | -61.98, -32.78 | in-in | in | 8.1402 | Saltbr-in | 2.7701 | HRD-in | -71.74, -43.92 | 75.22, -14.51 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.7079 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, -35.5 | APE8-dihe-in | -66.27, 131.93 | APE8-rot-na | 340.52 | APE67-dihe-in | -79.97, 1.1 | -77.2, -17.1 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 6.6337 | None | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.46 | 0.224 | 0.275 | D | 285.0 | 259.0 | 25 | 31 | 26 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6hzv | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1.0 | 260.0 | 260.0 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949.0 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|