PDB: 4YLJ — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YLJA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4YLJA Q13627 135 481 763.0 4E1:505 Type1 Active DFGin 7.171 14.69 BLAminus -120.74, 179.02 60.36, 78.67 -97.57, 26.9 291.22, 73.75 -64.98, -15.53 in-in in 8.716 Saltbr-in 2.986 HRD-in -64.06, -46.78 79.78, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.96, 172.9 APE9-dihe-na 73.38, 148.79 APE8-dihe-in -71.08, 143.3 APE8-rot-in 281.86 APE67-dihe-in -60.03, -27.35 -56.02, -46.64 APE12-dist-in 12.415 APE11-dist-in 11.382 APE10-dist-in 7.129 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.58 0.193 0.222 A 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJB Q13627 134 481 763.0 4E1:508 Type1 Active DFGin 7.17 14.829 BLAminus -121.55, 178.75 61.01, 77.19 -96.15, 26.83 289.05, 74.2 -67.89, -14.86 in-in in 8.741 Saltbr-in 2.994 HRD-in -63.71, -44.48 77.69, -2.83 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.19, 171.89 APE9-dihe-na 74.49, 148.58 APE8-dihe-in -68.34, 142.12 APE8-rot-in 282.31 APE67-dihe-in -56.89, -29.19 -56.17, -46.65 APE12-dist-in 12.631 APE11-dist-in 11.965 APE10-dist-in 7.323 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.58 0.193 0.222 B 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJC Q13627 135 481 763.0 4E1:503 Type1 Active DFGin 7.205 14.729 BLAminus -122.29, 179.51 59.93, 77.71 -95.82, 25.73 289.89, 74.73 -67.2, -13.85 in-in in 8.697 Saltbr-in 2.963 HRD-in -63.45, -46.33 78.82, -3.67 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 172.11 APE9-dihe-na 74.94, 150.31 APE8-dihe-in -71.52, 143.35 APE8-rot-in 282.23 APE67-dihe-in -59.75, -28.5 -57.04, -44.59 APE12-dist-in 12.408 APE11-dist-in 11.398 APE10-dist-in 7.171 APE9-dist-in 3.131 None PTR321 PTR321 XRAY 2.58 0.193 0.222 C 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJD Q13627 134 481 763.0 4E1:505 Type1 Active DFGin 7.199 14.803 BLAminus -121.44, 179.35 58.86, 78.49 -97.14, 26.21 290.36, 74.03 -66.11, -15.53 in-in in 8.75 Saltbr-in 2.981 HRD-in -63.57, -46.82 79.76, -3.19 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 172.88 APE9-dihe-na 73.07, 149.38 APE8-dihe-in -71.54, 142.69 APE8-rot-in 281.4 APE67-dihe-in -59.08, -29.21 -56.77, -45.97 APE12-dist-in 12.518 APE11-dist-in 11.514 APE10-dist-in 7.3 APE9-dist-in 3.134 None PTR321 PTR321 XRAY 2.58 0.193 0.222 D 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4YLJ — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4YLJA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4YLJA Q13627 135 481 763.0 4E1:505 Type1 Active DFGin 7.171 14.69 BLAminus -120.74, 179.02 60.36, 78.67 -97.57, 26.9 291.22, 73.75 -64.98, -15.53 in-in in 8.716 Saltbr-in 2.986 HRD-in -64.06, -46.78 79.78, -3.33 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.96, 172.9 APE9-dihe-na 73.38, 148.79 APE8-dihe-in -71.08, 143.3 APE8-rot-in 281.86 APE67-dihe-in -60.03, -27.35 -56.02, -46.64 APE12-dist-in 12.415 APE11-dist-in 11.382 APE10-dist-in 7.129 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.58 0.193 0.222 A 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJB Q13627 134 481 763.0 4E1:508 Type1 Active DFGin 7.17 14.829 BLAminus -121.55, 178.75 61.01, 77.19 -96.15, 26.83 289.05, 74.2 -67.89, -14.86 in-in in 8.741 Saltbr-in 2.994 HRD-in -63.71, -44.48 77.69, -2.83 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.19, 171.89 APE9-dihe-na 74.49, 148.58 APE8-dihe-in -68.34, 142.12 APE8-rot-in 282.31 APE67-dihe-in -56.89, -29.19 -56.17, -46.65 APE12-dist-in 12.631 APE11-dist-in 11.965 APE10-dist-in 7.323 APE9-dist-in 3.115 None PTR321 PTR321 XRAY 2.58 0.193 0.222 B 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJC Q13627 135 481 763.0 4E1:503 Type1 Active DFGin 7.205 14.729 BLAminus -122.29, 179.51 59.93, 77.71 -95.82, 25.73 289.89, 74.73 -67.2, -13.85 in-in in 8.697 Saltbr-in 2.963 HRD-in -63.45, -46.33 78.82, -3.67 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 172.11 APE9-dihe-na 74.94, 150.31 APE8-dihe-in -71.52, 143.35 APE8-rot-in 282.23 APE67-dihe-in -59.75, -28.5 -57.04, -44.59 APE12-dist-in 12.408 APE11-dist-in 11.398 APE10-dist-in 7.171 APE9-dist-in 3.131 None PTR321 PTR321 XRAY 2.58 0.193 0.222 C 361 347 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4YLJD Q13627 134 481 763.0 4E1:505 Type1 Active DFGin 7.199 14.803 BLAminus -121.44, 179.35 58.86, 78.49 -97.14, 26.21 290.36, 74.03 -66.11, -15.53 in-in in 8.75 Saltbr-in 2.981 HRD-in -63.57, -46.82 79.76, -3.19 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.75, 172.88 APE9-dihe-na 73.07, 149.38 APE8-dihe-in -71.54, 142.69 APE8-rot-in 281.4 APE67-dihe-in -59.08, -29.21 -56.77, -45.97 APE12-dist-in 12.518 APE11-dist-in 11.514 APE10-dist-in 7.3 APE9-dist-in 3.134 None PTR321 PTR321 XRAY 2.58 0.193 0.222 D 361 348 0 0 0 0 [[159, 479]] 1.0 4ylj Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4YLJ — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name