PDB: 4NST — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4NSTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4NST — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4NSTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4NST — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name