PDB: 4UN0 — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4UN0C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4UN0C Q9NYV4 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.2318 15.5034 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.9953 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.9363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.1272 APE11-dist-in 10.7644 APE10-dist-in 7.9437 APE9-dist-in 3.9269 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326.0 309.0 9 29 29 0 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4UN0D Q9NYV4 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.1953 15.4696 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.9588 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.8072 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.2106 APE11-dist-in 11.101 APE10-dist-in 7.9718 APE9-dist-in 3.9556 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326.0 277.0 25 29 24 5 [[727, 1020]] 1.0 4un0 CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4UN0 — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4UN0C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4UN0C Q9NYV4 719 1036 1490.0 No_ligand No_ligand Inactive DFGin 7.2318 15.5034 BLAminus -124.23, -178.57 61.68, 76.73 -100.84, 26.92 286.01, 6.79 -65.68, -44.77 in-none in 8.9953 Saltbr-none 999.0 HRD-in -69.99, -50.49 63.23, 23.44 none-in-out SNCnio in-out ActLoopNT-in 2.9363 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.84, 155.57 APE9-dihe-na 72.34, -14.08 APE8-dihe-out 67.52, 158.6 APE8-rot-out 70.66 APE67-dihe-in -58.83, -37.69 -56.4, -50.16 APE12-dist-in 13.1272 APE11-dist-in 10.7644 APE10-dist-in 7.9437 APE9-dist-in 3.9269 None TPO893 TPO893 XRAY 3.15 0.217 0.271 C 326.0 309.0 9 29 29 0 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4UN0D Q9NYV4 723 1024 1490.0 No_ligand No_ligand Inactive DFGin 7.1953 15.4696 BLAminus -123.96, -178.26 62.11, 76.94 -101.1, 26.4 286.66, 6.77 -66.07, -44.8 in-none in 8.9588 Saltbr-none 999.0 HRD-in -70.01, -50.55 63.3, 23.26 none-in-out SNCnio in-out ActLoopNT-in 2.8072 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiii APE10-dihe-na -139.6, 156.23 APE9-dihe-na 75.54, -12.58 APE8-dihe-out 66.76, 157.7 APE8-rot-out 70.35 APE67-dihe-in -58.41, -37.99 -56.68, -49.87 APE12-dist-in 13.2106 APE11-dist-in 11.101 APE10-dist-in 7.9718 APE9-dist-in 3.9556 None TPO893 TPO893 XRAY 3.15 0.217 0.271 D 326.0 277.0 25 29 24 5 [[727, 1020]] 1.0 4un0 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.2e-84 289.2 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4UN0 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name