PDB: 6EIJ — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIJA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIJA Q13627 134 480 763.0 B5Z:501 Type1 Inactive DFGin 7.364 15.562 BLAminus -121.9, 173.42 62.65, 84.26 -101.23, 24.54 287.56, 69.73 -71.05, -32.94 in-out in 9.316 Saltbr-out 4.407 HRD-in -64.87, -43.16 72.94, 6.35 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 163.75 APE9-dihe-na 69.36, 155.02 APE8-dihe-in -79.85, 135.64 APE8-rot-in 297.55 APE67-dihe-in -62.23, -27.92 -43.08, -47.75 APE12-dist-in 13.698 APE11-dist-in 11.612 APE10-dist-in 7.695 APE9-dist-in 3.216 None PTR321 PTR321 XRAY 2.42 0.215 0.242 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJB Q13627 133 480 763.0 B5Z:501 Type1 Active DFGin 7.267 15.528 BLAminus -117.59, 170.7 64.63, 89.36 -107.31, 30.62 285.29, 75.01 -79.8, -27.42 in-in in 9.004 Saltbr-in 3.483 HRD-in -63.56, -41.89 71.27, 6.78 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 156.57 APE9-dihe-na 71.57, 144.46 APE8-dihe-in -65.65, 143.73 APE8-rot-in 301.69 APE67-dihe-in -60.34, -27.61 -53.56, -46.19 APE12-dist-in 13.554 APE11-dist-in 11.232 APE10-dist-in 7.686 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.42 0.215 0.242 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJD Q13627 134 479 763.0 B5Z:501 Type1 Active DFGin 7.495 15.445 BLAminus -110.58, 169.11 63.21, 88.34 -100.92, 29.04 284.12, 76.0 -75.59, -27.16 in-in in 9.051 Saltbr-in 2.765 HRD-in -55.24, -46.68 74.47, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 166.58 APE9-dihe-na 66.27, 155.62 APE8-dihe-in -75.66, 150.91 APE8-rot-in 302.31 APE67-dihe-in -58.65, -28.49 -61.4, -47.04 APE12-dist-in 13.802 APE11-dist-in 11.742 APE10-dist-in 7.729 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.42 0.215 0.242 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJC Q13627 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus -119.52, 178.29 74.66, 62.43 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6EIJ — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6EIJA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6EIJA Q13627 134 480 763.0 B5Z:501 Type1 Inactive DFGin 7.364 15.562 BLAminus -121.9, 173.42 62.65, 84.26 -101.23, 24.54 287.56, 69.73 -71.05, -32.94 in-out in 9.316 Saltbr-out 4.407 HRD-in -64.87, -43.16 72.94, 6.35 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.18, 163.75 APE9-dihe-na 69.36, 155.02 APE8-dihe-in -79.85, 135.64 APE8-rot-in 297.55 APE67-dihe-in -62.23, -27.92 -43.08, -47.75 APE12-dist-in 13.698 APE11-dist-in 11.612 APE10-dist-in 7.695 APE9-dist-in 3.216 None PTR321 PTR321 XRAY 2.42 0.215 0.242 A 368 342 5 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJB Q13627 133 480 763.0 B5Z:501 Type1 Active DFGin 7.267 15.528 BLAminus -117.59, 170.7 64.63, 89.36 -107.31, 30.62 285.29, 75.01 -79.8, -27.42 in-in in 9.004 Saltbr-in 3.483 HRD-in -63.56, -41.89 71.27, 6.78 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.2, 156.57 APE9-dihe-na 71.57, 144.46 APE8-dihe-in -65.65, 143.73 APE8-rot-in 301.69 APE67-dihe-in -60.34, -27.61 -53.56, -46.19 APE12-dist-in 13.554 APE11-dist-in 11.232 APE10-dist-in 7.686 APE9-dist-in 3.196 None PTR321 PTR321 XRAY 2.42 0.215 0.242 B 368 340 8 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJD Q13627 134 479 763.0 B5Z:501 Type1 Active DFGin 7.495 15.445 BLAminus -110.58, 169.11 63.21, 88.34 -100.92, 29.04 284.12, 76.0 -75.59, -27.16 in-in in 9.051 Saltbr-in 2.765 HRD-in -55.24, -46.68 74.47, 11.33 in-in-in SNCiii in-in ActLoopNT-in 2.95 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.83, 166.58 APE9-dihe-na 66.27, 155.62 APE8-dihe-in -75.66, 150.91 APE8-rot-in 302.31 APE67-dihe-in -58.65, -28.49 -61.4, -47.04 APE12-dist-in 13.802 APE11-dist-in 11.742 APE10-dist-in 7.729 APE9-dist-in 3.253 None PTR321 PTR321 XRAY 2.42 0.215 0.242 D 368 339 7 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6EIJC Q13627 135 479 763.0 B5Z:501 Type1.5_Front Inactive DFGin 7.322 15.822 BLAminus -119.52, 178.29 74.66, 62.43 -90.76, 17.19 281.65, 84.11 -79.88, -15.93 in-in in 8.813 Saltbr-in 2.837 HRD-in -61.62, -44.31 72.29, 10.77 in-in-out SNCiio in-out ActLoopNT-in 3.127 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -131.72, 163.63 APE9-dihe-na 69.62, 151.36 APE8-dihe-in -71.38, 142.46 APE8-rot-in 288.31 APE67-dihe-in -55.52, -31.51 -56.59, -47.99 APE12-dist-in 13.973 APE11-dist-in 12.181 APE10-dist-out 8.281 APE9-dist-in 3.331 None PTR321 PTR321 XRAY 2.42 0.215 0.242 C 368 338 7 0 0 0 [[159, 479]] 1.0 6eij Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6EIJ — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name