PDB: 5A4E — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4EA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4EA Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.22 14.874 BLAminus -126.54, 177.15 58.69, 94.29 -113.21, 22.28 286.19, 77.0 -59.45, -31.21 in-in in 8.568 Saltbr-in 2.779 HRD-in -64.66, -42.27 66.83, 14.81 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.09, 163.61 APE9-dihe-na 69.48, 158.79 APE8-dihe-in -72.55, 147.75 APE8-rot-in 295.07 APE67-dihe-in -58.22, -29.01 -58.76, -47.93 APE12-dist-in 13.575 APE11-dist-in 11.747 APE10-dist-in 7.974 APE9-dist-in 3.174 None PTR321 PTR321 XRAY 2.68 0.237 0.268 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4EB Q13627 133 480 763.0 7QQ:1482 Type1 Active DFGin 7.399 14.881 BLAminus -121.24, 173.6 64.11, 83.73 -104.73, 23.57 287.63, 75.52 -70.09, -36.48 in-in in 8.688 Saltbr-in 2.932 HRD-in -51.94, -37.2 69.96, 8.72 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.62, 169.1 APE9-dihe-na 63.21, 149.19 APE8-dihe-in -68.01, 145.26 APE8-rot-in 293.25 APE67-dihe-in -62.27, -28.2 -53.9, -51.02 APE12-dist-in 13.549 APE11-dist-in 11.424 APE10-dist-in 7.915 APE9-dist-in 3.305 None PTR321 PTR321 XRAY 2.68 0.237 0.268 B 368 323 25 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4EC Q13627 134 473 763.0 7QQ:1475 Type1 Inactive DFGin 7.237 14.787 BLAminus -138.1, 157.66 68.63, 87.31 -107.74, 30.93 287.87, 90.33 -77.47, -44.69 in-out in 8.675 Saltbr-out 4.117 HRD-in -57.3, -42.31 66.35, 18.38 out-in-out SNCoio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.87, 162.91 APE9-dihe-na 69.03, 158.68 APE8-dihe-in -76.06, 149.31 APE8-rot-in 284.97 APE67-dihe-in -59.95, -35.01 -52.77, -51.14 APE12-dist-in 13.793 APE11-dist-in 11.825 APE10-dist-out 8.193 APE9-dist-in 3.39 None PTR321 PTR321 XRAY 2.68 0.237 0.268 C 368 263 83 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4ED Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.084 14.377 BLAminus -127.03, 161.26 72.91, 98.11 -113.73, 26.73 293.48, 83.38 -71.75, -27.39 in-in in 8.717 Saltbr-in 2.757 HRD-in -62.4, -41.11 73.31, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.98, 167.15 APE9-dihe-na 68.52, 159.57 APE8-dihe-in -79.96, 125.33 APE8-rot-in 300.98 APE67-dihe-in -48.76, -38.1 -29.58, -60.85 APE12-dist-in 13.723 APE11-dist-in 11.606 APE10-dist-in 7.713 APE9-dist-in 3.246 None PTR321 PTR321 XRAY 2.68 0.237 0.268 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a4e CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 5A4E — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5A4EA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 5A4EA Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.22 14.874 BLAminus -126.54, 177.15 58.69, 94.29 -113.21, 22.28 286.19, 77.0 -59.45, -31.21 in-in in 8.568 Saltbr-in 2.779 HRD-in -64.66, -42.27 66.83, 14.81 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.09, 163.61 APE9-dihe-na 69.48, 158.79 APE8-dihe-in -72.55, 147.75 APE8-rot-in 295.07 APE67-dihe-in -58.22, -29.01 -58.76, -47.93 APE12-dist-in 13.575 APE11-dist-in 11.747 APE10-dist-in 7.974 APE9-dist-in 3.174 None PTR321 PTR321 XRAY 2.68 0.237 0.268 A 368 342 5 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4EB Q13627 133 480 763.0 7QQ:1482 Type1 Active DFGin 7.399 14.881 BLAminus -121.24, 173.6 64.11, 83.73 -104.73, 23.57 287.63, 75.52 -70.09, -36.48 in-in in 8.688 Saltbr-in 2.932 HRD-in -51.94, -37.2 69.96, 8.72 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.62, 169.1 APE9-dihe-na 63.21, 149.19 APE8-dihe-in -68.01, 145.26 APE8-rot-in 293.25 APE67-dihe-in -62.27, -28.2 -53.9, -51.02 APE12-dist-in 13.549 APE11-dist-in 11.424 APE10-dist-in 7.915 APE9-dist-in 3.305 None PTR321 PTR321 XRAY 2.68 0.237 0.268 B 368 323 25 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4EC Q13627 134 473 763.0 7QQ:1475 Type1 Inactive DFGin 7.237 14.787 BLAminus -138.1, 157.66 68.63, 87.31 -107.74, 30.93 287.87, 90.33 -77.47, -44.69 in-out in 8.675 Saltbr-out 4.117 HRD-in -57.3, -42.31 66.35, 18.38 out-in-out SNCoio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -106.87, 162.91 APE9-dihe-na 69.03, 158.68 APE8-dihe-in -76.06, 149.31 APE8-rot-in 284.97 APE67-dihe-in -59.95, -35.01 -52.77, -51.14 APE12-dist-in 13.793 APE11-dist-in 11.825 APE10-dist-out 8.193 APE9-dist-in 3.39 None PTR321 PTR321 XRAY 2.68 0.237 0.268 C 368 263 83 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 5A4ED Q13627 134 480 763.0 7QQ:1482 Type1 Active DFGin 7.084 14.377 BLAminus -127.03, 161.26 72.91, 98.11 -113.73, 26.73 293.48, 83.38 -71.75, -27.39 in-in in 8.717 Saltbr-in 2.757 HRD-in -62.4, -41.11 73.31, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.98, 167.15 APE9-dihe-na 68.52, 159.57 APE8-dihe-in -79.96, 125.33 APE8-rot-in 300.98 APE67-dihe-in -48.76, -38.1 -29.58, -60.85 APE12-dist-in 13.723 APE11-dist-in 11.606 APE10-dist-in 7.713 APE9-dist-in 3.246 None PTR321 PTR321 XRAY 2.68 0.237 0.268 D 368 332 15 0 0 0 [[159, 479]] 1.0 5a4e Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 5A4E — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name