| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 4LRMA | P00533 | 696 | 999 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 4.9304 | 14.1407 | BLAminus | -158.6, -179.81 | 59.5, 67.69 | -73.3, -10.6 | 304.95, 80.93 | -43.1, -43.98 | in-in | in | 8.5249 | Saltbr-in | 2.2504 | HRD-in | -63.46, -47.09 | 80.09, -2.56 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.4797 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -123.95, 131.0 | APE9-dihe-in | -142.36, 158.24 | APE8-dihe-in | -79.28, 92.61 | APE8-rot-na | 26.9 | APE67-dihe-in | -59.89, -28.15 | -57.58, -49.17 | APE12-dist-na | 9.4393 | APE11-dist-na | 11.0824 | APE10-dist-na | 9.6885 | APE9-dist-in | 7.1324 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | A | 334.0 | 304.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMB | P00533 | 695 | 984 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.5324 | 14.6234 | BLAminus | -142.14, -169.88 | 61.38, 66.02 | -84.65, 8.68 | 301.37, 83.75 | -51.1, -43.11 | in-in | in | 8.1741 | Saltbr-in | 2.2992 | HRD-in | -63.69, -44.58 | 74.58, 1.29 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.4201 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -94.16, 130.29 | APE9-dihe-in | -170.64, 141.47 | APE8-dihe-in | -73.49, 101.45 | APE8-rot-na | 22.26 | APE67-dihe-in | -63.2, -7.11 | -64.86, -46.08 | APE12-dist-na | 10.4399 | APE11-dist-na | 11.6213 | APE10-dist-na | 9.395 | APE9-dist-in | 6.8619 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | B | 334.0 | 290.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMC | P00533 | 694 | 983 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.5077 | 14.779 | BLAminus | -160.48, -176.43 | 59.92, 67.08 | -79.93, -1.69 | 283.78, 100.07 | -59.01, -39.57 | in-in | in | 8.9004 | Saltbr-in | 3.0715 | HRD-in | -63.5, -47.73 | 78.4, -4.25 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.2401 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -126.48, 145.03 | APE9-dihe-in | -149.11, 167.52 | APE8-dihe-in | -81.81, 92.2 | APE8-rot-na | 26.63 | APE67-dihe-in | -60.5, -24.4 | -61.07, -44.78 | APE12-dist-na | 10.4539 | APE11-dist-na | 12.2591 | APE10-dist-na | 11.0826 | APE9-dist-in | 7.237 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | C | 334.0 | 290.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMD | P00533 | 696 | 981 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.7124 | 15.2505 | BLAminus | -148.37, -162.17 | 52.48, 44.96 | -64.79, -16.2 | 243.39, 79.15 | -40.26, -53.82 | in-in | in | 8.7232 | Saltbr-in | 3.075 | HRD-in | -62.93, -45.84 | 76.67, -2.7 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.1029 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -99.87, 124.7 | APE9-dihe-in | -148.33, 129.49 | APE8-dihe-in | -84.5, 68.54 | APE8-rot-na | 31.24 | APE67-dihe-in | -68.57, -19.39 | -40.54, -45.59 | APE12-dist-na | 9.6378 | APE11-dist-na | 11.3647 | APE10-dist-na | 8.404 | APE9-dist-in | 7.2848 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | D | 334.0 | 286.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRME | P00533 | 697 | 983 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.1225 | 15.1281 | BLAminus | -149.12, 177.76 | 56.26, 51.42 | -60.22, -36.0 | 278.23, 76.29 | -54.0, 140.36 | in-in | in | 8.5484 | Saltbr-in | 2.9831 | HRD-in | -64.42, -45.57 | 82.92, -8.54 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.0805 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -59.92, 140.02 | APE9-dihe-in | -130.51, 156.61 | APE8-dihe-in | -89.68, 108.31 | APE8-rot-na | 37.48 | APE67-dihe-in | -56.1, -15.47 | -64.45, -45.1 | APE12-dist-na | 11.5293 | APE11-dist-na | 9.1163 | APE10-dist-na | 10.7777 | APE9-dist-in | 6.7823 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | E | 334.0 | 287.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | EGFR | EGFR_HUMAN | 4LRMA | P00533 | 696 | 999 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 4.9304 | 14.1407 | BLAminus | -158.6, -179.81 | 59.5, 67.69 | -73.3, -10.6 | 304.95, 80.93 | -43.1, -43.98 | in-in | in | 8.5249 | Saltbr-in | 2.2504 | HRD-in | -63.46, -47.09 | 80.09, -2.56 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.4797 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -123.95, 131.0 | APE9-dihe-in | -142.36, 158.24 | APE8-dihe-in | -79.28, 92.61 | APE8-rot-na | 26.9 | APE67-dihe-in | -59.89, -28.15 | -57.58, -49.17 | APE12-dist-na | 9.4393 | APE11-dist-na | 11.0824 | APE10-dist-na | 9.6885 | APE9-dist-in | 7.1324 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | A | 334.0 | 304.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMB | P00533 | 695 | 984 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.5324 | 14.6234 | BLAminus | -142.14, -169.88 | 61.38, 66.02 | -84.65, 8.68 | 301.37, 83.75 | -51.1, -43.11 | in-in | in | 8.1741 | Saltbr-in | 2.2992 | HRD-in | -63.69, -44.58 | 74.58, 1.29 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.4201 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -94.16, 130.29 | APE9-dihe-in | -170.64, 141.47 | APE8-dihe-in | -73.49, 101.45 | APE8-rot-na | 22.26 | APE67-dihe-in | -63.2, -7.11 | -64.86, -46.08 | APE12-dist-na | 10.4399 | APE11-dist-na | 11.6213 | APE10-dist-na | 9.395 | APE9-dist-in | 6.8619 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | B | 334.0 | 290.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMC | P00533 | 694 | 983 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.5077 | 14.779 | BLAminus | -160.48, -176.43 | 59.92, 67.08 | -79.93, -1.69 | 283.78, 100.07 | -59.01, -39.57 | in-in | in | 8.9004 | Saltbr-in | 3.0715 | HRD-in | -63.5, -47.73 | 78.4, -4.25 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.2401 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -126.48, 145.03 | APE9-dihe-in | -149.11, 167.52 | APE8-dihe-in | -81.81, 92.2 | APE8-rot-na | 26.63 | APE67-dihe-in | -60.5, -24.4 | -61.07, -44.78 | APE12-dist-na | 10.4539 | APE11-dist-na | 12.2591 | APE10-dist-na | 11.0826 | APE9-dist-in | 7.237 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | C | 334.0 | 290.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRMD | P00533 | 696 | 981 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.7124 | 15.2505 | BLAminus | -148.37, -162.17 | 52.48, 44.96 | -64.79, -16.2 | 243.39, 79.15 | -40.26, -53.82 | in-in | in | 8.7232 | Saltbr-in | 3.075 | HRD-in | -62.93, -45.84 | 76.67, -2.7 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.1029 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -99.87, 124.7 | APE9-dihe-in | -148.33, 129.49 | APE8-dihe-in | -84.5, 68.54 | APE8-rot-na | 31.24 | APE67-dihe-in | -68.57, -19.39 | -40.54, -45.59 | APE12-dist-na | 9.6378 | APE11-dist-na | 11.3647 | APE10-dist-na | 8.404 | APE9-dist-in | 7.2848 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | D | 334.0 | 286.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| TYR | EGFR | EGFR_HUMAN | 4LRME | P00533 | 697 | 983 | 1210.0 | YUN:61101 | Type1 | Active | DFGin | 5.1225 | 15.1281 | BLAminus | -149.12, 177.76 | 56.26, 51.42 | -60.22, -36.0 | 278.23, 76.29 | -54.0, 140.36 | in-in | in | 8.5484 | Saltbr-in | 2.9831 | HRD-in | -64.42, -45.57 | 82.92, -8.54 | in-in-in | SNCiii | in-in | ActLoopNT-in | 3.0805 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -59.92, 140.02 | APE9-dihe-in | -130.51, 156.61 | APE8-dihe-in | -89.68, 108.31 | APE8-rot-na | 37.48 | APE67-dihe-in | -56.1, -15.47 | -64.45, -45.1 | APE12-dist-na | 11.5293 | APE11-dist-na | 9.1163 | APE10-dist-na | 10.7777 | APE9-dist-in | 6.7823 | None | None | None | XRAY | 3.526 | 0.227 | 0.264 | E | 334.0 | 287.0 | 0 | 30 | 30 | 0 | [[712, 970]] | 1.0 | 4lrm | Homo sapiens | TYR_EGFR_HUMAN | TYR | 1.7e-85 | 292.6 | 3.0 | 259.0 | 257.0 | 854 | 855 | 856 | 858 | 860 | 745 | 762 | 766 | 834 | 836 | 835 | 837.0 | 896 | 884 | 879 | 878 | 877 | 876 | 875 | 874 | 873 | 791 | Epidermal growth factor receptor |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|