KinCore

PDB: 4GL9 — TYR JAK2_MOUSE

Total number of chains: 0

Active chains: 0

Total number of genes: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name

PDB: 4GL9 — TYR JAK2_MOUSE

Total number of chains: 4

Active chains: 1

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	4	100.0%	4GL9A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	JAK2-2	JAK2_MOUSE	4GL9A	Q62120	843	1130	1132.0	IZA:62001	Type1	Inactive	DFGin	5.758	14.535	BLAminus	-131.1, 175.47	54.64, 81.14	-92.19, 32.98	300.1, 95.95	-58.27, -44.01	in-in	in	9.035	Saltbr-in	3.36	HRD-in	-73.72, -44.47	64.56, -43.96	in-in-out	SNCiio	in-out	ActLoopNT-in	3.107	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-55.67, 134.18	APE9-dihe-in	-146.45, 151.12	APE8-dihe-in	-74.76, 79.94	APE8-rot-na	27.08	APE67-dihe-in	-82.75, -26.09	-66.14, -14.69	APE12-dist-na	11.898	APE11-dist-na	11.346	APE10-dist-na	12.126	APE9-dist-out	8.495	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	A	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9B	Q62120	843	1130	1132.0	IZA:61201	Type1	Inactive	DFGin	5.926	13.957	BLAminus	-131.65, 175.34	54.28, 82.24	-93.18, 32.79	301.63, 90.67	-58.15, -43.04	in-in	in	8.784	Saltbr-in	2.777	HRD-in	-75.15, -44.99	64.86, -43.48	in-in-out	SNCiio	in-out	ActLoopNT-in	3.173	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-55.23, 133.88	APE9-dihe-in	-145.62, 151.28	APE8-dihe-in	-74.33, 80.39	APE8-rot-na	26.93	APE67-dihe-in	-82.22, -25.66	-66.02, -15.3	APE12-dist-na	10.854	APE11-dist-na	10.546	APE10-dist-na	11.576	APE9-dist-out	8.155	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	B	297	282	6	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9C	Q62120	843	1130	1132.0	IZA:61201	Type1	Inactive	DFGin	6.067	14.339	BLAminus	-130.77, 175.48	54.57, 81.25	-92.89, 33.32	299.53, 89.15	-58.8, -44.7	in-in	in	9.076	Saltbr-in	2.996	HRD-in	-74.67, -44.19	64.59, -44.72	in-in-out	SNCiio	in-out	ActLoopNT-in	2.94	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-53.52, 135.21	APE9-dihe-in	-144.8, 151.59	APE8-dihe-in	-74.44, 79.48	APE8-rot-na	27.41	APE67-dihe-in	-84.46, -26.89	-66.72, -16.8	APE12-dist-na	11.515	APE11-dist-na	11.177	APE10-dist-na	11.856	APE9-dist-out	8.48	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	C	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9D	Q62120	843	1130	1132.0	IZA:61201	Type1	Active	DFGin	6.113	14.104	BLAminus	-130.51, 174.55	54.31, 81.77	-91.69, 33.32	299.7, 91.33	-57.81, -43.55	in-in	in	9.037	Saltbr-in	3.326	HRD-in	-75.42, -43.64	65.18, -41.08	in-in-in	SNCiii	in-in	ActLoopNT-in	3.109	ActLoopCT-in	TYR	APEdihe_iiiai	APEdist_aaai	APE10-dihe-in	-56.34, 133.7	APE9-dihe-in	-146.39, 149.67	APE8-dihe-in	-76.13, 80.18	APE8-rot-na	27.12	APE67-dihe-in	-82.31, -26.02	-65.86, -16.39	APE12-dist-na	11.461	APE11-dist-na	10.314	APE10-dist-na	10.79	APE9-dist-in	7.989	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	D	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2

PDB: 4GL9 — TYR JAK2_MOUSE

Total number of chains: 4

Active chains: 1

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	4	100.0%	4GL9A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	JAK2-2	JAK2_MOUSE	4GL9A	Q62120	843	1130	1132.0	IZA:62001	Type1	Inactive	DFGin	5.758	14.535	BLAminus	-131.1, 175.47	54.64, 81.14	-92.19, 32.98	300.1, 95.95	-58.27, -44.01	in-in	in	9.035	Saltbr-in	3.36	HRD-in	-73.72, -44.47	64.56, -43.96	in-in-out	SNCiio	in-out	ActLoopNT-in	3.107	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-55.67, 134.18	APE9-dihe-in	-146.45, 151.12	APE8-dihe-in	-74.76, 79.94	APE8-rot-na	27.08	APE67-dihe-in	-82.75, -26.09	-66.14, -14.69	APE12-dist-na	11.898	APE11-dist-na	11.346	APE10-dist-na	12.126	APE9-dist-out	8.495	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	A	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9B	Q62120	843	1130	1132.0	IZA:61201	Type1	Inactive	DFGin	5.926	13.957	BLAminus	-131.65, 175.34	54.28, 82.24	-93.18, 32.79	301.63, 90.67	-58.15, -43.04	in-in	in	8.784	Saltbr-in	2.777	HRD-in	-75.15, -44.99	64.86, -43.48	in-in-out	SNCiio	in-out	ActLoopNT-in	3.173	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-55.23, 133.88	APE9-dihe-in	-145.62, 151.28	APE8-dihe-in	-74.33, 80.39	APE8-rot-na	26.93	APE67-dihe-in	-82.22, -25.66	-66.02, -15.3	APE12-dist-na	10.854	APE11-dist-na	10.546	APE10-dist-na	11.576	APE9-dist-out	8.155	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	B	297	282	6	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9C	Q62120	843	1130	1132.0	IZA:61201	Type1	Inactive	DFGin	6.067	14.339	BLAminus	-130.77, 175.48	54.57, 81.25	-92.89, 33.32	299.53, 89.15	-58.8, -44.7	in-in	in	9.076	Saltbr-in	2.996	HRD-in	-74.67, -44.19	64.59, -44.72	in-in-out	SNCiio	in-out	ActLoopNT-in	2.94	ActLoopCT-out	TYR	APEdihe_iiiai	APEdist_aaao	APE10-dihe-in	-53.52, 135.21	APE9-dihe-in	-144.8, 151.59	APE8-dihe-in	-74.44, 79.48	APE8-rot-na	27.41	APE67-dihe-in	-84.46, -26.89	-66.72, -16.8	APE12-dist-na	11.515	APE11-dist-na	11.177	APE10-dist-na	11.856	APE9-dist-out	8.48	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	C	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2
TYR	JAK2-2	JAK2_MOUSE	4GL9D	Q62120	843	1130	1132.0	IZA:61201	Type1	Active	DFGin	6.113	14.104	BLAminus	-130.51, 174.55	54.31, 81.77	-91.69, 33.32	299.7, 91.33	-57.81, -43.55	in-in	in	9.037	Saltbr-in	3.326	HRD-in	-75.42, -43.64	65.18, -41.08	in-in-in	SNCiii	in-in	ActLoopNT-in	3.109	ActLoopCT-in	TYR	APEdihe_iiiai	APEdist_aaai	APE10-dihe-in	-56.34, 133.7	APE9-dihe-in	-146.39, 149.67	APE8-dihe-in	-76.13, 80.18	APE8-rot-na	27.12	APE67-dihe-in	-82.31, -26.02	-65.86, -16.39	APE12-dist-na	11.461	APE11-dist-na	10.314	APE10-dist-na	10.79	APE9-dist-in	7.989	None	PTR1007,PTR1008	PTR1007,PTR1008	XRAY	3.9	0.254	0.281	D	297	284	4	0	0	0	[[545, 807], [849, 1125]]	2.0	4gl9	Mus musculus	TYR_JAK2-2_MOUSE	TYR	7.3e-87	296.9	1	260	260	993	994	995	997	999	882	898	902	973	975	974	976	1036	1024	1019	1018	1017	1016	1015	1014	1013	930	Tyrosine-protein kinase JAK2