PDB: 4MQ2 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4MQ2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4MQ2A Q13627 136 481 763.0 2C4:501 Type1 Active DFGin 6.868 14.409 BLAminus -121.27, 179.82 65.24, 80.7 -100.33, 34.12 292.19, 76.56 -77.48, -4.08 in-in in 8.662 Saltbr-in 2.601 HRD-in -69.08, -52.44 83.64, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.51, 172.47 APE9-dihe-na 67.48, 158.72 APE8-dihe-in -76.65, 148.34 APE8-rot-in 274.49 APE67-dihe-in -48.43, -32.19 -58.16, -54.33 APE12-dist-in 12.976 APE11-dist-in 11.302 APE10-dist-in 7.083 APE9-dist-in 2.96 None PTR321 PTR321 XRAY 2.8 0.193 0.258 A 361 344 2 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2B Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.053 14.829 BLAminus -112.51, 178.58 64.85, 72.08 -90.53, 21.44 285.46, 79.73 -54.32, -51.42 in-in in 8.7 Saltbr-in 2.465 HRD-in -55.52, -42.79 72.77, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 169.51 APE9-dihe-na 72.97, 142.27 APE8-dihe-in -68.49, 133.29 APE8-rot-in 303.19 APE67-dihe-in -62.35, -17.83 -46.19, -44.59 APE12-dist-in 13.951 APE11-dist-in 11.826 APE10-dist-in 7.221 APE9-dist-in 3.228 None PTR321 PTR321 XRAY 2.8 0.193 0.258 B 361 339 7 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2C Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.135 14.542 BLAminus -124.8, 176.28 61.28, 87.41 -103.36, 27.2 293.3, 79.71 -80.85, 14.66 in-in in 8.563 Saltbr-in 2.857 HRD-in -66.22, -46.45 80.74, -5.39 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 170.36 APE9-dihe-na 74.19, 145.98 APE8-dihe-in -63.45, 145.7 APE8-rot-in 275.14 APE67-dihe-in -56.78, -28.08 -53.65, -50.23 APE12-dist-in 13.336 APE11-dist-in 11.439 APE10-dist-in 7.154 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.8 0.193 0.258 C 361 340 6 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2D Q13627 135 480 763.0 2C4:501 Type1 Inactive DFGin 7.123 14.677 BLAminus -125.93, 172.67 67.54, 75.32 -95.86, 30.17 291.65, 80.25 -78.68, -5.86 in-in in 8.779 Saltbr-in 2.752 HRD-in -62.52, -51.42 84.63, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.81, 169.31 APE9-dihe-na 78.64, 158.51 APE8-dihe-in -88.72, 136.22 APE8-rot-out 152.13 APE67-dihe-in -61.7, -23.39 -43.42, -54.44 APE12-dist-in 13.722 APE11-dist-in 11.548 APE10-dist-in 7.582 APE9-dist-in 2.926 None PTR321 PTR321 XRAY 2.8 0.193 0.258 D 361 330 16 0 0 0 [[159, 479]] 1.0 4mq2 CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4MQ2 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4MQ2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4MQ2A Q13627 136 481 763.0 2C4:501 Type1 Active DFGin 6.868 14.409 BLAminus -121.27, 179.82 65.24, 80.7 -100.33, 34.12 292.19, 76.56 -77.48, -4.08 in-in in 8.662 Saltbr-in 2.601 HRD-in -69.08, -52.44 83.64, -11.94 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.51, 172.47 APE9-dihe-na 67.48, 158.72 APE8-dihe-in -76.65, 148.34 APE8-rot-in 274.49 APE67-dihe-in -48.43, -32.19 -58.16, -54.33 APE12-dist-in 12.976 APE11-dist-in 11.302 APE10-dist-in 7.083 APE9-dist-in 2.96 None PTR321 PTR321 XRAY 2.8 0.193 0.258 A 361 344 2 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2B Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.053 14.829 BLAminus -112.51, 178.58 64.85, 72.08 -90.53, 21.44 285.46, 79.73 -54.32, -51.42 in-in in 8.7 Saltbr-in 2.465 HRD-in -55.52, -42.79 72.77, 8.39 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.3, 169.51 APE9-dihe-na 72.97, 142.27 APE8-dihe-in -68.49, 133.29 APE8-rot-in 303.19 APE67-dihe-in -62.35, -17.83 -46.19, -44.59 APE12-dist-in 13.951 APE11-dist-in 11.826 APE10-dist-in 7.221 APE9-dist-in 3.228 None PTR321 PTR321 XRAY 2.8 0.193 0.258 B 361 339 7 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2C Q13627 135 480 763.0 2C4:501 Type1 Active DFGin 7.135 14.542 BLAminus -124.8, 176.28 61.28, 87.41 -103.36, 27.2 293.3, 79.71 -80.85, 14.66 in-in in 8.563 Saltbr-in 2.857 HRD-in -66.22, -46.45 80.74, -5.39 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 170.36 APE9-dihe-na 74.19, 145.98 APE8-dihe-in -63.45, 145.7 APE8-rot-in 275.14 APE67-dihe-in -56.78, -28.08 -53.65, -50.23 APE12-dist-in 13.336 APE11-dist-in 11.439 APE10-dist-in 7.154 APE9-dist-in 3.083 None PTR321 PTR321 XRAY 2.8 0.193 0.258 C 361 340 6 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4MQ2D Q13627 135 480 763.0 2C4:501 Type1 Inactive DFGin 7.123 14.677 BLAminus -125.93, 172.67 67.54, 75.32 -95.86, 30.17 291.65, 80.25 -78.68, -5.86 in-in in 8.779 Saltbr-in 2.752 HRD-in -62.52, -51.42 84.63, -0.78 in-in-out SNCiio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.81, 169.31 APE9-dihe-na 78.64, 158.51 APE8-dihe-in -88.72, 136.22 APE8-rot-out 152.13 APE67-dihe-in -61.7, -23.39 -43.42, -54.44 APE12-dist-in 13.722 APE11-dist-in 11.548 APE10-dist-in 7.582 APE9-dist-in 2.926 None PTR321 PTR321 XRAY 2.8 0.193 0.258 D 361 330 16 0 0 0 [[159, 479]] 1.0 4mq2 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4MQ2 — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name