| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CMGC | DYRK3 | DYRK3_HUMAN | 5Y86A | O43781 | 138 | 532 | 588.0 | HRM:601 | Type1 | Active | DFGin | 6.8785 | 14.4347 | BLAminus | -121.42, 179.23 | 66.2, 57.54 | -80.8, 21.54 | 289.69, 73.67 | -71.73, -12.45 | in-in | in | 8.7751 | Saltbr-in | 2.7965 | HRD-in | -69.17, -46.88 | 74.51, 0.82 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.947 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -133.75, 169.09 | APE9-dihe-na | 75.29, 154.26 | APE8-dihe-in | -74.45, 137.02 | APE8-rot-in | 292.62 | APE67-dihe-in | -59.3, -23.84 | -52.98, -46.9 | APE12-dist-in | 12.6939 | APE11-dist-in | 11.5005 | APE10-dist-in | 7.0456 | APE9-dist-in | 3.0767 | None | SEP350,PTR369,SEP445,TPO512 | SEP350,PTR369,SEP445,TPO512 | XRAY | 1.9 | 0.168 | 0.196 | A | 588.0 | 395.0 | 0 | 25 | 25 | 0 | [[209, 522]] | 1.0 | 5y86 | CMGC_DYRK3_HUMAN | CMGC | 1.8e-97 | 332.3 | 1.0 | 301.0 | 301.0 | 354 | 355 | 356 | 358 | 360 | 238 | 253 | 257 | 332 | 334 | 333 | 335.0 | 391 | 379 | 374 | 373 | 372 | 371 | 370 | 369 | 368 | 289 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CMGC | DYRK3 | DYRK3_HUMAN | 5Y86A | O43781 | 138 | 532 | 588.0 | HRM:601 | Type1 | Active | DFGin | 6.8785 | 14.4347 | BLAminus | -121.42, 179.23 | 66.2, 57.54 | -80.8, 21.54 | 289.69, 73.67 | -71.73, -12.45 | in-in | in | 8.7751 | Saltbr-in | 2.7965 | HRD-in | -69.17, -46.88 | 74.51, 0.82 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.947 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -133.75, 169.09 | APE9-dihe-na | 75.29, 154.26 | APE8-dihe-in | -74.45, 137.02 | APE8-rot-in | 292.62 | APE67-dihe-in | -59.3, -23.84 | -52.98, -46.9 | APE12-dist-in | 12.6939 | APE11-dist-in | 11.5005 | APE10-dist-in | 7.0456 | APE9-dist-in | 3.0767 | None | SEP350,PTR369,SEP445,TPO512 | SEP350,PTR369,SEP445,TPO512 | XRAY | 1.9 | 0.168 | 0.196 | A | 588.0 | 395.0 | 0 | 25 | 25 | 0 | [[209, 522]] | 1.0 | 5y86 | Homo sapiens | CMGC_DYRK3_HUMAN | CMGC | 1.8e-97 | 332.3 | 1.0 | 301.0 | 301.0 | 354 | 355 | 356 | 358 | 360 | 238 | 253 | 257 | 332 | 334 | 333 | 335.0 | 391 | 379 | 374 | 373 | 372 | 371 | 370 | 369 | 368 | 289 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|