PDB: 4YU2 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YU2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4YU2A Q13627 134 482 763.0 4H5:502 Type1 Active DFGin 7.126 14.681 BLAminus -128.42, 169.74 66.24, 87.83 -106.58, 30.41 288.45, 76.74 -70.77, -21.27 in-in in 8.585 Saltbr-in 2.926 HRD-in -65.53, -46.44 78.54, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.92, 172.99 APE9-dihe-na 68.27, 148.59 APE8-dihe-in -64.99, 149.49 APE8-rot-in 273.44 APE67-dihe-in -60.93, -28.26 -62.53, -43.49 APE12-dist-in 12.736 APE11-dist-in 11.533 APE10-dist-in 7.136 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 A 361 349 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2B Q13627 134 481 763.0 4H5:502 Type1 Active DFGin 7.151 14.752 BLAminus -128.64, 169.94 65.22, 90.88 -106.36, 30.6 290.28, 73.66 -70.15, -21.89 in-in in 8.572 Saltbr-in 2.91 HRD-in -64.42, -46.95 79.44, 4.22 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 173.47 APE9-dihe-na 67.52, 148.21 APE8-dihe-in -62.89, 148.04 APE8-rot-in 274.18 APE67-dihe-in -57.33, -29.6 -62.96, -44.24 APE12-dist-in 12.881 APE11-dist-in 11.9 APE10-dist-in 7.282 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.9 0.245 0.277 B 361 348 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2C Q13627 135 481 763.0 4H5:502 Type1 Active DFGin 7.149 14.733 BLAminus -129.97, 170.39 64.97, 89.04 -105.39, 29.51 288.7, 75.12 -70.27, -20.52 in-in in 8.571 Saltbr-in 2.901 HRD-in -64.55, -48.15 80.68, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.0, 173.91 APE9-dihe-na 67.18, 147.22 APE8-dihe-in -64.46, 149.75 APE8-rot-in 272.34 APE67-dihe-in -59.78, -28.43 -63.46, -43.86 APE12-dist-in 12.803 APE11-dist-in 11.599 APE10-dist-in 7.196 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.9 0.245 0.277 C 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2D Q13627 135 481 763.0 4H5:501 Type1 Active DFGin 7.149 14.755 BLAminus -129.65, 170.04 63.79, 89.4 -106.1, 29.98 289.31, 74.3 -69.85, -20.2 in-in in 8.582 Saltbr-in 2.925 HRD-in -65.3, -48.21 80.59, 2.84 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 173.34 APE9-dihe-na 67.44, 148.12 APE8-dihe-in -63.59, 148.85 APE8-rot-in 273.83 APE67-dihe-in -59.42, -28.15 -62.28, -44.56 APE12-dist-in 12.806 APE11-dist-in 11.569 APE10-dist-in 7.234 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 D 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4YU2 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YU2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4YU2A Q13627 134 482 763.0 4H5:502 Type1 Active DFGin 7.126 14.681 BLAminus -128.42, 169.74 66.24, 87.83 -106.58, 30.41 288.45, 76.74 -70.77, -21.27 in-in in 8.585 Saltbr-in 2.926 HRD-in -65.53, -46.44 78.54, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.92, 172.99 APE9-dihe-na 68.27, 148.59 APE8-dihe-in -64.99, 149.49 APE8-rot-in 273.44 APE67-dihe-in -60.93, -28.26 -62.53, -43.49 APE12-dist-in 12.736 APE11-dist-in 11.533 APE10-dist-in 7.136 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 A 361 349 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2B Q13627 134 481 763.0 4H5:502 Type1 Active DFGin 7.151 14.752 BLAminus -128.64, 169.94 65.22, 90.88 -106.36, 30.6 290.28, 73.66 -70.15, -21.89 in-in in 8.572 Saltbr-in 2.91 HRD-in -64.42, -46.95 79.44, 4.22 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 173.47 APE9-dihe-na 67.52, 148.21 APE8-dihe-in -62.89, 148.04 APE8-rot-in 274.18 APE67-dihe-in -57.33, -29.6 -62.96, -44.24 APE12-dist-in 12.881 APE11-dist-in 11.9 APE10-dist-in 7.282 APE9-dist-in 3.117 None PTR321 PTR321 XRAY 2.9 0.245 0.277 B 361 348 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2C Q13627 135 481 763.0 4H5:502 Type1 Active DFGin 7.149 14.733 BLAminus -129.97, 170.39 64.97, 89.04 -105.39, 29.51 288.7, 75.12 -70.27, -20.52 in-in in 8.571 Saltbr-in 2.901 HRD-in -64.55, -48.15 80.68, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.0, 173.91 APE9-dihe-na 67.18, 147.22 APE8-dihe-in -64.46, 149.75 APE8-rot-in 272.34 APE67-dihe-in -59.78, -28.43 -63.46, -43.86 APE12-dist-in 12.803 APE11-dist-in 11.599 APE10-dist-in 7.196 APE9-dist-in 3.145 None PTR321 PTR321 XRAY 2.9 0.245 0.277 C 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YU2D Q13627 135 481 763.0 4H5:501 Type1 Active DFGin 7.149 14.755 BLAminus -129.65, 170.04 63.79, 89.4 -106.1, 29.98 289.31, 74.3 -69.85, -20.2 in-in in 8.582 Saltbr-in 2.925 HRD-in -65.3, -48.21 80.59, 2.84 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 173.34 APE9-dihe-na 67.44, 148.12 APE8-dihe-in -63.59, 148.85 APE8-rot-in 273.83 APE67-dihe-in -59.42, -28.15 -62.28, -44.56 APE12-dist-in 12.806 APE11-dist-in 11.569 APE10-dist-in 7.234 APE9-dist-in 3.121 None PTR321 PTR321 XRAY 2.9 0.245 0.277 D 361 347 0 0 0 0 [[159, 479]] 1.0 4yu2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4YU2 — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name