PDB: 5A4Q — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4QA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4QA Q13627 134 480 763.0 Y3L:1482 Type1 Inactive DFGin 7.38 14.947 BLAminus -121.96, 169.12 70.4, 82.32 -101.36, 21.61 281.14, 85.06 -74.47, -27.67 in-in in 8.557 Saltbr-in 2.795 HRD-in -68.17, -45.62 80.68, 0.25 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.46, 166.81 APE9-dihe-na 68.32, 157.62 APE8-dihe-in -82.19, 145.27 APE8-rot-in 292.08 APE67-dihe-in -61.8, -22.63 -55.55, -46.76 APE12-dist-in 13.736 APE11-dist-in 11.739 APE10-dist-out 8.013 APE9-dist-in 3.183 None PTR321 PTR321 XRAY 2.37 0.208 0.243 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QB Q13627 133 480 763.0 Y3L:1482 Type1 Active DFGin 7.332 15.167 BLAminus -119.07, 169.96 69.93, 79.11 -95.25, 24.02 288.84, 81.96 -59.31, -40.09 in-in in 8.8 Saltbr-in 2.743 HRD-in -65.5, -47.61 81.19, 5.21 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.35, 160.28 APE9-dihe-na 76.8, 155.69 APE8-dihe-in -77.08, 143.17 APE8-rot-in 298.14 APE67-dihe-in -56.03, -30.73 -51.27, -50.53 APE12-dist-in 13.619 APE11-dist-in 11.706 APE10-dist-in 7.959 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.37 0.208 0.243 B 368 336 12 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QC Q13627 135 479 763.0 Y3L:1481 Type1 Inactive DFGin 7.364 15.042 BLAminus -123.78, 162.78 68.52, 86.63 -104.38, 24.62 284.41, 77.47 -79.32, -18.49 in-in in 8.564 Saltbr-in 2.739 HRD-in -62.28, -44.19 78.26, -0.42 in-in-out SNCiio in-out ActLoopNT-in 3.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -129.11, 155.72 APE9-dihe-na 82.33, 164.45 APE8-dihe-in -86.88, 143.97 APE8-rot-out 35.24 APE67-dihe-in -42.95, -31.53 -51.33, -61.96 APE12-dist-in 13.912 APE11-dist-in 11.966 APE10-dist-out 8.185 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.37 0.208 0.243 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QD Q13627 134 479 763.0 Y3L:1481 Type1 Active DFGin 7.54 14.858 BLAminus -122.22, 174.03 62.3, 86.45 -97.65, 23.49 289.45, 76.37 -75.31, -20.37 in-in in 8.511 Saltbr-in 2.499 HRD-in -56.95, -45.96 79.67, 1.76 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 163.2 APE9-dihe-na 73.87, 148.99 APE8-dihe-in -76.47, 142.42 APE8-rot-in 301.45 APE67-dihe-in -56.86, -27.34 -54.99, -48.13 APE12-dist-in 13.838 APE11-dist-in 11.826 APE10-dist-in 7.868 APE9-dist-in 3.329 None PTR321 PTR321 XRAY 2.37 0.208 0.243 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4q CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 5A4Q — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4QA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4QA Q13627 134 480 763.0 Y3L:1482 Type1 Inactive DFGin 7.38 14.947 BLAminus -121.96, 169.12 70.4, 82.32 -101.36, 21.61 281.14, 85.06 -74.47, -27.67 in-in in 8.557 Saltbr-in 2.795 HRD-in -68.17, -45.62 80.68, 0.25 in-in-out SNCiio in-out ActLoopNT-in 3.014 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -134.46, 166.81 APE9-dihe-na 68.32, 157.62 APE8-dihe-in -82.19, 145.27 APE8-rot-in 292.08 APE67-dihe-in -61.8, -22.63 -55.55, -46.76 APE12-dist-in 13.736 APE11-dist-in 11.739 APE10-dist-out 8.013 APE9-dist-in 3.183 None PTR321 PTR321 XRAY 2.37 0.208 0.243 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QB Q13627 133 480 763.0 Y3L:1482 Type1 Active DFGin 7.332 15.167 BLAminus -119.07, 169.96 69.93, 79.11 -95.25, 24.02 288.84, 81.96 -59.31, -40.09 in-in in 8.8 Saltbr-in 2.743 HRD-in -65.5, -47.61 81.19, 5.21 in-in-in SNCiii in-in ActLoopNT-in 3.026 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.35, 160.28 APE9-dihe-na 76.8, 155.69 APE8-dihe-in -77.08, 143.17 APE8-rot-in 298.14 APE67-dihe-in -56.03, -30.73 -51.27, -50.53 APE12-dist-in 13.619 APE11-dist-in 11.706 APE10-dist-in 7.959 APE9-dist-in 3.304 None PTR321 PTR321 XRAY 2.37 0.208 0.243 B 368 336 12 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QC Q13627 135 479 763.0 Y3L:1481 Type1 Inactive DFGin 7.364 15.042 BLAminus -123.78, 162.78 68.52, 86.63 -104.38, 24.62 284.41, 77.47 -79.32, -18.49 in-in in 8.564 Saltbr-in 2.739 HRD-in -62.28, -44.19 78.26, -0.42 in-in-out SNCiio in-out ActLoopNT-in 3.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -129.11, 155.72 APE9-dihe-na 82.33, 164.45 APE8-dihe-in -86.88, 143.97 APE8-rot-out 35.24 APE67-dihe-in -42.95, -31.53 -51.33, -61.96 APE12-dist-in 13.912 APE11-dist-in 11.966 APE10-dist-out 8.185 APE9-dist-in 3.243 None PTR321 PTR321 XRAY 2.37 0.208 0.243 C 368 333 12 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4QD Q13627 134 479 763.0 Y3L:1481 Type1 Active DFGin 7.54 14.858 BLAminus -122.22, 174.03 62.3, 86.45 -97.65, 23.49 289.45, 76.37 -75.31, -20.37 in-in in 8.511 Saltbr-in 2.499 HRD-in -56.95, -45.96 79.67, 1.76 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.06, 163.2 APE9-dihe-na 73.87, 148.99 APE8-dihe-in -76.47, 142.42 APE8-rot-in 301.45 APE67-dihe-in -56.86, -27.34 -54.99, -48.13 APE12-dist-in 13.838 APE11-dist-in 11.826 APE10-dist-in 7.868 APE9-dist-in 3.329 None PTR321 PTR321 XRAY 2.37 0.208 0.243 D 368 335 11 0 0 0 [[159, 479]] 1.0 5a4q Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 5A4Q — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name