| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVA | P78362 | 68 | 688 | 688.0 | W4A:60716 | Type1 | Active | DFGin | 6.3313 | 13.7968 | BLAminus | -133.46, -174.64 | 58.65, 65.32 | -91.15, 13.08 | 272.47, 67.35 | -64.26, -23.28 | in-in | in | 9.3566 | Saltbr-in | 3.0829 | HRD-in | -70.14, -43.35 | 74.24, -2.44 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8643 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.85, 167.12 | APE9-dihe-na | 72.17, 138.55 | APE8-dihe-in | -70.17, 145.46 | APE8-rot-in | 301.36 | APE67-dihe-in | -69.9, -15.95 | -41.31, -56.88 | APE12-dist-in | 12.6187 | APE11-dist-in | 10.6133 | APE10-dist-in | 7.8698 | APE9-dist-in | 3.275 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | A | 389.0 | 352.0 | 18 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVB | P78362 | 68 | 688 | 688.0 | W4A:60715 | Type1 | Active | DFGin | 6.3521 | 13.6549 | BLAminus | -132.14, -175.28 | 57.36, 67.15 | -90.74, 14.57 | 272.3, 66.38 | -64.24, -22.8 | in-in | in | 9.2412 | Saltbr-in | 3.0948 | HRD-in | -69.52, -44.04 | 73.41, -1.98 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.864 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -118.88, 167.32 | APE9-dihe-na | 72.34, 139.4 | APE8-dihe-in | -70.2, 145.35 | APE8-rot-in | 302.58 | APE67-dihe-in | -69.24, -15.62 | -41.36, -56.93 | APE12-dist-in | 12.6187 | APE11-dist-in | 10.5716 | APE10-dist-in | 7.7454 | APE9-dist-in | 3.2628 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | B | 389.0 | 349.0 | 21 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVC | P78362 | 68 | 688 | 688.0 | W4A:60711 | Type1 | Active | DFGin | 6.3593 | 13.6388 | BLAminus | -132.33, -176.42 | 57.94, 66.74 | -90.66, 15.47 | 272.12, 68.19 | -64.19, -23.57 | in-in | in | 9.1965 | Saltbr-in | 3.0916 | HRD-in | -69.62, -44.12 | 73.53, -2.08 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.863 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.53, 167.9 | APE9-dihe-na | 72.74, 138.77 | APE8-dihe-in | -70.13, 144.97 | APE8-rot-in | 302.67 | APE67-dihe-in | -69.14, -16.02 | -41.1, -56.52 | APE12-dist-in | 12.5876 | APE11-dist-in | 10.5578 | APE10-dist-in | 7.697 | APE9-dist-in | 3.2608 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | C | 389.0 | 348.0 | 22 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVD | P78362 | 68 | 688 | 688.0 | W4A:60710 | Type1 | Active | DFGin | 6.2235 | 14.174 | BLAminus | -133.23, -174.98 | 56.82, 67.21 | -92.06, 16.8 | 272.08, 71.69 | -66.01, -21.98 | in-in | in | 9.4443 | Saltbr-in | 3.099 | HRD-in | -69.59, -43.92 | 73.56, -1.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8694 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.31, 167.24 | APE9-dihe-na | 72.07, 138.65 | APE8-dihe-in | -70.56, 145.29 | APE8-rot-in | 303.66 | APE67-dihe-in | -69.61, -15.98 | -41.64, -56.92 | APE12-dist-in | 12.6188 | APE11-dist-in | 10.3916 | APE10-dist-in | 7.7163 | APE9-dist-in | 3.2673 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | D | 389.0 | 351.0 | 19 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVA | P78362 | 68 | 688 | 688.0 | W4A:60716 | Type1 | Active | DFGin | 6.3313 | 13.7968 | BLAminus | -133.46, -174.64 | 58.65, 65.32 | -91.15, 13.08 | 272.47, 67.35 | -64.26, -23.28 | in-in | in | 9.3566 | Saltbr-in | 3.0829 | HRD-in | -70.14, -43.35 | 74.24, -2.44 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8643 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.85, 167.12 | APE9-dihe-na | 72.17, 138.55 | APE8-dihe-in | -70.17, 145.46 | APE8-rot-in | 301.36 | APE67-dihe-in | -69.9, -15.95 | -41.31, -56.88 | APE12-dist-in | 12.6187 | APE11-dist-in | 10.6133 | APE10-dist-in | 7.8698 | APE9-dist-in | 3.275 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | A | 389.0 | 352.0 | 18 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | Homo sapiens | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVB | P78362 | 68 | 688 | 688.0 | W4A:60715 | Type1 | Active | DFGin | 6.3521 | 13.6549 | BLAminus | -132.14, -175.28 | 57.36, 67.15 | -90.74, 14.57 | 272.3, 66.38 | -64.24, -22.8 | in-in | in | 9.2412 | Saltbr-in | 3.0948 | HRD-in | -69.52, -44.04 | 73.41, -1.98 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.864 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -118.88, 167.32 | APE9-dihe-na | 72.34, 139.4 | APE8-dihe-in | -70.2, 145.35 | APE8-rot-in | 302.58 | APE67-dihe-in | -69.24, -15.62 | -41.36, -56.93 | APE12-dist-in | 12.6187 | APE11-dist-in | 10.5716 | APE10-dist-in | 7.7454 | APE9-dist-in | 3.2628 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | B | 389.0 | 349.0 | 21 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | Homo sapiens | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVC | P78362 | 68 | 688 | 688.0 | W4A:60711 | Type1 | Active | DFGin | 6.3593 | 13.6388 | BLAminus | -132.33, -176.42 | 57.94, 66.74 | -90.66, 15.47 | 272.12, 68.19 | -64.19, -23.57 | in-in | in | 9.1965 | Saltbr-in | 3.0916 | HRD-in | -69.62, -44.12 | 73.53, -2.08 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.863 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -119.53, 167.9 | APE9-dihe-na | 72.74, 138.77 | APE8-dihe-in | -70.13, 144.97 | APE8-rot-in | 302.67 | APE67-dihe-in | -69.14, -16.02 | -41.1, -56.52 | APE12-dist-in | 12.5876 | APE11-dist-in | 10.5578 | APE10-dist-in | 7.697 | APE9-dist-in | 3.2608 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | C | 389.0 | 348.0 | 22 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | Homo sapiens | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| CMGC | SRPK2 | SRPK2_HUMAN | 5MYVD | P78362 | 68 | 688 | 688.0 | W4A:60710 | Type1 | Active | DFGin | 6.2235 | 14.174 | BLAminus | -133.23, -174.98 | 56.82, 67.21 | -92.06, 16.8 | 272.08, 71.69 | -66.01, -21.98 | in-in | in | 9.4443 | Saltbr-in | 3.099 | HRD-in | -69.59, -43.92 | 73.56, -1.28 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.8694 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -121.31, 167.24 | APE9-dihe-na | 72.07, 138.65 | APE8-dihe-in | -70.56, 145.29 | APE8-rot-in | 303.66 | APE67-dihe-in | -69.61, -15.98 | -41.64, -56.92 | APE12-dist-in | 12.6188 | APE11-dist-in | 10.3916 | APE10-dist-in | 7.7163 | APE9-dist-in | 3.2673 | None | None | None | XRAY | 2.9 | 0.2 | 0.217 | D | 389.0 | 351.0 | 19 | 25 | 25 | 0 | [[81, 686]] | 1.0 | 5myv | Homo sapiens | CMGC_SRPK2_HUMAN | CMGC | 1.4e-144 | 486.7 | 1.0 | 301.0 | 301.0 | 529 | 530 | 531 | 533 | 535 | 110 | 125 | 129 | 211 | 213 | 212 | 214.0 | 566 | 554 | 549 | 548 | 547 | 546 | 545 | 544 | 543 | 167 | SRSF protein kinase 2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|